CN115251853A - Method, device and system for detecting position of microvascular and storage medium - Google Patents
Method, device and system for detecting position of microvascular and storage medium Download PDFInfo
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Abstract
The invention discloses a method, a device, a system and a storage medium for detecting the position of a microvascular, wherein the method comprises the following steps: responding to the detection of a trigger instruction, controlling a light source in a signal acquisition array to irradiate a measured object based on a first preset wavelength, and acquiring first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array; wherein, the light source in the signal acquisition array is linearly arranged with each photoelectric detector; for each photoelectric detector, taking the assembly distance between the photoelectric detector and the light source as the target assembly distance under the condition that the first reflected light signal acquired by the photoelectric detector is a periodic signal; and determining the position of the blood vessel of the micro blood vessel based on the target component distance and the corresponding detection depth of the photoelectric detector. The embodiment of the invention solves the problem that the position of the microvasculature cannot be ascertained by the traditional blood vessel detection method, provides accurate position information of the microvasculature for medical operation, and further can reduce the incidence rate of iatrogenic vascular injury.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a method, a device and a system for detecting the position of a microvascular and a storage medium.
Background
Iatrogenic vascular injury refers to vascular injury occurring unexpectedly in the process of medical operation, and although great vascular injury is greatly reduced along with popularization and improvement of vascular surgical knowledge, micro-vascular injury caused by misoperation is still difficult to avoid. While the microvessels play a significant role in the blood supply to peripheral tissues, for example, damage to the microvessels supplying the nerve may result in damage to the function of the nerve. Therefore, judging whether the microvessels exist or not and ascertaining the specific positions of the microvessels in the medical operation process are particularly important for reducing the incidence of iatrogenic vascular injuries.
The conventional blood vessel detection method is generally used for detecting the morphology of blood vessels, and position information of microvessels cannot be obtained.
Disclosure of Invention
The embodiment of the invention provides a method, a device and a system for detecting the position of a microvascular and a storage medium, which are used for solving the problem that the position of the microvascular cannot be ascertained by the traditional blood vessel detection method, providing accurate position information of the microvascular for medical operation and further reducing the incidence rate of iatrogenic vascular injury.
According to an embodiment of the present invention, there is provided a method of detecting a position of a microvascular, the method including:
responding to the detection of a trigger instruction, controlling a light source in a signal acquisition array to irradiate a measured object based on a first preset wavelength, and acquiring first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array; wherein, the light source and each photoelectric detector in the signal acquisition array are arranged linearly;
for each photoelectric detector, taking a component distance between the photoelectric detector and the light source as a target component distance when a first reflected light signal acquired by the photoelectric detector is a periodic signal;
determining the position of the blood vessel of the micro blood vessel based on the target component distance and the detection depth corresponding to the photoelectric detector; wherein the detection depth represents the depth position of the signal acquisition array relative to the direction of the measured object.
According to another embodiment of the present invention, there is provided a microvascular position detection apparatus including:
the first reflected light signal acquisition module is used for responding to the detection of a trigger instruction, controlling a light source in the signal acquisition array to irradiate the measured object based on a first preset wavelength, and acquiring first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array; the light sources in the signal acquisition array and the photodetectors are linearly arranged;
a target component distance determination module, configured to, for each photodetector, take a component distance between the photodetector and the light source as a target component distance when a first reflected light signal acquired by the photodetector is a periodic signal;
the blood vessel position determining module is used for determining the blood vessel position of the micro blood vessel based on the target component distance and the detection depth corresponding to the photoelectric detector; wherein the detection depth represents the depth position of the signal acquisition array relative to the direction of the measured object.
According to another embodiment of the present invention, there is provided a position detection system of a micro blood vessel, the system including: a signal acquisition array and a controller;
the signal acquisition array is provided with a light source and at least two photoelectric detectors, and the light source and each photoelectric detector are linearly arranged;
the controller comprises at least one processor; and a memory communicatively coupled to the at least one processor, the memory storing a computer program executable by the at least one processor, the computer program being executable by the at least one processor to enable the at least one processor to perform a method of location detection of a microvasculature as set forth in any one of the embodiments of the present invention.
According to another embodiment of the present invention, a computer-readable storage medium is provided, which stores computer instructions for causing a processor to implement the method for detecting the position of a microvascular in any one of the embodiments of the present invention when the computer instructions are executed.
According to the technical scheme of the embodiment of the invention, the light source in the signal acquisition array is controlled to irradiate the measured object based on the first preset wavelength in response to the detection of the trigger instruction, the first reflected light signals acquired by at least two photoelectric detectors in the signal acquisition array are acquired, wherein the light source in the signal acquisition array and each photoelectric detector are linearly arranged, and for each photoelectric detector, under the condition that the first reflected light signals acquired by the photoelectric detectors are periodic signals, the assembly distance between the photoelectric detectors and the light source is taken as the target assembly distance, and the blood vessel position of the blood vessel is determined based on the target assembly distance and the detection depth corresponding to the photoelectric detectors.
