CN115252912A - Heparin sodium modified TPU anticoagulant medical catheter and preparation method thereof - Google Patents
Heparin sodium modified TPU anticoagulant medical catheter and preparation method thereof Download PDFInfo
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- CN115252912A CN115252912A CN202210881340.4A CN202210881340A CN115252912A CN 115252912 A CN115252912 A CN 115252912A CN 202210881340 A CN202210881340 A CN 202210881340A CN 115252912 A CN115252912 A CN 115252912A
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- tpu
- heparin
- heparin sodium
- medical catheter
- sodium
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- 229920000669 heparin Polymers 0.000 title claims abstract description 41
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 title claims abstract description 28
- 229960001008 heparin sodium Drugs 0.000 title claims abstract description 23
- 239000003146 anticoagulant agent Substances 0.000 title claims abstract description 18
- 229940127219 anticoagulant drug Drugs 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 31
- 238000002156 mixing Methods 0.000 claims abstract description 14
- 239000003054 catalyst Substances 0.000 claims abstract description 12
- 229920005862 polyol Polymers 0.000 claims abstract description 12
- 150000003077 polyols Chemical class 0.000 claims abstract description 12
- 239000004970 Chain extender Substances 0.000 claims abstract description 10
- 125000005442 diisocyanate group Chemical group 0.000 claims abstract description 10
- -1 polypropylene Polymers 0.000 claims abstract description 5
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- 229920005906 polyester polyol Polymers 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 238000000520 microinjection Methods 0.000 claims description 5
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- SBJCUZQNHOLYMD-UHFFFAOYSA-N 1,5-Naphthalene diisocyanate Chemical compound C1=CC=C2C(N=C=O)=CC=CC2=C1N=C=O SBJCUZQNHOLYMD-UHFFFAOYSA-N 0.000 claims description 2
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 claims description 2
- 239000005058 Isophorone diisocyanate Substances 0.000 claims description 2
- 239000005062 Polybutadiene Substances 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920002857 polybutadiene Polymers 0.000 claims description 2
- 229920001610 polycaprolactone Polymers 0.000 claims description 2
- 239000004632 polycaprolactone Substances 0.000 claims description 2
- 239000004417 polycarbonate Substances 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 229920000909 polytetrahydrofuran Polymers 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- 229910052708 sodium Inorganic materials 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 abstract description 3
- 238000001125 extrusion Methods 0.000 abstract description 3
- 229920001155 polypropylene Polymers 0.000 abstract description 3
- 230000002429 anti-coagulating effect Effects 0.000 abstract description 2
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 28
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 28
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 11
- 229960002897 heparin Drugs 0.000 description 11
- 230000004048 modification Effects 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
- 230000010100 anticoagulation Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 1
- 239000002506 anticoagulant protein Substances 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/043—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a heparin sodium modified TPU anticoagulant medical catheter and a preparation method thereof, wherein the catheter comprises the following components in parts by mass: 25-50% of diisocyanate, 20-70% of polyol, 5-20% of polypropylene, 1-10% of chain extender, 5-10% of heparin sodium and 0-1% of catalyst, and the single-screw extruder is adopted for blending extrusion processing, and the effective dispersion of the heparin sodium in the material is realized through the compatibility of a secondary solution, so that the mechanical property of the TPU material of the catheter main body is not influenced while the anticoagulant effect is exerted on the inner surface of the catheter, and the TPU material has the characteristics of good processing flowability, suitability for extrusion molding and the like.
Description
Technical Field
The invention relates to a heparin sodium modified TPU (thermoplastic polyurethane) anticoagulant medical catheter and a preparation method thereof, belonging to the field of medical polymer materials and products.
Background
TPU materials have gradually replaced traditional plastics such as PE, PVC and the like to become one of the mainstream materials in the field of medical catheters due to excellent processability, mechanical properties and elasticity. However, aiming at the anticoagulation requirement of the medical blood vessel, the modification, processing technology, formula and the like of the pure TPU material are not mature and reliable enough, and the blood coagulation and the thrombus are easy to occur.
