CN115260069A - 3,3-difluoroallylonium salt compound and preparation method and application thereof - Google Patents

3,3-difluoroallylonium salt compound and preparation method and application thereof Download PDF

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CN115260069A
CN115260069A CN202211043669.XA CN202211043669A CN115260069A CN 115260069 A CN115260069 A CN 115260069A CN 202211043669 A CN202211043669 A CN 202211043669A CN 115260069 A CN115260069 A CN 115260069A
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formula
substituted
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CN115260069B (en
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张新刚
闵巧桥
冯笑甜
高兴
任金秀
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Shanghai Institute of Organic Chemistry of CAS
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Abstract

The invention discloses a 3,3-difluoroallylium salt compound, a preparation method and application thereof. The invention provides 3,3-difluoroallylium salt as shown in formula C and a preparation method thereof; the important fluorine-containing reagent is prepared by using cheap industrial raw materials; the method can be used as an alpha, alpha-geminal difluoroallylation reagent, provides a more universal and cheap new method for alpha, alpha-geminal difluoroallylation, and has high efficiency and good application prospect.

Description

3,3-difluoroallylonium salt compound and preparation method and application thereof
Technical Field
The invention relates to a 3,3-difluoroallylonium salt compound, a preparation method and an application thereof, and in particular relates to a 3,3-difluoroallylsulfonium salt, selenonium salt and tellurium salt compound, and a preparation method and an application thereof.
Background
The alpha-aryl, heteroaryl, alkenyl, alkynyl, alkyl-alpha, alpha-difluoroallyl structural compound and the derivative building block thereof have wide application in the aspects of biological medicine, pesticide, material science and the like. For example: some of the important fluorine-containing drugs KAG-308, glecaprevir, tafluprot et al contain an α, α -difluoroallyl structure.
However, in conventional methods for synthesizing α -aryl, heteroaryl, alkenyl, alkynyl, alkyl- α, α -difluoroalkyl blocks, the blocks are typically made from the carbonyl group by DAST or Deoxyfluor (e.g., markovsi, L.N.; pahinnik, V.E.; kirsanov, A.V.Synthesis 1973,787. (b) Middleton, W.J.J.Org.Chem.1975,40,574. (c) Lal, G.S.; pez, G.P.; pesarei, R.J.; prozonic, F.M.; cheng, H.J.Org.Chem.1999,64,7048.). However, these methods generally have the disadvantages of lengthy reaction steps, poor functional group compatibility, and the need for some highly toxic fluorinating agents for some reactions.
A block synthesis method for transition metal catalyzed alpha-aryl, heteroaryl or alkenyl-alpha, alpha-difluoroalkyl structural compounds and derivatives thereof developed in the last two decades ((a) Schwaebe, m.k.; mcCarthy, j.r.; whitten, J.P. tetrahedron Lett.2000,41,791, (b) Feng, Z.; chen, F.; zhang, X.Org.Lett.2012,14,1938. (c) Belhomme, M.C.; poisson, T.; pannecouke, X.Org.Lett.2013,15,3428; (d) Taguchi, T.; kitagawa, O.; morikawa, T.; nishiwaki, T.J.; uehara, endo, H.; kobayashi, Y.tetrahedron Lett.1986,27,6103. (e) Sato, K.; omote, M.M.; andodaki, A.I.T.; budax., buxetan. U.35J.3526, buxetan, U.7. J.357. Tetrahedron, U.7. J. tetrahedron, U.7, U.S. Pat. J. tetrahedron, U.7, U.S. 3, U.S. Pat. 3, U.7, U.S. 3, to solve the difficulties of the present teachings of the present disclosure. However, these methods still exist such as: poor compatibility of functional groups, high dosage of catalyst, harsh reaction conditions and the like.
In 2014, the coupling reaction of palladium-catalyzed nucleophiles with α -bromo- α, α -difluoroallyl reagents (j.am. Chem. Soc.2014,136,1230; ZL 2013 0658890.0) simplified the synthesis of α -aryl, heteroaryl, alkenyl- α, α -difluoroallyl structures, but this reaction still has the following limitations: 1. the structural diversity of the product is still needed to be further broken through by the limitation of the synthesis of the alpha-bromo-alpha, alpha-difluoroallyl reagent; 2. because the activity of the alpha-bromo-alpha, alpha-difluoroallyl reagent is higher, the reaction is only suitable for a part of the nucleophiles of the Csp2 and is difficult to be suitable for the nucleophiles of the Csp and the Csp3 carbon class; 3. palladium catalysts are relatively expensive and it is desirable to search for less expensive and less toxic catalysts.
For alkyl- α, α -difluoroallyl structured compounds formed by α, α -difluoroallylation reaction involving a Csp3 carbon-based nucleophile, there are few suitable reagents and methods that can be efficiently implemented, and only one example of reaction involving a structurally very specific, highly activated Csp3 carbon nucleophile is reported (Nature Communication,2021,12 3257. For other types of α, α -difluoroallyl reagents (synlett.1996, 4,371, chem.pharm.Bull.1985,33 (11), 5137), the preparation method is usually complicated, and the reaction involved in the reaction is difficult to realize the broad-spectrum and high-efficiency preparation of the expected product structure due to difficult control of regioselectivity, defluorination side reaction, harsh reaction conditions, limited reaction substrates and types and the like.
Therefore, a novel alpha with various structures and adjustable reactivity is developed, the alpha-geminal difluoroallylation reagent has significant significance in applying the alpha-geminal difluoroallylation reagent to a novel alpha, alpha-geminal difluoroallylation method with wider spectrum and low cost.
Disclosure of Invention
The invention aims to overcome the defects of larger structure limitation, low reaction activity controllability, limited substrate applicability and the like of an alpha, alpha-geminal difluoroallyl reagent in the existing alpha, alpha-geminal difluoroallylic reaction. The invention aims to provide a novel alpha, alpha-geminal difluoroallylation reagent (namely 3,3-difluoroallylsulfonium salt, selenonium salt, tellurium salt and derivatives thereof) with various structures and adjustable reaction activity, and the novel alpha, alpha-geminal difluoroallylation reagent is applied to a wider spectrum and cheap novel method for alpha, alpha-geminal difluoroallylation.
The present invention solves the above-mentioned problems by the following technical means.
The invention provides 3,3-difluoroallylic onium salt as shown in formula C,
Figure BDA0003821643370000021
wherein Z = S, se or Te; x is an anion;
R 1 、R 2 、R 3 and R 4 Independently H, F, cl, br, I, C 1 -C 20 By one or more R 5 Substituted C 1 -C 20 Alkyl of (C) 1 -C 20 By one or more R 6 Substituted C 1 -C 20 Heteroalkyl group of (C) 6 -C 20 Aryl of (a) by one or more R 7 Substituted C 6 -C 20 Aryl, 5-20 membered heteroaryl or substituted with one or more R 8 Substituted 5-20 membered heteroaryl; wherein, said C 1 -C 20 The heteroatom or heteroatom group of the heteroalkyl group of (a) is selected from C (= O), S (= O) 2 、SO 2 NR 1’ R 2’ 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of hetero atoms and hetero atom groups is 1 or more; the 5-20 membered heteroaryl has heteroatoms selected from S, O, N, si, P and B, and the number of the heteroatoms is 1 or more;
or, R 1 And R 4 Together with the attached Z form: 5-20 membered heterocycloalkyl, substituted by one or more R 9 Substituted 5-20 membered heterocycloalkyl, 5-20 membered heteroaryl or substituted with one or more R 10 Substituted 5-20 membered heteroaryl; the heteroatom or heteroatom group of the 5-to 20-membered heterocycloalkyl is selected from the group consisting of C (= O), S, S (= O), S (= O) 2 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of hetero atoms and hetero atom groups is 1 or more; the heteroatom or heteroatom group of the 5-20 membered heteroaryl is selected from C (= O), S, S (= O), S (= O) 2 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of hetero atoms and hetero atom groups is 1 or more;
each R 5 、R 6 、R 7 、R 8 、R 9 And R 10 Independently F, cl, br, I, C 1 -C 20 Alkyl of (C) 3 -C 20 Cycloalkyl of, C 6 -C 20 Aryl of (C) 2 -C 20 Alkynyl of (A), C 2 -C 20 Alkenyl of, C 1 -C 20 By one or more R 1a Substituted C 1 -C 20 By one or more R 1b Substituted C 3 -C 20 By one or more R 1c Substituted C 6 -C 20 Aryl of (a), one or more R 1d Substituted C 2 -C 20 By one or more R 1e Substituted C 1 -C 20 By one or more R 1f Substituted C 2 -C 20 Alkenyl of (a); said C 1 -C 20 The heteroatom or heteroatom group of the heteroalkyl group of (A) is selected from the group consisting of C (= O), S (= O) 2 、SO 2 NR 1’ R 2’ 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of the hetero atoms and hetero atom groups is 1 or more;
each R 1’ 、R 2’ 、R 3’ And R 4’ Independently is C 1 -C 20 Alkyl of (C) 3 -C 20 Cycloalkyl of, C 6 -C 20 Aryl of (a) by one or more R 1a Substituted C 1 -C 20 By one or more R 1b Substituted C 3 -C 20 By one or more R 1c Substituted C 6 -C 20 Aryl of (a);
each R 1a 、R 1b 、R 1c 、R 1d 、R 1f And R 1e Independently F, cl, br, I, N 3 、C 1 -C 20 Alkyl of (C) 6 -C 20 Aryl of (a) or independently by three C 1 -C 4 Alkyl-substituted silane groups.
In one embodiment of the invention, the 3,3-difluoroallylium salt of formula C,
Figure BDA0003821643370000031
wherein Z = S, se or Te; x is an anion;
the R is 1 、R 2 、R 3 And R 4 Independently H, F, cl, br, I, C 1 -C 20 By one or more R 5 Substituted C 1 -C 20 Alkyl of (C) 1 -C 20 By one or more R 6 Substituted C 1 -C 20 Heteroalkyl of (a), C 6 -C 20 Aryl of (a) by one or more R 7 Substituted C 6 -C 20 Aryl, 5-20 membered heteroaryl or substituted with one or more R 8 Substituted 5-20 membered heteroaryl; wherein, said C 1 -C 20 The heteroatom or heteroatom group of the heteroalkyl group of (a) is selected from C (= O), S (= O) 2 、SO 2 NR 1’ R 2’ 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of the hetero atoms and hetero atom groups is 1 or more; the 5-20 membered heteroaryl has heteroatoms selected from S, O, N, si, P and B, and the number of the heteroatoms is 1 or more;
or, R 1 And R 4 Together with the attached Z form: 5-20 membered heterocycloalkyl, substituted by one or more R 9 Substituted 5-20 membered heterocycloalkyl, 5-20 membered heteroaryl or substituted with one or more R 10 Substituted 5-20 membered heteroaryl; the heteroatom or heteroatom group of the 5-to 20-membered heterocycloalkyl is selected from C (= O), S, S (= O), S (= O) 2 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of hetero atoms and hetero atom groups is 1 or more; the heteroatom or heteroatom group of the 5-20 membered heteroaryl is selected from C (= O), S, S (= O), S (= O) 2 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of the hetero atoms and hetero atom groups is 1 or more;
the R is 5 、R 6 、R 7 、R 8 、R 9 And R 10 Independently is F, cl, br, I, C 1 -C 20 Alkyl of (C) 3 -C 20 Cycloalkyl of (C) 6 -C 20 Aryl of (C) 2 -C 20 Alkynyl of (A), C 1 -C 20 By one or more R 1a Substituted C 1 -C 20 By one or more R 1b Substituted C 3 -C 20 By one or more R 1c Substituted C 6 -C 20 Aryl of (a), one or more R 1d Substituted C 2 -C 20 By one or more R 1e Substituted C 1 -C 20 A heteroalkyl group of (a); said C 1 -C 20 The heteroatom or heteroatom group of the heteroalkyl group of (a) is selected from C (= O), S (= O) 2 、SO 2 NR 1’ R 2’ 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of the hetero atoms and hetero atom groups is 1 or more;
each R 1’ 、R 2’ 、R 3’ And R 4’ Independently is C 1 -C 20 Alkyl of (C) 3 -C 20 Cycloalkyl of (C) 6 -C 20 Aryl of (a) by one or more R 1a Substituted C 1 -C 20 By one or more R 1b Substituted C 3 -C 20 By one or more R 1c Substituted C 6 -C 20 Aryl of (a);
each R 1a 、R 1b 、R 1c 、R 1d And R 1e Independently F, cl, br, I, N 3 、C 1 -C 20 Alkyl group of (1).
In certain preferred embodiments of the present invention, certain groups in the 3,3-difluoroallylium salt of formula C are defined as follows, and groups not mentioned are as described in any of the embodiments herein (hereinafter "in one embodiment of the present invention"), wherein,
x is a conventional anion, and may be, for example, an organic or inorganic anion commonly used in the art, such as trifluoromethanesulfonate anion, fluoroborate anion, hexafluorophosphate anion, hexafluoroantimonate anion, p-toluenesulfonate anion, fluoride anion, chloride anion, bromide anion, iodide anion, and the like.
X is a conventional anion, and may be, for example, an organic or inorganic anion commonly used in the art, such as tetraphenylborate anion, trifluoromethanesulfonate anion, fluoroborate anion, hexafluorophosphate anion, hexafluoroantimonate anion, p-toluenesulfonate anion, fluorine anion, chlorine anion, bromine anion, iodine anion, and the like.
In one aspect of the present invention, C is as defined in any one of the above 1 -C 20 Alkyl of (3), substituted C 1 -C 20 C in alkyl of (C) 1 -C 20 Is independently C 1 -C 10 Alkyl radicals, as well as C 1 -C 6 Also examples of alkyl radicals are methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, n-hexyl (n-C) 6 H 13 ) Or a tert-butyl group.
In one aspect of the present invention, C is as defined in any one of the above 1 -C 20 Alkyl of (3), substituted C 1 -C 20 C in alkyl of (A) 1 -C 20 Is independently C 1 -C 10 Alkyl radicals, as well as C 1 -C 6 Also such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl.
In one aspect of the present invention, C is as defined in any one of the above 2 -C 20 Alkynyl of (2), substituted C 2 -C 20 C in alkynyl of (A) 2 -C 20 Alkynyl of (a) is independently C 2 -C 10 Alkynyl, as another example, C 2 -C 6 Alkynyl radicals of (1) also as
Figure BDA0003821643370000041
In one aspect of the present invention, C is as defined in any one of the above 2 -C 20 Alkenyl of, substituted C 2 -C 20 C in alkenyl of (A) 2 -C 20 Is independently C 2 -C 10 Alkenyl radicals, as another example C 2 -C 6 Alkenyl radicals as also described
Figure BDA0003821643370000042
In one aspect of the present invention, C is as defined in any one of the above 1 -C 20 Heteroalkyl of (a), substituted C 1 -C 20 C in heteroalkyl of (2) 1 -C 20 Is independently-C (= O) O-hybridized C 1 -C 20 Alkyl groups of (a); for example-C (= O) OMe.
In one aspect of the present invention, C is as defined in any one of the above 1 -C 20 Heteroalkyl of (a), substituted C 1 -C 20 C in heteroalkyl of (2) 1 -C 20 Is independently-C (= O) O-or-O-hybridized C 1 -C 20 Alkyl groups of (a); for example-C (= O) OMe, -C (= O) OEt, -OCH 3 。
In one aspect of the present invention, C is as defined in any one of the above 6 -C 20 Aryl of, substituted C 6 -C 20 C in aryl of (A) 6 -C 20 Aryl of (a) is independently phenyl.
In a certain aspect of the invention, R is as defined in any of the above 1 And R 4 Together with the attached Z form: 5-20 membered heterocycloalkyl of the substituted 5-20 membered heterocycloalkyl is independently 5-10 membered heterocycloalkyl, e.g.
Figure BDA0003821643370000043
Figure BDA0003821643370000044
In a certain aspect of the invention, R is as defined in any of the above 1 And R 4 Together with the attached Z form: 5-20 membered heteroaryl of 5-20 membered heteroaryl, substituted 5-20 membered heteroaryl is independently 5-10 membered heteroaryl, e.g. benzothiophene
Figure BDA0003821643370000045
In one aspect of the present invention, C is as defined in any one of the above 3 -C 20 Cycloalkyl of (a) is independently cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.
In a certain embodiment of the invention, R is 4 Independently is C 1 -C 20 Alkyl of (2), preferably C 1 -C 6 Such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl.
In one embodiment of the present invention, R 1 、R 2 、R 3 And R 4 Independently H, F, cl, br, me, et, phenyl (ph), tolyl (Tol), methoxyphenyl, bromophenyl, tri (methyl) phenyl (e.g., 2,4,6-trimethylphenyl Mes), tri (isopropyl) phenyl (TIPP), phenylethylene, tert-butylphenyl, n-hexyl, -C (= O) OMe,
Figure BDA0003821643370000051
Figure BDA0003821643370000052
in one embodiment of the present invention, R 1 、R 2 、R 3 And R 4 Independently H, F, cl, br, me, et, phenyl (ph), tolyl (Tol), methoxyphenyl, bromophenyl, O tri (methyl) phenyl (e.g., 2,4,6-trimethylphenyl Mes), tri (isopropyl) phenyl (TIPP), phenylethylene, -C (= O) OMe,
Figure BDA0003821643370000053
In one aspect of the present inventionIn the table, R 2 Independently H, me, n-hexyl, -C (= O) OMe,
Figure BDA0003821643370000054
Figure BDA0003821643370000055
In one embodiment of the present invention, R 2 Independently H, me, -C (= O) OMe,
Figure BDA0003821643370000056
In one embodiment of the present invention, R 4 Independently Me or Et.
In one embodiment of the present invention, R 3 Independently is H, F, cl, br, -C (= O) OMe, me, phenyl, phenylethylene, methoxyphenyl, tert-butylphenyl,
Figure BDA0003821643370000057
In one embodiment of the present invention, R 3 Independently H, F, cl, br, -C (= O) OMe, me, phenyl, phenylethylene,
Figure BDA0003821643370000061
In one embodiment of the present invention, R 1 And R 4 One of them is Me or Et and the other is phenyl, tolyl, methoxyphenyl, bromophenyl, tri (methyl) phenyl, tri (isopropyl) phenyl, phenylethylene.
In one embodiment of the present invention, R 1 And R 4 Together with the attached Z form:
Figure BDA0003821643370000062
Figure BDA0003821643370000063
alkyl is independently said C 1 -C 20 By one or more R 5 Substituted C 1 -C 20 Alkyl groups of (a); for example
Figure BDA0003821643370000064
In one embodiment of the invention, the 3,3-difluoroallylic onium salt as shown in formula C is any of the following structures:
Figure BDA0003821643370000065
Figure BDA0003821643370000071
Figure BDA0003821643370000081
wherein X is as defined above; x is F, cl, br, BF 4 、OTf、BPh 4 、PF 6 、TeF 6 Or SbF 6 TIPP is tri (isopropyl) phenyl, mes is 2,4,6-trimethylphenyl, tol is tolyl, and Alkyl is independently said C 1 -C 20 By one or more R 5 Substituted C 1 -C 20 Alkyl groups of (a); ar is independently said C 6 -C 20 Aryl of (a) by one or more R 7 Substituted C 6 -C 20 Aryl of (a); r is 5 And R 7 Is defined in the present invention.
In one embodiment of the present invention, the 3,3-difluoroallylium salt represented by formula C is any one of the following compounds:
Figure BDA0003821643370000082
Figure BDA0003821643370000091
the invention provides a preparation method of 3,3-difluoroallylium salt compounds shown as a formula C, which comprises the following steps:
in an organic solvent, carrying out alkylation reaction on the compound shown in the formula D and an alkylating reagent to obtain a 3,3-difluoroallylonium salt compound shown in the formula C; the alkylating agent is R 4 X and/or R 4 Systems of I and AgX or R 4 3 OBF 4 ；
Figure BDA0003821643370000092
Wherein Z, X, R 1 、R 2 、R 3 And R 4 The definition of (a) is shown in any scheme above.
In the alkylation reaction, the alkylating reagent can be R 4 X, such as MeOTf.
In the alkylation reaction, the alkylating agent may be (R) 4 ) 3 OBF 4 For example (Et) 3 OBF 4 。
The operation and conditions of the alkylation reaction are those conventional in the art; in the present invention, it is preferable that,
in the alkylation reaction, the organic solvent may be an aprotic solvent, such as DCM, THF, DMF or DMSO.
In the alkylation reaction, the amount of the organic solvent is not particularly limited so as not to affect the reaction; in the present invention, the mass-to-volume ratio of the compound represented by the formula D to the organic solvent is preferably 0.01 to 2mol/L (for example, 0.7 to 1 mol/L).
In the alkylation reaction, the molar ratio of the compound represented by formula D to the alkylating agent may be 1:1. 1.15: 0.933 or 1:1.1.
in the alkylation reaction, the molar ratio of the compound represented by formula D to the alkylating agent may be 1.9 to 1.5, for example 1:1, 1.15.
The alkylation reaction is preferably carried out under argon or nitrogen.
The alkylation reaction is preferably carried out at a temperature of from 0 ℃ to 140 ℃, for example from 10 to 30 ℃.
In the alkylation reaction, the progress of the reaction can be monitored by conventional monitoring methods in the art (e.g., TLC or NMR), and the end point of the reaction is usually the disappearance or no longer reaction of the compound represented by formula D.
In one embodiment, the preparation method further comprises a preparation method of the compound shown in the formula D, which comprises the following steps: in an organic solvent, carrying out a substitution reaction shown as the following formula on a compound shown as a formula A and a compound shown as a formula B to obtain a compound shown as a formula D;
Figure BDA0003821643370000101
wherein Z, R 1 、R 2 And R 3 The definition of (1) is shown in any scheme above;
X 1 is F, cl or Br; m is a group of 1 Is an alkali metal.
In one embodiment, in the substitution reaction, M is 1 Is Na, K or Li.
In the substitution reaction, the operation and conditions of the substitution reaction can be the operation and conditions which are conventional in the reactions in the field; in the present invention, it is preferable that,
in the substitution reaction, the organic solvent may be an aprotic solvent, such as one or more of dioxane (dioxane), tetrahydrofuran (THF), N-Dimethylformamide (DMF), and Dimethylsulfoxide (DMSO).
In the substitution reaction, the amount of the organic solvent may not be particularly limited so as not to affect the reaction; in the present invention, the mass-to-volume ratio of the compound represented by the formula B to the organic solvent is preferably 0.01 to 2mol/L (for example, 0.7 to 1 mol/L).
In the substitution reaction, the compound represented by the formula B can be added in a conventional solution form, for example, a THF solution, for example, a 1.2M THF solution.
In the substitution reaction, the molar ratio of the compound shown in formula a to the compound shown in formula B can be 1:1 to 1:3, such as 1.
In the substitution reaction, the molar ratio of the compound shown in the formula A to the compound shown in the formula B can be 1:1-1:3, such as 1.2, 1.25, 1:2.
The substitution reaction is preferably carried out under argon or nitrogen.
The substitution reaction is preferably carried out at room temperature to 140 ℃, preferably 50 ℃ to 140 ℃, for example 100 ± 10 ℃.
In the substitution reaction, the progress of the reaction can be monitored by conventional monitoring methods in the art (e.g., TLC or NMR), and the end point of the reaction is generally the disappearance or no longer reaction of the compound represented by formula A.
The invention also provides application of the 3,3-difluoroallylium salt compound shown as the formula C as an alpha, alpha-gem-difluoroallylation reagent.
In the invention, R in the 3,3-difluoroallylonium salt compound shown by the formula C 1 Or R 4 The steric and electric effects of (2) can adjust the reaction selectivity.
In one aspect, the application comprises the following steps:
in a solvent, carrying out coupling reaction on 3,3-difluoroallylonium salt compounds shown in a formula C and a zinc reagent shown in the specification to obtain alpha, alpha-gem-difluoroallylic compounds shown in a formula E;
Figure BDA0003821643370000111
wherein Z, X, R 1 、R 2 、R 3 And R 4 The definition of (1) is shown in any scheme above;
[C]by Csp1, csp2 or Csp3 with [ Zn ]]A connected portion; [ Zn ]]Is represented by ZnX 2 、Zn·LiX 2 、ZnX 2 ·LiX 2 ；X 2 Independently bromine or chlorine.
In one embodiment, in the coupling reaction, the [ Zn ] is ZnBr, znCl, zn. LiCl, znCl. LiCl, znBr. LiCl.
