CN115137920A - Vaccine atomizer, assembling method thereof and mask - Google Patents

Vaccine atomizer, assembling method thereof and mask Download PDF

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Publication number
CN115137920A
CN115137920A CN202210126165.8A CN202210126165A CN115137920A CN 115137920 A CN115137920 A CN 115137920A CN 202210126165 A CN202210126165 A CN 202210126165A CN 115137920 A CN115137920 A CN 115137920A
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vaccine
layer
atomizer
sieve
mesh
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邓巍巍
于博洋
陈丹儿
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Southwest University of Science and Technology
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Southwest University of Science and Technology
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Priority to CN202210126165.8A priority Critical patent/CN115137920A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
    • A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
    • A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D27/00—Details of garments or of their making
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D2400/00—Functions or special features of garments
    • A41D2400/32—Therapeutic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/08—Supports for equipment
    • A61M2209/088—Supports for equipment on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0606—Face

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Textile Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
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Abstract

The invention provides a vaccine atomizer, an assembling method thereof and a mask, wherein the vaccine atomizer comprises an atomizer body provided with a containing cavity, and the containing cavity can contain a vaccine; a piezoelectric ceramic layer disposed on the atomizer body and in contact with the vaccine; and the sieve mesh layer is arranged at the opening of the containing cavity and is in contact with the vaccine. The mesh layer with the cooperation of atomizer body will the bacterin encapsulation is in hold the intracavity, just by laser punching formation sieve mesh on the mesh layer to realize that non-atomizing bacterin is stored hold the intracavity, the bacterin after the atomizing is followed separate out in the sieve mesh. Through the structure, the disposable vaccine atomizer can be obtained, so that large-scale vaccination can be realized at low cost.

Description

Vaccine atomizer, assembling method thereof and mask
Technical Field
The application relates to the technical field of vaccine atomization and inoculation, in particular to a vaccine atomizer, an assembling method thereof and a mask.
Background
Compared with the traditional intramuscular injection vaccination method, the prior art realizes a novel administration mode of vaccine inhalation by atomization, thereby realizing the effects of no needle, no pain, simple use and less dosage.
In the existing aerosol inhalation vaccine technology, vaccines are generally atomized into tiny droplets by an atomizer developed by Aerogen, and then a person to be vaccinated inhales the droplets into the respiratory tract and the lung by breathing, so that mucosal immunity is stimulated, and the immunization by the aerosol inhalation is painless and has higher accessibility. The core technology of the Aerogen atomizer is a palladium alloy vibration grid technology, 1000 precisely formed micropores are distributed on a central orifice plate with the diameter of 5mm, and the vibration is carried out for 128000 times per second, so that liquid drops with the size most favorable for deep lung deposition are formed. However, such nebulizer delivery systems are complex, costly and, since they are not disposable products, they require cleaning and sterilization for repeated use, resulting in a complex application.
Therefore, the prior art is in need of improvement.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a vaccine atomizer, an assembly method thereof and a mask, so as to realize large-scale vaccination with low cost through a disposable vaccine atomizer.
The invention provides a vaccine nebulizer, comprising:
the vaccine atomizer comprises an atomizer body, wherein an accommodating cavity is formed in the atomizer body so as to accommodate a vaccine;
a piezoelectric ceramic layer disposed on the atomizer body and in contact with the vaccine;
the mesh layer, the mesh layer sets up hold the opening part in chamber and with the bacterin contact, the mesh layer with the cooperation of atomizer body will the bacterin encapsulation is in hold the intracavity, just punch by laser on the mesh layer and form the sieve mesh to realize not atomizing bacterin storage is in hold the intracavity, the bacterin after the atomizing is followed separate out in the sieve mesh.
The vaccine atomizer, wherein the diameter of the screen holes on the screen hole layer is 0.5-5 μm.
Vaccine atomizer, wherein, piezoceramics layer sets up the opening part that holds the chamber just the orifice layer sets up piezoceramics layer's central point puts, piezoceramics layer with the orifice layer will vaccine package in hold the intracavity.
Vaccine atomizer, wherein, piezoceramics layer sets up hold the bottom in chamber, piezoceramics layer with the mesh layer sets up the both sides of vaccine, in order to incite somebody to action vaccine encapsulation is in hold the intracavity.
