CN115300634A - Liquid silica gel containing glucosamine chondroitin and preparation method and application thereof - Google Patents
Liquid silica gel containing glucosamine chondroitin and preparation method and application thereof Download PDFInfo
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- CN115300634A CN115300634A CN202211077034.1A CN202211077034A CN115300634A CN 115300634 A CN115300634 A CN 115300634A CN 202211077034 A CN202211077034 A CN 202211077034A CN 115300634 A CN115300634 A CN 115300634A
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- silica gel
- glucosamine
- liquid silica
- chondroitin
- chondroitin sulfate
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 112
- 239000000741 silica gel Substances 0.000 title claims abstract description 112
- 229910002027 silica gel Inorganic materials 0.000 title claims abstract description 112
- 239000007788 liquid Substances 0.000 title claims abstract description 101
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 title claims abstract description 98
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 title claims abstract description 98
- 229960002442 glucosamine Drugs 0.000 title claims abstract description 88
- 229920002567 Chondroitin Polymers 0.000 title claims abstract description 53
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims description 6
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims abstract description 58
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 55
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 55
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 55
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000000463 material Substances 0.000 claims abstract description 30
- 229920000592 inorganic polymer Polymers 0.000 claims abstract description 29
- 229920002545 silicone oil Polymers 0.000 claims abstract description 28
- 229920002050 silicone resin Polymers 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000004744 fabric Substances 0.000 claims abstract description 25
- VLDFMKOUUQYFGF-UHFFFAOYSA-N 4-(butoxymethyl)-2-methoxyphenol Chemical compound CCCCOCC1=CC=C(O)C(OC)=C1 VLDFMKOUUQYFGF-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims abstract description 22
- 235000003097 Artemisia absinthium Nutrition 0.000 claims abstract description 22
- 240000001851 Artemisia dracunculus Species 0.000 claims abstract description 22
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims abstract description 22
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims abstract description 22
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 22
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 22
- 239000001138 artemisia absinthium Substances 0.000 claims abstract description 22
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229940078465 vanillyl butyl ether Drugs 0.000 claims abstract description 22
- 239000007787 solid Substances 0.000 claims abstract description 21
- 239000008213 purified water Substances 0.000 claims abstract description 20
- 239000011550 stock solution Substances 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 16
- 239000012141 concentrate Substances 0.000 claims abstract description 3
- 238000003756 stirring Methods 0.000 claims description 49
- 239000000243 solution Substances 0.000 claims description 33
- 239000011521 glass Substances 0.000 claims description 28
- 229910001369 Brass Inorganic materials 0.000 claims description 21
- 239000010951 brass Substances 0.000 claims description 21
- 238000010438 heat treatment Methods 0.000 claims description 21
- 238000011049 filling Methods 0.000 claims description 7
- 238000007789 sealing Methods 0.000 claims description 7
- 238000007651 thermal printing Methods 0.000 claims description 2
- 238000012546 transfer Methods 0.000 claims description 2
- 239000004753 textile Substances 0.000 claims 1
- 229960002849 glucosamine sulfate Drugs 0.000 abstract description 10
- 230000035699 permeability Effects 0.000 abstract description 5
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 230000001502 supplementing effect Effects 0.000 abstract description 3
- 210000003205 muscle Anatomy 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 18
- 201000008482 osteoarthritis Diseases 0.000 description 7
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- 238000010023 transfer printing Methods 0.000 description 5
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- 239000011148 porous material Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 206010000060 Abdominal distension Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 102000055008 Matrilin Proteins Human genes 0.000 description 2
- 108010072582 Matrilin Proteins Proteins 0.000 description 2
- 206010028813 Nausea Diseases 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 210000001156 gastric mucosa Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000008693 nausea Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 239000002199 base oil Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000003321 cartilage cell Anatomy 0.000 description 1
- 230000003848 cartilage regeneration Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
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- 238000005536 corrosion prevention Methods 0.000 description 1
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- 235000016709 nutrition Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
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- 230000000630 rising effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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Abstract
The invention discloses liquid silica gel containing glucosamine chondroitin, which comprises the following components in parts by weight: 1000-1500g of inorganic polymer silica gel material, 150-200g of silicone resin, 200-250g of silicone oil, 0.1-0.3g of wormwood stock solution, 0.05-0.1g of safflower concentrate, 0.2-1g of glucosamine, 0.05-1g of chondroitin sulfate, 2-5g of vanillyl butyl ether, 2-5g of dimethyl sulfone, 3-7g of dimethyl sulfoxide and the balance of purified water; the invention utilizes the high permeability characteristic of dimethyl sulfoxide as a permeation guiding agent to carry glucosamine and chondroitin sulfate to directly reach the joint part through skin and muscle tissues; the method realizes high permeability of the glucosamine and the chondroitin sulfate, is stably fused with the liquid silica gel, can firmly attach the liquid silica gel to the fabric product in a solid state, is attached to the joint part for precise permeation, and provides more ways for supplementing the glucosamine and the chondroitin sulfate for consumers.