The operations and conditions of the coupling reaction may be those conventional in such reactions in the art. In the present invention, the following may be preferred:
in the coupling reaction, the solvent can be an ether solvent; the ether solvent is tetrahydrofuran.
In the coupling reaction, the amount of the organic solvent is not particularly limited so as not to affect the reaction; in the present invention, the mass-to-volume ratio of the compound represented by the formula C to the organic solvent is preferably 0.01mol/L to 2mol/L (e.g., 0.1 mol/L).
In the coupling reaction, the zinc reagent may be added in the form of a conventional solution, for example, a solution of Dimethylacetamide (DMA) and/or THF, for example, a 0.1 to 1M solution of DMA and/or THF.
In the coupling reaction, the molar ratio of the 3,3-difluoroallylonium salt compound shown in the formula C to the zinc reagent can be 1:1 to 1.5; for example, 1.1, 1.2, 1.
The coupling reaction is carried out in the presence of a catalyst, which may be a cuprous halide, such as CuBr; the molar ratio of the catalyst to the 3,3-difluoroallylonium salt compound shown in the formula C can be 0.2 to 0.005; for example 0.01, 0.025, 0.05, 0.1.
The temperature of the coupling reaction may be from-78 to 35 ℃, e.g., at room temperature.
The progress of the reaction can be monitored by monitoring methods conventional in the art (e.g., TLC or NMR), and is generally at the end of the reaction when the compound of formula C is absent or no longer reacted.
In one embodiment, the 3,3-difluoroallylonium salt compound shown as formula C is
Figure BDA0003821643370000112
Figure BDA0003821643370000113
In one embodiment, in the application, the zinc reagent and the corresponding α, α -gem-difluoroallylic compound shown in formula E are any one of the following groups:
Figure BDA0003821643370000114
Figure BDA0003821643370000121
Figure BDA0003821643370000131
Figure BDA0003821643370000141
Figure BDA0003821643370000151
Figure BDA0003821643370000161
Figure BDA0003821643370000171
the onium salt can be reacted with the conventional zinc reagent under the catalysis of copper salt to obtain the expected structure containing alpha, alpha-gem-difluoroallyl.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is standard in the art to which the claimed subject matter belongs. In case there are multiple definitions for a term, the definitions herein control.
Radical definition
The following definitions as used herein should be applied unless otherwise indicated. For the purposes of the present invention, the chemical elements are in accordance with the CAS version of the periodic Table of the elements, and the handbook of chemistry and Physics, 75 th edition, 1994. In addition, general principles of Organic Chemistry can be referred to as described in "Organic Chemistry", thomas Sorrell, university Science Books, sausaltito: 1999, and "March's Advanced Organic Chemistry" by Michael B.Smith and Jerry March, john Wiley & Sons, new York:2007, the entire contents of which are incorporated herein by reference.
In the present specification, groups and substituents thereof may be selected by one skilled in the art to provide stable moieties and compounds. When a substituent is described by a general formula written from left to right, the substituent also includes chemically equivalent substituents obtained when the formula is written from right to left.
Certain chemical groups defined herein are preceded by a shorthand notation to indicate the total number of carbon atoms present in the group. E.g. C 1 -C 6 Alkyl refers to an alkyl group as defined below having a total of 1,2, 3,4, 5, or 6 carbon atoms. The total number of carbon atoms in the shorthand notation excludes carbons that may be present in a substituent of the group.
Numerical ranges defined in the substituents herein, such as 0 to 4, 1-4, 1 to 3, etc., indicate integers within the range, such as 1-6 being 1,2, 3,4, 5, 6.
In addition to the foregoing, when used in the specification and claims of this application, the following terms take the meanings indicated below, unless otherwise specifically indicated.
The term "comprising" is open-ended, i.e. comprising what is specified in the invention, but does not exclude other aspects.
The term "substituted" means that any one or more hydrogen atoms on a particular atom is replaced with a substituent, so long as the valence of the particular atom is normal and the substituted compound is stable.
In general, the term "substituted" means that one or more hydrogen atoms in a given structure are replaced with a particular substituent. Further, when the group is substituted with 1 or more of the substituents, the substituents are independent of each other, that is, the 1 or more substituents may be different from each other or the same. Unless otherwise indicated, a substituent group may be substituted at each substitutable position of the substituent group. When more than one position in a given formula can be substituted with one or more substituents selected from a particular group, the substituents may be substituted at each position, identically or differently.
In each part of this specification, substituents for the disclosed compounds are disclosed in terms of group type or range. It is specifically intended that the invention includes each and every independent subcombination of the various members of these groups and ranges. The term "C x -C y Alkyl "refers to straight or branched chain saturated hydrocarbons containing from x to y carbon atoms. For example, the term "C 1 ～C 6 Alkyl "or" C 1-6 Alkyl "means in particular independently disclosed methyl, ethyl, C 3 Alkyl radical, C 4 Alkyl radical, C 5 Alkyl and C 6 Alkyl radical (ii) a; "C 1-4 Alkyl refers specifically to independently disclosed methyl, ethyl, C 3 Alkyl (i.e. propyl, including n-propyl and isopropyl), C 4 Alkyl (i.e., butyl, including n-butyl, isobutyl, sec-butyl, and tert-butyl).
The terms "moiety," "structural moiety," "chemical moiety," "group," "chemical group" as used herein refer to a specific fragment or functional group in a molecule. Chemical moieties are generally considered to be chemical entities that are embedded in or attached to a molecule.
When none of the listed substituents indicate through which atom it is attached to a general chemical structure (including but not specifically mentioned compounds), such substituent may be bonded through any atom thereof. Combinations of substituents and/or variants thereof are permissible only if such combinations result in stable compounds.
When any variable (e.g. R) 1a ) In the definition of a compound, the occurrence at each position of the variable is defined multiple times independently of the occurrence at the remaining positions, and their meanings are independent of each other and independent of each other. Thus, if a group is substituted by 1,2 or 3R 1a Substituted by radicals, i.e. the radical may be substituted by up to 3R 1a Substituted in the position R 1a Definition of (2) and the remaining positions R 1a Are defined independently of each other. In addition, combinations of substituents and/or variables are permissible only if such combinations result in stable compounds.
When no substituent is explicitly indicated in the listed group, such group is simply referred to as unsubstituted. For example when "C 1 -C 4 When an alkyl group is defined as "not preceded" by a substituted or unsubstituted moiety, it is simply "C 1 -C 4 Alkyl "as such or" unsubstituted C 1 -C 4 Alkyl groups ".
In each of the parts of the invention, linking substituents are described. Where the structure clearly requires a linking group, the markush variables listed for that group are understood to be linking groups. For example, if the structure requires a linking group and the markush group definition for the variable recites "alkyl," it is to be understood that the "alkyl" represents a linked alkylene group.
In some specific structures, when an alkyl group is expressly indicated as a linking group, then the alkyl group represents a linked alkylene group, e.g., the group "halo-C 1 -C 6 C in alkyl 1 -C 6 Alkyl is understood to mean C 1 -C 6 An alkylene group.
The term "halogen" means fluorine, chlorine, bromine or iodine, especially F or Cl.
As a group or as part of another group (e.g. in the present application)As used in the groups haloalkyl, deuterated alkyl, and the like), the term "alkyl" is meant to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the indicated number of carbon atoms, consisting only of carbon and hydrogen atoms and being connected to the rest of the molecule by single bonds. For example having 1 to 20 (preferably 1 to 10, more preferably 1 to 6, more preferably 1 to 4) carbon atoms. Wherein propyl is C 3 Alkyl (including isomers such as n-propyl or isopropyl); butyl being C 4 Alkyl (including isomers such as n-butyl, sec-butyl, isobutyl, or tert-butyl); pentyl is C 5 Alkyl (including isomers such as n-pentyl, 1-methyl-butyl, 1-ethyl-propyl, 2-methyl-1-butyl, 3-methyl-1-butyl, isopentyl, tert-pentyl or neopentyl); hexyl is C 6 Alkyl (including isomers such as n-hexyl, 1-ethyl-2-methylpropyl, 1,1,2-trimethylpropyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2-ethylbutyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 2,3-dimethylbutyl). Examples include, but are not limited to, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, 2-methylbutyl, 2,2-dimethylpropyl, n-hexyl, n-heptyl, 2-methylhexyl, 3-methylhexyl, n-octyl, nonyl, and decyl and like alkyl groups.
As used herein, the term "alkylene" as a group or part of another group refers to a saturated divalent hydrocarbon radical derived from a saturated straight or branched chain hydrocarbon radical by the removal of two hydrogen atoms; i.e. one hydrogen of the alkyl group is substituted, the alkyl group being as defined above. Examples of alkylene groups include methylene (-CH) 2 -, ethylene { includes-CH 2 CH 2 -or-CH (CH) 3 ) - }, isopropylidene { includes-CH (CH) 3 )CH 2 -or-C (CH) 3 ) 2 - } and so on.
In this application, the term "heteroalkyl," as a group or as part of another group (e.g., as used in haloalkyl, deuterated alkyl, etc., groups), means that a O, S, N-containing moiety (in the form of a tertiary amine moiety) may be present in the alkyl group) B, P, or a heteroatom or heteroatom group of Si (e.g., C (= O), S (= O) 2 、
Figure BDA0003821643370000191
P(＝O)、P(＝O) 2 、
Figure BDA0003821643370000192
The a-terminus represents an attachment position) to provide a heteroalkyl group (e.g., an alkyl group containing one or more ether, thioether, or amino linkages). Such as alkoxy, alkylthio, and the like; illustrative examples of heteroalkyl groups include-C (= O) OMe and-CH 2 CH 2 OCH 2 CH 3 。
In this application, the term "alkoxy" as a group or part of another group means-O-alkyl, alkyl as defined above.
In this application, the term "alkylthio", as a group or as part of another group, means-S-alkyl, alkyl as defined above.
In this application, the term "alkenyl" as a group or part of another group refers to a straight or branched hydrocarbon chain radical having at least one double bond, consisting solely of carbon and hydrogen atoms, and attached to the rest of the molecule by single bonds. For example, having from 2 to 20 (preferably 2 to 10, more preferably 2 to 6, most preferably 2 to 4) carbon atoms, such as including but not limited to ethenyl, n-propenyl, isopropenyl, n-butenyl, isobutenyl, sec-butenyl, tert-butenyl, n-pentenyl, 2-methylbutenyl, 2,2-dimethylpropenyl, n-hexenyl, heptenyl, 2-methylhexenyl, 3-methylhexenyl, octenyl, nonenyl, decenyl, and the like.
In this application, the term "cycloalkyl" as a group or part of another group means a carbocyclic substituent of a saturated monocyclic or polycyclic ring (e.g., bridged, fused, or spiro ring systems of bicyclic, tricyclic, or higher rings) and which may be attached to the remainder of the molecule by a single bond via any suitable carbon atom. For example, a 3-20 membered cycloalkyl group having 3 to 20 carbon atoms, preferably a 3-10 membered cycloalkyl group having 3 to 10 carbon atoms, more preferably a 3-7 membered cycloalkyl group having 3 to 7 carbon atoms, and most preferably a 3-6 membered cycloalkyl group having 3 to 6 carbon atoms. In one embodiment, a monocyclic cycloalkyl group is typically, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or cycloheptyl.
In this application, the term "heterocycloalkyl" as a group or as part of another group refers to a group having one or more heteroatoms or heteroatom groups consisting of carbon atoms and 1 or more members selected from O, S, N (in the form of a tertiary amine moiety), B, P or Si (e.g., C (= O), S (= O) 2 、
Figure BDA0003821643370000201
P(＝O)、P(＝O) 2 、
Figure BDA0003821643370000202
The a-terminal represents the attachment position) to a stable saturated heterocyclic hydrocarbon group. For example from 2 to 20, preferably 2 to 6, carbon atoms and from 1 to 6 carbon atoms selected from C (= O), S, S (= O), S (= O) 2 、O、N、Si、P、P(＝O)、P(＝O) 2 And B, a heteroatom or heteroatom group, is a stable 3 to 26 membered (preferably 3 to 20 membered, more preferably 4 to 10 membered, most preferably 3 to 7 membered) saturated heterocyclic hydrocarbon group; preferably a 4-10 membered saturated monocyclic or polycyclic (e.g. bicyclic, tricyclic or higher bridged, fused (fused) or spiro ring system) heterocyclic hydrocarbon group containing 1,2 or 3 ring heteroatoms independently selected from N, O and S. The ring system of the heterocycloalkyl bicyclic ring may include one or more heteroatoms in one or both rings; and is saturated. In some embodiments, "heterocycloalkyl" is a 5 to 7 membered monocyclic heterocycloalkyl, a 6 to 8 membered ring-linked heterocycloalkyl, a 6 to 8 membered bridged ring-linked heterocycloalkyl, or a 7 to 10 membered spiro ring-linked heterocycloalkyl.
In the present application, the term "aryl" as a group or as part of another group means a conjugated hydrocarbon ring system group that satisfies the rule of 4n + 2. Such as a conjugated hydrocarbon ring system group having 6 to 20 carbon atoms (preferably having 6 to 10 carbon atoms) that satisfies the rule of 4n + 2. For the purposes of the present invention, an aryl group may be a monocyclic, bicyclic, tricyclic or higher polycyclic ring system and may also be fused to a cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl group as defined above, provided that the aryl group is attached to the remainder of the molecule by a single bond via an atom on the aromatic ring. In one embodiment, the term "aryl" refers to an aromatic group consisting of carbon atoms, each ring having aromatic character. Examples of aryl groups include, but are not limited to, phenyl, naphthyl.
In this application, the term "heteroaryl" as a group or part of another group means a heteroatom or heteroatom group (e.g., C (= O), S (= O) having carbon atoms and heteroatoms and heteroatom groups in the ring selected from O, S, N (in the form of a tertiary amine moiety), B, P, or Si 2 、
Figure BDA0003821643370000203
P(＝O)、P(＝O) 2 、
Figure BDA0003821643370000204
End a represents the attachment position). For example, having from 1 to 20 carbon atoms (preferably from 1 to 10 carbon atoms) and from 1 to 6 heteroatoms and heteroatom groups in the ring selected from C (= O), S, S (= O), S (= O) 2 、O、N、Si、P、P(＝O)、P(＝O) 2 And a 5 to 26 membered conjugated ring system group of B. Unless otherwise specifically indicated in the specification, a heteroaryl group may be a monocyclic, bicyclic, tricyclic or higher ring system, and may also be fused to a cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl group as defined above, provided that the heteroaryl group is attached to the rest of the molecule by a single bond via an atom on the aromatic ring. For the purpose of the present invention, the heteroaryl group is preferably a stable 5 to 20-membered aromatic group containing 1 to 5 heteroatoms selected from nitrogen, oxygen and sulfur, and further preferably a stable 5 to 10-membered aromatic group containing 1 to 5 heteroatoms selected from nitrogen, oxygen and sulfur. In one aspect, the term "heteroaryl" refers to an aromatic group containing heteroatoms, each ring having aromatic character; preferably an aromatic 5-6 membered monocyclic or 9-10 membered bicyclic ring containing 1,2 or 3 heteroatoms independently selected from nitrogen, oxygen and sulfur.
It should be understood that as used herein, singular forms, such as "a", "an", include plural references unless the context clearly dictates otherwise.
The term "one or more" or "one or more" means 1,2, 3,4, 5, 6, 7, 8, 9 or more.
The present invention employs conventional methods of mass spectrometry, elemental analysis, and the various steps and conditions can be referred to those conventional in the art unless otherwise indicated.
Unless otherwise indicated, the present invention employs standard nomenclature for analytical chemistry, organic synthetic chemistry, and optics, and standard laboratory procedures and techniques. In some cases, standard techniques are used for chemical synthesis, chemical analysis, light emitting device performance detection.
In addition, it should be noted that, unless otherwise explicitly indicated, the description of "… is independently" as used in the present invention is to be understood in a broad sense, meaning that each individual species so described is independent of the other and may be independently the same or different specific groups. In more detail, the description "… is independently" can mean that the specific options expressed between the same symbols do not affect each other in different groups; it can also be said that in the same group, the specific options expressed between the same symbols do not affect each other.
It will be understood by those skilled in the art that, in accordance with the convention used in the art, the structural formulae used in the radicals described herein
Figure BDA0003821643370000211
And
Figure BDA0003821643370000212
means that the corresponding group R is linked to other fragments, groups in the compound via this site.
It will be understood by those skilled in the art that, in accordance with the convention used in the art, the structural formulae used in the radicals described herein
Figure BDA0003821643370000213
Represents a single bond or a double bond.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is standard in the art to which the claimed subject matter belongs. In case there are multiple definitions for a term, the definitions herein control.
The above preferred conditions can be arbitrarily combined to obtain preferred embodiments of the present invention without departing from the common general knowledge in the art.
The reagents and starting materials used in the present invention are commercially available.
The positive progress effects of the invention are as follows: the 3,3-difluoroallylic onium salt shown in the formula C provided by the invention can be used as an alpha, alpha-gem-difluoroallylation reagent, provides a novel method with wider spectrum and lower cost for alpha, alpha-gem-difluoroallylation, and has high efficiency and better application prospect.
Detailed Description
The invention is further illustrated by the following examples, which are not intended to limit the scope of the invention. The experimental methods without specifying specific conditions in the following examples were selected according to the conventional methods and conditions, or according to the commercial instructions.
In the present invention, room temperature (RT or RT means room temperature) means ambient temperature, and is 10 ℃ to 35 ℃. Overnight means 8-15 hours. Reflux refers to the reflux temperature of the solvent at atmospheric pressure. The zinc reagents and thioethers used in the present application can be prepared by methods conventional in the art and can also be prepared by methods described in the present application. The anhydrous and oxygen-free conditions described herein, unless otherwise specified, refer to reactions carried out under protective gas, for example, in Argon (Argon or Ar means Argon). Temperatures are expressed herein in degrees Celsius (. Degree. C.), and specifically as ". Degree.C.", "degree" or "degree".
Example 1
Figure BDA0003821643370000221
Sodium hydrogen (130mmol, 5.2g) was added to a 100mL three-necked flask in the absence of water and oxygen, 250mL of 1 was added under Ar protection,4-Dioxane (Dioxane means 1,4 Dioxane or Dioxane), placing the reaction system in an ice-water bath, preparing thiophenol (100mmol, 12.4 g) into Dioxane solution, slowly dripping the thiophenol into the reaction system (system caking), placing the reaction system in an ultrasonic wave for 20min, then placing the reaction system in the ice-water bath, quickly adding bromodifluoropropylene (13.6 ml), and slowly returning to room temperature for reaction for 1h. Adding saturated ammonium chloride into the obtained reaction liquid for quenching, adding the reaction liquid until white solid disappears in a reaction system, then performing rotary evaporation to remove dioxane, extracting the residual liquid with diethyl ether for three times, combining diethyl ether phases, performing rotary drying, and passing through a column. Pure PE column chromatography gave 16.13g of yellow liquid with 80.6% yield. 1 H NMR(400MHz,CDCl3)δ7.29(d,J＝8.2Hz,2H),7.12(d,J＝8.2Hz,2H),4.35(dtd,J＝24.0,8.4,1.6Hz,1H),3.45(dt,J＝8.4,1.6Hz,2H),2.33(s,3H). 19 F NMR(376MHz,CDCl3)δ-86.63(d,J＝38.9Hz,1F),-88.68(ddt,J＝39.0,24.0,1.6Hz,1F). 13 C NMR(126MHz,CDCl3)δ157.1(dd,J＝290.1,288.8Hz),137.2,131.4,130.9,129.7,76.4(dd,J＝24.7,19.0Hz),28.0(d,J＝6.1Hz),21.0.MS(EI):m/z(％)77,123,200(100)([M]+).HRMS(EI)m/z:([M]+)Calculated for C10H10F2S:200.0466；Found:200.0470.
Example 2
Figure BDA0003821643370000222
Sodium hydroxide (52.5mmol, 2.1g) was added to a 300mL reaction vessel in the absence of water and oxygen to prepare a dioxane solution from thiophenol (50mmol, 6.21g), and the solution was slowly added dropwise to the reaction system, then, the reaction mixture was placed in an ice-water bath, purged again, and trifluoropropene was rapidly added under argon (Ar) to obtain a dioxane solution (1.0M, 150mL) and reacted at 120 ℃ for 15 hours. Adding saturated ammonium chloride for quenching, adding the saturated ammonium chloride until white solid in a reaction system disappears, then performing rotary evaporation to remove dioxane, extracting the residual liquid with diethyl ether for three times, combining diethyl ether phases, performing rotary drying, and performing pure PE column chromatography to obtain a product 8.18g, wherein the purity is 89%, and the yield is 72%.
Example 3
Figure BDA0003821643370000223
Thioether (100mmol, 20.25g, 1.12equiv) and extra dry Dichloromethane (DCM) were added to a 100mL round-bottomed flask under anhydrous and oxygen-free conditions, followed by addition of methyl trifluoromethanesulfonate (MeOTf, 9.3mL,89mmol, 1.0equiv) and reaction at room temperature (RT, RT means room temperature) overnight. And dropwise adding diethyl ether until a solid is separated out, continuously adding diethyl ether, stirring, filtering, washing with diethyl ether for three times to obtain a product, wherein the white solid is 31.35g, and the yield is 97.4%. 1 H NMR(400MHz,Chloroform-d)δ7.83(d,J＝6.3Hz,2H),7.48(d,J＝7.8Hz,2H),4.67–4.35(m,3H),3.39(s,3H),2.48(s,3H). 13 C NMR(101MHz,Chloroform-d)δ162.55–156.34(m),135.08,131.22,130.85,122.06,68.65(dd,J＝31.8,17.3Hz),42.11(d,J＝8.1Hz),25.21.MS(EI):m/z(％)153.1(100),215.1(M + ).HRMS:Calculated for C 10 H 13 F 2 S:215.0701；Found:215.0702.
Example 4
Figure BDA0003821643370000231
In the absence of water and oxygen, diphenyl disulfide (8.8g, 40mmol) was added to a 100mL three-necked flask and the gas was purged three times, 30mL of ultra-dry n-Hexane (Hexane) was added under argon (Ar), the flask was placed in a water bath at room temperature (RT: room temperature), then n-butyllithium (16.0mL of a 2.5M solution of n-Hexane (Hexane), 40 mmol) was added dropwise to the syringe (a large amount of white solid was produced, the reaction was exothermic, and the reaction was stopped when the temperature of the flask was lowered to room temperature). After the reaction is finished, adding ether for dilution, directly filtering in a fume hood, washing with ether for three times, transferring the solid to a 100mL Schlenk bottle, draining, adding 20mL Tetrahydrofuran (THF) for short, stirring (the solid is completely dissolved), placing in a room-temperature water bath, quickly adding bromodifluoropropene (7.85g, 50mmol), stirring for reaction overnight, adding water for quenching, removing THF by rotation, extracting with ether for three times, combining drying and spin-drying, and carrying out column chromatography to obtain 3.86g of light yellow liquid with the yield of 52%.
Example 5
Figure BDA0003821643370000232
Under anhydrous and oxygen-free conditions, adding diphenyl diselenide (12.49g, 40mmol) into a 100mL three-necked bottle, vacuumizing for three times, adding 30mL of super-dry n-hexane under Ar, placing in a Room Temperature (RT) water bath, then dropwise adding n-butyllithium (16.0mL, 2.5M n-hexane solution, 40 mmol) into a syringe, (a large amount of white solid is generated, the reaction is exothermic, and the reaction can be stopped when the temperature of the reaction bottle is reduced to room temperature). After the reaction is finished, adding ether for dilution, directly filtering in a fume hood, washing with ether for three times, transferring the solid to a 100mL Schlenk bottle, draining, adding 20mL THF, stirring (completely dissolving the solid), placing in a room-temperature water bath, quickly adding bromodifluoropropylene (7.85g, 50mmol), stirring for reaction overnight, adding water for quenching, spinning off THF, extracting with ether for three times, combining drying and spinning, and performing column chromatography to obtain 5.0g of the product with the yield of 54%.
