CN115220622A - Chromosome image editing method, analysis device, and storage medium - Google Patents
Chromosome image editing method, analysis device, and storage medium Download PDFInfo
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Abstract
The application provides a chromosome image editing method, an analysis device and a storage medium, wherein the method comprises the following steps: displaying a chromosome marker map, wherein the chromosome marker map comprises a plurality of chromosomes; acquiring a triggered editing mode, and acquiring editing operation on a target chromosome in a chromosome marker map; and editing the target chromosome according to the editing operation in the editing mode. The present application aims to improve the flexibility of editing chromosome marker maps.
Description
Technical Field
The present application relates to the field of chromosome analysis technologies, and in particular, to a chromosome image editing method, a chromosome image analyzing apparatus, and a storage medium.
Background
The chromosome analysis technology takes metaphase chromosomes as research objects, and analyzes, compares, sorts and numbers the chromosomes by means of a banding technique according to the characteristics of the length of the chromosomes, the positions of centromeres, the proportion of long and short arms, the existence of satellites and the like. Chromosome analysis requires a physician to observe the chromosome structure and the number of variations in the chromosome image for diagnosis.
Due to the flexibility of the chromosome and the discreteness of the sample, various overlapping and adhesion phenomena often exist in the chromosome image, and the accuracy of chromosome analysis is influenced. Therefore, the current chromosome analysis system can mark a plurality of chromosomes in the chromosome image to obtain a chromosome mark map, thereby better assisting a doctor in chromosome analysis. However, in the prior art, only chromosomes in the chromosome group map can be adjusted, the chromosome marker map cannot be edited, the editing flexibility is low, and the chromosome analysis effect and experience degree are greatly influenced.
Disclosure of Invention
The present application is directed to a chromosome image editing method, a chromosome image analyzing apparatus, and a storage medium, and aims to improve the editing flexibility of a chromosome marker map, thereby improving the chromosome analysis effect and experience.
In a first aspect, the present application provides a chromosome image editing method, including:
displaying a chromosome marker map, wherein the chromosome marker map comprises a plurality of chromosomes;
acquiring a triggered editing mode, and acquiring editing operation on a target chromosome in the chromosome marker map;
and editing the target chromosome in the editing mode according to the editing operation.
In a second aspect, the present application also provides a chromosome image analysis device comprising a display screen, a processor, a memory, and a computer program stored on the memory and executable by the processor, wherein the computer program, when executed by the processor, implements the steps of the chromosome image editing method as described above.
In a third aspect, the present application further provides a computer-readable storage medium having a computer program stored thereon, where the computer program, when executed by a processor, implements the steps of the chromosome image editing method as described above.
The application provides a chromosome image editing method, an analysis device and a storage medium, and displays a chromosome marker map, wherein the chromosome marker map comprises a plurality of chromosomes; acquiring a triggered editing mode, and acquiring editing operation on a target chromosome in the chromosome marker map; and editing the target chromosome according to the editing operation in the editing mode. The user can flexibly trigger various editing modes through the displayed chromosome marker map, so that the target chromosome can be edited according to editing operation in different editing modes, the editing flexibility of the chromosome marker map is greatly improved, and the chromosome analysis effect and the user experience degree are favorably improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 is a schematic flowchart of a chromosome image editing method according to an embodiment of the present application;
FIG. 2 is a schematic diagram of a chromosome marker map provided in accordance with the present embodiment;
FIG. 3 is a schematic diagram of a result display interface according to the present embodiment;
FIG. 4 is another schematic diagram of a result display interface provided in accordance with an embodiment of the present invention;
FIG. 5 is another schematic diagram of a result display interface provided in accordance with an embodiment of the present invention;
FIG. 6 is another schematic diagram of a result display interface provided in accordance with an embodiment of the present invention;
FIG. 7 is another schematic diagram of a result display interface provided in accordance with an embodiment of the present invention;
FIG. 8 is another schematic diagram of a result display interface provided in accordance with an embodiment of the present invention;
fig. 9 is a block diagram schematically illustrating a structure of a chromosome image analysis apparatus according to an embodiment of the present application.
The implementation, functional features and advantages of the objectives of the present application will be further explained with reference to the accompanying drawings.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some, but not all, of the embodiments of the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The flowcharts shown in the figures are illustrative only and do not necessarily include all of the contents and operations/steps, nor do they necessarily have to be performed in the order described. For example, some operations/steps may be decomposed, combined or partially combined, so that the actual execution sequence may be changed according to the actual situation.
The embodiment of the application provides a chromosome image editing method, analysis equipment and a storage medium. The chromosome image editing method can be applied to chromosome image analysis equipment, the chromosome image analysis equipment is terminal equipment for example, and the terminal equipment can be electronic equipment such as a mobile phone, a tablet computer, a notebook computer, a desktop computer and an intelligent television.