It should be understood that the statements in this section do not necessarily identify key or critical features of the embodiments of the present invention, nor do they necessarily limit the scope of the invention. Other features of the present invention will become apparent from the following description.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 is a flowchart of a method for detecting a position of a capillary vessel according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a signal acquisition array according to an embodiment of the present invention;
fig. 3A is a schematic diagram illustrating a visualization of a blood flow pulsation signal according to an embodiment of the present invention;
FIG. 3B is a schematic diagram of the position of a blood vessel in a space coordinate system according to an embodiment of the present invention;
fig. 4 is a flowchart of a method for detecting a position of a capillary vessel according to a second embodiment of the present invention;
FIG. 5 is a schematic diagram illustrating the relationship between the distance of the light source and the detector and the average maximum penetration depth according to a second embodiment of the present invention;
fig. 6 is a schematic structural diagram of a microvascular location detection apparatus according to a third embodiment of the present invention;
fig. 7 is a schematic structural diagram of a system for detecting a position of a microvascular vessel according to a fourth embodiment of the present invention;
fig. 8 is a schematic structural diagram of a specific example of a system for detecting a position of a microvascular vessel according to a fourth embodiment of the present invention.
Detailed Description
In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that the terms "first," "second," and the like in the description and claims of the present invention and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the invention described herein are capable of operation in other sequences than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
Example one
Fig. 1 is a flowchart of a method for detecting a position of a microvascular vessel according to an embodiment of the present invention, which is applicable to a situation where a specific position of a blood vessel in a measured object is detected in a medical operation scenario, and the method may be performed by a microvascular position detecting apparatus, which may be implemented in a form of hardware and/or software, and the microvascular position detecting apparatus may be configured in a microvascular position detecting system. As shown in fig. 1, the method includes:
s110, responding to the detected trigger instruction, controlling a light source in the signal acquisition array to irradiate the measured object based on a first preset wavelength, and acquiring first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array.
In an optional embodiment, the trigger instruction is generated in response to detecting a manual operation instruction input by a user, and/or the trigger instruction is generated in case that the time length between the current time and the last detection time meets a preset detection period. For example, the preset detection period may be 5 seconds or 1 minute.
Specifically, the first preset wavelength may be used to represent a wavelength of an electromagnetic wave emitted by the light source. Illustratively, the first preset wavelength may be 650nm, 1064nm, 700nm, 900nm, 473nm, 532nm, or the like. The first predetermined wavelength is not limited herein. In an alternative embodiment, the first predetermined wavelength is 650nm or 1064nm. The advantage of setting up like this is, 650nm and 1064nm represent red light and near-infrared light respectively, and these two kinds of light decay in the tissue is little, can effectively improve the maximum detection depth that the signal acquisition array corresponds, and then can widen the application detection range that the capillary position detected.
In this embodiment, the light sources in the signal collection array are linearly arranged with the photodetectors. Wherein, it is specific, include the mounting panel in the signal acquisition array, at least two photoelectric detector can all install the one side at the light source, also can install the both sides at the light source. The distances between the two assemblies in the signal acquisition array can be the same or different. The two components may be a light source and a photodetector, or a photodetector and a photodetector.
Fig. 2 is a schematic structural diagram of a signal acquisition array according to an embodiment of the present invention. Fig. 2 a shows a case where at least two photodetectors are both mounted on one side of the light source, and fig. 2B shows a case where at least two photodetectors are mounted on both sides of the light source. Of course, the number of photodetectors on either side of the light source may be the same or different.
The tissue components of the tested object are complex, and the refractive indexes of the cells and the organelles are not matched, so that incident light enters the tissue and does not propagate in a straight line but rebounds for multiple times to form diffuse reflection. The incident light is reflected out at a position having a certain distance from the incident point through an approximately arc-shaped optical path. When the incident light passes through the blood vessel, due to the pulsation of the blood vessel, the first reflected light signal acquired by the photoelectric detector can reflect the pulsation information of the incident light passing through the tissue, and can be used for judging whether the incident light passes through the blood vessel.
And S120, regarding each photoelectric detector, and taking the assembly distance between the photoelectric detector and the light source as a target assembly distance under the condition that the first reflected light signal acquired by the photoelectric detector is a periodic signal.
In an optional embodiment, the method further comprises: for each photoelectric detector, inputting a first reflected light signal collected by the photoelectric detector into a preamplifier, and inputting an output amplified reflected light signal into an analog-to-digital converter; the digital reflected light signal output by the analog-to-digital converter is input into the data processing module to obtain the output blood flow pulsation signal, and the first reflected light signal is set as a periodic signal under the condition that the blood flow pulsation signal has periodicity.
For example, the data processing module may perform a filtering process and/or an averaging process on the digital reflected light signal.
In an optional embodiment, the method further comprises: and displaying the blood flow pulsation signals respectively corresponding to the photoelectric detectors in a visual interface. Fig. 3A is a schematic view of a visualization of a blood flow pulsation signal according to an embodiment of the present invention. Specifically, fig. 3A shows blood flow pulsation signals respectively corresponding to 5 photodetectors. In fig. 3A, the abscissa of the coordinate system is time, and the ordinate is the signal intensity of the blood flow pulsation signal.
The blood flow pulsation signal can be conveniently and visually observed by medical operators, and the approximate position of the capillary vessel which may exist is pre-judged to a certain extent, so that the real-time property of acquiring the position information of the capillary vessel in the medical operation process is improved.
