CN115178162A - Online buffer solution preparation magnetic mixer - Google Patents
Online buffer solution preparation magnetic mixer Download PDFInfo
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- CN115178162A CN115178162A CN202210819300.7A CN202210819300A CN115178162A CN 115178162 A CN115178162 A CN 115178162A CN 202210819300 A CN202210819300 A CN 202210819300A CN 115178162 A CN115178162 A CN 115178162A
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- 239000007853 buffer solution Substances 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 238000002156 mixing Methods 0.000 claims abstract description 49
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 27
- 239000012530 fluid Substances 0.000 claims abstract description 14
- 238000003760 magnetic stirring Methods 0.000 claims abstract description 9
- 238000004804 winding Methods 0.000 claims abstract description 9
- 230000000694 effects Effects 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 7
- 230000002411 adverse Effects 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 3
- 238000007667 floating Methods 0.000 claims description 2
- 238000009827 uniform distribution Methods 0.000 claims 2
- 238000005339 levitation Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 abstract description 6
- 238000004587 chromatography analysis Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 18
- 239000000243 solution Substances 0.000 description 11
- 239000000872 buffer Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 238000013375 chromatographic separation Methods 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000013019 agitation Methods 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000009775 high-speed stirring Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/80—After-treatment of the mixture
- B01F23/808—Filtering the mixture
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
- B01F35/2214—Speed during the operation
- B01F35/22142—Speed of the mixing device during the operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/222—Control or regulation of the operation of the driving system, e.g. torque, speed or power of motors; of the position of mixing devices or elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
Abstract
The embodiment of the present specification provides an on-line buffer solution preparation magnetic mixer, which is used for laboratory chromatography buffer solution preparation, and comprises: has a housing 3; the housing having opposite upstream and downstream ends, the upstream end 8 comprising a fluid inlet 81 and a passage 82, the downstream end 1 comprising a fluid outlet 14 and a passage 13; an upstream end portion 8, which is movably fixed inside the housing 3 by means of a seal of the O-ring 9, defines the volume of the mixing chamber 15; a magnetic rotor 4 is arranged in the mixing chamber, and the rotor and the stator 5 are designed for bearingless magnetic stirring; a filter is arranged at the outlet of the mixing cavity; the stirring speed can be conveniently controlled by controlling the current of the winding, and no rotating motion part is arranged outside the mixer; the volume of the mixing cavity can be conveniently adjusted by adjusting the positioning nut, so that the mixing device is suitable for different flow ranges, mixers with different volumes do not need to be replaced, the mixing efficiency is improved, and the use cost is reduced.
Description
Technical Field
The specification relates to the technical field of chromatography, in particular to an online buffer solution preparation magnetic mixer.
Background
In the biopharmaceutical process, especially in the chromatographic separation step, buffers with different ion concentrations are required to elute and wash target proteins, and because the required buffers are usually in various types and are small in single-batch dosage, each solution is separately prepared, which causes huge waste of manpower and material resources, and the common method is to prepare the target proteins by a basic method of directly blending several solutions on line. However, for the solutions on a laboratory scale, since the flow rate of each solution is extremely low, the direct blending method cannot currently achieve the required accuracy at all, and therefore the method is adopted in which the time for pumping each solution is calculated according to the required concentration by controlling the time, the pumping is performed at intervals, and then the solutions are mixed downstream.
Common mixing methods include static mixing, and mechanical agitation mixing.
However, static mixing has a large relationship with flow, and the mixing effect is also greatly different due to flow variation, so that a stable process cannot be formed; in addition, the cleaning and cleaning verification of the mixer is a difficult problem.
In the mechanical stirring mode, magnetic stirring is the most commonly used mode, the magnetic stirring mode is that the impeller rotor in the cavity is driven to rotate by the rotation of the external stator magnet, so that a rotating part is required to be arranged outside the mixer, and additional requirements are provided for the structure of the mixer; in addition, this method does not allow a good control of the rotor suspension in the cavity, and there may be friction between the rotor and the cavity surface as it rotates, thereby causing particles to clog downstream membranes or gels, among other adverse effects.
The conventional magnetic stirring described above also has a very limited number of stirring speeds, which limits the mixing efficiency.
