CN115305620A - High-water-absorption cotton gauze and preparation method and application thereof - Google Patents

High-water-absorption cotton gauze and preparation method and application thereof Download PDF

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Publication number
CN115305620A
CN115305620A CN202210967276.1A CN202210967276A CN115305620A CN 115305620 A CN115305620 A CN 115305620A CN 202210967276 A CN202210967276 A CN 202210967276A CN 115305620 A CN115305620 A CN 115305620A
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water
cotton gauze
hyaluronic acid
fibers
mixing
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陈鲁帆
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Jiangsu Tianzhang Medical Health New Material Co ltd
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Jiangsu Tianzhang Medical Health New Material Co ltd
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    • D—TEXTILES; PAPER
    • D03—WEAVING
    • D03D—WOVEN FABRICS; METHODS OF WEAVING; LOOMS
    • D03D15/00—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used
    • D03D15/50—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties
    • D01F1/103—Agents inhibiting growth of microorganisms
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
    • D—TEXTILES; PAPER
    • D03—WEAVING
    • D03D—WOVEN FABRICS; METHODS OF WEAVING; LOOMS
    • D03D15/00—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used
    • D03D15/20—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads
    • D03D15/208—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads cellulose-based
    • D03D15/217—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads cellulose-based natural from plants, e.g. cotton
    • D—TEXTILES; PAPER
    • D03—WEAVING
    • D03D—WOVEN FABRICS; METHODS OF WEAVING; LOOMS
    • D03D15/00—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used
    • D03D15/40—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the structure of the yarns or threads
    • D03D15/47—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the structure of the yarns or threads multicomponent, e.g. blended yarns or threads
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
    • D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
    • D06M15/03—Polysaccharides or derivatives thereof
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
    • D06M2101/02—Natural fibres, other than mineral fibres
    • D06M2101/04—Vegetal fibres
    • D06M2101/06—Vegetal fibres cellulosic
    • D—TEXTILES; PAPER
    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2401/00—Physical properties
    • D10B2401/02—Moisture-responsive characteristics
    • D10B2401/022—Moisture-responsive characteristics hydrophylic
    • D—TEXTILES; PAPER
    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2401/00—Physical properties
    • D10B2401/13—Physical properties anti-allergenic or anti-bacterial
    • D—TEXTILES; PAPER
    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2509/00—Medical; Hygiene
    • D10B2509/02—Bandages, dressings or absorbent pads
    • D10B2509/022—Wound dressings

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  • Materials For Medical Uses (AREA)

Abstract

The invention provides high-water-absorption cotton gauze and a preparation method and application thereof, wherein the preparation method comprises the following steps: adding sodium alginate and polyvinyl alcohol into water for mixing, then adding formic acid and N, N-dimethylformamide for mixing, then adding hyaluronic acid and water-soluble chitosan, and mixing to obtain a spinning stock solution; carrying out electrostatic spinning by using the spinning solution to obtain alginate fibers; blending the alginate fibers and the cotton fibers, finishing and drying to obtain blended cotton gauze; and (3) dipping the blended cotton gauze in a hyaluronic acid solution, taking out and drying to obtain the high-water-absorption cotton gauze. The high water absorption cotton gauze disclosed by the invention can reach the water absorption rate of more than 500%, has the bacteriostatic effects on staphylococcus aureus and escherichia coli before and after water absorption of more than 88%, has the anti-pilling fluffing grade of more than 4.4, is flexible in hand feeling and good in mechanical property, and is suitable for medical dressings.

Description

High-water-absorption cotton gauze and preparation method and application thereof
Technical Field
The invention belongs to the technical field of medical materials, and relates to high-water-absorption cotton gauze as well as a preparation method and application thereof.
Background
Cotton gauze is a common traditional medical dressing, and can wrap and protect wounds and promote the wounds to heal. The cotton gauze has soft texture, low price, wide source, simpler production and processing process and repeated use. The cotton fiber has the characteristics of excellent moisture absorption and dispersion performance, good heat resistance and alkali resistance and the like, and is still widely applied in the field of medical materials.
