CN115281620A

CN115281620A - Imaging probe

Info

Publication number: CN115281620A
Application number: CN202210964732.7A
Authority: CN
Inventors: 杨西斌
Original assignee: Suzhou Kexun Micro Optoelectronic Technology Co ltd
Current assignee: Suzhou Kexun Micro Optoelectronic Technology Co ltd
Priority date: 2022-08-11
Filing date: 2022-08-11
Publication date: 2022-11-04

Abstract

The invention discloses an imaging probe, which belongs to the field of endoscope optical systems and comprises an optical fiber, a fixed sleeve, a reflector, a sleeve shell, an ultrasonic transducer, a target surface to be detected and a glass window which are sequentially arranged from the system side, wherein exciting light transmitted by the optical fiber is reflected by the reflector and focused on the target surface to be detected, fluorescence emitted by the target surface to be detected returns in a primary path and is received by the optical system to form fluorescence imaging, and meanwhile, the focused light can cause the target surface to be detected to generate thermal expansion and generate ultrasonic beams which are received by the ultrasonic transducer, so that ultrasonic signals are obtained, namely, the light-excited ultrasonic imaging is formed. Compared with the prior art, the invention realizes the simultaneous imaging of targeted fluorescence imaging and ultrasound by the same probe and can obtain more disease information.

Description

Imaging probe

Technical Field

The invention belongs to the field of endoscope optical systems, and particularly relates to a bimodal in-vivo imaging probe applied to medical treatment.

Background

The incidence rate and the death rate of the digestive tract tumor in China are high, early discovery and early treatment are the core requirements of the prevention and the treatment of the digestive tract tumor, and endoscopy and biopsy cases are the main means for diagnosing the digestive tract early cancer at present. The clinical application of the in vivo peeping imaging technology improves the detection rate of the early cancer of the digestive tract, and becomes a main mode for diagnosing the early cancer and precancerous lesion of the digestive tract.

However, the current endoscopic imaging direction test is limited by an imaging probe, cannot obtain high-specificity imaging diagnosis, further improves the specificity and targeting property of endoscopic imaging, establishes direct connection between endoscopic diagnosis and pathological diagnosis, and is the current urgent clinical requirement and development direction of endoscopic imaging equipment.

Disclosure of Invention

The invention aims to: the bimodal in-vivo imaging probe applied to medical treatment can simultaneously realize fluorescence targeted imaging and photoacoustic imaging.

In order to achieve the purpose, the invention adopts the following technical scheme: an imaging probe comprises an optical fiber, a fixed sleeve, a reflector, a sleeve shell, an ultrasonic transducer, a target surface to be detected and a glass window, wherein exciting light transmitted by the optical fiber is reflected by the reflector and focused on the target surface to be detected, a fluorescence primary path emitted by the target surface to be detected returns and is received by an optical system to form fluorescence imaging, and meanwhile, the focused light can cause the target surface to be detected to generate thermal expansion to generate an ultrasonic beam which is received by the ultrasonic transducer, so that an ultrasonic signal is obtained, namely, the light-excited ultrasonic imaging is formed.

As a further description of the above technical solution:

the optical fiber is a single mode optical fiber.

As a further description of the above technical solution:

the exciting light transmitted by the optical fiber is pulse light, and the pulse width is 10-100ns.

As a further description of the above technical solution:

the sleeve shell is made of metal.

As a further description of the above technical solution:

the glass window is made of quartz.

In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:

1. in the invention, an optical fiber, a fixed sleeve, a reflector, a sleeve shell, an ultrasonic transducer, a target surface to be detected and a glass window are sequentially arranged from the system side, wherein exciting light transmitted by the optical fiber is reflected and reflected by the reflector and is focused on the target surface to be detected, a fluorescence primary path emitted by the target surface to be detected returns and is received by the optical system to form fluorescence imaging, and meanwhile, the focused light can cause the target surface to be detected to generate thermal expansion to generate ultrasonic beams which are received by the ultrasonic transducer, so that ultrasonic signals are obtained, namely, light-excited ultrasonic imaging is formed. Compared with the prior art, the invention realizes the simultaneous imaging of targeted fluorescence imaging and ultrasound by the same probe and can obtain more disease information.

