CN115251853A - Method, device and system for detecting position of microvascular and storage medium - Google Patents

Abstract

The invention discloses a method, device, system and storage medium for detecting the position of microvessels. The method includes: in response to detecting a trigger instruction, based on a first preset wavelength, controlling a light source in a signal acquisition array to irradiate a measured object, and Acquiring first reflected light signals respectively collected by at least two photodetectors in the signal collection array; wherein the light sources in the signal collection array are linearly arranged with each photodetector; for each photodetector, When the obtained first reflected light signal is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance; based on the target component distance and the detection depth corresponding to the photodetector, the blood vessel position of the microvessel is determined. The embodiment of the present invention solves the problem that the traditional blood vessel detection method cannot detect the position of the micro blood vessel, provides accurate position information of the micro blood vessel for medical operations, and further reduces the incidence of iatrogenic blood vessel injury.

Description

A microvessel position detection method, device, system and storage medium

technical field

The invention relates to the technical field of medical devices, in particular to a method, device, system and storage medium for detecting the position of microvessels.

Background technique

Iatrogenic vascular injury refers to accidental vascular injury during medical operations. Although large vessel injury has been greatly reduced with the popularization and improvement of vascular surgery knowledge, microvascular injury caused by misoperation is still unavoidable. Microvessels play an important role in blood supply to peripheral tissues. For example, damage to microvessels supplying nerves may lead to functional impairment of the nerves. Therefore, it is particularly important to determine whether there are microvessels and find out the specific location of microvessels during medical operations to reduce the incidence of iatrogenic vascular injury.

Traditional blood vessel detection methods are usually used to detect the shape of blood vessels, and the location information of microvessels cannot be obtained.

Contents of the invention

Embodiments of the present invention provide a method, device, system, and storage medium for detecting the position of microvessels, so as to solve the problem that traditional blood vessel detection methods cannot ascertain the position of microvessels, provide accurate position information of microvessels for medical operations, and further reduce medical costs. incidence of vascular injury.

According to one embodiment of the present invention, a method for detecting the position of microvessels is provided, the method comprising:

In response to detecting the trigger instruction, based on the first preset wavelength, control the light source in the signal collection array to irradiate the measured object, and obtain first reflected light signals respectively collected by at least two photodetectors in the signal collection array; wherein , the light source in the signal acquisition array is arranged linearly with each of the photodetectors;

For each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance;

Based on the target component distance and the detection depth corresponding to the photodetector, the blood vessel position of the microvessel is determined; wherein the detection depth represents the depth position of the signal acquisition array relative to the measured object.

According to another embodiment of the present invention, a device for detecting the position of microvessels is provided, the device comprising:

The first reflected light signal acquisition module is configured to control the light source in the signal acquisition array to irradiate the measured object based on the first preset wavelength in response to the detection of the trigger instruction, and acquire at least two photodetectors in the signal acquisition array respectively The collected first reflected light signal; wherein, the light source in the signal collection array is arranged linearly with each of the photodetectors;

The target component distance determining module is used for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the distance between the photodetector and the light source component distance as target component distance;

A blood vessel position determining module, configured to determine the blood vessel position of the microvessel based on the distance of the target component and the detection depth corresponding to the photodetector; wherein, the detection depth represents the position of the signal acquisition array relative to the direction of the measured object depth position.

According to another embodiment of the present invention, a microvessel position detection system is provided, and the system includes: a signal acquisition array and a controller;

Wherein, the signal acquisition array is provided with a light source and at least two photodetectors, and the light source is arranged linearly with each of the photodetectors;

The controller includes at least one processor; and a memory connected to the at least one processor in communication, the memory stores a computer program that can be executed by the at least one processor, and the computer program is executed by the at least one processor. Executed by a processor, so that the at least one processor can execute the method for detecting the position of a microvessel according to any embodiment of the present invention.

According to another embodiment of the present invention, a computer-readable storage medium is provided, the computer-readable storage medium stores computer instructions, and the computer instructions are used to enable a processor to implement any of the embodiments of the present invention when executed. A method for detecting the position of microvessels.

In the technical solution of the embodiment of the present invention, by responding to the detection of the trigger instruction, based on the first preset wavelength, the light source in the signal acquisition array is controlled to irradiate the measured object, and at least two photodetectors in the signal acquisition array are respectively acquired The first reflected light signal received, wherein, the light source in the signal acquisition array is arranged linearly with each photodetector, for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal , using the component distance between the photodetector and the light source as the target component distance, and based on the target component distance and the detection depth corresponding to the photodetector, determine the blood vessel position of the microvessel, which solves the problem that the traditional blood vessel detection method cannot ascertain the position of the microvessel , which provides accurate microvascular location information for medical operations, thereby reducing the incidence of iatrogenic vascular injury.

It should be understood that the content described in this section is not intended to identify key or important features of the embodiments of the present invention, nor is it intended to limit the scope of the present invention. Other features of the present invention will be easily understood from the following description.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings that need to be used in the description of the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present invention. For those skilled in the art, other drawings can also be obtained based on these drawings without creative effort.