However, after contacting with water, the fibers in the common cotton gauze are only slightly swollen, the absorption capacity is limited, a moist environment cannot be provided for the wound, and the common cotton gauze has poor antibacterial performance and is easy to cause risks such as secondary infection of the wound. Some of the prior art techniques can improve the water absorption of cotton gauze, but the mechanical properties of the cotton gauze may be deteriorated, and the cotton gauze still has the defect of poor antibacterial property.
In addition, the existing cotton gauze is easy to fluff in the using process, so that the wool fibers are easily soaked in the unhealed wound leachate to influence the healing of the wound, and the wound is also easily pulled when the gauze is taken or replaced to further influence the healing of the wound.
Therefore, in the art, it is desired to develop a cotton gauze which can ensure mechanical properties while improving water absorption and antibacterial properties, and can prevent fluffing.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide high-water-absorption cotton gauze and a preparation method thereof. The high-water-absorption cotton gauze disclosed by the invention has high water absorption, good antibacterial property and good mechanical property, and can avoid the adverse effect on a wound due to fluffing.
In order to achieve the purpose, the invention adopts the following technical scheme:
on one hand, the invention provides a preparation method of high water absorption cotton gauze, which comprises the following steps:
(1) Adding sodium alginate and polyvinyl alcohol into water for mixing, then adding formic acid and N, N-dimethylformamide for mixing, then adding hyaluronic acid and water-soluble chitosan, and mixing to obtain a spinning stock solution;
(2) Performing electrostatic spinning by using the spinning solution obtained in the step (1) to obtain alginate fibers;
(3) Blending the alginate fibers obtained in the step (2) with cotton fibers, finishing and drying to obtain blended cotton gauze;
(4) And (4) dipping the blended cotton gauze obtained in the step (3) in a hyaluronic acid solution, taking out, and drying to obtain the high-water-absorption cotton gauze.
According to the invention, alginate fibers are obtained by electrostatic spinning of sodium alginate, polyvinyl alcohol, hyaluronic acid and water-soluble chitosan, and blended cotton gauze is obtained by blending alginate fibers and cotton fibers, so that the water absorption of the cotton gauze can be enhanced, the polyvinyl alcohol can ensure the smooth spinning of the alginate fibers, the hyaluronic acid and the water-soluble chitosan are added into the electrostatic spinning solution, so that the hyaluronic acid fibers, the chitosan and the alginate fibers are tightly compounded into a whole in the electrostatic spinning process, the adhesion force of the chitosan and the fibers is enhanced, the high water-absorption cotton fibers have good antibacterial property in the using process, the antibacterial property cannot be reduced due to the water absorption of the cotton fibers, the flexibility is good, the mechanical property is good, the hyaluronic acid fibers can promote the healing of wounds on one hand, and the fluffing phenomenon of the high water-absorption cotton gauze can be reduced on the other hand.
In the invention, the combination of spinning into fibers by using hyaluronic acid and soaking the obtained blended cotton gauze in the hyaluronic acid solution is utilized, so that the fluffing phenomenon of the cotton gauze can be well solved, and in addition, the water retention and moisture retention functions of the cotton gauze are further enhanced by using the hyaluronic acid.
In the invention, hyaluronic acid can well complete electrostatic spinning in a mixed solvent of water, formic acid and N, N-dimethylformamide, and an acidic environment is provided for water-soluble chitosan, so that the chitosan can play a good antibacterial role.
In the invention, the high water absorption cotton gauze has the water absorption rate of more than 500%.
Preferably, the concentration of sodium alginate in water in step (1) is 10-20% by mass, such as 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19% or 20%.
Preferably, the concentration of the polyvinyl alcohol in the water in the step (1) is 1-5% by mass, such as 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% or 5%.
Preferably, the volume ratio of the water, the formic acid and the N, N-dimethylformamide in the step (1) is (1-3): (0.5-1): (0.5-1), for example 1.
Preferably, the hyaluronic acid in step (1) is present in a concentration of 0.3-0.6%, for example 0.3%, 0.4%, 0.5% or 0.6% by mass in the mixed solvent of water, formic acid and N, N-dimethylformamide.
The mass percentage concentration of the hyaluronic acid in the mixed solvent consisting of water, formic acid and N, N-dimethylformamide is 0.3-0.6% in the invention, which can ensure that the hyaluronic acid can be smoothly spun, if the concentration is lower than 0.3%, the spinning can be finished, but the improvement of the fluffing phenomenon of the obtained cotton gauze is not obvious, and if the concentration is higher than 0.6%, the phenomenon of spinning nozzle blockage can easily occur.
