CN115192825A - Pre-filled and sealed injector and liquid storage device capable of generating different injection forces - Google Patents
Pre-filled and sealed injector and liquid storage device capable of generating different injection forces Download PDFInfo
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- CN115192825A CN115192825A CN202110901788.3A CN202110901788A CN115192825A CN 115192825 A CN115192825 A CN 115192825A CN 202110901788 A CN202110901788 A CN 202110901788A CN 115192825 A CN115192825 A CN 115192825A
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- plunger rod
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- syringe
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- 239000007788 liquid Substances 0.000 title claims abstract description 100
- 238000002347 injection Methods 0.000 title claims abstract description 72
- 239000007924 injection Substances 0.000 title claims abstract description 72
- 229940071643 prefilled syringe Drugs 0.000 claims abstract description 27
- 238000009434 installation Methods 0.000 claims description 6
- 230000033001 locomotion Effects 0.000 claims description 5
- 230000000903 blocking effect Effects 0.000 claims description 3
- 230000008602 contraction Effects 0.000 claims description 3
- 238000012377 drug delivery Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 13
- 230000008859 change Effects 0.000 description 11
- 230000008569 process Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 239000012530 fluid Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000000902 placebo Substances 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241001330002 Bambuseae Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3327—Measuring
Abstract
The invention relates to the field of drug delivery devices, in particular to a pre-filled syringe and a liquid storage device which generate different injection forces. The pre-filled and sealed syringe generating different injection forces comprises a syringe barrel, a plunger and a plunger rod assembly; the plunger may be connected to the plunger rod assembly, the connection of the plunger and the plunger rod assembly may be disposed within the syringe barrel; the plunger rod assembly is used for adjusting the pressure of the plunger acting on the syringe barrel in the radial direction to be one of the pressure threshold values. The pressure of the plunger acting on the syringe barrel before adjustment and the pressure of the plunger acting on the syringe barrel after adjustment are respectively one of the pressure threshold values through the plunger rod assembly, wherein one pressure forms the sum of the friction force and the liquid resistance generated by one liquid as a first resistance, the friction force formed by the other pressure forms the sum of the friction force and the liquid resistance generated by the other liquid as a second resistance, and the first resistance and the second resistance can be adjusted to be similar or identical.
Description
Technical Field
The invention relates to the field of drug delivery devices, in particular to a pre-filled syringe and a liquid storage device which generate different injection forces.
Background
In a double-blind test (double blind clinical trial), how to hide information is an important precondition for obtaining the accuracy of the double-blind test result.
In the process of double-blind experiments using syringes, two syringes of the same type are provided, and the subject cannot distinguish the difference between the two syringes per se from the appearance. However, when the first syringe is filled with the liquid of the first component and the second syringe is filled with the liquid of the second component, the liquid of the first component and the liquid of the second component have different viscosities, so that the test object can feel that the two injections have a distinct difference through the resistance of the syringes during the process of pushing the syringes to inject by the test object, which causes the information to be known to the test object through the touch.
In the above, in the case that the viscosities of the two liquids are different, the resistance of the injector is directly affected by the viscosities of the two liquids, so that the 'resistance of the injector filled with the liquid with higher viscosity' and the 'resistance of the injector filled with the liquid with lower viscosity' can be obviously sensed to be different.
Therefore, in the same type of syringe, how the resistance of the syringe filled with the liquid having a higher viscosity is set to be the same as the resistance of the syringe filled with the liquid having a lower viscosity becomes a technical problem to be solved in the prior art.
Disclosure of Invention
In order to solve the technical problem in the prior art, how to set the resistance of a syringe filled with a liquid with higher viscosity to be the same as the resistance of a syringe filled with a liquid with lower viscosity in the same type of syringe, the invention provides a pre-filled and sealed syringe and a liquid storage device which generate different injection forces.
In order to realize the purpose, the invention adopts the technical scheme that:
according to one aspect of the present invention, there is provided a pre-filled syringe producing different injection forces, comprising a syringe barrel, a plunger and a plunger rod assembly;
the plunger may be connected to the plunger rod assembly, and the junction of the plunger and the plunger rod assembly may be disposed within the syringe barrel;
the plunger rod assembly is used for adjusting the pressure of the plunger on the syringe barrel in the radial direction to be one of pressure threshold values.
Further, the plunger rod assembly comprises a first plunger rod and a second plunger rod;
one end of the first plunger rod is a first mounting end, one end of the second plunger rod is a second mounting end, and the diameter of the first mounting end is different from that of the second mounting end;
the first mounting end and the second mounting end are alternatively used for adjusting the pressure of the plunger acting on the syringe barrel in the radial direction to be one of pressure thresholds.
Further, the plunger is provided with a blind hole, and the opening direction of the blind hole is the axial direction of the plunger;
the first installation end and the second installation end are alternatively arranged in the blind hole.