Some embodiments of the present application will be described in detail below with reference to the accompanying drawings. The embodiments and features of the embodiments described below can be combined with each other without conflict.
Referring to fig. 1, fig. 1 is a schematic flowchart illustrating a method for editing a chromosome image according to an embodiment of the present disclosure.
As shown in fig. 1, the chromosome image editing method includes steps S101 to S103.
Step S101, displaying a chromosome marker map, wherein the chromosome marker map comprises a plurality of chromosomes.
Wherein the plurality of chromosomes in the chromosome marker map comprise preset markers, and the preset markers comprise at least one of color markers, contour markers and character markers. The color mark comprises color rendering on the chromosome body or around the chromosome, the outline mark comprises an outline line segment added on the chromosome edge, and the character mark comprises at least one mark of characters, symbols, letters and patterns. Note that the color mark, the outline mark, and the character mark can be freely set by the user in combination. For example, the default marker is a red outline marker or a green outline marker.
Wherein the plurality of chromosomes comprises 1 to 23 chromosomes. For example, the number of somatic chromosomes in a human body is 23 pairs, of which 22 pairs are common to both men and women and are called autosomes, and the other pair is sex-determining chromosomes, which are different between men and women and are called sex chromosomes, while between men and women are XY and between women are XX.
The chromosome image includes a plurality of chromosomes, the plurality of chromosomes in the chromosome image are labeled to obtain a chromosome marker map, and the plurality of chromosomes in the chromosome marker map are analyzed and observed, so that a doctor can diagnose according to the variation of the structures and the numbers of the plurality of chromosomes, and the chromosome analysis is better assisted by the doctor. According to the embodiment of the application, the target chromosome in the chromosome marker map can be edited by determining the corresponding editing mode flexibly and effectively according to the editing operation of the user, and the improvement of the flexibility of chromosome editing is facilitated.
In one embodiment, the chromosomes in the chromosome marker map display outline markers. Contour markers are added at the edges of the chromosome according to the target recognition result of the chromosome; the target recognition result comprises a first type of chromosome and a second type of chromosome, the first type of chromosome comprises chromosomes with targets recognized as normal, and the second type of chromosome comprises chromosomes with targets recognized as abnormal; the contour markers include a first contour marker added to a first chromosome-like edge and a second contour marker added to a second chromosome-like edge. It should be noted that, through the first contour mark and the second contour mark, a doctor can clearly identify the normal chromosome and the abnormal chromosome in the chromosome mark map, so that the efficiency and the accuracy of distinguishing the chromosome are improved, and the situations of misdiagnosis and missed diagnosis are avoided.
Illustratively, the first labeling process for the first chromosome type in the chromosome image includes adding a red contour mark around the first chromosome type, and the second labeling process for the second chromosome type in the chromosome image includes adding a green contour mark around the second chromosome type, and the chromosome image composed of the first chromosome type to which the red contour mark is added and the second chromosome type to which the green contour mark is added is used as the chromosome mark map.
Illustratively, as shown in fig. 2, a chromosome marker map 210 is displayed on a display screen of the chromosome image analysis apparatus, and the chromosome marker map 210 includes a first type chromosome 211 subjected to a first marking process and a second type chromosome 212 subjected to a second marking process. Wherein the first chromosome 211 is added with a red contour mark, the second chromosome 212 is added with a green contour mark, the chromosome mark map 210 can also comprise a third chromosome 213 which is not identified by target identification, and the third chromosome 213 can be not added with a mark.
In one embodiment, a chromosome image to be analyzed is acquired; carrying out target identification on the chromosome image to obtain a target identification result, wherein the target identification result comprises a first type chromosome and a second type chromosome, the first type chromosome comprises a chromosome with a normal target identification, and the second type chromosome comprises a chromosome with an abnormal target identification; and adding a first contour mark to the edge of the first chromosome in the chromosome image, adding a second contour mark to the edge of the second chromosome in the chromosome image to obtain a chromosome mark image, and displaying the chromosome mark image.
It should be noted that the second type of chromosome includes chromosomes whose target is recognized as abnormal, however, the target recognition result is not necessarily completely accurate, and the second type of chromosome obtained by target recognition is highly likely to be abnormal. The second contour mark is carried out on the second chromosome, so that the doctor can pay attention to the second chromosome with the second contour mark, the effect of assisting the doctor in identifying the normal chromosome and the abnormal chromosome is achieved, and the efficiency and the accuracy of distinguishing the chromosomes are improved.
In one embodiment, the chromosome marker map is displayed on a result display interface; the result display interface comprises a first display area and a second display area, the first display area is used for displaying the chromosome marker map, the second display area is used for displaying the editing icons, and the editing icons comprise contour connection icons, contour expansion icons, contour deletion icons, contour creation icons, cross segmentation icons and/or segmentation overlapping icons.
