CN115197813B - Sterile drainage device for bioreactor - Google Patents
Sterile drainage device for bioreactor Download PDFInfo
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- CN115197813B CN115197813B CN202210992079.5A CN202210992079A CN115197813B CN 115197813 B CN115197813 B CN 115197813B CN 202210992079 A CN202210992079 A CN 202210992079A CN 115197813 B CN115197813 B CN 115197813B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/26—Conditioning fluids entering or exiting the reaction vessel
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
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Abstract
The invention discloses a sterile drainage device for a bioreactor, which relates to the technical field of drainage and comprises the following components: the sterilizing rack is a cylinder with a deep groove, and a top cover is arranged at the top of the sterilizing rack; the sealing plate, the sealing plate is circular, the bottom fixed connection of top and top cap of sealing plate, the inside of sterilizing the frame is provided with clamping mechanism, the inside of sterilizing the frame is provided with the reactor, circular slot has been seted up at the top of sterilizing the frame, the inner wall bottom fixedly connected with electricity push rod in circular slot. When the reactor is pushed into the sterilizing frame, the reactor can push the extrusion rod to expand outwards, and the extrusion rod can push the push rod to move in the circular hole through the telescopic lever during expansion.
Description
Technical Field
The invention relates to the technical field of liquid discharge, in particular to a sterile liquid discharge device for a bioreactor.
Background
The bioreactor needs to be sterilized at high temperature and high pressure before experiments are carried out, after the bioreactor is sterilized, the reactor can not completely discharge the liquid in the reactor, and at present, the bioreactor on the market can not clean the liquid in the reactor, so that the sterilization efficiency of the bioreactor is reduced, and therefore, the sterile liquid discharge device for the bioreactor is provided.
Disclosure of Invention
In order to solve the above technical problems, the present invention provides an aseptic drainage device for a bioreactor, comprising:
the sterilizing rack is a cylinder with a deep groove, and a top cover is arranged at the top of the sterilizing rack;
the sealing plate is circular, the top of the sealing plate is fixedly connected with the bottom of the top cover, a clamping mechanism is arranged in the sterilizing frame, a reactor is arranged in the sterilizing frame, a circular groove is formed in the top of the sterilizing frame, and an electric push rod is fixedly connected to the bottom of the inner wall of the circular groove;
the bottom of the inner wall of the sterilizing frame is fixedly connected with a through hole frame, a round hole is formed in the top of the through hole frame, the inner wall of the round hole is fixedly connected with a protection pad, and the bottom of the inner wall of the sterilizing frame is fixedly connected with a high-temperature sterilizer;
the clamping mechanism comprises a circular block, a push rod, a bottom hole, a clamping block, a circular hole, a positioning frame, a semicircular rod, an elastic sheet, an extrusion rod and a telescopic lever, wherein the circular block is fixedly connected with the inner wall of the sterilizing frame, the circular hole is formed in the circular block, the bottom hole is formed in the bottom of the circular block, the positioning frame is fixedly connected with the inner wall of the sterilizing frame, the telescopic lever is rotatably connected with the inner wall of the positioning frame through a bearing, the elastic sheet is fixedly connected with the bottom of the positioning frame through the semicircular rod, a sealing plate is arranged at the bottom of the top cover, the surface of the sealing plate is matched with the inner wall of the sterilizing frame, the sealing plate can enter the sterilizing frame for sealing when the top cover is contracted downwards through an electric push rod, the sealing performance of the high-temperature sterilizer during sterilization is improved, the extrusion rod is fixedly connected with the bottom of the telescopic lever, and the clamping block is fixedly connected with the top of the telescopic lever through the push rod.
Further, the top of the electric push rod is fixedly connected with the bottom of the top cover, the bottom of the top cover is in contact with the top surface of the sterilizing frame, the surface of the sealing plate is in contact with the inner wall of the sterilizing frame, and the bottom surface of the reactor is in contact with the inner ring of the protection pad.
Further, one end of the elastic piece far away from the semicircular rod is fixedly connected with the bottom surface of the telescopic lever, the positioning frame is located below the circular ring block, the push rod is arranged in the circular ring hole, the clamping block is arranged at the inner ring of the circular ring block, and the telescopic lever is obliquely arranged.
Further, the bottom fixedly connected with depression bar of closing plate, the bottom of depression bar is provided with pushing equipment, the inside of reactor is provided with extrusion mechanism, has seted up the bottom opening in the bottom of ring piece, and the top of telescopic lever is in the same place through bottom opening and push rod link together, is provided with four extrusion bars in the bottom of ring piece, presss from both sides tightly fixedly to four faces of reactor through the extrusion bar, increases the stability of reactor when disinfecting, and the extrusion bar can be mutual when contracting through the shell fragment be close to, and the reactor promotes the extrusion bar and expands of being convenient for, the inner wall bottom of reactor is provided with adsorption equipment.