Description
Technical Field
The invention relates to the technical field of liquid silica gel, in particular to liquid silica gel containing glucosamine chondroitin and a preparation method and application thereof.
Background
Osteoarthritis is a degenerative joint disease with a significantly increased incidence rate with age, is the most common joint disease, and the disease progresses progressively and slowly, and is clinically manifested by joint pain, swelling, joint deformity and limited movement.
With the aging population, the incidence rate is on the rise, and the incidence rate of people over 75 years old is about 70-90%. Medical problems and medical costs associated with osteoarthritis have also increased dramatically in countries around the world, with consequent dramatic increases in lost social productivity and additional economic burden due to loss of function and labor.
Glucosamine and chondroitin sulfate have attracted extensive attention and use in regulating the metabolism of articular cartilage, supplementing the components necessary for the synthesis of articular cartilage, and repairing and protecting damaged articular cartilage.
Glucosamine and chondroitin sulfate are used as important components in the articular cartilage matrix, and research shows that the glucosamine supplement can restore the equilibrium state of the glucosamine content in joints and stimulate cartilage cells to synthesize proteoglycan and collagen fibers to generate the cartilage matrix. Glucosamine and chondroitin sulfate can relieve clinical symptoms of osteoarthritis patients, improve joint structures, repair damaged articular cartilage and delay the progress of osteoarthritis after long-term application.
At present, products taking glucosamine and chondroitin sulfate as main components on the market are divided into two types, one type is tablets, capsules, liquid beverages, oral liquids and the like which need to be orally taken, but because the oral glucosamine and chondroitin sulfate of part of people can cause adverse reactions of digestive systems such as nausea, abdominal distension, constipation and the like. In addition, the absorption rate of glucosamine chondroitin is not high, the glucosamine chondroitin is required to be taken in large dose, and the glucosamine chondroitin has very large stimulation to gastric mucosa after being taken for a long time and can also cause the increase of blood sugar and blood fat. The other is a paste or gel type external product which can be absorbed through pores to avoid various adverse reactions and side effects caused by long-term oral administration, but the glucosamine and the chondroitin have low permeability because the glucosamine and the chondroitin belong to macromolecular structures in chemical structures and are difficult to penetrate through the skin to reach joint parts.
Disclosure of Invention
The invention aims to provide liquid silica gel containing glucosamine chondroitin and a preparation method and application thereof, which aim to solve the problems that most of products taking glucosamine chondroitin sulfate as main components in the market at present are tablets, capsules, liquid beverages, oral liquids and the like which need to be orally taken, but adverse reactions of digestive systems such as nausea, abdominal distension, constipation and the like can be caused by oral administration of glucosamine chondroitin sulfate to a part of people. In addition, the absorption rate of glucosamine chondroitin is not high, the glucosamine chondroitin needs to be taken in large dose, and the glucosamine chondroitin has great stimulation to gastric mucosa after being taken for a long time and can also cause the problem of rising of blood sugar and blood fat.