It should be noted that after the chromosome image analysis device generates the chromosome marker map, the chromosome marker map may be displayed in the result display interface, so that a doctor can clearly identify the normal chromosome and the abnormal chromosome in the chromosome marker map, and can trigger different editing modes based on different editing icons, thereby completing editing of the target chromosome in the chromosome marker map, and improving the editing flexibility.
Illustratively, as shown in fig. 3, the result presentation interface 200 includes a first presentation area 21 and a second presentation area 22, the first presentation area 21 is used for displaying the chromosome marker map 210, the second presentation area 22 is used for displaying the editing icon, and the editing icon shown in fig. 3 includes a contour connection icon, a contour extension icon, a contour deletion icon, a contour creation icon, a cross division icon, and a division overlap icon, and a doctor can start a corresponding editing mode by triggering the editing icon, so that the doctor can edit the target chromosome in the chromosome marker map in the editing mode corresponding to the editing icon.
In one embodiment, the results display interface includes a third display region for displaying the karyotype chart. The karyotype chart is an image in which all chromosomes in one cell are arranged in order of their size and shape characteristics. And (3) performing karyotype analysis on the first type of chromosomes in the chromosome image, and comparing, sequencing and numbering a plurality of first type of chromosomes according to characteristic information such as the length, the position of the centromere, the proportion of long and short arms, the existence of satellite and the like of the first type of chromosomes to obtain a chromosome set diagram. Optionally, the area of the first display area is larger than that of the third display area, and the chromosome marking map and the chromosome karyotype map are displayed in the result display interface at the same time, so that a doctor can observe a chromosome marking result and a chromosome analysis result better, and the accuracy of chromosome identification is improved.
Illustratively, as shown in fig. 4, the result display interface 200 further includes a third display region 23, the third display region 23 is used for displaying the karyotype map 230, and the chromosome marker map 210 can be more clearly displayed through fig. 4. Optionally, the target identification result further includes a count value of the first type chromosome in the chromosome marker map 210; the third display area is also used to display the count value.
In an embodiment, the target recognition result further comprises a count value of the first type of chromosome. Generally, the number of chromosomes in chromosome cells of different organisms is fixed, so it is important to count the number of first type chromosomes in a chromosome image. Illustratively, as shown in fig. 4, the target recognition result includes 37 chromosomes of the first type, so the count (value) of the chromosomes of the first type is 37, and the third display region is further used for displaying the number of contours, which is the number of chromosomes of the first type including the first contour marker, so if the first contour marker is performed on all of the 37 chromosomes of the first type, the number of contours is also 37.
In an embodiment, the result presentation interface may include a plurality of regions, buttons, and controls having other functions, where the plurality of regions, buttons, and controls each have a corresponding function, and the positions, arrangements, and functions of the plurality of regions, buttons, and controls may be flexibly set.
Illustratively, the result presentation interface further comprises an undo icon, a resume icon, and a save icon. The canceling icon is used for canceling the operation of the user on the chromosome marker map or the chromosome karyotype map, the restoring icon is used for saving the operation of the user on the chromosome marker map or the chromosome karyotype map before the user operates the chromosome marker map or the chromosome karyotype map, and the saving icon is used for saving the operation of the user on the chromosome marker map or the chromosome karyotype map. It can be understood that the result presentation interface further includes other icons, buttons, or controls, which are not listed in this embodiment.
In one embodiment, after displaying the karyotype chart in the results display interface, the method further includes: and if the preset operation of the user in the third display area is detected, switching and displaying the chromosome genotype map in the third display area and the chromosome marker map in the first display area. The preset operation of the user in the third display area comprises controlling a cursor to click in the third display area, so that the chromosome group type graph in the third display area is transferred to the first display area to be displayed, and the chromosome mark graph in the first display area is transferred to the third display area to be displayed, so that the chromosome group type graph can be observed better, and the chromosome group type graph can be operated.
Correspondingly, after the chromosome polymorphism map and the chromosome marker map are switched and displayed, if the preset operation of the user in the third display area is detected, the chromosome marker map in the third display area and the chromosome polymorphism map in the first display area are switched and displayed, so that the chromosome marker map can be observed better, and the first type of chromosomes or the second type of chromosomes in the chromosome marker map can be operated.
And step S102, acquiring the triggered editing mode, and acquiring the editing operation on the target chromosome in the chromosome marker map.
After the chromosome marker map is displayed, the user can edit the target chromosome in the displayed chromosome marker map, so that the edited target chromosome achieves the effect desired by the user. The editing operation comprises a single-click operation, a double-click operation, a sliding operation or a long-press operation and the like.
In one embodiment, the editing operation corresponds to an editing mode; under the same editing mode, different editing operations can be carried out on the target chromosome; alternatively, the same editing operation may edit the target chromosome differently in different editing modes.