The vaccine atomizer, wherein, the mesh layer is the stainless steel board of processing through laser beam drilling.
The vaccine nebulizer, wherein the vaccine nebulizer further comprises:
the sealing layer is arranged on the sieve layer, one side of the sieve layer is in contact with the vaccine, the other side of the sieve layer is in contact with the sealing layer, and the sealing layer assists in sealing the sieve layer to prevent the vaccine from being lost in the storage process.
The vaccine nebulizer, wherein the vaccine nebulizer further comprises:
and one end of the power supply interface is connected with the piezoelectric ceramic layer, and the other end of the power supply interface is connected with an external power supply, so that the piezoelectric ceramic layer provides electric energy to realize atomization of the vaccine.
Vaccine atomizer, wherein, the mesh layer through medical glue with atomizer body fixed connection to realize vaccine atomizer's integral structure.
A method of assembling a vaccine nebulizer as claimed in any one of the preceding claims, comprising the steps of:
forming a containing cavity on the atomizer body to contain the vaccine;
forming sieve holes on the sieve layer through laser drilling, arranging the sieve layer at an opening of the accommodating cavity, and matching the sieve layer with the atomizer body to seal the accommodating cavity;
injecting the vaccine into the accommodating cavity, packaging the vaccine in the accommodating cavity, and contacting the vaccine with the sieve pore layer and the piezoelectric ceramic layer on the atomizer body to store the vaccine which is not atomized in the accommodating cavity, and separating the atomized vaccine out of the sieve pores.
The utility model provides a mask, wherein, mask includes the mask body, as above arbitrary vaccine atomizer to and external power supply, vaccine atomizer sets up on the mask body and with external power supply electricity is connected, works as the atomized vaccine is appeared after the circular telegram of vaccine atomizer, realizes the inoculation of vaccine.
The invention provides a vaccine atomizer, an assembling method thereof and a mask, wherein the vaccine atomizer comprises an atomizer body provided with a containing cavity, and the containing cavity can contain a vaccine; a piezoelectric ceramic layer disposed on the atomizer body and in contact with the vaccine; and the sieve mesh layer is arranged at the opening of the containing cavity and is in contact with the vaccine. The mesh layer with the cooperation of atomizer body will the bacterin encapsulation is in hold the intracavity, just by laser punching formation sieve mesh on the mesh layer to realize that non-atomizing bacterin is stored hold the intracavity, the bacterin after the atomizing is followed separate out in the sieve mesh. Through the structure, the disposable vaccine atomizer can be obtained, so that large-scale vaccination can be realized at low cost. .
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the description of the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present invention, and it is also possible for those skilled in the art to obtain other drawings based on the drawings without creative efforts.
FIG. 1 is a schematic diagram of a vaccine nebulizer in a vaccine nebulized state according to an embodiment of the invention;
FIG. 2 is a schematic view of a vaccine nebulizer in a sealed state according to an embodiment of the invention;
FIG. 3 is a schematic diagram of a vaccine nebulizer in a vaccine nebulized state according to another embodiment of the invention;
FIG. 4 is a schematic view of a vaccine nebulizer in a sealed state according to another embodiment of the invention;
FIG. 5 is a schematic front view of a mesh layer of the present invention;
fig. 6 is a flow chart of an assembly method of the vaccine nebulizer according to the invention.
Detailed Description
In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that the terms "center", "upper", "lower", "left", "right", "inner", "outer", "vertical", "horizontal", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of the description, but do not indicate or imply that the structures referred to must have a specific orientation or must be constructed in a specific orientation, and should not be construed as limiting the invention.
The invention provides a vaccine atomizer and an assembly method thereof. As shown in fig. 1 and 3, the vaccine nebulizer includes a nebulizer body 100, a piezoelectric ceramic layer 200, and a mesh layer 300. Specifically, an accommodating cavity 110 is arranged on the atomizer body 100, and the accommodating cavity 110 is used for accommodating a vaccine; the piezoelectric ceramic layer 200 is fixed on the atomizer body 100, and the piezoelectric ceramic layer 200 is in contact with the vaccine contained in the containing cavity 110, so that when the piezoelectric ceramic layer 200 is electrified to work, electric energy is converted into mechanical energy, and the vaccine in the containing cavity 110 is atomized; the mesh layer 300 is arranged at the opening of the containing cavity 110 and is in contact with the vaccine contained in the containing cavity 110, so that the mesh layer 300 is matched with the atomizer body 100 to close the containing cavity 110, and the vaccine is packaged in the vaccine atomizer.