In order to achieve the purpose, the invention provides the following technical scheme: the liquid silica gel containing glucosamine chondroitin comprises the following components in parts by weight: 1000-1500g of inorganic polymer silica gel material, 150-200g of silicone resin, 200-250g of silicone oil, 0.1-0.3g of wormwood stock solution, 0.05-0.1g of safflower concentrate, 0.2-1g of glucosamine, 0.05-1g of chondroitin sulfate, 2-5g of vanillyl butyl ether, 2-5g of dimethyl sulfone, 3-7g of dimethyl sulfoxide and the balance of purified water.
Inorganic polymer silica gel material (food-grade antiallergic base material), silicone resin (with waterproof property, sweat corrosion prevention), silicone oil (base oil, skin inflammation prevention), wormwood raw liquid (dampness eliminating and pain relieving), safflower concentrated liquid (sore and ulcer swelling and pain), glucosamine (pain relieving of osteoarthritis, and osteoarthritis course prevention development), chondroitin sulfate (cartilage regeneration promotion), vanillyl butyl ether (thermal inductance agent, pore expansion stimulation, slow separation of glucosamine and chondroitin sulfate, absorption facilitation), dimethyl sulfoxide (penetrant), and dimethyl sulfone (nutritional agent).
The liquid silica gel comprises the following components in parts by weight: 1000g of inorganic polymer silica gel material, 150g of silicone resin, 200g of silicone oil, 0.3g of wormwood raw liquid, 0.1g of safflower concentrated solution, 1g of glucosamine, 1g of chondroitin sulfate, 2g of vanillyl butyl ether, 5g of dimethyl sulfone, 7g of dimethyl sulfoxide and 100g of purified water.
The liquid silica gel comprises the following components in parts by weight: 1000g of inorganic polymer silica gel material, 150g of silicone resin, 200g of silicone oil, 0.2g of wormwood stock solution, 0.1g of safflower concentrated solution, 0.5g of glucosamine, 0.5g of chondroitin sulfate, 2g of vanillyl butyl ether, 4g of dimethyl sulfone, 6g of dimethyl sulfoxide and 100g of purified water.
The liquid silica gel comprises the following components in parts by weight: 1000g of inorganic polymer silica gel material, 150g of silicone resin, 200g of silicone oil, 0.1g of wormwood stock solution, 0.05g of safflower concentrated solution, 0.2g of glucosamine, 0.05g of chondroitin sulfate, 2g of vanillyl butyl ether, 2g of dimethyl sulfone, 3g of dimethyl sulfoxide and 100g of purified water.
The liquid silica gel comprises the following components in parts by weight: 1000g of inorganic polymer silica gel material, 150g of silicone resin, 200g of silicone oil, 0.2g of wormwood stock solution, 0.1g of safflower concentrated solution, 0.3g of glucosamine, 0.3g of chondroitin sulfate, 2g of vanillyl butyl ether, 3g of dimethyl sulfone, 4g of dimethyl sulfoxide and 100g of purified water.
The liquid silica gel comprises the following components in parts by weight: 1000g of inorganic polymer silica gel material, 150g of silicone resin, 200g of silicone oil, 0.3g of wormwood stock solution, 0.1g of safflower concentrated solution, 0.5g of glucosamine, 0.5g of chondroitin sulfate, 2g of vanillyl butyl ether, 4g of dimethyl sulfone, 5g of dimethyl sulfoxide and 100g of purified water.