Preferably, the concentration of the water-soluble chitosan in the mixed solvent of water, formic acid and N, N-dimethylformamide in step (1) is 1-5% by mass, such as 1%, 2%, 3%, 4% or 5%. In the present invention, if the amount of the water-soluble chitosan is less than 1%, the antibacterial property of the gauze is reduced, and if the amount of the water-soluble chitosan is more than 5%, the viscosity is increased, the spinneret is easily clogged, and the spinning is not easily performed.
Preferably, the water-soluble chitosan is carboxymethyl chitosan.
Preferably, the specific steps of electrostatic spinning in step (2) are as follows: the dope is charged into an injection needle tube of an electrospinning device, a needle is connected to a high voltage source, a receiving end is connected to the ground, and then the dope is injected onto a substrate by an injection device at room temperature at a feeding rate of 0.1 to 1mL/h (e.g., 0.1mL/h, 0.3mL/h, 0.5mL/h, 0.8mL/h or 1 mL/h) at a voltage of 20kV to 30kV (e.g., 20kV, 22kV, 25kV, 28kV or 30 kV) and a receiving distance of 15cm to 20cm (e.g., 15cm, 18cm or 20 cm) to carry out electrospinning.
Preferably, the weight ratio of the alginate fibers to the cotton fibers in the step (3) is 1: (2-10), for example 1.
Preferably, the mass percentage concentration of the hyaluronic acid solution in step (4) is 1-3%, for example, 1%, 1.5%, 2%, 2.5%, 3%, etc., in the present invention, the blended cotton gauze obtained in step (3) is immersed in the hyaluronic acid solution, and hyaluronic acid and chitosan fibers in the blended cotton gauze have a good attractive interaction force, so that hyaluronic acid is uniformly covered on the surface layer of the blended cotton gauze, and the fluffing phenomenon of the cotton gauze is further improved. If the concentration of hyaluronic acid is too low, the improvement of fuzzing is not significant, while if it is more than 3%, the raw material is wasted, and further improvement of fuzzing is not caused.
Preferably, the impregnation in step (4) is performed at room temperature, and the impregnation time is 20-40min, such as 20min, 25min, 30min, 35min, 40min, etc.
In the present invention, the hyaluronic acid solution is an aqueous hyaluronic acid solution. The drying in step (3) and step (4) of the present invention may be vacuum drying.
As a preferred technical scheme of the invention, the preparation method comprises the following steps:
(1) Adding sodium alginate and polyvinyl alcohol into water for mixing, then adding formic acid and N, N-dimethylformamide for mixing, then adding hyaluronic acid and water-soluble chitosan, and mixing to obtain a spinning stock solution; the mass percentage concentration of sodium alginate in water is 10-20%, the mass percentage concentration of polyvinyl alcohol in water is 1-5%, the mass percentage concentration of hyaluronic acid in a mixed solvent composed of water, formic acid and N, N-dimethylformamide is 0.3-0.6%, and the mass percentage concentration of water-soluble chitosan in a mixed solvent composed of water, formic acid and N, N-dimethylformamide is 1-5%;
(2) Adding the spinning solution obtained in the step (1) into an injection needle tube of an electrostatic spinning device, connecting a needle head with a high-voltage source, grounding a receiving end, and injecting the spinning solution to a substrate for electrostatic spinning at room temperature through an injection device at a feeding rate of 0.1-1mL/h under the conditions that the voltage is 20kV-30kV and the receiving distance is 15cm-20cm to obtain alginate fibers;
(3) Blending the alginate fibers obtained in the step (2) with the cotton fibers according to the weight ratio of 1 (2-10), finishing and drying to obtain the blended cotton gauze;
(4) And (4) soaking the blended cotton gauze obtained in the step (3) in a hyaluronic acid solution with the mass percentage concentration of 1-3% for 20-40min at room temperature, taking out, and drying to obtain the high-water-absorption cotton gauze.
In another aspect, the invention provides the high water absorption cotton gauze prepared by the preparation method.
In another aspect, the present invention provides the use of a superabsorbent cotton gauze as described above in a medical dressing.