Example 6
Figure BDA0003821643370000233
Under anhydrous and anaerobic conditions, adding diphenyl ditelluride (16.4g, 40mmol) into a 100mL three-necked bottle, pumping gas for three times, adding 30mL ultra-dry n-hexane under Ar, placing in a room-temperature water bath, then dropwise adding n-butyllithium (16.0mL, 2.5M n-hexane solution, 40 mmol) into a syringe, (a large amount of white solid is generated, the reaction is exothermic, and the reaction can be stopped when the temperature of the reaction bottle is reduced to room temperature). After the reaction is finished, adding ether for dilution, directly filtering in a fume hood, washing with ether for three times, transferring the solid to a 100mL Schlenk bottle, draining, adding 20mL THF, stirring (the solid is completely dissolved), placing in a room-temperature water bath, quickly adding bromodifluoropropene (7.85g, 50mmol), stirring for reaction overnight, adding water for quenching, spinning off the THF, extracting with ether for three times, combining drying and spinning, and performing column chromatography to obtain 6.54g with the yield of 58%.
Example 7
Figure BDA0003821643370000234
Under anhydrous and oxygen-free conditions, adding diphenyl diselenide (12.49g, 40mmol) into a 100mL three-necked bottle, pumping for three times, adding 30mL of ultra-dry n-hexane under Ar, placing in a room-temperature water bath, then dropwise adding n-butyllithium (16.0mL, 2.5M n-hexane solution, 40 mmol) into an injector, (a large amount of white solid is generated, the reaction is exothermic, and the reaction can be stopped when the temperature of the reaction bottle is reduced to room temperature). After the reaction was completed, the mixture was diluted with ether, filtered directly in a fume hood, washed with ether three times, and the solid was transferred to a 100mL sealed tube, drained, added with 20mL dioxane, stirred (the solid was completely dissolved), placed in a room temperature water bath, and a trifluoropropene THF solution (1.2M, 12.5 mL) was added rapidly to react at 100 ℃ for five hours. Adding saturated ammonium chloride for quenching, adding the saturated ammonium chloride until white solid in a reaction system disappears, then performing rotary evaporation to remove dioxane, extracting the residual liquid with diethyl ether for three times, combining diethyl ether phases, performing rotary drying, and performing pure PE column chromatography to obtain 4.44g of a product with the yield of 48%.
Example 8
Figure BDA0003821643370000241
Under anhydrous and anaerobic conditions, adding diphenyl ditelluride (16.4g, 40mmol) into a 100mL three-necked bottle, pumping gas for three times, adding 30mL ultra-dry n-hexane under Ar, placing in a room-temperature water bath, then dropwise adding n-butyllithium (16.0mL, 2.5M n-hexane solution, 40 mmol) into a syringe, (a large amount of white solid is generated, the reaction is exothermic, and the reaction can be stopped when the temperature of the reaction bottle is reduced to room temperature). After the reaction was completed, the mixture was diluted with ether, filtered directly in a fume hood, washed with ether three times, and the solid was transferred to a 100mL sealed tube, drained, added with 20mL dioxane, stirred (the solid was completely dissolved), placed in a room temperature water bath, and a trifluoropropene THF solution (1.2M, 12.5 mL) was added rapidly to react at 100 ℃ for five hours. Adding saturated ammonium chloride for quenching, adding into the reaction system until white solid disappears, then performing rotary evaporation to remove dioxane, extracting the rest liquid with diethyl ether for three times, combining diethyl ether phases, performing rotary drying, and performing pure PE column chromatography to obtain a product 5.45g, wherein the yield is 45%.
Example 9
Figure BDA0003821643370000242
Thioether (6.7 mmol,1.25g, 1.1equiv) was added to a 100mL three-necked flask in the absence of water and oxygen, ultra-dry DCM (10 mL) was added, and MeOTf (0.62mL, 6.1mmol,1.0 equiv) was added under an ice-water bath, and the mixture was allowed to naturally warm to room temperature for 12 hours. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of n-hexane layer is very weak, spin-drying methanol, and pumping to obtain 1.69g of viscous liquid. 1 H NMR(400MHz,Chloroform-d)δ7.96(d,J＝7.9Hz,2H),7.75(t,J＝7.4Hz,1H),7.66(t,J＝7.7Hz,2H),4.60–4.39(m,3H),3.38(s,3H). 19 FNMR(376MHz,Chloroform-d)δ-75.98(d,J＝14.1Hz),-78.56(s),-79.09(dd,J＝20.7,14.2Hz). 13 C NMR(101MHz,Chloroform-d)δ162.55–156.34(m),135.08,131.22,130.85,122.06,68.65(dd,J＝31.8,17.3Hz),42.11(d,J＝8.1Hz),25.21.MS(EI):m/z(％)201.1(100),243.1(M + ).HRMS:Calculated for C 10 H 11 F 2 S:201.0544；Found:201.0544。
Example 10
Figure BDA0003821643370000243
Selenoether (7mmol, 1.63g, 1.15equiv) was added to a 100mL three-necked flask in the absence of water and oxygen, ultra-dry DCM (10 mL) was added, and MeOTf (0.62mL, 6.1mmol, 1.0equiv) was added under an ice-water bath, and the mixture was allowed to naturally warm to room temperature and reacted for 12 hours. And (3) spin-drying, adding methanol for dissolving, washing (layering) by using n-hexane until the fluorescence of the n-hexane layer is extremely weak, and spin-drying and suction-drying the methanol to obtain 2.20g of a target product.
Example 11
Figure BDA0003821643370000251
Tellurium ether (7mmol, 1.97g, 1.15equiv) was added to a 100mL three-necked flask in the absence of water and oxygen, extra dry DCM (10 mL) was added, and MeOTf (0.62mL, 6.1mmol,1.0 equiv) was added in an ice-water bath and allowed to naturally warm to room temperature for 12 hours. And (3) spin-drying, adding methanol for dissolving, washing (layering) with n-hexane until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and pumping to obtain 2.38g of a target product.
Example 12
Figure BDA0003821643370000252
Sodium hydrogen (26mmol, 1.04g, (60% dispersed in liquid paraffin)) was added to a 100mL three-necked flask in the absence of water and oxygen, then super-dried n-hexane (about 2.5mL, solids flooded) was added to remove oil on the surface of the sodium hydrogen, (stirring for two minutes, standing, syringe to remove n-hexane, repeat three times, last pump to dry) the reaction system in an ice-water bath, thiophenol (20mmol, 3.0 g) was formulated as dioxane solution, slowly added dropwise to the reaction system (system caked), then stoppered and sonicated for 20min, then placed in an ice-water bath and the gas was re-pumped, trifluoropropene THF solution (1.2M, 33.3mL) was added rapidly under Ar, and reacted at 100 ℃ for five hours. Adding saturated ammonium chloride for quenching, adding the mixture until white solid in a reaction system disappears, then performing rotary evaporation to remove dioxane, extracting the residual liquid with diethyl ether for three times, combining diethyl ether phases, performing rotary drying, and performing pure PE column chromatography to obtain a product with the yield of 33.5%. 1 H NMR(400MHz,Chloroform-d)δ6.93(s,2H),4.29(dtd,J＝23.9,8.4,1.5Hz,1H),3.22(dt,J＝8.4,1.6Hz,2H),2.50(s,6H),2.27(s,3H). 19 F NMR(376MHz,Chloroform-d)δ-86.94(d,J＝37.8Hz),-89.68(dd,J＝39.4,24.1Hz). 13 C NMR(101MHz,Chloroform-d)δ155.69(m),143.17,138.57,129.03,128.87,128.63,27.81(d,J＝5.9Hz),21.87,21.41,21.01.MS(EI):m/z(％)151(100),228(M + ).HRMS:Calculated for C 10 H 13 F 2 S:228.0779；Found:215.0785。
Example 13
Figure BDA0003821643370000253
Adding into 50mL round bottom bottle under anhydrous and oxygen-free conditionsThioether (6.7 mmol, 1.53g), super-dried DCM (10 ml) was added, and meOTf (0.64ml, 6.4 mmol) was added under ice-water bath and allowed to naturally warm to room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of n-hexane layer is very weak, spin-drying methanol, and pumping to obtain viscous liquid. The resulting product was purified by column chromatography (DCM: meOH = 10). 1 H NMR(400MHz,Chloroform-d)δ7.07(s,2H),4.76–4.47(m,3H),3.47(s,3H),2.59(s,6H),2.34(s,3H). 19 F NMR(3＝76MHz,Chloroform-d)δ-76.58(d,J＝16.6Hz),-80.12(dd,J＝22.5,17.1Hz). 13 C NMR(101MHz,Chloroform-d)δ162.70–155.93(m),146.36,132.40,128.92,114.71,69.62(dd,J＝31.6,17.2Hz),38.98(d,J＝8.1Hz),25.68,21.59,21.26,21.23.MS(EI):m/z(％)243.1(100),315.1(M + ).HRMS:Calculated for C 10 H 13 F 2 S:243.1014；Found:243.1015。
Example 14
Figure BDA0003821643370000261
Adding sodium hydrogen (13mmol, 0.52g, (60% dispersed in liquid paraffin)) into a 100mL three-necked bottle under anhydrous and oxygen-free conditions, adding ultra-dry n-hexane (about 2.5mL, submerging the solid) to remove oil on the surface of the sodium hydrogen, (stirring for two minutes, standing, removing the n-hexane by using a syringe, repeating for three times, and finally draining) the reaction system is placed in an ice-water bath, preparing thiophenol (10mmol, 2.36g) into dioxane solution, slowly dropping the solution into the reaction system (system agglomeration), plugging the reaction system, performing ultrasonic treatment for 20min, then placing the reaction system in an ice-water bath, re-evacuating the gas, quickly adding difluorobromopropylene (2.62g, 16.7mmol) under Ar, and reacting at 100 ℃ for five hours. Adding saturated ammonium chloride for quenching, adding the mixture until white solid in a reaction system disappears, then performing rotary evaporation to remove dioxane, extracting the residual liquid with diethyl ether for three times, combining diethyl ether phases, performing rotary drying, and performing pure PE column chromatography to obtain a product with the yield of 36%. 1 H NMR(400MHz,Chloroform-d)δ7.01(s,2H),4.33(dt,J＝24.0,8.3Hz,1H),4.00–3.83(m,2H),3.20(d,J＝8.4Hz,2H),2.88(p,J＝7.2Hz,1H),1.24(s,18H). 19 F NMR(376MHz,Chloroform-d)δ-86.62(d,J＝38.8Hz),-89.08(dd,J＝38.7,24.0Hz). 13 C NMR(101MHz,Chloroform-d)δ160.66–153.89(m),153.27,150.02,127.00,121.81,76.15(dd,J＝24.6,19.4Hz),34.28,31.56,30.10(d,J＝5.9Hz),24.39,23.89.
Example 15
Figure BDA0003821643370000262
Adding sodium hydrogen (26mmol, 1.04g, (60% dispersed in liquid paraffin)) into a 100mL sealed tube under anhydrous and oxygen-free conditions, then adding ultra-dry n-hexane (about 2.5mL, submerging the solid) to remove oil on the surface of the sodium hydrogen, (stirring for two minutes, standing, pumping out the n-hexane by using an injector, repeating for three times, and pumping out for the last time), placing the reaction system into an ice-water bath, preparing thiophenol (20mmol, 2.8g) into a dioxane solution, slowly dropwise adding the solution into the reaction system (agglomeration system), plugging the reaction system, placing the reaction system into an ultrasonic device for 20min, then placing the reaction system into the ice-water bath, pumping out the gas again, quickly adding bromodifluoropropylene (4.19g, 26.7mmol) under Ar, and reacting for five hours at 100 ℃. Adding saturated ammonium chloride for quenching, adding into the reaction system until white solid disappears, then performing rotary evaporation to remove dioxane, extracting the rest liquid with diethyl ether for three times, combining diethyl ether phases, performing rotary drying, and performing pure PE column chromatography to obtain a product 3.45g, wherein the yield is 80%. 1 H NMR(400MHz,Chloroform-d)δ7.01(s,2H),4.33(dt,J＝24.0,8.3Hz,1H),4.00–3.83(m,2H),3.20(d,J＝8.4Hz,2H),2.88(p,J＝7.2Hz,1H),1.24(s,18H). 19 F NMR(376MHz,Chloroform-d)δ-86.62(d,J＝38.8Hz),-89.08(dd,J＝38.7,24.0Hz). 13 C NMR(101MHz,Chloroform-d)δ160.66–153.89(m),153.27,150.02,127.00,121.81,76.15(dd,J＝24.6,19.4Hz),34.28,31.56,30.10(d,J＝5.9Hz),24.39,23.89.
Example 16
Figure BDA0003821643370000271
Into a 50mL round-bottomed flask in the absence of water and oxygen (e.g., in Argon, argon or Ar means Argon)To this was added thioether (1.5mmol, 0.32g), super-dried DCM (0.5 ml) and then MeOTf (0.14ml, 1.4mmol) and reacted at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the n-hexane layer has weak fluorescence, spin-drying methanol, and suction-drying to obtain 0.45g viscous liquid with yield of 82%. 1 H NMR(400MHz,Chloroform-d)δ7.88(d,J＝8.9Hz,2H),7.15(d,J＝9.0Hz,2H),4.69–4.34(m,3H),3.91(s,3H),3.36(s,3H). 19 F NMR(376MHz,Chloroform-d)δ-75.88(d,J＝14.3Hz),-78.94–-79.39(m). 13 C NMR(101MHz,Chloroform-d)δ162.55–156.34(m),135.08,131.22,130.85,122.06,68.65(dd,J＝31.8,17.3Hz),42.11(d,J＝8.1Hz),25.21.MS(EI):m/z(％)231.1(100),233.1(M + ).HRMS:Calculated for C 10 H 13 F 2 S:231.0650；Found:231.0652。
Example 17
Figure BDA0003821643370000272
Adding sodium hydrogen (26mmol, 1.04g, (60% dispersed in liquid paraffin)) into a 50mL round-bottomed bottle under anhydrous and oxygen-free conditions, then adding ultra-dry n-hexane (about 2.5mL, submerging the solid) to remove oil on the surface of the sodium hydrogen, (stirring for two minutes, standing, pumping out the n-hexane by using an injector, repeating for three times, and finally pumping out) to obtain a reaction system, placing the reaction system in an ice-water bath, preparing thiophenol (20mmol, 2.8g) into a dioxane solution, slowly dropwise adding the solution into the reaction system (system agglomeration), plugging the reaction system, performing ultrasonic treatment for 20min, then placing the reaction system in the ice-water bath, pumping out the gas again, quickly adding bromodifluoropropylene (4.19g, 26.7mmol) under Ar, and reacting for five hours at 100 ℃. Adding saturated ammonium chloride for quenching, adding the mixture into a reaction system until white solid disappears, then removing dioxane by rotary evaporation, the remaining liquid is extracted three times by ether, ether phases are combined, spin-dried and purified PE column chromatography is carried out to obtain 3.7g of product, and the yield is 85%. 1 H NMR(400MHz,Chloroform-d)δ7.01(s,2H),4.33(dt,J＝24.0,8.3Hz,1H),4.00–3.83(m,2H),3.20(d,J＝8.4Hz,2H),2.88(p,J＝7.2Hz,1H),1.24(s,18H). 19 F NMR(376MHz,Chloroform-d)δ-86.62(d,J＝38.8Hz),-89.08(dd,J＝38.7,24.0Hz). 13 C NMR(101MHz,Chloroform-d)δ160.66–153.89(m),153.27,150.02,127.00,121.81,76.15(dd,J＝24.6,19.4Hz),34.28,31.56,30.10(d,J＝5.9Hz),24.39,23.89.
Example 18
Figure BDA0003821643370000273
Thioether (10.7 mmol, 2.32g) was added to a 50mL round bottom flask in the absence of water and oxygen, ultra-dry DCM (1.5 mL) was added, and MeOTf (1.03mL, 9.75mmol) was added and the reaction was allowed to proceed at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 3.9g of viscous liquid with a yield of 92%. 1 H NMR(400MHz,Chloroform-d)δ7.86–7.56(m,1H),7.23(t,J＝7.7Hz,1H),7.15(d,J＝8.4Hz,1H),4.68–4.41(m,3H),4.06(s,3H),3.37(s,3H). 19 F NMR(376MHz,Chloroform-d)δ-76.12(d,J＝16.2Hz),-78.48,-80.35(dd,J＝23.7,16.3Hz). 13 C NMR(101MHz,Chloroform-d)δ162.51–156.50(m),159.42,137.24,132.99,122.67,113.07,107.56,68.90(dd,J＝31.4,17.3Hz),56.79,38.84(d,J＝8.1Hz),23.11.MS(EI):m/z(％)153.1(100),215.1(M + ).HRMS:Calculated for C 10 H 13 F 2 S:231.0650；Found:231.0651。
Example 18-1
Figure BDA0003821643370000281
Thioether (10mmol, 2.32g) was added to a 50mL round-bottomed flask in the absence of water and oxygen, and ultra-dry DCM (15 mL) was added, followed by triethyloxonium tetrafluoroborate (2.09g, 111mmol) and reacted at room temperature for 36 hours. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the n-hexane layer has weak fluorescence, spin-drying methanol, and suction-drying to obtain 1.5g of viscous liquid with a yield of 45%. 1 HNMR(400MHz,Chloroform-d)δ7.80–7.72(m,2H),7.27-7.19(m,2H),4.85–4.65(m,2H),4.07(s,3H),3.99-3.83(m，2H),1.36and 1.21(t,J＝8.0Hz,3H). 19 F NMR(376MHz,Chloroform-d)δ-76.6and 77.0(d,J＝14.9Hz),-80.5and 80.9(dd,J＝23.7,14.9Hz)，-148.5，-151.4.
Example 19
Figure BDA0003821643370000282
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then, the mixture was cooled again in an ice-water bath, bromodifluoropropene (25mmol, 3.98g) was slowly added thereto, and after the dropwise addition, the mixture was naturally warmed to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 4.88g of product, and the isolated yield is 92%. 1 H NMR(400MHz,Chloroform-d)δ7.87(d,J＝8.3Hz,2H),7.80(d,J＝8.9Hz,2H),4.59–4.43(m,3H),3.39(d,J＝2.3Hz,3H).19F NMR(376MHz,Chloroform-d)δ-75.27(dd,J＝13.2,9.1Hz),-78.51(ddd,J＝19.1,13.1,6.8Hz). 13 C NMR(101MHz,Chloroform-d)δ163.28–155.65(m),134.51,132.34,130.69,121.02,120.43(q,J＝319.5Hz),68.52(dd,J＝31.7,17.4Hz),42.14(d,J＝8.1Hz),25.34.MS(EI):m/z 279.0(％)(100),351.0(M + ).HRMS:Calculated for C 10 H 10 F 2 SBr:278.9643；Found:278.9649。
Example 20
Figure BDA0003821643370000283
Thioether (12.2mmol, 3.24g) was added to a 50mL round bottom flask in the absence of water and oxygen, and ultra dry DCM (10 mL) was added followed by MeOTf (1.2mL, 11.2mmol) and reacted at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 4.39g of viscous liquid with the yield of 91.5%. 1 H NMR(400MHz,Chloroform-d)δ7.87(d,J＝8.3Hz,2H),7.80(d,J＝8.9Hz,2H),4.59–4.43(m,3H),3.39(d,J＝2.3Hz,3H).19F NMR(376MHz,Chloroform-d)δ-75.27(dd,J＝13.2,9.1Hz),-78.51(ddd,J＝19.1,13.1,6.8Hz). 13 C NMR(101MHz,Chloroform-d)δ163.28–155.65(m),134.51,132.34,130.69,121.02,120.43(q,J＝319.5Hz),68.52(dd,J＝31.7,17.4Hz),42.14(d,J＝8.1Hz),25.34.MS(EI):m/z 279.0(％)(100),351.0(M + ).HRMS:Calculated for C 10 H 10 F 2 SBr:278.9643；Found:278.9649。
Example 21
Figure BDA0003821643370000291
NaH (9.0 g,60%,225 mmol) was added to a 1000mL reaction flask in an anhydrous oxygen-free ice water bath, followed by washing three times (60 mL each) with n-pentane to remove kerosene in sodium hydride, the resulting active sodium hydride was suspended in 500mL of ultra-dry dioxane, and then thiophenol (22.4 g,180.0 mmol) was slowly added dropwise in an ice water bath, followed by stirring at room temperature for reaction for 60 minutes after completion of the addition. Then, the mixture was cooled again in an ice-water bath, bromotrifluoropropene (360mmol, 63g) was slowly added thereto, and after the dropwise addition, the mixture was naturally raised to 25 ℃ and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 43.1g of product, and the isolated yield is 82%. 1 H NMR(400MHz,CDCl 3 )δ7.36(d,J＝8.0Hz,2H),7.13(d,J＝8.0Hz,2H),3.72–3.69(m,2H),2.34(s,3H). 19 F NMR(376MHz,CDCl 3 )δ-81.91(dt,J＝34.9,2.0Hz,1F),-87.65(dt,J＝34.9,2.7Hz,1F). 13 C NMR(101MHz,CDCl 3 )δ154.1(dd,J＝291.3,287.1Hz),138.3,133.3,129.8,129.5,78.4(dd,J＝37.0,22.1Hz),37.7,21.1.MS(FI):m/z(％)280(100)([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 10 H 9 BrF 2 S:277.9571；Found:277.9575.
Example 22
Figure BDA0003821643370000292
Thioether (16.5mmol, 4.6 g) was added to a 100mL three-necked flask in the absence of water and oxygen, and ultra-dry DCM (10 mL) was added followed by MeOTF (2.5g, 15mmol) and allowed to react at room temperature for 4h. And (3) spin-drying, adding methanol for dissolving, washing (layering) by using normal hexane until the fluorescence of the normal hexane layer is extremely weak, then spin-drying the methanol, and recrystallizing by using diethyl ether to obtain 5.5g of white solid with the yield of 83%. 1 H NMR(400MHz,CDCl 3 )δ7.90(d,J＝8.4Hz,2H),7.50(d,J＝8.4Hz,2H),5.16(d,J＝14.4Hz,1H),4.92–4.84(m,1H),3.57(s,3H),2.49(s,3H). 19 F NMR(376MHz,CDCl 3 )δ-72.74(dd,J＝11.2,4.4Hz,1F),-77.43(d,J＝11.3Hz,1F),-78.49(s,3F). 13 C NMR(101MHz,CDCl 3 )δ156.3(dd,J＝300.6,292.5Hz),147.2,132.0,131.2,120.5(q,J＝319.8Hz),117.4,68.8(dd,J＝35.7,29.8Hz),49.3,26.3,21.7.MS(ESI):m/z(％)138,153,245,293(100),([M-OTf] + ).HRMS(ESI)m/z:([M-OTf] + )Calculated for C 11 H 12 BrF 2 S:292.9806；Found:292.9798.
Example 23
Figure BDA0003821643370000293
NaH (0.9g, 60%,22.5 mmol) is added into a 1000mL reaction bottle under anhydrous and oxygen-free ice-water bath, then washing is carried out for three times (60 mL each time) by using n-pentane to remove kerosene in sodium hydrogen, the obtained active sodium hydrogen is suspended in 500mL of ultra-dry 1,4 dioxane, then thiophenol (2.48g, 20.0 mmol) is slowly dropped under the ice-water bath, and after the dropping is finished, the stirring reaction is carried out for 60 minutes at room temperature. Then cooling in ice-water bath again, slowly adding chlorotrifluoropropene (gas, excessive), naturally raising the temperature to 25 ℃ after the dropwise addition, and stirring for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 2.9 g of product, and 63% is separated. 1 H NMR(400MHz,CDCl3)δ7.34(d,J＝7.6Hz,2H),7.11(d,J＝7.6Hz,2H),3.65–3.58(m,2H),2.32(s,3H). 19 F NMR(376MHz,CDCl3)δ-87.12(d,J＝38.2Hz,1F),-92.61(d,J＝38.3Hz,1F). 13 C NMR(101MHz,CDCl3)δ155.7(dd,J＝289.5Hz,288.3Hz),138.3,133.2,129.8,129.5,90.1(dd,J＝41.1,19.2Hz),36.4(d,J＝2.2Hz),21.1.
Example 24
Figure BDA0003821643370000301
Thioether (1.18g, 5.0mmol) was added to a 100mL three-necked flask in the absence of water and oxygen, and ultra-dry DCM (10 mL) was added, followed by MeOTf (0.72g, 4.3mmol) and reacted at room temperature for 4h. And (3) spin-drying, adding methanol for dissolving, washing (layering) by using n-hexane until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and recrystallizing by using diethyl ether to obtain 1.9g of white solid with the yield of 92%. 1 H NMR(400MHz,Chloroform-d) 1 H NMR(400MHz,CDCl3)δ7.90(d,J＝7.8Hz,2H),7.49(d,J＝7.8Hz,2H),5.03(d,J＝14.0Hz,1H),4.90–4.78(m,1H),3.56(s,3H),2.49(s,3H). 19 F NMR(376MHz,CDCl3)δ-77.60(d,J＝14.2Hz),-78.62(s,3F),-82.73(d,J＝13.5Hz). 13 C NMR(101MHz,CDCl3)δ156.7(t,J＝296.7Hz),147.1,132.0,131.1,120.6(q,J＝320.1Hz),117.6,83.0(dd,J＝40.1,26.3Hz),48.1,26.4,21.7.
