CN115252039B - Vascular closure device and method - Google Patents

Vascular closure device and method Download PDF

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Publication number
CN115252039B
CN115252039B CN202211186926.5A CN202211186926A CN115252039B CN 115252039 B CN115252039 B CN 115252039B CN 202211186926 A CN202211186926 A CN 202211186926A CN 115252039 B CN115252039 B CN 115252039B
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China
Prior art keywords
channel
outer tube
cavity
blood vessel
transmission
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CN202211186926.5A
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Chinese (zh)
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CN115252039A (en
Inventor
刘文菁
刘振兴
许自远
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Suzhou Meichuang Medical Technology Co ltd
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Suzhou Meichuang Medical Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027Type of occlusion
    • A61B17/12031Type of occlusion complete occlusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12159Solid plugs; being solid before insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices

Abstract

The embodiment of the invention provides a vascular closure device and a vascular closure method, and relates to the field of medical instruments. Aims to solve the problem of poor hemostatic effect of the existing vascular wound. The vascular closure device comprises an instrument handle, a multi-cavity outer tube and a multi-cavity inner tube; the multi-cavity inner tube is arranged in the multi-cavity outer tube, and a pipeline cavity for accommodating the sealing gasket and the plugging sponge is formed between the far end of the multi-cavity inner tube and the far end of the multi-cavity outer tube; the multi-cavity inner tube is provided with a connecting line channel and an injection channel, the connecting line channel is used for penetrating through a connecting line, and the injection channel is used for injecting sealed collagen into a vascular wound. The vascular closure method is performed using the vascular closure device described above. Carry out sealed the covering of seal gasket to blood vessel wound bottom, the cooperation shutoff sponge carries out the pre-plugging to the blood vessel wound, and the outside of blood vessel wound adopts sealed collagen to seal, and multiple sealed cooperation realizes the hemostatic effect to the blood vessel wound, and is sealed effectual, easy operation.

Description

Vascular closure device and method
Technical Field
The invention relates to the field of medical instruments, in particular to a vascular closure device and a vascular closure method.
Background
The operation is performed in a vascular intervention mode, so that the advantages of small wound and low infection risk are achieved. However, hemostasis of the puncture site of the blood vessel remains a clinical challenge, especially for some surgeries requiring large-caliber vascular access wounds. The traditional manual pressing hemostasis mode has the defects of long hemostasis time, need of strict braking of a patient, easiness in hematoma formation, discomfort of the patient, vagus nerve reflex, occupation of time of medical care personnel and the like; with the development of vascular interventional therapy, a thicker catheter sheath and anticoagulant drugs are often needed, and the compression time for hemostasis is longer, so that the problem is more obvious. The blood vessel wound is sutured and stopped bleeding by inserting the suture needle, the blood vessel wound is sutured and stopped bleeding by utilizing the suture, the hemostasis time is reduced, but the blood vessel of a small wound can be sutured, when a large wound is sutured, a plurality of instruments are probably needed to be sutured, wrinkles are easily generated at the suture wound, the blood vessel passage is influenced, and when a patient is cured in blood vessels, the suturing effect is poor.
Disclosure of Invention
The invention aims to provide a vascular closure device and a vascular closure method, which can solve the problem of poor hemostatic effect of the existing vascular wound.
Embodiments of the invention may be implemented as follows:
embodiments of the present invention provide a vascular closure device comprising an instrument handle, a multi-lumen outer tube, and a multi-lumen inner tube;
the proximal end of the multi-cavity outer tube is connected with the distal end of the instrument handle, and the distal end of the multi-cavity outer tube is used for extending into a blood vessel from a blood vessel wound;
the multi-cavity inner tube is arranged in the multi-cavity outer tube, and a pipeline cavity for accommodating a sealing gasket and a plugging sponge is formed between the far end of the multi-cavity inner tube and the far end of the multi-cavity outer tube; the multi-cavity inner tube is used for moving relative to the multi-cavity outer tube under the condition that the multi-cavity outer tube moves to a preset position relative to the blood vessel wound so as to push the sealing gasket and the plugging sponge out of the pipeline cavity towards the far end, and therefore the sealing gasket and the plugging sponge are released;
the multi-cavity inner tube is provided with a connecting line channel and an injection channel, the connecting line channel is used for penetrating and connecting the sealing gasket and the plugging sponge, the connecting line is used for pulling the released sealing gasket and the plugging sponge so as to enable the sealing gasket to seal a blood vessel wound from the inner side of the blood vessel, and the plugging sponge is filled in the blood vessel wound; the injection channel is used for injecting sealing collagen to the vascular wound so that the sealing collagen covers the vascular wound and the blocking sponge in a sealing mode from the outside of the blood vessel.
In addition, the vascular closure device provided by the embodiment of the present invention may also have the following additional technical features:
optionally, the instrument handle comprises a handle sleeve, a drive conduit, a drive bolt, and a drive knob; the proximal end of the multi-cavity outer tube is connected with the distal end of the handle sleeve; the transmission pipeline is fixed in the handle sleeve, and the near end of the multi-cavity inner pipe is connected with the far end of the transmission pipeline; the transmission bolt is arranged at the near end of the handle sleeve, the transmission bolt is in threaded connection with the handle sleeve, and the near end of the transmission pipeline is connected with the transmission bolt; the transmission handle is arranged at the near end of the handle sleeve, the transmission handle is sleeved on the outer side of the transmission bolt, and the transmission handle is used for driving the transmission bolt to rotate relative to the handle sleeve under the action of external force so as to drive the transmission pipeline and the multi-cavity inner pipe to move in a reciprocating mode.