In an optional embodiment, the method further comprises: and performing similarity matching on the blood flow pulsation signal and the standard pulsation signal, and if the matching rate exceeds a preset matching rate threshold value, determining that the blood flow pulsation signal has periodicity.
In another optional embodiment, the method further comprises: the blood flow pulsation signal is input to a classification model trained in advance, and whether the blood flow pulsation signal has periodicity or not is determined based on the output result. Illustratively, the output result is yes or 1 for indicating that the blood flow pulsation signal has periodicity, and the output result is no or 0 for indicating that the blood flow pulsation signal does not have periodicity.
In another optional embodiment, the method further comprises: the number of extreme values in the blood flow pulsation signal is determined based on the preset statistical duration, the pulsation frequency corresponding to the blood flow pulsation signal is determined based on the number of the extreme values, and if the pulsation frequency meets the preset frequency range, the blood flow pulsation signal is considered to have periodicity. The number of extreme values may be a maximum value and a minimum value, and the preset frequency range is 60-100 numbers per minute.
In another optional embodiment, the method further comprises: and if the acquired parameter data meet the preset parameter conditions, the blood flow pulsation signal is considered to have periodicity. The parameter data comprises at least two of matching rate, an output result of the classification model and the beating frequency, the preset parameter conditions comprise that the matching rate exceeds a preset matching rate threshold value, the output result is an identification result representing that the blood flow beating signal has periodicity, and the beating frequency meets a preset frequency range.
Specifically, when the first reflected light signal acquired by the photodetector is a periodic signal, it is indicated that a capillary is present at the detection position corresponding to the current photodetector.
And S130, determining the position of the blood vessel of the micro blood vessel based on the target assembly distance and the detection depth corresponding to the photoelectric detector.
In an alternative embodiment, determining the vessel location of the microvasculature based on the target assembly distance and the corresponding detection depth of the photodetector comprises: constructing a space coordinate system based on the light source position corresponding to the light source in the signal acquisition array; and determining the position of the blood vessel of the micro blood vessel in the space coordinate system based on the target component distance and the detection depth corresponding to the photoelectric detector.
Specifically, the light source position corresponding to the light source in the signal acquisition array is used as the origin of a space coordinate system, for example, the abscissa of the space coordinate system represents the assembly distance between the light source and each photodetector, and the ordinate represents the detection depth corresponding to each photodetector.
In an alternative embodiment, determining the vessel location of the microvasculature in the spatial coordinate system based on the target assembly distance and the probe depth comprises: the target assembly distance is taken as the abscissa position in the vessel position and the probe depth is taken as the ordinate position in the vessel position.
Fig. 3B is a schematic diagram of a blood vessel position in a space coordinate system according to an embodiment of the present invention. Specifically, fig. 3B shows 5 photodetectors, where the assembly distance between the photodetector 1 and the light source is d1, the assembly distances between the current photodetector and the previous or next photodetector are d2, and correspondingly, the assembly distances between the 5 photodetectors and the light source are d1, d1+ d2, d1+2 × d2, d1+3 × d2, and d1+4 × d2, respectively. Taking the photodetector 1 as an example, the detection depth corresponding to the photodetector 1 may be a minimum detection depth (point a in fig. 3B), an intermediate detection depth (point B in fig. 3B), or a maximum detection depth (point c in fig. 3B). Fig. 3B illustrates the maximum detection depth as the detection depth, and assuming that the photodetector 3 and the collected first reflected light signal are periodic signals, the blood vessel position of the micro blood vessel includes (d 1+2 × d2, M3) in the spatial coordinate system.
According to the technical scheme of the embodiment, the light source in the signal acquisition array is controlled to irradiate the object to be measured based on the first preset wavelength in response to the detection of the trigger instruction, the first reflected light signals acquired by at least two photodetectors in the signal acquisition array are acquired, wherein the light source in the signal acquisition array and each photodetector are linearly arranged, for each photodetector, under the condition that the first reflected light signal acquired by the photodetector is a periodic signal, the assembly distance between the photodetector and the light source is taken as the target assembly distance, and the position of the blood vessel is determined based on the target assembly distance and the detection depth corresponding to the photodetector.
Example two
Fig. 4 is a flowchart of a method for detecting a location of a capillary vessel according to a second embodiment of the present invention, which is further detailed in the present embodiment. As shown in fig. 4, the method includes:
s210, responding to the detected trigger instruction, controlling a light source in the signal acquisition array to irradiate the measured object based on a first preset wavelength, and acquiring first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array.
And S220, controlling a light source in the signal acquisition signal to irradiate the measured object based on a second preset wavelength, and acquiring second reflected light signals respectively acquired by at least two photoelectric detectors in the signal acquisition array.
Specifically, the second predetermined wavelength is different from the first predetermined wavelength.
And S230, regarding each photoelectric detector, and taking the assembly distance between the photoelectric detector and the light source as the target assembly distance under the condition that the first reflected light signal acquired by the photoelectric detector is a periodic signal.
And S240, determining the position of the blood vessel of the micro blood vessel based on the target assembly distance and the detection depth corresponding to the photoelectric detector.