Furthermore, an inner thread is arranged on the inner wall of the blind hole;
the first mounting end and the second mounting end are respectively provided with an external thread, and one of the external thread of the first mounting end and the external thread of the second mounting end is connected with the internal thread of the blind hole.
Further, the plunger rod assembly comprises a plunger rod sleeve and a plunger rod pin;
one end of the plunger rod sleeve is a deformation end, the plunger rod pin can be arranged in the plunger rod sleeve and can be inserted into the deformation end, and the deformation end inserted by the plunger rod pin is used for adjusting the pressure of the plunger acting on the syringe barrel in the radial direction to be one of pressure threshold values.
Furthermore, the deformation end is provided with at least two deformation positions, and a gap is formed between every two adjacent deformation positions;
when the plunger rod pin is inserted into the deformation end, any deformation position forms an expansion trend along the radial direction of the deformation end, and when the plunger rod pin moves out of the deformation end, any deformation position forms a contraction trend along the radial direction of the deformation end.
Furthermore, the other end of the plunger rod sleeve is a backstop end;
the backstop end is provided with a deformed state and a non-deformed state, and the plunger rod pin is used for forcing the backstop end to be converted between the deformed state and the non-deformed state;
when the plunger rod pin penetrates through the stopping end and is in a non-deformation state, the stopping end is used for blocking the movement of the plunger rod pin relative to the plunger rod sleeve.
Further, the inner contour of the deformation end is provided with a plurality of step parts, all the step parts are provided to be communicated coaxially, any one step part can form an inner end surface contour, and the axial inner end surface intervals of two adjacent inner end surface contours are the same;
the backstop end is provided with a plurality of deformable cantilever hooks, each cantilever hook is provided with a plurality of protrusions which are inward along the radial direction, and the axial protrusion intervals between two adjacent protrusions of each cantilever hook are the same;
the axial protrusion distance between two adjacent protrusions is the same as the axial inner end surface distance of two adjacent inner end surface profiles.
Furthermore, the injection needle also comprises a hollow injection needle;
the injection needle penetrates through and is fixedly arranged in the syringe barrel, wherein the two ends of the injection needle are respectively provided with a liquid inlet end and a liquid outlet end, the liquid outlet end is positioned outside the syringe barrel, and the liquid inlet end is positioned inside the syringe barrel.
According to one aspect of the present invention, there is provided a reservoir device comprising a pre-filled syringe as described above that generates different injection forces.
The technical scheme has the following advantages or beneficial effects:
according to the pre-filled syringe capable of generating different injection forces, the shape of the plunger is adjusted through the plunger rod assembly, so that the pressure of the plunger acting on the syringe barrel before adjustment and the pressure of the plunger acting on the syringe barrel after adjustment are respectively one of pressure threshold values, the sum of the friction force generated by one pressure and the liquid resistance generated by one liquid is used as a first resistance, the sum of the friction force generated by the other pressure and the liquid resistance generated by the other liquid is used as a second resistance, and the first resistance and the second resistance can be adjusted to be similar or identical.
Drawings
Fig. 1 is a schematic view of a split structure of a pre-filled and sealed syringe generating different injection forces according to embodiment 1 of the present invention;
fig. 2 is a schematic structural diagram of a pre-filled syringe generating different injection forces according to embodiment 1 of the present invention;
fig. 3 is a cross-sectional view of a pre-filled syringe producing different injection forces as provided in example 1 of the present invention;
FIG. 4 is a schematic structural view of a plunger and plunger rod assembly provided in embodiment 1 of the present invention;
FIG. 5 is a cross-sectional view of a plunger and plunger rod assembly provided in accordance with embodiment 1 of the present invention;
fig. 6 is a schematic view of a split structure of a pre-filled and sealed syringe generating different injection forces according to embodiment 2 of the present invention;
fig. 7 is a cross-sectional view of a pre-filled and sealed syringe generating different injection forces provided in example 2 of the present invention;
fig. 8 is a schematic structural view of a plunger rod sleeve provided in embodiment 2 of the present invention;
fig. 9 is a cross-sectional view of a plunger rod sleeve provided in embodiment 2 of the present invention;
fig. 10 is a schematic structural view of a plunger rod pin provided in embodiment 2 of the present invention;
fig. 11 is a cross-sectional view of a plunger and plunger rod assembly provided in embodiment 2 of the invention;
FIG. 12 is a cross-sectional view of a plunger and plunger rod assembly provided in accordance with embodiment 2 of the present invention;
fig. 13 is a cross-sectional view of a plunger and plunger rod assembly provided in example 2 of the present invention.
Detailed Description
The present invention provides a pre-filled syringe producing different injection forces, see fig. 1, 2, 6 or 7, comprising a syringe barrel 1, a plunger 2 and a plunger rod assembly 3;
the plunger 2 may be connected to the plunger rod assembly 3, and the connection between the plunger 2 and the plunger rod assembly 3 may be disposed within the syringe barrel 1;
the plunger rod assembly 3 is used for adjusting the pressure of the plunger 2 acting on the syringe barrel 1 in the radial direction to one of the pressure thresholds.