Example 25
Figure BDA0003821643370000302
NaH (9.0g, 60%,225 mmol) was added to a 1000mL reaction flask under an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 500mL of ultra-dry 1,4 dioxane, then mercaptan (24.9g, 180.0 mmol) was slowly dropped under an ice-water bath, and after the dropping was completed, the reaction was stirred at room temperature for 60 minutes. Then, the mixture was cooled again in an ice-water bath, bromotrifluoropropene (360mmol, 63g) was slowly added thereto, and after the dropwise addition, the mixture was naturally raised to 25 ℃ and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 43.1g of product, and the isolated yield is 82%. 1 H NMR(400MHz,CDCl 3 )δ7.32–7.26(m,2H),7.24–7.17(m,3H),3.44(dd,J＝2.8,2.0Hz,2H),2.92–2.85(m,2H),2.78–2.72(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-81.70(dt,J＝37.6,2.6Hz,1F),-87.64(dt,J＝37.6,2.6Hz,1F). 13 C NMR(101MHz,CDCl3)δ153.9(dd,J＝290.3,287.7Hz),140.0,128.5,128.4,126.5,78.9(dd,J＝37.1,21.0Hz),35.8,33.1,32.8.MS(FI):m/z(％)186,294(100)([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 11 H 11 F 2 SBr:291.9727；Found:291.9721.
Example 26
Figure BDA0003821643370000311
Thioether (50.4 mmol, 14.77g) was added to a 100mL round-bottomed flask in the absence of water and oxygen, ultra-dry diethyl ether (30 mL) was added, followed by MeOTf (8.6 mL,75.6 mmol) and allowed to react at room temperature for 12h. Filtration gave 21.52g of a white solid, with a yield of 93.4%.1H NMR (400mhz, chloroform-d) δ 7.33 (dt, J =24.0,7.3Hz, 5H), 4.64 (d, J =14.4Hz, 1h), 4.29 (d, J =12.5Hz, 1h), 3.89 (t, J =7.3Hz, 2h), 3.19 (t, J =7.2hz, 2h), 2.90 (S, 3H). 19F NMR (376 mhz, chloroform-d) δ -71.62 (d, J =12.3 Hz), -76.39 (d, J =12.5 Hz), -78.54.13c NMR (101mhz, chloroform-d) δ 156.14 (dd, J =299.8,293.0 Hz), 135.72,129.40,128.74,128.04,120.52 (q, J =319.7 Hz), 68.50 (dd, J =35.9, 29.1hz), 44.23 (d, J =2.1 Hz), 43.58,30.83,22.54.Ms (EI): M/z (%) 153.1 (100), 215.1 (M +). HRMS: sized for C10H13F2S:306.9962; found 306.9964.
Example 27
Figure BDA0003821643370000312
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then the mixture was cooled again in an ice-water bath, 2-methyl-bromodifluoropropene (25mmol, 4.28g) was slowly added thereto, and after the dropwise addition, the temperature was naturally raised to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 3.77g of product, and the separation yield is 88%.
Example 28
Figure BDA0003821643370000313
Thioether (12.2 mmol, 2.62g) was added to a 50mL round-bottomed flask in the absence of water and oxygen, super-dried DCM (10 mL) was added, followed by MeOTF (1.2 mL,11.2 mmol), and the reaction was allowed to proceed at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 3.90g of viscous liquid with a yield of 92%.
Example 29
Figure BDA0003821643370000314
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then the mixture was cooled again in an ice-water bath, and 2-phenyl-bromodifluoropropene (25mmol, 5.83g) was slowly added thereto, and after the dropwise addition, the temperature was naturally raised to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, extracting with EA, drying, and concentrating. PE column chromatography is carried out to obtain 4.97g of product, and the separation yield is 90%.
Example 30
Figure BDA0003821643370000321
Thioether (12.2mmol, 3.37g) was added to a 50mL round bottom flask in the absence of water and oxygen, followed by ultra-dry DCM (10 mL) and MeOTf (1.2mL, 11.2mmol) and allowed to react at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 4.44g of viscous liquid with the yield of 90%.
Example 31
Figure BDA0003821643370000322
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then the mixture was cooled again in an ice-water bath, 2-phenethyl-bromodifluoropropene (25mmol, 6.53g) was slowly added thereto, and after the dropwise addition, the temperature was naturally raised to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out, thus obtaining 5.60g of product with the separation yield of 92%.
Example 32
Figure BDA0003821643370000323
Thioether (12.2mmol, 3.72g) was added to a 50mL round bottom flask in the absence of water and oxygen, and ultra-dry DCM (10 mL) was added followed by MeOTf (1.2mL, 11.2mmol) and reacted at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 4.62g of viscous liquid with the yield of 88%.
Example 33
Figure BDA0003821643370000331
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then the mixture is cooled again in ice-water bath, 2-methyl p-formate phenyl-bromodifluoropropene (25mmol, 7.28g) is slowly added, and after the dropwise addition is finished, the temperature is naturally raised to the room temperature and the mixture is stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 6.29g of product, and the separation yield is 94%.
Example 34
Figure BDA0003821643370000332
Thioether (12.2 mmol, 4.08g) was added to a 50mL round-bottomed flask in the absence of water and oxygen, super-dried DCM (10 mL) was added, followed by MeOTF (1.2 mL,11.2 mmol), and the reaction was allowed to proceed at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is very weak, spin-drying the methanol, and pumping to obtain 4.86g of viscous liquid with the yield of 87%.
Example 35
Figure BDA0003821643370000333
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask under anhydrous and anaerobic ice-water bath, and then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, and the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly dropped under ice-water bath, and after the dropping, the reaction was stirred at room temperature for 30 minutes. Then the mixture was cooled again in an ice-water bath, and 2-p-ethynylphenyl-bromodifluoropropene (25mmol, 6.43g) was slowly added thereto, and after the dropwise addition, the temperature was naturally raised to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 4.21g of product, and the separation yield is 70%.
Example 36
Figure BDA0003821643370000334
Thioether (12.2mmol, 3.67g) was added to a 50mL round bottom flask in the absence of water and oxygen, followed by ultra-dry DCM (10 mL) and MeOTf (1.2mL, 11.2mmol) and allowed to react at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 4.37g of viscous liquid with a yield of 84%.
Example 37
Figure BDA0003821643370000341
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then the mixture is cooled again in an ice-water bath, 2-para-azidobenzyl-bromodifluoropropene (25mmol, 7.20g) is slowly added, and after the dropwise addition is finished, the temperature is naturally raised to the room temperature and the mixture is stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 5.17g of product, and the separation yield is 78%.
Example 38
Figure BDA0003821643370000342
Thioether (12.2mmol, 4.04g) was added to a 50mL round bottom flask in the absence of water and oxygen, and ultra dry DCM (10 mL) was added followed by MeOTf (1.2mL, 11.2mmol) and reacted at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is very weak, spin-drying the methanol, and pumping to obtain 4.72g of viscous liquid with the yield of 85%.
Example 39
Figure BDA0003821643370000343
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then cooled again in an ice-water bath, 2-butynyl-bromodifluoropropene (25mmol, 5.23g) was slowly added, and after the addition was complete, the temperature was naturally raised to room temperature and stirring was carried out for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 4.44g of product, and the isolated yield is 88%.
Example 40
Figure BDA0003821643370000351
Thioether (12.2mmol, 3.08g) was added to a 50mL round bottom flask in the absence of water and oxygen, followed by ultra dry DCM (10 mL) and MeOTf (1.2mL, 11.2mmol) and allowed to react at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 3.69g of viscous liquid with a yield of 79%.
EXAMPLE 41
Figure BDA0003821643370000352
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask under anhydrous and anaerobic ice-water bath, and then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, and the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly dropped under ice-water bath, and after the dropping, the reaction was stirred at room temperature for 30 minutes. Then the mixture was cooled again in an ice-water bath, bromobutabutene (25mmol, 4.28g) was slowly added, and after the addition was complete, the temperature was naturally raised to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 3.40g of product, and the separation yield is 80%.
Example 42
Figure BDA0003821643370000353
Thioether (12.2mmol, 2.62g) was added to a 50mL round bottom flask in the absence of water and oxygen, and ultra dry DCM (10 mL) was added followed by MeOTf (1.2mL, 11.2mmol) and allowed to react at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 3.74g of viscous liquid with the yield of 88%. 1 H NMR(400MHz,CDCl 3 )δ7.83(d,J＝8.0Hz,2H),7.46(d,J＝8.0Hz,2H),4.56(d,J＝12.8Hz,1H),4.52–4.44(m,1H),3.44(s,3H),2.47(s,3H),1.69(t,J＝3.2Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-78.52(s,3F),-84.44–-84.71(m,1F),-85.24–-85.44(m,1F).
Example 43
Figure BDA0003821643370000354
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then the mixture was cooled again in an ice-water bath, bromodifluoropropene (25mmol, 5.23g) was slowly added thereto, and after the dropwise addition, the mixture was naturally warmed to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 3.89g of product, and the separation yield is 77%.
Example 44
Figure BDA0003821643370000361
Thioether (12.2 mmol, 3.09g) was added to a 50mL round-bottomed flask in the absence of water and oxygen, super-dried DCM (10 mL) was added, followed by MeOTF (1.2 mL,11.2 mmol), and the reaction was allowed to proceed at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 4.10g of viscous liquid with the yield of 88%.
Example 45
Figure BDA0003821643370000362
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then, the mixture was cooled again in an ice-water bath, and methyl bromodifluoroacrylate (25mmol, 5.38g) was slowly added thereto, and after completion of the dropwise addition, the mixture was naturally raised to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out, thus obtaining 4.49g of product with the isolated yield of 87%.
Practice of example 46
Figure BDA0003821643370000363
Thioether (12.2mmol, 3.15g) was added to a 50mL round bottom flask in the absence of water and oxygen, super-dried DCM (10 mL) was added, and then MeOTf (1.2mL, 11.2mmol) was added and the reaction was allowed to proceed at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is very weak, spin-drying the methanol, and pumping to obtain 3.74g of viscous liquid with the yield of 79%.
Example 47
Figure BDA0003821643370000364
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then the mixture was cooled again in an ice-water bath, bromodifluorobutenol benzyl ether (25mmol, 6.93g) was slowly added thereto, and after completion of the dropwise addition, the mixture was naturally warmed to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, extracting with EA, drying, and concentrating. PE column chromatography is carried out to obtain 5.64g of product, and the separation yield is 88%.
Example 48
Figure BDA0003821643370000371
Thioether (12.2mmol, 3.91g) was added to a 50mL round bottom flask in the absence of water and oxygen, followed by ultra-dry DCM (10 mL) and MeOTf (1.2mL, 11.2mmol) and allowed to react at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 4.29g of viscous liquid with a yield of 79%.
Example 49
Figure BDA0003821643370000372
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then, the mixture was cooled again in an ice-water bath, bromodifluoropropene (25mmol, 7.20g) was slowly added thereto, and after the dropwise addition, the temperature was naturally raised to room temperature and the mixture was stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 5.64g of product, and the separation yield is 85%.
Example 50
Figure BDA0003821643370000373
Thioether (12.2mmol, 4.05g) was added to a 50mL round-bottomed flask in the absence of water and oxygen, super-dried DCM (10 mL) was added, followed by MeOTF (1.2mL, 11.2mmol) and allowed to react at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is extremely weak, spin-drying the methanol, and suction-drying to obtain 4.22g of viscous liquid with the yield of 76%.
Example 51
Figure BDA0003821643370000374
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask in an anhydrous oxygen-free ice-water bath, then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly added dropwise in the ice-water bath, and after the addition was completed, the reaction was stirred at room temperature for 30 minutes. Then, the mixture was cooled again in an ice-water bath, bromodifluoropropene (25mmol, 4.88g) was slowly added thereto, and after the dropwise addition, the mixture was naturally warmed to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 4.24g of product, and the separation yield is 89%.
Example 52
Figure BDA0003821643370000381
Thioether (12.2 mmol, 2.91g) was added to a 50mL round-bottomed flask in the absence of water and oxygen, super-dried DCM (10 mL) was added, followed by MeOTF (1.2 mL,11.2 mmol), and the reaction was allowed to proceed at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of the n-hexane layer is very weak, spin-drying the methanol, and pumping to obtain 3.52g of viscous liquid with a yield of 78%.
Example 53
Figure BDA0003821643370000382
Weighing Pd (PPh) into a reaction vessel 3 ) 2 Cl 2 (0.05 equiv) and t-BuDavePhos (0.1 equiv), argonPrepared zinc reagent (1.5 equiv, tetrahydrofuran solution) and thioether (1.0 equiv) starting materials were added under protective conditions, and finally MeCN (MeCN: THF =1, meCN to zinc reagent molar ratio 0.5 mol/L) was added and reacted at room temperature for 12 hours. Wherein, the preparation of the zinc reagent can adopt the conventional preparation method in the field, and also can adopt the method provided by the invention, and if no special description is made, the following compounds are prepared according to the preparation scheme.
The product is as follows:
Figure BDA0003821643370000383
104mg of colorless liquid, yield 36 percent and PE column chromatography. 1 H NMR(400MHz,CDCl 3 )δ7.43–7.34(m,4H),7.32–7.24(m,3H),7.24–7.18(m,1H),7.18–7.12(m,2H),3.56–3.51(m,2H),2.94–2.83(m,2H),2.81–2.66(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-88.76(d,J＝37.1Hz,1F),-88.96(d,J＝37.0Hz,1F). 13 C NMR(101MHz,CDCl 3 )δ154.4(dd,J＝293.3,289.7Hz),140.3,132.4(t,J＝3.1Hz),128.5,128.4,128.3(t,J＝3.2Hz),127.8,126.4,90.5(dd,J＝19.4,14.8Hz),36.0,33.0,29.9(d,J＝2.8Hz).
The product is as follows:
Figure BDA0003821643370000384
0.9g, yellow liquid, yield 28%. 1 H NMR(400MHz,CDCl 3 )δ7.33–7.25(m,4H),7.24–7.19(m,1H),7.18–7.14(m,2H),6.93–6.87(m,2H),3.80(s,3H),3.51(t,J＝2.2Hz,2H),2.91–2.82(m,2H),2.76–2.68(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-89.66(d,J＝39.7Hz,1F),-89.97(d,J＝39.6Hz,1F). 13 C NMR(101MHz,CDCl 3 )δ159.0,155.7(dd,J＝292.3Hz,J＝292.5Hz),140.3,133.1,129.5(t,J＝3.2Hz),128.5,126.3,124.5(t,J＝3.4Hz),113.9,89.9(dd,J＝19.8,15.0Hz),55.2,36.0,33.0,30.0(d,J＝2.7Hz).
The product is as follows:
Figure BDA0003821643370000391
78mg, colorless liquid, yield 28%, silica gel column chromatography (petroleum ether/ethyl acetate = 100. 1 H NMR(400MHz,CDCl 3 )δ 1 H NMR(400MHz,CDCl 3 )δ7.39(d,J＝8.0Hz,2H),7.35–7.24(m,4H),7.21(dd,J＝8.6,6.8Hz,1H),7.17–7.10(m,2H),3.55(s,2H),2.86(dd,J＝9.7,6.2Hz,2H),2.73(dd,J＝9.7,6.1Hz,2H),1.32(s,9H). 19 F NMR(376MHz,CDCl 3 )δ-88.68(d,J＝37.9Hz),-88.81(d,J＝37.8Hz). 19 F NMR(376MHz,CDCl 3 )δ-88.89(d,J＝37.5Hz,1F),-89.02(d,J＝37.9Hz,1F). 13 C NMR(101MHz,CDCl 3 )δ154.4(dd,J＝292.7,290.2Hz),150.6,140.3,129.3,128.4,127.9(t,J＝3.1Hz),126.3,125.4,90.3(dd,J＝18.7,15.3Hz),36.1,34.5,33.0,31.2,29.7.
The product is as follows:
Figure BDA0003821643370000392
79mg, colorless oily liquid, yield 22%, silica gel column chromatography (petroleum ether/ethyl acetate = 80. 1 H NMR(400MHz,CDCl 3 )δ8.04(d,J＝8.0Hz,2H),7.46(d,J＝8.0Hz,2H),7.35–7.18(m,3H),7.16(d,J＝7.2Hz,2H),4.38(q,J＝7.2Hz,2H),3.5(s,2H),2.97–2.83(m,2H),2.79–2.64(m,2H),1.39(t,J＝7.2Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-86.48(d,J＝32.6Hz,1F),-86.61(d,J＝32.6Hz,1F). 13 C NMR(101MHz,CDCl 3 )δ166.1,154.6(dd,J＝295.0,291.3Hz),140.1,137.0(d,J＝2.7Hz),129.7,129.6,128.5,128.4,128.2(t,J＝3.1Hz),126.4,90.3(dd,J＝19.8,14.4Hz),61.0,35.9,33.1,29.5,14.3.MS(FI):m/z(％)362(100).([M] + )；HRMS(FI)m/z:([M] + )Calculated for C 20 H 20 F 2 O 2 S:362.1147；Found:362.1151.
Figure BDA0003821643370000393
Under the anhydrous and oxygen-free conditions (Ar), the raw material A is placed in LiAlH 4 Quenching after reducing ester group, and extracting with conventional organic solventAfter work-up 1.2 equivalents of DPPA and 1.2 equivalents of DBU were added to give the product 656mg, colorless oily liquid in 38% yield, isolated by silica gel column chromatography (petroleum ether/ethyl acetate = 80. 19 F NMR(376MHz,CDCl 3 )δ-88.1(d,J＝35.7Hz,1F),-88.2(d,J＝43.6Hz,1F). 1 H NMR(400MHz,CDCl 3 )δ7.40(d,J＝8.4Hz,2H),7.32-7.28(m,4H),7.24-7.21(m,1H),7.20-7.15(m,2H),4.35(s,2H),3.54(t,J＝2.0Hz,2H),2.89–2.85(m,2H),2.76–2.72(m,2H).
The product is as follows:
Figure BDA0003821643370000401
1.1g, yellow liquid, yield 34%. 1 H NMR(400MHz,Chloroform-d)δ7.42–7.10(m,6H),6.96(d,J＝9.5Hz,2H),6.85(d,J＝8.5Hz,1H),3.80(s,3H),3.53(s,2H),2.87(t,J＝7.8Hz,2H),2.74(dd,J＝9.3,6.4Hz,2H). 19 F NMR(376MHz,Acetonitrile-d3)δ-93.35(d,J＝36.5Hz,1F),-93.91(d,J＝36.5Hz,1F). 13 C NMR(101MHz,Chloroform-d)δ159.55,158.05–150.55(m),140.32,133.78(t,J＝4.0Hz),129.46,128.47,128.44,126.36,120.71(t,J＝3.2Hz),114.35(t,J＝3.6Hz),113.08,90.50(dd,J＝20.0,13.7Hz),55.21,36.03,33.09,29.92,29.89。
The product is as follows:
Figure BDA0003821643370000402
0.88g, pale yellow liquid, yield 46%. 1 H NMR(400MHz,Chloroform-d)δ7.48(d,J＝7.7Hz,2H),7.32(dd,J＝12.0,7.5Hz,4H),7.24(d,J＝14.6Hz,1H),7.24(s,1H),7.18(d,J＝7.1Hz,2H),3.53(s,2H),2.96–2.80(m,2H),2.80–2.59(m,2H),0.27(s,9H). 19 F NMR(376MHz,Chloroform-d)δ-87.39(d,J＝34.3Hz),-87.60(d,J＝34.4Hz). 13 C NMR(126MHz,Chloroform-d)δ158.18–150.25(m),140.21,132.54,132.01,131.80,131.48,128.49,128.46,128.06(t,J＝3.4Hz),126.41,122.52,104.61,95.01,92.11–88.53(m),35.97,33.10,29.54,-0.08。
Example 54 preparation of 3, 3-Difluoroallyl onium salt
Figure BDA0003821643370000403
A solution of thioether in methylene chloride (1.05equiv, 0.5M CH) was obtained in example 53 under anhydrous and oxygen-free conditions at 0 deg.C 2 Cl 2 Solution) was slowly added dropwise to methyl trifluoromethanesulfonate (1.0 equiv) and stirred at room temperature overnight. After the reaction is finished, ether is dripped into the system, and the product can be separated out. The following sulfur salts were prepared in this manner, unless otherwise specified.
The product is as follows:
Figure BDA0003821643370000404
1.8g, white solid, yield 79%. m.p.48.7-51.5 ℃. 1 H NMR(400MHz,CDCl 3 )δ7.47–7.33(m,3H),7.35–7.23(m,5H),7.17(d,J＝6.8Hz,2H),4.61(d,J＝14.0Hz,1H),4.40(d,J＝14.0Hz,1H),3.74(t,J＝7.2Hz,2H),3.49(s,3H),3.16–3.00(m,2H),2.73(s,3H). 19 F NMR(376MHz,CDCl 3 )δ-78.39(s,3F),-79.54(d,J＝15.2Hz,1F),-79.77(d,J＝15.2Hz,1F). 13 C NMR(126MHz,CDCl 3 )δ156.0(t,J＝299.2Hz),135.7,129.4,129.2,129.1,128.8(t,J＝2.6Hz),128.6,128.2(t,J＝2.5Hz),127.9,120.4(q,J＝319.6Hz),84.4(dd,J＝21.3,18.4Hz),43.4,41.1(d,J＝4.3Hz),30.7,22.5.MS(ESI):m/z(％)105,305(100).([M-OTf] + )；HRMS(ESI)m/z:([M-OTf] + )Calculated for C 18 H 19 F 2 S:305.1170；Found:305.1162.
The product is as follows:
Figure BDA0003821643370000411
730mg, viscous liquid, 73% yield. 1 H NMR(400MHz,CDCl 3 )δ7.37–7.21(m,5H),7.18(d,J＝7.3Hz,2H),6.92(d,J＝8.3Hz,2H),4.56(d,J＝13.9Hz,1H),4.38(d,J＝13.8Hz,1H),3.80(s,3H),3.71(t,J＝7.4Hz,2H),3.16–2.95(m,2H),2.73(s,3H). 19 F NMR(400MHz,CDCl 3 )δ-78.41(s,3F),-81.16(d,J＝19.0Hz,1F),-81.30(d,J＝19.0Hz,1F). 13 C NMR(101MHz,CDCl 3 )δ159.9,155.6(t,J＝297.1Hz),135.7,129.4,129.0,128.5,127.6,120.53(q,J＝320.5Hz),120.49,114.6,83.8(t,J＝19.8Hz),55.1,43.0,41.1,30.3,22.2.MS(ESI):m/z(％)145.1,335.1(100),([M-OTf] + ).HRMS(ESI)m/z:([M-OTf] + )Calculated for C 19 H 21 OF 2 S:335.1276；Found:335.1276.
The product is as follows:
Figure BDA0003821643370000412
370mg of a white solid, 43% yield. m.p.86.3-87.4oC;1H NMR (400MHz, CDCl3) delta 7.43 (d, J =7.6Hz, 2H), 7.34-7.22 (M, 5H), 7.16 (d, J =6.8Hz, 2H), 4.61 (d, J =13.8Hz, 1H), 4.42 (d, J =13.8Hz, 1H), 3.73 (t, J =7.2Hz, 2H), 3.20-2.95 (M, 2H), 2.76 (S, 3H), 1.31 (S, 9H). 19F NMR (400MHz, CDCl3) delta-83.65 (S, 3F), -85.20 (d, J =16.4Hz, 1f), -85.49 (d, J =16.4Hz, 1f). 13C NMR (126mhz, cdcl3) δ 156.0 (dd, J =299.1,297.7 Hz), 152.6,135.7,129.2,128.6,127.84,127.77 (t, J =2.5 Hz), 126.4,120.5 (q, J =319.7 Hz), 84.2 (dd, J =21.3, 18.2hz), 43.3,41.0 (d, J =3.8 Hz), 34.7,31.1,30.7,22.5.Ms (ESI): M/z (%) 215.1,361.2 (100), ([ M-OTf ] +). HRMS (ESI) M/z, ([ M-OTf ] +) sized for C22H27F2S:361.1796; found 361.1799.
