CN115228527A - Device for supporting pipetting and washing apposition operation - Google Patents
Device for supporting pipetting and washing apposition operation Download PDFInfo
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- CN115228527A CN115228527A CN202210969448.9A CN202210969448A CN115228527A CN 115228527 A CN115228527 A CN 115228527A CN 202210969448 A CN202210969448 A CN 202210969448A CN 115228527 A CN115228527 A CN 115228527A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
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Abstract
An apparatus for supporting pipetting and washing apposition operations is disclosed. The device comprises a gantry, a first linear driving device, a second linear driving device, a driving plate, a fixing plate, a push plate and a plurality of air cylinder assemblies; a downward protruding part is arranged at the position, corresponding to the second through hole, of the lower part of the push plate, and the shape of the downward protruding part meets the requirement of installing a magnetic sleeve in a matching manner; the cylinder body of the cylinder component is relatively fixed with the fixed plate and relatively movable with the push plate; the front end of the cylinder body is provided with an opening part, and the appearance of the opening part meets the requirement of installing a suction head in an adaptive manner; the fixed plate can reciprocate under the drive effect of first straight line drive equipment to drive push pedal and drive plate follow the removal, the drive plate can reciprocate under the drive effect of second straight line drive equipment, and drive push pedal follows the removal. The device can realize that move liquid and washing operation are carried out with same set of system at same position to simplify system architecture, practice thrift the cost, raise the efficiency.
Description
Technical Field
The application relates to the technical field of biomedical inspection, in particular to a driving device suitable for liquid transferring and cleaning links.
Background
In recent years, automatic in vitro diagnostic equipment has been widely used in the medical field and scientific research field, for example, patent document CN101334402A discloses a full-automatic biochip detection system, which adopts a modular structure, and includes an automatic sample processing module, a reaction washing module, a detection module, a Tip head storage module, a reagent storage module, a biochip storage module, a sample storage module, a system base, an electric cabinet and the like, so as to realize the processes of automatic sampling, sample adding, reaction, washing, detection and the like.
At present, the application fields such as nucleic acid detection generally relate to move liquid and wash the link, and concretely relates to utilizes suction head (tip head) to absorb sample liquid, shifts to the test tube, withdraws the suction head, utilizes the magnetic sleeve to adsorb the magnetic bead, and then the enrichment sample to carry out the separation processing of shifting, shaking.
In each specific operation link, consumable modules (including sample holes, reaction holes, cleaning holes, detection holes and the like) below the actuating mechanism sequentially move in place along the horizontal direction, so that corresponding hole sites are aligned in the vertical direction, and then the corresponding hole sites are matched with the actuating mechanism to work.
At present, two sets of actuating mechanisms (equipment) are needed in the liquid transferring and cleaning links, the occupied space is large, and the efficiency of the whole treatment process is not ideal enough.
Disclosure of Invention
Therefore, the device supporting pipetting and washing apposition operation is provided to solve the problems that the occupied space is large and the whole process treatment efficiency is not ideal enough in the prior art.