The plunger rod assembly 3 is used to push or pull the plunger 2 so that the plunger 2 can reciprocate within the syringe barrel 1; an accommodating cavity is formed between the inner wall of the syringe barrel 1 and the plunger 2, liquid can be accommodated in the accommodating cavity, and the liquid can move from the accommodating cavity to the outside of the accommodating cavity by the plunger rod assembly 3 pushing the plunger 2.
The plunger 2 exerts pressure on the syringe barrel 1 along the radial direction thereof, so that the plunger 2 can form a plunger 2 friction force relative to the syringe barrel 1; after the accommodation cavity of the syringe barrel 1 is filled with the liquid, the viscosity of the liquid acts on the inner wall of the syringe barrel 1, thereby forming liquid resistance; the plunger 2 friction force and the fluid resistance are each one of the resistances that the pre-filled syringe can feel or can be detected.
When the syringe barrel 1 is filled with liquid with higher viscosity, the liquid resistance is relatively increased, and if the friction force of the plunger 2 is kept unchanged, the resistance of the pre-filled syringe is increased;
when the syringe barrel 1 is filled with a less viscous liquid, the liquid resistance is relatively reduced, and if the plunger 2 friction force remains constant, the resistance of the pre-filled syringe is reduced.
From the above, if the 'resistance of the syringe filled with the liquid having a higher viscosity' and the 'resistance of the syringe filled with the liquid having a lower viscosity' are to be kept consistent, two modifications may be made:
first aspect, will originally the liquid that the viscidity is different reforms transform into the viscidity unanimously to make the liquid resistance when liquid is poured into in syringe section of thick bamboo 1 unanimous, under the unchangeable circumstances of plunger 2 frictional force, finally can realize that the resistance of syringe keeps unanimous effect.
In the second aspect, the effect of keeping the resistance of the syringe consistent is finally achieved by changing the friction force of the plunger 2 under the condition of not changing the viscosity of the liquid.
In the invention, the modification mode of the 'second aspect' is adopted, and the injector in the prior art is modified.
The plunger rod assembly 3 is connected with the plunger 2, and the plunger rod assembly 3 can change the radial shape of the plunger 2, so that the pressure acting on the syringe barrel 1 in the radial direction is changed;
if the plunger 2 and the plunger rod assembly 3 are respectively located outside the syringe barrel 1 before the plunger rod assembly 3 adjusts the radial shape of the plunger 2, the process by which the plunger rod assembly 3 can change the radial shape of the plunger 2 is visually observable; then, when the plunger 2 whose shape is changed is set in the syringe barrel 1, the plunger 2 is pressed by the syringe barrel 1 and the shape of the plunger 2 is changed again by the syringe barrel 1;
if the plunger 2 and the plunger rod assembly 3 are disposed within the syringe barrel 1 before the plunger rod assembly 3 adjusts the radial shape of the plunger 2, the process of changing the radial shape of the plunger 2 by the plunger rod assembly 3 cannot be visually observed; this is because the plunger 2 has already been constrained by the syringe barrel 1 so that the radially outer circumferential profile of the plunger 2 can only produce a 'tendency to change shape', while being substantially constrained by the syringe barrel 1 so that it cannot change shape and so cannot be visually observed; the radially inner part of the plunger 2 is in direct contact with the plunger rod assembly 3, and during the process that the plunger rod assembly 3 changes the radial shape of the plunger 2, the radially inner part of the plunger 2 is actually driven by the plunger rod assembly 3 to generate 'a trend of changing the shape', and meanwhile, a deformation process that the plunger 2 is pressed by the plunger rod assembly 3 along the radial direction is generated, and the deformation position is the radially inner part of the plunger 2, so that the radially inner part of the plunger 2 is shielded by the radially outer circumference of the plunger 2 and cannot be observed visually.
In the process of changing the shape of the plunger rod assembly 3 in the radial direction of the plunger 2, if the direction of the deformation or deformation tendency generated by the plunger 2 is in the direction from the inside to the outside of the plunger 2, the pressure applied to the syringe barrel 1 by the plunger 2 increases; conversely, if the direction of the deformation or the tendency of deformation generated by the plunger 2 is in the direction from the outside to the inside of the plunger 2, the pressure of the plunger 2 acting on the syringe barrel 1 decreases.
When the pressure applied to the syringe barrel 1 by the plunger 2 increases, the contact area between the plunger 2 and the syringe barrel 1 does not change, and the friction force between the plunger 2 and the syringe barrel 1 increases; conversely, when the pressure applied to the syringe barrel 1 by the plunger 2 is reduced, the contact area between the plunger 2 and the syringe barrel 1 is not changed, and the frictional force between the plunger 2 and the syringe barrel 1 is reduced.