On the basis of the above embodiment, the method further includes: inputting the assembly distance corresponding to the light source and the photoelectric detector into an analog simulation system aiming at each photoelectric detector in the signal acquisition array; and taking the output maximum average penetration depth as the corresponding detection depth of the photoelectric detector.
The closer the assembly distance between the photodetector and the light source, the shallower the detection depth corresponding to the photodetector, but the stronger the first reflected light intensity of the collected first reflected light signal, and conversely, the farther the assembly distance between the photodetector and the light source, the deeper the detection depth corresponding to the photodetector, but the weaker the first reflected light intensity of the collected first reflected light signal.
In an alternative embodiment, the analog simulation system may be a Monte Carlo simulation system. Monte Carlo simulation processes light radiation into photon flow in particle form, wherein each incident photon in the tissue body according to the same rule as its physical behavior and the random effect with the tissue, such as walking, scattering and absorption, through the random events tracking and statistics, can obtain the migration rule and related parameters of a large number of incident photons in statistical mean. The average maximum penetration depth of incident light at different distances of components between the light source and the photodetector can be obtained using a monte carlo simulation method.
Fig. 5 is a schematic diagram illustrating a relationship between a distance of a light source and a detector and an average maximum penetration depth according to a second embodiment of the present invention. As can be seen from fig. 5, the average maximum penetration depth of the photodetectors increases linearly with increasing assembly distance between the light source and the photodetectors. When the distance between the light source and the photodetector is greater than 40mm, the average maximum penetration depth of the photodetector does not increase any more, and the maximum average maximum penetration depth is about 16mm. According to the result of the simulation experiment, the design of the signal acquisition array can be guided, for example, the maximum assembly distance between the light source and the photoelectric detector does not exceed 40mm, and the photoelectric detector is evenly distributed within the distance range of 40mm, and linearly corresponds to different average maximum penetration depths.
In an alternative embodiment, determining the vessel location of the microvasculature in the spatial coordinate system based on the target assembly distance and the probe depth comprises: half of the target assembly distance is taken as the abscissa position in the vessel position and the probe depth is taken as the ordinate position in the vessel position. Taking the above example as an example, in the present embodiment, the blood vessel position of the microvasculature includes
This has the advantage that the accuracy of the vessel position of the microvessels can be improved.
In another alternative embodiment, determining the vessel location of the microvasculature in the spatial coordinate system based on the target assembly distance and the probe depth comprises: determining a transverse position range based on a preset proportion range and the target component distance, determining a longitudinal position range based on the minimum detection depth and the maximum detection depth in the detection depths, and determining the position of the blood vessel in a space coordinate system based on the transverse position range and the longitudinal position range.
In the present embodiment, the detection depth corresponding to the photodetector includes a minimum detection depth and a maximum detection depth, and the blood vessel position is used to characterize the distribution position area of the micro blood vessel. Wherein, for example, the preset proportion range may be
The predetermined ratio range is not limited herein.
Taking the above example as an example, in the present embodiment, the blood vessel position of the microvasculature includes
Wherein M3a represents the minimum detection depth corresponding to the photodetector 3, and M3c represents the photodetectionThe maximum depth of investigation for the detector 3.
The advantage of setting up like this is that can provide the distribution position area of specific microvascular, avoids medical operating personnel to need to carry out the estimation of distribution position area based on the blood vessel position of single coordinate point to the accuracy and the practicality of the blood vessel position of microvessel are further improved.
On the basis of the above embodiment, when the at least two photodetectors respectively acquire that the first reflected light signals are periodic signals, it is determined whether there is an overlapping region at the blood vessel positions respectively corresponding to the at least two photodetectors, and if so, the coordinate position range corresponding to the overlapping region is taken as the blood vessel position of the microvasculature with the highest priority.
The arrangement has the advantage that the probability of blood vessels existing in the coordinate position range corresponding to the overlapping area is the highest, so that the coordinate position range corresponding to the overlapping area is taken as the blood vessel position of the microvasculature with the highest priority, more accurate position information of the microvasculature can be provided for medical operation, and the incidence rate of iatrogenic vascular injury can be further reduced.
And S250, acquiring first reflected light intensity and second reflected light intensity respectively corresponding to the first reflected light signal and the second reflected light signal acquired by the photoelectric detector aiming at each photoelectric detector.
Wherein, for example, the first reflected light intensity may be l'λ1Wherein the second reflected light intensity may be represented by l'λ2Where λ 1 and λ 2 represent a first preset wavelength and a second preset wavelength, respectively.
And S260, determining the blood oxygen concentration variation of the measured object at the detection depth corresponding to the photoelectric detector based on the first reflected light intensity and the second reflected light intensity.
In the present embodiment, the blood oxygen concentration variation includes oxyhemoglobin (HbO)2) The amount of change in concentration and the amount of change in the concentration of deoxyhemoglobin (HHb).