It is noted that the target chromosome may include a contour marker; the editing operation of the user on the target chromosome in the chromosome marker map may also be the editing operation of the user on the contour marker of the target chromosome in the chromosome marker map, which is not specifically limited in this embodiment.
The editing operation corresponds to an editing mode, and the editing mode may be determined by a user before the editing operation is performed or determined by the user after the editing operation is performed. The target chromosome is edited according to the editing operation in the editing mode, the chromosome marker map can be accurately and effectively edited, and the editing flexibility is high.
In some embodiments, the user first triggers an editing mode in which the target chromosome can be edited; the user then triggers an editing operation on the target chromosome in the chromosome marking map, so that the triggered editing mode can be acquired. In other embodiments, the user first triggers an editing operation on a target chromosome in the chromosome marker map; the user then triggers the editing mode, which is determined by the user after the editing operation is performed and which corresponds to the editing operation previously performed by the user.
In one embodiment, obtaining the triggered edit mode includes: and displaying an editing icon, and determining a triggered editing mode according to the editing icon triggered by the user. The triggered editing mode is determined according to the editing icon triggered by the user, and different editing icons correspond to different editing modes. Optionally, the number of the editing icons is multiple, each editing icon has a corresponding editing mode, and the editing mode corresponding to the editing icon is determined as the triggered editing mode.
For example, the edit icon includes a contour connection icon, the contour connection icon corresponding to a contour connection mode; when the user starts the contour connection mode by triggering the contour connection icon, if the user performs an editing operation on the target chromosome in the chromosome marker map, the editing operation corresponds to the contour connection mode.
In one embodiment, obtaining the triggered edit mode includes: and determining the triggered editing mode according to the menu items in the menu bar triggered by the user, wherein different menu items correspond to different editing modes. Optionally, there are a plurality of menu items, and the specific settings of the plurality of menu items in the menu bar may be determined according to actual situations.
In one embodiment, obtaining the triggered edit mode includes: acquiring a mapping relation table between preset editing operation and an editing mode; and determining a triggered editing mode from the mapping relation table according to the editing operation of the user on the target chromosome in the chromosome marking map. The mapping relation table can be flexibly set according to actual conditions.
In one embodiment, the chromosome marker map includes outline markers displayed outside the chromosome, and the editing icons include outline editing icons for triggering an outline editing mode in which the outline markers of the chromosome can be edited. The outline editing icon can be displayed on the result display interface, and the position, size, shape and the like of the outline editing icon can be flexibly set.
Illustratively, as shown in FIG. 5, the outline edit icon may be displayed in the second presentation area 22 of the results presentation interface 200. Wherein the outline editing icons in the second presentation area 22 include an outline connection icon, an outline extension icon, an outline deletion icon, and an outline creation icon.
And step S103, editing the target chromosome according to the editing operation in the editing mode.
In one embodiment, the contour edit icon includes at least one of a contour connection icon and a contour extension icon; the outline connection icon is used for triggering an outline connection mode, and at least two outline marks can be connected in the outline connection mode; the outline expansion icon is used for triggering an outline expansion mode, and the outline marker can be expanded in the outline expansion mode.
It should be noted that, after the at least two contour marks are connected, the at least two contour marks corresponding to the connection operation can be merged into one; after the extension operation is performed on the outline marker, the outline line segment of the outline marker corresponding to the extension operation can be extended. Through the contour connection icon and the contour expansion icon, the chromosome marker map can be flexibly edited, and the editability of the chromosome marker map is improved, so that a doctor can clearly identify normal chromosomes and abnormal chromosomes in the chromosome marker map.
In one embodiment, the triggered edit mode is a profile join mode; editing the target chromosome according to the editing operation in an editing mode, wherein the editing mode comprises the following steps: in the contour connection mode, contour markers of two chromosomes are merged based on a user's selection operation on the two chromosomes in the chromosome marker map. The doctor can manually edit the chromosome marker map, correct the errors of the contour markers in the chromosome marker map, and improve the efficiency and accuracy of distinguishing the chromosome, thereby avoiding the occurrence of misdiagnosis and missed diagnosis.
Illustratively, as shown in fig. 6, the result presentation interface 200 displays a chromosome marker map 210 and a contour connection icon 221, and the user controls the chromosome marker map 210 to enter a contour connection mode by triggering the contour connection icon 221; based on the user's selection operation of the first target chromosome 211 and the second target chromosome 212, in the contour connecting mode, the contour marker of the first target chromosome 211 and the contour marker of the second target chromosome 212 are merged into a target contour marker.
In an embodiment, the triggered editing mode is a contour extension mode, and in the editing mode, the target chromosome is edited according to an editing operation, including: in the contour extension mode, the contour marker of the target chromosome is extended based on the user's selection of the outer edge region of the contour marker of the target chromosome. The contour expansion is to select a target chromosome, smear around a contour marker of the target chromosome with a certain radius by taking a track point as a circle center according to a mouse motion track, and combine the smeared position with the existing contour marker to obtain a new contour marker.