Meanwhile, heparin and derivatives thereof have been studied and used as mature anticoagulants for many years, so that modification of TPU with heparin and derivatives thereof to prepare anticoagulant catheters naturally becomes a technological means which is easy for technicians in the field to think, but reports of similar technical routes in the publications are rare, because TPU has poor compatibility with heparin and derivatives thereof.
For example, chinese patent No. CN114588386A discloses an indwelling needle catheter and a manufacturing apparatus and method thereof, wherein a heparin layer is provided on the inner surface of the indwelling needle catheter body, and a method of plasma modification, heparin atomization and "plasma gas" delivery are performed on the inner surface of the tube body to attach heparin to the inner surface of the tube body, which is complicated, high in expected cost and unsatisfactory in expected utility. If the material can be directly added with heparin through blending modification during the processing and forming of TPU, the method is undoubtedly simple and efficient, but the heparin and the derivative thereof are water-soluble polymers and have very poor compatibility with TPU materials, and the material matrix is difficult to uniformly disperse when the heparin and the derivative thereof are directly added. In addition, since anticoagulant protein must interact with the heparin with the chain segments fully extended to exert the efficacy, otherwise, not only the effective anticoagulant effect cannot be realized, but also the mechanical property and the processability of the TPU material are seriously influenced.
Disclosure of Invention
The invention aims to solve the technical problem that heparin and derivatives thereof cannot be effectively added into a TPU catheter to realize anticoagulation.
In order to achieve the above objects, in a first aspect, the present invention provides a sodium heparin modified TPU anticoagulant medical catheter, which comprises the following components:
further, the polyol is one or more of polyester polyol, polycaprolactone polyol, polycarbonate polyol, polybutadiene polyol and polytetramethylene ether glycol; the number average molecular weight of the polymer polyol is 1000-5000.
Further, the diisocyanate is one or more of 4,4' -diphenylmethane diisocyanate, 1, 5-naphthalene diisocyanate, and isophorone diisocyanate.
Further, the chain extender is a small molecule diol containing 2 to 10 carbon atoms.
Further, the catalyst is an organic bismuth catalyst.
In a second aspect, the invention provides a preparation method of a heparin sodium modified TPU anticoagulant medical catheter, which comprises the following steps: (1) Adding polyester polyol, diisocyanate and a chain extender into a reaction kettle, stirring for 30-60 minutes at the temperature of 85-105 ℃ to form a pre-polymerized material, and injecting the pre-polymerized material into a single-screw extruder through a mixing and batching system;
(2) Simultaneously adding a catalyst into a feeding port of the single-screw extruder through a micro-injection pump;
(3) Preparing a special side feeding material: 1. preparing a saturated aqueous solution of heparin sodium; 2. in aqueous heparin sodium solution according to the ratio of 1:0.5-5, adding a TPU good solvent which is mutually soluble with water to obtain a heparin sodium secondary solution containing two solvents; 3. mixing a heparin sodium secondary solvent according to a volume ratio of 1:0.5-2, and the TPU granules are blended and stirred to fully infiltrate the solution and the TPU granules to obtain a special side-feeding material;
(4) Feeding the special side-feeding material with corresponding weight through a side-feeding port of the single-screw extruder.
Further, the good solvent for the water-miscible TPU in the step (3) comprises: one or more of dioxane, acetone, butanone and Dimethylformamide (DMF).
Compared with the prior art, the invention has the following beneficial effects:
the secondary solution enables the heparin sodium macromolecular chain to be fully stretched and not to agglomerate in the TPU matrix, so that the anticoagulation effect is effectively exerted, and meanwhile, the excellent mechanical property of the TPU material of the catheter main body is not influenced, and the catheter main body has the characteristics of good processing fluidity, suitability for extrusion molding and the like; the tensile strength of the obtained product can reach 35-60MPa, the elongation at break can reach 500% -700%, the hardness range is 65-75A, and the product has good biocompatibility and obvious anticoagulation effect.
Detailed Description
The present invention will now be described in further detail with reference to examples, but the present invention is not limited to the following examples, and any modifications made thereto will fall within the scope of the present invention.