Wherein, for example, the first reflected light intensity and the first incident light intensity satisfy the formula:
wherein, for example, the second reflected light intensity and the second incident light intensity satisfy the following formula:
wherein, Iλ1(t) and Iλ2(t) respectively representing a first incident light intensity and a second incident light intensity at time t,
and
respectively represent HbO under first incident light with a first preset wavelength lambda 12And HHb respectively correspond to the optical absorption coefficients,
and
respectively represent HbO under second incident light with a second preset wavelength lambda 22And HHb respectively correspond to the optical absorption coefficients,
and
HbO at time t2Concentration and HHb concentration, r represents the component distance between the light source and the photodetector, and DPF represents a weighting factor for the component distance r, called the differential path factor, Gλ1Indicating that the measured object is except HbO under the first incident light with the first preset wavelength lambda 12And HHb tissue light absorption, Gλ2Indicating that the measured object has HbO at the second incident light with the second preset wavelength lambda 22And HHb tissue light absorption.
Wherein, Gλ1And Gλ2For unknown parameters, it is usually assumed that Gλ1And Gλ2Does not vary with time, therefore, an equation is constructed based on the first reflected light intensity and the second reflected light intensity at the last time instant (t-1):
by solving the 4 formulas, the concentration variation of the oxygenated hemoglobin can be obtained
And amount of change in deoxygenated hemoglobin concentration
According to the technical scheme, the light source in the signal acquisition signal is controlled to irradiate the measured object based on the second preset wavelength, the second reflected light signals acquired by at least two photodetectors in the signal acquisition array are acquired, the first reflected light intensity and the second reflected light intensity corresponding to the first reflected light signal and the second reflected light signal acquired by the photodetectors are acquired for each photodetector, and the blood oxygen concentration variation of the measured object at the detection depth corresponding to the photodetectors is determined based on the first reflected light intensity and the second reflected light intensity.
EXAMPLE III
Fig. 6 is a schematic structural diagram of a microvascular location detection apparatus according to a third embodiment of the present invention. As shown in fig. 6, the apparatus includes: a first reflected light signal acquisition module 310, a target assembly distance determination module 320, and a vessel location determination module 330.
The first reflected light signal acquisition module 310 is configured to, in response to detecting a trigger instruction, control a light source in the signal acquisition array to illuminate the measured object based on a first preset wavelength, and acquire first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array; wherein, the light source in the signal acquisition array is linearly arranged with each photoelectric detector;
a target component distance determining module 320, configured to, for each photodetector, take a component distance between the photodetector and the light source as a target component distance when the first reflected light signal acquired by the photodetector is a periodic signal;
a blood vessel position determining module 330, configured to determine a blood vessel position of the micro blood vessel based on the target component distance and the detection depth corresponding to the photodetector; the detection depth meter characteristic signal acquisition array is arranged at the position corresponding to the depth of the measured object in the direction.
According to the technical scheme of the embodiment, the light source in the signal acquisition array is controlled to irradiate the object to be measured based on the first preset wavelength in response to the detection of the trigger instruction, the first reflected light signals acquired by at least two photodetectors in the signal acquisition array are acquired, wherein the light source in the signal acquisition array and each photodetector are linearly arranged, for each photodetector, under the condition that the first reflected light signal acquired by the photodetector is a periodic signal, the assembly distance between the photodetector and the light source is taken as the target assembly distance, and the position of the blood vessel is determined based on the target assembly distance and the detection depth corresponding to the photodetector.
On the basis of the above embodiment, optionally, the apparatus further includes:
the blood flow beating signal determining module is used for inputting the first reflected light signal acquired by the photoelectric detector into the preamplifier and inputting the output amplified reflected light signal into the analog-to-digital converter aiming at each photoelectric detector;
the digital reflected light signal output by the analog-to-digital converter is input into the data processing module to obtain an output blood flow pulse signal, and the first reflected light signal is set as a periodic signal under the condition that the blood flow pulse signal has periodicity.
On the basis of the foregoing embodiment, optionally, the blood vessel position determining module 330 is specifically configured to:
constructing a space coordinate system based on the light source position corresponding to the light source in the signal acquisition array;
and determining the position of the blood vessel of the micro blood vessel in the space coordinate system based on the target component distance and the detection depth corresponding to the photoelectric detector.
On the basis of the foregoing embodiment, optionally, the apparatus further includes:
the detection depth determining module is used for inputting the component distance corresponding to the light source and the photoelectric detector into the analog simulation system aiming at each photoelectric detector in the signal acquisition array;
and taking the output maximum average penetration depth as the corresponding detection depth of the photoelectric detector.
On the basis of the above embodiment, optionally, the apparatus further includes:
the blood oxygen concentration variation determining module is used for controlling a light source in the signal acquisition signal to irradiate the measured object based on a second preset wavelength and acquiring second reflected light signals respectively acquired by at least two photoelectric detectors in the signal acquisition array;
acquiring first reflected light intensity and second reflected light intensity respectively corresponding to a first reflected light signal and a second reflected light signal acquired by a photoelectric detector for each photoelectric detector;
determining the blood oxygen concentration variation of the measured object at the detection depth corresponding to the photoelectric detector based on the first reflected light intensity and the second reflected light intensity; wherein, the blood oxygen concentration variation comprises oxygen-containing hemoglobin concentration variation and deoxyhemoglobin concentration variation.
The device for detecting the position of the microvasculature provided by the embodiment of the invention can execute the method for detecting the position of the microvasculature provided by any embodiment of the invention, and has corresponding functional modules and beneficial effects of the execution method.