A preparation method of liquid silica gel containing glucosamine chondroitin comprises the following steps:
step one, dissolving glucosamine, chondroitin sulfate and dimethyl sulfone by using normal-temperature purified water until the glucosamine, the chondroitin sulfate and the dimethyl sulfone are completely dissolved, adding the wormwood stock solution, the safflower concentrated solution and dimethyl sulfoxide, and uniformly stirring;
step two, filling the solution obtained in the step one into a glass bottle, and sealing the glass bottle for later use, wherein the glass bottle is washed clean by water at the temperature of 70-80 ℃ in advance;
putting inorganic polymer silica gel material, silicone resin and silicone oil into a crucible, heating to 280-300 ℃ until the inorganic polymer silica gel material, the silicone resin and the silicone oil are completely melted to be in a liquid semitransparent state, and then placing the crucible on a dryer to be cooled to 60 ℃ to obtain liquid silica gel;
step four, pouring the liquid silica gel obtained in the step three into a stirring barrel, heating the stirring barrel to keep the temperature of the stirring barrel at 60 ℃, pouring the solution in the glass bottle in the step two into the stirring barrel, finally pouring the vanillyl butyl ether into the stirring barrel, and uniformly stirring to obtain the liquid silica gel containing glucosamine chondroitin.
The application of the liquid silica gel containing glucosamine chondroitin comprises the following specific steps: and (3) attaching the liquid silica gel containing glucosamine chondroitin to the fabric product in a solid form by adopting a solid thermal printing technology.
The method for attaching the liquid silica gel containing glucosamine chondroitin to the fabric product in a solid form comprises the following steps:
the method comprises the following steps: uniformly placing the obtained liquid silica gel containing glucosamine chondroitin in a customized brass mould;
step two: placing a brass die on the fabric article;
step three: and (3) heating and pressurizing the brass mould by using a thermal transfer printer, and controlling the temperature, the pressure and the time to make the liquid silica gel containing glucosamine chondroitin be attached to the fabric product in a solid state.
Compared with the prior art, the invention has the beneficial effects that:
the invention utilizes the high permeability characteristic of dimethyl sulfoxide as a permeation guiding agent to carry glucosamine and chondroitin sulfate to directly reach the joint part through skin and muscle tissues; the glucosamine and chondroitin sulfate are high in permeability and stably fused with the liquid silica gel, the liquid silica gel can be firmly attached to a fabric product in a solid form and attached to joint parts for accurate permeation, and more ways for supplementing the glucosamine and chondroitin sulfate are provided for consumers.
Detailed Description
The technical solution of the present invention is further described in detail with reference to the following embodiments, but the present invention is not limited thereto, and any limited number of modifications made by anyone within the scope of the present invention are still within the scope of the present invention. It should be noted that the raw materials used in the technical scheme provided by the present invention are all purchased from the market by conventional means except for special instructions.
Example 1
Preparing liquid silica gel containing glucosamine chondroitin and chondroitin sulfate, comprising the following steps:
step one, dissolving 1g of glucosamine, 1g of chondroitin sulfate and 5g of dimethyl sulfone by using 100g of normal-temperature purified water until the glucosamine, the chondroitin sulfate and the dimethyl sulfone are completely dissolved, and then adding 0.3g of wormwood stock solution, 0.1g of safflower concentrated solution and 7g of dimethyl sulfoxide and uniformly stirring;
step two, filling the solution obtained in the step one into a glass bottle, and sealing the glass bottle for later use, wherein the glass bottle is washed clean by water at 70-80 ℃;
putting 1000g of inorganic polymer silica gel material, 150g of silicone resin and 200g of silicone oil into a crucible, heating to 300 ℃ until the inorganic polymer silica gel material, the silicone resin and the silicone oil are completely melted to be in a liquid semitransparent state, and then putting the crucible on a dryer to cool to 60 ℃;
and step four, pouring the liquid silica gel obtained in the step three into a stirring barrel, heating the stirring barrel to keep the temperature of the stirring barrel at 60 ℃, pouring the solution in the glass bottle in the step two into the stirring barrel, finally pouring 2g of vanillyl butyl ether into the stirring barrel, and uniformly stirring to obtain the liquid silica gel containing glucosamine chondroitin.