Further, the extrusion mechanism comprises a fixing frame, a storage frame, a circular ring inclined plate, an extrusion pad, an extension hole and a clamping groove, wherein the top of the fixing frame is fixedly connected with the bottom of the compression bar, the storage frame is fixedly connected with the fixing frame through the circular ring inclined plate, four circular arc plates are arranged at the bottom of the fixing frame, the circular arc plates expand to the inner wall of the reactor through the elasticity of an elastic piece, the clamping groove is formed in the lower surface of the fixing frame, and the extrusion pad is fixedly connected with the inner wall of the clamping groove;
the bottom of the fixing frame is provided with an extension hole.
Further, one end of the circular ring inclined plate, which is close to the storage rack, is obliquely downwards arranged, one end of the extrusion pad, which is far away from the clamping groove, is fixedly connected with the surface of the fixing rack, and the storage rack is arranged in the fixing rack.
Further, the adsorption mechanism comprises an arc plate, a triangular block, a connecting plate, a connecting groove, an elastic sheet and cotton fibers, wherein the cotton fibers are fixedly connected with the bottom of the fixing frame, the arc plate is rotationally connected with the bottom of the fixing frame through a rotating shaft, the triangular block is fixedly connected with the bottom surface of the arc plate, the connecting groove is formed in the center of the bottom of the cotton fibers, the end part of the arc plate is hinged with the connecting plate, the fixing frame is fixedly connected with the bottom of the compression bar, a storage frame is arranged above the fixing frame and is convenient for storing liquid in the reactor, the arc plate is fixedly connected with the elastic sheet, and the elastic sheet is fixedly connected with the bottom of the fixing frame;
the triangular blocks are contacted with the bottom of the inner wall of the reactor.
Further, the lower end of the extension hole extends to the inside of the cotton fiber, and the bottom of the extension hole is communicated with the top of the connecting groove.
Further, the liquid pushing mechanism comprises a cross round hole, a cross rod, a circular ring positioning rod, an arc push plate, a chute, an arc pad, an elastic compression rod, a sliding block and a linkage rod, wherein the cross round hole is formed in the lower end of the inner wall of the compression rod, the cross rod is arranged in the cross round hole, the circular ring positioning rod is fixedly connected with the end part of the cross rod, the arc push plate is rotationally connected with the circular ring positioning rod through the elastic compression rod, the arc pad is fixedly connected with the surface of the arc push plate, the chute is formed in the bottom of the arc push plate, and the sliding block is fixedly connected with the top of the fixing frame;
the top of the linkage rod is fixedly connected with the bottom of the cross rod, and the lower surface of the linkage rod is arranged in the extension hole.
Further, the bottom of the linkage rod is hinged with the connecting plate, the cross rod extends to the outer end of the compression bar through the cross round hole, the arc pushing plate is in sliding connection with the sliding block through the sliding groove, and the arc pad is in contact with the inner wall of the reactor.
The invention has the beneficial effects that:
when the reactor is required to be sterilized at high temperature, the high-temperature sterilizer is started, the high-temperature sterilizer performs sterilization treatment on the reactor through the through hole frame, the protection pad is arranged in the round hole to support the bottom of the reactor, when the reactor is pushed into the sterilization frame, the reactor pushes the extrusion rod to expand outwards, the extrusion rod pushes the push rod to move in the circular hole through the telescopic lever during expansion, the clamping block pushes the surface of the reactor through the push rod, the stability of the reactor during sterilization is improved, the extrusion rod contracts through the elasticity of the elastic sheet when the reactor is separated from the inside of the sterilization frame, the telescopic lever pulls the clamping block through the push rod through the contraction of the extrusion rod, and the clamping block contacts with the inner ring surface of the circular block through the pulling of the push rod, so that the reactor is conveniently arranged in the sterilization frame, and convenience is improved.
When the sealing plate moves downwards, the sealing plate pushes the fixing frame to move downwards towards the lower part of the inner part of the reactor through the pressing rod, the fixing frame pushes liquid on the surface of the reactor downwards through the pressing pad when moving, when the liquid in the reactor is stored below the inner wall of the reactor, the liquid flows upwards through the contact part of the pressing pad and the inner wall of the reactor, slides down to the inner part of the storage frame through the inclination of the circular inclined plate for collection, and when the fixing frame moves upwards, the liquid in the reactor is pushed upwards through the pressing pad, so that the liquid slides down to the inner part of the storage frame for draining the liquid in the reactor.