Optionally, the instrument handle further comprises a fixation nut; the fixing nut is arranged in the handle sleeve, the transmission bolt is arranged in the fixing nut, and the transmission bolt is in threaded connection with the fixing nut.
Optionally, the instrument handle further comprises a breakout component and an exit conduit; the branching part is provided with a transmission pipe passage and a transition passage, the lead-out wire pipe is arranged on the branching part, and the lead-out wire pipe is communicated with the transition passage; the branching component is fixed in the handle sleeve, and the transmission pipe passage is used for penetrating the transmission pipeline; transition passageway with the near-end intercommunication of connecting wire passageway, it wears to establish to draw forth the spool outside the handle cover, the connecting wire passageway transition passageway and it is used for jointly wearing to establish to draw forth the spool the connecting wire.
Optionally, an injection hole is formed in the rear end of the transmission handle, a collagen channel is formed in the transmission bolt, and the injection hole, the collagen channel, the transmission pipeline and the injection channel are sequentially communicated; the drive handle is used for being detachably connected with the injector.
Optionally, a blood flow channel is arranged between the outer wall and the inner wall of the multi-cavity outer tube, and a blood flow inlet communicated with the blood flow channel is arranged on the outer wall at the distal end of the multi-cavity outer tube; the blood flow inlet is used for supplying blood to the blood flow channel when the distal end of the multi-cavity outer tube is inserted into the blood vessel wound, or the blood flow inlet is used for stopping the blood from flowing into the blood flow channel when the multi-cavity outer tube moves to the preset position relative to the blood vessel wound.
Optionally, the vascular closure device further comprises a blood flow outlet channel and a luer fitting; the blood flow outlet channel is connected to the proximal end of the multi-lumen outer tube and is in communication with the blood flow channel, the blood flow outlet channel being adapted to be closed by the luer fitting when the multi-lumen outer tube is moved to the preset position.
Optionally, a guide wire channel is further arranged between the outer wall and the inner wall of the multi-cavity outer tube; the guide wire channel is used for being penetrated by a guide wire, and the guide wire is used for drawing the distal end of the multi-cavity outer tube to extend into the blood vessel from the blood vessel wound.
Optionally, the vascular closure device further comprises a guidewire tube and a hemostasis valve, the guidewire tube is connected to the proximal end of the multi-lumen outer tube, the guidewire tube is communicated with the guidewire channel, and the guidewire tube and the guidewire channel are used for commonly penetrating a guidewire for guiding; the hemostasis valve sets up on the guide wire pipe, the hemostasis valve is used for preventing blood from following the guide wire pipe flows out, just the hemostasis valve can pass the seal wire.
Embodiments of the present invention also provide a vascular closure method, implemented using a vascular closure device, the vascular closure method including the steps of:
drawing the distal end of the multi-cavity outer tube into the vascular wound, and stopping the multi-cavity outer tube after the multi-cavity outer tube moves to the preset position;
pushing the multi-cavity inner tube to push out the sealing gasket and the plugging sponge in the pipeline cavity;
pulling the connecting wire until the sealing gasket seals the vascular wound from the inner side of the blood vessel, wherein the plugging sponge is filled in the vascular wound;
injecting sealing collagen into the vascular wound through the injection channel so that the sealing collagen hermetically covers the vascular wound and the blocking sponge from the outside of the blood vessel.
The vascular closure device and method of the embodiments of the present invention have beneficial effects, for example, including:
the vascular closure device comprises an instrument handle, a multi-cavity outer tube and a multi-cavity inner tube; the proximal end of the multi-cavity outer tube is connected with the distal end of the instrument handle, and the distal end of the multi-cavity outer tube is used for extending into a blood vessel from a blood vessel wound; the multi-cavity inner tube is arranged in the multi-cavity outer tube, and a pipeline cavity for accommodating the sealing gasket and the plugging sponge is formed between the far end of the multi-cavity inner tube and the far end of the multi-cavity outer tube; the multi-cavity inner tube is used for moving relative to the multi-cavity outer tube under the condition that the multi-cavity outer tube moves to a preset position relative to the blood vessel wound so as to push the sealing gasket and the plugging sponge out of the pipeline cavity towards the far end, so that the sealing gasket and the plugging sponge are released; the multi-cavity inner tube is provided with a connecting line channel and an injection channel, the connecting line channel is used for penetrating and connecting a connecting line of the sealing gasket and the plugging sponge, and the connecting line is used for pulling the released sealing gasket and the plugging sponge so that the sealing gasket seals a blood vessel wound from the inner side of the blood vessel, and the plugging sponge is filled in the blood vessel wound; the injection channel is used for injecting sealing collagen to the vascular wound, so that the sealing collagen covers the vascular wound from the outside of the blood vessel in a sealing mode and the sponge is blocked.