Further, the sieve layer 300 is provided with micropores formed by laser drilling as sieve holes, so that it is ensured that the vaccine is encapsulated in the containing cavity 110 in an un-atomized state and does not flow out through the sieve holes, the vaccine is separated out from the containing cavity 110 through the sieve holes after atomization, and the user inhales atomized vaccine droplets to realize vaccination. Alternatively, the mesh layer 300 is a stainless steel plate on which mesh holes having a diameter of 0.5 μm to 5 μm are formed by a laser drilling technique, the mesh holes being arranged at uniform intervals on the stainless steel plate. Optionally, the sieve pores formed by laser drilling on the sieve pore layer 300 are 0.9 μm to ensure that the vaccine is encapsulated in the containing cavity 110 in an un-atomized state and does not flow out through the sieve pores, the vaccine is separated out from the containing cavity 110 through the sieve pores after atomization, a user inhales the atomized vaccine droplets to realize vaccination, and meanwhile, through setting the size of the sieve pores, the atomized droplets with micron scale can be generated, so that the deep place of a respiratory tract can be reached, the dosage of the medicament is less, and mucosal immunity, cellular immunity and humoral immunity can be realized simultaneously.
Alternatively, as shown in fig. 5, the mesh layer 300 is in the shape of a button, and uniformly arranged meshes are formed at the central position of the mesh layer 300 by a laser drilling technique. Alternatively, the mesh layer 300 may be any shape as long as the mesh layer 300 has a shape and size that is matched with the opening of the containing cavity 110, so as to realize the encapsulation of the vaccine in the containing cavity 110, which is not limited herein. Optionally, the mesh layer 300 is fixedly connected with the atomizer body 100 through medical glue to form an integrated structure, so that the cost of producing and manufacturing the vaccine atomizer is reduced, the vaccine atomizer is convenient to use as disposable vaccination equipment, and the vaccine atomizer can be applied to vaccination in a large scale. Alternatively, the medical adhesive is a hot melt pressure sensitive adhesive.
Further, as shown in fig. 1 and fig. 3, the piezoceramic layer 200 is provided with a power interface 210. One end of the power interface 210 is connected to the piezoelectric ceramic layer 200, and the other end of the power interface 210 extends out of the vaccine atomizer so as to be connected to an external power source. The piezoelectric ceramic layer 200 is connected to an external power source through the power interface 210, and works by supplying electric energy through the external power source. The piezoelectric ceramic layer 200 converts electric energy into mechanical energy after being electrified, and the vaccine is atomized after the piezoelectric ceramic layer 200 starts to work by contacting the vaccine in the accommodating cavity 110.
Further, as shown in fig. 2 and 4, the vaccine nebulizer further comprises a sealing layer 400. The sealing layer 400 is arranged on the sieve layer 300, and the sealing layer 400 and the vaccine are respectively located on two opposite sides of the sieve layer 300, namely, one side of the sieve layer 300 is in contact with the vaccine, the other side of the sieve layer 300 is in contact with the sealing layer 400, and the sealing layer 400 assists in sealing the sieve layer 300 so as to prevent the vaccine from being lost in the storage process. After the housing chamber 110 is filled with vaccine, the sealing layer 400 is used to achieve a sealed state of the vaccine nebulizer, the sealing layer 400 assists in sealing the vaccine within the housing chamber 110 of the vaccine nebulizer, thereby preventing loss of the vaccine during storage and transportation. Optionally, the sealing layer 400 is the silica gel material the sealing layer 400 is supplementary to be sealed after the encapsulation of vaccine atomizer the mesh layer 300 to and seal hold the bacterin in the chamber 110, tear when using the sealing layer 400, remove the sealing layer 400 is right the sealing of mesh layer 300, the vaccine atomizer gets into the operating condition of atomizing bacterin. After atomization, the vaccine is separated out through the sieve holes in the sieve hole layer 300, so that the user can realize vaccination through breathing. The sealing layer 400 enables the vaccine nebulizer to be used once, so that the vaccine nebulizer is simple to use and can be applied to vaccination on a large scale.