The product is as follows:
Figure BDA0003821643370000413
840mg, white solid, 84% yield. m.p.104.8-105.6 ℃; 1 H NMR(400MHz,CDCl 3 )δ8.08(d,J＝7.6Hz,2H),7.44(d,J＝7.6Hz,2H),7.36–7.23(m,3H),7.19(d,J＝6.4Hz,2H),4.72(d,J＝14.0Hz,1H),4.48(d,J＝14.0Hz,1H),4.39(q,J＝6.8Hz,2H),3.81(t,J＝6.8Hz,2H),3.15–3.00(m,2H),2.74(s,3H),1.40(t,J＝7.0Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-77.38(d,J＝10.8Hz,1F),-77.70(d,J＝10.8Hz,1F),-78.48(s,3F). 13 C NMR(126MHz,CDCl 3 )δ165.7,156.3(dd,J＝300.5,299.6Hz),135.7,133.3(t,J＝3.2Hz),131.1,130.4,129.3,128.6,128.3(t,J＝3.2Hz),128.0,84.3(t,J＝19.7Hz),61.4,43.6,40.8,30.8,22.6,14.3.MS(ESI):m/z(％)356,377(100)([M-OTf] + ).HRMS(ESI)m/z:([M-OTf] + )Calculated for C 21 H 23 F 2 O 2 S:377.1381；Found:377.1380.
the product is as follows:
Figure BDA0003821643370000421
880mg, white solid, 91% yield. 19 F NMR(376MHz,CDCl 3 )δ-78.5(s,3F),-78.9(d,J＝16.1Hz,1F),-79.2(d,J＝15.0Hz,1F). 1 H NMR(400MHz,CDCl 3 )δ7.37(s,3H),7.34-7.25(m,4H),7.19-7.16(m,2H),4.65(d,J＝13.2Hz,1H),4.44(d,J＝14.4Hz,1H),4.36(s,2H),3.76(t,J＝7.6Hz,2H),3.15–3.05(m,2H),2.74(s,3H).
The product is as follows:
Figure BDA0003821643370000422
660mg, viscous liquid, 68%. 1 H NMR(400MHz,Chloroform-d)δ7.38–7.13(m,6H),6.98–6.85(m,3H),4.61(d,J＝14.0Hz,1H),4.40(d,J＝14.1Hz,1H),3.83(s,3H),3.74(t,J＝7.3Hz,2H),3.09(q,J＝6.8Hz,2H),2.74(s,3H). 19 F NMR(376MHz,Chloroform-d)δ-78.38(s,3F),-79.22(d,J＝14.7Hz,1F),-79.42(d,J＝14.6Hz,1F). 13 C NMR(126MHz,Chloroform-d)δ160.26,158.87–153.36(m),135.73,130.57,130.19(t,J＝2.6Hz),129.34,128.66,127.94,120.43,115.25,113.65(t,J＝2.9Hz),84.49(dd,J＝21.5,18.2Hz),55.50,43.48,41.16(d,J＝4.4Hz),30.79,22.56.
The product is as follows:
Figure BDA0003821643370000423
773mg, white solid, yield 61%. 1 H NMR(400MHz,Chloroform-d)δ7.51(d,J＝7.2Hz,2H),7.40–7.24(m,5H),7.19(d,J＝7.0Hz,2H),4.66(s,1H),4.44(s,1H),3.80(s,2H),3.11(s,2H),2.71(s,3H),0.26(s,9H). 19 F NMR(376MHz,Chloroform-d)δ-78.21(d,J＝12.6Hz),-78.49.
Example 55
Figure BDA0003821643370000431
NaH (1.20g, 60%,30 mmol) was added to a 100mL reaction flask under anhydrous and anaerobic ice-water bath, and then kerosene in sodium hydrogen was removed by washing three times (60 mL each) with n-pentane, and the obtained active sodium hydrogen was suspended in 80mL of ultra-dry dioxane, and then thiophenol (3.79g, 20.0 mmol) was slowly dropped under ice-water bath, and after the dropping, the reaction was stirred at room temperature for 30 minutes. Then, the mixture was cooled again in an ice-water bath, and 2-butenyl difluoropropene (25mmol, 5.24g) was slowly added thereto, and after the dropwise addition, the temperature was naturally raised to room temperature and stirred for 24 hours. Quenching with saturated ammonium chloride, performing EA extraction, drying, and concentrating. PE column chromatography is carried out to obtain 4.0g of product, and the separation yield is 79%.
Example 56
Figure BDA0003821643370000432
Thioether (12.2mmol, 3.10 g) was added to a 50mL round bottom flask in the absence of water and oxygen, and ultra-dry DCM (10 mL) was added, followed by MeOTf (1.2mL, 11.2mmol), and the reaction was carried out at room temperature for 12h. Spin-drying, adding methanol for dissolving, washing with n-hexane (layering) until the fluorescence of n-hexane layer is extremely weak, spin-drying methanol, and suction-drying to obtain 2.80g viscous liquid with yield of 60%. 1 H NMR(400MHz,CDCl 3 )δ7.83(d,J＝7.8Hz,2H),7.45(d,J＝7.8Hz,2H),5.76–5.59(m,1H),5.02(d,J＝17.2Hz,1H),4.98(d,J＝10.0Hz,1H),4.53(d,J＝13.2Hz,1H),4.48–4.39(m,1H),3.43(s,3H),2.45(s,3H),2.31–2.00(m,4H). 19 F NMR(376MHz,CDCl 3 )δ-78.30(s,3F),-82.92(d,J＝25.1Hz,1F),-83.73(d,J＝25.1Hz,1F).
Example 57
Figure BDA0003821643370000433
To a solution of potassium carbonate (2.0 equiv.) in methanol under an argon atmosphere, the product of the previous step and phenethyl mercaptan (1.0 equiv.) were added and stirred at room temperature overnight. The reaction system is filtered, dried by spinning and subjected to column chromatography to obtain a target compound, and the following compounds are prepared by the method.
And (3) a product:
Figure BDA0003821643370000434
4.6g, yellow liquid, 52%. 19 F NMR(376MHz,CDCl 3 )δ-87.53(d,J＝44.3Hz),-89.74(dd,J＝44.1,24.3Hz). 1 H NMR(400MHz,CDCl 3 )δ7.38–7.26(m,4H),7.25–7.14(m,5H),4.15(ddd,J＝24.3,10.8,1.8Hz,1H),2.96–2.81(m,4H),2.81–2.65(m,4H),2.52(t,J＝7.2Hz,2H),1.71–1.42(m,7H).
The product is as follows:
Figure BDA0003821643370000441
466mg of yellow liquid, 13%. 19 F NMR(376MHz,CDCl 3 )δ-87.32(d,J＝43.8Hz),-89.60(dd,J＝43.8,24.2Hz). 1 H NMR(400MHz,CDCl 3 )δ7.31(t,J＝7.1Hz,2H),7.26–7.10(m,3H),4.16(dd,J＝24.7,11.4Hz,1H),3.68–3.42(m,1H),3.27(t,J＝6.6Hz,2H),2.94–2.80(m,2H),2.79–2.62(m,2H),1.75–1.37(m,6H).
The product is as follows:
Figure BDA0003821643370000442
4.5g, yellow liquid, 58%. 19 F NMR(376MHz,CDCl 3 )δ-87.84(d,J＝44.8Hz),-90.08(dd,J＝44.7,24.4Hz). 1 H NMR(400MHz,CDCl 3 )δ7.30(t,J＝7.5Hz,2H),7.21(dd,J＝14.6,7.2Hz,3H),4.23–4.05(m,1H),3.67(s,3H),3.55–3.41(m,1H),2.98–2.80(m,2H),2.79–2.63(m,2H),2.30(t,J＝7.5Hz,2H),1.70–1.19(m,14H).
Example 58
Figure BDA0003821643370000443
Three ports of 250mLThe flask was charged (5.53g, 40mmol,2.0 equiv), difluoroallyl compound (20mmol, 1.0 equiv) and methanol (MeOH, 60 mL) were added, thiol (20mmol, 1.0 equiv) was added dropwise, stirring was performed at room temperature overnight, filtration was performed, washing was performed with ethyl acetate three times, washing was performed with brine, drying was performed with anhydrous sodium sulfate, drying was performed, concentration was performed, and purification was performed by petroleum ether column chromatography to obtain a colorless oily product (3.46g, 72% yield). 1 H NMR(400MHz,CDCl 3 )δ7.31(t,J＝7.2Hz,2H),7.25–7.17(m,3H),4.15(ddd,J＝24.4,10.9,2.0Hz,1H),3.54–3.42(m,1H),3.01–2.59(m,4H),1.77–1.58(m,1H),1.55–1.43(m,1H),1.41–1.33(m,2H),1.32–1.24(m,6H),0.89(t,J＝6.8Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-87.90(dd,J＝45.0,2.0Hz),-90.12(dd,J＝45.0,24.5Hz). 13 C NMR(101MHz,CDCl 3 )δ157.3(t,J＝288.9Hz),140.4,128.4,126.3,82.0(t,J＝19.6Hz),38.8,38.7,36.2,35.1,32.3,31.6,28.8,27.1,22.5,14.0.MS(FI):m/z(％)298(100)([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 17 H 24 F 2 S:298.1561；Found:298.1567.
Figure BDA0003821643370000444
Thioether (1.4 g,4.7mmol, 1.05equiv) was added to a 100mL Schlenk tube under anhydrous and oxygen-free conditions, ultra-dry DCM (10 mL) was added, meOTF ((4.5 mmol,1.0 equiv) was added to an ice-water bath, and the reaction was stirred at room temperature overnight. 1 H NMR(400MHz,CD 2 Cl 2 ) Mixture of diastereomers: δ 7.35-7.19 (m, 5H), 4.51-4.35 (m, 1H), 4.34-4.23 (m, 0.45H), 4.18-4.07 (m, 0.55H), 3.49-3.37 (m, 2H), 3.18-3.02 (m, 2H), 2.77 (s, 1.7H) (2.74 (s, 1.3H)), 1.85-1.61 (m, 2H), 1.32-1.15 (m, 8H), 0.81 (t, J =6.6hz, 3h). 19 F NMR(376MHz,CD 2 Cl 2 ) Diastereomer mixtures delta-75.34 (d, J =16.6Hz, 0.56F), -75.52 (d, J =15.8Hz, 0.44F), -77.14-77.34 (M, 1F), -78.96 (s, 3F) MS (ESI) M/z (%) 153,167,181,313 (100) ([ M-OTf) ("M-OTf] + ).HRMS(ESI)m/z:([M-OTf] + )Calculated for C 18 H 27 F 2 S:313.1796；Found:313.1794.
The following examples are 3,3-difluoroallylsulfonium salts, selenonium salts, tellurium salts and their derivatives used in synthetic chemistry.
Application examples preliminary experiments:
optimization of reaction solvent
Figure BDA0003821643370000451
Under anhydrous and oxygen-free conditions, magnetons, sulfur salt (72.9mg, 0.2mmol) and CuBr (2.8mg, 0.02mmol) are added into a reaction tube, gas is pumped for three times, 2mL of ultra-dry and anhydrous solvent described in the following table is added under Ar, then the mixture is stirred uniformly, zinc reagent SM2 (0.464M) is slowly dropped at room temperature, and after the dropping is finished, the mixture is stirred at room temperature for reaction for 3 hours. The results of the reaction are shown in the following table:
Figure BDA0003821643370000452
note: weighing the catalyst in air; the target compound represents a target compound; SM1 represents the starting material(s), 19 f% refers to fluorobenzene as internal standard substance 19 FNMR determination yield; ND means not detected.
The temperature of the coupling reaction in this step is not particularly limited and may be in the range of-78 to 35 ℃.
Optimizing the dosage of zinc reagent [ C ] - [ Zn ]:
Figure BDA0003821643370000453
experimental procedures see the optimization experiment of the reaction solvent, and the conditions of the zinc reagent are as follows:
examples [Ar-ZnCl-LiCl] Target compound (A) 19 F％) SM1( 19 F％)
1 1.1equiv >99 ND
2 1.2equiv 95 ND
3 1.3equiv 94 ND
4 1.5equiv 96 ND
Note: ND means not detected.
Optimizing the type of the catalyst:
Figure BDA0003821643370000461
and (3) experimental operation: 1a (0.2mmol, 1.0 equiv), 4a (1.2 equiv), THF (2 mL), see optimization of reaction solvents for the procedure, catalyst types as shown in the following table:
Figure BDA0003821643370000462
note: 19 f% refers to fluorobenzene as internal standard substance 19 F NMR determination yield; ND means not detected. c CuCl (99.999%) was used.
The following experiment was optimized with CuBr as the catalyst, considering that CuBr is low in cost and easy to operate.
Optimizing the dosage of the catalyst:
Figure BDA0003821643370000463
the catalyst amounts are given in the following table:
Figure BDA0003821643370000464
note: trace represents a trace amount.
Comparative examples 1 to 6:
unless otherwise stated, the operating conditions were as described in the above-mentioned optimized experimental examples, and the comparative conditions are as follows:
Figure BDA0003821643370000471
preparation example of zinc reagent:
general procedure for arylzinc reagents:
1) Grignard reagent conversion:
Figure BDA0003821643370000472
weighing magnesium chips in a 50ml Shi Laike bottle, weighing lithium chloride in a glove box, baking the lithium chloride by a baking gun in a pumping state until the lithium chloride does not hang on the wall, naturally recovering the room temperature, adding THF, placing the THF in an ice-water bath, adding DIBAL-H, stirring until no bubble is generated in the reaction, then quickly adding an aryl bromide raw material, stirring for 10min in the ice-water bath, recovering the room temperature, stirring for reacting for 4H, and titrating the concentration. Filtering by a filter head, quantitatively adding a zinc chloride solution, stirring and reacting for 1h, and titrating the concentration.
Preparation examples 1 to 3
Figure BDA0003821643370000473
2) Iodine-magnesium exchange method: (Zinc reagent containing functional group)
Figure BDA0003821643370000474
Adding a magnet into a 50ml Schlenk bottle, pumping and changing gas for three times, adding a THF solution of i-Pr-MgCl-LiCl under Ar, placing at the corresponding cold bath temperature, keeping the temperature and stirring for 5min, then adding a corresponding aryl iodine reagent (adding solid in batches and dropwise adding liquid), and monitoring whether the conversion of the raw material is complete by GC. After complete conversion, the concentration of the Grignard reagent is titrated, and according to the concentration and the volume of the Grignard reagent, a zinc chloride solution is added and stirred for 20min at room temperature. The concentration was titrated again.
Preparation examples 4 to 8:
Figure BDA0003821643370000481
preparation of an alkyl zinc reagent:
and (3) zinc powder insertion:
Figure BDA0003821643370000482
preparation examples 9 to 16:
Figure BDA0003821643370000483
weighing zinc powder and lithium chloride into a sealed tube, pumping air for three times, baking for 5-10min by using a baking gun under the condition of pumping air, recovering to room temperature, adding THF (tetrahydrofuran) for stirring, then adding 1,2-dibromoethane, heating in an oil bath at 60 ℃ to bubbling, cooling to room temperature, then adding iodine and TMSCl, heating in an oil bath at 60 ℃ for stirring for reacting for 20min, then cooling to room temperature, adding the raw materials, and stirring in an oil bath at 50-80 ℃ for reacting for 18h. (C above represents the concentration of the zinc reagent product)
Application example 1
Wherein at least
Figure BDA0003821643370000484
The reaction with the zinc reagent is exemplified,
unless otherwise specified, the reaction was carried out by referring to the above examples (preliminary experiments using examples) and the zinc reagents shown in the following tables, and the reaction results are shown in the following tables.
Figure BDA0003821643370000491
Figure BDA0003821643370000501
Figure BDA0003821643370000511
Figure BDA0003821643370000521
Note: to be provided with 19 F NMR measurement yield.
Application examples
Referring to the application example section, the zinc reagents shown in the following table were reacted and the results are shown in the following table:
Figure BDA0003821643370000531
Figure BDA0003821643370000541
Figure BDA0003821643370000551
note: to be provided with 19 F NMR measurement yield.
Application example 2
Figure BDA0003821643370000552
2.5mol% of CuBr was charged into a 25mL Schlenk bottle, a difluoroallylic onium salt represented by the formula C (0.5 mmol,1.0 equiv) was added, and vacuum-charged with Ar three times. 2.0mL of THF was added and the formula [ C ] was added dropwise]-[Zn]The indicated zinc reagent (1.2 equiv) was stirred at room temperature for 3 hours to effect a reaction. Using fluorobenzene as internal standard reagent 19 F NMR determination of the product yield, NH 4 The reaction was quenched with Cl and diluted to dryness with EtOAc, the aqueous phase was washed with ethyl acetate (3X 10 mL) and the organic phase was Na 2 SO 4 Drying, filtering and collecting. And purifying the filtrate by column chromatography or preparative reverse phase HPLC to obtain the target compound.
The reaction results are shown below:
the product is as follows:
Figure BDA0003821643370000553
a yellow oily liquid, 114mg,>99％yield，α/γ>99:1 19 f NMR determination, purification with FP ECOFLEX C18 (mobile phase: meCN: H) 2 O＝7:3) 1 H NMR(400MHz,CDCl 3 )δ7.66(d,J＝8.4Hz,2H),7.63–7.57(m,4H),7.47(t,J＝7.6Hz,2H),7.39(t,J＝7.6Hz,1H),6.30–6.10(m,1H),5.63(dt,J＝17.4,2.8Hz,1H),5.52(d,J＝10.8Hz,1H). 19 F NMR(376MHz,CDCl 3 )δ-93.37(d,J＝9.5Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ142.9,140.2,135.1(t,J＝27.7Hz),133.7(t,J＝30.1Hz),128.9,127.8,127.21,127.15,126.0(t,J＝5.6Hz),119.8(t,J＝9.1Hz),119.3(t,J＝238.3Hz).MS(EI):m/z(％)152,203,230([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 15 H 12 F 2 :230.0906；Found:230.0902.
And (3) a product:
Figure BDA0003821643370000554
colorless oily liquid, 120.4mg,91% yield>99:1 19 F NMR measurement. 1 H NMR(400MHz,CDCl 3 )δ7.69-7.68(m,2H),7.64–7.61(m,4H),7.50-7.46(m,2H),7.42-7.39(m,1H),6.30–6.10(m,1H),5.90-5.89(m,1H),5.71-5.70(m,1H). 19 F NMR(376MHz,CDCl 3 )δ-95.52(s,2F). 13 C NMR(101MHz,CDCl 3 )δ143.5,140.02,136.2(t,J＝34.3Hz),132.9(t,J＝27.2Hz),128.9,127.9,127.22,127.16,126.4(t,J＝5.7Hz),117.54(t,J＝5.3Hz),117.46(t,J＝244.2Hz).
The product is as follows:
Figure BDA0003821643370000561
colorless oil, 76mg,83% yield, silica gel chromatographic separation (DCM: PE =5 1 H NMR(400MHz,CDCl 3 )δ7.34(t,J＝7.8Hz,1H),7.09(d,J＝7.8Hz,1H),7.04(s,1H),6.97(d,J＝8.0Hz,1H),6.22-6.04(m,1H),5.66–5.54(m,1H),5.48(d,J＝10.8Hz,1H),3.83(s,3H). 19 F NMR(376MHz,CDCl 3 )δ-93.64(d,J＝10.0Hz，2F). 13 C NMR(101MHz,CDCl 3 )δ159.6,137.7(t,J＝27.5Hz),133.7(t,J＝30.0Hz),129.6,119.8(t,J＝9.1Hz),119.1(t,J＝238.7Hz),117.8(t,J＝5.7Hz),115.6(t,J＝1.5Hz),111.0(t,J＝5.9Hz),55.3.MS(FI):m/z(％)91,138,184(100)([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 10 H 10 F 2 O:184.0694；Found:184.0692.
The product is as follows:
Figure BDA0003821643370000562
a colorless oil, 69mg,65% by weight>99:1 19 F NMR determination, silica gel chromatography, low boiling point, 1 H NMR(400MHz,CDCl 3 )δ7.44(s,4H),6.38–5.96(m,1H),5.60(dt,J＝17.2,2.8Hz,1H),5.47(d,J＝10.8Hz,1H),1.34(s,9H). 19 F NMR(376MHz,CDCl3)δ-93.12(dd,J＝9.6,2.7Hz,2F). 13 C NMR(126MHz,CDCl3)δ159.6,137.7(t,J＝27.5Hz),133.7(t,J＝30.0Hz),129.6,119.8(t,J＝9.1Hz),119.1(t,J＝238.7Hz),117.8(t,J＝5.7Hz),115.6(t,J＝1.5Hz),111.0(t,J＝5.9Hz),55.3.
and (3) a product:
Figure BDA0003821643370000563
slightly yellow oil, 107mg,95% yield>99:1 19 F NMR determination, silica gel chromatography purification (petroleum ether/ethyl acetate =100 1), FP ECOFLEX C18 (20 g) purification isolation (MeCN: H 2 O＝7:3)， 1 H NMR(400MHz,CDCl 3 )δ8.10(d,J＝8.8Hz,2H),7.57(d,J＝8.8Hz,2H),6.15(ddt,J＝17.2,10.8,9.6Hz,1H),5.57(dt,J＝17.2,2.8Hz,1H),5.51(d,J＝10.8,1H),4.40(q,J＝7.2Hz,2H),1.41(t,J＝7.2Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-94.43(dd,J＝9.5,2.8Hz,2F). 13 C NMR(126MHz,CDCl 3 )δ165.8,140.4(t,J＝27.7Hz),133.3(t,J＝29.7Hz),131.9,129.6,125.5(t,J＝5.7Hz),120.3(t,J＝9.2Hz),118.9(t,J＝239.0Hz),61.2,14.2.MS(EI):m/z(％)133,153,181(100),198,226([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 12 H 12 O 2 F 2 :226.0800；Found:226.0804.
The product is as follows:
Figure BDA0003821643370000564
yellow oil, (93.0 mg,62% yield) chromatographically on silica gel (petroleum ether), 1 H NMR(400MHz,CDCl 3 )δ7.57–7.53(m，2H)，7.44–7.41(m，1H)，7.42–7.32(m，1H)，6.20–6.04(m，1H)，5.60(d，J＝17.6，2.8Hz，1H)，5.55(d,J＝11.0Hz,1H). 19 F NMR(376MHz,CDCl 3 )δ-72.81(s,3F),-93.87(dd,J＝9.8,2.9Hz,2F). 13 C NMR(126MHz,CDCl 3 )δ149.4,139.0(t,J＝28.7Hz),132.8(t,J＝29.6Hz),130.6,125.6(t,J＝5.5Hz),122.9,120.8(t,J＝9.2Hz),118.9(t,J＝5.9Hz),118.7(q,J＝320.7Hz).118.1(t,J＝239.6Hz).MS(FI):m/z(％)61(100),70,88,302([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 10 H 7 O 3 F 5 s, 302.0031; found 302.0027 product:
Figure BDA0003821643370000571
micro-butter-like objects, 66mg,74%, alpha/gamma>50:1 19 F NMR determination, silica gel chromatography FP ECOFLEX C18 (20 g) purification (MeCN: H) 2 O＝7:3) 1 H NMR(400MHz,CDCl 3 )δ7.73(d,J＝8.0Hz,2H),7.62(d,J＝8.0Hz,2H),6.18–6.05(m,1H),5.62–5.52(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-95.04(d,J＝9.7Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ140.7(t,J＝28.3Hz),132.7(t,J＝29.5Hz),132.3,126.3(t,J＝5.6Hz),120.8(t,J＝9.3Hz),118.3(t,J＝239.8Hz),118.0,114.0(t,J＝1.7Hz).MS(EI):m/z(％)75,102,152(100),179([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 10 H 7 NF 2 :179.0541；Found:179.0543.
0.1mol% of CuBr was charged into a 50mL Schlenk bottle, and difluoroallylic onium salt (6 mmol,1.0 equiv) represented by the formula C was added thereto, and vacuum-charged with Ar three times. 10.0mL of THF was added and the formula [ C ] was added dropwise]-[Zn]The zinc reagent (1.2 equiv) was stirred at room temperature for 16 hours to effect a reaction. Using fluorobenzene as internal standard reagent (firstly prepared from 19 F NMR measurement α/γ =25: 1) By using 19 F NMR determination of the product yield, NH 4 The reaction was quenched with Cl and diluted to dryness with EtOAc, the aqueous phase was washed with ethyl acetate (3X 10 mL) and the organic phase was Na 2 SO 4 Drying, filtering and collecting. Silica gel chromatography FP ECOFLEX C18 (20 g) purification (MeCN: H 2 O = 7:3) product:
Figure BDA0003821643370000572
827mg,77％yield,α/γ＝25:1 19 f NMR measurement.