In the contour extension mode, a doctor can manually perform contour extension on the chromosome marker map, reinforce the contour marker in the chromosome marker map, and improve the efficiency and accuracy of chromosome discrimination, thereby avoiding misdiagnosis and missed diagnosis. Optionally, the smearing operation of the contour marker of the target chromosome by the user may be performed on other pop-up windows or interfaces, which is not specifically limited in this embodiment.
Illustratively, as shown in fig. 6, the result presentation interface 200 displays a chromosome tag map 210 and a contour extension icon 222, and the user controls the chromosome tag map 210 to enter a contour extension mode by triggering the contour connection icon 222; in the contour extension mode, based on a user selection operation on the first target chromosome 211, the first target chromosome 211 can be displayed within a preset popup window, and the user can be enabled to extend the contour marker of the first target chromosome 211 within the preset popup window.
In an embodiment, the outline editing icon includes at least one of an outline delete icon and an outline create icon; the outline deleting icon is used for triggering an outline deleting mode, and the outline mark can be deleted in the outline deleting mode; the outline creation icon is used to trigger an outline creation mode in which outline markers can be created. It should be noted that the contour markers of the chromosomes in the chromosome marker map can be manually deleted and created by a doctor. The outline editing icon and the outline creating icon can flexibly increase and decrease the outline marks of the chromosome mark map. The method has the advantages that a doctor can manually edit the chromosome marker map, correct the misidentification and the misidentification of the contour marker in the chromosome marker map, improve the efficiency and the accuracy of distinguishing the chromosome, and avoid misdiagnosis and missed diagnosis.
In one embodiment, the triggered editing mode is a profile deletion mode; editing the target chromosome according to the editing operation in an editing mode, wherein the editing mode comprises the following steps: in the contour deletion mode, the contour marker of the target chromosome is deleted based on a user's selection operation of the contour marker of the target chromosome.
Illustratively, as shown in fig. 7, the result presentation interface 200 displays a chromosome marker map 210 and a contour deletion icon 223, and the user controls the chromosome marker map 210 to enter a contour deletion mode by triggering the contour deletion icon 223; in the contour deletion mode, the contour marker of the target chromosome 213 can be deleted based on the user's selection operation of the target chromosome 213.
In one embodiment, the triggered edit mode is a profile creation mode; editing the target chromosome according to the editing operation in an editing mode, wherein the editing mode comprises the following steps: in the contour creation mode, a contour marker of the target chromosome is created based on a user's smearing operation on the contour marker of the target chromosome.
Illustratively, as shown in fig. 7, the result presentation interface 200 displays a chromosome marker map 210 and a contour creation icon 224, and the user controls the chromosome marker map 210 to enter a contour creation mode by triggering the contour creation icon 224; in the contour creation mode, a contour marker of the target chromosome 214 is created based on a user's selection operation on the target chromosome 214, where the target chromosome 214 may be a third chromosome, that is, a chromosome that is not recognized by the target recognition, and the target chromosome 214 may also be a chromosome that has undergone a contour marker deletion operation.
In one embodiment, the edit icon includes a cross-split icon and/or a split overlap icon; the cross segmentation icon is used for triggering a cross segmentation mode, for example, triggering a target chromosome in a cross shape in the chromosome marker map to enter the cross segmentation mode, and the target chromosome in the cross shape can be segmented in the cross segmentation mode; the split overlap icon is used to trigger a split overlap mode, for example, to trigger the target chromosomes in the chromosome marker map in an overlapped state to enter the split overlap mode, in which the target chromosomes in the overlapped state can be split.
The cross division is completed by performing characteristic recognition according to a characteristic image of a cross chromosome, and the division and the superposition are completed by performing characteristic recognition according to a superposed image of two chromosomes. The chromosomes in the chromosome marker map in the cross shape can be flexibly edited by the cross division icon, and the chromosomes in the chromosome marker map in the overlapped state can be flexibly edited by the division overlapping icon, so that the editability of the chromosomes in the chromosome marker map is improved, and a doctor can manually divide the chromosomes in the cross shape and the chromosomes in the overlapped state.
In one embodiment, the triggered editing mode comprises a cross segmentation mode; editing the target chromosome according to the editing operation in an editing mode, wherein the editing mode comprises the following steps: in the cross division mode, the target chromosome in the cross shape is divided based on a selection operation of the user on the target chromosome in the cross shape. In the cross segmentation mode, the doctor can manually segment the cross-shaped target chromosomes in the chromosome marker map, so as to separate the cross-shaped target chromosomes, improve the accuracy of chromosome identification, and avoid misdiagnosis and missed diagnosis.