The far end of the multi-cavity outer tube is pulled into the vascular wound, and the multi-cavity outer tube is stopped after being moved to a preset position; pushing the multi-cavity inner tube to push out the sealing gasket and the plugging sponge in the pipeline cavity; releasing the sealing gasket and the plugging sponge; pulling the connecting line until the sealing gasket seals the vascular wound from the inner side of the blood vessel, and filling the plugging sponge in the vascular wound; injecting sealing collagen into the vascular wound through the injection channel, so that the sealing collagen can seal and cover the vascular wound from the outer side of the blood vessel and can close the sponge. The hemostasis effect on the vascular wound is realized through multiple sealing coordination, the sealing effect is good, and the operation is simple.
The vascular closure method is implemented by adopting the vascular closure device, and the problem of poor hemostatic effect of the existing vascular wound can be solved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is an isometric view of a vascular closure device provided in accordance with an embodiment of the present invention;
FIG. 2 is a front view of a vascular closure device provided in accordance with an embodiment of the present invention;
FIG. 3 isbase:Sub>A cross-sectional view A-A of FIG. 2 according to an embodiment of the present invention;
FIG. 4 is an enlarged view of a portion of the first section of FIG. 3 in accordance with an embodiment of the present invention;
FIG. 5 is an enlarged view of a portion of the second section of FIG. 3 in accordance with an embodiment of the present invention;
FIG. 6 is a cross-sectional view of B-B of FIG. 2 according to an embodiment of the present invention;
FIG. 7 is a cross-sectional view of C-C of FIG. 2 according to an embodiment of the present invention;
FIG. 8 is a partial schematic structural view of a handle of an instrument provided in accordance with an embodiment of the present invention;
FIG. 9 is a schematic internal view of a portion of the structure of an instrument handle provided in accordance with an embodiment of the present invention;
FIG. 10 is a schematic diagram of a multiple seal for a vascular wound according to an embodiment of the present invention;
fig. 11 is a block diagram of the steps of a vessel closing method according to an embodiment of the present invention.
Icon: 10-a vascular closure device; 100-an instrument handle; 110-a handle cover; 120-a drive conduit; 130-drive bolt; 131-collagen channels; 140-a drive handle; 141-an injection port; 150-a retaining nut; 160-a holder; 170-front limit ring; 180-rear limit ring; 190-a splitter component; 191-a drive line channel; 192-a transition channel; 193-lead out spool; 200-a multi-lumen outer tube; 210-a conduit lumen; 220-a blood flow channel; 221-blood flow inlet; 230-a guide wire channel; 300-a multi-lumen inner tube; 310-connecting line channel; 320-an injection channel; 400-a syringe; 510-a haemostatic valve; 500-a wire guide tube; 600-a blood flow outlet channel; 700-a blood vessel; 710-a vascular wound; 800-sealing gasket; 810-plugging sponge; 820-sealing collagen; 900-connecting line.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. indicate an orientation or a positional relationship based on that shown in the drawings or that the product of the present invention is used as it is, this is only for convenience of description and simplification of the description, and it does not indicate or imply that the device or the element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention.
Furthermore, the appearances of the terms "first," "second," and the like, if any, are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.
It should be noted that the features of the embodiments of the present invention may be combined with each other without conflict.
The vascular closure device 10 provided in the present embodiment is described in detail below with reference to fig. 1 to 11.
Referring to fig. 1-10, an embodiment of the present invention provides a vascular closure device 10 including an instrument handle 100, a multi-lumen outer tube 200, and a multi-lumen inner tube 300; the proximal end of the multi-lumen outer tube 200 is connected to the distal end of the instrument handle 100, and the distal end of the multi-lumen outer tube 200 is used to extend from the vascular wound 710 into the blood vessel 700; the multi-cavity inner tube 300 is arranged in the multi-cavity outer tube 200, and a pipeline cavity 210 for accommodating a sealing gasket 800 and a plugging sponge 810 is formed between the distal end of the multi-cavity inner tube 300 and the distal end of the multi-cavity outer tube 200; the multi-lumen inner tube 300 is adapted to move relative to the multi-lumen outer tube 200 to push the sealing gasket 800 and the occlusion sponge 810 out of the lumen 210 distally, in case the multi-lumen outer tube 200 is moved to a predetermined position relative to the vascular wound 710, thereby releasing the sealing gasket 800 and the occlusion sponge 810; the multi-cavity inner tube 300 is provided with a connecting line channel 310 and an injection channel 320, the connecting line channel 310 is used for penetrating and connecting a connecting line 900 of a sealing gasket 800 and a sealing sponge 810, the connecting line 900 is used for pulling the released sealing gasket 800 and the sealing sponge 810 so that the sealing gasket 800 seals a blood vessel wound 710 from the inner side of the blood vessel 700, and the sealing sponge 810 is filled in the blood vessel wound 710; the injection channel 320 is used to inject the sealing collagen 820 into the blood vessel wound 710, so that the sealing collagen 820 is sealed from the outside of the blood vessel 700 to cover the blood vessel wound 710 and to block the sponge 810.