And (3) a product:
Figure BDA0003821643370000573
slightly yellow oil, 79mg,88% yield>99:1 19 F NMR determination, silica gel chromatography FP ECOFLEX C18 (20 g) purification (MeCN: H) 2 O＝7:3) 1 H NMR(400MHz,CDCl 3 )δ7.80(s,1H),7.74(d,J＝8.0Hz,2H),7.57(t,J＝7.8Hz,1H),6.20–6.04(m,1H),5.72–5.45(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-94.37(d,J＝9.8Hz,2F). 13 C NMR(126MHz,CDCl 3 )δ137.8(t,J＝28.8Hz),133.5(t,J＝1.6Hz),132.7(t,J＝29.4Hz),129.8(t,J＝5.4Hz),129.5,129.3(t,J＝5.9Hz),120.9(t,J＝9.2Hz),118.1(t,J＝239.6Hz),117.9,112.9.MS(EI):m/z(％)77,102,129,152(100),179([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 10 H 7 NF 2 :179.0545；Found:179.0541.
And (3) a product:
Figure BDA0003821643370000581
yellow oil, 110.4mg,97% yield>99:1 19 F NMR determination, silica gel chromatography FP ECOFLEX C18 (20 g) purification (MeCN: H) 2 O＝7:3) 1 H NMR(400MHz,CDCl 3 )δ8.18(s,1H),8.12(d,J＝7.8Hz,1H),7.70(d,J＝7.8Hz,1H),7.52(t,J＝7.8Hz,1H),6.25–6.07(m,1H),5.59(dt,J＝17.2,2.8Hz,1H),5.52(d,J＝10.8Hz,1H),4.40(q,J＝7.2Hz,2H),1.41(t,J＝7.2Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-93.73(dd,J＝9.8,2.8Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ165.9,136.7(t,J＝28.1Hz),133.3(t,J＝29.9Hz),131.0,130.9,129.8(t,J＝5.5Hz),128.6,126.7(t,J＝5.8Hz),120.3(t,J＝9.2Hz),118.6(t,J＝239.8Hz),61.3,14.3.MS(EI):m/z(％)133,153,181(100),226([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 12 H 12 O 2 F 2 :226.0800；Found:226.0806.
The product is as follows:
Figure BDA0003821643370000582
1.5-fold molar equivalent of difluoroallylium salt of formula C, 1-fold molar equivalent of zinc reagent was applied to give a yellowish oil, 113mg,87% by weight>99:1 19 F NMR measurement, silica gel chromatography purification separation (petroleum ether/ethyl acetate =100 1 H NMR(400MHz,CDCl 3 )δ8.46–8.13(m,1H),7.70(dd,J＝8.6,2.6Hz,1H),7.49–7.44(m,2H),7.43–7.36(m,2H),7.37–7.32(m,1H),6.98–6.80(m,1H),6.24–6.09(m,1H),5.61(dt,J＝17.2,2.8Hz,1H),5.54(d,J＝10.8Hz,1H),5.42(s,2H). 19 F NMR(376MHz,CDCl 3 )δ-92.13(dd,J＝9.7,2.9Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ164.6,144.8(t,J＝6.4Hz),136.9,136.3(t,J＝4.7Hz),133.3(t,J＝30.0Hz),128.5,128.0,128.0,125.4(t,J＝28.5Hz),120.3(t,J＝9.0Hz),118.8(t,J＝237.7Hz),111.1,68.0.MS(EI):m/z(％)65,91(100),138,185,265([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 15 H 13 F 2 ON:261.0960；Found:261.0956.
The product is as follows:
Figure BDA0003821643370000583
brown solid, 133.4mg,95%, alpha/gamma>99:1 19 F NMR measurement, silica gel chromatography separation (petroleum ether/ethyl acetate = 10) mp:51.2-53.5 ℃. 1 H NMR(400MHz,CDCl 3 )δ8.23(d,J＝8.0Hz,1H),7.22–7.15(m,2H),7.01(t,J＝7.4Hz,1H),5.91(dq,J＝17.2,11.2Hz,1H),5.70–5.49(m,1H),5.41(d,J＝11.2,1H)4.05(t,J＝8.4Hz,2H),3.20(t,J＝8.2Hz,2H),2.44(t,J＝7.4Hz,2H),2.09–1.88(m,2H),1.85–1.73(m,2H),1.66–1.50(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-97.67–-98.06(m,2F). 13 C NMR(101MHz,CDCl 3 )δ170.6,142.9,132.9(t,J＝27.5Hz),131.0,127.3,124.4,123.4,121.1(t,J＝238.4Hz),119.0(t,J＝9.5Hz),116.7,47.7,36.8(t,J＝26.5Hz),35.4,27.8,24.0,22.0(t,J＝4.3Hz).MS(EI):m/z(％)119(100),279([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 16 H 19 NOF 2 ([M] + ):279.1429；Found:279.1430.
The product is as follows:
Figure BDA0003821643370000591
colorless oil, 124mg,97%,/γ>99:1 19 F NMR measurement, silica gel chromatography purification separation (petroleum ether/ethyl acetate =100 1 H NMR(400MHz,CDCl 3 )δ6.70(d,J＝8.4Hz,1H),6.48(d,J＝2.4Hz,1H),6.30(dd,J＝8.4,2.4Hz,1H),6.03–5.84(m,3H),5.64(d,J＝17.2Hz,1H),5.44(d,J＝10.8Hz,1H),3.92(t,J＝6.2Hz,2H),2.21–2.02(m,2H),1.97–1.88(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-93.10–-103.05(m,2F). 13 C NMR(101MHz,CDCl 3 )δ154.3,148.2,141.7,132.9(t,J＝27.6Hz),121.2(t,J＝238.4Hz),119.3(t,J＝9.5Hz),107.9,105.6,101.1,98.0,67.9,33.7(t,J＝26.8Hz),22.5(t,J＝4.2Hz).MS(DART):m/z(％)138(100),256([M] + ).HRMS(DART)m/z:([M+H] + )Calculated for C 13 H 15 F 2 O 3 :257.0984；Found:257.0983.
The product is as follows:
Figure BDA0003821643370000592
brown oil, 78.2mg,73% yield>99:1 19 F NMR measurement, silica gel chromatography purification separation (petroleum ether/ethyl acetate =100 1 H NMR(400MHz,CDCl 3 )δ5.97–5.81(m,1H),5.78(s,2H),5.68–5.53(m,1H),5.44(d,J＝10.8Hz,1H),3.79(t,J＝7.8Hz,2H),2.22(s,6H),2.02–1.86(m,2H),1.87–1.77(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-97.55–-98.25(m,2F). 13 C NMR(126MHz,CDCl 3 )δ132.6(t,J＝27.5Hz),127.2,120.9(t,J＝239.3Hz),119.5(t,J＝9.4Hz),105.3,42.8,34.1(t,J＝27.0Hz),23.8(t,J＝3.7Hz),12.4.MS(EI):m/z(％)108(100),213([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 12 H 17 F 2 N:213.1324; found 213.1330 product:
Figure BDA0003821643370000593
colourless oil, 80mg,90% yield>99:1 19 F NMR measurement, silica gel chromatography purification separation (petroleum ether/ethyl acetate =100 1 H NMR(400MHz,CDCl 3 )δ7.68(d,J＝7.6Hz,2H),7.18(d,J＝7.6Hz,2H),5.75(dq,J＝17.4,11.2Hz,1H),5.51–5.34(m,1H),5.27(d,J＝11.2Hz,1H),3.14(t,J＝15.6Hz,2H),1.26(s,12H). 19 F NMR(376MHz,CDCl 3 )δ-96.39–-96.58(m,2F). 13 C NMR(126MHz,CDCl 3 )δ135.8(t,J＝4.4Hz),134.7,132.4(t,J＝26.9Hz),129.9,120.0(t,J＝240.6Hz),119.5(t,J＝9.2Hz),83.8,44.1(t,J＝27.5Hz),24.8.MS(FI):m/z(％)85,117,148,195(100),217,294([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 16 H 21 F 2 O 2 10 B:293.1633；Found:293.1638.
The product is as follows:
Figure BDA0003821643370000594
colorless oil, 66.0mg,90% yield, α/γ =15 19 F NMR determination, purification by silica gel chromatography (Petroleum Ether) 1 H NMR(500MHz,CDCl 3 )δ7.47(d,J＝7.5Hz,4H),7.37(t,J＝7.5Hz,4H),7.31(t,J＝7.5Hz,2H),5.96(dq,J＝17.2,11.1Hz,1H),5.75–5.63(m,1H),5.42(d,J＝11.1Hz,1H),4.45(t,J＝16.5Hz,1H). 19 F NMR(376MHz,CDCl 3 )δ-94.60–-108.06(m,2F). 13 C NMR(126MHz,CDCl 3 )δ137.5(t,J＝2.2Hz),132.7(t,J＝26.4Hz),129.6,128.4,127.3,120.6(t,J＝244.8Hz),120.0(t,J＝9.1Hz),58.8(t,J＝25.1Hz).MS(EI):m/z(％)152,167(100),244([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 16 H 14 F 2 244.1058; found 244.1063 product:
Figure BDA0003821643370000601
colorless and colorlessOil, 51.0mg,80% yield>99:1 19 F NMR determination, reverse phase preparative HPLC purification (MeCN: H) 2 O＝9:1) 1 H NMR(400MHz,CDCl 3 )δ7.33–7.27(m 2H),7.23–7.16(m,3H),5.86(dq,J＝17.2,11.2Hz,1H),5.68–5.56(m,1H),5.44(d,J＝11.2Hz,1H),2.81–2.75(m,1H),2.60–2.53(m,1H),2.06–1.87(m,2H),1.52–1.42(m,1H),1.07(d,J＝6.8Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-104.12(t,J＝12.5Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ141.8,131.6(t,J＝27.3Hz),128.4,128.3,125.9,122.9(t,J＝241.8Hz),119.8(t,J＝9.6Hz),39.7(t,J＝24.8Hz),33.3,31.7(t,J＝3.6Hz),13.0(t,J＝4.8Hz).MS(EI):m/z(％)91(100),131,210([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 13 H 16 F 2 :210.1220；Found:210.1215.
The product is as follows:
Figure BDA0003821643370000602
yellow oil, 112.3mg,79%,. Alpha./gamma>99:1 19 F NMR determination, reverse phase preparative HPLC (MeCN: H) 2 O＝6:4) 1 H NMR(400MHz,CDCl 3 )δ7.98(d,J＝8.8Hz,2H),6.92(d,J＝8.8Hz,2H),5.89(dq,J＝17.4,11.3Hz,1H),5.71–5.61(m,1H),5.48(d,J＝11.3Hz,1H),4.50–4.23(m,2H),2.26–2.06(m,2H),1.64–1.52(m,1H),1.09(d,J＝6.8Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-103.74(dt,J＝241.3,11.6Hz,1F),-105.56(dt,J＝241.3,13.0Hz,1F). 13 C NMR(101MHz,CDCl 3 )δ166.2,163.4,131.5,131.3(t,J＝27.2Hz),122.6,122.5(t,J＝242.0Hz),120.2(t,J＝9.5Hz),113.6,62.3,55.4,37.4(t,J＝25.4Hz),29.2(t,J＝4.1Hz),13.1(t,J＝4.7Hz).MS(EI):m/z(％)135(100),152,284([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 13 H 16 F 2 :284.1219；Found:284.1225.
The product is as follows:
Figure BDA0003821643370000603
yellow oilSubstance, 83mg,60%>99:1 19 F NMR determination, silica gel chromatography separation (Petroleum ether: ethyl acetate = 1:1) 1 H NMR(400MHz,CDCl 3 )diastereomer mixtures: 1 H NMR(400MHz,CDCl3)δ5.84(m,1H),5.64–5.54(m,1H),5.45–5.38(m,1H),4.46–4.40(m,0.86H)(4.38(dd,J＝8.4,2.7Hz,0.14H)),3.67(s,3H),3.65–3.54(m,1H),3.54–3.43(m,1H),2.68–2.53(m,2H),2.22–2.08(m,2H),2.00–1.87(m,2H),1.02(t,J＝6.7Hz,3H). 19 F NMR(376MHz,CDCl 3 ) Diastereomer mixtures of delta-103.76 (dtd, J =240.6,11.0,2.6Hz, 0.46F) (-103.42 (dtd, J =240.8,11.0,2.6Hz, 0.07F)), -104.22 (dtd, J =240.7,11.7,2.6Hz, 0.39F) (-104.49 (dtd, J =241.5,12.2,2.4Hz, 0.07F)), -107.36-108.84 (m, 0.85F) (-107.50-109.05 (m, 0.15F)). 13 C NMR(126MHz,CDCl 3 ) Diastereomer mixtures δ 172.64 (172.62), 169.8 (169.6), 131.6 (t, J =27.1 Hz) (131.5 (t, J =27.1 Hz)), 122.21 (t, J =241.9 Hz) (122.16 (t, J =242.0 Hz)), 120.0 (t, J =9.6 Hz) (119.9 (t, J =9.6 Hz)), 58.64 (58.59), 52.0,47.0 (46.9), 36.9 (t, J =25.2 Hz) (36.5 (t, J =25.2 Hz)), 34.6 (t, J =3.7 Hz) (34.4 (t, J =3.8 Hz)), 29.07 (25 zxft 5725), 24.61 (24.58), 13.51 (t = 3.9) (34.4 (t, J =3.8 Hz)), 29.51 (t, J =3.9, J =3.7 Hz) (34.4 (t, 31 z (%) im) (3470 Hz), 24.61 (t, J =48, 31 z M) (% Hz) ((3432)] + ).HRMS(EI)m/z:([M] + )Calculated for C 13 H 19 O 3 NF 2 275.1328; found 275.1331 product:
Figure BDA0003821643370000611
yellowish oil, 110.9mg,85% yield, α/γ>99:1 19 F NMR measurement, silica gel chromatography purification separation (petroleum ether/ethyl acetate =10 1 H NMR(400MHz,CDCl 3 )δ5.81(dq,J＝17.2,11.2Hz,1H),5.57(dt,J＝17.2,2.6Hz,1H),5.43(d,J＝11.2Hz,1H),4.26–3.95(m,2H),2.71–2.47(m,2H),1.99–1.80(m,1H),1.77–1.67(m,2H),1.41(s,9H),1.36–1.24(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-104.5--107.2(m,2F). 13 C NMR(126MHz,CDCl 3 )δ154.5,131.2(t,J＝27.2Hz),121.5(t,J＝241.4Hz),120.1(t,J＝9.5Hz),79.5,43.1(t,J＝25.8Hz),28.3,24.9.MS(ESI):m/z(％)162(100),284([M+Na] + ).HRMS(ESI)m/z:([M+Na] + )Calculated for C 13 H 21 O 2 NF 2 Na:284.1433；Found:284.1428.
The product is as follows:
Figure BDA0003821643370000612
colorless oil, 56mg,74% yield>50:1 19 F NMR measurement, silica gel chromatography separation (Petroleum Ether 100%) 1 H NMR(500MHz,CDCl 3 )δ7.32(d,J＝8.5Hz,2H),7.24(d,J＝8.5Hz,2H),5.59(dq,J＝17.3,10.5Hz,1H),5.45–5.37(m,1H),5.23(d,J＝11.0Hz,1H),2.37(dd,J＝16.5,9.0Hz,1H),1.75–1.63(m,1H),1.47–1.36(m,1H),1.34(s,9H),1.21–1.13(m,1H). 19 F NMR(376MHz,CDCl 3 )δ-90.04(dt,J＝251.0,10.2Hz),-95.59(dt,J＝251.4,12.4Hz). 13 C NMR(126MHz,CDCl 3 )δ149.2,133.3,133.0(t,J＝28.7Hz),129.3(t,J＝1.6Hz),124.7,120.5(dd,J＝239.0,236.9Hz),118.4(t,J＝9.3Hz),34.4,31.4,23.6(dd,J＝32.1,30.3Hz),20.3(dd,J＝3.9,1.9Hz),5.7(dd,J＝4.9,2.6Hz).MS(EI):m/z(％)45,70(100),159,250([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 16 H 20 F 2 :250.1528；Found:250.1534.
The product is as follows:
Figure BDA0003821643370000613
1 H NMR(600MHz,DMSO-d6)δ5.78(dq,J＝17.4,11.9Hz,1H),5.33(ddt,J＝17.3,2.5,1.3Hz,1H),5.22(d,J＝11.1Hz,1H),0.78(s,9H). 19 F NMR(565MHz,DMSO-d 6 )δ-112.20(d,J＝12.0Hz,2F).MS(FI):m/z(％)134(100)([M] + )；HRMS(FI)m/z:([M] + )Calculated for C 7 H 12 F 2 134.0902; found 134.0903 product:
Figure BDA0003821643370000614
yellow liquid, 131mg,85% yield>11:1， 19 F NMR measurement, silica gel chromatography separation (Petroleum Ether 100%) 1 H NMR(400MHz,CDCl 3 )δ7.68(d,J＝8.4Hz,2H),7.66–7.60(m,4H),7.53–7.45(m,2H),7.44–7.37(m,1H),6.28–6.24(m,1H),5.97–5.92(m,1H). 19 F NMR(376MHz,CDCl 3 )δ-93.08(s,2F). 13 C NMR(126MHz,CDCl 3 )δ143.4,140.0,132.9(t,J＝27.4Hz),128.9,127.9,127.2,127.1,126.9(t,J＝34.7Hz),126.4(t,J＝5.5Hz)，122.5(t，J＝5.9Hz)，117.7(t，J＝243.8Hz).MS(EI):m/z(％)152，203(100)，308([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 15 H 11 F 2 Br:308.0007；Found:308.0013.
The product is as follows:
Figure BDA0003821643370000621
yellowish oil, 97mg,63% yield, α/γ =3:1 is prepared from 19 FNMR assay, when 0.6 equivalents of catalyst were used, the product was 140mg,92% yield, α/γ =50:1, silica gel chromatography separation (petroleum ether/ethyl acetate =100 1 H NMR(400MHz,CDCl 3 )δ7.43–7.28(m,5H),6.27–6.25(m,1H),5.86–5.85(m,1H),4.53(s,2H),3.54(t,J＝6.4Hz,2H),2.34–2.16(m,2H),1.91–1.74(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-98.22(t,J＝16.3Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ138.2,128.4,127.58,127.56,125.5(t,J＝31.7Hz),121.1(t,J＝6.6Hz),120.1(t,J＝244.6Hz),72.8,69.0,32.1(t,J＝25.9Hz),22.6(t,J＝4.1Hz).MS(FI):m/z(％)187(100),304([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 13 H 15 F 2 OBr:304.0269；Found:304.0273.
The product is as follows:
Figure BDA0003821643370000622
yellowish oil, 76.5mg,98% yield when 0.6-fold equivalent of catalyst was used, α/γ =50:1 is prepared from 19 F NMR measurement. 1 H NMR(400MHz,CDCl 3 )δ7.39–7.28(m,5H),5.84–5.83(m,1H),5.61–5.60(m,1H),4.53(s,2H),3.53(t,J＝6.3Hz,2H),2.27–2.15(m,2H),1.82–1.75(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-99.9(t,J＝16.4Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ138.3,135.0(t,J＝32.1Hz),128.4,127.60,127.59,120.0(t,J＝244.4Hz),116.4(t,J＝5.9Hz),72.9,69.0,31.7(t,J＝25.8Hz),22.6(t,J＝4.2Hz).
The product is as follows:
Figure BDA0003821643370000623
colorless oil, 160.9mg,96% yield>99:1 silica gel chromatography separation (petroleum ether/ethyl acetate =100 1 H NMR(400MHz,CDCl 3 )δ6.70(d,J＝8.4Hz,1H),6.49(d,J＝2.4Hz,1H),6.31(dd,J＝8.4,2.4Hz,1H),6.29–6.26(m,1H),5.91(s,2H),5.88–5.85(m,1H),3.93(t,J＝6.2Hz,2H),2.38–2.22(m,2H),1.97–1.86(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-98.34(t,J＝16.2Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ154.2,148.2,141.7,125.4(t,J＝31.5Hz),121.2(t,J＝6.6Hz),120.0(t,J＝244.8Hz),107.9,105.6,101.1,98.1,67.6,32.0(t,J＝26.1Hz),22.3(t,J＝4.1Hz).MS(EI):m/z(％)138(100),334([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 13 H 13 F 2 O 3 Br:334.0011；Found:334.0008.