Example four
Fig. 7 is a schematic structural diagram of a system for detecting a position of a microvascular vessel according to a fourth embodiment of the present invention. The system may provide a service for the method for detecting a location of a microvascular provided in the above embodiment, and may configure the device for detecting a location of a microvascular provided in the above embodiment. The components of the microvascular location detection system, their connections and relationships, and their functions, illustrated in embodiments of the present invention, are meant to be examples only, and are not intended to limit implementations of the invention described and/or claimed herein.
As shown in fig. 7, the system includes: a signal acquisition array 410 and a controller 420; the signal acquisition array 410 is provided with a light source 411 and at least two photodetectors 412, and the light source 411 and each photodetector 412 are linearly arranged; the controller includes at least one processor 421 and a memory 422 communicatively coupled to the at least one processor 421.
Specifically, the signal collecting array 410 includes a mounting plate, and at least two photodetectors 412 may be both mounted on one side of the light source 411 or on both sides of the light source 411. The distances between the two components in the signal acquisition array 410 may be the same or different. The two components may be the light source 411 and the photodetector 412, or the photodetector 412 and the photodetector 412.
In an alternative embodiment, the assembly distance between different detectors and the light source 411 is an integer multiple of d. Wherein, the user can customize the parameter value of d according to the actual demand. The advantage of setting up like this is that the complexity of the vascular position that provides medical operating personnel can be reduced to regular subassembly distance to make medical operating personnel in time and accurate grasp the vascular position of microvessel.
In an alternative embodiment, the light source 411 in the signal collecting array 410 is a photodiode or a laser light source 411, and when the light source 411 is the laser light source 411, the system further includes: a laser for emitting laser light, a fiber coupler for transmitting the received laser light into the fiber, and a fiber for transmitting the laser light into the laser light source 411.
In an alternative embodiment, the core diameter of the optical fiber is no more than 250 μm, and the photosensitive area of the photodetector 412 is less than 0.25m2. Illustratively, the optical fiber, the light source 411 and the photodetector 412 are packaged together to form a sensor at the front end. This has the advantage that in a medical procedure scenario, the spatial extent over which the signal acquisition array 410 can be placed is typically relatively small, and therefore the volume requirement for the signal acquisition array is relatively high. The embodiment can ensure the accuracy of the position of the blood vessel, reduce the volume of the signal acquisition array 410 as much as possible, and meet the requirement of the medical operation scene on the volume of the signal acquisition array 410.
In an optional embodiment, the system further comprises: the blood flow pulsation signal processing device comprises a preamplifier, an analog-to-digital converter and a data processing module, wherein the preamplifier is used for outputting an amplified reflected light signal based on an input first reflected light signal, the analog-to-digital converter is used for outputting a digital reflected light signal based on the input amplified reflected light signal, and the data processing module is used for outputting a blood flow pulsation signal based on the input digital reflected light signal.
Wherein the memory 422 stores a computer program executable by the at least one processor 421, the processor 421 may perform various suitable actions and processes according to the computer program stored in a Read Only Memory (ROM) or loaded from a storage unit into a Random Access Memory (RAM). In the RAM, various programs and data required for the operation of the controller 420 may also be stored. The processor 421, ROM, and RAM are connected to each other by a bus.
Processor 421 can be a variety of general-purpose and/or special-purpose processing components having processing and computing capabilities. Some examples of processor 421 include, but are not limited to, a Central Processing Unit (CPU), a Graphics Processing Unit (GPU), various dedicated Artificial Intelligence (AI) computing chips, various processors running machine learning model algorithms, a Digital Signal Processor (DSP), and any suitable processor, controller, microcontroller, and so forth. The processor 421 performs the various methods and processes described above, such as a location detection method of a microvascular.
Various implementations of the systems and techniques described here above may be implemented in digital electronic circuitry, integrated circuitry, field Programmable Gate Arrays (FPGAs), application Specific Integrated Circuits (ASICs), application Specific Standard Products (ASSPs), system on a chip (SOCs), load programmable logic devices (CPLDs), computer hardware, firmware, software, and/or combinations thereof. These various embodiments may include: implemented in one or more computer programs that are executable and/or interpretable on a programmable system including at least one programmable processor, which may be special or general purpose, receiving data and instructions from, and transmitting data and instructions to, a storage system, at least one input device, and at least one output device.
Fig. 8 is a schematic structural diagram of a specific example of a system for detecting a position of a microvascular vessel according to a fourth embodiment of the present invention. Specifically, the system for detecting the position of the microvasculature illustrated in fig. 8 includes a laser for emitting 650nm wavelength laser, a laser for emitting 1064nm wavelength laser, a transmitting mirror, a signal acquisition array, a fiber coupler, a controller, a preamplifier, an analog-to-digital converter, a data processor and a display.
The controller can be used to control the opening and closing of the shutter of any laser. Specifically, the controller selects a laser of any incident light wavelength and controls the shutter of the laser to open in response to detecting a trigger instruction. The laser enters the light coupler through the reflection of the two reflectors, then is transmitted in the optical fiber and enters the laser light source in the signal acquisition array, and the laser light source emits incident light to irradiate the measured object. At least two photoelectric detectors in the signal acquisition array respectively acquire first reflected light signals, and after the first reflected light signals sequentially pass through the preamplifier, the analog-to-digital converter and the data processing module, at least two blood flow pulsation signals output by the data processing module are obtained, and the blood flow pulsation signals are respectively displayed on a display in real time.