It should be noted that: as used herein, reference to "distal" refers to the end of the member that is distal to the medical operator during a surgical procedure, and "proximal" refers to the end of the member that is proximal to the medical operator during the surgical procedure. For example, the "distal end" of the multi-lumen outer tube 200 refers to the end of the multi-lumen outer tube 200 that is distal from the practitioner during the surgical procedure, i.e., the end that is proximal to the patient, and the proximal end of the multi-lumen tube refers to the end of the multi-lumen tube that is proximal to the practitioner during the surgical procedure, i.e., the end that is distal from the patient. To illustrate the relative positions in FIG. 2, the left end of the multi-lumen outer tube 200 is the distal end of the multi-lumen outer tube 200, and the right end of the multi-lumen outer tube 200 is the proximal end of the multi-lumen outer tube 200; the left end of the instrument handle 100 is the distal end of the instrument handle 100, the right end of the instrument handle 100 is the proximal end of the instrument handle 100, and the proximal end of the multilumen outer tube 200 is connected to the distal end of the instrument handle 100.
Referring to fig. 2, 3, 4 and 7, the multi-lumen inner tube 300 is placed within the multi-lumen outer tube 200, the multi-lumen inner tube 300 is shorter, e.g., 10mm shorter, than the multi-lumen outer tube 200, a 10mm long tunnel lumen 210 is formed between the distal end of the multi-lumen inner tube 300 and the distal end of the multi-lumen outer tube 200, the tunnel lumen 210 is used for placing a sealing gasket 800 and a sealing sponge 810, and the sealing gasket 800 is placed within the tunnel lumen 210 by bending. After the multi-cavity outer tube 200 extends into the blood vessel wound 710 and moves to the preset position, the multi-cavity inner tube 300 is pushed, the sealing gasket 800 and the plugging sponge 810 are pushed into the blood vessel 700, the sealing gasket 800 and the plugging sponge 810 are released, and the plugging sponge 810 expands.
Specifically, referring to fig. 10, the sealing gasket 800 is located at the distal end of the occlusion sponge 810, and after the connection wire 900 is pulled, the sealing gasket 800 covers the blood vessel wound 710 in a sealing manner from the bottom of the blood vessel wound 710, note that here, the sealing gasket 800 completely covers the bottom of the blood vessel wound 710 in a sealing manner, and sealing hemostasis can be achieved for blood vessel wounds 710 with different calibers by changing the size of the sealing gasket 800. The sealing sponge 810 is expanded to seal the vascular wound 710. The sealing gasket 800 is provided with a plugging sponge 810, the plugging sponge 810 can expand when contacting with blood, and pretension is realized on the blood vessel wound 710 after release.
Referring to fig. 2, 4 and 6, the multi-lumen inner tube 300 is provided with a connection line channel 310 and an injection channel 320, channel cavities are formed at distal ends of the connection line channel 310 and the injection channel 320, the connection line channel 310 is used for penetrating a connection line 900, one end of the connection line 900 is connected with the sealing patch and the sealing sponge 810 through the connection line channel 310, and the other end of the connection line 900 is fixed on the instrument handle 100. The released sealing gasket 800 and the sealing sponge 810 are tightened by operating the connecting line 900 to seal and seal the blood vessel wound 710.
Referring to fig. 6 and 10, the injection channel 320 of the multi-lumen inner tube 300 extending outward is used to inject the sealing collagen 820 inward, and the sealing collagen 820 is sealed and covers the occlusion sponge 810 and the vascular wound 710, so as to prevent the collagen from flowing into the blood vessel 700 and prevent the formation of thrombus.
The sealing gasket 800, the plugging sponge 810 and the sealing collagen 820 are all absorbable materials, can be absorbed within a period of time, and are good in biocompatibility and harmless to human bodies. The occlusion sponge 810 can be a collagen sponge, or a sponge made of other absorbable materials. The closing device consisting of the absorbable sealing gasket 800, the sealing sponge 810 and the sealing collagen 820 is used for carrying out multiple sealing on the vascular wound 710, so that a good hemostatic effect is achieved. Meanwhile, the arrangement of the multi-cavity outer tube 200 and the multi-cavity inner tube 300 has the advantages of integrated functions, simplified structure and simple operation, and is beneficial to improving the operation efficiency.
Referring to fig. 2, 3 and 5, in the present embodiment, the instrument handle 100 includes a handle sleeve 110, a transmission conduit 120, a transmission bolt 130 and a transmission knob 140; the proximal end of the multi-lumen outer tube 200 is connected to the distal end of the handle sleeve 110; the transmission pipe 120 is fixed in the handle sleeve 110, and the near end of the multi-cavity inner pipe 300 is connected with the far end of the transmission pipe 120; the transmission bolt 130 is arranged at the proximal end of the handle sleeve 110, the transmission bolt 130 is in threaded connection with the handle sleeve 110, and the proximal end of the transmission pipeline 120 is connected with the transmission bolt 130; the transmission handle 140 is disposed at the proximal end of the handle sleeve 110, the transmission handle 140 is disposed at the outer side of the transmission bolt 130, and the transmission handle 140 is used for driving the transmission bolt 130 to rotate relative to the handle sleeve 110 under the action of an external force, so as to drive the transmission pipe 120 and the multi-lumen inner tube 300 to reciprocate.
Specifically, the handle cover 110 includes an upper handle and a lower handle connected to each other, and a passage space is formed between the upper handle and the lower handle for installing components provided at the handle cover 110, which will be described later.