Compared with the prior art, the invention has the following beneficial effects:
according to the invention, alginate, polyvinyl alcohol, hyaluronic acid and water-soluble chitosan are used for electrostatic spinning to obtain alginate fibers, then the alginate fibers and the cotton fibers are blended, and the high-water-absorption cotton gauze is obtained by being impregnated in a hyaluronic acid solution, so that the water absorption of the cotton gauze is greatly enhanced, and the hyaluronic acid fibers, the chitosan and the alginate fibers are tightly compounded into a whole, so that the adhesion force of the chitosan and the fibers is enhanced, so that the high-water-absorption cotton fibers have good antibacterial property in the using process, and the antibacterial property cannot be reduced due to water absorption of the cotton fibers, and in addition, the problem that the conventional common cotton gauze is easy to fluff is solved.
The high water absorption cotton gauze disclosed by the invention can reach the water absorption rate of more than 500%, has the bacteriostatic effects on staphylococcus aureus and escherichia coli before and after water absorption of more than 88%, has the anti-pilling fluffing grade of more than 4.4, is flexible in hand feeling and good in mechanical property, and is suitable for medical dressings.
Detailed Description
The technical solution of the present invention is further described below by way of specific embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
Example 1
In this embodiment, a method for preparing a high water absorbent cotton gauze is provided, which specifically includes the following steps:
(1) Adding 20g of sodium alginate and 3g of polyvinyl alcohol into 100g of water for mixing, then adding 50g of formic acid and 100g of N, N-dimethylformamide for mixing, then adding 1g of hyaluronic acid and 5g of carboxymethyl chitosan, and mixing to obtain a spinning solution;
(2) Adding the spinning solution obtained in the step (1) into an injection needle tube of an electrostatic spinning device, connecting a needle head with a high-voltage source, grounding a receiving end, and injecting the spinning solution to a substrate through an injection device at room temperature at a feeding rate of 0.5mL/h at a voltage of 25kV and a receiving distance of 20cm to perform electrostatic spinning to obtain alginate fibers;
(3) Blending the alginate fibers obtained in the step (2) with cotton fibers according to the weight ratio of 1;
(4) And (4) soaking the blended cotton gauze obtained in the step (3) in a hyaluronic acid solution with the mass percentage concentration of 2% for 30min at room temperature, taking out, and drying to obtain the high-water-absorption cotton gauze.
Example 2
In this embodiment, a method for preparing a high water absorbent cotton gauze is provided, which specifically includes the following steps:
(1) Adding 10g of sodium alginate and 5g of polyvinyl alcohol into 100g of water for mixing, then adding 100g of formic acid and 50g of N, N-dimethylformamide for mixing, then adding 1.5g of hyaluronic acid and 10g of carboxymethyl chitosan, and mixing to obtain a spinning solution;
(2) Adding the spinning solution obtained in the step (1) into an injection needle tube of an electrostatic spinning device, connecting a needle head with a high-voltage source, grounding a receiving end, and injecting the spinning solution to a substrate through an injection device at room temperature at a voltage of 30kV and a receiving distance of 20cm at a feeding rate of 0.8mL/h to perform electrostatic spinning to obtain alginate fibers;
(3) Blending the alginate fibers obtained in the step (2) with cotton fibers according to the weight ratio of 1;
(4) And (4) soaking the blended cotton gauze obtained in the step (3) in a hyaluronic acid solution with the mass percentage concentration of 1% for 40min at room temperature, taking out, and drying to obtain the high-water-absorption cotton gauze.
Example 3
In this embodiment, a method for preparing a high water absorbent cotton gauze is provided, which specifically includes the following steps:
(1) Adding 15g of sodium alginate and 5g of polyvinyl alcohol into 100g of water for mixing, then adding 40g of formic acid and 40g of N, N-dimethylformamide for mixing, then adding 0.54g of hyaluronic acid and 1.8g of carboxymethyl chitosan, and mixing to obtain a spinning solution;
(2) Adding the spinning solution obtained in the step (1) into an injection needle tube of an electrostatic spinning device, connecting a needle head with a high-voltage source, grounding a receiving end, and injecting the spinning solution to a substrate for electrostatic spinning at room temperature through an injection device at the voltage of 20kV and the receiving distance of 20cm at the feeding rate of 1mL/h to obtain alginate fibers;
(3) Blending the alginate fibers obtained in the step (2) with cotton fibers according to the weight ratio of 1;
(4) And (4) soaking the blended cotton gauze obtained in the step (3) in a hyaluronic acid solution with the mass percentage concentration of 2.5% for 20min at room temperature, taking out and drying to obtain the high-water-absorption cotton gauze.