Illustratively, as shown in fig. 8, the result presentation interface 200 displays a chromosome marker map 210 and a cross segmentation icon 225, and the user controls the chromosome marker map 210 to enter a cross segmentation mode by triggering the cross segmentation icon 225; in the cross division mode, the contour marker of the target chromosome 215 having a cross shape can be divided based on a user selection operation on the target chromosome 214, so that two chromosomes separated from each other can be obtained.
In one embodiment, the triggered edit mode includes a split overlap mode; editing the target chromosome according to the editing operation in an editing mode, wherein the editing mode comprises the following steps: in the split overlap mode, the target chromosomes in the overlapped state are split based on a user's selection operation on the target chromosomes in the overlapped state. In the split-overlap mode, the doctor can manually split the target chromosomes in the overlapped state in the chromosome marker map, so as to separate the target chromosomes in the overlapped state, improve the accuracy of chromosome identification, and avoid misdiagnosis and missed diagnosis.
Illustratively, as shown in fig. 8, the result presentation interface 200 displays a chromosome marker map 210 and a cross segmentation icon 225, and the user controls the chromosome marker map 210 to enter a cross segmentation mode by triggering the cross segmentation icon 225; in the cross division mode, the contour markers of the cross-shaped target chromosome 215 can be divided based on the user's selection operation on the target chromosome 214, so that two chromosomes separated from each other are obtained.
In one embodiment, the triggered editing modes include a cross segmentation mode and a segmentation overlap mode; editing the target chromosome according to the editing operation in an editing mode, wherein the editing mode comprises the following steps: in the cross segmentation mode, segmenting the cross-shaped target chromosome based on the selection operation of a user on the cross-shaped target chromosome; and in the segmentation and overlapping mode, segmenting the target chromosome in the overlapping state based on the selection operation of the target chromosome in the overlapping state by the user. The chromosome marker map can be flexibly edited, and the editability of the chromosome marker map is improved, so that doctors can clearly identify normal chromosomes and abnormal chromosomes in the chromosome marker map, and the accuracy of chromosome identification is improved.
In an embodiment, the edit icon further includes a merge icon for triggering at least two chromosomes in the chromosome marker map to enter a merge mode in which the two chromosomes in the chromosome marker map can be merged. In the merge mode, the doctor can manually splice two chromosomes which are split in the chromosome marker map, so that the two chromosomes in the split state are merged, and the accuracy of chromosome identification is improved.
Illustratively, the triggered edit mode includes a merge mode; editing the target chromosome according to the editing operation in an editing mode, wherein the editing mode comprises the following steps: and splicing the first chromosome and the second chromosome corresponding to the selection operation based on the selection operation of the user on the first chromosome and the second chromosome in the merging mode, wherein the splicing point is a centromere, for example, and the merged chromosome is obtained.
In the method for editing a chromosome image provided in the above embodiment, the chromosome marker map is displayed, wherein the chromosome marker map includes a plurality of chromosomes; acquiring the editing operation of a user on a target chromosome in a chromosome marker map; and acquiring a triggered editing mode, and editing the target chromosome according to editing operation in the editing mode. The user can flexibly trigger various editing modes through the displayed chromosome marker map, so that the target chromosome can be edited according to editing operation in different editing modes, the editing flexibility of the chromosome marker map is greatly improved, and the chromosome analysis effect and the user experience degree are favorably improved.
Referring to fig. 9, fig. 9 is a schematic block diagram illustrating a structure of a chromosome image analysis device according to an embodiment of the present application, where the chromosome image analysis device includes a terminal device.
As shown in fig. 9, the chromosome image analysis device 300 includes a display screen 301, a processor 302, and a memory 303 connected by a system bus 304, wherein the memory 303 may include a nonvolatile storage medium and an internal memory.
The non-volatile storage medium may store a computer program. The computer program includes program instructions that, when executed, cause the processor 302 to perform any of the chromosome image editing methods.
The processor 302 is used to provide computing and control capabilities to support the operation of the entire chromosome image analysis device 300.
The internal memory provides an environment for running a computer program in the non-volatile storage medium, which, when executed by the processor 302, causes the processor 302 to perform any one of the chromosome image editing methods.
The chromosome image analysis device 300 may further include a communication interface for performing communication such as transmission of assigned tasks and the like. It will be understood by those skilled in the art that the structure shown in fig. 9 is a block diagram of only a part of the structure related to the present embodiment, and does not constitute a limitation of the chromosome image analysis apparatus to which the present embodiment is applied, and a specific chromosome image analysis apparatus may include more or less components than those shown in the figure, or combine some components, or have a different arrangement of components.
It should be understood that the Processor 302 may be a Central Processing Unit (CPU), and that the Processor 302 may also be other general purpose processors, digital Signal Processors (DSPs), application Specific Integrated Circuits (ASICs), field Programmable Gate Arrays (FPGAs) or other Programmable logic devices, discrete Gate or transistor logic devices, discrete hardware components, etc. Wherein the general purpose processor may be a microprocessor, or the processor 302 may be any conventional processor, etc.