Furthermore, it is the experimental nature that the flow rates used will be a wide range, and the time-shared feed method used, in essence, utilizes the concept of residence time, which requires different chamber volumes for different flow rates to establish different residence times while ensuring minimal system dead volume. Current devices provide a fixed volume, which requires additional cost to replace mixers of different volumes.
Disclosure of Invention
In order to solve the problems in the background art, embodiments of the present disclosure provide an online buffer solution dispensing mixer, which provides magnetic stirring without external operating components by using the principle of a bearingless motor, and can adjust the volume of a mixing chamber as required, thereby providing a simple and convenient laboratory tool.
The embodiment of the specification provides the following technical scheme: an on-line buffer dispensing magnetic mixer, comprising:
has a housing 3; the housing having opposite upstream and downstream ends, the upstream end 8 comprising a fluid inlet 81 and a passage 82, the downstream end 1 comprising a fluid outlet 14 and a passage 13; an upstream end portion 8 is movably fixed to the housing 3 by means of a seal of an O-ring 9, said movable upstream end portion defining the volume of the mixing chamber 15; a magnetic stirrer rotor 4 is arranged in the mixing chamber, said rotor comprising a permanent magnet active core and a sheath of thermoplastically processable polymer containing a blade structure; the stator 5 is designed as a bearing stator and a driver stator, both of the stator of an electric drive and of a magnetic bearing, the electrical windings of which can be used to generate a rotating magnetic field which, on the one hand, exerts a torque on the rotor causing it to rotate and, on the other hand, exerts a freely adjustable transverse force on the rotor so that its radial position can be actively controlled or modulated; the outlet of the mixing cavity is provided with a filter, and the filter assembly comprises filter sieve plates 11 and 16 and a filter membrane 10.
Preferably, the rotor is designed in a ring shape, and a through hole connecting the upstream and the downstream is designed in the center and is used for balancing the pressure of the upstream and the downstream.
Preferably, the end surface of the upstream end portion 8 facing the chamber has a domed floor 85 adapted for radial distribution of the fluid in the cavity.
Preferably, the end surface of the downstream end portion 1 facing the chamber has a domed floor 12 adapted for radial distribution of the fluid in the chamber.
Preferably, said upstream end portion 8 is kept sealed against the movement of the casing 3 by means of an o-ring 9.
Preferably, said upstream end 8 is positioned by means of a positioning nut 6 and a thread 86 of the casing 3, by locking of the locking nut 7, so as to adjust and fix the volume of the mixing chamber.
Preferably, the downstream end 1 and the housing 3 are locked to each other by a fastening nut 2 on the housing 3.
Preferably, said magnetic stirring, wherein the stator 5 and the rotor 4 form a bearingless motor, the rotor 4 is actively controllable and drivable with respect to three degrees of freedom by means of electric windings 51, and the rotor 4 and the stator teeth are designed in a geometric distribution with respect to each other and are arranged opposite each other, so that the rotor 4 can be held in the stator 5 by means of passively acting reluctance forces, positioning the rotor 4 in the cavity 15 of the housing 3 in a zero-contact drivable and floating manner, while at the same time avoiding friction with the inner walls of the cavity in a narrow mixing cavity to produce adverse effects and enabling high-speed mixing to be achieved.
Compared with the prior art, the beneficial effects that can be achieved by the at least one technical scheme adopted by the embodiment of the specification at least comprise:
the stirring rotating speed can be conveniently controlled by controlling the current of the winding, and can reach higher rotating speed, and no rotating moving part is arranged outside the cavity of the mixer; the volume of the mixing cavity can be conveniently adjusted by adjusting the positioning nut, so that the mixing device is suitable for different flow ranges, mixers with different volumes do not need to be replaced, the mixing efficiency is improved, and the use cost is reduced.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic diagram of a two-dimensional structure of an on-line buffer solution preparation magnetic mixer provided by the invention;
FIG. 2 is a schematic diagram of a three-dimensional explosion structure of an on-line buffer solution preparation magnetic mixer provided by the present invention;
FIG. 3 is a schematic diagram of a three-dimensional rotor structure of an on-line buffer solution preparation magnetic mixer provided by the present invention;
FIG. 4 is a schematic diagram of a three-dimensional housing structure of an on-line buffer solution preparation magnetic mixer provided by the present invention;
FIG. 5 is a schematic diagram of the three-dimensional shape structure of an on-line buffer solution preparation magnetic mixer provided by the invention.