The product is as follows:
Figure BDA0003821643370000624
colorless oil, 100mg,90%>99：1 19 FNMR determination, silica gel chromatographic separation (petroleum ether/ethyl acetate = 100), using 0.6 equivalents of catalyst CuBr, 1 H NMR(400MHz,CDCl 3 )δ6.29–6.25(m,1H),5.90–5.85(m,1H),2.44(t,J＝7.2Hz,2H),2.34–2.17(m,2H),1.85(p,J＝7.2Hz,2H). 19 F NMR(376MHz,CDCl 3 )δ-98.65(t,J＝16.0Hz). 13 C NMR(101MHzCDCl 3 )δ124.7(t,J＝31.2Hz)121.6(tJ＝6.7Hz)119.3(tJ＝245.4Hz),118.6,34.0(t,J＝26.3Hz),18.5(t,J＝4.3Hz),16.7.MS(FI):m/z(％)144,223(100)([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 7 H 8 F 2 NBr:222.9803；Found:222.9805.
the product is as follows:
Figure BDA0003821643370000631
slightly yellow oil, 71mg,97% yield>99：1 19 F NMR measurement, silica gel chromatography separation (petroleum ether/DCM =20, 1 H NMR(400MHz,CDCl 3 )δ7.46–7.40(m,2H),7.39–7.33(m,3H),5.76(s,1H),5.50(s,1H),3.48(t,J＝6.8Hz,2H),2.02–1.85(m,2H),1.74(p,J＝6.8Hz,2H),1.65–1.54(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-95.99(t,J＝16.2Hz,2F). 13 C NMR(101MHz,CDCl 3 )144.6(t,J＝22.8Hz),136.9,128.4,128.2,128.1,122.3(t,J＝243.1Hz),118.2(t,J＝9.0Hz),44.4,35.4(t,J＝26.4Hz),31.9,19.7(t,J＝4.3Hz).MS(FI):m/z(％)194,244(100)([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 13 H 15 F 2 Cl:244.0825；Found:244.0828.
the product is as follows:
Figure BDA0003821643370000632
yellow oil, 89mg,99% yield>99：1 19 F NMR measurement, silica gel chromatography separation (petroleum ether), 1 H NMR(400MHz,CDCl 3 )δ7.37(d,J＝8.8Hz,2H),7.34(d,J＝8.8Hz,2H),5.70(s,1H),5.48(s,1H),3.48(t,J＝6.6Hz,2H),2.00–1.86(m,2H),1.80–1.70(m,2H),1.64–1.52(m,2H),1.34(s,9H). 19 F NMR(376MHz,CDCl 3 )δ-95.97(t,J＝16.3Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ151.3,144.4(t,J＝23.1Hz),133.9,127.7,125.3,122.5(t,J＝243.1Hz),117.6(t,J＝9.0Hz),44.5,35.5(t,J＝26.5Hz),34.5,31.9,31.3,19.8(t,J＝4.3Hz).MS(FI):m/z(％)57,128,285(100),300([M + ]).HRMS(FI)m/z:([M] + )Calculated for C 17 H 23 F 2 Cl([M + ]):300.1451；Found:300.1450.
the product is as follows:
Figure BDA0003821643370000633
slightly yellow oil, 90mg,95% yield>99：1 19 F NMR measurement, silica gel chromatography separation (petroleum ether/ethyl acetate =100, 1 H NMR(400MHz,CDCl 3 )δ8.03(d,J＝8.2Hz,2H),7.48(d,J＝8.2Hz,2H),5.82(s,1H),5.55(s,1H),4.39(q,J＝7.2Hz,2H),3.47(t,J＝6.4Hz,2H),1.99–1.82(m,2H),1.78–1.68(m,2H),1.63–1.53(m,2H),1.40(t,J＝7.2Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-95.84(t,J＝16.1Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ166.2,144.0(t,J＝23.5Hz),141.3,130.3,129.6,128.0,122.0(t,J＝243.2Hz),119.4(t,J＝8.9Hz),61.1,44.4,35.4(t,J＝26.2Hz),31.8,19.7(t,J＝4.3Hz),14.3.MS(FI):m/z(％)133,151,181,198(100),316([M + ]).HRMS(FI)m/z:([M] + )Calculated for C 16 H 19 F 2 O 2 Cl([M + ]) 316.1036; found 316.1033 product:
Figure BDA0003821643370000634
yellow oil, 57mg,72%>99：1 19 F NMR measurement, silica gel chromatographic separation (petroleum ether/ethyl acetate =50 1), 0.6 equivalents of CuBr used, 1 H NMR(400MHz，CDCl 3 )δ7.72(d,J＝8.0Hz，2H)，7.60(d，J＝8.0Hz，2H)，6.04–5.91(m,1H),5.82–5.70(m,1H),2.17–2.05(m,2H),1.46–1.34(m,2H),1.35–1.18(m,6H),0.87(t,J＝6.6Hz,3H). 19 F NMR(376MHz,CDCl 3 )(Z)δ-86.40(d,J＝13.6Hz),(E)-91.71(dd,J＝10.0,3.3Hz). 13 CNMR(126MHz,CDCl 3 )δ141.6(t,J＝28.7Hz),138.4(t,J＝8.9Hz),132.2,126.4(t,J＝5.5Hz),125.0(t,J＝28.7Hz),118.7(t,J＝238.6Hz),118.1,113.8,31.8,31.5,28.7,28.2,22.5,14.0.MS(DART):m/z(％)185,264([M+H] + ).HRMS(DART)m/z:([M+H] + ):Calculated for C 16 H 20 F 2 n is 264.1558; found 264.1556 product:
Figure BDA0003821643370000641
slightly yellow oil, 67mg,65% yield>99：1 19 F NMR measurement, silica gel chromatographic separation (petroleum ether/ethyl acetate =50 1), 0.6 equivalents of CuBr used, 1 H NMR(400MHz,CDCl 3 )δ6.70(d,J＝8.4Hz,1H),6.48(d,J＝2.4Hz,1H),6.31(dd,J＝8.4,2.4Hz,1H),6.14–6.03(m,0.55H),5.91(s,2H),5.81–5.67(m,0.45H),5.65–5.37(m,1H),3.96–3.88(m,2H),2.34–2.01(m,4H),2.02–1.86(m,2H),1.46–1.36(m,2H),1.36–1.24(m,6H),0.89(t,J＝6.4Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-91.00(q,J＝15.7Hz,0.9F),-94.84–-95.01(m,1.1F). 13 C NMR(101MHz,CDCl 3 ) δ 154.3,148.2,141.7,138.5 (t, J =6.1 Hz) (136.3 (t, J =9.0 Hz)), 124.9 (t, J =24.5 Hz) (124.4 (t, J =25.1 Hz)), 122.5 (t, J =239.0 Hz) (121.50 (t, J =237.9 Hz)), 107.9,105.6,101.1,98.1,68.0,35.2 (t, J =27.4 Hz) (34.13 (t, J =27.4 Hz)), 31.8,31.62 (31.60), 29.3,28.9 (28.8), 28.3 (28.4), 22.6 (22.5), 14.0 (isomer data in parentheses). MS (DART M/z (%) 322 (100), 341 ([ M, J) ([ M ] M = 9.8), 28.3 (28.4), 22.5), 14.0 (isomer data in parentheses) ] + ]).HRMS(DART)m/z:([M+H] + )Calculated for C 19 H 27 F 2 O 3 :341.1923Found:341.1920
The product is as follows:
Figure BDA0003821643370000642
slightly yellow oil, 64mg,51% yield>99：1 19 F NMR determination, silica gel chromatography separation (petroleum ether), 0.6 equivalent of CuBr, 1 H NMR(400MHz,CDCl 3 )δ6.13–5.98(m,0.8H),5.80–5.67(m,0.2H),5.60–5.37(m,1H),3.54(t,J＝6.5Hz,2H),2.30–2.18(m,0.4H),2.14–2.06(m,1.6H),2.00–1.78(m,4H),1.70–1.54(m,2H),1.47–1.34(m,2H),1.34–1.22(m,6H),0.89(t,J＝6.8Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-90.74(q,J＝14.9Hz,0.4F),-93.83–-95.92(m,1.6F). 13 C NMR(101MHz,CDCl 3 )δ138.5(t,J＝6.1Hz),136.3(t,J＝9.1Hz),124.75(t,J＝26.5Hz)(124.30(t,J＝27.1Hz)),121.4(t,J＝237.9Hz),44.6,36.7(t,J＝27.2Hz),32.1,31.8,31.6,28.8,28.5,22.6,20.0(t,J＝4.3Hz),14.1.MS(FI):m/z(％)232(100),252([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 13 H 23 F 2 Cl:252.1451；Found:252.1454.
the product is as follows:
Figure BDA0003821643370000643
yellowish oil (108.6 mg,96% yield) was chromatographed on silica gel (petroleum ether/ethyl acetate =100 1 H NMR(400MHz,Chloroform-d)δ7.40–7.27(m,5H),5.91(dq,J＝17.3,10.9Hz,1H),5.62(dt,J＝17.4,2.7Hz,1H),5.42(d,J＝11.0Hz,1H),4.51(s,2H),3.52(t,J＝6.2Hz,2H),2.12–1.94(m,2H),1.86–1.73(m,H). 19 F NMR(376MHz,Chloroform-d)δ-97.92–-98.22(m,2F). 13 C NMR(126MHz,Chloroform-d)δ138.32,132.93(t,J＝27.5Hz),128.37,127.59,121.30(t,J＝238.4Hz),119.15(t,J＝9.5Hz),72.85,69.33,33.90(t,J＝26.8Hz),22.77(t,J＝4.2Hz).MS(EI):m/z(％)91(100),226(M + ).HRMS:Calculated for C 13 H 16 OF 2 :226.1167；Found:226.1164.
0.5mol% of CuBr was charged into a 50mL Schlenk bottle, a difluoroallylic onium salt represented by the formula C (4.2mmol, 1.0 equiv) was added, and vacuum-charged with Ar three times. 10.0mL of THF was added and the formula [ C ] was added dropwise]-[Zn]The zinc reagent (1.2 equiv) was stirred at room temperature for 16 hours to effect a reaction. Using fluorobenzene as internal standard reagent (firstly prepared from 19 F NMR measurement α/γ =10: 1) By using 19 F NMR determination of product yield, NH 4 The reaction was quenched with Cl and diluted with EtOAc and dried, the aqueous phase was washed with ethyl acetate (3X 10 mL) and the organic phase was Na 2 SO 4 Drying, filtering and collecting.
The product obtained by gram-grade reaction:
Figure BDA0003821643370000651
micro-butter oil, 676.3mg,81% yeiled, isolated by silica gel chromatography (DCM: PE = 1:5).
The product is as follows:
Figure BDA0003821643370000652
colorless oil (79.7mg, 90% yield) was purified and separated by silica gel chromatography (petroleum ether/ethyl acetate =100 1 H NMR(400MHz,Chloroform-d)δ7.68(d,J＝7.7Hz,2H),7.18(d,J＝7.7Hz,2H),5.75(dq,J＝17.4,11.1Hz,1H),5.51–5.34(m,1H),5.27(dt,J＝11.0,0.8Hz,1H),3.14(t,J＝15.6Hz,2H),1.26(s,12H). 19 F NMR(376MHz,Chloroform-d)δ-96.49(ddd,J＝16.7,14.0,10.2Hz,2F). 13 C NMR(126MHz,Chloroform-d)δ135.83(t,J＝4.4Hz),134.73,132.36(t,J＝26.9Hz),129.92,120.03(t,J＝240.6Hz),119.54(t,J＝9.2Hz),83.78,44.10(t,J＝27.5Hz),24.84.MS(EI):m/z(％)294(M+).HRMS:Calculated for C16H21F210B:293.1638；Found:293.1633.
The product is as follows:
Figure BDA0003821643370000653
colorless oil (44.0mg, 90% yield), silica gel chromatography for purification and separation (petroleum ether) 1 H NMR(400MHz,Chloroform-d)δ7.29(m 2H),7.23–7.16(m,3H),5.86(dq,J＝17.4,11.5Hz,1H),5.68–5.56(m,1H),5.44(d,J＝11.0Hz,1H),2.77(ddd,J＝14.8,10.1,5.3Hz,1H),2.56(ddd,J＝13.8,10.1,6.6Hz,1H),2.06–1.87(m,2H),1.47(ddt,J＝13.5,9.8,4.8Hz,1H),1.07(d,J＝6.8Hz,3H). 19 F NMR(376MHz,Chloroform-d)δ-104.12(t,J＝12.5Hz,2F). 13 C NMR(101MHz,Chloroform-d)δ141.78,131.57(t,J＝27.3Hz),128.41,128.34,125.93,122.88(t,J＝241.8Hz),119.77(t,J＝9.6Hz),39.65(t,J＝24.8Hz),33.27,31.70(t,J＝3.6Hz),13.00(t,J＝4.8Hz).MS(EI):m/z(％)91(100),210(M+).HRMS:Calculated for C 13 H 16 F 2 210.1220; found 210.1215 product:
Figure BDA0003821643370000654
orange oil, 48.1mg,82% yield, α/γ =50:1 is prepared from 19 F NMR measurement, silica gel chromatography separation (petroleum ether/ethyl acetate = 100) 1 H NMR(400MHz,Chloroform-d)δ6.27(dd,J＝2.3,1.2Hz,1H),5.87(dd,J＝2.4,1.2Hz,1H),5.80(s,2H),3.94–3.72(m,2H),2.25(s,6H),2.23–2.07(m,2H),1.80(tt,J＝10.5,6.7Hz,2H). 19 F NMR(376MHz,Chloroform-d)δ-98.06(t,J＝16.0Hz,2F). 13 C NMR(101MHz,Chloroform-d)δ127.17,124.95(t,J＝31.4Hz),121.43(t,J＝6.7Hz),119.85(t,J＝245.2Hz),105.37,42.62,32.40(t,J＝26.2Hz),23.74(t,J＝3.7Hz),12.42.MS(FI):m/z(％)138(100),291([M] + ).HRMS:Calculated for C 12 H 16 NF 2 Br([M] + ):291.0431；Found:291.0429.
The above products
Figure BDA0003821643370000661
Can be further used for the preparation of coupling reaction
Figure BDA0003821643370000662
The reaction is shown below:
Figure BDA0003821643370000663
pd (PPh) 3 ) 4 (8.6 mg,5 mol%) was charged into a 25mL Schlenk flask, and the formula CuI (2.8 mg, 10mol%) was added, and vacuum charged with Ar three times. Adding the compound under the protection of argon
Figure BDA0003821643370000664
(45.7mg, 0.15mmol, 1.0equiv), dry diisopropylethylamine EtN (i-Pr) 2 (52.2. Mu.L, 0.3mmol,2.0 equiv) and phenylacetylene (16.1. Mu.L, 0.15mmol,1.0 equiv), 20ml of DMF was added to the reaction mixture, and the mixture was reacted at 40 ℃ for 24 hours with stirring. Cooling to room temperature, adding water, extracting with ethyl acrylate, separating, washing organic phase with saturated saline (brine) to obtain Na 2 SO 4 Drying, distilling under reduced pressure, and purifying by FP ECOFLEX C18 (20 g) chromatography to obtain compound
Figure BDA0003821643370000665
34mg,70％yield， 1 H NMR(400MHz,CDCl 3 )δ7.50–7.45(m,2H),7.39–7.27(m,8H),5.95–5.90(m,1H),5.82–5.78(m,1H),4.52(s,2H),3.56(t,J＝6.4Hz,2H),2.35–2.19(m,2H),1.91–1.80(m,2H). 19 F NMR(376MHz,CDCl 3 )δ-99.31(t,J＝16.4Hz,2F). 13 C NMR(126MHz,CDCl 3 )δ138.3,131.7,128.8,128.3,128.2,128.1(t,J＝28.8),127.6,127.5,124.1(t,J＝6.9Hz),122.2,120.8(t,J＝244.1Hz),92.1,84.4(t,J＝4.3Hz),72.8,69.3,33.0(t,J＝26.1Hz),22.7(t,J＝4.2Hz).MS(FI):m/z(％)91(100),129,235,326([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 21 H 19 F 2 O:326.1477；Found:326.1475.
The product is as follows:
Figure BDA0003821643370000666
slightly yellow oil (52.5mg, 83% yield), silica gel chromatography purification (100% petroleum ether) 1 H NMR(400MHz,Chloroform-d)δ7.46(d,J＝8.9Hz,2H),7.41(d,J＝8.5Hz,2H),7.21(t,J＝7.9Hz,1H),6.99–6.92(m,1H),6.90–6.81(m,2H),5.71(td,J＝1.8,1.0Hz,1H),5.65(s,1H),3.74(s,3H),1.33(s,9H). 19 F NMR(376MHz,Chloroform-d)δ-90.08(s,2F). 13 C NMR(101MHz,Chloroform-d)δ159.15,153.04(t,J＝1.7Hz),145.40(t,J＝26.6Hz),137.90,133.40(t,J＝27.6Hz),129.08,125.66(t,J＝5.5Hz),125.21,120.74,120.57(t,J＝241.8Hz)，119.39(t，J＝8.0Hz)，113.85，113.68，55.10，34.71，31.20.MS(FI):m/z(％)316(100)，316([M] + ).HRMS:Calculated for C 20 H 22 F 2 :316.1629；Found:316.1633.
The product is as follows:
Figure BDA0003821643370000671
yellowish oil, 54.2mg,76% yield, α/γ =25 19 F NMR determination, purification by silica gel chromatography (Petroleum Ether) 1 H NMR(400MHz,Chloroform-d)δ7.26(t,J＝8.0Hz,1H),7.00(ddd,J＝7.7,1.8,1.0Hz,1H),6.96(t,J＝2.1Hz,1H),6.88(ddd,J＝8.2,2.7,0.9Hz,1H),5.73(dt,J＝1.8,1.0Hz,1H),5.48(q,J＝1.2Hz,1H),3.81(s,3H),3.56(t,J＝6.3Hz,2H),2.09–1.90(m,2H),1.69–1.55(m,2H),0.84(s,9H),-0.01(s,6H). 19 F NMR(376MHz,Chloroform-d)δ-95.65(t,J＝16.6Hz,2F). 13 C NMR(101MHz,Chloroform-d)δ159.38,144.70(t,J＝23.3Hz),138.41,129.31,122.66(t,J＝242.7Hz),120.58,118.03(t,J＝8.9Hz),113.57,62.12,55.19,32.80(t,J＝26.4Hz),25.83,18.19,-5.43.MS(FI):m/z(％)356(100),356(M + ).HRMS:Calculated for C 19 H 30 F 2 O 2 Si:356.1984；Found:356.1978.
The product is as follows:
Figure BDA0003821643370000672
yellowish oil (27.9 mg,73% yield), silica gel chromatography and separation (petroleum ether) 1 H NMR(400MHz,Chloroform-d)δ7.35(s,4H),5.72–5.62(m,1H),5.46(s,1H),3.56(t,J＝6.2Hz,2H),1.98(tt,J＝16.4,8.2Hz,2H),1.71–1.49(m,2H),1.32(s,9H),0.82(s,9H),-0.02(s,6H). 19 F NMR(376MHz,Chloroform-d)δ-95.71(t,J＝16.6Hz,2F). 13 C NMR(101MHz,Chloroform-d)δ151.12,144.61(t,J＝23.2Hz),134.01,125.21,127.70,128.82–122.39(m),117.37(t,J＝8.9Hz),62.13,34.52,32.86(t,J＝26.4Hz),31.26,25.85,18.20,-0.02,-5.41.MS(FI):m/z(％)325(100),382(M + ).HRMS:Calculated for C 22 H 36 F 2 OSi 382.2504; found 382.2498 product:
Figure BDA0003821643370000673
yellowish oil (74mg, 90% yield), silica gel chromatography and separation (petroleum ether) 1 H NMR(400MHz,Chloroform-d)δ7.35(d,J＝8.8Hz,2H),6.88(d,J＝8.8Hz,2H),5.67(s,1H),5.43(s,1H),3.82(s,3H),3.47(t,J＝6.4Hz,2H),2.00–1.83(m,2H),1.79–1.68(m,2H),1.62–1.50(m,2H). 19 F NMR(376MHz,Chloroform-d)δ-95.97(t,J＝16.1Hz,2F). 13 C NMR (101mhz, chloroform-d) δ 159.6,144.0 (t, J =23.0 Hz), 129.27,129.25,122.5 (t, J =243.0 Hz), 117.1 (t, J =9.1 Hz), 113.7,55.2,44.5,35.4 (t, J =26.5 Hz), 31.9,19.8 (t, J =4.3 Hz).
Figure BDA0003821643370000681
Yellow oil, 94mg,66% yield, e/Z =4.6>99:1， 19 F NMR determination, silica gel chromatographic separation (petroleum ether/ethyl acetate = 1:1), 0.6 equivalents of CuBr used, 1 H NMR(400MHz,CDCl 3 )δ8.07(d,J＝8.4Hz,2H),7.55(d,J＝8.4Hz,0.30H)(7.60(d,J＝8.4Hz,1.70H),6.00–5.87(m,1H),5.86–5.70(m,1H),4.40(t,J＝6.2Hz,2H),2.85(t,J＝6.2Hz,2H),2.63(q,J＝6.8Hz,4H),2.16–2.01(m,2H),1.45–1.32(m,2H),1.31–1.21(m,6H),1.06(t,J＝7.2Hz,6H),0.86(t,J＝6.8Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-85.78(d,J＝12.7Hz,0.28F),-91.12(d,J＝9.2Hz,1.72F). 13 C NMR(126MHz,CDCl 3 )δ165.9,141.4(t,J＝28.2Hz),137.9(t,J＝8.9Hz),131.4,129.6,125.6(t,J＝5.4Hz),125.5(t,J＝29.0Hz),119.3(t,J＝237.9Hz),63.4,50.9,47.8,31.8,31.5,28.7,28.2,22.5,14.0,11.8.MS(DART):m/z(％)382(100)([M+H] + ).HRMS(DART)m/z:([M+H] + )Calculated for C 19 H 27 F 2 O 3 :382.2552；Found:382.2550.
application example 3
Step (1) 2.5mol% of CuBr was charged into a 25mL Schlenk bottle, a difluoroallylic onium salt represented by formula C (0.5 mmol,1.0 equiv) was added, and vacuum charging with Ar was carried out three times. 2.0mL of THF was added and the formula [ C ] was added dropwise]-[Zn]The zinc reagent (1.2 equiv) was stirred at room temperature for 3 hours to effect a reaction. Using fluorobenzene as internal standard reagent 19 F NMR determination of the product yield, NH 4 The reaction was quenched with Cl and diluted to dryness with EtOAc, the aqueous phase was washed with ethyl acetate (3X 10 mL) and the organic phase was Na 2 SO 4 Drying, filtering and collecting. The product after chromatographic purification is directly used for the next preparation.
Step (2): at 25 ℃, K is added into a 25mL flask 2 OsO 2 (OH) 4 (9.2mg, 5mol%), NMO (135mg, 1mmol, 2.0equiv) and the above-obtained compound were stirred for 24 hours, diluted with ethyl acetate, and diluted with saturated NaHCO 3 Washed with brine and Na 2 SO 4 Drying, filtering and concentrating. Purification by silica gel chromatography gave the following product.
Step (1):
Figure BDA0003821643370000682
step (2):
Figure BDA0003821643370000683
the product is as follows:
the product is as follows:
Figure BDA0003821643370000691
viscous yellow oil, 203mg,85% yield, α/γ =99:1 is prepared from 19 F NMR measurement, dr = 1:1), silica gel chromatographic purification separation (petroleum ether/ethyl acetate =100 1 H NMR(400MHz,CDCl 3 )δ8.08(d,J＝8.2Hz,2H),7.60(d,J＝8.2Hz,2H),5.94(d,J＝3.6Hz,1H),5.50(d,J＝2.8Hz,1H),4.62(d,J＝3.6Hz,1H),4.41–4.27(m,2H),4.17–4.02(m,3H),3.84–3.65(m,2H),3.19(t,J＝6.2Hz,1H),2.22(s,1H),1.55(s,3H),1.41(s,3H),1.32(s,3H),1.26(s,3H). 19 F NMR(376MHz,CDCl 3 )δ-105.10(dd,J＝255.5,8.3Hz,0.5F),-105.23(dd,J＝255.5,8.4Hz,0.5F),-110.67(dd,J＝255.5,13.4Hz,1F). 13 C NMR(101MHz,CDCl 3 )δ164.5,139.2(t,J＝25.7Hz),131.2,129.7,126.1(t,J＝6.4Hz),120.4(t,J＝248.6Hz),112.4,109.5,105.0,83.3,79.8,76.9,73.9(t,J＝29.7Hz),72.5,67.2,60.9,26.8,26.6,26.1,25.1.MS(DART):m/z(％)274,417(100),475([M+H] + ).HRMS(DART)m/z:([M+H] + )Calculated for C 22 H 29 F 2 O 9 :475.1774；Found:475.1771.
The product is as follows:
Figure BDA0003821643370000692
yellow viscous oil (150mg, 71% yield, two steps, α/γ =99 19 F NMR determination, dr = 1:1), silica gel chromatographic purification (petroleum ether/ethyl acetate = 1:1) 1 H NMR(400MHz,CDCl 3 )δ5.85(d,J＝3.6Hz,1H),4.51(d,J＝4.0Hz,1H),4.28(q,J＝6.4Hz,1H),4.11(dd,J＝7.4,3.0Hz,1H),4.05(dd,J＝8.6,6.2Hz,1H),3.96(dd,J＝8.8,6.0Hz,1H),3.83(d,J＝3.2Hz,1H),3.81–3.72(m,3H),3.63–3.55(m,1H),3.54–3.46(m,1H),3.33(s,1H),2.57(s,1H),2.03–1.78(m,2H),1.63–1.49(m,4H),1.47(s,3H),1.43–1.37(m,5H),1.33(s,3H),1.30(s,3H). 19 F NMR(376MHz,CDCl 3 )δ-108.22–-109.84(m,1F),-110.86–-112.38(m,1F). 13 C NMR(126MHz,CDCl 3 )δ123.7(t,J＝244.4Hz),111.7,108.9,105.1,82.3,82.0,81.0,72.6(dd,J＝29.8,27.4Hz),72.4,70.2,67.0,61.0(t,J＝4.0Hz),32.8(t,J＝23.9Hz),29.3,26.7,26.6,26.1,25.8,25.2,21.0(t,J＝4.3Hz).MS(FI):m/z(％)101(100),425([M-CH 3 ] + ).HRMS(FI)m/z:([M+H] + )Calculated for C 20 H 35 F 2 O 8 ([M+H] + ):441.2295；Found:441.2301.
The product is as follows:
Figure BDA0003821643370000693
brown solid, 127mg,60% yield, two steps, α/γ =99:1 is prepared from 19 F NMR determination dr =1:1, silica gel chromatographic purification separation (petroleum ether/ethyl acetate = 1:1) 1 H NMR(400MHz,CDCl 3 )δ7.19(d,J＝8.6Hz,1H),6.70(d,J＝8.6Hz,1H),6.64(s,1H),3.98(t,J＝6.0Hz,2H),3.92–3.76(m,3H),2.98–2.82(m,2H),2.50(dd,J＝18.9,8.6Hz,1H),2.43–2.34(m,1H),2.29–1.89(m,9H),1.67–1.32(m,5H),1.30–1.20(m,1H),0.90(s,3H). 19 F NMR(376MHz,CDCl 3 )δ-107.13–-110.53(m,1F),-111.62--112.72(m,1F). 13 C NMR(101MHz,CDCl 3 )δ221.3,156.8,137.8,132.2,126.3,123.8(t,J＝245.7Hz),114.6,112.1,77.2,72.6(dd,J＝30.3,27.2Hz),67.0,61.0(t,J＝3.9Hz),50.4,48.0,43.9,38.3,35.9,31.5,29.9(t,J＝21.1Hz),29.6,26.5,25.9,21.6,13.8.MS(ESI):m/z(％)55(100),74,185,270,422([M] + ).HRMS(ESI)m/z:([M+Na] + )Calculated for C 24 H 32 F 2 O 4 Na:445.2161；Found:445.2156.