FIG. 1 is a flow chart of a method for detecting the position of microvessels provided by Embodiment 1 of the present invention;

FIG. 2 is a schematic structural diagram of a signal acquisition array provided by Embodiment 1 of the present invention;

FIG. 3A is a visual schematic diagram of a blood flow pulsation signal provided by Embodiment 1 of the present invention;

FIG. 3B is a schematic diagram of blood vessel positions in a space coordinate system provided by Embodiment 1 of the present invention;

FIG. 4 is a flow chart of a method for detecting the position of microvessels provided by Embodiment 2 of the present invention;

Fig. 5 is a schematic diagram of the relationship between a light source detector distance and the average maximum penetration depth provided by Embodiment 2 of the present invention;

6 is a schematic structural diagram of a microvessel position detection device provided by Embodiment 3 of the present invention;

7 is a schematic structural diagram of a microvessel position detection system provided by Embodiment 4 of the present invention;

FIG. 8 is a schematic structural diagram of a specific example of a microvessel position detection system provided by Embodiment 4 of the present invention.

Detailed ways

In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate circumstances such that the embodiments of the invention described herein can be practiced in sequences other than those illustrated or described herein. Furthermore, the terms "comprising" and "having", as well as any variations thereof, are intended to cover a non-exclusive inclusion, for example, a process, method, system, product or device comprising a sequence of steps or elements is not necessarily limited to the expressly listed instead, may include other steps or elements not explicitly listed or inherent to the process, method, product or apparatus.

Embodiment one

Fig. 1 is a flow chart of a method for detecting the position of microvessels provided by Embodiment 1 of the present invention. This embodiment is applicable to the situation of finding out the specific position of the blood vessels in the subject in the medical operation scene, and the method can be It is performed by a microvessel position detection device, which may be implemented in the form of hardware and/or software, and the microvessel position detection device may be configured in a microvessel position detection system. As shown in Figure 1, the method includes:

S110. In response to detecting the trigger instruction, based on the first preset wavelength, control the light source in the signal collection array to irradiate the measured object, and obtain the first reflected light signals respectively collected by at least two photodetectors in the signal collection array .

In an optional embodiment, a trigger instruction is generated in response to detecting a manual operation instruction input by a user, and/or, when the time length between the current moment and the last detected moment satisfies a preset detection period, a trigger instruction is generated. Trigger command. Exemplarily, the preset detection period may be 5 seconds or 1 minute.

Wherein, specifically, the first preset wavelength may be used to characterize the wavelength of the electromagnetic wave emitted by the light source. Exemplarily, the first preset wavelength may be 650nm, 1064nm, 700nm, 900nm, 473nm or 532nm and so on. The first preset wavelength is not limited here. In an optional embodiment, the first preset wavelength is 650nm or 1064nm. The advantage of this setting is that 650nm and 1064nm represent red light and near-infrared light respectively. The attenuation of these two kinds of light in the tissue is small, which can effectively improve the maximum detection depth corresponding to the signal acquisition array, and thus broaden the application of microvascular position detection. scope of test.

In this embodiment, the light source in the signal collection array is arranged linearly with each photodetector. Specifically, the signal collection array includes a mounting board, and at least two photodetectors can be installed on one side of the light source, or on both sides of the light source. Wherein, the distance between two components in the signal collection array may be the same or different. The two components can be a light source and a photodetector, or a photodetector and a photodetector.

FIG. 2 is a schematic structural diagram of a signal acquisition array provided by Embodiment 1 of the present invention. Diagram A in FIG. 2 shows the situation that at least two photodetectors are installed on one side of the light source, and diagram B in FIG. 2 shows the situation that at least two photodetectors are installed on both sides of the light source. Of course, the number of photodetectors on both sides of the light source can be the same or different.

The tissue composition of the object to be measured is complex, and the refractive index mismatch between cells and organelles causes the incident light to enter the tissue, instead of propagating in a straight line, but rebounding multiple times to form diffuse reflection. The incident light passes through an approximately arc-shaped optical path and is reflected at a certain distance from the incident point. When the incident light passes through the blood vessel, due to the pulsation of the blood vessel, the first reflected light signal collected by the photodetector can reflect the pulsation information of the incident light passing through the tissue, and can be used to judge whether the incident light passes through the blood vessel.

S120. For each photodetector, if the first reflected light signal collected by the photodetector is a periodic signal, use the component distance between the photodetector and the light source as the target component distance.

In an optional embodiment, the method further includes: for each photodetector, inputting the first reflected light signal collected by the photodetector into the preamplifier, and inputting the output amplified reflected light signal into the analog In the digital converter; the digital reflected light signal output by the analog-to-digital converter is input into the data processing module to obtain the output blood flow pulsation signal, and when the blood flow pulsation signal is periodic, the first reflected light signal Set to periodic signal.

Wherein, for example, the data processing module may perform filtering processing and/or averaging processing on the digital reflected light signal.