Referring to the relative positions in fig. 5, the driving handle 140, the driving bolt 130, the driving pipe 120 and the multi-cavity inner pipe 300 are sequentially connected from right to left, the driving bolt 130 is driven to rotate during the rotation of the driving handle 140 operated by external force, the driving bolt 130 moves linearly relative to the handle sleeve 110, and the driving pipe 120 and the multi-cavity inner pipe 300 move linearly and synchronously.
When the sealing gasket 800 and the plugging sponge 810 are released, the transmission handle 140 is rotated to enable the transmission bolt 130 to move forwards linearly, so that the transmission pipeline 120 is pushed to move forwards, and the multi-cavity inner tube 300 moves forwards; at this time, the sealing sponge 810 and the sealing gasket 800 placed in the lumen 210 of the tube move forward under the push of the multi-lumen inner tube 300, leaving the multi-lumen outer tube 200; at this time, the sealing gasket 800 is unfolded, the sealing gasket 800 and the sealing sponge 810 are released, the sealing gasket 800 is attached to the inner wall of the blood vessel 700 at the blood vessel wound 710 by tightening the connecting line 900, and the sealing sponge 810 seals the blood vessel wound 710, so that the releasing operation is completed.
Through knob propulsive mode, utilize helicitic texture, realize linear promotion, guarantee the position of apparatus in blood vessel 700, improved the stability in the surgical engineering. In other embodiments, other transmission means may be used, such as a push mechanism, a toggle transmission.
With continued reference to FIG. 5, in this embodiment, instrument handle 100 further includes a retaining nut 150; the fixing nut 150 is disposed in the handle grip 110, the driving bolt 130 is disposed in the fixing nut 150, and the driving bolt 130 is threadedly coupled to the fixing nut 150. The fixing nut 150 is fixed relative to the handle sleeve 110, and the driving bolt 130 moves linearly during the rotation relative to the fixing nut 150, so as to push the multi-lumen inner tube 300 to move forward.
With continued reference to fig. 5, in this embodiment, the instrument handle 100 further includes a front limiting ring 170 and a rear limiting ring 180, the front limiting ring 170 is disposed at the distal end of the transmission bolt 130, the rear limiting ring 180 is disposed at the rear end of the transmission bolt 130, the front limiting ring 170 and the rear limiting ring 180 are coaxially disposed, and the front limiting ring 170 and the rear limiting ring 180 are used to limit the transmission bolt 130 to perform linear movement together, so as to improve the movement precision.
Referring to fig. 5, 8 and 9, in this embodiment, the instrument handle 100 further includes a breakout component 190 and an exit conduit 193; the branching component 190 is provided with a transmission pipe channel 191 and a transition channel 192, the lead-out pipe 193 is arranged on the branching component 190, and the lead-out pipe 193 is communicated with the transition channel 192; the branching component 190 is fixed in the handle sleeve 110, and the transmission pipe channel 191 is used for penetrating the transmission pipe 120; the transition passage 192 communicates with the proximal end of the connecting wire passage 310, the outlet conduit 193 is disposed outside the handle cover 110, and the connecting wire passage 310, the transition passage 192, and the outlet conduit 193 are used to commonly pass through the connecting wire 900. Specifically, the outlet line pipe 193 is obliquely provided on the branching member 190.
One end of the connecting wire 900 is connected with the sealing patch and the sealing sponge 810 through the connecting wire channel 310, the transition channel 192 and the leading-out conduit 193, and the other end passes through the outside of the handle sleeve 110 and then is wound and fixed on the handle sleeve 110. The drive line channel 191 is used to support placement of the drive line 120.
Referring to fig. 5, 8 and 9, in the present embodiment, the instrument handle 100 further includes a fixer 160, the fixer 160 is disposed in the handle sleeve 110, the fixer 160 is provided with a fixing channel, the fixing channel is used for penetrating the transmission conduit 120, and the fixing channel is used for preventing the transmission conduit 120 from rotating circumferentially.
Referring to fig. 5, in the present embodiment, the injection hole 141 is formed at the rear end of the driving handle 140, the driving bolt 130 is provided with the collagen channel 131, and the injection hole 141, the collagen channel 131, the driving pipeline 120 and the injection channel 320 are sequentially communicated; the drive handle 140 is adapted to be removably coupled to the syringe 400.
The injection hole 141 is connected to the injection passage 320 through the collagen passage 131 and the transmission pipe 120 to form a passage. The collagen in the injector 400 can be injected through the injection hole 141 to the vascular wound 710, so as to achieve the effect of closing the blood vessel 700. The injector 400 and the apparatus handle 100 are in a split structure, so that the sealed collagen 820 can be packaged in a split manner, the collagen activity is prolonged, the collagen injection amount can be flexibly changed according to the condition of a patient, and a good clinical effect is achieved.
Referring to fig. 1, 2, 3 and 5, in particular, the vascular closure device 10 further comprises a syringe 400, the syringe 400 being detachably connected with the driving handle 140.