Application example 4
2.5mol% of CuBr was charged into a 25mL Schlenk bottle, a difluoroallylic onium salt represented by the formula C (0.5 mmol,1.0 equiv) was added, and vacuum-charged with Ar three times. 2.0mL of THF was added and the formula [ C ] was added dropwise]-[Zn]The zinc reagent (1.2 equiv) was stirred at room temperature for 3 hours to effect a reaction. Takes fluorobenzene as an internal standard reagent 19 F NMR determination of product yield, NH 4 The reaction was quenched with Cl and diluted to dryness with EtOAc, the aqueous phase was washed with ethyl acetate (3X 10 mL) and the organic phase was Na 2 SO 4 Drying, filtering and collecting. The product after chromatographic purification is directly used for the next preparation reaction.
A25 mL Schlenk bottle was evacuated and backfilled with Ar (3 times). Cyclohexene (4mmol, 8.0equiv) was then added. BH 3. THF (2mmol, 4.0 equiv) was added dropwise at 0 ℃ in an ice bath. After stirring for 5 minutes, the reaction mixture was warmed to room temperature and stirred for 1 hour. The crude product was added. The resulting mixture was stirred at room temperature for 2 hours. Cooling to 0 deg.C, adding NaOH (7mmol, 14.0equiv, 2m) dropwise, then adding H 2 O 2 (8mmol, 16.0equiv,30% by weight). After stirring for 15 minutes, the reaction mixture was warmed to room temperature and stirred for 2 hours. The resulting mixture was treated with saturated Na 2 O 3 And diluted with EtOAc. The aqueous phase was extracted with ethyl acetate (3X 10 ml). The combined organic layers were washed with Na2SO 4 Dried, filtered and concentrated. The product was purified by silica gel chromatography.
The first step is as follows:
Figure BDA0003821643370000701
the second step is that:
Figure BDA0003821643370000702
the product is as follows:
Figure BDA0003821643370000703
yellow oilSubstance, 136mg,92% yield, three steps, α/γ =45:1 is prepared from 19 F NMR determination, silica gel chromatography, purification and isolation (Petroleum ether/ethyl acetate = 3:1) 1 H NMR(400MHz,CDCl 3 )δ3.87(t,J＝6.2Hz,2H),3.67(s,3H),2.30(t,J＝7.6Hz,2H),2.12(tt,J＝17.0,6.1Hz,2H),1.94–1.77(m,2H),1.64–1.57(m,2H),1.52–1.41(m,2H),1.36–1.23(m,12H). 19 F NMR(376MHz,CDCl 3 )δ-97.04(p,J＝17.0Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ174.4,125.1(t,J＝240.3Hz),57.0(t,J＝5.5Hz),51.4,38.9(t,J＝24.5Hz),37.0(t,J＝24.8Hz),34.0,29.25,29.22,29.21,29.1,29.0,24.9,22.2(t,J＝4.7Hz).MS(FI):m/z(％)74(100),87,149,224,294([M] + ).HRMS(FI)m/z:([M] + )Calculated for C 15 H 28 F 2 O 3 :294.2001；Found:294.2003.
The product is as follows:
Figure BDA0003821643370000704
yellow oil, 68mg,66% yield, three steps, α/γ =48:1 is prepared from 19 F NMR determination, silica gel chromatography separation (petroleum ether/ethyl acetate = 5:1) 1 H NMR(400MHz,CDCl 3 )δ3.87(t,J＝6.2Hz,2H),2.12(tt,J＝17.1,6.2Hz,2H),1.96–1.77(m,2H),1.53–1.41(m,2H),1.35–1.27(m,10H),0.88(t,J＝6.8Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-97.07(p,J＝17.0Hz). 13 C NMR(126MHz,CDCl 3 )δ125.2(dd,J＝241.4,239.3Hz),57.1(t,J＝5.4Hz),38.9(t,J＝24.4Hz),37.0(t,J＝24.8Hz),31.8,29.3,29.1,22.6,22.2(t,J＝4.5Hz),14.1.MS(FI):m/z(％)85(100),124,168,188([M-HF] + ).HRMS(FI)m/z:([M] + )Calculated for C 11 H 22 F 2 O:208.1633；Found:208.1637.
The product is as follows:
Figure BDA0003821643370000711
yellow oil, 123mg,84%, yield, three steps, α/γ =99:1 is prepared from 19 F NMR measurement, silica gel chromatography separation (Petroleum Ether/Ethyl acetate)＝5:1) 1 H NMR(400MHz,CDCl 3 )δ7.41(d,J＝8.4Hz,2H),7.05(d,J＝8.4Hz,2H),3.85(t,J＝6.0Hz,2H),2.62(t,J＝7.2Hz,2H),2.18–2.04(m,2H),1.97–1.74(m,4H),1.65(br,1H). 19 F NMR(376MHz,CDCl 3 )δ-97.30(p,J＝16.8Hz,2F). 13 C NMR(126MHz,CDCl 3 )δ140.3,131.4,130.1,124.78(t,J＝240.6Hz),119.7,56.8(t,J＝5.6Hz),38.9(t,J＝24.4Hz),36.2(t,J＝25.1Hz),34.6,23.6(t,J＝4.6Hz).MS(EI):m/z(％)90,182(100),203,292([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 12 H 15 F 2 OBr:292.0269；Found:292.0272.
Application example 5
0.1mol% of CuBr was charged in a 50mL Schlenk bottle, a difluoroallylic onium salt (5 mmol,1.0 equiv) represented by the formula C was added, and vacuum-charged with Ar three times. 10.0mL of THF was added and the formula [ C ] was added dropwise]-[Zn]The zinc reagent (1.2 equiv) was stirred at room temperature for 10 hours to effect a reaction. Using fluorobenzene as internal standard reagent 19 F NMR determination of product yield, NH 4 The reaction was quenched with Cl and diluted to dryness with EtOAc, the aqueous phase was washed with ethyl acetate (3X 10 mL) and the organic phase was Na 2 SO 4 Drying, filtering and collecting. The obtained intermediate is subjected to double bond reduction through Pd/C to obtain a target product, and the reduction conditions are as follows: pd/C (21.2mg, 10%) and 0.2mmol of the above product were added to 2mL of DCM, and H was bubbled at room temperature 2 (1atm)24h。
Figure BDA0003821643370000712
The product is as follows:
Figure BDA0003821643370000713
yellow oil, 1.31g,88% yield, α/γ =50:1 is prepared from 19 F NMR measurement, FP ECOFLEX C18 (20 g) (MeCN: H 2 O = 6:4) separation and purification, 1 H NMR(400MHz,CDCl 3 )δ8.09(d,J＝8.0Hz,2H),7.57(d,J＝8.0Hz,2H),6.14(dq,J＝17.4，10.6Hz，1H)，5.57(dt，J＝17.4，2.9Hz，1H)，5.51(d，J＝10.6Hz，1H)，4.42(t，J＝6.2Hz，2H)，2.87(t,J＝6.2Hz,2H),2.65(q,J＝7.2Hz,4H),1.08(t,J＝7.2Hz,6H). 19 F NMR(376MHz,CDCl 3 )δ-94.47(d,J＝9.6Hz,2F). 13 C NMR(101MHz,CDCl 3 )δ165.7,140.4(t,J＝27.4Hz),133.2(t,J＝29.3Hz),131.7,129.6,125.5(t,J＝5.6Hz),120.2(t,J＝9.2Hz),118.7(t,J＝239.1Hz),63.5,50.8,47.6,11.9.MS(DART):m/z(％)86(100),105,181,225,297([M] + ).HRMS(DART)m/z:([M+H] + )Calculated for C 16 H 21 F 2 O 2 N:298.1613；Found:298.1610.
applications of example 6
2.5mol% of CuBr was charged into a 25mL Schlenk bottle, a difluoroallylic onium salt (1mmol, 1.0 equiv) represented by the formula C was added, and vacuum-charged with Ar three times. 3.0mL of THF was added and the formula [ C ] was added dropwise]-Zn]The zinc reagent (1.2 equiv) was stirred at room temperature for 3 hours to effect a reaction. NH (NH) 4 The reaction was quenched with Cl and diluted with EtOAc, the aqueous phase was washed with ethyl acetate (3X 10 mL), and the organic phase was Na 2 SO 4 Drying, filtering and collecting the product. The difluoro compound obtained can react with 1-octene in DCM under the action of Grubbs generation II catalyst to obtain a compound 8, and the compound 8 can be subjected to Pd/C reduction reaction and hydrolysis reaction to obtain a final product compound 9.
Figure BDA0003821643370000721
The product is as follows:
Figure BDA0003821643370000722
yellowish oil, 211mg,90% yield, α/γ =50:1 is prepared from 19 F NMR measurement, FP ECOFLEX C18 (20 g) (MeCN: H) 2 O = 7:3) separation and purification 1 H NMR(400MHz,CDCl 3 )δ5.89(dq,J＝17.4,11.0Hz,1H),5.60(dt,J＝17.4,2.5Hz,1H),5.40(d,J＝11.0Hz,1H),4.12(q,J＝7.2Hz,2H),2.29(t,J＝7.6Hz,2H),1.95–1.82(m,2H),1.68–1.58(m,2H),1.50–1.41(m,2H),1.41–1.27(m,4H),1.25(t,J＝7.2Hz,3H). 19 F NMR(376MHz,CDCl 3 )δ-97.73–-98.06(m,2F). 13 C NMR(101MHz,CDCl 3 )δ173.7,133.1(t,J＝27.7Hz),121.3(t,J＝238.4Hz),118.9(t,J＝9.5Hz),60.1,37.0(t,J＝26.4Hz),34.2,28.9,28.8,24.7,22.1(t,J＝4.3Hz),14.2.MS(EI):m/z(％)88(100),126,234([M] + ).HRMS(EI)m/z:([M] + )Calculated for C 12 H 20 F 2 O 2 :234.1426；Found:234.1430.
All documents referred to herein are incorporated by reference into this application as if each were individually incorporated by reference. Furthermore, it should be understood that various changes and modifications of the present invention can be made by those skilled in the art after reading the above teachings of the present invention, and these equivalents also fall within the scope of the present invention as defined by the appended claims.

Claims (15)

1. A 3,3-difluoroallylium salt as shown in formula C,
Figure FDA0003821643360000011
wherein Z = S, se or Te; x is an anion;
R 1 、R 2 、R 3 and R 4 Independently H, F, cl, br, I, C 1 -C 20 By one or more R 5 Substituted C 1 -C 20 Alkyl of (C) 1 -C 20 By one or more R 6 Substituted C 1 -C 20 Heteroalkyl of (a), C 6 -C 20 Aryl of (a) by one or more R 7 Substituted C 6 -C 20 Aryl, 5-20 membered heteroaryl or substituted with one or more R 8 Substituted 5-20 membered heteroaryl; wherein, said C 1 -C 20 The heteroatom or heteroatom group of the heteroalkyl group of (a) is selected from C (= O), S (= O) 2 、SO 2 NR 1’ R 2’ 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of the hetero atoms and hetero atom groups is 1 or more; the 5-20 membered heteroaryl has heteroatoms selected from S, O, N, si, P and B, and the number of the heteroatoms is 1 or more;
or, R 1 And R 4 Together with the attached Z form: 5-20 membered heterocycloalkyl, substituted by one or more R 9 Substituted 5-20 membered heterocycloalkyl, 5-20 membered heteroaryl or substituted with one or more R 10 Substituted 5-20 membered heteroaryl; the heteroatom or heteroatom group of the 5-to 20-membered heterocycloalkyl is selected from C (= O), S, S (= O), S (= O) 2 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of the hetero atoms and hetero atom groups is 1 or more; the heteroatom or heteroatom group of the 5-20 membered heteroaryl is selected from C (= O), S, S (= O), S (= O) 2 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of hetero atoms and hetero atom groups is 1 or more;
each R 5 、R 6 、R 7 、R 8 、R 9 And R 10 Independently F, cl, br, I, C 1 -C 20 Alkyl of (C) 3 -C 20 Cycloalkyl of, C 6 -C 20 Aryl of (C) 2 -C 20 Alkynyl of (A), C 2 -C 20 Alkenyl of, C 1 -C 20 By one or more R 1a Substituted C 1 -C 20 By one or more R 1b Substituted C 3 -C 20 By one or more R 1c Substituted C 6 -C 20 Aryl of (a), one or more R 1d Substituted C 2 -C 20 By one or more R 1e Substituted C 1 -C 20 By one or more R 1f Substituted C 2 -C 20 Alkenyl of (a); said C 1 -C 20 The heteroatom or heteroatom group of the heteroalkyl group of (a) is selected from C (= O), S (= O) 2 、SO 2 NR 1’ R 2’ 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of hetero atoms and hetero atom groups is 1 or more;
each R 1’ 、R 2’ 、R 3’ And R 4’ Independently is C 1 -C 20 Alkyl of (C) 3 -C 20 Cycloalkyl of, C 6 -C 20 Aryl of (a) by one or more R 1a Substituted C 1 -C 20 By one or more R 1b Substituted C 3 -C 20 By one or more R 1c Substituted C 6 -C 20 Aryl of (a);
each R 1a 、R 1b 、R 1c 、R 1d 、R 1e And R 1f Independently F, cl, br, I, N 3 、C 1 -C 20 Alkyl of (C) 6 -C 20 Aryl of (a) or independently by three C 1 -C 4 Alkyl-substituted silane groups.
2. The 3,3-difluoroallylium salt of formula C of claim 1 wherein R is 5 、R 6 、R 7 、R 8 、R 9 And R 10 Independently F, cl, br, I, C 1 -C 20 Alkyl of (C) 3 -C 20 Cycloalkyl of, C 6 -C 20 Aryl of (C) 2 -C 20 Alkynyl of (A), C 1 -C 20 By one or more R 1a Substituted C 1 -C 20 By one or more R 1b Substituted C 3 -C 20 By one or more R 1c Substituted C 6 -C 20 Aryl of (a), one or more R 1d SubstitutionC of (A) 2 -C 20 By one or more R 1e Substituted C 1 -C 20 A heteroalkyl group of (a); said C 1 -C 20 The heteroatom or heteroatom group of the heteroalkyl group of (a) is selected from C (= O), S (= O) 2 、SO 2 NR 1’ R 2’ 、O、N、Si、P、P(＝O)、PO(OR 3’ ) 2 、PS(OR 3’ ) 2 、B(R 4’ ) 2 And B (OR) 4’ ) 2 The number of the hetero atoms and hetero atom groups is 1 or more;
the R is 1a 、R 1b 、R 1c 、R 1d And R 1e Independently F, cl, br, I, N 3 、C 1 -C 20 Alkyl group of (1).
3. The 3,3-difluoroallylium salt of formula C of claim 1 wherein the 3,3-difluoroallylium salt of formula C satisfies one or more of the following conditions:
(1) X is an organic or inorganic anion, for example trifluoromethanesulfonate anion, fluoroborate anion, hexafluorophosphate anion, hexafluoroantimonate anion, p-toluenesulfonate anion, fluoride anion, chloride anion, bromide anion, iodide anion;
(2) Said C 1 -C 20 Alkyl of (3), substituted C 1 -C 20 C in alkyl of (A) 1 -C 20 Is independently C 1 -C 10 Alkyl of (2), as well as C 1 -C 6 Also such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl;
(3) Said C 1 -C 20 Heteroalkyl of (a), substituted C 1 -C 20 C in heteroalkyl of (2) 1 -C 20 Is independently-C (= O) O-hybridized C 1 -C 20 Alkyl groups of (a); for example-C (= O) OMe;
(4) Said C 6 -C 20 Aryl of (a), substituted C 6 -C 20 In the aryl radical of (1)C 6 -C 20 Aryl of (a) is independently phenyl;
(5) Said R 1 And R 4 Together with the attached Z form: 5-20 membered heterocycloalkyl of the substituted 5-20 membered heterocycloalkyl is independently 5-10 membered heterocycloalkyl, e.g.
Figure FDA0003821643360000021
(6) Said R 1 And R 4 Together with the attached Z form: 5-20 membered heteroaryl of 5-20 membered heteroaryl, substituted 5-20 membered heteroaryl is independently 5-10 membered heteroaryl, e.g. benzothiophene
Figure FDA0003821643360000022
(7) Said C 3 -C 20 Cycloalkyl of (a) is independently cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl;
(8) Said C 2 -C 20 Alkynyl of (2), substituted C 2 -C 20 C in alkynyl of (A) 2 -C 20 Alkynyl of (a) is independently C 2 -C 10 Alkynyl, as another example, C 2 -C 6 Alkynyl radicals of (1) also as
Figure FDA0003821643360000023
4. The 3,3-difluoroallylium salt of formula C of claim 1 wherein the 3,3-difluoroallylium salt of formula C satisfies one or more of the following conditions:
(1) Said C 1 -C 20 Alkyl of (3), substituted C 1 -C 20 C in alkyl of (A) 1 -C 20 Is independently n-hexyl;
(2) Said C 1 -C 20 Heteroalkyl of (2), substituted C 1 -C 20 C in heteroalkyl of (2) 1 -C 20 Is independently of the heteroalkyl group ofis-C (= O) O-or-O-hybridized C 1 -C 20 Alkyl groups of (A), e.g. -C (= O) OEt, -OCH 3 ；
(3) Said C 2 -C 20 Alkenyl of, substituted C 2 -C 20 C in alkenyl of (A) 2 -C 20 Is independently C 2 -C 10 Alkenyl radicals, as well as C 2 -C 6 Alkenyl radicals as also described
Figure FDA0003821643360000024
(4) The R is 4 Independently is C 1 -C 20 Alkyl of (3), preferably C 1 -C 6 Alkyl groups of (a), such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl;
(5) X is an organic or inorganic anion, for example the tetraphenylborate anion.
5. The 3,3-difluoroallylic onium salt of formula C of claim 3 or 4, wherein the 3,3-difluoroallylic onium salt of formula C meets one or more of the following conditions:
(1)R 1 、R 2 、R 3 and R 4 Independently H, F, cl, br, me, et, phenyl, tolyl, methoxyphenyl, bromophenyl, tri (methyl) phenyl, tri (isopropyl) phenyl, phenylethylene, -C (= O) OMe,
Figure FDA0003821643360000031
Figure FDA0003821643360000032
(2) Said R 1 And R 4 Together with the attached Z form:
Figure FDA0003821643360000033
Figure FDA0003821643360000034
alkyl is independently said C 1 -C 20 By one or more R 5 Substituted C 1 -C 20 Alkyl groups of (a); for example
Figure FDA0003821643360000035
6. The 3,3-difluoroallylium salt of formula C of claim 3 or 4 wherein the 3,3-difluoroallylium salt of formula C meets one or more of the following conditions:
(1) The R is 1 、R 2 、R 3 And R 4 Independently is tert-butylphenyl, n-hexyl,
Figure FDA0003821643360000036
(2) The R is 4 Independently Me or Et;
(3) The R is 1 And R 4 One of which is Me or Et and the other is phenyl, tolyl, methoxyphenyl, bromophenyl, tri (methyl) phenyl, tri (isopropyl) phenyl, or phenylethylene.
7. The 3,3-difluoroallylic onium salt of formula C of claim 1, wherein the 3,3-difluoroallylic onium salt of formula C is any of the following structures:
Figure FDA0003821643360000041
Figure FDA0003821643360000051
wherein X is as defined above; x is F, cl, br, BF 4 、OTf、BPh 4 、PF 6 、TeF 6 Or SbF 6 TIPP is tri (isopropyl) phenyl, mes is 2,4,6-trimethylphenyl, tol is tolyl, and Alkyl is independently said C 1 -C 20 By one or more R 5 Substituted C 1 -C 20 Alkyl groups of (a); ar is independently said C 6 -C 20 Aryl of (a) by one or more R 7 Substituted C 6 -C 20 Aryl group of (1).
8. The 3,3-difluoroallylium salt of formula C of claim 1 wherein 3,3-difluoroallylium salt of formula C is any of the following compounds:
Figure FDA0003821643360000061
Figure FDA0003821643360000071
9. a process for the preparation of 3,3-difluoroallylium salts of formula C as claimed in any of claims 1 to 8 comprising the steps of:
in an organic solvent, carrying out alkylation reaction on the compound shown in the formula D and an alkylating reagent to obtain a 3,3-difluoroallylonium salt compound shown in the formula C; the alkylating agent is R 4 X and/or R 4 Systems of I with AgX or R 4 3 OBF 4 ；
Figure FDA0003821643360000072
Wherein Z, X, R 1 、R 2 、R 3 And R 4 As defined in any one of claims 1 to 8.
10. The method of claim 9 for the preparation of 3,3-difluoroallylium salts of formula C wherein one or more of the following conditions are met:
(1) The organic solvent is aprotic solvent such as DCM, THF, DMF, DMSO;
(2) The molar ratio of the compound represented by formula D to the alkylating agent is 1.9 to 1.5, such as 1:1, 1.15;
(3) The alkylation reaction is carried out under argon or nitrogen;
(4) The alkylation reaction is carried out at a temperature of from 0 ℃ to 140 ℃, for example from 10 to 30 ℃.
11. The method of claim 9 for the preparation of 3,3-difluoroallylium salt of formula C, further comprising the preparation of the compound of formula D, comprising the steps of:
in an organic solvent, carrying out a substitution reaction shown as the following formula on a compound shown as a formula A and a compound shown as a formula B to obtain a compound shown as a formula D;
Figure FDA0003821643360000073
of these, Z, R 1 、R 2 And R 3 Is as defined in claim 9;
X 1 is F, cl or Br; m 1 Is an alkali metal.
12. A process for the preparation of 3,3-difluoroallylium salts of formula C as claimed in claim 11 which satisfies one or more of the following conditions:
(1)M 1 is Na, K or Li;
(2) The organic solvent is an aprotic solvent, such as one or more of dioxane, THF, DMF and DMSO;
(3) The molar ratio of the compound shown in the formula A to the compound shown in the formula B is 1:1-1:3, such as 1.2, 1.25 and 1:2;
(4) The substitution reaction is carried out under argon or nitrogen;
(5) The substitution reaction is carried out at room temperature to 140 ℃, preferably 50 ℃ to 140 ℃, for example 100 ± 10 ℃.
13. Use of 3,3-difluoroallylium salts of formula C as claimed in any of claims 1 to 8 as a reagent for α, α -geminal difluoroallylation.
14. The use of 3,3-difluoroallylium salts of formula C as an α, α -geminal difluoroallylation reagent according to claim 13, comprising the steps of:
in a solvent, carrying out coupling reaction on 3,3-difluoroallylonium salt compounds shown in a formula C and a zinc reagent shown in the specification to obtain alpha, alpha-gem-difluoroallylic compounds shown in a formula E;
Figure FDA0003821643360000081
of these, Z, X, R 1 、R 2 、R 3 And R 4 As defined in any one of claims 1 to 8;
[C]by Csp1, csp2 or Csp3 with [ Zn ]]A connected portion; [ Zn ]]Is represented by ZnX 2 、Zn·LiX 2 、ZnX 2 ·LiX 2 ；X 2 Independently bromine or chlorine;
examples of [ Zn ] include ZnBr, znCl, zn. LiCl, znCl. LiCl, and ZnBr. LiCl.
15. Use of a compound of the formula 3,3-difluoroallylium salts of formula C as claimed in claim 13 or 14 as an α, α -geminal difluoroallylation reagent, characterized in that it satisfies one or more of the following conditions:
(1) The molar ratio of 3,3-difluoroallylonium salt compounds shown in the formula C to the zinc reagent is 1:1 to 1.5; e.g. 1.1, 1.2, 1;
(2) The coupling reaction is carried out in the presence of a catalyst, wherein the catalyst is CuBr; the molar ratio of the catalyst to the 3,3-difluoroallylonium salt compound shown in the formula C is 0.2 to 0.005; e.g., 0.01, 0.025, 0.05, 0.1;
(3) The temperature of the coupling reaction is-78 to 35 ℃, for example, the reaction is carried out at room temperature;
(4) The solvent is an ether solvent; the ether solvent is tetrahydrofuran;
(5) The zinc reagent and the corresponding alpha-geminal difluoroallyl compound shown as the formula E are any one group as follows:
Figure FDA0003821643360000082
Figure FDA0003821643360000091
Figure FDA0003821643360000101
Figure FDA0003821643360000111
Figure FDA0003821643360000121
Figure FDA0003821643360000131
Figure FDA0003821643360000141
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