In order to achieve the above purpose, the present application provides the following technical solutions:
a device for supporting pipetting and washing co-location operation comprises a gantry, a first linear driving device, a second linear driving device, a driving plate, a fixing plate, a push plate and a plurality of cylinder assemblies;
the first linear driving device is fixedly arranged at the top of the gantry; the driving plate, the fixing plate and the push plate are sequentially arranged in the door frame from top to bottom, and second linear driving equipment is located above the driving plate and is fixedly connected with the fixing plate; the plurality of air cylinder assemblies are parallel to each other and are vertically arranged in the door frame;
the fixed plate is provided with a plurality of first through holes, the push plate is provided with a plurality of second through holes, and the first through holes and the second through holes correspond to the air cylinder assemblies one by one; a downward protruding part is arranged at the position, corresponding to the second through hole, of the lower part of the push plate, and the shape of the downward protruding part meets the requirement of adapting and installing a magnetic sleeve;
the air cylinder assembly comprises a cylinder body, a push rod and a magnetic rod, the push rod and the magnetic rod are coaxially arranged in the cylinder body and are relatively fixed, and the rear end of the push rod is positioned in the up-and-down movement stroke range of the drive plate;
the cylinder body correspondingly penetrates through the fixed plate and the push plate through the first through hole and the second through hole in sequence, and the cylinder body is fixed relative to the fixed plate and moves relative to the push plate; the front end of the cylinder body is provided with an opening part, the shape of the opening part meets the requirement of installing a suction head in an adaptive mode, and the outer wall of the opening part is in sliding contact with the inner wall of the protruding part of the push plate;
the first linear driving device is used for driving the fixing plate to move up and down, and the driving plate and the push plate move along with the fixing plate when the fixing plate is driven to move up and down through the association structure of the fixing plate, the driving plate and the push plate;
the second linear driving device is used for driving the driving plate to move up and down, and the push plate moves along with the driving plate when the driving plate is driven to move up and down through the correlation structure;
the associated structure comprises at least one group of pressure spring assemblies; the pressure spring assembly comprises a screw rod, a first pressure spring and a second pressure spring, the first pressure spring and the second pressure spring are respectively sleeved on different parts of the screw rod, the screw rod sequentially penetrates through the driving plate, the fixing plate and the push plate from top to bottom, and gaps are kept among the screw rod, the driving plate and the fixing plate; the middle part of the screw rod is provided with an annular boss which is positioned above the fixed plate, and the radial dimension of the annular boss is larger than a hole through which the screw rod on the fixed plate passes; two ends of the first pressure spring are respectively contacted with the driving plate and the annular boss, and two ends of the second pressure spring are respectively contacted with the fixed plate and the push plate; the upper end of the screw rod is hung on the drive plate, and the lower end of the screw rod is fixedly connected with the push plate.
Optionally, a limiting boss is formed in the middle of the cylinder body along the radial direction, and is used for enabling the cylinder body to be matched and limited on the fixing plate.
Optionally, the magnetic bar is a solid magnet.
Optionally, the drive plate has a double-layer structure, the upper end of the screw rod has a radial extension part for being hung at a hole position corresponding to the lower plate of the drive plate, and the upper plate of the drive plate is provided with a notch to leave a space for allowing the upper end of the screw rod to move upwards; the rear end of a push rod of the air cylinder assembly is limited between the upper plate and the lower plate of the driving plate.
Optionally, the screw and the second pressure spring are abutted to the upper surface of the push plate, the push plate is provided with a through hole corresponding to the center of the screw, the diameter of the through hole is smaller than the outer diameter of the screw, and the lower surface of the push plate is provided with a screw which penetrates through the through hole from bottom to top to fixedly connect the screw and the push plate.
Optionally, the compressed spring assemblies are distributed on the installation plane at equal intervals.
Optionally, the main body of the cylinder is divided into two sections, wherein a front section is close to the opening portion, the radial dimension of the front section is smaller than that of a rear section, a gap is maintained between the front section and the second through hole in the radial direction, an annular step surface is formed between the front section and the rear section, and the second through hole can be limited on the upper surface of the push plate.
Optionally, the first linear driving device and the second linear driving device both use linear stepping motors.
Optionally, a hole or a notch corresponding to the position of the second linear driving device is formed in the top of the gantry; and the rear side of the portal is provided with a fixed connecting plate, the upper part of the fixed connecting plate is fixedly connected with the second linear driving device, and the lower part of the fixed connecting plate is fixedly connected with the fixed plate.
Optionally, a guide shaft is vertically fixed in the frame of the gantry, and the guide shaft sequentially penetrates through the drive plate, the fixed plate and the push plate from top to bottom.
Optionally, the first linear driving device is further configured with a photoelectric switch for detecting the driving displacement.
Compared with the prior art, the method has the following beneficial effects:
a driving plate, a fixed plate and a push plate are sequentially arranged in a frame of the portal from top to bottom, the push plate is provided with a downward convex part, and the shape of the push plate meets the requirement of installing a magnetic sleeve in a matching way; the cylinder body of the cylinder component is relatively fixed with the fixed plate and relatively movable with the push plate; the front end of the cylinder body is provided with an opening part, and the shape of the opening part meets the requirement of installing a suction head in an adaptive manner; the fixing plate can move up and down under the driving action of the first linear driving device and drives the push plate, the driving plate and the second linear driving device to move along with the fixing plate, and the driving plate can move up and down under the driving action of the second linear driving device and drives the push plate to move along with the fixing plate; therefore, in the frame of the same gantry, the operation of installing the suction head, removing the suction head, installing the magnetic sleeve, removing the magnetic sleeve and the like is respectively realized by the multiplexing executing mechanism (utilizing different parts of the executing mechanism), the whole structure of the system is compact, the occupied space and the cost are saved, and the whole process treatment efficiency is favorably improved.