It should be understood that the 'injection force' of the pre-filled syringe proposed by the present invention, which generates different injection forces, should be understood as: the thrust exerted by the user driving the plunger rod assembly 3 in motion relative to the syringe barrel 1 when using the prefilled syringe filled with liquid;
it should be understood that the pre-filled syringe that generates different injection forces, which 'generates different injection forces' proposed by the present invention should be understood as: when the user pushes the plunger rod assembly 3 before the pressure of the plunger 2 acting on the syringe barrel 1 is not changed by the plunger rod assembly 3, the pushing force applied by the user is a first injection force which is actually the sum of the friction force of the plunger 2 before the change and the liquid resistance; when the user pushes the plunger rod assembly 3 after the pressure of the plunger 2 acting on the syringe barrel 1 is changed by the plunger rod assembly 3, the pushing force applied by the user is a second injection force which is the sum of the friction force and the liquid resistance of the plunger 2 after the change; since the frictional force of the plunger 2 before the change is different from the frictional force of the plunger 2 after the change, the first injection force and the second injection force are different under the condition that the liquid resistance of the filled liquid is not changed.
The pre-filled and sealed injector capable of generating different injection forces provided by the invention can meet the following specific use scenes in the process of actually applying to the double-blind test:
using scenario a: the double-blind test is set to be two liquids, wherein the first liquid is a liquid medicine, the second liquid is a placebo, the viscosity of the first liquid is higher, the viscosity of the second liquid is lower, and the pre-filled and sealed injector which is provided by the invention and can generate different injection forces is adopted;
dividing pre-filled and sealed injectors generating different injection forces into two groups, wherein the first group of injectors are filled with a first liquid, and the second group of injectors are filled with a second liquid; before the shape of the syringe barrel 1 acted on by the plunger 2 is not changed by the plunger rod assembly 3, the first fluid resistance of the first fluid in the syringe barrel 1 of the first group of syringes is higher, the second fluid resistance of the second fluid in the syringe barrel 1 of the second group of syringes is lower, but the friction force of the first plunger 2 of the first group of syringes is the same as the friction force of the second plunger 2 of the second group of syringes, and the resistance force of the first group of syringes is larger than that of the second group of syringes; in this case, the second plunger 2 friction force of the second group of syringes may be increased, i.e. the shape of the plunger 2 is changed by the plunger rod assembly 3 of the second group of syringes, thereby increasing the second plunger 2 friction force of the second group of syringes; finally, the resistance of the first set of syringes may be set to be the same as the resistance of the second set of syringes.
Using scenario B: the double-blind test is set to be two liquids, wherein the first liquid is a liquid medicine, the second liquid is a placebo, the viscosity of the first liquid is higher, the viscosity of the second liquid is lower, and the pre-filled and sealed injector which is provided by the invention and can generate different injection forces is adopted;
dividing pre-filled and sealed injectors generating different injection forces into two groups, wherein the first group of injectors are filled with a first liquid, and the second group of injectors are filled with a second liquid; before the shape of the syringe barrel 1 acted on by the plunger 2 is not changed by the plunger rod assembly 3, the first fluid resistance of the first fluid in the syringe barrel 1 of the first group of syringes is higher, the second fluid resistance of the second fluid in the syringe barrel 1 of the second group of syringes is lower, but the friction force of the first plunger 2 of the first group of syringes is the same as the friction force of the second plunger 2 of the second group of syringes, and the resistance force of the first group of syringes is larger than that of the second group of syringes; in this case, the first plunger 2 friction force of the first group of syringes may be reduced, i.e. the plunger 2 shape is changed by the plunger rod assembly 3 of the first group of syringes, thereby reducing the first plunger 2 friction force of the first group of syringes; finally, the resistance of the first set of syringes may be set to be the same as the resistance of the second set of syringes.
Using scenario C: the double-blind test is set to be two kinds of liquid, the first liquid is a first liquid medicine, the second liquid is a second liquid medicine, the viscosity of the first liquid is higher, the viscosity of the second liquid is lower, and the pre-filled and sealed injector which is provided by the invention and can generate different injection forces is adopted;
in the present usage scenario C, except that the specific components of the two liquids are different from those in the usage scenario a, the remaining adjustment methods and effects are the same as those in the usage scenario a, and are not described herein again.
Using scenario D: the double-blind test is set to be two kinds of liquid, the first liquid is a first liquid medicine, the second liquid is a second liquid medicine, the viscosity of the first liquid is higher, the viscosity of the second liquid is lower, and the pre-filled and sealed injector which is provided by the invention and can generate different injection forces is adopted;
in the usage scenario D, except that the specific components of the two liquids are different from those in the usage scenario B, the rest of the adjustment methods and effects are the same as those in the usage scenario B, and are not described herein again.
In the actual design and manufacture of the pre-filled syringe of the present invention producing different injection forces, the pressure threshold of the plunger 2 acting on the syringe barrel 1 can be specifically measured and/or calculated according to the viscosity of the medicament or placebo required for the double blind trial; a pressure threshold should be understood as having a collection of pressure values.