In an optional embodiment, the method further includes: displaying blood pulse signals corresponding to each photodetector on a visual interface. FIG. 3A is a schematic diagram of visualization of a blood flow pulsation signal provided by Embodiment 1 of the present invention. Specifically, FIG. 3A shows blood pulse signals corresponding to five photodetectors respectively. Wherein, the abscissa of the coordinate system in FIG. 3A is time, and the ordinate is the signal intensity of the blood flow pulsation signal.

The advantage of this setting is that it is convenient for medical operators to observe the blood flow pulsation signal intuitively, and to have a certain prediction of the approximate location of the possible microvessels, so as to improve the real-time performance of obtaining the position information of the microvessels during the medical operation.

In an optional embodiment, the method further includes: matching the similarity between the blood flow pulsation signal and the standard pulsation signal, and if the matching rate exceeds a preset matching rate threshold, the blood flow pulsation signal is considered to be periodic.

In another optional embodiment, the method further includes: inputting the blood pulsation signal into a pre-trained classification model, and based on the output result, determining whether the blood pulsation signal has periodicity. Exemplarily, the output result is yes or 1, which is used to indicate that the blood flow pulsation signal has periodicity, and the output result is no or 0, which is used to indicate that the blood flow pulsation signal has no periodicity.

In another optional embodiment, the method further includes: determining the number of extreme values in the blood flow pulsation signal based on the preset statistical duration, and determining the beat frequency corresponding to the blood flow pulsation signal based on the number of extreme values, if the beat If the frequency satisfies the preset frequency range, the blood pulse signal is considered to be periodic. Wherein, the number of extreme values may be the number of maximum values or the number of minimum values. Exemplarily, the preset frequency range is 60-100 per minute.

In another optional embodiment, the method further includes: if the acquired parameter data satisfies a preset parameter condition, determining that the blood flow pulsation signal is periodic. Wherein, the parameter data includes at least two of the matching rate, the output result of the classification model, and the beating frequency, and the preset parameter conditions include that the matching rate exceeds the preset matching rate threshold, the output result is an identification result representing the periodicity of the blood flow pulsation signal, and The beat frequency satisfies the preset frequency range.

Wherein, specifically, when the first reflected light signal collected by the photodetector is a periodic signal, it indicates that there is a microvessel at the detection position corresponding to the current photodetector.

S130. Based on the target component distance and the detection depth corresponding to the photodetector, determine the vessel position of the microvessel.

In an optional embodiment, determining the blood vessel position of the microvessel based on the target component distance and the corresponding detection depth of the photodetector includes: constructing a space coordinate system based on the light source position corresponding to the light source in the signal collection array; And the detection depth corresponding to the photodetector determines the blood vessel position of the microvessel in the space coordinate system.

Wherein, specifically, the position of the light source corresponding to the light source in the signal collection array is taken as the origin of the space coordinate system. Exemplarily, the abscissa of the space coordinate system represents the component distance between the light source and each photodetector, and the ordinate represents the distance between each photodetector. The detection depths of the photodetectors are respectively corresponding.

In an optional embodiment, determining the blood vessel position of the microvessel in the spatial coordinate system based on the target component distance and the detection depth includes: taking the target component distance as the abscissa position in the blood vessel position, and taking the detection depth as the blood vessel position Ordinate position.

FIG. 3B is a schematic diagram of blood vessel positions in a space coordinate system provided by Embodiment 1 of the present invention. Specifically, Fig. 3B shows five photodetectors, wherein, the component distance between photodetector 1 and the light source is d1, and the component distance between the current photodetector and the previous photodetector or the next photodetector is The distances are all d2, correspondingly, the component distances between the five photodetectors and the light source are d1, d1+d2, d1+2*d2, d1+3*d2 and d1+4*d2 respectively. Wherein, taking the photodetector 1 as an example, the detection depth corresponding to the photodetector 1 can be the minimum detection depth (point a in Figure 3B), the middle detection depth (point b in Figure 3B) or the maximum detection depth (point b in Figure 3B point c in). Figure 3B takes the detection depth as the maximum detection depth as an example, assuming that the photodetector 3 and the collected first reflected light signal are periodic signals, then in the spatial coordinate system, the blood vessel position of the microvessel includes (d1+2*d2, M3).

In the technical solution of this embodiment, by responding to the detection of the trigger instruction, based on the first preset wavelength, the light source in the signal collection array is controlled to irradiate the measured object, and at least two photodetectors in the signal collection array are respectively collected The first reflected light signal of , wherein, the light source in the signal acquisition array is arranged linearly with each photodetector, for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, The component distance between the photodetector and the light source is used as the target component distance, and the position of the microvessel is determined based on the target component distance and the corresponding detection depth of the photodetector, which solves the problem that the traditional blood vessel detection method cannot ascertain the position of the microvessel. Accurate microvascular location information is provided for medical operations, thereby reducing the incidence of iatrogenic vascular injury.

Embodiment two

FIG. 4 is a flow chart of a method for detecting the position of a microvessel provided by Embodiment 2 of the present invention. This embodiment further refines the foregoing embodiment. As shown in Figure 4, the method includes:

S210. In response to detecting the trigger instruction, based on the first preset wavelength, control the light source in the signal collection array to irradiate the measured object, and obtain the first reflected light signals respectively collected by at least two photodetectors in the signal collection array .