Wherein, in one embodiment, the processor 302 is configured to run a computer program stored in the memory 303 to implement the steps of:
displaying a chromosome marker map, wherein the chromosome marker map comprises a plurality of chromosomes;
acquiring a triggered editing mode, and acquiring editing operation on a target chromosome in the chromosome marker map;
and editing the target chromosome according to the editing operation in the editing mode.
In one embodiment, the processor 302, when implementing the get triggered edit mode, is configured to implement:
and displaying an editing icon, and determining a triggered editing mode according to the editing icon triggered by the user.
In one embodiment, the chromosomal marker map comprises a silhouette marker displayed outside the chromosome, and the editing icon comprises a silhouette editing icon for triggering a silhouette editing mode in which the silhouette marker is editable.
In one embodiment, the outline editing icon comprises at least one of an outline connection icon and an outline expansion icon;
the contour connection icon is used for triggering a contour connection mode, and at least two contour marks can be connected in the contour connection mode;
the outline expansion icon is used for triggering an outline expansion mode, and the outline marker can be expanded in the outline expansion mode.
In one embodiment, the triggered edit mode is a contour connection mode; when the processor 302 is configured to implement the editing of the target chromosome according to the editing operation in the editing mode, it is configured to implement:
and in the contour connection mode, merging contour markers of two chromosomes based on the selection operation of a user on the two chromosomes in the chromosome marker map.
In one embodiment, the triggered editing mode is a contour extension mode; when the processor 302 is configured to implement the editing of the target chromosome according to the editing operation in the editing mode, it is configured to implement:
and in the contour extension mode, extending the contour marker of the target chromosome based on the selection of the outer edge region of the contour marker of the target chromosome by a user.
In one embodiment, the outline editing icon comprises at least one of an outline delete icon and an outline create icon;
the outline deleting icon is used for triggering an outline deleting mode, and the outline mark can be deleted in the outline deleting mode;
the outline creation icon is used to trigger an outline creation mode in which the outline marker can be created.
In one embodiment, the contour marker is added at the edge of the chromosome according to the target recognition result of the chromosome;
the target recognition result comprises a first type of chromosome and a second type of chromosome, the first type of chromosome comprises chromosomes with targets recognized as normal, the second type of chromosome comprises chromosomes with targets recognized as abnormal, the contour markers comprise a first contour marker and a second contour marker, the first contour marker is added to the first type of chromosome edge, and the second contour marker is added to the second type of chromosome edge.
In one embodiment, the edit icon comprises a cross-split icon and/or a split overlap icon;
the cross segmentation icon is used for triggering a cross segmentation mode, and the target chromosome in a cross shape can be segmented in the cross segmentation mode;
the segmentation overlap icon is used for triggering a segmentation overlap mode in which the target chromosome in an overlapped state can be segmented.
In one embodiment, the triggered editing mode comprises a cross segmentation mode and/or a segmentation overlap mode; when the processor 302 is configured to implement the editing of the target chromosome according to the editing operation in the editing mode, it is configured to implement:
in the cross segmentation mode, segmenting a cross-shaped target chromosome based on a selection operation of a user on the cross-shaped target chromosome; and/or
In the segmentation overlapping mode, the target chromosomes in the overlapping state are segmented based on the selection operation of the target chromosomes in the overlapping state by the user.
The chromosome marker map is displayed on a result display interface;
the result display interface comprises a first display area and a second display area, the first display area is used for displaying the chromosome marker map, the second display area is used for displaying the editing icons, and the editing icons comprise contour connection icons, contour expansion icons, contour deletion icons, contour creation icons, cross segmentation icons and/or segmentation overlapping icons.
It should be clearly understood by those skilled in the art that, for convenience and brevity of description, the specific working process of the chromosome image analysis apparatus described above may refer to the corresponding process in the foregoing embodiment of the chromosome image editing method, and details are not described herein again.
The application is operational with numerous general purpose or special purpose computing system environments or configurations. For example: personal computers, server computers, hand-held or portable devices, tablet-type devices, multiprocessor systems, microprocessor-based systems, set top boxes, programmable consumer electronics, network PCs, minicomputers, mainframe computers, distributed computing environments that include any of the above systems or devices, and the like.
Embodiments of the present application also provide a computer-readable storage medium, where a computer program is stored on the computer-readable storage medium, where the computer program includes program instructions, and when the program instructions are executed, the method that is implemented may refer to the embodiments of the chromosome image editing method of the present application.
The computer-readable storage medium may be an internal storage unit of the chromosome image analysis device according to the foregoing embodiment, for example, a hard disk or a memory of the chromosome image analysis device. The computer-readable storage medium may also be an external storage device of the chromosome image analysis device, such as a plug-in hard disk, a Smart Media Card (SMC), a Secure Digital (SD) Card, a Flash memory Card (Flash Card), or the like provided on the chromosome image analysis device.