For example: the pressure applied by the plunger 2 to the syringe barrel 1 before the plunger rod assembly 3 does not change the shape of the plunger 2 is a first pressure, the pressure applied by the plunger 2 to the syringe barrel 1 after the plunger rod assembly 3 changes the shape of the plunger 2 is a second pressure, the pressure threshold value should include the first pressure and the second pressure, and the maximum pressure of the pressure threshold value should be greater than or equal to the larger of the first pressure and the second pressure, and the minimum pressure of the pressure threshold value should be less than or equal to the smaller of the first pressure and the second pressure.
For another example: the pressure applied by the plunger 2 to the syringe barrel 1 before the plunger rod assembly 3 does not change the shape of the plunger 2 is a first pressure, and a second pressure, a third pressure, a fourth pressure \8230 \ 8230 \ N pressure, an N pressure, a pressure threshold value which should include the first pressure, the second pressure, the third pressure, the fourth pressure \8230 \ 8230 \ N pressure, and a maximum pressure in the pressure threshold value which should be greater than or equal to the greater of the first pressure and the N pressure, and a minimum pressure in the pressure threshold value which should be less than or equal to the lesser of the first pressure and the N pressure, may be formed during the plunger rod assembly 3 changing the plunger 2.
After measuring and/or calculating the pressure threshold of the plunger 2 acting on the syringe barrel 1, the specific structure of the plunger 2 and the specific structure of the plunger 2 stem matching the pressure threshold can be obtained by simple experiments, which is well known to the person skilled in the art and will not be described in detail here.
In the process of actually using the pre-filled syringe generating different injection forces according to the present invention, the shape of the plunger 2 is adjusted by the plunger rod assembly 3, so that the pressure applied to the syringe barrel 1 by the plunger 2 before adjustment and the pressure applied to the syringe barrel 1 by the plunger 2 after adjustment are respectively one of the pressure thresholds, wherein one of the pressure-forming friction forces and the liquid resistance generated by one of the liquids are respectively used as a first resistance, and the other of the pressure-forming friction forces and the liquid resistance generated by the other of the liquids are respectively used as a second resistance, and the first resistance and the second resistance can be adjusted to be similar or identical, thereby solving the technical problem in the prior art of how the resistance of the syringe filled with the higher viscosity liquid in the same type of syringe is set to be the same as the resistance of the syringe filled with the lower viscosity liquid.
The pre-filled syringe provided by the present invention to generate different injection forces is further described below by way of example.
Example 1:
in the present embodiment, referring to fig. 1-5, a pre-filled syringe generating different injection forces is provided, comprising a syringe barrel 1, a plunger 2 and a plunger rod assembly 3;
the plunger 2 may be connected to the plunger rod assembly 3, and the connection between the plunger 2 and the plunger rod assembly 3 may be provided in the syringe barrel 1;
the plunger rod assembly 3 is used for adjusting the pressure of the plunger 2 acting on the syringe barrel 1 in the radial direction to one of the pressure thresholds.
Wherein the plunger rod assembly 3 comprises a first plunger rod and a second plunger rod;
one end of the first plunger rod is a first mounting end, one end of the second plunger rod is a second mounting end, and the diameter of the first mounting end is different from that of the second mounting end;
the first mounting end and the second mounting end are selected to adjust the pressure of the plunger 2 acting on the syringe barrel 1 in the radial direction to one of the pressure thresholds.
The pre-filled syringe generating different injection forces in this embodiment has two plunger rod assemblies 3, which are respectively a first plunger rod and a second plunger rod, and the first plunger rod and the second plunger rod are different in that the diameter of the first mounting end of the first plunger rod is different from the diameter of the second mounting end of the second plunger rod, and the pressure applied to the syringe barrel 1 by the plunger 2 is changed by replacing the first plunger rod connected to the plunger 2 with the second plunger rod, or the pressure applied to the syringe barrel 1 by the plunger 2 is changed by replacing the second plunger rod connected to the plunger 2 with the first plunger rod.
It will be appreciated that the pressure applied to the syringe barrel 1 by the plunger 2 connected to the first plunger rod and the pressure applied to the syringe barrel 1 by the plunger 2 connected to the second plunger rod are each one of the pressure thresholds.
Referring to fig. 3 or 5, the plunger 2 is provided with a blind hole, and the opening direction of the blind hole is the axial direction of the plunger 2;
the first installation end and the second installation end are alternatively arranged in the blind hole.
The plunger 2 is provided with a blind hole structure, so that the blind hole can accommodate a first mounting end of a first plunger rod or accommodate a second mounting end of a second plunger rod, and the first mounting end and/or the second mounting end can force the plunger 2 to deform or tend to deform along a radial direction from the inside of the plunger 2 to the outside of the plunger 2.
The inner wall of the blind hole is provided with internal threads (not shown in the figure);
the first mounting end and the second mounting end are respectively provided with an external thread 301 (see fig. 1), and the external thread 301 of the first mounting end and the external thread 301 of the second mounting end are alternatively connected with the internal thread of the blind hole.