S220. Based on the second preset wavelength, control the light source in the signal collection signal to irradiate the measured object, and acquire second reflected light signals respectively collected by at least two photodetectors in the signal collection array.

Wherein, specifically, the second preset wavelength is different from the first preset wavelength.

S230. For each photodetector, if the first reflected light signal collected by the photodetector is a periodic signal, use the component distance between the photodetector and the light source as the target component distance.

S240. Based on the target component distance and the detection depth corresponding to the photodetector, determine the vessel position of the microvessel.

On the basis of the above embodiments, the method further includes: for each photodetector in the signal acquisition array, inputting the component distance corresponding to the light source and the photodetector into the simulation system; outputting the maximum average penetration depth As the detection depth corresponding to the photodetector.

The closer the component distance between the photodetector and the light source is, the shallower the corresponding detection depth of the photodetector is, but the stronger the first reflected light intensity of the collected first reflected light signal is, on the contrary, the distance between the photodetector and the light source is The farther the distance between the components is, the deeper the corresponding detection depth of the photodetector is, but the weaker the first reflected light intensity of the collected first reflected light signal is.

In an optional embodiment, the simulation system may be a Monte Carlo simulation system. Monte Carlo simulation processes optical radiation into photon flow in the form of particles, in which each incident photon randomly interacts with the tissue in accordance with the law consistent with its physical behavior, such as walking, scattering and absorption, etc., through the analysis of these random events The tracking and statistics of a large number of incident photons can obtain the migration law and related parameters in the statistical average sense. The average maximum penetration depth of incident light at different component distances between the light source and photodetector can be obtained using Monte Carlo simulation.

FIG. 5 is a schematic diagram of a relationship between a light source detector distance and an average maximum penetration depth provided by Embodiment 2 of the present invention. From Figure 5, it can be seen that the average maximum penetration depth of the photodetector increases linearly as the component distance between the light source and photodetector increases. When the distance between the light source and the photodetector is greater than 40mm, the average maximum penetration depth of the photodetector no longer increases, and the maximum average maximum penetration depth is about 16mm. According to the results of the simulation experiment, the design of the signal acquisition array can be guided, such as the maximum component distance between the light source and the photodetector is not more than 40mm, within the distance range of 40mm, the photodetectors are evenly distributed, and the linear correspondence is different for the average maximum penetration depth.

In an optional embodiment, based on the target component distance and the detection depth, determining the blood vessel position of the microvessel in the spatial coordinate system includes: taking half of the target component distance as the abscissa position in the blood vessel position, and taking the detection depth as the blood vessel position The vertical coordinate position in . Taking the above example as an example, in this embodiment, the blood vessel positions of microvessels include

The advantage of such setting is that the accuracy of the blood vessel position of the microvessel can be improved.

In another optional embodiment, determining the blood vessel position of the microvessel in the spatial coordinate system based on the target component distance and the detection depth includes: determining the lateral position range based on the preset ratio range and the target component distance, based on the detection depth The minimum detection depth and the maximum detection depth determine the longitudinal position range, and determine the blood vessel position of the blood vessel in the spatial coordinate system based on the lateral position range and the longitudinal position range.

此处对预设比例范围不作限定。In this embodiment, the detection depth corresponding to the photodetector includes a minimum detection depth and a maximum detection depth, and the blood vessel position is used to characterize the distribution position area of the microvessel. Wherein, for example, the preset ratio range can be

The range of the preset ratio is not limited here.

其中，M3a表示光电探测器3对应的最小探测深度，M3c表示光电探测器3对应的最大探测深度。Taking the above example as an example, in this embodiment, the blood vessel positions of microvessels include

Wherein, M3a represents the minimum detection depth corresponding to the photodetector 3 , and M3c represents the maximum detection depth corresponding to the photodetector 3 .

The advantage of this setting is that it can provide a specific distribution location area of microvessels, avoiding the need for medical operators to estimate the distribution location area based on the location of blood vessels at a single coordinate point, thereby further improving the accuracy and practicability of the location of microvessels.

On the basis of the above embodiments, when the first reflected light signals collected by at least two photodetectors are all periodic signals, it is determined whether there is an overlapping area at the blood vessel positions corresponding to the at least two photodetectors, and if so , the coordinate position range corresponding to the overlapping area is taken as the vessel position of the microvessel with the highest priority.

The advantage of this setting is that the probability of blood vessels in the coordinate position range corresponding to the overlapping area is the highest. Therefore, taking the coordinate position range corresponding to the overlapping area as the blood vessel position of the highest priority microvessel can provide more accurate microvessel location for medical operations. Location information can further reduce the incidence of iatrogenic vascular injury.

S250. For each photodetector, acquire a first reflected light intensity and a second reflected light intensity respectively corresponding to the first reflected light signal and the second reflected light signal collected by the photodetector.

Wherein, for example, the first reflected light intensity can be represented by _I'λ1 , and the second reflected light intensity can be represented by I'λ2, wherein, λ1 and _λ2 represent the first preset wavelength and the second preset wavelength respectively.

