CN115300774A - Medicament delivery device, medicament release method and medicament release capsule using same - Google Patents
Medicament delivery device, medicament release method and medicament release capsule using same Download PDFInfo
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- CN115300774A CN115300774A CN202211035872.2A CN202211035872A CN115300774A CN 115300774 A CN115300774 A CN 115300774A CN 202211035872 A CN202211035872 A CN 202211035872A CN 115300774 A CN115300774 A CN 115300774A
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- medicament
- drug
- connecting rod
- delivery
- drug delivery
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- 239000003814 drug Substances 0.000 title claims abstract description 174
- 239000002775 capsule Substances 0.000 title claims abstract description 44
- 238000000034 method Methods 0.000 title claims abstract description 18
- 229940079593 drug Drugs 0.000 claims abstract description 64
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 18
- 238000012377 drug delivery Methods 0.000 claims description 42
- 239000011248 coating agent Substances 0.000 claims description 19
- 238000000576 coating method Methods 0.000 claims description 19
- 230000000968 intestinal effect Effects 0.000 claims description 14
- 229920000954 Polyglycolide Polymers 0.000 claims description 8
- 239000004633 polyglycolic acid Substances 0.000 claims description 8
- 230000008859 change Effects 0.000 claims description 7
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 6
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 6
- 108010010803 Gelatin Proteins 0.000 claims description 5
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- 229920000159 gelatin Polymers 0.000 claims description 5
- 239000008273 gelatin Substances 0.000 claims description 5
- 235000019322 gelatine Nutrition 0.000 claims description 5
- 235000011852 gelatine desserts Nutrition 0.000 claims description 5
- 150000004676 glycans Chemical class 0.000 claims description 5
- 229920001282 polysaccharide Polymers 0.000 claims description 5
- 239000005017 polysaccharide Substances 0.000 claims description 5
- 229920001577 copolymer Polymers 0.000 claims description 4
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 230000008569 process Effects 0.000 abstract description 7
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- 230000002496 gastric effect Effects 0.000 description 4
- 230000002457 bidirectional effect Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 2
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- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
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- 238000010521 absorption reaction Methods 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
- A61M2210/1053—Stomach
Abstract
The invention discloses a medicament delivery device, which comprises a medicament delivery window, a delivery power system, a first fixed seat, a medicament delivery connecting rod, a screw rod, a nut, a guide rod and a second fixed seat, wherein the first fixed seat is used for fixing the delivery power system, and the first fixed seat and the second fixed seat are assembled and fixed together through the guide rod and are used as a fixed base of the medicament delivery device; when the delivery power system rotates, the medicament delivery connecting rod drives the screw rod to rotate, further the rotary motion is converted into axial linear reciprocating motion through the nut, the medicament delivery connecting rod is pushed to expand, and therefore the medicament which is detachably coupled to the medicament delivery connecting rod is delivered into the intestinal tract arm through the medicament delivery window. The invention also provides a drug release capsule and a drug release method. The medicine releasing capsule of the present invention can release medicine as required during the gastrointestinal tract advancing process, so as to reach the aim of accurate medicine release, avoid the advanced decomposition and potential risk of medicine in the stomach cavity and raise the treating effect.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a medicament delivery device and a medicament release capsule using the same.
Background
At present, the medicine treatment in the medical field is mainly carried out by entering a human body through oral administration and naturally absorbing through stomach and intestine, or carrying out the treatment through intravenous injection, intramuscular injection and the like, in the process of occupying the oral administration mode of the main treatment mode, a plurality of medicines are accompanied with complications such as gastric stimulation, bleeding and the like, along with the decomposition/degradation of the medicines in the stomach cavity and the reasons such as poor reaction, slow or unstable absorption of the medicines and the like, so that the method for orally taking the medicines is limited in partial scenes, and the other method for delivering the medicines through intravenous injection and intramuscular injection has the problems of pain, infection risk and the like caused by acupuncture.