(II) the method for attaching the liquid silica gel containing glucosamine chondroitin to the fabric product in a solid form comprises the following steps:
the method comprises the following steps: uniformly placing the obtained liquid silica gel containing glucosamine chondroitin and chondroitin sulfate in a customized brass mould, wherein the thickness of the liquid silica gel is about 1 mm;
step two: placing a brass die on the fabric article;
step three: and heating and pressurizing the brass mould by using a thermal transfer printing machine at the temperature of 180 ℃ and under the pressure of 5000hpa for 30s, so that the liquid silica gel can be firmly attached to the fabric product in a solid form.
Example 2
Preparing liquid silica gel containing glucosamine chondroitin and chondroitin sulfate, comprising the following steps:
step one, dissolving 0.5g of glucosamine, 0.5g of chondroitin sulfate and 4g of dimethyl sulfone by using 100g of normal-temperature purified water until the glucosamine, the chondroitin sulfate and the dimethyl sulfone are completely dissolved, and then adding 0.2g of wormwood stock solution, 0.1g of safflower concentrated solution and 6g of dimethyl sulfoxide and uniformly stirring;
step two, filling the solution obtained in the step one into a glass bottle, and sealing the glass bottle for later use, wherein the glass bottle is washed clean by water at the temperature of 70-80 ℃ in advance;
putting 1000g of inorganic polymer silica gel material, 150g of silicone resin and 200g of silicone oil into a crucible, heating to 300 ℃ until the inorganic polymer silica gel material, the silicone resin and the silicone oil are completely melted to be in a liquid semitransparent state, and then putting the crucible on a dryer to cool to 60 ℃;
and step four, pouring the liquid silica gel obtained in the step three into a stirring barrel, heating the stirring barrel to keep the temperature of the stirring barrel at 60 ℃, pouring the solution in the glass bottle in the step two into the stirring barrel, finally pouring 2g of vanillyl butyl ether into the stirring barrel, and uniformly stirring to obtain the liquid silica gel containing glucosamine chondroitin.
(II) the method for attaching the liquid silica gel containing glucosamine chondroitin to the fabric product in a solid form comprises the following steps:
the method comprises the following steps: uniformly placing the obtained liquid silica gel containing glucosamine chondroitin and chondroitin sulfate in a customized brass mould, wherein the thickness of the liquid silica gel is about 1 mm;
step two: placing a brass die on the fabric article;
step three: and heating and pressurizing the brass mould by using a thermal transfer printing machine at the temperature of 150 ℃, under the pressure of 4500hpa for 30s, so that the liquid silica gel can be firmly attached to the fabric product in a solid form.
Example 3
Preparing liquid silica gel containing glucosamine chondroitin and chondroitin sulfate, comprising the following steps:
step one, dissolving 0.2g of glucosamine, 0.05g of chondroitin sulfate and 2g of dimethyl sulfone by using 100g of normal-temperature purified water until the glucosamine, the chondroitin sulfate and the dimethyl sulfone are completely dissolved, and then adding 0.1g of wormwood stock solution, 0.05g of safflower concentrated solution and 3g of dimethyl sulfoxide and uniformly stirring;
step two, filling the solution obtained in the step one into a glass bottle, and sealing the glass bottle for later use, wherein the glass bottle is washed clean by water at the temperature of 70-80 ℃ in advance;
putting 1000g of inorganic polymer silica gel material, 150g of silicone resin and 200g of silicone oil into a crucible, heating to 300 ℃ until the inorganic polymer silica gel material, the silicone resin and the silicone oil are completely melted to be in a liquid semitransparent state, and then putting the crucible on a dryer to cool to 60 ℃;
and step four, pouring the liquid silica gel obtained in the step three into a stirring barrel, heating the stirring barrel to keep the temperature of the stirring barrel at 60 ℃, pouring the solution in the glass bottle in the step two into the stirring barrel, finally pouring 2g of vanillyl butyl ether into the stirring barrel, and uniformly stirring to obtain the liquid silica gel containing glucosamine chondroitin.