S260. Based on the first reflected light intensity and the second reflected light intensity, determine the change amount of the blood oxygen concentration of the measured object at the detection depth corresponding to the photodetector.

In this embodiment, the change in blood oxygen concentration includes the change in oxygenated hemoglobin (HbO ₂ ) concentration and the change in deoxygenated hemoglobin (HHb) concentration.

Wherein, exemplary, the first reflected light intensity and the first incident light intensity satisfy the formula:

Wherein, for example, the formula between the second reflected light intensity and the second incident light intensity is satisfied:

和

分别表示在第一预设波长λ1的第一入射光下HbO₂和HHb分别对应的光吸收系数，

和

分别表示在第二预设波长λ2的第二入射光下HbO₂和HHb分别对应的光吸收系数，

和

分别表示t时刻的HbO₂浓度和HHb浓度，r表示光源与光电探测器之间的组件距离，DPF表示组件距离r的权重系数，称为差分路径因子，G^λ1表示在第一预设波长λ1的第一入射光下，被测对象中除了HbO₂和HHb的组织光吸收，G^λ2表示在第二预设波长λ2的第二入射光下，被测对象中除了HbO₂和HHb的组织光吸收。Among them, I _λ1 (t) and I _λ2 (t) respectively represent the first incident light intensity and the second incident light intensity at time t,

and

denote the light absorption coefficients corresponding to _HbO2 and HHb respectively under the first incident light of the first preset wavelength λ1,

and

represent the light absorption coefficients corresponding to _HbO2 and HHb respectively under the second incident light of the second preset wavelength λ2,

and

respectively represent the _HbO2 concentration and the HHb concentration at time t, r represents the component distance between the light source and the photodetector, DPF represents the weight coefficient of the component distance r, which is called the differential path factor, G ^λ1 represents that at the first preset wavelength λ1 Under the first incident light of , the tissue light absorption except HbO ₂ and HHb in the measured object, G ^λ2 represents the tissue light except HbO ₂ and HHb in the measured object under the second incident light of the second preset wavelength λ2 absorb.

Among them, G ^λ1 and G ^λ2 are unknown parameters, and it is usually assumed that G ^λ1 and G ^λ2 do not change with time. Therefore, the formula is constructed based on the first reflected light intensity and the second reflected light intensity at the previous moment (t-1):

和脱氧血红蛋白浓度变化量

By solving the above four formulas, the change in oxygenated hemoglobin concentration can be obtained

and deoxyhemoglobin concentration changes

In the technical solution of this embodiment, based on the second preset wavelength, the light source in the signal collection signal is controlled to irradiate the measured object, and the second reflected light signals respectively collected by at least two photodetectors in the signal collection array are obtained, aiming at Each photodetector obtains the first reflected light intensity and the second reflected light intensity respectively corresponding to the first reflected light signal and the second reflected light signal collected by the photodetector, based on the first reflected light intensity and the second reflected light Intensity, to determine the change in blood oxygen concentration of the measured object at the detection depth corresponding to the photodetector, which solves the problem that the traditional blood vessel detection method cannot analyze the change of blood oxygen concentration, and provides accurate blood oxygen concentration changes for medical operations Quantitative information enriches the dimensions of auxiliary information for medical operations and helps further reduce the incidence of iatrogenic vascular injury.

Embodiment Three

FIG. 6 is a schematic structural diagram of a microvessel position detection device provided by Embodiment 3 of the present invention. As shown in FIG. 6 , the device includes: a first reflected light signal acquisition module 310 , a target component distance determination module 320 and a blood vessel position determination module 330 .

Wherein, the first reflected light signal acquisition module 310 is configured to control the light source in the signal acquisition array to irradiate the measured object based on the first preset wavelength in response to the detection of the trigger instruction, and acquire at least two photoelectric signals in the signal acquisition array. The first reflected light signals collected by the detectors respectively; wherein, the light source in the signal collection array is linearly arranged with each photodetector;

Target component distance determination module 320, for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, use the component distance between the photodetector and the light source as the target component distance;

The blood vessel position determination module 330 is configured to determine the blood vessel position of the microvessel based on the target component distance and the detection depth corresponding to the photodetector; wherein the detection depth represents the depth position of the signal acquisition array relative to the measured object.

In the technical solution of this embodiment, by responding to the detection of the trigger instruction, based on the first preset wavelength, the light source in the signal collection array is controlled to irradiate the measured object, and at least two photodetectors in the signal collection array are respectively collected The first reflected light signal of , wherein, the light source in the signal acquisition array is arranged linearly with each photodetector, for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, The component distance between the photodetector and the light source is used as the target component distance, and the position of the microvessel is determined based on the target component distance and the corresponding detection depth of the photodetector, which solves the problem that the traditional blood vessel detection method cannot ascertain the position of the microvessel. Accurate microvascular location information is provided for medical operations, thereby reducing the incidence of iatrogenic vascular injury.

