CN115232399A - Medical polypropylene material and preparation method thereof - Google Patents
Medical polypropylene material and preparation method thereof Download PDFInfo
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- CN115232399A CN115232399A CN202210894858.1A CN202210894858A CN115232399A CN 115232399 A CN115232399 A CN 115232399A CN 202210894858 A CN202210894858 A CN 202210894858A CN 115232399 A CN115232399 A CN 115232399A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/10—Homopolymers or copolymers of propene
- C08L23/12—Polypropene
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Abstract
The invention discloses a medical polypropylene material and a preparation method thereof. The composition is prepared from the following components in parts by weight: 50-100 parts of polypropylene, 5-15 parts of mineral filler, 10-20 parts of high molecular copolymer, 0.1-0.5 part of antioxidant, 1-8 parts of toughening agent and 1-5 parts of lubricant. The medical polypropylene material prepared by the invention is added with the mineral filler of the muscovite and the gunite, so that the mechanical property of the material is enhanced, the transparency of the material under the condition of continuous environmental oxidation is increased, the polymer is added, the low-particle substances of the material are reduced, and the safety of the material is enhanced.
Description
Technical Field
The invention belongs to the technical field of medical material preparation, and particularly relates to a medical polypropylene material and a preparation method thereof.
Background
Polypropylene, PP for short, is a colorless, odorless, nontoxic and semitransparent solid substance. Polypropylene is a thermoplastic synthetic resin with excellent performance, and is colorless translucent thermoplastic light general-purpose plastic. The polypropylene has chemical resistance, heat resistance, electrical insulation, high-strength mechanical property, good high-wear-resistance processing property and the like, so that the polypropylene is rapidly and widely developed and applied in a plurality of fields such as machinery, automobiles, electronic appliances, buildings, textiles, packaging, agriculture, forestry, fishery, food industry and the like since the coming out.
The polypropylene material has excellent performance, is widely applied to the medical field through modification, and is used as a preparation raw material of medical equipment, infusion bags, syringes and the like. The medical material prepared from the polypropylene medical material has various defects, such as poor mechanical property, poor transparency after disinfection, easy precipitation of low-particulate matters, and harm to human health caused by absorption by people. For example, when injection molding the composite closure is performed in a pharmaceutical factory, the containers for temporary packaging are often made of modified polypropylene, which may cause particle contamination of the composite closure during the process.
Disclosure of Invention
The invention aims to provide a medical polypropylene material and a preparation method thereof.
The medical polypropylene material is prepared from the following components in parts by weight: 50-100 parts of polypropylene, 5-15 parts of mineral filler, 10-20 parts of high polymer copolymer, 0.1-0.5 part of antioxidant, 1-8 parts of toughening agent and 1-5 parts of lubricant.
The mineral filler is muscovite and gunite according to a mass ratio of 1:1, mixing the mixture.
The high-molecular copolymer is prepared from styrene-pentadiene-styrene block copolymer and poly-L-lactide-carbamate-polybutadiene block copolymer according to the mass ratio of 1:1, mixing the mixture.
The antioxidant is one or a combination of 7-methoxyl rosmarinci phenol, tetra [ beta- (3,5-di-tert-butyl-4-hydroxyphenyl) propionic acid ] pentaerythritol ester, tri [2, 4-di-tert-butylphenyl ] phosphite ester and antioxidant 1010.
The toughening agent is one or a composition of more of butadiene rubber, ethylene-octene copolymer, ethylene-butene copolymer and acrylonitrile-butadiene-styrene copolymer.
The lubricant is one or a composition of more of oleamide, amide wax, calcium stearate, magnesium stearate and oxidized polyethylene wax.
The preparation method of the medical polypropylene material comprises the following steps:
(1) According to the weight portion, 50-100 portions of polypropylene, 5-15 portions of mineral filler and 10-20 portions of high molecular copolymer are uniformly mixed and added into an extruder to be melted and kneaded at the temperature of 120-220 ℃;
(2) Adding 0.1-0.5 part of antioxidant, 1-8 parts of toughening agent and 1-5 parts of lubricant into an extruder, continuously extruding, cooling by water, and granulating to obtain the medical polypropylene material.