Drawings
To more intuitively illustrate the prior art and the present application, several exemplary drawings are given below. It should be understood that the specific shapes, configurations, shown in the drawings, are not generally considered limitations on the practice of the present application; for example, it is within the ability of those skilled in the art to make routine adjustments or further optimizations based on the technical concepts disclosed in the present application and the exemplary drawings, for the increase/decrease/attribution of certain units (components), specific shapes, positional relationships, connection manners, dimensional ratios, and the like.
FIG. 1 is a schematic diagram of an apparatus for supporting pipetting and washing in-situ according to an embodiment of the present application;
FIG. 2 is a front view of the apparatus of the embodiment of FIG. 1;
FIG. 3 is an enlarged view of a portion of FIG. 2 at A;
FIG. 4 is an enlarged view of a portion of FIG. 2 at B;
FIG. 5 is a schematic view of another perspective of an apparatus according to an embodiment of the present application;
FIG. 6 is a schematic view of a cylinder assembly of an apparatus according to an embodiment of the present application in an operating state;
FIG. 7 is a cross-sectional view of the embodiment of the device shown in FIG. 6;
FIG. 8 is a schematic view of a cylinder assembly in another operating condition in an apparatus according to an embodiment of the present application;
FIG. 9 is a cross-sectional view of the embodiment of the device shown in FIG. 8;
FIG. 10 is a schematic view of an embodiment of the apparatus of the present application in an operational state (with the magnetic sleeve in place);
FIG. 11 is a schematic view of the embodiment of FIG. 10 from another perspective;
FIG. 12 is a schematic view of another working state of the apparatus according to an embodiment of the present application (with the suction head mounted in place);
fig. 13 is a schematic view of the embodiment of fig. 12 from another perspective.
Description of the reference numerals:
1. a gantry; 2. a first linear drive device; 3. a second linear drive device; 4. a drive plate; 5. a fixing plate; 6. pushing the plate; 601. a projection; 7. a cylinder assembly; 701. a cylinder body; 7011. a limiting boss; 7012. an opening part; 7013. an annular step surface; 702. a push rod; 703. a magnetic bar; 704. a seal ring; 8. a compression spring assembly; 801. a screw; 802. a first pressure spring; 803. a second pressure spring; 804. a screw; 805. an annular boss; 9. a photoelectric switch; 10. a guide shaft; 11. a linear bearing; 12. a suction head; 13. a magnetic sleeve; 14. and fixing the connecting plate.
Detailed Description
The present application will be described in further detail below with reference to specific embodiments in conjunction with the accompanying drawings.
In the description of the present application: "plurality" means two or more unless otherwise specified. The terms "first", "second", "third", and the like in this application are intended to distinguish one referenced item from another without having a special meaning in technical connotation (e.g., should not be construed as emphasizing a degree or order of importance, etc.). The terms "comprising," "including," "having," and the like, are intended to be inclusive and mean "not limited to" (some elements, components, materials, steps, etc.).
In the present application, terms such as "upper", "lower", "left", "right", "middle", and the like are usually used for the purpose of visual understanding with reference to the drawings, and are not intended to be an absolute limitation of the positional relationship in an actual product. Changes in these relative positional relationships are also considered to be within the scope of the present disclosure without departing from the technical concepts disclosed in the present disclosure.
As shown in fig. 1 to 5, an apparatus for supporting pipetting and washing co-located operation according to an embodiment of the present application comprises a gantry 1, a first linear driving device 2, a second linear driving device 3, a driving plate 4, a fixed plate 5, a push plate 6 and a plurality of cylinder assemblies 7; the first linear driving device 2 is fixedly arranged at the top of the gantry 1; the driving plate 4, the fixing plate 5 and the push plate 6 are sequentially arranged in the gantry 1 from top to bottom, the fixing plate 5 is connected with the output end of the first linear driving device 2, and the second linear driving device 3 is positioned above the driving plate 4 and is fixedly connected with the fixing plate 5; the driving plate 4 is connected with the output end of the second linear driving device 3; the plurality of cylinder assemblies 7 are parallel to each other and are vertically arranged in the portal 1.