Further, as shown in fig. 1 and 3, the piezoceramic layer 200 and the mesh layer 300 are provided with different relative positional relationships for different structures.
In one embodiment of the present invention, as shown in fig. 1 and fig. 2, the atomizer body 100 is recessed to form an accommodating chamber 110 with an open top, the piezoceramic layer 200 is disposed at the opening of the accommodating chamber 110, the mesh layer 300 is also disposed at the opening of the accommodating chamber 110, and the piezoceramic layer 200 and the mesh layer 300 are coplanar, and the piezoceramic layer 200 and the mesh layer 300 cooperate with the atomizer body 100 to close the accommodating chamber 110, so as to encapsulate the vaccine in the accommodating chamber 110. Optionally, the mesh layer 300 is disposed in the center of the piezoceramic layer 200, and the mesh layer 300 and the piezoceramic layer 200 are simultaneously in contact with the vaccine contained in the containing cavity 110, and the vaccine is sandwiched between the atomizer body 100 and the piezoceramic layer 200 and the mesh layer 300. When the vaccine nebulizer is in a sealed state, as shown in fig. 2, the sealing layer 400 assists in closing the mesh layer 300, thereby sealing the vaccine within the containing cavity 110 of the vaccine nebulizer; when the vaccine atomizer enters a vaccine atomization state, as shown in fig. 1, the piezoelectric ceramic layer 200 starts to work, the vaccine is atomized by the piezoelectric ceramic layer 200 to form vaccine droplets 500, and the vaccine droplets 500 are separated out from the sieve pores of the sieve pore layer 300, so that a user can inhale the atomized vaccine droplets through breathing, and finally reach alveolar tissues, and mucosal immunity, cellular immunity and humoral immunity are realized simultaneously.
Optionally, the atomizer body 100 is made of medical plastic, the atomizer body 100 and the piezoelectric ceramic layer 200 are adhered to form an integrated structure through medical adhesive, and the mesh layer 300 is adhered to form an integrated structure through medical adhesive and the piezoelectric ceramic layer 200. Optionally, the nebulizer body 100 is recessed inwardly to form a containing cavity 110 with a volume of one vaccine dose, thereby forming a vaccine nebulizer for single use, which can achieve mass vaccination at low cost. Alternatively, the volume of the receiving cavity 110 is 0.5mL.
In another embodiment of the present invention, as shown in fig. 3 and 4, the piezoceramic layer 200 is disposed at the bottom of the containing cavity 110 and contacts with the vaccine packaged in the containing cavity 110, and the piezoceramic layer 200 cooperates with the atomizer body 100 to form the containing cavity 110. Optionally, the atomizer body 100 is disposed in a ring shape, and the accommodating chamber 110 is formed around the piezoelectric ceramic layer 200. The mesh layer 300 is disposed at an opening at the top of the receiving chamber 110 and is in contact with the vaccine packaged in the receiving chamber 110. The atomizer body 100 is in form bearing structure between mesh layer 300 and piezoceramics layer 200, atomizer body 100 piezoceramics layer 200 with mesh layer 300 cooperation is sealed hold chamber 110, and will the bacterin encapsulation is in hold inside the chamber 110. The vaccine is sandwiched between the mesh layer 300 and the piezoceramic layer 200, and when the vaccine nebulizer is in a sealed state, as shown in fig. 4, the sealing layer 400 assists in closing the mesh layer 300, thereby sealing the vaccine within the containing cavity 110 of the vaccine nebulizer; when the vaccine atomizer enters a vaccine atomization state, as shown in fig. 3, when the piezoelectric ceramic layer 200 starts to work, the piezoelectric ceramic layer 200 atomizes the vaccine to form vaccine droplets 500, and the vaccine droplets 500 are separated out from the sieve holes of the sieve hole layer 300, so that a user inhales the atomized vaccine droplets through breathing, and finally, the vaccine droplets reach alveolar tissues, and mucosal immunity, cellular immunity and humoral immunity are realized at the same time.