Chinese patent application No. 2020104926438 discloses a drug release capsule type alimentary canal endoscope device and a drug release method, the technical scheme is that an endoscope capsule carrying a drug cabin is sent into an alimentary canal, the position and the actual condition of a focus are obtained through video information sent back by the endoscope capsule, a wireless transmitting antenna is controlled to give a drug release signal to a wireless receiving antenna in the endoscope capsule through an external transmitting control switch, a control circuit converts the signal of the wireless receiving antenna into an instruction of the rotation and the number of rotations of a micro stepping motor, a cabin door of the drug cabin is opened with a corresponding opening, the drug in the drug cabin is released to the focus part, the release time and the release opening are controlled to control the release amount, and the cabin door is closed immediately after the release is finished to avoid the situation that the endoscope capsule moves again to scratch the inner wall of the alimentary canal. The technical scheme utilizes the wireless signal to control the action of the medicine releasing mechanism, and the medicine releasing structure can not be actuated under the condition of poor signal connection, so that the aim of the invention can not be achieved.
Chinese patent application number 2019105380071 discloses a medicine release device of a capsule endoscope and the capsule endoscope, wherein the medicine release device comprises: the drug releasing device comprises a light emitting part and a drug releasing part, wherein the light emitting part is used for emitting light, and the drug releasing part is configured to release drugs stored in the drug releasing part under the irradiation effect of the light emitted by the light emitting part. The technical scheme adopts a photoinduced driving mode to carry out linkage of a medicine release structure, and the medicine release precision of optical control is to be further improved.
In view of the deficiencies of the prior art, the present invention seeks to provide a safe and reliable delivery device for delivering a therapeutic agent into the wall of the intestinal tract, a method of releasing a drug and a drug releasing capsule therefor.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a medicament delivery device, a medicament release method and a medicament release capsule using the medicament delivery device.
In a first aspect, the invention provides a medicament delivery device, which comprises a medicament delivery window, a first delivery power system, a first fixed seat, a medicament delivery connecting rod, a first lead screw, a nut, a guide rod and a second fixed seat, wherein the first fixed seat is used for fixing the delivery power system, and the first fixed seat and the second fixed seat are jointly assembled and fixed through the guide rod to serve as a fixed base of the medicament delivery device;
when the first delivery power system rotates, the medicament delivery connecting rod drives the first screw rod to rotate, further the rotary motion is converted into axial linear reciprocating motion through the nut, the medicament delivery connecting rod is pushed to expand, and therefore the medicament which is detachably coupled to the medicament delivery connecting rod is delivered into the intestinal tract arm through the medicament delivery window.
Further, the medicament delivery windows are arranged on the surface of the shell of the medicament releasing capsule, and the number of the medicament delivery windows is at least two.
Further, the drug delivery linkage is made of any one of polyglycolic acid, polylactic acid-glycolic acid copolymer, or maltose.
Further, the first delivery power system drives the threads with positive and negative bidirectional rotation arranged at the two ends of the first screw rod to start to rotate reversely 1-2s after the medicament delivery is finished, so that the first medicament delivery device retracts and is closed.
Further, the agent delivery window is covered by a degradable coating consisting of one or more of gelatin, cellulose or polysaccharide.
Further, the medicament further comprises a needle-tip-shaped head and a barb, the needle-tip-shaped head is used for penetrating the intestinal tract arm, and the barb is used for hooking the medicament on the intestinal tract wall and is conveniently separated from the medicament delivery connecting rod.
In a second aspect, the invention provides a medicament delivery device, which comprises a second delivery power system, a first base, a first connecting rod, a rivet, a second connecting rod, a second base and a second screw rod, wherein the second delivery power system is connected with the second screw rod and transmits power through the second screw rod; first base and second base are connected respectively to the both ends of second lead screw, first base and second base can be linear motion on the second lead screw respectively, first connecting rod and second connecting rod are connected respectively to first base and second base, and first connecting rod can rotate around first base, and the second connecting rod can rotate around the second base, and first connecting rod passes through rivet riveting with the second connecting rod, first connecting rod and second connecting rod swing around rivet center each other.
Furthermore, the first connecting rod, the second connecting rod and the rivet are made of any one of polyglycolic acid, polylactic acid-glycolic acid copolymer or maltose.
Further, the second delivery power system drives the threads with positive and negative bidirectional rotation arranged at the two ends of the second screw rod to start to rotate reversely 1-2s after the medicament delivery is finished, so that the medicament delivery device retracts and is closed.
In a third aspect, the present invention provides a medicament release capsule comprising a shell, a degradable coating disposed on an outer surface of the shell, a medicament, and a medicament delivery device according to any of the first to second aspects, wherein the medicament delivery device and the medicament are both disposed within the shell.