When the fixing frame is stored below the inner part of the reactor through the extrusion pad, cotton fibers can absorb and collect liquid in the reactor, when the circular arc plate is contacted with the bottom of the inner wall of the reactor, the triangular block is contacted with the bottom of the inner wall of the reactor and can extrude the circular arc plate to shrink, the circular arc plate can extrude the cotton fibers to expand when shrinking, the adsorption capacity of the cotton fibers is increased, when the triangular block is separated from the bottom of the inner wall of the reactor, the circular arc plate can expand through the elasticity of the elastic sheet, and the cotton fibers can pass through the pressure of the separation and dispersion surface of the circular arc plate, so that the liquid in the cotton fibers is prevented from leaking.
When the arc plate is expanded through the elasticity of the elastic piece, the linkage rod is pulled by the arc plate to move downwards, the circular ring positioning rod is pulled by the cross rod to move downwards through the linkage rod, the elastic pressing rod is extruded to contract when the circular ring positioning rod moves downwards, when the arc pushing plate moves to the top of the reactor to be separated from the reactor, the arc pushing plate moves on the surface of the fixing frame through the expansion of the elastic pressing rod, the liquid on the surface of the fixing frame is fallen to the top of the fixing frame when the arc pushing plate moves, and the phenomenon that the liquid drops into the reactor to reduce the liquid discharging efficiency when the fixing frame is separated from the reactor is avoided.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present invention;
FIG. 2 is a schematic diagram of a cross-sectional front view of the sterilizing rack of the present invention;
FIG. 3 is a schematic view of the overall structure of the through-hole via frame of the present invention;
FIG. 4 is a schematic view of a partial cross-sectional structure of an arc block of the present invention;
FIG. 5 is a schematic elevational cross-sectional view of the reactor of the present invention;
FIG. 6 is a schematic diagram of a front cross-sectional structure of a fixing frame of the present invention;
FIG. 7 is a schematic elevational cross-sectional structural view of a cotton fiber of the present invention;
fig. 8 is a schematic diagram of the overall structure of the circular arc pushing plate of the present invention.
1. A sterilizing rack; 2. a top cover; 3. a sealing plate; 4. a circular groove; 5. an electric push rod; 6. a clamping mechanism; 7. a reactor; 8. a through hole frame; 9. a round hole; 10. a protective pad; 11. a high temperature sterilizer; 20. a circular ring block; 21. a push rod; 22. a bottom hole; 23. a clamping block; 24. a circular ring hole; 25. a positioning frame; 26. a semicircular rod; 27. a spring plate; 28. an extrusion rod; 29. a telescopic lever; 30. a compression bar; 31. a liquid pushing mechanism; 32. an extrusion mechanism; 33. an adsorption mechanism; 40. a fixing frame; 41. a storage rack; 42. a circular ring sloping plate; 43. a squeeze pad; 44. an extension hole; 45. a clamping groove; 50. an arc plate; 51. triangular blocks; 52. a connecting plate; 53. a connecting groove; 54. an elastic sheet; 55. cotton fibers; 60. a cross round hole; 61. a cross bar; 62. a circular ring positioning rod; 63. arc pushing plates; 64. a chute; 65. an arc pad; 66. an elastic compression bar; 67. a slide block; 68. and a linkage rod.
Detailed Description
The invention will be described in further detail with reference to the drawings and the detailed description. The embodiments of the invention have been presented for purposes of illustration and description, and are not intended to be exhaustive or limited to the invention in the form disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, and to enable others of ordinary skill in the art to understand the invention for various embodiments with various modifications as are suited to the particular use contemplated.