Optionally, the atomizer body 100 is made of medical plastics, and the atomizer body 100, the mesh layer 300 and the piezoelectric ceramic layer 200 are fixed and adhered through medical glue to form an integrated structure. Optionally, the atomizer body 100, the mesh layer 300 and the piezoelectric ceramic layer 200 cooperate to form a containing cavity 110 with a volume of one vaccine dose, thereby forming a vaccine atomizer for disposable use, which can realize large-scale vaccination at low cost. Alternatively, the volume of the receiving cavity 110 is 0.5mL.
The present invention also provides an assembling method of a vaccine nebulizer, as shown in fig. 6, the assembling method comprising the steps of:
s100, forming a containing cavity on the atomizer body to contain the vaccine;
s200, forming sieve holes on a sieve layer through laser drilling, arranging the sieve layer at an opening of the containing cavity, and matching the sieve layer with the atomizer body to seal the containing cavity;
s300, injecting the vaccine into the containing cavity, packaging the vaccine in the containing cavity, and contacting the vaccine with the sieve pore layer and the piezoelectric ceramic layer on the atomizer body to store the vaccine which is not atomized in the containing cavity and separate the atomized vaccine out of the sieve pores.
Optionally, after the step S300, the assembling method further includes the steps of:
s400, arranging a sealing layer on the other side, opposite to the vaccine, of the sieve pore layer to assist in sealing the containing cavity and prevent the vaccine from being lost in the transportation and storage processes.
Further, the invention also provides a mask, which comprises a mask body, the vaccine atomizer and an external power supply, wherein the vaccine atomizer is arranged on the mask body and is electrically connected with the external power supply, and atomized vaccines are separated out after the vaccine atomizer is electrified to realize vaccination.
Alternatively, the gauze mask can be any gauze mask, like cotton gauze mask, non-woven fabrics gauze mask, macromolecular material gauze mask etc. or disposable medical gauze mask, medical surgery gauze mask, particulate matter protective mask, medical protective mask etc. as long as can fix the bacterin atomizer guarantees that vaccination in-process atomized liquid drop gets into the respiratory track can.
The structure of the vaccine atomizer of the present invention is briefly described below with reference to the following specific examples and the accompanying drawings:
in an embodiment of the present invention, as shown in fig. 1 and fig. 2, an accommodating cavity 110 with an open top is formed by recessing a medical plastic atomizer body 100, a piezoelectric ceramic layer 200 is disposed at the opening of the accommodating cavity 110, and the piezoelectric ceramic layer 200 is fixed and integrated with the atomizer body 100 through medical adhesive. Utilize laser drilling technique to form the micropore that the diameter is 0.5 mu m-5 mu m on stainless steel plate to obtain mesh layer 300, will through medical glue mesh layer 300 with piezoceramics layer 200 is fixed integration sets up, mesh layer 300 embedding piezoceramics layer 200's central point puts, makes mesh layer 300 with piezoceramics layer 200 all with the inner space direct contact who holds chamber 110, piezoceramics layer 200 with mesh layer 300 jointly with atomizer body 100 cooperation realizes sealing hold chamber 110.
After the accommodating cavity 110 is closed, vaccines are injected into the accommodating cavity 110, and through the arrangement of the diameters of the sieve holes on the sieve hole layer 300, when the piezoelectric ceramic layer 200 does not work, namely the vaccines are not atomized, the vaccines are closed in the accommodating cavity 110 and cannot be separated out; when the piezoelectric ceramic layer 200 starts to work, that is, the vaccine is atomized to form vaccine droplets 500, the vaccine droplets 500 are separated out from the sieve pores of the sieve pore layer 300, so that a user inhales the atomized vaccine droplets through breathing, and finally, the vaccine droplets reach alveolar tissues, and mucosal immunity, cellular immunity and humoral immunity are realized simultaneously.
Further, a sealing layer 400 is disposed on the other side of the mesh layer 300 opposite to the vaccine to assist in sealing the containing cavity 110 to achieve a sealed state of the vaccine nebulizer, so as to avoid loss of the vaccine during transportation or storage.