The blind hole is arranged to be an internal threaded hole, and the first mounting end and the second mounting end are respectively provided with the external threads 301, so that the positioning and connection of the first mounting end and the second mounting end relative to the blind hole can be simplified, and the first plunger rod and the second plunger rod can be conveniently connected to the plunger 2; in addition, the internal thread of the blind hole is connected with the external thread 301 of the first plunger rod or the second plunger rod, so that the negative effect of separation of the first plunger rod or the second plunger rod relative to the plunger 2 can be reduced or avoided in the process of pulling the plunger 2 by the first plunger rod or the second plunger rod.
Referring to fig. 1 to 3, the pre-filled syringe, which generates different injection forces, further comprises a hollow-shaped injection needle 4;
the injection needle 4 penetrates and is fixedly arranged in the syringe barrel 1, wherein two ends of the injection needle 4 are respectively a liquid inlet end and a liquid outlet end, the liquid outlet end is positioned outside the syringe barrel 1, and the liquid inlet end is positioned inside the syringe barrel 1.
The connection between the syringe barrel 1 and the injection needle 4 can be made by the prior art and will not be described in detail herein.
Example 2:
in the present embodiment, referring to fig. 6-13, a pre-filled syringe that produces different injection forces is provided, comprising a syringe barrel 1, a plunger 2, and a plunger rod assembly 3;
the plunger 2 may be connected to the plunger rod assembly 3, and the connection between the plunger 2 and the plunger rod assembly 3 may be provided in the syringe barrel 1;
the plunger rod assembly 3 is used for adjusting the pressure of the plunger 2 acting on the syringe barrel 1 in the radial direction to one of the pressure thresholds.
Referring to fig. 6 to 13, plunger rod assembly 3 includes plunger rod sleeve 310 and plunger rod pin 311;
one end of the plunger rod sleeve 310 is a deformed end 312, the plunger rod pin 311 can be arranged in the plunger rod sleeve 310, the plunger rod pin 311 can be inserted into the deformed end 312, and the deformed end 312 inserted by the plunger rod pin 311 is used for adjusting the pressure of the plunger 2 acting on the syringe barrel 1 in the radial direction to be one of the pressure thresholds.
In the pre-filled syringe generating different injection forces in the present embodiment, the plunger rod assembly 3 is set to be adjustable, specifically: the plunger rod sleeve 310 is sleeved with the plunger rod pin 311, and the plunger rod pin 311 is located at different positions relative to the plunger rod sleeve 310, so that the deformation end 312 inserted by the plunger rod pin 311 generates different deformation or deformation trends, and further the pressure of the plunger 2 acting on the syringe barrel 1 is changed.
Specifically, referring to fig. 8 or 9, the deformation end 312 is provided with at least two deformation positions X, and a gap is formed between two adjacent deformation positions X;
when the plunger rod pin 311 is inserted into the deformation end 312, any deformation X has an expansion tendency along the radial direction of the deformation end 312, and when the plunger rod pin 311 is moved out of the deformation end 312, any deformation X has a contraction tendency along the radial direction of the deformation end 312.
Where deformation X is understood to be a portion of plunger rod sleeve 310, plunger rod pin 311 may actually contact the inner surface of deformation X when plunger rod pin 311 is inserted into deformation end 312, such that plunger rod pin 311 may apply a radial force to deformation X to force deformation X.
It should be appreciated that the deformation site X is in the first state before the plunger rod pin 311 is inserted into the deformed end 312; at this time, a gap should be formed between two adjacent deformation positions X, so that when the plunger 2 is pressed by the acting force of the syringe barrel 1, the deformation positions X can be slightly deformed inwards along the radial direction; or, at this time, a gap should be formed between two adjacent deformation positions X, but no deformation is generated at any one of the deformation positions X.
It should be understood that after the plunger rod pin 311 is inserted into the deformation end 312, the deformation site X may be in the first state or in the second state; when the deformation position X is in the first state, the acting force applied to the deformation position X by the plunger rod pin 311 is smaller and is not enough to cause the deformation position X to generate deformation, or when the deformation position X is in the first state, the acting force applied to the deformation position X by the plunger rod pin 311 is smaller, and the deformation position X generates a deformation trend but is not deformed under the influence of the acting force of the syringe barrel 1; when the deformation X is in the second state, it means that the acting force applied to the deformation X by the plunger rod pin 311 is large enough to cause the deformation X to generate a deformation or deformation trend from the inside of the plunger 2 to the outside of the plunger 2 along the radial direction, so that the deformation X is changed from the first state to the second state at this time, and the gap at this time is influenced by the deformation of the deformation X and tends to increase.
Further, referring to fig. 7 to 9 and 11 to 13, the other end of the plunger rod sleeve 310 is a stopping end 313;
the backstop end 313 has a deformed state and an undeformed state, and the plunger rod pin 311 is used for forcing the backstop end 313 to be transformed between the deformed state and the undeformed state;
when plunger rod pin 311 penetrates retaining end 313 and plunger rod pin 311 is in an undeformed state, retaining end 313 serves to block movement of plunger rod pin 311 relative to plunger rod sleeve 310.