Example 1
Referring to fig. 1-7, the present invention is a sterile drain device for a bioreactor, comprising:
the sterilizing rack 1, wherein the sterilizing rack 1 is a cylinder with a deep groove, and the top of the sterilizing rack 1 is provided with a top cover 2;
the sealing plate 3 is circular, the top of the sealing plate 3 is fixedly connected with the bottom of the top cover 2, a clamping mechanism 6 is arranged in the sterilizing frame 1, a reactor 7 is arranged in the sterilizing frame 1, a circular groove 4 is formed in the top of the sterilizing frame 1, and an electric push rod 5 is fixedly connected with the bottom of the inner wall of the circular groove 4;
the bottom of the inner wall of the sterilizing frame 1 is fixedly connected with a through hole frame 8, a round hole 9 is formed in the top of the through hole frame 8, the inner wall of the round hole 9 is fixedly connected with a protection pad 10, and the bottom of the inner wall of the sterilizing frame 1 is fixedly connected with a high-temperature sterilizer 11;
the clamping mechanism 6 comprises a ring block 20, a push rod 21, a bottom hole 22, a clamping block 23, a ring hole 24, a positioning frame 25, a semicircular rod 26, an elastic sheet 27, a squeezing rod 28 and a telescopic lever 29, wherein the ring block 20 is fixedly connected with the inner wall of the sterilizing frame 1, the ring hole 24 is formed in the ring block 20, the bottom hole 22 is formed in the bottom of the ring block 20, the positioning frame 25 is fixedly connected with the inner wall of the sterilizing frame 1, the telescopic lever 29 is rotatably connected with the inner wall of the positioning frame 25 through a bearing, the elastic sheet 27 is fixedly connected with the bottom of the positioning frame 25 through the semicircular rod 26, the squeezing rod 28 is fixedly connected with the bottom of the telescopic lever 29, the clamping block 23 is fixedly connected with the top of the telescopic lever 29 through the push rod 21, when the reactor 7 is subjected to high-temperature sterilization, the high-temperature sterilizer 11 is started, the high-temperature sterilizer 11 is used for sterilizing the reactor through the through hole frame 8, the protective pad 10 is arranged in the circular hole 9 to support the bottom of the reactor 7, when the reactor 7 is pushed into the sterilizing frame 1, the reactor 7 pushes the squeezing rod 28 outwards, the squeezing rod 28 is pushed outwards through the bearing, the squeezing rod 28 is pushed outwards through the inner ring 21, the telescopic rod 28 is pushed by the telescopic rod 21, the telescopic rod is pushed by the telescopic rod 29, the inner ring 21 is pushed by the telescopic rod 21, the telescopic rod is pushed by the telescopic rod is separated from the inner ring 21, the inner ring 21 is pushed by the telescopic rod, the inner ring 21 is conveniently and the inner ring 7 is contacted with the telescopic rod is conveniently and rapidly pulled by the telescopic rod.
The top of the electric push rod 5 is fixedly connected with the bottom of the top cover 2, the bottom of the top cover 2 is contacted with the top surface of the sterilizing frame 1, the surface of the sealing plate 3 is contacted with the inner wall of the sterilizing frame 1, and the bottom surface of the reactor 7 is contacted with the inner ring of the protection pad 10.
One end of the elastic sheet 27, which is far away from the semicircular rod 26, is fixedly connected with the bottom surface of the telescopic lever 29, the positioning frame 25 is positioned below the circular ring block 20, the push rod 21 is arranged in the circular ring hole 24, the clamping block 23 is arranged at the inner ring of the circular ring block 20, and the telescopic lever 29 is obliquely arranged.
The bottom of closing plate 3 fixedly connected with depression bar 30, the bottom of depression bar 30 is provided with pushing equipment 31, and the inside of reactor 7 is provided with extrusion equipment 32, and the inner wall bottom of reactor 7 is provided with adsorption equipment 33.
The extrusion mechanism 32 comprises a fixing frame 40, a storage frame 41, a circular ring inclined plate 42, an extrusion pad 43, an extension hole 44 and a clamping groove 45, wherein the top of the fixing frame 40 is fixedly connected with the bottom of the compression rod 30, the storage frame 41 is fixedly connected with the fixing frame 40 through the circular ring inclined plate 42, the clamping groove 45 is formed in the lower surface of the fixing frame 40, and the extrusion pad 43 is fixedly connected with the inner wall of the clamping groove 45;
the bottom of the fixing frame 40 is provided with an extension hole 44, when the sealing plate 3 moves downwards, the sealing plate 3 pushes the fixing frame 40 to move downwards towards the lower part of the inside of the reactor 7 through the compression bar 30, when the fixing frame 40 moves downwards, liquid on the surface of the reactor 7 is pushed downwards through the compression pad 43, when the liquid in the inside of the reactor 7 is stored below the inner wall of the reactor 7, the liquid upwards flows through the contact part of the compression pad 43 and the inner wall of the reactor 7, slides to the inside of the storage frame 41 through the inclination of the circular inclined plate 42 for collection, and when the fixing frame 40 moves upwards, the liquid in the inside of the reactor 7 is pushed upwards through the compression pad 43, so that the liquid slides to the inside of the storage frame 41 for draining the inside of the reactor 7.
The end of the circular ring sloping plate 42, which is close to the storage rack 41, is arranged obliquely downwards, and one end of the extrusion pad 43, which is far away from the clamping groove 45, is fixedly connected with the surface of the fixed frame 40, and the storage rack 41 is arranged in the fixed frame 40.