Further, the surface of the housing is provided with at least two agent delivery windows covered by a degradable coating consisting of one or more of gelatin, cellulose or polysaccharide.
In a fourth aspect, the present invention provides a drug release method, which comprises a drug release capsule, wherein after a degradable coating of the drug release capsule is degraded, the internal environment of the drug release capsule is communicated with the intestinal environment, a change in pressure or PH triggers a sensor and sends a signal to a control module, and a motor rotates and provides power to open a drug delivery device, so as to deliver and inject the drug into the intestinal wall.
The medicament delivery device and the medicament release capsule can accurately carry out medicament release operation on the affected part as required in the process of advancing in the gastrointestinal tract, achieve the aim of accurately releasing medicament, avoid the advanced decomposition and potential risk of the medicament in the gastric cavity and improve the treatment effect.
Drawings
FIG. 1: the invention discloses a whole view of a drug release capsule.
FIG. 2: the medicament delivery device of the first embodiment of the invention has a schematic structure.
FIG. 3: a schematic view of the delivery state of the first embodiment medicament delivery device.
FIG. 4: another perspective view of the first embodiment medicament delivery device.
FIG. 5 is a schematic view of: schematic view of the shape of the medicament of the delivery device of the present invention.
FIG. 6: the invention is a schematic diagram of the drug release process of the drug release capsule.
FIG. 7: the medicament delivery device according to the second embodiment of the present invention is schematically shown in an expanded state.
FIG. 8: the medicament delivery device according to the second embodiment of the present invention is schematically illustrated in a closed state.
Each serial number and corresponding name are respectively: a housing 01; a degradable coating 02; a first agent delivery device 03; an agent 04; the agent delivery window 0101; a first delivery engine 0301; a first fixed seat 0302; agent delivery link 0303; first lead screw 0304; nut 0305; guide bar 0306; a second fixing seat 0307; a pointed head 0401; barbs 0402; a second agent delivery device 05; a second delivery power system 0501, a first base 0502, a first link 0503, a rivet 0504, a second link 0505, a second base 0506, and a second lead screw 0507.
Detailed Description
In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more clearly apparent, the present invention is further described in detail below with reference to the accompanying drawings and embodiments.
Referring to fig. 1, a general view of a drug release capsule of the present invention, fig. 2, a schematic diagram of a structure of a drug delivery device of a first embodiment of the present invention, and fig. 3, a schematic diagram of a delivery state of the drug delivery device of the first embodiment of the present invention, the drug release capsule of the present invention comprises a shell 01, a degradable coating 02, a first drug delivery device 03 and a drug 04, wherein the degradable coating 02 is applied on an outer surface of the shell 01, and the drug delivery device 03 and the drug 04 are both disposed inside the shell 01.
The shell 01 is made of a biocompatible material, cannot be corroded by digestive juice, can be transparent or opaque according to needs, two ends of the shell 01 are approximately spherical, the whole drug release capsule is approximately elliptical, and is convenient for a patient to swallow and move in a digestive tract, the shell 01 is formed by splicing at least two parts, a containing cavity is formed inside the shell, the arrangement and installation of internal components are convenient, the splicing position can be flexibly designed according to needs, and the invention is not limited to the above.
The surface of the housing 01 is provided with at least two drug delivery windows 0101, the two drug delivery windows 0101 can be radially and symmetrically distributed along the housing 01, and the three or more drug delivery windows 0101 can be radially and uniformly distributed along the housing 01, which is not limited in the present invention.
The drug delivery window 0101 is sealed by the degradable coating 02 to be in a closed state when the drug release capsule does not enter the intestinal tract, after the drug release capsule enters the intestinal tract, the degradable coating 02 is in contact with body fluid in the intestinal tract to generate a degradation reaction, so that the drug delivery window 0101 is promoted to be opened, the first drug delivery device 03 in the drug release capsule is triggered, and the drug 04 is delivered into the intestinal tract through the drug delivery window 0101.