Example 1:
a heparin sodium modified TPU anticoagulant medical catheter comprises the following components:
| component name | Mass percent (%) |
| Diisocyanate | 45％ |
| Polyhydric alcohols | 40％ |
| Polypropylene | 5％ |
| Chain extender | 5％ |
| Heparin sodium | 5％ |
| Catalyst and process for preparing same | 0.5％ |
The extruded catheter was processed as follows: (1) Adding polyester polyol, diisocyanate and a chain extender into a reaction kettle, stirring at 85 ℃ for 60 minutes, and injecting into a single-screw extruder through a mixing and batching system; (2) Simultaneously adding a catalyst into a feeding port of the single-screw extruder through a micro-injection pump; (3) preparing a special side-feeding material: preparing a sodium heparin aqueous solution according to the proportion of 1:1, adding dioxane, and mixing a secondary solvent according to a volume ratio of 1:1, blending and stirring with TPU granules to fully infiltrate the solution and the TPU granules, and no obvious free liquid drips on the whole material; (4) Feeding the special side-feeding material with corresponding weight through a side-feeding port of the single-screw extruder.
Example 2:
a heparin sodium modified TPU anticoagulant medical catheter comprises the following components:
| component name | Mass percent (%) |
| Diisocyanate | 30％ |
| Polyhydric alcohols | 40％ |
| Polypropylene | 20％ |
| Chain extender | 10％ |
| Heparin sodium | 10％ |
| Catalyst and process for preparing same | 0.5％ |
The extruded catheter was processed as follows: (1) Adding polyester polyol, diisocyanate and a chain extender into a reaction kettle, stirring at 85 ℃ for 60 minutes, and injecting into a single-screw extruder through a mixing and batching system; (2) Simultaneously adding a catalyst into a feeding port of the single-screw extruder through a micro-injection pump; (3) preparing a special side-feeding material: preparing a sodium heparin aqueous solution according to the proportion of 1:0.5 adding Dimethylformamide (DMF), and mixing the secondary solvent according to a volume ratio of 1:1, blending and stirring with TPU granules to fully infiltrate the solution and the TPU granules, and no obvious free liquid drips on the whole material; (4) Feeding the special side-feeding material with corresponding weight through a side-feeding port of the single-screw extruder.
Example 3:
a heparin sodium modified TPU anticoagulant medical catheter comprises the following components:
the extruded conduit was processed as follows: (1) Adding polyester polyol, diisocyanate and a chain extender into a reaction kettle, stirring at 85 ℃ for 60 minutes, and injecting into a single-screw extruder through a mixing and batching system; (2) Simultaneously adding a catalyst into a feeding port of the single-screw extruder through a micro-injection pump; (3) preparing a special side-feeding material: preparing a sodium heparin aqueous solution according to the proportion of 1:2, adding acetone, and mixing the secondary solvent according to a volume ratio of 1:0.5 and TPU granules are blended and stirred, so that the solution and the TPU granules are fully infiltrated, and no obvious free liquid drops on the whole material; (4) Feeding the special side-feeding material with corresponding weight through a side-feeding port of the single-screw extruder.
The foregoing is considered as illustrative of the principles of the invention and is not intended to limit the invention in any way. The undescribed parts are by no means to be considered as employing the solutions known in the art, and any simple modification, equivalent change and modification made to the above embodiments in accordance with the technical spirit of the present invention are still within the scope of the technical solution of the present invention.
Claims (7)
1. The heparin sodium modified TPU anticoagulant medical catheter is characterized by comprising the following components:
2. the heparin sodium modified TPU anticoagulant medical catheter of claim 1, wherein the polyol is one or more of five polymer polyols, polyester polyol, polycaprolactone polyol, polycarbonate polyol, polybutadiene polyol and polytetramethylene ether glycol; the number average molecular weight of the polymer polyol is 1000-5000.
3. The sodium heparin-modified TPU anticoagulant medical catheter of claim 1, wherein the diisocyanate is one or more of 4,4' -diphenylmethane diisocyanate, 1, 5-naphthalene diisocyanate, and isophorone diisocyanate.