The adsorption mechanism 33 comprises an arc plate 50, a triangular block 51, a connecting plate 52, a connecting groove 53, an elastic sheet 54 and cotton fibers 55, wherein the cotton fibers 55 are fixedly connected with the bottom of a fixing frame 40, the arc plate 50 is rotationally connected with the bottom of the fixing frame 40 through a rotating shaft, the triangular block 51 is fixedly connected with the bottom surface of the arc plate 50, the connecting groove 53 is formed in the center of the bottom of the cotton fibers 55, the end part of the arc plate 50 is hinged with the connecting plate 52, the arc plate 50 is fixedly connected with the elastic sheet 54, the elastic sheet 54 is fixedly connected with the bottom of the fixing frame 40, when the fixing frame 40 is stored below the inner part of the reactor 7 through a pressing pad 43, the cotton fibers 55 adsorb and collect liquid inside the reactor 7, when the arc plate 50 is contacted with the bottom of the inner wall of the reactor 7, the triangular block 51 is contacted with the bottom of the inner wall of the reactor 7 to squeeze the arc plate 50 to shrink, the cotton fibers 55 are squeezed and expanded when the arc plate 50 is shrunk, the adsorption capacity of the cotton fibers 55 is increased, when the triangular block 51 is separated from the bottom of the inner wall of the reactor 7, the arc plate 50 is elastically expanded through the elastic sheet 54, the cotton fibers 55 are dispersed through the pressure of the arc plate 50, and the liquid inside the cotton fibers 55 is prevented from leaking out;
the triangular block 51 is in contact with the bottom of the inner wall of the reactor 7.
The lower end of the extension hole 44 extends to the inside of the cotton fiber 55, and the bottom of the extension hole 44 communicates with the top of the connection groove 53.
Example 2
Referring to fig. 1-8, the present invention is a sterile drain device for a bioreactor, comprising:
the sterilizing rack 1, wherein the sterilizing rack 1 is a cylinder with a deep groove, and the top of the sterilizing rack 1 is provided with a top cover 2;
the sealing plate 3 is circular, the top of the sealing plate 3 is fixedly connected with the bottom of the top cover 2, a clamping mechanism 6 is arranged in the sterilizing frame 1, a reactor 7 is arranged in the sterilizing frame 1, a circular groove 4 is formed in the top of the sterilizing frame 1, and an electric push rod 5 is fixedly connected with the bottom of the inner wall of the circular groove 4;
the bottom of the inner wall of the sterilizing frame 1 is fixedly connected with a through hole frame 8, a round hole 9 is formed in the top of the through hole frame 8, the inner wall of the round hole 9 is fixedly connected with a protection pad 10, and the bottom of the inner wall of the sterilizing frame 1 is fixedly connected with a high-temperature sterilizer 11;
the clamping mechanism 6 comprises a ring block 20, a push rod 21, a bottom hole 22, a clamping block 23, a ring hole 24, a positioning frame 25, a semicircular rod 26, an elastic sheet 27, an extrusion rod 28 and a telescopic lever 29, wherein the ring block 20 is fixedly connected with the inner wall of the sterilizing frame 1, the ring hole 24 is formed in the ring block 20, the bottom hole 22 is formed in the bottom of the ring block 20, the positioning frame 25 is fixedly connected with the inner wall of the sterilizing frame 1, the telescopic lever 29 is rotatably connected with the inner wall of the positioning frame 25 through a bearing, the elastic sheet 27 is fixedly connected with the bottom of the positioning frame 25 through the semicircular rod 26, the extrusion rod 28 is fixedly connected with the bottom of the telescopic lever 29, and the clamping block 23 is fixedly connected with the top of the telescopic lever 29 through the push rod 21.
The top of the electric push rod 5 is fixedly connected with the bottom of the top cover 2, the bottom of the top cover 2 is contacted with the top surface of the sterilizing frame 1, the surface of the sealing plate 3 is contacted with the inner wall of the sterilizing frame 1, and the bottom surface of the reactor 7 is contacted with the inner ring of the protection pad 10.
One end of the elastic sheet 27, which is far away from the semicircular rod 26, is fixedly connected with the bottom surface of the telescopic lever 29, the positioning frame 25 is positioned below the circular ring block 20, the push rod 21 is arranged in the circular ring hole 24, the clamping block 23 is arranged at the inner ring of the circular ring block 20, and the telescopic lever 29 is obliquely arranged.
The bottom of closing plate 3 fixedly connected with depression bar 30, the bottom of depression bar 30 is provided with pushing equipment 31, and the inside of reactor 7 is provided with extrusion equipment 32, and the inner wall bottom of reactor 7 is provided with adsorption equipment 33.
The extrusion mechanism 32 comprises a fixing frame 40, a storage frame 41, a circular ring inclined plate 42, an extrusion pad 43, an extension hole 44 and a clamping groove 45, wherein the top of the fixing frame 40 is fixedly connected with the bottom of the compression rod 30, the storage frame 41 is fixedly connected with the fixing frame 40 through the circular ring inclined plate 42, the clamping groove 45 is formed in the lower surface of the fixing frame 40, and the extrusion pad 43 is fixedly connected with the inner wall of the clamping groove 45;
the bottom of the fixing frame 40 is provided with an extension hole 44.