In another embodiment of the present invention, as shown in fig. 3 and 4, an atomizer body 100 is disposed on a piezoceramic layer 200, the atomizer body surrounds to form an accommodating cavity 110, the piezoceramic layer 200 is fixedly integrated with the atomizer body 100 through medical adhesive, the bottom of the accommodating cavity 110 is disposed on the piezoceramic layer 200, and the top of the accommodating cavity 110 is open. The method comprises the steps of forming micropores with the diameter of 0.5-5 microns on a stainless steel plate by utilizing a laser drilling technology to obtain a sieve layer 300, fixedly connecting the sieve layer 300 with the atomizer body 100 through medical glue, and arranging the sieve layer 300 at the opening at the top of the accommodating cavity 110, so that the sieve layer 300 and the piezoelectric ceramic layer 200 are both in direct contact with the inner space of the accommodating cavity 110. The mesh layer 300, the atomizer body 100 and the piezoceramic layer 200 cooperate to close the accommodating cavity 110.
After the accommodating cavity 110 is closed, vaccines are injected into the accommodating cavity 110, and through the arrangement of the diameters of the sieve holes on the sieve hole layer 300, when the piezoelectric ceramic layer 200 does not work, namely the vaccines are not atomized, the vaccines are closed in the accommodating cavity 110 and cannot be separated out; when the piezoelectric ceramic layer 200 starts to work, that is, the vaccine is atomized to form vaccine droplets 500, the vaccine droplets 500 are separated out from the sieve pores of the sieve pore layer 300, so that a user inhales the atomized vaccine droplets through breathing, and finally, the vaccine droplets reach alveolar tissues, and mucosal immunity, cellular immunity and humoral immunity are realized simultaneously.
Further, a sealing layer 400 is disposed on the other side of the mesh layer 300 opposite to the vaccine to assist in sealing the accommodating chamber 110 to achieve a sealed state of the vaccine nebulizer, so as to avoid loss of the vaccine during transportation or storage.
In summary, the invention provides a vaccine atomizer, an assembling method thereof and a mask, wherein the vaccine atomizer comprises an atomizer body provided with a containing cavity, and the containing cavity can contain a vaccine; a piezoelectric ceramic layer disposed on the atomizer body and in contact with the vaccine; and the sieve mesh layer is arranged at the opening of the containing cavity and is in contact with the vaccine. The mesh layer with the cooperation of atomizer body will the bacterin encapsulation is in hold the intracavity, just by laser punching formation sieve mesh on the mesh layer to realize that non-atomizing bacterin is stored hold the intracavity, the bacterin after the atomizing is followed separate out in the sieve mesh. Through the structure, the disposable vaccine atomizer can be obtained, so that large-scale vaccination can be realized at low cost.
All possible combinations of the technical features in the above embodiments may not be described for the sake of brevity, but should be considered as being within the scope of the present disclosure as long as there is no contradiction between the combinations of the technical features.

Claims (10)

1. A vaccine nebulizer, comprising:
the vaccine atomizer comprises an atomizer body, wherein an accommodating cavity is formed in the atomizer body so as to accommodate a vaccine;
a piezoelectric ceramic layer disposed on the atomizer body and in contact with the vaccine;
the mesh layer, the mesh layer sets up hold the opening part in chamber and with the bacterin contact, the mesh layer with the cooperation of atomizer body will the bacterin encapsulation is in hold the intracavity, just by laser punching formation sieve mesh on the mesh layer, in order to realize not atomizing bacterin storage hold the intracavity, the bacterin after the atomizing is followed precipitate in the sieve mesh.
2. The vaccine nebulizer of claim 1, wherein the diameter of the mesh on the mesh layer is 0.5 μm to 5 μm.
3. The vaccine nebulizer of claim 2, wherein the piezoceramic layer is arranged at the opening of the accommodating cavity and the mesh layer is arranged in the center of the piezoceramic layer, and the piezoceramic layer and the mesh layer encapsulate the vaccine in the accommodating cavity.
4. The vaccine nebulizer of claim 2, wherein the piezoceramic layer is disposed at a bottom of the containing cavity, and the piezoceramic layer and the mesh layer are disposed on both sides of the vaccine to encapsulate the vaccine in the containing cavity.
5. Vaccine nebulizer according to claim 3 or 4, characterized in that the mesh layer is a laser-drilled stainless steel plate.