Detailed Description
Embodiments of the present application are described in detail below with reference to the accompanying drawings.
The following description of the embodiments of the present application is provided by way of specific examples, and other advantages and effects of the present application will be readily apparent to those skilled in the art from the disclosure herein. It is to be understood that the embodiments described are only a few embodiments of the present application and not all embodiments. The present application is capable of other and different embodiments and its several details are capable of modifications and/or changes in various respects, all without departing from the spirit of the present application. It is to be noted that the features in the following embodiments and examples may be combined with each other without conflict. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It is noted that various aspects of the embodiments are described below within the scope of the appended claims. It should be apparent that the aspects described herein may be embodied in a wide variety of forms and that any specific structure and/or function described herein is merely illustrative. Based on the present application, one skilled in the art should appreciate that one aspect described herein may be implemented independently of any other aspects and that two or more of these aspects may be combined in various ways. For example, an apparatus may be implemented and/or a method practiced using any number and aspects set forth herein. Additionally, such an apparatus may be implemented and/or such a method may be practiced using other structure and/or functionality in addition to one or more of the aspects set forth herein.
It should be noted that the drawings provided in the following embodiments are only for illustrating the basic idea of the present application, and the drawings only show the components related to the present application rather than the number, shape and size of the components in actual implementation, and the type, amount and ratio of the components in actual implementation may be changed arbitrarily, and the layout of the components may be more complicated.
In addition, in the following description, specific details are provided to facilitate a thorough understanding of the examples. However, it will be understood by those skilled in the art that the aspects may be practiced without these specific details.
At present, the following problems mainly exist in the preparation of buffer solution in the process of experimental scale chromatographic separation:
1. the static mixing method has a great relationship with the flow, and the mixing effect is also greatly different due to the flow change, so that a stable process cannot be formed; in addition, cleaning and validation of cleanliness of the mixer is a difficult problem.
2. The commonly used magnetic stirring mode is that the impeller rotor in the cavity is driven to rotate by the rotation of the external stator magnet, so that a rotating part needs to be arranged outside the mixer, and additional requirements are provided for the structure of the mixer; in addition, this method does not provide a good control of the rotor suspension in the chamber, and there may be friction between the rotor and the inner chamber surface as it rotates, thereby causing adverse effects such as particles and clogging of downstream membranes or colloids.
3. The conventional magnetic stirring described above also has a very limited number of stirring speeds, which limits the mixing efficiency.
4. Since the essential nature of the experiment is that the flow rates used will be over a wide range, the time-shared feed method used is essentially based on the concept of residence time, which requires different chamber volumes for different flow rates to establish different residence times while ensuring minimum system dead volume. Current devices provide a fixed volume, which requires additional cost to replace mixers of different volumes.
The inventors have made extensive and intensive experiments to provide an on-line buffer dispensing magnetic mixer whereby controllable mixing efficiency, and adjustable mixing chamber volume, provide great convenience.
The invention solves the technical problems of no bearing stirring of an external rotating part, higher stirring speed and adjustable volume of a mixing cavity.
More specifically, the solution adopted by the invention comprises: the rotating speed and the position of the rotor can be controlled through the current control of the electric winding; the volume of the mixing chamber can be easily changed through thread adjustment, so that the mixing requirement of buffer solutions with different flow scales is met, and the process safety and the operation convenience are greatly guaranteed.
The technical solutions provided by the embodiments of the present application are described below with reference to the accompanying drawings.