The end of the circular ring sloping plate 42, which is close to the storage rack 41, is arranged obliquely downwards, and one end of the extrusion pad 43, which is far away from the clamping groove 45, is fixedly connected with the surface of the fixed frame 40, and the storage rack 41 is arranged in the fixed frame 40.
The adsorption mechanism 33 comprises an arc plate 50, a triangular block 51, a connecting plate 52, a connecting groove 53, an elastic sheet 54 and cotton fibers 55, wherein the cotton fibers 55 are fixedly connected with the bottom of the fixing frame 40, the arc plate 50 is rotationally connected with the bottom of the fixing frame 40 through a rotating shaft, the triangular block 51 is fixedly connected with the bottom surface of the arc plate 50, the connecting groove 53 is formed in the center of the bottom of the cotton fibers 55, the end part of the arc plate 50 is hinged with the connecting plate 52, the arc plate 50 is fixedly connected with the elastic sheet 54, and the elastic sheet 54 is fixedly connected with the bottom of the fixing frame 40;
the triangular block 51 is in contact with the bottom of the inner wall of the reactor 7.
The lower end of the extension hole 44 extends to the inside of the cotton fiber 55, and the bottom of the extension hole 44 communicates with the top of the connection groove 53.
The liquid pushing mechanism 31 comprises a cross round hole 60, a cross rod 61, a circular ring positioning rod 62, a circular arc push plate 63, a sliding chute 64, a circular arc pad 65, an elastic pressure rod 66, a sliding block 67 and a linkage rod 68, wherein the lower end of the inner wall of the pressure rod 30 is provided with the cross round hole 60, the cross rod 61 is arranged in the cross round hole 60, the circular ring positioning rod 62 is fixedly connected with the end part of the cross rod 61, the circular arc push plate 63 is rotationally connected with the circular ring positioning rod 62 through the elastic pressure rod 66, the circular arc pad 65 is fixedly connected with the surface of the circular arc push plate 63, the sliding chute 64 is arranged at the bottom of the circular arc push plate 63, the sliding block 67 is fixedly connected with the top of the fixed frame 40, when the circular arc plate 50 is expanded through the elasticity of the elastic sheet 54, the circular arc plate 50 can pull the linkage rod 68 downwards through the linkage rod 68, the circular ring positioning rod 62 can squeeze the elastic pressure rod 66 to shrink when the circular arc positioning rod 62 downwards moves, when the circular arc push plate 63 moves to the top of the reactor 7 to be separated from the reactor 7, the circular arc push plate 63 moves on the surface of the fixed frame through the expansion of the elastic pressure rod 66, when the circular arc push plate 63 moves to the top of the surface of the circular arc push plate 63 drops from the reactor 7 to the top of the reactor 7, and the liquid drop efficiency of the fixed frame is prevented from dropping down to the reactor 40 inside the reactor 7;
the top of the link 68 is fixedly connected to the bottom of the cross 61, and the lower surface of the link 68 is disposed inside the extension hole 44.
The bottom of the linkage rod 68 is hinged with the connecting plate 52, the cross rod 61 extends to the outer end of the compression bar 30 through the cross round hole 60, the arc pushing plate 63 is in sliding connection with the sliding block 67 through the sliding groove 64, and the arc pad 65 is in contact with the inner wall of the reactor 7.