The invention has the beneficial effects that: the medical polypropylene material prepared by the invention is added with the mineral filler of the muscovite and the gunite, so that the mechanical property of the material is enhanced, the transparency of the material under the condition of continuous environmental oxidation is increased, the polymer is added, the low-particle substances of the material are reduced, and the safety of the material is enhanced.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Example 1
The medical polypropylene material is prepared from the following components in parts by weight: 80 parts of polypropylene, 10 parts of mineral filler, 16 parts of high-molecular copolymer, 0.4 part of 7-methoxy rosmarinic phenol, 5 parts of ethylene-octene copolymer and 3 parts of magnesium stearate; the mineral filler is muscovite and gunite according to a mass ratio of 1:1, mixing the mixture; the high-molecular copolymer is a styrene-pentadiene-styrene block copolymer and a poly-L-lactide-carbamate-polybutadiene block copolymer according to a mass ratio of 1:1, mixing the mixture.
The preparation method of the medical polypropylene material comprises the following steps:
(1) According to the weight portion, 80 portions of polypropylene, 10 portions of mineral filler and 16 portions of high molecular copolymer are taken and evenly mixed, and then the mixture is added into an extruder to be melted and kneaded at the temperature of 160 ℃;
(2) And adding 0.4 part of 7-methoxy rosmarinic phenol, 5 parts of ethylene-octene copolymer and 3 parts of magnesium stearate into an extruder, continuously extruding, cooling by water, and granulating to obtain the medical polypropylene material.
Example 2
The medical polypropylene material is prepared from the following components in parts by weight: 55 parts of polypropylene, 6 parts of mineral filler, 12 parts of high-molecular copolymer, 0.1 part of tetra [ beta- (3,5-di-tert-butyl-4-hydroxyphenyl) propionic acid ] pentaerythritol ester, 2 parts of ethylene-butylene copolymer and 1 part of oxidized polyethylene wax; the mineral filler is muscovite and gunite according to a mass ratio of 1:1, mixing the mixture; the high-molecular copolymer is prepared from styrene-pentadiene-styrene block copolymer and poly-L-lactide-carbamate-polybutadiene block copolymer according to the mass ratio of 1:1, mixing the mixture.
The preparation method of the medical polypropylene material comprises the following steps:
(1) According to the weight portion, 55 portions of polypropylene, 6 portions of mineral filler and 12 portions of high molecular copolymer are uniformly mixed and added into an extruder to be melted and kneaded at the temperature of 130 ℃;
(2) Adding 0.1 part of tetra [ beta- (3,5-di-tert-butyl-4-hydroxyphenyl) propionic acid ] pentaerythritol ester, 2 parts of ethylene-butylene copolymer and 1 part of oxidized polyethylene wax into an extruder, continuously extruding, cooling by water, and granulating to obtain the medical polypropylene material.
Example 3
The medical polypropylene material is prepared from the following components in parts by weight: 100 parts of polypropylene, 14 parts of mineral filler, 20 parts of high-molecular copolymer, 0.5 part of tris [ 2.4-di-tert-butylphenyl ] phosphite, 8 parts of acrylonitrile-butadiene-styrene copolymer and 5 parts of amide wax; the mineral filler is muscovite and gunite according to a mass ratio of 1:1, mixing the mixture; the high-molecular copolymer is a styrene-pentadiene-styrene block copolymer and a poly-L-lactide-carbamate-polybutadiene block copolymer according to a mass ratio of 1:1, mixing the mixture.
The preparation method of the medical polypropylene material comprises the following steps:
(1) According to the weight portion, 100 portions of polypropylene, 14 portions of mineral filler and 20 portions of high molecular copolymer are uniformly mixed and added into an extruder to be melted and kneaded at the temperature of 210 ℃;
(2) And adding 0.5 part of tris [2, 4-di-tert-butylphenyl ] phosphite, 8 parts of acrylonitrile-butadiene-styrene copolymer and 5 parts of amide wax into an extruder, and carrying out continuous extrusion, water cooling and grain cutting to obtain the medical polypropylene material.