As shown in fig. 1 and 2, an on-line buffer solution preparing magnetic mixer comprises:
having a housing 3 providing a mixing chamber and accommodating other accessories upstream and downstream; the shell is provided with opposite upstream and downstream ends, the upstream end 8 comprises a fluid inlet 81 and a channel 82, the downstream end 1 comprises a fluid outlet 14 and a channel 13, fluid enters the mixing cavity from the inlet 81 and flows out from the outlet 14 after being stirred and mixed; the upstream end 8 is removably fixed in the housing 3 by means of the seal of the O-ring 9, said removable upstream end defining the volume of the mixing chamber 15, the desired volume of the mixing chamber being accurately positioned by means of the adjusting nut 6, the upstream end 8 then being fixed to the housing by means of the locking nut 7 through the thread 84 and the projection 83; a magnetic stirrer rotor 4 is arranged in the mixing chamber, said rotor comprising a permanent magnet active core and a sheath of thermoplastically processable polymer containing a blade structure; the stator is designed as a bearing stator and a driver stator, with stator disks 52 and stator teeth 5, which are both stators of electric drives and stators of magnetic bearings, it being possible to use the electrical windings 51 of the bearing stator and of the driver stator to generate a rotating magnetic field which, on the one hand, exerts a torque on the rotor causing it to rotate and, on the other hand, exerts a freely adjustable transverse force on the rotor so that its radial position can be actively controlled or modulated; the outlet of the mixing cavity is provided with a filter, the filter assembly comprises filter sieve plates 11 and 16 and a filter membrane 10, and the filter membrane is mainly used for filtering out possible impurities in the solution so as to protect the non-free colloid;
FIG. 3 shows the general form of a rotor with permanent magnets arranged in a distributed pattern around the circumference of an annular rotor, with an outer coating of polymeric material forming an impeller that may be configured to facilitate shear mixing in accordance with the prior art; the center of the impeller is provided with a small hole 41, so that the fluid pressurized by the impeller flows from downstream to upstream, thereby balancing the pressure difference and reducing the axial thrust of the pressure difference on the rotor.
Fig. 4 shows the structure of the mixer housing, the studs 32 on the outside of the housing being used as an aid in positioning the adjusting position of the nut 6; a flat 33 formed on the inside of the housing which, together with the flat 18 on the downstream end 1, serves to assist in the tightening between the nut 2 and the housing thread 31.
Fig. 5 shows the overall appearance of the mixer, without the coated housing being shown on the outside of the stator 5, for the sake of convenience in showing the structure of the stator and the electrical windings on the stator.
In use, the stator part is mounted on the apparatus with the coated housing, the mixer housing being inserted through the stator bore from the lower part of the stator after the mixing chamber volume has been adjusted; the downstream end of the mixer is locked by a nut after being filled with the filtering membrane, and the downstream end of the mixer is directly seated on the stator by utilizing the fact that the outer diameter of the nut is larger than the aperture of the stator, so that the downstream end of the mixer can be conveniently taken down or installed by plugging without an additional fixing device; this vertical mounting also facilitates the venting and gravity drainage of the liquid.
In addition, the smaller stator bore matched to the mixer can reduce air gap reluctance, thereby reducing power loss and improving mixing efficiency.
In practical manufacturing, sensors may also be mounted directly on the stator teeth for detecting the radial position and the rotational speed of the rotor, commonly used sensors such as: a hall sensor, or a magnetoresistive sensor, or also an eddy current sensor, and/or the sensor unit may also be composed of a plurality of sensor arrays.
In operation, batches of different buffers pumped from the pump are allowed to dwell in the mixing chamber for a time period during which the different buffers are sheared and mixed by the high speed rotating impeller to form a uniform solution which is filtered and discharged from the mixer into the downstream gel. Since the magnetic thrust can be adjusted by increasing the current to increase the rotation speed of the rotor, the bearingless motor can provide high-speed stirring, so that the volume of the mixing cavity can be further reduced on the basis of the conventional volume of the mixing cavity calculated according to the residence time, and the system has the advantage of smaller dead volume.
The embodiments in the specification are described in a progressive manner, and the same and similar parts among the embodiments can be referred to each other, and each embodiment focuses on the differences from the other embodiments. In particular, for the method embodiments described later, since they correspond to the system, the description is simple, and for the relevant points, reference may be made to the partial description of the system embodiments.