The degradable coating 02 is made of a special film-forming material for medical use, including but not limited to various biodegradable materials such as gelatin, cellulose or polysaccharide, and the degradable coating 02 is designed to be degraded only in the intestinal environment, and covers the outer surface of the corresponding drug delivery window 0101 of the shell 01, so that the drug-releasing capsule is in a sealed state. After the degradable coating 02 is degraded in the intestinal tract, the intestinal fluid enters the interior of the drug release capsule through the drug delivery window 0101 on the shell, thereby changing the triggering conditions such as the pressure or the PH value inside the drug release capsule and triggering the first drug delivery device 03 inside the drug release capsule.
Referring to fig. 4 another angle schematic view of the first embodiment medicament delivery device, the first medicament delivery device 03 further comprises a first delivery motive system 0301, a first holder 0302, a medicament delivery link 0303, a first lead screw 0304, a nut 0305, a guide bar 0306 and a second holder 0307.
The first delivery power system 0301 further includes components such as a motor, a battery, a control module, and a pressure sensor or a PH sensor, and the connection relationship of these components is well known to those skilled in the art, and the detailed description of the present invention is omitted here. After the degradable coating 02 is degraded, the internal environment of the drug release capsule is communicated with the intestinal environment, the change of pressure or PH triggers the sensor and gives a signal to the control module, the motor rotates and provides power to open the first drug delivery device 03, the drug 04 is delivered and injected into the intestinal wall, the first delivery power system 0301 is sealed in a non-degradable device with biocompatibility, and the sealing device is adaptively designed according to the requirements, which is not limited in the invention.
The first fixing seat 0302 is used for fixing a delivery power system, and the first fixing seat 0302 and the second fixing seat 0307 are assembled and fixed together through a guide rod 0306 to serve as a fixing base of the medicament delivery device 03.
When the first delivery power system 0301 receives a pressure or PH value change signal to trigger rotation, the medicament delivery connecting rod 0303 drives the first lead screw 0304 to rotate, and further converts the rotary motion into axial linear reciprocating motion through the nut 0305 to push the medicament delivery connecting rod 0303 to expand, so that the medicament 04 which is detachably coupled to the medicament delivery connecting rod 0303 is delivered into the intestinal tract arm.
When 1-10ms after the medicament delivery is finished, the first delivery power system 0301 drives the threads with positive and negative bidirectional rotation arranged at the two ends of the first lead screw 0304 to start to reversely rotate, so that the first medicament delivery device 03 performs retraction and closing after the medicament delivery is finished.
Optionally, the agent delivery link 0303 is made of a material digestible in the intestinal tract, such as but not limited to polyglycolic acid (PGA), polylactic-co-glycolic acid (PLGA), or maltose, and when the first agent delivery device 03 needs to be retracted and closed after the agent delivery is completed, the agent delivery link 0303 begins to melt after a set time (e.g., 1-2 s), so as to achieve retraction and closure of the first agent delivery device 03.
Referring to fig. 5, a schematic view of the shape of the drug agent of the delivery device of the present invention, the drug agent 04 is detachably coupled to the drug delivery link 0303, the drug agent 04 further comprises a needle-shaped head 0401 and a barb 0402, the needle-shaped head 0401 facilitates penetration into the intestinal arm, and the barb 0402 is for hooking the drug agent 04 to the intestinal wall for easy detachment from the drug delivery link 0303, and it is well known to those skilled in the art that the present invention can control the dose of the drug agent 04 coupled to the drug delivery link 0303 according to the drug dosage.
Figure 6 is a schematic view of the drug release process of the drug release capsule of the invention, the drug release capsule of the invention can accurately carry out the drug release operation at a certain position as required in the advancing process of the gastrointestinal tract, thereby achieving the purpose of accurate drug release, avoiding the advanced decomposition and potential risk of the drug in the gastric cavity and improving the treatment effect.
Referring to fig. 7, an expanded state diagram of the medicine delivery device according to the second embodiment of the present invention and fig. 8, a closed state diagram of the medicine delivery device according to the second embodiment of the present invention, the second medicine delivery device 05 includes a second power system 0501, a first base 0502, a first link 0503, a rivet 0504, a second link 0505, a second base 0506, and a second lead screw 0507.