(II) the method for attaching the liquid silica gel containing glucosamine chondroitin to the fabric product in a solid form comprises the following steps:
the method comprises the following steps: uniformly placing the obtained liquid silica gel containing glucosamine chondroitin and chondroitin sulfate in a customized brass mould, wherein the thickness of the liquid silica gel is about 1 mm;
step two: placing a brass die on the fabric article;
step three: and heating and pressurizing the brass mould by using a thermal transfer printing machine at the temperature of 150 ℃, under the pressure of 4040hpa for 30s, so that the liquid silica gel can be firmly attached to the fabric product in a solid form.
Example 4
Preparing liquid silica gel containing glucosamine chondroitin and chondroitin sulfate, comprising the following steps:
step one, dissolving 0.3g of glucosamine, 0.3g of chondroitin sulfate and 3g of dimethyl sulfone by using 100g of normal-temperature purified water until the glucosamine, the chondroitin sulfate and the dimethyl sulfone are completely dissolved, and then adding 0.2g of wormwood stock solution, 0.1g of safflower concentrated solution and 4g of dimethyl sulfoxide and uniformly stirring;
step two, filling the solution obtained in the step one into a glass bottle, and sealing the glass bottle for later use, wherein the glass bottle is washed clean by water at the temperature of 70-80 ℃ in advance;
putting 1000g of inorganic polymer silica gel material, 150g of silicone resin and 200g of silicone oil into a crucible, heating to 280 ℃ until the inorganic polymer silica gel material is completely melted and is in a liquid semitransparent state, and then placing the crucible on a dryer to be cooled to 60 ℃;
and step four, pouring the liquid silica gel obtained in the step three into a stirring barrel, heating the stirring barrel to keep the temperature of the stirring barrel at 60 ℃, pouring the solution in the glass bottle in the step two into the stirring barrel, finally pouring 2g of vanillyl butyl ether into the stirring barrel, and uniformly stirring to obtain the liquid silica gel containing glucosamine chondroitin.
(II) the method for attaching the liquid silica gel containing glucosamine chondroitin to the fabric product in a solid form comprises the following steps:
the method comprises the following steps: uniformly placing the obtained liquid silica gel containing glucosamine chondroitin and chondroitin sulfate in a customized brass mould, wherein the thickness of the liquid silica gel is about 1 mm;
step two: placing a brass die on the fabric article;
step three: and heating and pressurizing the brass mould by using a thermal transfer printing machine at the temperature of 160 ℃, under the pressure of 4040hpa for 35s, so that the liquid silica gel can be firmly attached to the fabric product in a solid form.
Example 5
Preparing liquid silica gel containing glucosamine chondroitin and chondroitin sulfate, comprising the following steps:
step one, dissolving 0.5g of glucosamine, 0.5g of chondroitin sulfate and 4g of dimethyl sulfone by using 100g of normal-temperature purified water until the glucosamine, the chondroitin sulfate and the dimethyl sulfone are completely dissolved, and then adding 0.3g of wormwood stock solution, 0.1g of safflower concentrated solution and 5g of dimethyl sulfoxide and uniformly stirring;
step two, filling the solution obtained in the step one into a glass bottle, and sealing the glass bottle for later use, wherein the glass bottle is washed clean by water at the temperature of 70-80 ℃ in advance;
putting 1000g of inorganic polymer silica gel material, 150g of silicone resin and 200g of silicone oil into a crucible, heating to 290 ℃ until the inorganic polymer silica gel material, the silicone resin and the silicone oil are completely melted to be in a liquid semitransparent state, and then placing the crucible on a dryer to be cooled to 60 ℃;
and step four, pouring the liquid silica gel obtained in the step three into a stirring barrel, heating the stirring barrel to keep the temperature of the stirring barrel at 60 ℃, pouring the solution in the glass bottle in the step two into the stirring barrel, finally pouring 2g of vanillyl butyl ether into the stirring barrel, and uniformly stirring to obtain the liquid silica gel containing glucosamine chondroitin.