It is to be understood that the terminology used in the description of the present application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this specification and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should also be understood that the term "and/or" as used in this specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items and includes such combinations. It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or system that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or system. Without further limitation, an element defined by the phrases "comprising one of 8230; \8230;" 8230; "does not exclude the presence of additional like elements in a process, method, article, or system that comprises the element.
The above-mentioned serial numbers of the embodiments of the present application are merely for description and do not represent the merits of the embodiments. While the invention has been described with reference to specific embodiments, the scope of the invention is not limited thereto, and those skilled in the art can easily conceive various equivalent modifications or substitutions within the technical scope of the invention. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (13)
1. A chromosome image editing method, comprising:
displaying a chromosome marker map, wherein the chromosome marker map comprises a plurality of chromosomes;
acquiring a triggered editing mode, and acquiring editing operation on a target chromosome in the chromosome marker map;
and editing the target chromosome in the editing mode according to the editing operation.
2. The chromosome image editing method according to claim 1, wherein the acquiring the triggered editing mode includes:
and displaying an editing icon, and determining a triggered editing mode according to the editing icon triggered by the user.
3. The chromosomal image editing method according to claim 2, wherein the chromosomal marker map includes a contour marker displayed outside the chromosome, and the editing icon includes a contour editing icon for triggering a contour editing mode in which the contour marker can be edited.
4. The chromosome image editing method according to claim 3, wherein the contour editing icon includes at least one of a contour connection icon and a contour extension icon;
the contour connection icon is used for triggering a contour connection mode, and at least two contour marks can be connected in the contour connection mode;
the outline expansion icon is used for triggering an outline expansion mode, and the outline marker can be expanded in the outline expansion mode.
5. The chromosome image editing method according to claim 4, wherein the triggered editing mode is a contour connection mode; the editing the target chromosome according to the editing operation in the editing mode comprises:
and in the contour connection mode, merging contour markers of two chromosomes based on the selection operation of a user on the two chromosomes in the chromosome marker map.
6. The chromosome image editing method according to claim 4, wherein the triggered editing mode is a contour expansion mode; the editing the target chromosome according to the editing operation in the editing mode comprises:
and in the contour extension mode, extending the contour marker of the target chromosome based on the selection of the outer edge region of the contour marker of the target chromosome by a user.
7. The chromosome image editing method according to claim 3, wherein the contour editing icon includes at least one of a contour deletion icon and a contour creation icon;
the outline deleting icon is used for triggering an outline deleting mode, and the outline mark can be deleted in the outline deleting mode;
the outline creation icon is used to trigger an outline creation mode in which the outline marker can be created.
8. The chromosome image editing method according to claim 3, wherein the contour marker is added at an edge of the chromosome based on a result of the object recognition on the chromosome;
the target identification result comprises a first type chromosome and a second type chromosome, the first type chromosome comprises chromosomes with targets identified as normal, the second type chromosome comprises chromosomes with targets identified as abnormal, the contour mark comprises a first contour mark and a second contour mark, the first contour mark is added to the first type chromosome edge, and the second contour mark is added to the second type chromosome edge.
9. The chromosome image editing method according to any one of claims 2 to 8, wherein the editing icon includes a cross-segmentation icon and/or a segmentation-overlap icon;
the cross segmentation icon is used for triggering a cross segmentation mode, and the target chromosome in a cross shape can be segmented in the cross segmentation mode;
the segmentation overlap icon is used for triggering a segmentation overlap mode in which the target chromosome in an overlapped state can be segmented.
10. The chromosome image editing method according to claim 9, wherein the editing the target chromosome according to the editing operation in the editing mode includes:
in the cross segmentation mode, segmenting a cross-shaped target chromosome based on a selection operation of a user on the cross-shaped target chromosome; and/or
In the segmentation overlapping mode, the target chromosomes in the overlapping state are segmented based on the selection operation of the target chromosomes in the overlapping state by the user.
11. The method for editing a chromosome image according to any one of claims 2 to 8, wherein the chromosome marker map is displayed on a result display interface;
the result display interface comprises a first display area and a second display area, the first display area is used for displaying the chromosome marker map, the second display area is used for displaying the editing icons, and the editing icons comprise contour connection icons, contour expansion icons, contour deletion icons, contour creation icons, cross segmentation icons and/or segmentation overlapping icons.
12. A chromosome image analysis device characterized by comprising a display screen, a processor, a memory, and a computer program stored on the memory and executable by the processor, wherein the computer program, when executed by the processor, implements the steps of the chromosome image editing method according to any one of claims 1 to 11.
13. A computer-readable storage medium, having stored thereon a computer program, wherein the computer program, when executed by a processor, implements the steps of the chromosome image editing method according to any one of claims 1 to 11.
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