Example 4
In this embodiment, a method for preparing a high water absorbent cotton gauze is provided, which specifically includes the following steps:
(1) Adding 10g of sodium alginate and 1g of polyvinyl alcohol into 100g of water for mixing, then adding 50g of formic acid and 50g of N, N-dimethylformamide for mixing, then adding 1.2g of hyaluronic acid and 10g of carboxymethyl chitosan, and mixing to obtain a spinning solution;
(2) Adding the spinning solution obtained in the step (1) into an injection needle tube of an electrostatic spinning device, connecting a needle head with a high-voltage source, grounding a receiving end, and injecting the spinning solution to a substrate through an injection device at room temperature at a voltage of 25kV and a receiving distance of 18cm at a feeding rate of 0.5mL/h to perform electrostatic spinning to obtain alginate fibers;
(3) Blending the alginate fibers obtained in the step (2) with cotton fibers according to the weight ratio of 1;
(4) And (4) soaking the blended cotton gauze obtained in the step (3) in a hyaluronic acid solution with the mass percentage concentration of 2% for 30min at room temperature, taking out, and drying to obtain the high-water-absorption cotton gauze.
Example 5
In this embodiment, a method for preparing a high water absorbent cotton gauze is provided, which specifically includes the following steps:
(1) Adding 15g of sodium alginate and 4g of polyvinyl alcohol into 100g of water for mixing, then adding 80g of formic acid and 100g of N, N-dimethylformamide for mixing, then adding 1.4g of hyaluronic acid and 8.4g of carboxymethyl chitosan, and mixing to obtain spinning stock solution;
(2) Adding the spinning solution obtained in the step (1) into an injection needle tube of an electrostatic spinning device, connecting a needle head with a high-voltage source, grounding a receiving end, and injecting the spinning solution to a substrate through an injection device at room temperature at a voltage of 25kV and a receiving distance of 15cm at a feeding rate of 0.5mL/h to perform electrostatic spinning to obtain alginate fibers;
(3) Blending the alginate fibers obtained in the step (2) with cotton fibers according to the weight ratio of 1;
(4) And (4) soaking the blended cotton gauze obtained in the step (3) in a hyaluronic acid solution with the mass percentage concentration of 1.5% for 25min at room temperature, taking out and drying to obtain the high-water-absorption cotton gauze.
Example 6
In this embodiment, a method for preparing a high water absorption cotton gauze is provided, which specifically includes the following steps:
(1) Adding 12g of sodium alginate and 5g of polyvinyl alcohol into 100g of water for mixing, then adding 50g of formic acid and 100g of N, N-dimethylformamide for mixing, then adding 1.5g of hyaluronic acid and 2.5g of carboxymethyl chitosan, and mixing to obtain a spinning solution;
(2) Adding the spinning solution obtained in the step (1) into an injection needle tube of an electrostatic spinning device, connecting a needle head with a high-voltage source, grounding a receiving end, and injecting the spinning solution to a substrate through an injection device at room temperature at a voltage of 25kV and a receiving distance of 20cm at a feeding rate of 0.5mL/h to perform electrostatic spinning to obtain alginate fibers;
(3) Blending the alginate fibers obtained in the step (2) with cotton fibers according to the weight ratio of 1;
(4) And (4) soaking the blended cotton gauze obtained in the step (3) in a hyaluronic acid solution with the mass percentage concentration of 3% for 30min at room temperature, taking out, and drying to obtain the high-water-absorption cotton gauze.
Comparative example 1
In this comparative example, there was provided a method for producing a cotton gauze, which differs from example 1 only in that step (1) in example 1 was replaced with:
(1) 20g of sodium alginate and 3g of polyvinyl alcohol are added into 100g of water for mixing, and then 5g of carboxymethyl chitosan is added and mixed to obtain a spinning solution.