Referring to fig. 2, 4 and 6, in the present embodiment, a blood flow channel 220 is disposed between an outer wall and an inner wall of the multi-lumen outer tube 200, and a blood flow inlet 221 communicating with the blood flow channel 220 is disposed on an outer wall of a distal end of the multi-lumen outer tube 200; the blood flow inlet 221 is used to allow blood to flow into the blood flow passageway 220 if the distal end of the multi-lumen outer tube 200 is inserted into the vascular wound 710, or the blood flow inlet 221 is used to stop blood flow into the blood flow passageway 220 if the multi-lumen outer tube 200 is moved to a predetermined position relative to the vascular wound 710.
Specifically, the multi-lumen outer tube 200 is provided with a blood flow channel 220 and an inner channel, wherein the inner channel houses a multi-lumen inner tube 300. The distal side of the multi-lumen outer tube 200 is provided with a blood flow inlet 221 for determining the position of the vascular closure device 10 in the blood vessel 700.
The blood flow inlet 221 is used to provide blood flow into the blood flow passageway 220 in the event that the distal end of the multi-lumen outer tube 200 is inserted into the vascular wound 710, indicating that the distal end of the multi-lumen outer tube 200 is inserted into the vascular wound 710. Then, the multi-lumen outer tube 200 is moved backward until no blood flows into the blood inlet 221, which indicates that the multi-lumen outer tube 200 has moved to a predetermined position relative to the blood vessel opening 710, and at this time, the multi-lumen inner tube 300 can be pushed, so as to release the sealing gasket 800 and the occlusion sponge 810.
Therefore, the position of the blood inlet 221 is used to determine the position of the multi-lumen outer tube 200 and the positions of the release gasket 800 and the sealing sponge 810, and the position of the blood inlet 221 can achieve the above-mentioned effects.
Referring to fig. 1, 2 and 3, in the present embodiment, the vascular closure device 10 further includes a blood flow outlet channel 600 and a luer connector (not shown); a blood flow outlet channel 600 is connected to the proximal end of the multi-lumen outer tube 200, and the blood flow outlet channel 600 communicates with the blood flow channel 220, the blood flow outlet channel 600 being adapted to be closed by a luer fitting when the multi-lumen outer tube 200 is moved to a predetermined position.
After the blood flow inlet 221 has flowed into the blood, the multi-lumen outer tube 200 is moved until it reaches a predetermined position, and then the blood flow outlet channel 600 may be closed using a luer fitting.
Referring to fig. 2, 4 and 6, in the present embodiment, a guide wire channel 230 is further disposed between the outer wall and the inner wall of the multi-lumen outer tube 200; the guidewire channel 230 is used to thread a guidewire used to pull the distal end of the multilumen outer tube 200 from the vessel opening 710 into the vessel 700.
Specifically, the multi-lumen outer tube 200 is provided with a blood flow channel 220, a guidewire channel 230, and an inner channel within which the multi-lumen inner tube 300 is disposed. The guide wire channel 230 is used for passing through a guide wire, and the guide wire is used for guiding the moving track of the multi-lumen outer tube 200 in the body.
Referring again to fig. 1, 2 and 3, in the present embodiment, the blood vessel closing device 10 further includes a guidewire tube 500 and a hemostasis valve 510, the guidewire tube 500 is connected to the proximal end of the multilumen outer tube 200, the guidewire tube 500 is communicated with the guidewire channel 230, and the guidewire tube 500 and the guidewire channel 230 are used for commonly penetrating a guidewire for guiding; a hemostasis valve 510 is disposed on the guidewire tube 500, the hemostasis valve 510 being configured to prevent blood from flowing out of the guidewire tube 500, and the hemostasis valve 510 being capable of passing through the guidewire.
The guidewire tube 500 is used to exit the guidewire. After the multilumen outer tube 200 is inserted into the vascular opening, blood may exit through the guidewire channel 230 and the guidewire tube 500, which may be prevented from continuing out by the hemostasis valve 510.
According to the vascular closure device 10 provided in the present embodiment, the workflow of the vascular closure device 10 comprises:
the guide tube and the sheath tube are inserted through the guide wire, and the proper positions of the sheath tube and the guide tube are determined.
The guide tube is removed, the guide wire is inserted into the guide wire channel 230 of the multi-lumen outer tube 200 of the blood vessel closing device 10, and the multi-lumen outer tube 200 is inserted into the placed sheath tube through the guide wire, and the relative position and distance between the multi-lumen outer tube 200 and the sheath tube are determined as certain dimensions.
The side of the multi-cavity outer tube 200 is provided with a blood flow inlet 221, when the multi-cavity outer tube 200 is inserted into the sheath tube and enters the blood vessel 700, when the blood flow inlet 221 is positioned in the blood vessel 700, the blood flow flows out through the blood flow channel 220, and at the moment, the multi-cavity outer tube 200 is slowly drawn upwards until the blood flow stops; at this point, the blood flow inlet 221 is located just at the vascular wound 710, i.e., the multi-lumen outer tube 200 has been moved to the preset position, which is also the release position for which the vascular closure device 10 is designed. By rotating the driving handle 140 at the tail part, the multi-cavity inner tube 300 moves forward linearly, and the sealing gasket 800 and the plugging sponge 810 are pushed to enter the blood vessel 700.