6. The vaccine nebulizer of claim 5, further comprising:
the sealing layer is arranged on the sieve layer, one side of the sieve layer is in contact with the vaccine, the other side of the sieve layer is in contact with the sealing layer, and the sealing layer assists in sealing the sieve layer to prevent the vaccine from being lost in the storage process.
7. The vaccine nebulizer of claim 5, further comprising:
and one end of the power supply interface is connected with the piezoelectric ceramic layer, and the other end of the power supply interface is connected with an external power supply, so that the piezoelectric ceramic layer provides electric energy to realize atomization of the vaccine.
8. The vaccine atomizer according to claim 5, wherein the mesh layer is fixedly connected with the atomizer body by medical glue to realize an integrated structure of the vaccine atomizer.
9. A method of assembling a vaccine nebulizer according to any one of claims 1 to 8, comprising the steps of:
forming a containing cavity on the atomizer body to contain the vaccine;
forming sieve holes on the sieve layer through laser drilling, arranging the sieve layer at an opening of the accommodating cavity, and matching the sieve layer with the atomizer body to seal the accommodating cavity;
injecting the vaccine into the accommodating cavity, encapsulating the vaccine in the accommodating cavity, and contacting the vaccine with the sieve pore layer and the piezoelectric ceramic layer on the atomizer body to store the non-atomized vaccine in the accommodating cavity and separate the atomized vaccine out of the sieve pore.
10. A mask, characterized in that, the mask includes the mask body, according to any one of claim 1-8 vaccine atomizer, and external power supply, the vaccine atomizer sets up on the mask body and with external power supply electricity is connected, separates out atomizing vaccine after the bacterin atomizer circular telegram, realizes the inoculation of bacterin.
CN202210126165.8A 2022-02-10 2022-02-10 Vaccine atomizer, assembling method thereof and mask Pending CN115137920A (en)

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CN111420188A (en) * 2020-04-02 2020-07-17 重庆医科大学 High-efficient vibration atomizer
CN113121215A (en) * 2021-03-26 2021-07-16 西安电子科技大学 Lead-free piezoelectric ceramic, atomizing sheet and preparation method
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JPH0780369A (en) * 1993-09-16 1995-03-28 Omron Corp Mesh member for ultrasonic type inhaler and its production
CN101648041A (en) * 2009-09-02 2010-02-17 王成 Medical micropore atomization medicine absorber
JP2013141532A (en) * 2012-01-11 2013-07-22 Dainippon Printing Co Ltd Liquid cartridge for spray device, liquid cartridge package, and method of manufacturing spray device and liquid cartridge for spray device
CN104220176A (en) * 2012-04-23 2014-12-17 空气芳香研究股份有限公司 Atomiser system
JP2013252261A (en) * 2012-06-06 2013-12-19 Dainippon Printing Co Ltd Liquid cartridge for spray device, liquid cartridge package, spray device, and container with mesh for spray device
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CN205031672U (en) * 2015-08-19 2016-02-17 北京谊安医疗系统股份有限公司 Medicinal atomizing device of breathing machine gas circuit load
CN206355406U (en) * 2016-09-22 2017-07-28 声海电子（深圳）有限公司 A kind of ultrasonic atomizatio structure and the ultrasonic atomizatio equipment using the structure
CN107376064A (en) * 2017-07-31 2017-11-24 南京鱼跃软件技术有限公司 A kind of atomising device and method of automatic identification difference mesh strip Frequency point
CN108903064A (en) * 2018-09-06 2018-11-30 华健 A kind of high frequency ultrasound atomization structure
CN209984729U (en) * 2019-03-19 2020-01-24 天津赛德生物制药有限公司 Nuclear pore membrane assembly for net type atomizer
CN210992329U (en) * 2019-05-21 2020-07-14 广州畅呼医疗器械有限公司 Piezoelectric ceramic atomizing sheet structure
CN111420188A (en) * 2020-04-02 2020-07-17 重庆医科大学 High-efficient vibration atomizer
CN113121215A (en) * 2021-03-26 2021-07-16 西安电子科技大学 Lead-free piezoelectric ceramic, atomizing sheet and preparation method
CN215024229U (en) * 2021-04-06 2021-12-07 天津怡和嘉业医疗科技有限公司 Atomizing barrel, atomizing shell and atomizer

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