The system for detecting the position of the microvasculature provided by the embodiment solves the problem that the position of the microvasculature cannot be ascertained by a traditional blood vessel detection method, provides accurate position information of the microvasculature for medical operation, and can further reduce the incidence of iatrogenic vascular injury.
EXAMPLE five
An embodiment of the present invention further provides a computer-readable storage medium, where computer instructions are stored, and the computer instructions are used to enable a processor to execute a method for detecting a location of a microvascular, where the method includes:
responding to the detection of a trigger instruction, controlling a light source in a signal acquisition array to irradiate a measured object based on a first preset wavelength, and acquiring first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array; wherein, the light source and each photoelectric detector in the signal acquisition array are arranged linearly;
for each photoelectric detector, taking the assembly distance between the photoelectric detector and the light source as the target assembly distance under the condition that the first reflected light signal acquired by the photoelectric detector is a periodic signal;
determining the position of the blood vessel of the micro blood vessel based on the target component distance and the detection depth corresponding to the photoelectric detector; wherein, the detection depth table characteristic signal acquisition array is relative to the depth position of the measured object direction.
In the context of the present invention, a computer-readable storage medium may be a tangible medium that can contain, or store a computer program for use by or in connection with an instruction execution system, apparatus, or device. A computer readable storage medium may include, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any suitable combination of the foregoing. Alternatively, the computer readable storage medium may be a machine readable signal medium. More specific examples of a machine-readable storage medium would include an electrical connection based on one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.
To provide for interaction with a user, the systems and techniques described here can be implemented on an electronic device having: a display device (e.g., a CRT (cathode ray tube) or LCD (liquid crystal display) monitor) for displaying information to a user; and a keyboard and a pointing device (e.g., a mouse or a trackball) by which a user can provide input to the electronic device. Other kinds of devices may also be used to provide for interaction with a user; for example, feedback provided to the user can be any form of sensory feedback (e.g., visual feedback, auditory feedback, or tactile feedback); and input from the user may be received in any form, including acoustic, speech, or tactile input.
The systems and techniques described here can be implemented in a computing system that includes a back-end component (e.g., as a data server), or that includes a middleware component (e.g., an application server), or that includes a front-end component (e.g., a user computer having a graphical user interface or a web browser through which a user can interact with an implementation of the systems and techniques described here), or any combination of such back-end, middleware, or front-end components. The components of the system can be interconnected by any form or medium of digital data communication (e.g., a communication network). Examples of communication networks include: local Area Networks (LANs), wide Area Networks (WANs), blockchain networks, and the internet.
The computing system may include clients and servers. A client and server are generally remote from each other and typically interact through a communication network. The relationship of client and server arises by virtue of computer programs running on the respective computers and having a client-server relationship to each other. The server can be a cloud server, also called a cloud computing server or a cloud host, and is a host product in a cloud computing service system, so that the defects of high management difficulty and weak service expansibility in the traditional physical host and VPS service are overcome.
It should be understood that various forms of the flows shown above, reordering, adding or deleting steps, may be used. For example, the steps described in the present invention may be executed in parallel, sequentially, or in different orders, and are not limited herein as long as the desired results of the technical solution of the present invention can be achieved.
The above-described embodiments should not be construed as limiting the scope of the invention. It should be understood by those skilled in the art that various modifications, combinations, sub-combinations and substitutions may be made in accordance with design requirements and other factors. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A method for detecting a position of a microvascular vessel, comprising:
responding to the detection of a trigger instruction, controlling a light source in a signal acquisition array to irradiate the measured object based on a first preset wavelength, and acquiring first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array; the light sources in the signal acquisition array and the photodetectors are linearly arranged;
for each photoelectric detector, taking a component distance between the photoelectric detector and the light source as a target component distance when a first reflected light signal acquired by the photoelectric detector is a periodic signal;
determining the position of the blood vessel of the micro blood vessel based on the target component distance and the detection depth corresponding to the photoelectric detector; wherein the detection depth represents the depth position of the signal acquisition array relative to the direction of the measured object.
2. The method of claim 1, further comprising:
for each photoelectric detector, inputting a first reflected light signal collected by the photoelectric detector into a preamplifier, and inputting an output amplified reflected light signal into an analog-to-digital converter;
and inputting the digital reflected light signal output by the analog-to-digital converter into a data processing module to obtain an output blood flow pulse signal, and setting the first reflected light signal as a periodic signal when the blood flow pulse signal has periodicity.
3. The method of claim 1, wherein determining a vessel location of a microvasculature based on the target assembly distance and a corresponding detection depth of the photodetector comprises:
constructing a space coordinate system based on the light source position corresponding to the light source in the signal acquisition array;
and determining the position of the micro-blood vessel in the space coordinate system based on the target component distance and the corresponding detection depth of the photoelectric detector.