On the basis of the foregoing embodiments, optionally, the device further includes:

The blood flow pulsation signal determination module is used for inputting the first reflected light signal collected by the photodetector into the preamplifier for each photodetector, and inputting the output amplified reflected light signal into the analog-to-digital converter ;

Input the digital reflected light signal output by the analog-to-digital converter into the data processing module to obtain the output blood flow pulsation signal, and set the first reflected light signal as a periodic signal when the blood flow pulsation signal is periodic .

On the basis of the above embodiments, optionally, the blood vessel position determining module 330 is specifically used for:

Constructing a space coordinate system based on the position of the light source corresponding to the light source in the signal acquisition array;

Based on the target component distance and the detection depth corresponding to the photodetector, the vessel position of the microvessel in the space coordinate system is determined.

On the basis of the foregoing embodiments, optionally, the device further includes:

The detection depth determination module is used for inputting the component distance corresponding to the light source and the photodetector into the simulation system for each photodetector in the signal acquisition array;

The output maximum average penetration depth is taken as the detection depth corresponding to the photodetector.

On the basis of the foregoing embodiments, optionally, the device further includes:

The blood oxygen concentration variation determination module is configured to control the light source in the signal collection signal to irradiate the measured object based on the second preset wavelength, and obtain the second reflected light signals respectively collected by at least two photodetectors in the signal collection array ;

For each photodetector, obtain the first reflected light intensity and the second reflected light intensity respectively corresponding to the first reflected light signal and the second reflected light signal collected by the photodetector;

Based on the first reflected light intensity and the second reflected light intensity, determine the blood oxygen concentration variation of the measured object at the detection depth corresponding to the photodetector; wherein, the blood oxygen concentration variation includes oxygenated hemoglobin concentration variation and deoxygenation Change in hemoglobin concentration.

The microvessel position detection device provided in the embodiments of the present invention can execute the microvessel position detection method provided in any embodiment of the present invention, and has corresponding functional modules and beneficial effects for executing the method.

Embodiment Four

FIG. 7 is a schematic structural diagram of a microvessel position detection system provided by Embodiment 4 of the present invention. The system can provide services for the microvessel position detection method provided in the above embodiments, and can be configured with the microvessel position detection device provided in the above embodiments. The components in the microvascular position detection system shown in the embodiments of the present invention, their connections and relationships, and their functions are merely examples, and are not intended to limit the implementation of the present invention described and/or claimed herein.

As shown in Figure 7, the system includes: a signal acquisition array 410 and a controller 420; wherein, the signal acquisition array 410 is provided with a light source 411 and at least two photodetectors 412, and the light source 411 and each photodetector 412 are linearly arranged; The controller includes at least one processor 421 and a memory 422 communicatively connected with the at least one processor 421 .

Specifically, the signal collection array 410 includes a mounting board, and at least two photodetectors 412 may be installed on one side of the light source 411 or on both sides of the light source 411 . Wherein, the distance between two components in the signal collection array 410 may be the same or different. The two components may be a light source 411 and a photodetector 412 , or a photodetector 412 and a photodetector 412 .

In an optional embodiment, the component distance between different detectors and the light source 411 is an integer multiple of d. Among them, the user can customize the parameter value of d according to actual needs. The advantage of such setting is that regular component distances can reduce the complexity of blood vessel positions provided to medical operators, so that medical operators can grasp the blood vessel positions of microvessels in a timely and accurate manner.

In an optional embodiment, the light source 411 in the signal collection array 410 is a photodiode or a laser light source 411. When the light source 411 is a laser light source 411, the system further includes: a laser, a fiber coupler and an optical fiber, and the laser is used to emit laser light. , the fiber coupler is used to transmit the received laser light to the optical fiber, and the optical fiber is used to transmit the laser light to the laser light source 411 .

In an optional embodiment, the core diameter of the optical fiber is no more than 250 μm, and the photosensitive area of the photodetector 412 is less than 0.25 m ² . Exemplarily, the optical fiber, the light source 411 and the photodetector 412 are packaged together to form a front-end sensor. The advantage of this setting is that, in medical operation scenarios, the spatial range where the signal acquisition array 410 can be placed is usually relatively small, so the requirement for the volume of the signal acquisition array is relatively high. In this embodiment, while ensuring the accuracy of the blood vessel position, the volume of the signal acquisition array 410 is reduced as much as possible, which can meet the volume requirement of the signal acquisition array 410 in medical operation scenarios.

In an optional embodiment, the system further includes: a preamplifier, an analog-to-digital converter, and a data processing module, wherein the preamplifier is used to output amplified reflected light signals based on the input first reflected light signal, and the analog-to-digital conversion The device is used to output a digital reflected light signal based on the input amplified reflected light signal, and the data processing module is used to output a blood flow pulsation signal based on the input digital reflected light signal.

Wherein, the memory 422 stores a computer program that can be executed by at least one processor 421, and the processor 421 can execute the computer program according to the computer program stored in the read-only memory (ROM) or loaded from the storage unit to the random access memory (RAM). programs to perform various appropriate actions and processes. In the RAM, various programs and data necessary for the operation of the controller 420 can also be stored. The processor 421, ROM, and RAM are connected to each other through a bus.