2. In the invention, a medical bimodal in-vivo imaging probe is designed, which can simultaneously realize fluorescence targeted imaging and photoacoustic imaging, and simultaneously solve the problems of biopsy limitation, tumor boundary judgment and focus deep information three-dimensional imaging by one-time examination.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

Fig. 1 is a schematic structural diagram of an imaging probe.

Illustration of the drawings:

1. an optical fiber; 2. a fixed sleeve; 3. a mirror; 4. a sleeve housing; 5. an ultrasonic transducer; 6. a target surface to be detected; 7. focusing the light; 8. an ultrasonic beam; 9. a glass window.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example one

Referring to the attached drawing 1, the present invention provides a technical solution, an imaging probe, including an optical fiber 1, a fixing sleeve 2, a reflector 3, a sleeve housing 4, an ultrasonic transducer 5, a target surface 6 to be measured, and a glass window 9, wherein excitation light transmitted by the optical fiber 1 is reflected by the reflector 3 and focused on the target surface 6 to be measured, a fluorescence path emitted by the target surface 6 to be measured returns and is received by an optical system to form fluorescence imaging, and meanwhile, the focused light 7 causes thermal expansion of the target surface 6 to be measured, so as to generate an ultrasonic beam 8, which is received by the ultrasonic transducer 5, thereby obtaining an ultrasonic signal, i.e., forming light-excited ultrasonic imaging.

The optical fiber 1 is a single mode optical fiber.

The exciting light transmitted by the optical fiber 1 is pulse light, and the pulse width is 10-100ns.

The sleeve shell 4 is made of metal.

The glass window 9 is made of quartz.

The working principle is as follows: the system comprises an optical fiber, a fixed sleeve, a reflector, a sleeve shell, an ultrasonic transducer, a target surface to be detected and a glass window which are sequentially arranged from the system side, wherein exciting light transmitted by the optical fiber is reflected and reflected by the reflector and is focused on the target surface to be detected, a fluorescence original path emitted by the target surface to be detected returns and is received by the optical system to form fluorescence imaging, and meanwhile, the focused light can cause thermal expansion of the target surface to be detected to generate ultrasonic beams which are received by the ultrasonic transducer, so that ultrasonic signals are obtained, and the light-excited ultrasonic imaging is formed. Compared with the prior art, the invention realizes the simultaneous imaging of targeted fluorescence imaging and ultrasound by the same probe and can obtain more disease information.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims

1. An imaging probe is characterized by comprising an optical fiber (1), a fixed sleeve (2), a reflector (3), a sleeve shell (4), an ultrasonic transducer (5), a target surface to be detected (6) and a glass window (9), wherein excitation light transmitted by the optical fiber (1) is reflected by the reflector (3) and focused on the target surface to be detected (6), fluorescence emitted by the target surface to be detected (6) returns to the original path and is received by an optical system to form fluorescence imaging, and meanwhile, the focused light (7) can cause the target surface to be detected (6) to generate thermal expansion to generate an ultrasonic beam (8) which is received by the ultrasonic transducer (5), so that an ultrasonic signal is obtained, namely, light-excited ultrasonic imaging is formed.

2. An imaging probe according to claim 1, characterized in that said optical fiber (1) is a single mode fiber.

3. An imaging probe according to claim 1, characterized in that the excitation light transmitted by the optical fiber (1) is pulsed light with a pulse width of 10-100ns.

4. An imaging probe according to claim 1, characterized in that the sleeve housing (4) is made of metal.

5. An imaging probe according to claim 1, characterized in that said glass window (9) is made of quartz.