One specific application of this embodiment is: when the reactor 7 needs to be sterilized at high temperature, the high-temperature sterilizer 11 is started, the high-temperature sterilizer 11 performs sterilization treatment on the reactor through the through hole frame 8, the protection pad 10 is arranged in the round hole 9 to support the bottom of the reactor 7, when the reactor 7 is pushed into the sterilizing frame 1, the reactor 7 pushes the extrusion rod 28 to expand outwards, the extrusion rod 28 pushes the push rod 21 to move in the circular hole 24 through the telescopic lever 29 during expansion, the clamping block 23 pushes the surface of the reactor 7 through the push rod 21, the stability of the reactor 7 during sterilization is improved, when the reactor 7 is separated from the inside of the sterilizing frame 1, the extrusion rod 28 is contracted through the elasticity of the elastic sheet 27, the telescopic lever 29 pulls the clamping block 23 through the push rod 21 through the contraction of the extrusion rod 28, the clamping block 23 is contacted with the inner ring surface of the circular block 20 through the pulling of the push rod 21, conveniently install reactor 7 in the inside of sterilizing rack 1, when closing plate 3 moves down, closing plate 3 can push mount 40 through depression bar 30 to the inside below of reactor 7, mount 40 is when moving through the liquid of extrusion pad 43 with reactor 7 surface to push down, when the liquid of reactor 7 inside is stored in the inner wall below of reactor 7, the liquid flows upwards through the contact department of extrusion pad 43 with the inner wall of reactor 7, through the slope of ring swash plate 42 the landing to the inside of storage rack 41 collect, when mount 40 is when moving upwards, the liquid of reactor 7 inside is pushed upwards through extrusion pad 43, the mount 40 is when storing in the inside below of reactor 7 through extrusion pad 43, cotton fiber 55 can adsorb the liquid of reactor 7 inside and collect, when circular arc board 50 contacts with the inner wall bottom of reactor 7, the triangular block 51 is contacted with the bottom of the inner wall of the reactor 7 to extrude the circular arc plate 50 to shrink, the circular arc plate 50 extrudes the cotton fiber 55 to expand when shrinking, the adsorption capacity of the cotton fiber 55 is increased, when the triangular block 51 is separated from the bottom of the inner wall of the reactor 7, the circular arc plate 50 can expand through the elasticity of the elastic sheet 54, the cotton fiber 55 is separated and dispersed through the pressure of the surface of the circular arc plate 50, when the circular arc plate 50 expands through the elasticity of the elastic sheet 54, the circular arc plate 50 can pull the linkage rod 68 to move downwards through the connecting plate 52, the cross rod 61 pulls the circular ring positioning rod 62 to move downwards through the linkage rod 68, the circular ring positioning rod 62 extrudes the elastic pressing rod 66 to shrink when moving downwards, when the circular arc pushing plate 63 moves to the top of the reactor 7 to be separated from the reactor 7, the circular arc pushing plate 63 moves on the surface of the fixing frame through the expansion of the elastic pressing rod 66, the circular arc pushing plate 63 drops liquid on the surface of the fixing frame to the top of the fixing frame 40 when moving, and the liquid drops to the inside the reactor 7 when the fixing frame 40 is prevented from being separated from the reactor 7, so that the efficiency of liquid is reduced.
It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. All other embodiments, which can be made by those skilled in the art and which are included in the embodiments of the present invention without the inventive step, are intended to be within the scope of the present invention. Structures, devices and methods of operation not specifically described and illustrated herein, unless otherwise indicated and limited, are implemented according to conventional means in the art.
Claims (3)
1. A sterile drain for a bioreactor, comprising:
the sterilizing rack (1), wherein the sterilizing rack (1) is a cylinder with a deep groove, and a top cover (2) is arranged at the top of the sterilizing rack (1);
the novel sterilizing device comprises a sealing plate (3), wherein the sealing plate (3) is circular, the top of the sealing plate (3) is fixedly connected with the bottom of a top cover (2), a clamping mechanism (6) is arranged in the sterilizing frame (1), a reactor (7) is arranged in the sterilizing frame (1), a circular groove (4) is formed in the top of the sterilizing frame (1), and an electric push rod (5) is fixedly connected to the bottom of the inner wall of the circular groove (4);
the sterilizing device is characterized in that a through hole frame (8) is fixedly connected to the bottom of the inner wall of the sterilizing frame (1), a round hole (9) is formed in the top of the through hole frame (8), a protection pad (10) is fixedly connected to the inner wall of the round hole (9), and a high-temperature sterilizer (11) is fixedly connected to the bottom of the inner wall of the sterilizing frame (1);
the clamping mechanism (6) comprises a circular block (20), a push rod (21), a bottom hole (22), a clamping block (23), a circular hole (24), a positioning frame (25), a semicircular rod (26), an elastic sheet (27), a squeezing rod (28) and a telescopic lever (29), wherein the circular block (20) is fixedly connected with the inner wall of the sterilizing frame (1), the circular hole (24) is formed in the circular block (20), the bottom hole (22) is formed in the bottom of the circular block (20), the positioning frame (25) is fixedly connected with the inner wall of the sterilizing frame (1), the telescopic lever (29) is rotatably connected with the inner wall of the positioning frame (25) through a bearing, the elastic sheet (27) is fixedly connected with the bottom of the positioning frame (25) through the semicircular rod (26), the squeezing rod (28) is fixedly connected with the bottom of the telescopic lever (29), and the clamping block (23) is fixedly connected with the top of the telescopic lever (29) through the push rod (21);