Comparative example 1
The medical polypropylene material is prepared from the following components in parts by weight: 80 parts of polypropylene, 10 parts of muscovite, 16 parts of high-molecular copolymer, 0.4 part of 7-methoxy rosmarinic phenol, 5 parts of ethylene-octene copolymer and 3 parts of magnesium stearate; the high-molecular copolymer is a styrene-pentadiene-styrene block copolymer and a poly-L-lactide-carbamate-polybutadiene block copolymer according to a mass ratio of 1:1, mixing the mixture.
The preparation method of the medical polypropylene material comprises the following steps:
(1) According to the weight portion, 80 portions of polypropylene, 10 portions of muscovite and 16 portions of high molecular copolymer are taken and evenly mixed, and then the mixture is added into an extruder to be melted and kneaded at the temperature of 160 ℃;
(2) Adding 0.4 part of 7-methoxyl rosmarinic phenol, 5 parts of ethylene-octene copolymer and 3 parts of magnesium stearate into an extruder, continuously extruding, cooling with water, and granulating to obtain the medical polypropylene material.
Comparative example 2
The medical polypropylene material is prepared from the following components in parts by weight: 80 parts of polypropylene, 10 parts of gunite, 16 parts of high-molecular copolymer, 0.4 part of 7-methoxy rosmarinic phenol, 5 parts of ethylene-octene copolymer and 3 parts of magnesium stearate; the high-molecular copolymer is prepared from styrene-pentadiene-styrene block copolymer and poly-L-lactide-carbamate-polybutadiene block copolymer according to the mass ratio of 1:1, mixing the mixture.
The preparation method of the medical polypropylene material comprises the following steps:
(1) According to the weight portion, 80 portions of polypropylene, 10 portions of gunite and 16 portions of high molecular copolymer are uniformly mixed and added into an extruder to be melted and kneaded at the temperature of 160 ℃;
(2) And adding 0.4 part of 7-methoxy rosmarinic phenol, 5 parts of ethylene-octene copolymer and 3 parts of magnesium stearate into an extruder, continuously extruding, cooling by water, and granulating to obtain the medical polypropylene material.
Comparative example 3
The medical polypropylene material is prepared from the following components in parts by weight: 80 parts of polypropylene, 10 parts of mineral filler, 16 parts of styrene-pentadiene-styrene block copolymer, 0.4 part of 7-methoxy rosmarinic phenol, 5 parts of ethylene-octene copolymer and 3 parts of magnesium stearate; the mineral filler is muscovite and gunite according to a mass ratio of 1:1, mixing the mixture.
The preparation method of the medical polypropylene material comprises the following steps:
(1) According to parts by weight, 80 parts of polypropylene, 10 parts of mineral filler and 16 parts of styrene-pentadiene-styrene segmented copolymer are uniformly mixed and added into an extruder to be melted and kneaded at the temperature of 160 ℃;
(2) And adding 0.4 part of 7-methoxy rosmarinic phenol, 5 parts of ethylene-octene copolymer and 3 parts of magnesium stearate into an extruder, continuously extruding, cooling by water, and granulating to obtain the medical polypropylene material.
Comparative example 4
The medical polypropylene material is prepared from the following components in parts by weight: 80 parts of polypropylene, 10 parts of mineral filler, 16 parts of poly-L-lactide-urethane-polybutadiene block copolymer, 0.4 part of 7-methoxy rosmarinic phenol, 5 parts of ethylene-octene copolymer and 3 parts of magnesium stearate; the mineral filler is muscovite and gunite according to a mass ratio of 1:1, mixing the mixture.
The preparation method of the medical polypropylene material comprises the following steps:
(1) According to the weight portion, 80 portions of polypropylene, 10 portions of mineral filler and 16 portions of poly-L-lactide-urethane-polybutadiene segmented copolymer are uniformly mixed, added into an extruder and melted and kneaded at the temperature of 160 ℃;
(2) And adding 0.4 part of 7-methoxy rosmarinic phenol, 5 parts of ethylene-octene copolymer and 3 parts of magnesium stearate into an extruder, continuously extruding, cooling by water, and granulating to obtain the medical polypropylene material.