The fixed plate 5 is provided with a plurality of first through holes, the push plate 6 is provided with a plurality of second through holes, and the first through holes and the second through holes correspond to the air cylinder assemblies 7 one by one; the lower part of the push plate 6 is provided with a downward convex part 601 corresponding to the second through hole, and the shape of the downward convex part satisfies the shape of the magnetic sleeve 13 which is installed in a matching way, as shown in fig. 10 and fig. 11.
As shown in fig. 6 to 9, the cylinder assembly includes a cylinder body 701, a push rod 702 and a magnetic rod 703, the push rod 702 and the magnetic rod 703 are coaxially arranged in the cylinder body and relatively fixed, and the rear end of the push rod 702 is located within the range of the up-and-down movement stroke of the drive plate 4; in the cylinder 701, a sealing ring 704 can be arranged on the outer wall of the push rod 702 (or the inner wall of the cylinder 701); the cylinder body 701 correspondingly penetrates through the fixed plate 5 and the push plate 6 through the first through hole and the second through hole in sequence, and the cylinder body 701 is relatively fixed with the fixed plate 5 and relatively movable with the push plate 6; an opening 7012 is provided at the front end of the cylinder 701, and the shape of the opening 7012 is adapted to fit the suction head 12, as shown in fig. 12 and 13. Wherein, the inner wall of the opening 7012 can be in sliding contact with the outer wall of the magnetic rod 703 and can also maintain a gap; the outer wall of the opening 7012 is in sliding contact with the inner wall of the protrusion 601 of the push plate.
Fig. 5 is intended to illustrate the basic positional relationship of the drive plate 4, the fixed plate 5, the push plate 6, the cylinder assembly 7, and the pressure spring assembly 8, and is therefore somewhat simplified with respect to fig. 1.
In one embodiment, the specific structure for fixing the cylinder 701 and the fixing plate 5 relatively may be: as shown in fig. 6, a limiting boss 7011 is formed at the middle of the cylinder 701 along the radial direction for allowing the cylinder 701 to be fittingly limited to the fixing plate 5 (a corresponding annular groove may be provided in the fixing plate 5). Of course, other forms may be used, such as a threaded connection, adhesive, etc. The magnetic rod 703 is preferably a solid magnet.
The first linear driving device 2 is used for driving the fixing plate 5 to move up and down (specifically, the output end of the first linear driving device 2 passes through or bypasses the driving plate 4 to be connected with the fixing plate 5), and through the associated structure of the fixing plate 5 and the driving plate 4, the push plate 6, so that when the fixing plate 5 is driven to move up and down, the driving plate 4, the push plate 6 follow the fixing plate 5 to move.
The second linear driving device 3 is used for driving the driving plate 4 to move up and down (specifically, the output end of the second linear driving device 3 is connected with the driving plate 4), and through the aforementioned associated structure, when the driving plate is driven to move up and down, the push plate moves along with the driving plate. When the fixed plate 5 and the cylinder block 701 are held in place, the push rod 702 of the plurality of cylinder assemblies 7 is pushed down by the drive plate 4, whereby the magnetic rod 703 is pushed out from the opening 7012.
In one embodiment, a preferable scheme of the association structure of the fixing plate 5 and the driving plate 4 and the push plate 6 is as follows: set up multiunit pressure spring subassembly 8, multiunit pressure spring subassembly 8 can equidistant distribution on the mounting plane. The pressure spring assembly 8 comprises a screw 801, a first pressure spring 802 and a second pressure spring 803, the screw 801 sequentially penetrates through the drive plate 4, the fixing plate 5 and the push plate 6 from top to bottom, and gaps are kept among the screw 801, the drive plate 4 and the fixing plate 5; an annular boss 805 is arranged in the middle of the screw 801, and a first pressure spring 802 and a second pressure spring 803 are respectively sleeved on a screw section above the annular boss and a screw section below the annular boss, wherein the upper end of the first pressure spring 802 is in contact with the drive plate 4, and the lower end of the first pressure spring 802 is in contact with the annular boss; the upper end of the second pressure spring 803 is contacted with the fixed plate 5, and the lower end is contacted with the driving plate 4; the upper end of the screw 801 is hung on the drive plate 4, and the lower end of the screw 801 is fixedly connected with the push plate 6.