the bottom of the sealing plate (3) is fixedly connected with a pressing rod (30), the bottom of the pressing rod (30) is provided with a liquid pushing mechanism (31), the inside of the reactor (7) is provided with an extrusion mechanism (32), and the bottom of the inner wall of the reactor (7) is provided with an adsorption mechanism (33);
the extrusion mechanism (32) comprises a fixing frame (40), a storage frame (41), a circular ring inclined plate (42), an extrusion pad (43), an extension hole (44) and a clamping groove (45), wherein the top of the fixing frame (40) is fixedly connected with the bottom of the compression rod (30), the storage frame (41) is fixedly connected with the fixing frame (40) through the circular ring inclined plate (42), the clamping groove (45) is formed in the lower surface of the fixing frame (40), and the extrusion pad (43) is fixedly connected with the inner wall of the clamping groove (45);
an extension hole (44) is formed in the bottom of the fixing frame (40);
one end of the circular ring inclined plate (42) close to the storage frame (41) is obliquely downwards arranged, one end of the extrusion pad (43) far away from the clamping groove (45) is fixedly connected with the surface of the fixing frame (40), and the storage frame (41) is arranged in the fixing frame (40);
the adsorption mechanism (33) comprises an arc plate (50), a triangular block (51), a connecting plate (52), a connecting groove (53), an elastic sheet (54) and cotton fibers (55), wherein the cotton fibers (55) are fixedly connected with the bottom of the fixing frame (40), the arc plate (50) is rotationally connected with the bottom of the fixing frame (40) through a rotating shaft, the triangular block (51) is fixedly connected with the bottom surface of the arc plate (50), the connecting groove (53) is formed in the center of the bottom of the cotton fibers (55), the end part of the arc plate (50) is hinged with the connecting plate (52), the arc plate (50) is fixedly connected with the elastic sheet (54), and the elastic sheet (54) is fixedly connected with the bottom of the fixing frame (40);
the triangular block (51) is contacted with the bottom of the inner wall of the reactor (7);
the lower end of the extending hole (44) extends to the inside of the cotton fiber (55), and the bottom of the extending hole (44) is communicated with the top of the connecting groove (53);
the liquid pushing mechanism (31) comprises a cross round hole (60), a cross rod (61), a circular ring positioning rod (62), a circular arc pushing plate (63), a sliding groove (64), a circular arc pad (65), an elastic pressing rod (66), a sliding block (67) and a linkage rod (68), wherein the cross round hole (60) is formed in the lower end of the inner wall of the pressing rod (30), the cross rod (61) is arranged in the cross round hole (60), the circular ring positioning rod (62) is fixedly connected with the end part of the cross rod (61), the circular arc pushing plate (63) is rotatably connected with the circular ring positioning rod (62) through the elastic pressing rod (66), the circular arc pad (65) is fixedly connected with the surface of the circular arc pushing plate (63), the sliding groove (64) is formed in the bottom of the circular arc pushing plate (63), and the sliding block (67) is fixedly connected with the top of the fixing frame (40).
The top of the linkage rod (68) is fixedly connected with the bottom of the cross rod (61), and the lower surface of the linkage rod (68) is arranged in the extension hole (44);
the bottom of the linkage rod (68) is hinged with the connecting plate (52), the cross rod (61) extends to the outer end of the compression rod (30) through the cross round hole (60), the arc pushing plate (63) is in sliding connection with the sliding block (67) through the sliding groove (64), and the arc pad (65) is in contact with the inner wall of the reactor (7).
2. A sterile drain for a bioreactor according to claim 1, wherein: the top of electric push rod (5) and the bottom fixed connection of top cap (2), the bottom of top cap (2) and the top surface contact of sterilizing frame (1), the surface of closing plate (3) and the inner wall contact of sterilizing frame (1), the bottom surface of reactor (7) and the inner circle contact of protection pad (10).
3. A sterile drain for a bioreactor according to claim 1, wherein: one end of the elastic piece (27) far away from the semicircular rod (26) is fixedly connected with the bottom surface of the telescopic lever (29), the positioning frame (25) is located below the circular ring block (20), the push rod (21) is arranged in the circular ring hole (24), the clamping block (23) is arranged at the inner ring of the circular ring block (20), and the telescopic lever (29) is obliquely arranged.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210992079.5A CN115197813B (en) | 2022-08-17 | 2022-08-17 | Sterile drainage device for bioreactor |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210992079.5A CN115197813B (en) | 2022-08-17 | 2022-08-17 | Sterile drainage device for bioreactor |
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| CN115197813A CN115197813A (en) | 2022-10-18 |
| CN115197813B true CN115197813B (en) | 2023-10-03 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116042339A (en) * | 2023-01-10 | 2023-05-02 | 贵州省生物技术研究所(贵州省生物技术重点实验室、贵州省马铃薯研究所、贵州省食品加工研究所) | Solid-liquid dual-purpose brewing equipment for brewing waxberry fruit wine |
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| CN114455676A (en) * | 2022-01-25 | 2022-05-10 | 邹远洋 | Automatic sterilization and disinfection device for urban secondary water supply pump station and use method thereof |
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| WO2018105937A1 (en) * | 2016-12-09 | 2018-06-14 | 주식회사 이에스엔 | Device for sterilizing and drying container |
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| CN115197813A (en) | 2022-10-18 |
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