(II) the method for attaching the liquid silica gel containing glucosamine chondroitin to the fabric product in a solid form comprises the following steps:
the method comprises the following steps: uniformly placing the obtained liquid silica gel containing glucosamine chondroitin and chondroitin sulfate in a customized brass mould, wherein the thickness of the liquid silica gel is about 1 mm;
step two: placing a brass die on the fabric article;
step three: and heating and pressurizing the brass mould by using a thermal transfer printing machine at the temperature of 170 ℃, under the pressure of 5050hpa for 25s, so that the liquid silica gel can be firmly attached to the fabric product in a solid form.
The results of the experiment are shown in table 1 below:
TABLE 1
| Item | Example one | Example two | EXAMPLE III | Example four | EXAMPLE five |
| Precipitation of | Brown precipitate | Brown precipitate | Is free of | Is composed of | Is free of |
| Transparency | Semi-transparent | Semi-transparent | Semi-transparent | Semi-transparent | Semi-transparent |
| Local skin temperature | 36.8℃ | 38℃ | 39.3℃ | 39.8℃ | 40.2℃ |
| Adhesion force | Semi-shedding | Semi-shedding | Without falling off | Without falling off | Without falling off |
In summary, the following steps:
1. 0.2-1g of glucosamine, 0.05-1g of chondroitin sulfate, 0.1-0.3g of wormwood raw liquid, 0.05-0.1g of safflower concentrated solution, 2-5g of dimethyl sulfone and 3-7g of dimethyl sulfoxide, and the dissolving effect is best and no precipitate is generated in 100g of water.
2. The inorganic polymer silica gel material, the silicone resin and the silicone oil have the best melting effect at the temperature of 280-300 ℃ and can be in a liquid semitransparent state.
3. The addition of the vanillyl butyl ether can enable the local skin to reach about 40 ℃, and better promote pore expansion.
4. The temperature is 150-170 ℃, the pressure is 4040-5050hpa, and the time is 25-30s, so that the liquid silica gel can be firmly attached to the fabric product in a solid form.
All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
Claims (9)
1. A liquid silica gel containing glucosamine chondroitin, which is characterized in that: the liquid silica gel comprises the following components in parts by weight: 1000-1500g of inorganic polymer silica gel material, 150-200g of silicone resin, 200-250g of silicone oil, 0.1-0.3g of wormwood stock solution, 0.05-0.1g of safflower concentrate, 0.2-1g of glucosamine, 0.05-1g of chondroitin sulfate, 2-5g of vanillyl butyl ether, 2-5g of dimethyl sulfone, 3-7g of dimethyl sulfoxide and the balance of purified water.
2. The liquid silica gel containing glucosamine chondroitin according to claim 1, wherein the liquid silica gel comprises the following components in parts by weight: 1000g of inorganic polymer silica gel material, 150g of silicone resin, 200g of silicone oil, 0.3g of wormwood raw liquid, 0.1g of safflower concentrated solution, 1g of glucosamine, 1g of chondroitin sulfate, 2g of vanillyl butyl ether, 5g of dimethyl sulfone, 7g of dimethyl sulfoxide and 100g of purified water.
3. The liquid silica gel containing glucosamine chondroitin according to claim 1, wherein the liquid silica gel comprises the following components in parts by weight: 1000g of inorganic polymer silica gel material, 150g of silicone resin, 200g of silicone oil, 0.2g of wormwood stock solution, 0.1g of safflower concentrated solution, 0.5g of glucosamine, 0.5g of chondroitin sulfate, 2g of vanillyl butyl ether, 4g of dimethyl sulfone, 6g of dimethyl sulfoxide and 100g of purified water.