The sheath and the transmission structure are pulled out of the blood vessel 700, the sealing gasket 800 is attached to the inner wall of the blood vessel 700 at the position of the blood vessel wound 710 through tensioning of the lead, the blood vessel wound 710 is sealed by the sealing sponge 810, the sealing collagen 820 is injected through the injector 400 to seal the outer wall of the blood vessel wound 710, a seal is formed on the blood vessel wound 710, and the collagen is pressed to wait for solidification. The connecting line 900 is cut off, the operation is completed, and the hemostasis of the vascular wound 710 is realized.
The present embodiment provides a vascular closure device 10 having at least the following advantages:
the multi-cavity outer tube 200 and the multi-cavity inner tube 300 are designed, and the functions are integrated, so that the size is ensured, and the number of instruments is reduced; sealing gasket 800 is used for sealing and covering the bottom of the blood vessel wound 710, the blood vessel wound 710 is pre-blocked by matching with blocking sponge 810, the upper part is sealed by sealing collagen 820, and the hemostasis effect on the blood vessel wound 710 is realized by multiple sealing and matching.
The blood flow inlet 221 is arranged, the release positions of the sealing gasket 800 and the plugging sponge 810 can be determined, the number of instruments is reduced, and position errors caused by instrument replacement are reduced.
The design of the rotary pushing structure of the transmission bolt 130 ensures stable release, ensures the position of the vascular closure device 10 in the blood vessel 700, and reduces the error of position change; the apparatus is operated by single rotation, and the learning cost is low.
The syringe 400 adopts a split design, so that the collagen activity is ensured, and the operation is convenient; the collagen injection amount is determined according to the customization of the patient and the operation condition.
Referring to fig. 11, embodiments of the present invention also provide a vascular closure method, implemented using the vascular closure device 10, comprising the steps of: step S1, the distal end of the multi-cavity outer tube 200 is pulled into the vascular wound 710, and the multi-cavity outer tube 200 is stopped after being moved to a preset position; step S2, pushing the multi-cavity inner tube 300 to push out the sealing gasket 800 and the plugging sponge 810 in the tube cavity 210; step S3, pulling the connecting line 900 until the sealing gasket 800 seals the blood vessel wound 710 from the inner side of the blood vessel 700, and filling the sealing sponge 810 in the blood vessel wound 710; step S4, injecting sealing collagen 820 into the blood vessel wound 710 through the injection channel 320, so that the sealing collagen 820 can cover the blood vessel wound 710 from the outside of the blood vessel 700 in a sealing manner and the sponge 810 can be blocked. Can improve the problem of poor hemostatic effect of the existing blood vessel wound 710.
The above description is only for the specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims (8)

1. A vascular closure device, comprising:
an instrument handle (100);
a multi-lumen outer tube (200), a proximal end of the multi-lumen outer tube (200) being connected to a distal end of the instrument handle (100), a distal end of the multi-lumen outer tube (200) being adapted to extend from a vascular wound (710) into a blood vessel (700);
and a multi-cavity inner tube (300), wherein the multi-cavity inner tube (300) is arranged in the multi-cavity outer tube (200), and a pipeline cavity (210) for accommodating a sealing gasket (800) and a plugging sponge (810) is formed between the distal end of the multi-cavity inner tube (300) and the distal end of the multi-cavity outer tube (200); the multi-cavity inner tube (300) is used for moving relative to the multi-cavity outer tube (200) under the condition that the multi-cavity outer tube (200) moves to a preset position relative to the blood vessel wound (710) so as to push the sealing gasket (800) and the blocking sponge (810) out of the duct cavity (210) towards the far end, and therefore the sealing gasket (800) and the blocking sponge (810) are released;
the multi-cavity inner tube (300) is provided with a connecting line channel (310) and an injection channel (320), the connecting line channel (310) is used for being provided with a connecting line (900) for connecting the sealing gasket (800) and the plugging sponge (810) in a penetrating mode, the connecting line (900) is used for pulling the released sealing gasket (800) and the plugging sponge (810) so that the sealing gasket (800) can seal a blood vessel wound (710) from the inner side of a blood vessel (700), and the plugging sponge (810) is filled in the blood vessel wound (710); the injection channel (320) is used for injecting sealing collagen (820) into the blood vessel wound (710) so that the sealing collagen (820) can be sealed to cover the blood vessel wound (710) and the blocking sponge (810) from the outside of the blood vessel (700);
a blood flow channel (220) is arranged between the outer wall and the inner wall of the multi-cavity outer tube (200), and a blood flow inlet (221) communicated with the blood flow channel (220) is arranged on the outer wall of the far end of the multi-cavity outer tube (200); the blood flow inlet (221) is for allowing blood to flow into the blood flow channel (220) if the distal end of the multilumen outer tube (200) is inserted into the vascular wound (710), or the blood flow inlet (221) is for stopping blood flow into the blood flow channel (220) if the multilumen outer tube (200) is moved to the preset position relative to the vascular wound (710).