Comparative example 2
In this comparative example, there was provided a method for producing a cotton gauze, which was different from example 1 only in that the treatment of step (4) was not conducted and a cotton gauze was directly obtained after step (3).
Comparative example 3
The only difference from example 1 is that hyaluronic acid was added in an amount of 0.25g in step (1).
Comparative example 4
The only difference from example 1 is that the hyaluronic acid solution in step (4) has a concentration of 0.5% by mass.
Comparative example 5
The difference from example 1 is only that carboxymethyl chitosan was added in an amount of 1.25g in step (1).
The gauzes from examples 1 to 6 and comparative examples 1 to 5 and a blank control (blank cotton gauze, i.e. cotton gauze obtained by blending cotton fibres) were tested for their performance by the following method:
(1) Water absorption: the moisture absorption weighing method is adopted to test the liquid absorption performance of the gauze, and the specific operation is as follows: cutting 5cm × 5cm gauze, and accurately weighing the dry weight W 0 Putting the gauze into 100mL deionized water, absorbing the water for 30min, taking out the gauze, vertically hanging the gauze in a natural and flat place for 30s, and immediately weighing the weight W of the cotton gauze 1 Water absorption of gauze Q = (W) 1 -W 0 )/W 0 *100％。
(2) And (3) detecting antibacterial and bacteriostatic properties: taking staphylococcus aureus and escherichia coli, and bacterial suspension with bacterial turbidity of 0.5mcf, uniformly coating bacteria on a flat plate by using a medical cotton swab, repeating 3 plates for each type of bacteria, sticking the prepared absorbent cotton gauze on the bacteria-containing plate by using a sterile mirror on a super clean bench, culturing in a constant temperature box for 24 hours, and then measuring the antibacterial and bacteriostatic rate around the absorbent cotton gauze.
(3) Antibacterial property after water absorption: and (3) airing the surface of the gauze subjected to the water absorption test, and repeatedly carrying out the antibacterial and bacteriostatic activity detection in the same way to investigate the antibacterial activity of the gauze after water absorption.
(4) Anti-fuzzing performance: wool fabrics were tested for fuzz pilling rating according to GB/T4802.3-1997 textile fabric pilling test pilling box method using a model YG511-4 box pilling tester manufactured by fiber instruments Inc. in Changzhou.
The test results are shown in table 1.
TABLE 1
Figure BDA0003795230900000101
Figure BDA0003795230900000111
As can be seen from the data in Table 1, the high water absorption cotton gauze disclosed by the invention can reach a water absorption rate of more than 500%, the bacteriostatic effects on staphylococcus aureus and escherichia coli before and after water absorption can reach more than 88%, and the anti-pilling fuzzing grade is more than 4.4.
In comparative example 1, hyaluronic acid was not used in electrospinning, and formic acid and N, N-dimethylformamide solvent were not added, so that the pilling resistance and fuzz level were significantly reduced, and the antibacterial property before and after water absorption was reduced, and the water absorption was also reduced.
In comparative example 2, the impregnation with the hyaluronic acid solution of step (4) was not carried out, so that only a certain amount of hyaluronic acid fibers was contained in the cotton gauze fibers, and the pilling fuzzing resistance of the gauze could be improved properly, but the level could not reach 4.4 or more. In comparative example 3, the addition amount of hyaluronic acid in step (1) was low, so that the anti-pilling fuzzing grade reached only 3.8, and in comparative example 4, the mass percentage concentration of the hyaluronic acid solution in step (4) was low, so that the anti-pilling fuzzing grade reached only 4.0.
In comparative example 5, due to the fact that the addition amount of carboxymethyl chitosan in the step (1) is low, the amount of hyaluronic acid bound to the blended fiber during the hyaluronic acid impregnation process is relatively low, the pilling fuzzing resistance grade can only reach 4.0, and the antibacterial property is reduced.