The above description is only for the specific embodiments of the present application, but the scope of the present application is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present application should be covered within the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (9)
1. An on-line buffer solution dispensing magnetic mixer, comprising:
having a housing (3); the housing having opposite upstream and downstream ends, the upstream end (8) comprising a fluid inlet (81) and a passage (82), and the downstream end (1) comprising a fluid outlet (14) and a passage (13); an upstream end portion (8) is movably fixed in the housing (3) by means of the seal of an O-ring (9), said movable upstream end portion defining the volume of the mixing chamber (15); a magnetic stirrer rotor (4) is arranged in the mixing chamber, the rotor comprising a permanent magnet active core and a sheath of a blade-containing structure made of a thermoplastically processable polymer; the stator (5) is designed as a bearing stator and a driver stator, which are both stators of electric drives and stators of magnetic bearings, and the electrical windings of the bearing stator and the driver stator can be used to generate a rotating magnetic field which, on the one hand, exerts a torque on the rotor causing it to rotate and, on the other hand, exerts a freely adjustable transverse force on the rotor so that its radial position can be actively controlled or modulated; the outlet of the mixing cavity is provided with a filter, and the filter assembly comprises filter sieve plates (11) and (16) and a filter membrane (10).
2. Mixer according to claim 1, wherein the rotor is designed as a ring, with a central through hole connecting the upstream and downstream for balancing the pressure.
3. A mixer according to claim 1, wherein the end surface of the upstream end portion (8) facing the chamber has a domed floor adapted for radial uniform distribution of the fluid in the cavity.
4. A mixer according to claim 1, wherein the end surface of the downstream end portion (1) facing the chamber has a domed floor adapted for radial uniform distribution of the fluid in the cavity.
5. A mixer according to claim 1, wherein the upstream end portion (8) is kept sealed against the movement of the housing (3) by means of O-rings.
6. A mixer according to claim 5, wherein the upstream end (8) is positioned by means of a positioning nut (6) and threads (86) of the housing (3), by locking of a locking nut (7), so as to adjust and fix the volume of the mixing chamber.
7. A mixer according to claim 1, wherein the downstream end (1) and the housing (3) are locked to the housing (3) by means of a fastening nut (2).
8. The mixer according to claim 1, characterized in that the magnetic stirring, wherein the stator (5) and the rotor (4) form a bearingless motor, such that the rotor (4) can be held in the stator (5) by passively acting reluctance forces, the rotor (4) being actively controllable and drivable with respect to three degrees of freedom by means of electric windings (51), the rotor (4) being positioned in the cavity (15) of the housing (3) in a zero-contact drivable and floating manner.
9. The mixer of claim 8, wherein the controllable magnetic levitation design enables the rotor rotating at high speed to avoid rubbing against the inner walls of the narrow mixing chamber to cause adverse effects.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210819300.7A CN115178162A (en) | 2022-07-17 | 2022-07-17 | Online buffer solution preparation magnetic mixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210819300.7A CN115178162A (en) | 2022-07-17 | 2022-07-17 | Online buffer solution preparation magnetic mixer |
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| Publication Number | Publication Date |
|---|---|
| CN115178162A true CN115178162A (en) | 2022-10-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210819300.7A Pending CN115178162A (en) | 2022-07-17 | 2022-07-17 | Online buffer solution preparation magnetic mixer |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130070555A1 (en) * | 2010-05-31 | 2013-03-21 | Ge Healthcare Bio-Sciences Ab | Adjustable volume mixer chamber and method of use |
| US20170302145A1 (en) * | 2016-04-14 | 2017-10-19 | Levitronix Gmbh | Electromagnetic rotary drive and rotational device |
| CN212237108U (en) * | 2020-02-27 | 2020-12-29 | 氢键高科化工技术(天津)有限公司 | Light stabilizer is charge device for sewage treatment |
-
2022
- 2022-07-17 CN CN202210819300.7A patent/CN115178162A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130070555A1 (en) * | 2010-05-31 | 2013-03-21 | Ge Healthcare Bio-Sciences Ab | Adjustable volume mixer chamber and method of use |
| US20170302145A1 (en) * | 2016-04-14 | 2017-10-19 | Levitronix Gmbh | Electromagnetic rotary drive and rotational device |
| CN212237108U (en) * | 2020-02-27 | 2020-12-29 | 氢键高科化工技术(天津)有限公司 | Light stabilizer is charge device for sewage treatment |
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