4. The liquid silica gel containing glucosamine chondroitin according to claim 1, wherein the liquid silica gel comprises the following components in parts by weight: 1000g of inorganic polymer silica gel material, 150g of silicone resin, 200g of silicone oil, 0.1g of wormwood stock solution, 0.05g of safflower concentrated solution, 0.2g of glucosamine, 0.05g of chondroitin sulfate, 2g of vanillyl butyl ether, 2g of dimethyl sulfone, 3g of dimethyl sulfoxide and 100g of purified water.
5. The liquid silica gel containing glucosamine chondroitin according to claim 1, wherein the liquid silica gel comprises the following components in parts by weight: 1000g of inorganic polymer silica gel material, 150g of silicone resin, 200g of silicone oil, 0.2g of wormwood stock solution, 0.1g of safflower concentrated solution, 0.3g of glucosamine, 0.3g of chondroitin sulfate, 2g of vanillyl butyl ether, 3g of dimethyl sulfone, 4g of dimethyl sulfoxide and 100g of purified water.
6. The liquid silica gel containing glucosamine chondroitin according to claim 1, wherein the liquid silica gel comprises the following components in parts by weight: 1000g of inorganic polymer silica gel material, 150g of silicone resin, 200g of silicone oil, 0.3g of wormwood raw liquid, 0.1g of safflower concentrated solution, 0.5g of glucosamine, 0.5g of chondroitin sulfate, 2g of vanillyl butyl ether, 4g of dimethyl sulfone, 5g of dimethyl sulfoxide and 100g of purified water.
7. A preparation method of liquid silica gel containing glucosamine chondroitin is characterized by comprising the following steps:
step one, dissolving glucosamine, chondroitin sulfate and dimethyl sulfone by using normal-temperature purified water until the glucosamine, the chondroitin sulfate and the dimethyl sulfone are completely dissolved, adding the wormwood stock solution, the safflower concentrated solution and dimethyl sulfoxide, and uniformly stirring;
step two, filling the solution obtained in the step one into a glass bottle, and sealing the glass bottle for later use, wherein the glass bottle is washed clean by water at the temperature of 70-80 ℃ in advance;
putting inorganic polymer silica gel material, silicone resin and silicone oil into a crucible, heating to 280-300 ℃ until the inorganic polymer silica gel material, the silicone resin and the silicone oil are completely melted to be in a liquid semitransparent state, and then placing the crucible on a dryer to be cooled to 60 ℃ to obtain liquid silica gel;
and step four, pouring the liquid silica gel obtained in the step three into a stirring barrel, heating the stirring barrel to keep the temperature of the stirring barrel at 60 ℃, pouring the solution in the glass bottle in the step two into the stirring barrel, finally pouring the vanillyl butyl ether into the stirring barrel, and uniformly stirring to obtain the liquid silica gel containing glucosamine chondroitin.
8. Use of a liquid silica gel comprising chondroitin sulfate according to any of claims 1-7, wherein the liquid silica gel comprising chondroitin sulfate is attached to a textile article in a solid form by a solid state thermal printing technique.
9. The use of liquid silica gel containing glucosamine chondroitin according to claim 8, wherein the method for attaching the liquid silica gel containing glucosamine chondroitin to a fabric article in a solid form comprises the following steps:
the method comprises the following steps: uniformly placing the obtained liquid silica gel containing glucosamine chondroitin in a customized brass mould;
step two: placing a brass die on the fabric article;
step three: and (3) heating and pressurizing the brass mould by using a thermal transfer printer, and controlling the temperature, the pressure and the time to make the liquid silica gel containing glucosamine chondroitin be attached to the fabric product in a solid state.
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