Further, referring to fig. 9, 11 to 13, the inner contour of the deformation end 312 is configured as a plurality of steps, all the steps are configured to be communicated coaxially, any one step can form an inner end surface contour, and the axial inner end surface intervals of two adjacent inner end surface contours are the same;
the retaining end 313 is provided with a plurality of deformable cantilever hooks, each cantilever hook is provided with a plurality of protrusions which are inward along the radial direction, and the axial protrusion intervals between two adjacent protrusions of each cantilever hook are the same;
the axial protrusion distance between two adjacent protrusions is the same as the axial inner end surface distance of two adjacent inner end surface profiles.
Wherein the inner end surface profile of either step is penetrable by the plunger rod pin 311, respectively, and one end of the plunger rod pin 311 may contact the inner end surface profile of either step;
the inner diameters of the multiple steps are gradually reduced along the direction from the retaining end 313 to the deformation end 312, that is, the inner diameter of the inner end surface profile close to the retaining end 313 is larger, and the inner diameter of the inner end surface profile far from the retaining end 313 is smaller, so that in the process that one end of the plunger rod pin 311 penetrates through the multiple inner end surface profiles respectively, the acting force applied to the deformation end 312 by the plunger rod pin 311 is gradually increased, so that the acting force applied to the plunger 2 by the deformation end 312 forms multiple acting forces, and the plunger 2 forms multiple deformations according to the acting forces, and the acting force applied to the syringe barrel 1 by the plunger 2 is changed into multiple actions.
Referring to fig. 11, plunger rod pin 311 is in a first position relative to plunger rod sleeve 310, wherein one of the ends of plunger rod pin 311 contacts the inner end face profile at the proximal first step;
referring to fig. 12, plunger rod pin 311 is in a first position relative to plunger rod sleeve 310, wherein one of the ends of plunger rod pin 311 contacts the inner end face profile of the second step at the middle;
referring to fig. 13, plunger rod pin 311 is in a first position relative to plunger rod sleeve 310, wherein one of the ends of plunger rod pin 311 contacts the inner end face profile of the third step that is furthest away;
the contact of the plunger rod pin 311 with the contour of the inner end surface of the different step portions may cause the diameter of the deformed end to be different, and thus the deformation or the deformation tendency of the plunger 2 is different, thereby causing the friction force of the plunger 2 acting on the syringe barrel 1 to be different.
When one of the ends of the plunger rod pin 311 contacts the inner end face profile of one of the steps, the plunger rod pin 311 is actually trapped between the deformed end 312 and the backstop end 313, such that the plunger rod pin 311 cannot move axially relative to the plunger rod sleeve 310; specifically, one end of the plunger rod pin 311 is blocked by the inner end surface profile, the plunger rod pin 311 cannot move along the direction from the retaining end 313 to the deformation end 312 without receiving an additional external force, and the other end of the plunger rod pin 311 is restricted by two adjacent protrusions on the plurality of cantilever hooks, so that the axial reaction force of the plunger 2 acting on the plunger rod pin 311 is offset, and the plunger rod pin 311 cannot move along the direction from the deformation end 312 to the retaining end 313. In practical applications, the position of one end of the plunger rod pin 311 relative to the contour of the inner end surface of any one of the stepped portions is a regulation mode for regulating the acting force of the plunger 2 on the syringe barrel 1; in other words, for the purpose of applying sufficient and reasonable pressure to the syringe barrel 1 by the plunger 2, it is necessary to limit one of the ends of the plunger rod sleeve 310 to a state 'of contacting the inner end face profile of one of the stepped portions', at which time the other end of the plunger rod sleeve 310 should be restrained by two of the adjacent protrusions of either one of the cantilever hooks; therefore, it is necessary to set the interval between the adjacent two projections of any one of the cantilever hooks to be the same as the interval between the inner end surface profiles of the adjacent two stepped portions.
In the present embodiment, referring to fig. 6 or 7, the pre-filled syringe generating different injection forces further includes a hollow injection needle 4;
the injection needle 4 penetrates and is fixedly arranged in the syringe barrel 1, wherein two ends of the injection needle 4 are respectively a liquid inlet end and a liquid outlet end, the liquid outlet end is positioned outside the syringe barrel 1, and the liquid inlet end is positioned inside the syringe barrel 1.
The connection between the syringe barrel 1 and the injection needle 4 can be made by the prior art and will not be described in detail herein.
Example 3:
in this embodiment, a reservoir is provided comprising a pre-filled syringe generating different injection forces as in the previous embodiment 1 or 2.
The reservoir is a pre-filled syringe producing different injection forces for filling liquids, such as: automatic injection devices with pre-filled syringes generating different injection forces, manual injection devices with pre-filled syringes generating different injection forces, medicament containers with pre-filled syringes generating different injection forces, etc.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and all equivalent structural changes made by using the contents of the specification and drawings, or any other related technical fields, are all included in the scope of the present invention.