The power system 0501 is connected with the second lead screw 0507 and transmits power through the second lead screw; the both ends of the second lead screw 0507 are connected with the first base 0502 and the second base 0506 respectively, the first base 0502 and the second base 0506 can make a straight line motion on the second lead screw 0507 respectively, the first base 0502 and the second base 0506 are connected with the first connecting rod 0503 and the second connecting rod 0505 respectively, the first connecting rod 0503 can rotate around the first base 0502, the second connecting rod 0505 can rotate around the second base 0506, the first connecting rod 0503 and the second connecting rod 0505 are riveted by the rivet 0504, the first connecting rod 0503 and the second connecting rod 0505 swing around the center of the rivet 0504.
When the medicament delivery is needed, the second power system 0501 drives the second lead screw 0507 to rotate, and the two ends of the second lead screw 0507 are provided with threads in opposite directions, so that the first base 0502 and the second base 0506 are driven to move from the two ends to the middle; when the first base 0502 and the second base 0506 move toward the middle at the same time, the horizontal distance between the first base 0502 and the second base 0506 is reduced, and the first connecting rod 0503 and the second connecting rod 0505 are forced to be unfolded from the horizontal state to a certain angle to adapt to the change of the distance, thereby realizing the unfolding of the mechanism.
When the retraction and closing are required, the second power system 0501 drives the second lead screw 0507 to rotate, the two ends of the second lead screw 0507 are provided with threads in opposite directions, so that the first base 0502 and the second base 0506 are driven to move from the middle to the two ends; when the first base 0502 and the second base 0506 are simultaneously moved to both ends, the horizontal distance between the first base 0502 and the second base 0506 is increased, and the relative angle between the first link 0503 and the second link 0505 is forced to be decreased to the horizontal to accommodate the change in distance, thereby achieving the closure of the medicament delivery device.
Alternatively, the first link 0503, the rivet 0504, and the second link 0505 are made of a material digestible to the intestine, for example, but not limited to, a material selected from polyglycolic acid (PGA), polylactic-co-glycolic acid (PLGA), and maltose, and when the second agent delivery device 05 needs to be retracted and closed after the delivery of the agent is completed, the first link 0503, the rivet 0504, and the second link 0505 begin to melt after a predetermined time (for example, 1-2 s), thereby enabling the second agent delivery device 05 to be retracted and closed.
Further, the number of the linkages and the base in the drug delivery device of the second embodiment is not limited to two, and may be configured by a plurality of groups, and those skilled in the art can make appropriate adjustments as needed without departing from the spirit and scope of the present invention.
The invention also provides a medicament delivery method, when the degradable coating 02 of the medicament-releasing capsule is degraded, the internal environment of the medicament-releasing capsule is communicated with the intestinal environment, the change of pressure or PH value triggers the sensor and gives a signal to the control module, the motor rotates and provides power to open the medicament delivery device 03, and the medicament 04 is delivered and injected into the intestinal wall.
The medicament delivery device, the medicament release method and the medicament release capsule thereof can accurately carry out medicament release operation on the affected part as required in the process of advancing in the gastrointestinal tract, thereby achieving the aim of accurately releasing the medicament, avoiding the advanced decomposition and potential risk of the medicament in the gastric cavity and improving the treatment effect.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (12)
1. The drug delivery device is characterized by comprising a drug delivery window, a first delivery power system, a first fixed seat, a drug delivery connecting rod, a first lead screw, a nut, a guide rod and a second fixed seat, wherein the first fixed seat is used for fixing the delivery power system, and the first fixed seat and the second fixed seat are jointly assembled and fixed through the guide rod to serve as fixed bases of the drug delivery device;
when the first delivery power system rotates, the medicament delivery connecting rod drives the first screw rod to rotate, further the rotary motion is converted into axial linear reciprocating motion through the nut, the medicament delivery connecting rod is pushed to expand, and therefore the medicament which is detachably coupled to the medicament delivery connecting rod is delivered into the intestinal tract arm through the medicament delivery window.
2. The drug delivery apparatus of claim 1, wherein the drug delivery windows are disposed on a surface of a housing of the drug-releasing capsule, and wherein the number of the drug delivery windows is at least two.
3. The drug delivery apparatus of claim 1, wherein the drug delivery linkage is made of any one of polyglycolic acid, polylactic acid-glycolic acid copolymer, or maltose.
4. The drug delivery device of claim 1, wherein the first delivery power system drives the threads with positive and negative bi-directional rotation disposed at both ends of the first lead screw to start to rotate in reverse after 1-2s after the drug delivery is completed, so that the first drug delivery device performs retraction and closing.