In one embodiment, as shown in fig. 3 in combination, the driving board 4 has a double-layer structure, and the upper board and the lower board are a single piece, and are mainly provided with grooves horizontally formed on the front surface to form an interlayer (gap) between the upper board and the lower board. The upper end of the screw 801 is provided with a radial extension part which is used for hanging in a hole position corresponding to the lower layer plate of the driving plate 4; the radial extension part can be a cylindrical head screw which is nailed in the center of the upper end of the screw 801, the radial size of the cylindrical head meets the requirement of being hung in a hole position corresponding to the lower layer plate of the drive plate 4, or can be a nut which is integrally formed based on the body of the screw 801, and the radial size of the nut meets the requirement of being hung in a hole position corresponding to the lower layer plate of the drive plate 4; other specific structural forms may also be adopted. A gap is formed in an upper plate of the driving plate 4, and a space for enabling the upper end of the screw 801 to move upwards is reserved; the rear end of the push rod 702 of the cylinder assembly 7 is confined between the upper and lower plates of the drive plate 4.
In one embodiment, as shown in fig. 4, the screw 801 and the second compression spring 803 are abutted against the upper surface of the push plate 6, the push plate 6 is provided with a through hole corresponding to the center of the screw 801, the diameter of the through hole is smaller than the outer diameter of the screw 801, the lower surface of the push plate 6 is provided with a screw 804, and as shown in fig. 5, the screw 804 penetrates through the through hole from bottom to top to fixedly connect the screw 801 and the push plate 6.
In one embodiment, the main body of the cylinder is divided into two sections, wherein the front section is close to the opening 7012, the radial dimension of the front section is smaller than that of the rear section, a gap is maintained between the front section and the second through hole in the radial direction, and an annular step surface 7013 is formed between the front section and the rear section and can be limited on the upper surface of the push plate at the second through hole.
As shown in fig. 5, the top of the gantry may be provided with holes or indentations corresponding to the position of the second linear drive device; and a fixed connecting plate 14 is arranged at the rear side of the portal frame, the upper part of the fixed connecting plate 14 is fixedly connected with the second linear driving device 3, and the lower part of the fixed connecting plate 14 is fixedly connected with the fixed plate 5.
As shown in fig. 1, the first linear driving device 2 may further be configured with a photoelectric switch 9 for detecting the driving displacement, so as to feed back in real time, which is beneficial to improving the precision of the control driving.
As shown in fig. 1, a guide shaft 10 is further vertically fixed in the frame of the gantry 1, the guide shaft 10 sequentially penetrates through the drive plate 4, the fixed plate 5 and the push plate 6 from top to bottom, and for the first linear driving device 2 and the second linear driving device 3, a linear bearing 11 can be arranged on the corresponding guide shaft 10, so that the drive plate 4, the fixed plate 5 and the push plate 6 respectively vertically move along the guide shaft, and the protruding portion 601 of the push plate, the opening portion 7012 of the cylinder body and the magnetic rod 703 are ensured to be aligned with the target (magnetic sleeve, suction head) in the vertical direction.
The shape of the suction head is similar to a cone, the shape of the magnetic sleeve is similar to a cylinder, the caliber of the magnetic sleeve is slightly larger than that of the suction head, and the magnetic sleeve has larger elasticity than the suction head. This is also the shape and structural characteristics of the suction head and magnetic sleeve which are conventional at present. The main executing actions of the liquid transferring and cleaning operations are a suction head (mounting the suction head), a suction head withdrawal, a magnetic sleeve (mounting the magnetic sleeve) and a demagnetization sleeve.