4. The sodium heparin-modified TPU anticoagulant medical catheter of claim 1, wherein the chain extender is a small molecule diol containing 2-10 carbon atoms.
5. The heparin sodium modified TPU anticoagulant medical catheter of claim 1, wherein the catalyst is an organobismuth catalyst.
6. A preparation method of a heparin sodium modified TPU anticoagulant medical catheter is characterized by comprising the following steps:
(1) Adding polyester polyol, diisocyanate and a chain extender into a reaction kettle, stirring for 30-60 minutes at 85-105 ℃ to form a pre-polymerized material, and injecting the pre-polymerized material into a single-screw extruder through a mixing and batching system;
(2) Adding a catalyst into a feeding port of the single-screw extruder through a micro-injection pump while injecting the pre-polymerization material;
(3) The preparation method of the special side-feeding material comprises the following steps: (31) preparing a saturated aqueous solution of heparin sodium; (32) dissolving in a sodium heparin aqueous solution according to the ratio of 1:0.5-5, adding a TPU good solvent mutually soluble with water to obtain a heparin sodium secondary solution containing two solvents; (33) mixing the heparin sodium secondary solution according to the volume ratio of 1:0.5-2, and TPU granules, and fully infiltrating the heparin sodium secondary solution and the TPU granules to obtain a side-feeding special material;
(4) Feeding the special side-feeding material with corresponding parts through a side-feeding port of the single-screw extruder.
7. The method for preparing the sodium heparin-modified TPU anticoagulant medical catheter as claimed in claim 6, wherein the good solvent of TPU miscible with water in step (33) comprises: one or more of dioxane, acetone, butanone and Dimethylformamide (DMF).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210881340.4A CN115252912B (en) | 2022-07-22 | 2022-07-22 | Heparin sodium modified TPU anticoagulation medical catheter and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210881340.4A CN115252912B (en) | 2022-07-22 | 2022-07-22 | Heparin sodium modified TPU anticoagulation medical catheter and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN115252912A true CN115252912A (en) | 2022-11-01 |
| CN115252912B CN115252912B (en) | 2024-03-22 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03223377A (en) * | 1989-11-30 | 1991-10-02 | Terumo Corp | Functional group-containing substrate, preparation of the same, and medical material and equipment using the substrate |
| CN102718977A (en) * | 2012-07-04 | 2012-10-10 | 南京师范大学 | Heparin sodium-loaded polyurethane micro nanometer particle solution and preparation method and application thereof |
| CN103709919A (en) * | 2013-12-19 | 2014-04-09 | 四川大学 | Heparinized polyurethane coating liquid and preparation method thereof |
| CN114163806A (en) * | 2021-11-29 | 2022-03-11 | 浙江大学台州研究院 | Antibacterial polysaccharide outer surface modified TPU medical catheter and preparation method thereof |
| CN114163805A (en) * | 2021-11-29 | 2022-03-11 | 浙江大学台州研究院 | Alginate antibacterial outer surface modified TPU extruded wire and preparation method thereof |
-
2022
- 2022-07-22 CN CN202210881340.4A patent/CN115252912B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03223377A (en) * | 1989-11-30 | 1991-10-02 | Terumo Corp | Functional group-containing substrate, preparation of the same, and medical material and equipment using the substrate |
| CN102718977A (en) * | 2012-07-04 | 2012-10-10 | 南京师范大学 | Heparin sodium-loaded polyurethane micro nanometer particle solution and preparation method and application thereof |
| CN103709919A (en) * | 2013-12-19 | 2014-04-09 | 四川大学 | Heparinized polyurethane coating liquid and preparation method thereof |
| CN114163806A (en) * | 2021-11-29 | 2022-03-11 | 浙江大学台州研究院 | Antibacterial polysaccharide outer surface modified TPU medical catheter and preparation method thereof |
| CN114163805A (en) * | 2021-11-29 | 2022-03-11 | 浙江大学台州研究院 | Alginate antibacterial outer surface modified TPU extruded wire and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN115252912B (en) | 2024-03-22 |
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