5. The drug delivery device of claim 1, wherein said drug delivery window is covered by a degradable coating comprised of one or more of gelatin, cellulose or polysaccharide.
6. The drug delivery apparatus of claim 1, wherein the drug further comprises a needle-like head for penetrating the intestinal wall and a barb for hooking the drug to the intestinal wall for facilitating disengagement from the drug delivery linkage.
7. The medicament delivery device is characterized by comprising a second delivery power system, a first base, a first connecting rod, a rivet, a second connecting rod, a second base and a second screw rod, wherein the second delivery power system is connected with the second screw rod and transmits power through the second screw rod; first base and second base are connected respectively to the both ends of second lead screw, first base and second base can be linear motion on the second lead screw respectively, first connecting rod and second connecting rod are connected respectively to first base and second base, and first connecting rod can rotate around first base, and the second connecting rod can rotate around the second base, and first connecting rod passes through rivet riveting with the second connecting rod, first connecting rod and second connecting rod swing around rivet center each other.
8. The drug delivery apparatus of claim 7, wherein the first link, the second link and the rivet are made of any one of polyglycolic acid, polylactic acid-glycolic acid copolymer or maltose.
9. The drug delivery apparatus of claim 7, wherein the second delivery power system drives the screw threads with forward and reverse rotation provided at both ends of the second screw rod to start to rotate reversely 1-2s after the drug delivery is completed, so that the drug delivery apparatus performs retraction and closure.
10. A medicament release capsule comprising a shell, a degradable coating, a medicament and a medicament delivery device according to any of claims 1 to 9, wherein the degradable coating is applied to the outer surface of the shell and the medicament delivery device and the medicament are both contained within the shell.
11. A medicament release capsule according to claim 10, wherein at least two medicament delivery windows are provided in the surface of said shell, said medicament delivery windows being covered by a degradable coating consisting of one or more of gelatin, cellulose or polysaccharide.
12. A drug release method comprises a drug release capsule and is characterized in that after a degradable coating of the drug release capsule is degraded, the internal environment of the drug release capsule is communicated with the intestinal environment, the change of pressure or PH value triggers a sensor and gives a signal to a control module, and a motor rotates and provides power to open a drug delivery device so as to deliver and inject the drug into the intestinal wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211035872.2A CN115300774B (en) | 2022-08-27 | 2022-08-27 | Medicament delivery device, medicament release method and medicament release capsule using same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211035872.2A CN115300774B (en) | 2022-08-27 | 2022-08-27 | Medicament delivery device, medicament release method and medicament release capsule using same |
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| CN115300774A true CN115300774A (en) | 2022-11-08 |
| CN115300774B CN115300774B (en) | 2024-01-30 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130165859A1 (en) * | 2010-12-23 | 2013-06-27 | Incube Labs, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US20130189353A1 (en) * | 2010-12-23 | 2013-07-25 | Rani Therapeutics, LLC. | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| CN103987422A (en) * | 2011-06-29 | 2014-08-13 | 拉尼医疗有限公司 | Device, system and methods for the oral delivery of therapeutic compounds |
| CN105705194A (en) * | 2013-09-05 | 2016-06-22 | 威里利生命科学有限责任公司 | Delivery of functionalized particles |
| CN114007638A (en) * | 2019-05-03 | 2022-02-01 | 拉尼医疗有限公司 | Coagulation factor formulations delivered into the intestinal tract using a swallowable drug delivery device |
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2022
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130165859A1 (en) * | 2010-12-23 | 2013-06-27 | Incube Labs, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US20130189353A1 (en) * | 2010-12-23 | 2013-07-25 | Rani Therapeutics, LLC. | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| CN103987422A (en) * | 2011-06-29 | 2014-08-13 | 拉尼医疗有限公司 | Device, system and methods for the oral delivery of therapeutic compounds |
| CN105705194A (en) * | 2013-09-05 | 2016-06-22 | 威里利生命科学有限责任公司 | Delivery of functionalized particles |
| CN114007638A (en) * | 2019-05-03 | 2022-02-01 | 拉尼医疗有限公司 | Coagulation factor formulations delivered into the intestinal tract using a swallowable drug delivery device |
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