The following describes the main operation of the embodiment to perform pipetting and washing:
1. pipetting device
Firstly, the second linear driving device 3 is driven reversely, the driving plate 4 moves upwards, the screw 801 hung on the driving plate 4 is pulled, and then the screw 801 drives the push plate 6 to move upwards, and in the process, because the first linear driving device 2 does not act, the positions of the fixed plate 5 and the air cylinder assembly 7 in the vertical direction do not act, so that the opening portion 7012 of the cylinder body is exposed from the push plate 6;
then, under the forward driving action of the first linear driving device 2, the fixing plate 5 drives the cylinder 701 and the body of the second linear driving device 3 to move downwards, in the process, the fixing plate 5 pushes the push plate 6 to move downwards through the second pressure spring 803, and as the push plate 6 is fixed with the screw 801, the upper end of the screw 801 is hung on the driving plate 4, and the driving plate 4 moves downwards, the push plate 6 and the driving plate 4 move downwards along with the whole fixing plate 5; the suction head 12 is inserted into the opening part 7012 of the cylinder body in a matching way, so that the suction head 12 is installed;
the sample hole moves horizontally to the right position, and under the reverse driving action of the second linear driving device 3, the driving plate 4 moves upwards, so that the push rod 702 of the air cylinder assembly is extracted, and liquid absorption is realized by utilizing the negative pressure effect; the reaction hole moves horizontally to the right position, and under the forward driving action of the second linear driving device 3, the driving plate 4 presses the push rod 702 of the air cylinder assembly to inject liquid, so that the liquid is transferred to the reaction hole to react.
Under the action of the forward driving of the second linear driving device 3, the driving plate 4 moves downwards, the screw 801 moves downwards due to the self-weight of the screw due to the compression of the first compression spring 802, the elastic force preserved before the second compression spring 803 is released, the push plate 6 descends, and the protrusion 601 of the push plate scrapes the suction head, namely, the suction head 12 is removed.
The first linear drive device 2 and the second linear drive device 3 are returned to the drive home positions.
2. Cleaning of
Under the forward driving action of the second linear driving device 3, the driving plate 4 moves downwards to compress the first compression spring 802, so that the screw 801 is driven to move downwards, and the push plate 6 moves downwards to cover the opening 7012 of the cylinder body along with the screw 801, namely, the opening 7012 is completely positioned in the push plate 6 (in the second through hole); in this process, the push rod 702 of the cylinder assembly is also pushed downward, so that the magnetic rod 703 extends forward (downward) a certain distance but remains inside the cylinder (without being exposed from the opening 7012 of the cylinder block), and the cylinder block 701 does not move. Then, under the positive driving action of the first linear driving device 2, the fixed plate 5 drives the cylinder 701 to move downwards, so as to drive the push plate 6 to continue to move downwards until the convex part 601 of the push plate is fittingly inserted into the magnetic sleeve 13, thereby completing the installation of the magnetic sleeve 13.
Next, the magnetic sleeve 13 is extended into the reaction hole to contact with the liquid, under the driving action of the second linear driving device 3, the driving plate 4 presses down the push rod 702 of the air cylinder assembly 7, so that the magnetic rod 703 extends out of the opening 7012 of the cylinder body by a proper length, the magnetic rod 703 is inserted, and then oscillation is performed, and the magnetic beads are adsorbed on the outer wall of the magnetic sleeve;
the transfer magnetic sleeve 13 extends into the first cleaning hole, the magnetic rod 703 retracts under the driving action of the second linear driving device 3, and then the magnetic rod vibrates, so that the originally adsorbed magnetic beads fall into the first cleaning hole, and impurities are washed away; and cleaning twice (sequentially transferring to a second cleaning hole and a third cleaning hole), and finally collecting magnetic beads to enter the detection hole to be used as a sample to be detected.
After the detection hole is formed, under the reverse driving action of the second linear driving device 3, the driving plate 4 moves upwards, the screw 801 hung on the driving plate 4 is pulled, and then the screw 801 drives the push plate 6 to move upwards; since the first linear driving device 2 does not act in this process, and the positions of the fixed plate 5 and the cylinder assembly 7 in the vertical direction are constant, when the push plate 6 moves upwards, the distance that the opening portion 7012 of the cylinder body extends relative to the protrusion 601 at the lower end of the push plate is larger and larger, the opening portion 7012 of the cylinder body exerts a pushing action on the magnetic sleeve mounted on the protrusion 601, and finally the magnetic sleeve falls off from the protrusion 601, thereby completing the demagnetizing sleeve 13.