2. The vascular closure device according to claim 1, wherein:
the instrument handle (100) comprises a handle sleeve (110), a transmission pipeline (120), a transmission bolt (130) and a transmission handle (140); the proximal end of the multi-cavity outer tube (200) is connected with the distal end of the handle sleeve (110); the transmission pipeline (120) is fixed in the handle sleeve (110), and the proximal end of the multi-cavity inner pipe (300) is connected with the distal end of the transmission pipeline (120); the transmission bolt (130) is arranged at the proximal end of the handle sleeve (110), the transmission bolt (130) is in threaded connection with the handle sleeve (110), and the proximal end of the transmission pipeline (120) is connected with the transmission bolt (130); the transmission handle (140) is arranged at the near end of the handle sleeve (110), the transmission handle (140) is sleeved on the outer side of the transmission bolt (130), and the transmission handle (140) is used for driving the transmission bolt (130) to rotate relative to the handle sleeve (110) under the action of external force so as to drive the transmission pipeline (120) and the multi-cavity inner pipe (300) to move in a reciprocating manner.
3. The vascular closure device according to claim 2, wherein:
the instrument handle (100) further comprises a fixation nut (150); the fixing nut (150) is arranged in the handle sleeve (110), the transmission bolt (130) is arranged in the fixing nut (150), and the transmission bolt (130) is in threaded connection with the fixing nut (150).
4. The vascular closure device according to claim 2, wherein:
the instrument handle (100) further comprises a wire branching component (190) and an outlet conduit (193); the branching component (190) is provided with a transmission pipe channel (191) and a transition channel (192), the outgoing pipe (193) is arranged on the branching component (190), and the outgoing pipe (193) is communicated with the transition channel (192); the branching component (190) is fixed in the handle sleeve (110), and the transmission pipe channel (191) is used for penetrating the transmission pipeline (120); transition passageway (192) with the near-end intercommunication of connecting wire passageway (310), it wears to establish to draw spool (193) outside handle cover (110), connecting wire passageway (310) transition passageway (192) and it is used for wearing to establish jointly to draw spool (193) connecting wire (900).
5. The vascular closure device according to claim 2, wherein:
an injection hole (141) is formed in the rear end of the transmission handle (140), a collagen channel (131) is formed in the transmission bolt (130), and the injection hole (141), the collagen channel (131), the transmission pipeline (120) and the injection channel (320) are communicated in sequence;
the drive handle (140) is adapted to removably couple with a syringe (400).
6. The vascular closure device according to any of claims 1-5, wherein:
the vascular closure device further comprises a blood flow outlet channel (600) and a luer fitting; the blood flow outlet channel (600) is connected to the proximal end of the multi-lumen outer tube (200), and the blood flow outlet channel (600) is communicated with the blood flow channel (220), the blood flow outlet channel (600) is used for being closed by the luer connector when the multi-lumen outer tube (200) is moved to the preset position.
7. The vascular closure device according to any of claims 1-5, wherein:
a guide wire channel (230) is also arranged between the outer wall and the inner wall of the multi-cavity outer tube (200); the guide wire channel (230) is used for arranging a guide wire in a penetrating way, and the guide wire is used for drawing the distal end of the multi-cavity outer tube (200) to extend from the blood vessel wound (710) into the blood vessel (700).
8. The vascular closure device according to claim 7, wherein:
the blood vessel closing device further comprises a guide wire tube (500) and a hemostasis valve (510), wherein the guide wire tube (500) is connected to the proximal end of the multilumen outer tube (200), the guide wire tube (500) is communicated with the guide wire channel (230), and the guide wire tube (500) and the guide wire channel (230) are used for commonly penetrating a guide wire for guiding; hemostasis valve (510) set up on the guide wire pipe (500), hemostasis valve (510) are used for preventing blood from following the flow of guide wire pipe (500), just hemostasis valve (510) can pass the guide wire.
CN202211186926.5A 2022-09-28 2022-09-28 Vascular closure device and method Active CN115252039B (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5282827A (en) * 1991-11-08 1994-02-01 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5531759A (en) * 1994-04-29 1996-07-02 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5649959A (en) * 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
CN1461204A (en) * 2000-08-02 2003-12-10 洛马林达大学医学中心 Method and apparatus for closing vascular puncture
CN107802311A (en) * 2017-11-20 2018-03-16 乐普(北京)医疗器械股份有限公司 A kind of Wholly-degradable vessel sealing structure

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8348971B2 (en) * 2004-08-27 2013-01-08 Accessclosure, Inc. Apparatus and methods for facilitating hemostasis within a vascular puncture
US8333787B2 (en) * 2007-12-31 2012-12-18 St. Jude Medical Puerto Rico Llc Vascular closure device having a flowable sealing material
US9131932B2 (en) * 2013-02-01 2015-09-15 St. Jude Medical Puerto Rico Llc Dual lumen carrier tube with retractable sleeve and methods
US9055933B2 (en) * 2013-03-12 2015-06-16 St. Jude Medical Puerto Rico Llc Large bore closure secondary hemostasis bioadhesive delivery systems and methods
US10639019B2 (en) * 2013-03-15 2020-05-05 Arrow International, Inc. Vascular closure devices and methods of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5282827A (en) * 1991-11-08 1994-02-01 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5531759A (en) * 1994-04-29 1996-07-02 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5649959A (en) * 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
CN1461204A (en) * 2000-08-02 2003-12-10 洛马林达大学医学中心 Method and apparatus for closing vascular puncture
CN107802311A (en) * 2017-11-20 2018-03-16 乐普(北京)医疗器械股份有限公司 A kind of Wholly-degradable vessel sealing structure

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