Processor 421 may be various general and/or special purpose processing components having processing and computing capabilities. Some examples of processor 421 include, but are not limited to, central processing units (CPUs), graphics processing units (GPUs), various specialized artificial intelligence (AI) computing chips, various processors that run machine learning model algorithms, digital signal processing processor (DSP), and any suitable processor, controller, microcontroller, etc. The processor 421 executes various methods and processes described above, for example, a method for detecting the position of microvessels.

Various implementations of the systems and techniques described above herein can be implemented in digital electronic circuit systems, integrated circuit systems, field programmable gate arrays (FPGAs), application specific integrated circuits (ASICs), application specific standard products (ASSPs), systems on chips Implemented in a system of systems (SOC), load programmable logic device (CPLD), computer hardware, firmware, software, and/or combinations thereof. These various embodiments may include being implemented in one or more computer programs executable and/or interpreted on a programmable system including at least one programmable processor, the programmable processor Can be special-purpose or general-purpose programmable processor, can receive data and instruction from storage system, at least one input device, and at least one output device, and transmit data and instruction to this storage system, this at least one input device, and this at least one output device an output device.

FIG. 8 is a schematic structural diagram of a specific example of a microvessel position detection system provided by Embodiment 4 of the present invention. Specifically, the microvascular position detection system shown in FIG. 8 includes a laser for emitting a laser with a wavelength of 650nm, a laser for emitting a laser with a wavelength of 1064nm, a mirror, a signal collection array, a fiber coupler, a controller, a preamplifier, Analog-to-digital converters, data processors, and displays.

The controller can be used to control the opening and closing of the shutter of any laser. Specifically, in response to detecting the trigger instruction, the controller selects a laser with any incident light wavelength and controls the shutter of the laser to open. The laser light enters the optical coupler after being reflected by two mirrors, and then propagates through the optical fiber and enters the laser light source in the signal acquisition array, and the laser light source emits incident light to irradiate the measured object. At least two photodetectors in the signal collection array collect the first reflected light signals respectively, and after each first reflected light signal passes through the preamplifier, the analog-to-digital converter and the data processing module in sequence, at least two output signals from the data processing module are obtained. blood flow pulsation signal, and each blood flow pulsation signal is displayed on the monitor in real time.

The microvessel position detection system provided in this embodiment solves the problem that the traditional blood vessel detection method cannot ascertain the position of the microvessel, provides accurate microvessel position information for medical operations, and can reduce the incidence of iatrogenic vascular injury.

Embodiment five

Embodiment 5 of the present invention also provides a computer-readable storage medium, the computer-readable storage medium stores computer instructions, and the computer instructions are used to make the processor execute a method for detecting the position of microvessels, the method comprising:

In response to detecting the trigger instruction, based on the first preset wavelength, control the light source in the signal collection array to irradiate the measured object, and obtain first reflected light signals respectively collected by at least two photodetectors in the signal collection array; wherein , the light source in the signal acquisition array is arranged linearly with each photodetector;

For each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance;

Based on the distance of the target component and the detection depth corresponding to the photodetector, the blood vessel position of the microvessel is determined; wherein, the detection depth represents the depth position of the signal acquisition array relative to the direction of the measured object.

In the context of the present invention, a computer readable storage medium may be a tangible medium that may contain or store a computer program for use by or in conjunction with an instruction execution system, apparatus or device. A computer readable storage medium may include, but is not limited to, electronic, magnetic, optical, electromagnetic, infrared, or semiconductor systems, apparatus, or devices, or any suitable combination of the foregoing. Alternatively, a computer readable storage medium may be a machine readable signal medium. More specific examples of machine-readable storage media would include one or more wire-based electrical connections, portable computer disks, hard disks, Random Access Memory (RAM), Read Only Memory (ROM), Erasable Programmable Read Only Memory (EPROM or flash memory), optical fiber, compact disk read only memory (CD-ROM), optical storage, magnetic storage, or any suitable combination of the foregoing.

In order to provide interaction with the user, the systems and techniques described herein can be implemented on an electronic device having a display device (e.g., a CRT (cathode ray tube) or LCD (liquid crystal display)) for displaying information to the user. monitor); and a keyboard and pointing device (eg, a mouse or a trackball) through which the user can provide input to the electronic device. Other kinds of devices can also be used to provide interaction with the user; for example, the feedback provided to the user can be any form of sensory feedback (e.g., visual feedback, auditory feedback, or tactile feedback); and can be in any form (including Acoustic input, speech input or, tactile input) to receive input from the user.

The systems and techniques described herein can be implemented in a computing system that includes back-end components (e.g., as a data server), or a computing system that includes middleware components (e.g., an application server), or a computing system that includes front-end components (e.g., as a a user computer having a graphical user interface or web browser through which a user can interact with embodiments of the systems and techniques described herein), or including such backend components, middleware components, Or any combination of front-end components in a computing system. The components of the system can be interconnected by any form or medium of digital data communication, eg, a communication network. Examples of communication networks include: local area networks (LANs), wide area networks (WANs), blockchain networks, and the Internet.