The device can realize that the same set of system is used for carrying out pipetting and cleaning operations at the same position, thereby simplifying the system structure, saving the cost and improving the efficiency.
The specific processes of the pipetting and cleaning operations relate to the multiple operations of the first linear driving device and the second linear driving device, and for the sake of simplicity of description, only the key operation processes are described. Those skilled in the art will be able to fully understand and implement the above aspects based on existing operating specifications and conventional configurations with reference to the working procedures described herein.
All the technical features of the above embodiments can be arbitrarily combined (as long as there is no contradiction between the combinations of the technical features), and for brevity of description, all the possible combinations of the technical features in the above embodiments are not described; these examples, which are not explicitly described, should be considered to be within the scope of the present description.
The present application has been described in considerable detail with reference to certain embodiments and examples thereof. It should be understood that several general adaptations or further innovations of these specific embodiments can also be made based on the technical idea of the present application; however, such conventional modifications and further innovations can also fall into the scope of the claims of the present application as long as they do not depart from the technical idea of the present application.
Claims (10)
1. The device for supporting pipetting and washing homotopic operation is characterized by comprising a portal frame, a first linear driving device, a second linear driving device, a driving plate, a fixing plate, a push plate and a plurality of air cylinder assemblies;
the first linear driving device is fixedly arranged at the top of the gantry; the driving plate, the fixing plate and the push plate are sequentially arranged in the door frame from top to bottom, and second linear driving equipment is located above the driving plate and is fixedly connected with the fixing plate; the plurality of air cylinder assemblies are parallel to each other and are vertically arranged in the door frame;
the fixed plate is provided with a plurality of first through holes, the push plate is provided with a plurality of second through holes, and the first through holes and the second through holes correspond to the air cylinder assemblies one by one; a downward protruding part is arranged at the position, corresponding to the second through hole, of the lower part of the push plate, and the shape of the downward protruding part meets the requirement of adapting to the installation of a magnetic sleeve;
the air cylinder assembly comprises a cylinder body, a push rod and a magnetic rod, the push rod and the magnetic rod are coaxially arranged in the cylinder body and are relatively fixed, and the rear end of the push rod is positioned in the range of the up-and-down movement stroke of the driving plate;
the cylinder body correspondingly penetrates through the fixed plate and the push plate through the first through hole and the second through hole in sequence, and the cylinder body is fixed relative to the fixed plate and moves relative to the push plate; the front end of the cylinder body is provided with an opening part, the shape of the opening part meets the requirement of installing a suction head in an adaptive mode, and the outer wall of the opening part is in sliding contact with the inner wall of the protruding part of the push plate;
the first linear driving device is used for driving the fixing plate to move up and down, and the driving plate and the push plate move along with the fixing plate when the fixing plate is driven to move up and down through the association structure of the fixing plate, the driving plate and the push plate;
the second linear driving device is used for driving the driving plate to move up and down, and the push plate moves along with the driving plate when the driving plate is driven to move up and down through the correlation structure;
the associated structure comprises at least one group of pressure spring assemblies; the pressure spring assembly comprises a screw rod, a first pressure spring and a second pressure spring, the first pressure spring and the second pressure spring are respectively sleeved on different parts of the screw rod, the screw rod sequentially penetrates through the driving plate, the fixing plate and the push plate from top to bottom, and gaps are kept among the screw rod, the driving plate and the fixing plate; the middle part of the screw rod is provided with an annular boss, the annular boss is positioned above the fixed plate, and the radial size of the annular boss is larger than a hole through which the screw rod on the fixed plate passes; two ends of the first pressure spring are respectively contacted with the driving plate and the annular boss, and two ends of the second pressure spring are respectively contacted with the fixed plate and the push plate; the upper end of the screw rod is hung on the drive plate, and the lower end of the screw rod is fixedly connected with the push plate.
2. An apparatus for supporting pipetting and washing co-located operations as recited in claim 1 wherein the cylinder body has a radially formed retaining boss at its center for engaging and retaining the cylinder body to the retaining plate.