The applicant states that the present invention is illustrated by the above examples to the high water absorption cotton gauze of the present invention and its preparation method and application, but the present invention is not limited to the above examples, i.e. it does not mean that the present invention must be implemented by the above examples. It should be understood by those skilled in the art that any modifications of the present invention, equivalent substitutions of the raw materials of the product of the present invention, and the addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

Claims (10)

1. The preparation method of the high water absorption cotton gauze is characterized by comprising the following steps:
(1) Adding sodium alginate and polyvinyl alcohol into water, mixing, then adding formic acid and N, N-dimethylformamide, mixing, then adding hyaluronic acid and water-soluble chitosan, and mixing to obtain a spinning stock solution;
(2) Performing electrostatic spinning by using the spinning solution obtained in the step (1) to obtain alginate fibers;
(3) Blending the alginate fibers obtained in the step (2) with cotton fibers, finishing and drying to obtain blended cotton gauze;
(4) And (4) dipping the blended cotton gauze obtained in the step (3) in a hyaluronic acid solution, taking out, and drying to obtain the high-water-absorption cotton gauze.
2. The preparation method of claim 1, wherein the concentration of sodium alginate in water in step (1) is 10-20% by mass;
preferably, the concentration of the polyvinyl alcohol in the step (1) in water is 1-5% by mass.
3. The method according to claim 1 or 2, wherein the weight ratio of the water, formic acid and N, N-dimethylformamide in step (1) is (1-3): (0.5-1): (0.5-1);
preferably, the mass percentage concentration of the hyaluronic acid in the mixed solvent composed of water, formic acid and N, N-dimethylformamide in the step (1) is 0.3-0.6%.
4. The production method according to any one of claims 1 to 3, wherein the water-soluble chitosan of step (1) is present in a concentration of 1 to 5% by mass in the mixed solvent of water, formic acid and N, N-dimethylformamide.
5. The method according to any one of claims 1 to 4, wherein the water-soluble chitosan of step (1) is carboxymethyl chitosan.
6. The method according to any one of claims 1 to 5, wherein the specific steps of the electrospinning of step (2) are as follows: adding the spinning solution into an injection needle tube of an electrostatic spinning device, connecting a needle head with a high-voltage source, grounding a receiving end, and injecting the spinning solution onto a substrate at room temperature through an injection device at a feeding rate of 0.1-1mL/h under the conditions that the voltage is 20kV-30kV and the receiving distance is 15cm-20cm to carry out electrostatic spinning.
7. The method according to any one of claims 1 to 6, wherein the weight ratio of the alginate fibers to the cotton fibers in step (3) is 1: (2-10);
preferably, the mass percent concentration of the hyaluronic acid solution in the step (4) is 1-3%;
preferably, the impregnation in step (4) is carried out at room temperature, and the impregnation time is 20-40min.
8. The method for preparing according to any one of claims 1 to 7, comprising the steps of:
(1) Adding sodium alginate and polyvinyl alcohol into water for mixing, then adding formic acid and N, N-dimethylformamide for mixing, then adding hyaluronic acid and water-soluble chitosan, and mixing to obtain a spinning stock solution; the mass percentage concentration of sodium alginate in water is 5-10%, the mass percentage concentration of polyvinyl alcohol in water is 1-5%, the mass percentage concentration of hyaluronic acid in a mixed solvent composed of water, formic acid and N, N-dimethylformamide is 0.3-0.6%, and the mass percentage concentration of water-soluble chitosan in a mixed solvent composed of water, formic acid and N, N-dimethylformamide is 1-5%;
(2) Adding the spinning solution obtained in the step (1) into an injection needle tube of an electrostatic spinning device, connecting a needle head with a high-voltage source, grounding a receiving end, and injecting the spinning solution to a substrate for electrostatic spinning at room temperature through an injection device at a feeding rate of 0.1-1mL/h under the conditions that the voltage is 20kV-30kV and the receiving distance is 15cm-20cm to obtain alginate fibers;
(3) Blending the alginate fibers obtained in the step (2) and the cotton fibers according to the weight ratio of 1 (2-10), finishing and drying to obtain the blended cotton gauze;
(4) And (4) soaking the blended cotton gauze obtained in the step (3) in a hyaluronic acid solution with the mass percentage concentration of 1-3% for 20-40min at room temperature, taking out and drying to obtain the high-water-absorption cotton gauze.
9. High water absorbent cotton gauze prepared by the preparation method according to any one of claims 1 to 8.
10. Use of the high water absorbent cotton gauze of claim 9 in medical dressings.
CN202210967276.1A 2022-08-12 2022-08-12 High-water-absorption cotton gauze and preparation method and application thereof Pending CN115305620A (en)

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