A computing system can include clients and servers. Clients and servers are generally remote from each other and typically interact through a communication network. The relationship of client and server arises by computer programs running on the respective computers and having a client-server relationship to each other. The server can be a cloud server, also known as a cloud computing server or a cloud host. It is a host product in the cloud computing service system to solve the problems of difficult management and weak business expansion in traditional physical hosts and VPS services. defect.

It should be understood that steps may be reordered, added or deleted using the various forms of flow shown above. For example, each step described in the present invention may be executed in parallel, sequentially, or in a different order, as long as the desired result of the technical solution of the present invention can be achieved, there is no limitation herein.

The above specific implementation methods do not constitute a limitation to the protection scope of the present invention. It should be apparent to those skilled in the art that various modifications, combinations, sub-combinations and substitutions may be made depending on design requirements and other factors. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (10)

1. A method for detecting the position of a microvessel, comprising: In response to detecting the trigger instruction, based on the first preset wavelength, control the light source in the signal collection array to irradiate the measured object, and obtain first reflected light signals respectively collected by at least two photodetectors in the signal collection array; wherein , the light source in the signal acquisition array is arranged linearly with each of the photodetectors; For each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance; Based on the target component distance and the detection depth corresponding to the photodetector, the blood vessel position of the microvessel is determined; wherein the detection depth represents the depth position of the signal acquisition array relative to the measured object. 2. The method according to claim 1, characterized in that the method further comprises: For each photodetector, input the first reflected light signal collected by the photodetector into the preamplifier, and input the output amplified reflected light signal into the analog-to-digital converter; Inputting the digital reflected light signal output by the analog-to-digital converter into the data processing module to obtain the output blood flow pulsation signal, and when the blood flow pulsation signal is periodic, the first reflected light The signal is set to be a periodic signal. 3. The method according to claim 1, wherein the determination of the blood vessel position of the microvessel based on the target component distance and the detection depth corresponding to the photodetector comprises: Constructing a spatial coordinate system based on the position of the light source corresponding to the light source in the signal collection array; Based on the target component distance and the detection depth corresponding to the photodetector, the blood vessel position of the microvessel in the space coordinate system is determined. 4. The method according to claim 1, wherein the method further comprises: For each photodetector in the signal acquisition array, input the component distance corresponding to the light source and the photodetector into the simulation system; The output maximum average penetration depth is taken as the detection depth corresponding to the photodetector. 5. The method according to any one of claims 1-4, characterized in that the method further comprises: Based on the second preset wavelength, control the light source in the signal collection signal to irradiate the measured object, and obtain second reflected light signals respectively collected by at least two photodetectors in the signal collection array; For each photodetector, obtain the first reflected light intensity and the second reflected light intensity respectively corresponding to the first reflected light signal and the second reflected light signal collected by the photodetector; Based on the first reflected light intensity and the second reflected light intensity, determine the blood oxygen concentration change amount of the measured object at the detection depth corresponding to the photodetector; wherein the blood oxygen concentration change amount includes The amount of change in the concentration of oxygenated hemoglobin and the amount of change in the concentration of deoxygenated hemoglobin. 6. A position detection device for microvessels, comprising: The first reflected light signal acquisition module is configured to control the light source in the signal acquisition array to irradiate the measured object based on the first preset wavelength in response to the detection of the trigger instruction, and acquire at least two photodetectors in the signal acquisition array respectively The collected first reflected light signal; wherein, the light source in the signal collection array is arranged linearly with each of the photodetectors; The target component distance determining module is used for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the distance between the photodetector and the light source component distance as target component distance; A blood vessel position determining module, configured to determine the blood vessel position of the microvessel based on the distance of the target component and the detection depth corresponding to the photodetector; wherein, the detection depth represents the position of the signal acquisition array relative to the direction of the measured object depth position. 7. A microvascular position detection system, comprising: a signal acquisition array and a controller; Wherein, the signal acquisition array is provided with a light source and at least two photodetectors, and the light source is arranged linearly with each of the photodetectors; The controller includes at least one processor and a memory connected in communication with the at least one processor, the memory stores a computer program executable by the at least one processor, and the computer program is executed by the at least one processor executed by a processor, so that the at least one processor can execute the method for detecting the position of a microvessel according to any one of claims 1-5. 8. The system according to claim 7, wherein the system further comprises: a preamplifier, an analog-to-digital converter and a data processing module, wherein the preamplifier is used for the first reflected light based on the input The signal outputs an amplified reflected light signal, the analog-to-digital converter is used to output a digital reflected light signal based on the input amplified reflected light signal, and the data processing module is used to output a blood flow pulsation signal based on the input digital reflected light signal. 9. The system according to claim 7, wherein the light source in the signal acquisition array is a photodiode or a laser light source, and when the light source is a laser light source, the system also includes: a laser, a fiber coupler and an optical fiber, the laser is used to emit laser light, the fiber coupler is used to transmit the received laser light to the optical fiber, and the optical fiber is used to transmit the laser light to the laser light source. 10. A computer-readable storage medium, characterized in that the computer-readable storage medium stores computer instructions, and the computer instructions are used to enable a processor to implement the method described in any one of claims 1-5 when executed. Microvessel position detection method.

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