3. An apparatus for supporting pipetting and washing co-located operations according to claim 1 wherein the magnetic rod is a solid magnet.
4. An apparatus for supporting pipetting and washing co-located operations as recited in claim 1 wherein the drive plate has a double-deck structure, the upper end of the screw has a radial extension for engaging a corresponding hole site on the lower deck of the drive plate, the upper deck of the drive plate is notched to allow room for the upper end of the screw to move upwardly; the rear end of a push rod of the air cylinder assembly is limited between the upper plate and the lower plate of the driving plate.
5. The apparatus for supporting pipetting and washing co-located operation as recited in claim 1, wherein the screw rod and the second compression spring are abutted against the upper surface of the pushing plate, the pushing plate is provided with a through hole corresponding to the center of the screw rod, the diameter of the through hole is smaller than the outer diameter of the screw rod, the lower surface of the pushing plate is provided with a screw, and the screw passes through the through hole from bottom to top to fixedly connect the screw rod and the pushing plate.
6. An apparatus for supporting pipetting and washing co-located operations as recited in claim 1 wherein the compression spring assemblies are in a plurality of sets equally spaced on the mounting plane.
7. An apparatus for supporting pipetting and washing co-located operations according to claim 1, characterized in that: the main body of the cylinder is divided into two sections, wherein the front section is close to the opening part, the radial size of the front section is smaller than that of the rear section, a gap is kept between the front section and the second through hole in the radial direction, an annular step surface is formed between the front section and the rear section, and the second through hole can be limited on the upper surface of the push plate.
8. An apparatus for supporting pipetting and washing co-located operations according to claim 1, wherein the first linear drive device and the second linear drive device each employ linear stepper motors.
9. An apparatus for supporting pipetting and washing co-located operations as recited in claim 1 wherein the top of the gantry defines a hole or notch corresponding to the position of the second linear drive device; and a fixed connecting plate is arranged on the rear side of the portal frame, the upper part of the fixed connecting plate is fixedly connected with the second linear driving device, and the lower part of the fixed connecting plate is fixedly connected with the fixed plate.
10. An apparatus for supporting pipetting and washing co-located operation according to claim 1, wherein a guide shaft is vertically fixed in the frame of the gantry, and the guide shaft penetrates through the driving plate, the fixing plate and the push plate from top to bottom in sequence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210969448.9A CN115228527B (en) | 2022-08-12 | 2022-08-12 | Device for supporting pipetting and cleaning co-located operations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210969448.9A CN115228527B (en) | 2022-08-12 | 2022-08-12 | Device for supporting pipetting and cleaning co-located operations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115228527A true CN115228527A (en) | 2022-10-25 |
| CN115228527B CN115228527B (en) | 2023-07-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210969448.9A Active CN115228527B (en) | 2022-08-12 | 2022-08-12 | Device for supporting pipetting and cleaning co-located operations |
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| Country | Link |
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| CN (1) | CN115228527B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2821284A1 (en) * | 2001-02-23 | 2002-08-30 | Univ Pasteur | APPARATUS FOR THE COLLECTION AND DEPOSITION OF MICRO-SOLUTIONS |
| CN110433886A (en) * | 2019-09-05 | 2019-11-12 | 东莞市聚瑞电气技术有限公司 | New construction accurate pipettor, liquid shifting equipment and liquid relief method |
| CN111266358A (en) * | 2020-03-30 | 2020-06-12 | 北京美联泰科生物技术有限公司 | Cleaning device |
-
2022
- 2022-08-12 CN CN202210969448.9A patent/CN115228527B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2821284A1 (en) * | 2001-02-23 | 2002-08-30 | Univ Pasteur | APPARATUS FOR THE COLLECTION AND DEPOSITION OF MICRO-SOLUTIONS |
| CN110433886A (en) * | 2019-09-05 | 2019-11-12 | 东莞市聚瑞电气技术有限公司 | New construction accurate pipettor, liquid shifting equipment and liquid relief method |
| CN111266358A (en) * | 2020-03-30 | 2020-06-12 | 北京美联泰科生物技术有限公司 | Cleaning device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115228527B (en) | 2023-07-21 |
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