4. The method of claim 1, further comprising:
for each photoelectric detector in the signal acquisition array, inputting the component distance corresponding to the light source and the photoelectric detector into an analog simulation system;
and taking the output maximum average penetration depth as the corresponding detection depth of the photoelectric detector.
5. The method according to any one of claims 1-4, further comprising:
based on a second preset wavelength, controlling a light source in the signal acquisition signal to irradiate the measured object, and acquiring second reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array;
aiming at each photoelectric detector, acquiring first reflected light intensity and second reflected light intensity which respectively correspond to a first reflected light signal and a second reflected light signal acquired by the photoelectric detector;
determining the blood oxygen concentration variation of the measured object at the detection depth corresponding to the photoelectric detector based on the first reflected light intensity and the second reflected light intensity; wherein the blood oxygen concentration variation comprises an oxygen-containing hemoglobin concentration variation and a deoxygenated hemoglobin concentration variation.
6. A microvascular position detection apparatus comprising:
the first reflected light signal acquisition module is used for responding to the detection of a trigger instruction, controlling a light source in the signal acquisition array to irradiate the measured object based on a first preset wavelength, and acquiring first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array; the light sources in the signal acquisition array and the photodetectors are linearly arranged;
a target component distance determination module, configured to, for each photodetector, take a component distance between the photodetector and the light source as a target component distance when a first reflected light signal acquired by the photodetector is a periodic signal;
the blood vessel position determining module is used for determining the blood vessel position of the micro blood vessel based on the target component distance and the detection depth corresponding to the photoelectric detector; wherein the detection depth represents the depth position of the signal acquisition array relative to the direction of the measured object.
7. A microvascular location detection system comprising: a signal acquisition array and a controller;
the signal acquisition array is provided with a light source and at least two photoelectric detectors, and the light source and each photoelectric detector are linearly arranged;
at least one processor and a memory communicatively connected to the at least one processor are included in the controller, the memory storing a computer program executable by the at least one processor, the computer program being executable by the at least one processor to enable the at least one processor to perform the method of location detection of a microvascular as set forth in any one of claims 1-5.
8. The system of claim 7, further comprising: the blood flow pulsation signal detection device comprises a preamplifier, an analog-to-digital converter and a data processing module, wherein the preamplifier is used for outputting an amplified reflected light signal based on an input first reflected light signal, the analog-to-digital converter is used for outputting a digital reflected light signal based on the input amplified reflected light signal, and the data processing module is used for outputting a blood flow pulsation signal based on the input digital reflected light signal.
9. The system of claim 7, wherein the light sources in the signal acquisition array are photodiodes or laser light sources, and when the light sources are laser light sources, the system further comprises: the laser comprises a laser, an optical fiber coupler and an optical fiber, wherein the laser is used for emitting laser, the optical fiber coupler is used for conveying the received laser to the optical fiber, and the optical fiber is used for transmitting the laser to the laser light source.
10. A computer-readable storage medium, having stored thereon computer instructions for causing a processor to execute a method for detecting a location of a microvascular as defined in any of claims 1-5.
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| CN202210883703.8A CN115251853A (en) | 2022-07-26 | 2022-07-26 | Method, device and system for detecting position of microvascular and storage medium |
| PCT/CN2022/132432 WO2024021373A1 (en) | 2022-07-26 | 2022-11-17 | Microvascular position detection method, apparatus and system, and storage medium |
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| CN202210883703.8A CN115251853A (en) | 2022-07-26 | 2022-07-26 | Method, device and system for detecting position of microvascular and storage medium |
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| WO2024021373A1 (en) * | 2022-07-26 | 2024-02-01 | 中国科学院深圳先进技术研究院 | Microvascular position detection method, apparatus and system, and storage medium |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0921477D0 (en) * | 2009-12-08 | 2010-01-20 | Moor Instr Ltd | Apparatus for measuring blood parameters |
| CN106442406A (en) * | 2016-11-25 | 2017-02-22 | 佛山科学技术学院 | Device and method for detecting blood oxygen saturation based on dual-wavelength lasers |
| EP3342337B1 (en) * | 2016-12-29 | 2020-11-04 | Nokia Technologies Oy | Sensor arrangement for a physiological measurement sensor |
| KR102531994B1 (en) * | 2017-12-29 | 2023-05-15 | 삼성전자주식회사 | Apparatus and method for measuring biological components |
| CN109620134B (en) * | 2019-01-21 | 2020-05-22 | 浙江大学 | Micro-angiography method and system based on optical fiber array multi-channel parallel detection |
| CN109700436A (en) * | 2019-01-28 | 2019-05-03 | 广东唯仁医疗科技有限公司 | A kind of Dermal microvessel form and blood flow detection device |
| CN114504315A (en) * | 2022-01-26 | 2022-05-17 | 中国科学院深圳先进技术研究院 | Myooxygen detection method, myooxygen recovery method and system |
| CN115251853A (en) * | 2022-07-26 | 2022-11-01 | 中国科学院深圳先进技术研究院 | Method, device and system for detecting position of microvascular and storage medium |
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| WO2024021373A1 (en) * | 2022-07-26 | 2024-02-01 | 中国科学院深圳先进技术研究院 | Microvascular position detection method, apparatus and system, and storage medium |
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