Claims (10)
1. A pre-filled syringe producing different injection forces, comprising a syringe barrel, a plunger and a plunger rod assembly;
the plunger may be connected to the plunger rod assembly, and the junction of the plunger and the plunger rod assembly may be disposed within the syringe barrel;
the plunger rod assembly is used for adjusting the pressure of the plunger on the syringe barrel in the radial direction to be one of pressure thresholds.
2. The pre-filled and sealed syringe generating different injection forces according to claim 1, wherein the plunger rod assembly comprises a first plunger rod and a second plunger rod;
one end of the first plunger rod is a first mounting end, one end of the second plunger rod is a second mounting end, and the diameter of the first mounting end is different from that of the second mounting end;
the first mounting end and the second mounting end are alternatively used for adjusting the pressure of the plunger acting on the syringe barrel in the radial direction to be one of pressure thresholds.
3. The pre-filled and sealed injector generating different injection forces according to claim 2, characterized in that the plunger is provided with a blind hole, the opening direction of the blind hole is the axial direction of the plunger;
one of the first installation end and the second installation end is arranged in the blind hole.
4. The pre-filled and sealed injector generating different injection forces according to claim 3, characterized in that the inner wall of the blind hole is provided with an internal thread;
the first mounting end and the second mounting end are respectively provided with an external thread, one of the external thread of the first mounting end and the external thread of the second mounting end is selected to be connected with the internal thread of the blind hole.
5. The pre-filled and sealed syringe generating different injection forces according to claim 1, wherein the plunger rod assembly comprises a plunger rod sleeve and a plunger rod pin;
one end of the plunger rod sleeve is a deformation end, the plunger rod pin can be arranged in the plunger rod sleeve and can be inserted into the deformation end, and the deformation end inserted by the plunger rod pin is used for adjusting the pressure of the plunger acting on the syringe barrel in the radial direction to be one of pressure threshold values.
6. The pre-filled and sealed syringe generating different injection forces according to claim 5, wherein the deformation end is provided with at least two deformation parts, and a gap is formed between two adjacent deformation parts;
when the plunger rod pin is inserted into the deformation end, any deformation position forms an expansion trend along the radial direction of the deformation end, and when the plunger rod pin moves out of the deformation end, any deformation position forms a contraction trend along the radial direction of the deformation end.
7. The pre-filled and sealed syringe generating different injection forces according to claim 6, wherein the other end of the plunger rod sleeve is a backstop end;
the backstop end is provided with a deformation state and a non-deformation state, and the plunger rod pin is used for forcing the backstop end to be converted between the deformation state and the non-deformation state;
when the plunger rod pin penetrates through the stopping end and is in a non-deformation state, the stopping end is used for blocking the movement of the plunger rod pin relative to the plunger rod sleeve.
8. The pre-filled and sealed syringe generating different injection forces according to claim 7, wherein the inner contour of the deformation end is configured as a plurality of steps, all of the steps are configured to be coaxially communicated, any one of the steps can form an inner end surface contour, and the axial inner end surface intervals of two adjacent inner end surface contours are the same;
the backstop end is provided with a plurality of deformable cantilever hooks, each cantilever hook is provided with a plurality of protrusions which are inward along the radial direction, and the axial protrusion intervals between two adjacent protrusions of each cantilever hook are the same;
the axial protrusion distance between two adjacent protrusions is the same as the axial inner end surface distance of two adjacent inner end surface profiles.
9. The pre-filled and sealed syringe generating different injection forces according to any one of claims 1 to 8, further comprising an injection needle having a hollow shape;
the injection needle penetrates through and is fixedly arranged in the syringe barrel, wherein the two ends of the injection needle are respectively provided with a liquid inlet end and a liquid outlet end, the liquid outlet end is positioned outside the syringe barrel, and the liquid inlet end is positioned inside the syringe barrel.
10. Reservoir comprising a pre-filled syringe generating different injection forces according to any one of claims 1 to 9.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163258120P | 2021-04-13 | 2021-04-13 | |
| US63/258,120 | 2021-04-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115192825A true CN115192825A (en) | 2022-10-18 |
| CN115192825B CN115192825B (en) | 2024-04-30 |
Family
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| CA2808875A1 (en) * | 2013-03-08 | 2014-09-08 | Teva Pharmaceutical Industries Ltd. | Re-useable injector device for syringe |
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| US4194505A (en) * | 1978-09-15 | 1980-03-25 | Vac-O-Cast, Inc. | Containerized hypodermic module |
| US4452251A (en) * | 1982-11-05 | 1984-06-05 | Medrad, Inc. | Syringe content indicating device |
| JPH0648677U (en) * | 1992-12-15 | 1994-07-05 | 毅 青木 | Gravity-type automatic intravenous injection device flow measurement and adjustment device |
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