Experimental example:
the medical polypropylene materials prepared in examples 1-3 and comparative examples 1-2 were tested for tensile strength and elongation at break according to ISO 527, and the results are shown in Table 1:
TABLE 1
Note: * Represents P <0.05 compared to the example 1 group.
Insoluble particle determination: the sample was injection molded into a strip of 80mm length, 10mm width and 4mm thickness and placed in a sample bottle. 10 specimens and 100ml of water were put in each time, shaken at 300rpm for 20 seconds with a shaker, and measured after standing for 6 hours. Before measurement, the sample is oscillated for 20 seconds at 300rpm by an oscillator, within 30min after oscillation, the sample is injected by 10ml each time by using a GWF-7JA particle analyzer, the number of particles in a channel with the diameter of more than or equal to 10 mu m is measured, the average value is taken after each group of experiment measurement is carried out for 3 times, and the measurement result is shown in a table 2:
TABLE 2
Note: * Represents P <0.05 compared to the example 1 group.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is specific and detailed, but not to be understood as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (7)
1. The medical polypropylene material is characterized by being prepared from the following components in parts by weight: 50-100 parts of polypropylene, 5-15 parts of mineral filler, 10-20 parts of high molecular copolymer, 0.1-0.5 part of antioxidant, 1-8 parts of toughening agent and 1-5 parts of lubricant.
2. The medical polypropylene material according to claim 1, wherein the mineral filler is muscovite and barite in a mass ratio of 1:1, mixing the mixture.
3. The medical polypropylene material according to claim 1, wherein the high molecular copolymer is a styrene-pentadiene-styrene block copolymer and a poly-L-lactide-urethane-polybutadiene block copolymer in a mass ratio of 1:1, mixing the mixture.
4. The medical polypropylene material according to claim 1, wherein the antioxidant is one or a combination of 7-methoxy rosmarinic phenol, tetra [ beta- (3,5-di-tert-butyl-4-hydroxyphenyl) propionic acid ] pentaerythritol ester, tris [2, 4-di-tert-butylphenyl ] phosphite, and antioxidant 1010.
5. The medical polypropylene material according to claim 1, wherein the toughening agent is one or a combination of butadiene rubber, ethylene-octene copolymer, ethylene-butene copolymer and acrylonitrile-butadiene-styrene copolymer.
6. The medical polypropylene material according to claim 1, wherein the lubricant is one or a combination of more of oleamide, amide wax, calcium stearate, magnesium stearate and oxidized polyethylene wax.
7. The preparation method of the medical polypropylene material as claimed in claim 1, which is carried out according to the following steps:
(1) Taking 50-100 parts of polypropylene, 5-15 parts of mineral filler and 10-20 parts of high-molecular copolymer according to parts by weight, uniformly mixing, adding into an extruder, and carrying out melt kneading at the temperature of 120-220 ℃;
(2) Adding 0.1-0.5 part of antioxidant, 1-8 parts of toughening agent and 1-5 parts of lubricant into an extruder, continuously extruding, cooling by water, and granulating to obtain the medical polypropylene material.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210894858.1A CN115232399A (en) | 2022-07-28 | 2022-07-28 | Medical polypropylene material and preparation method thereof |
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| CN202210894858.1A CN115232399A (en) | 2022-07-28 | 2022-07-28 | Medical polypropylene material and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104231446A (en) * | 2014-09-25 | 2014-12-24 | 广州市合诚化学有限公司 | Low-particle precipitation medical polypropylene material as well as application and preparation method thereof |
| CN104974418A (en) * | 2014-04-14 | 2015-10-14 | 中国石化扬子石油化工有限公司 | Polyropylene composite material and preparation method thereof |
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- 2022-07-28 CN CN202210894858.1A patent/CN115232399A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104974418A (en) * | 2014-04-14 | 2015-10-14 | 中国石化扬子石油化工有限公司 | Polyropylene composite material and preparation method thereof |
| CN104231446A (en) * | 2014-09-25 | 2014-12-24 | 广州市合诚化学有限公司 | Low-particle precipitation medical polypropylene material as well as application and preparation method thereof |
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