CN115137847B - 共轭碳碘聚合物用于制备胃肠道壁形态检查试剂的应用 - Google Patents

共轭碳碘聚合物用于制备胃肠道壁形态检查试剂的应用 Download PDF

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CN115137847B
CN115137847B CN202210711129.8A CN202210711129A CN115137847B CN 115137847 B CN115137847 B CN 115137847B CN 202210711129 A CN202210711129 A CN 202210711129A CN 115137847 B CN115137847 B CN 115137847B
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罗亮
殷明明
刘小明
孟凡玲
雷子乔
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Huazhong University of Science and Technology
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Abstract

本发明涉及一种共轭碳碘聚合物用于制备胃肠道壁形态检查试剂的应用，属于成像技术领域。本发明提供了一种含有聚二乙炔主链，但只有碘原子取代基的共轭聚合物，含碘量高，具有超高X射线吸收效率；纳米纤维结构可以很好地与胃肠道壁结合，从而基于共轭碳碘聚合物进行CT成像即可实现对胃肠道壁的形态检查。相比传统胃镜或者肠镜检查而言，本发明中的检查方法快速便捷，可实现整个胃肠道的检查，并且避免了病人额外的痛楚。

Description

共轭碳碘聚合物用于制备胃肠道壁形态检查试剂的应用
技术领域
本发明属于成像技术领域，更具体地，涉及一种共轭碳碘聚合物用于制备胃肠道壁形态检查试剂的应用。
背景技术
消化道疾病是一组极其多样化，涵盖了涉及食道、胃、小肠、大肠和直肠的多种疾病。例如，克罗恩病和溃疡性结肠炎作为慢性疾病给日常生活带来了诸多不便，而且发病率不断增加。快速安全的检测方法对于早期诊断和及时管理至关重要。过去内窥镜检查和透视是一线诊断测试手段。然而，这些技术仅限于评估管腔和粘膜表面，无法评估肠壁的粘膜下层。内窥镜检查是侵入性的，特别是如果随着时间的推移需要多次随访研究，这是次优的选择。在许多情况下，CT或X射线成像被用作标准的GI成像方法。用于胃肠道成像的对比剂可以增强对比度以区分异常病变和正常结构。对比剂用于吸收外部X射线，以减少探测器上的曝光量，从而为成像提供对比度。目前临床最常用的胃肠道成像的对比剂——钡餐BaSO4悬浊液很容易产生明显沉聚而非旋涂下胃肠道壁表面。这样一方面会导致消化道轮廓旋涂显示不均匀，只能增加硫酸钡用量来实现消化道的充盈灌注成像。而硫酸钡本身排出时间长，对需要进行检测的消化道病人来说更是一个负担。另一方面，硫酸钡沉聚之后会产生明显的CT条纹状伪影，影响CT成像质量和后续诊断。综合来说临床上胃肠道壁形态检查急需克服内窥镜检查和钡餐CT检查固有缺陷，寻找更加方便快捷的胃肠道壁形态检查新方法。
发明内容
本发明解决了现有技术中胃肠道壁形态检查操作复杂，对病人造成极大痛楚，对胃肠道壁难以清楚显示的技术问题。本发明提供了一种含有聚二乙炔(PDA)主链，但只有碘原子取代基的共轭聚合物，含碘量高，具有超高X射线吸收效率；纳米纤维结构可以很好地与胃肠道壁结合。
根据本发明的目的，提供了一种共轭碳碘聚合物用于制备胃肠道壁形态检查试剂的应用。
优选地，所述共轭碳碘聚合物的结构式包括式1所示的结构：
Figure BDA0003706925910000021
优选地，所述共轭碳碘聚合物的结构式如式Ⅰ或式Ⅱ所示：
Figure BDA0003706925910000022
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Figure BDA0003706925910000031
优选地，所述共轭碳碘聚合物通过吸附在胃肠道壁上CT成像实现对胃肠道壁的形态检查。
总体而言，通过本发明所构思的以上技术方案与现有技术相比，主要具备以下的技术优点：
(1)本发明提供了一种含有聚二乙炔主链，但只有碘原子取代基的共轭聚合物，含碘量高，具有超高X射线吸收效率；纳米纤维结构可以很好地与胃肠道壁结合。
(2)本发明共轭碳碘聚合物为纳米纤维结构，可以很好地与胃肠道壁上的粘膜相结合。
(3)本发明共轭碳碘聚合物用于胃肠道壁形态检查，检查方法快速便捷，可实现整个胃肠道的检查，并且避免了病人额外的痛楚。
(4)本发明共轭碳碘聚合物生物相容性良好，不会引发其他副反应。
(5)本发明共轭碳碘聚合物蓝黑色，利于肉眼分辨；共轭碳碘聚合物含碘量高达84％，具有很强的CT成像能力，CT信号极强，利于CT成像。
附图说明
图1为本发明提出的共轭碳碘聚合物与硫酸钡CT对比图；
图2为本发明提出的大鼠口服共轭碳碘聚合物后CT三维成像图；
图3为本发明提出的大鼠口服同等浓度硫酸钡后CT三维成像图；
图4为本发明提出的大鼠口服高浓度硫酸钡后CT三维成像图；
图5为本发明提出的大鼠口服共轭碳碘聚合物后CT整体成像图；
图6为本发明提出的大鼠灌肠共轭碳碘聚合物后CT整体成像图。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。此外，下面所描述的本发明各个实施方式中所涉及到的技术特征只要彼此之间未构成冲突就可以相互组合。
本发明中的共轭碳碘聚合物的制备可参见公开号为CN114149569A的发明专利。
实施例1
测试不同浓度的式Ⅰ所示的共轭碳碘聚合物(PIDA)的CT信号，并与对应浓度的钡餐(BaSO4)对比(图1)。结果表明，式Ⅰ所示的共轭碳碘聚合物的CT信号强度与其浓度呈现线性正相关，于此同时，共轭碳碘聚合物的CT信号强度也比明显强于同等浓度条件下钡餐的CT信号强度。
实施例2
给大鼠口服5mg mL-1的式Ⅰ所示的共轭碳碘聚合物之后，CT的三维成像图可以很明显的观察到胃肠道的三维结构，对应不同时间点的胃壁横截面图表明在2小时之后即可显示完整的胃壁图像(图2)。以同等浓度的硫酸钡作为对照，大鼠口服后对应的CT三维成像图显示胃肠道壁三维结构不完整，并且界面图显示硫酸钡存在于空腔中，并未与胃肠道壁很好的结合(图3)。进一步增加口服的硫酸钡浓度为100mg mL-1，结果表明CT成像结果伪影过于严重，失去了胃肠道壁形态检查的功能性(图4)。
实施例3
给大鼠口服5mg mL-1式Ⅰ所示的共轭碳碘聚合物之后，大鼠的CT整体成像图表明可以高质量的显示胃和小肠的整体结构(图5)；给大鼠灌肠5mg mL-1的共轭碳碘聚合物之后，大鼠的CT整体成像图表明可以高质量的显示大肠的整体结果(图6)。这表明共轭碳碘聚合物可以快速便捷实现整个胃肠道的检查，并且避免了病人额外的痛楚。
本领域的技术人员容易理解，以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。

Claims (2)

1.一种共轭碳碘聚合物用于制备胃肠道壁形态检查试剂的应用，其特征在于，所述共轭碳碘聚合物为纳米纤维结构，所述共轭碳碘聚合物的结构式如式Ⅰ所示：
Figure FDA0004191905890000011
2.如权利要求1所述的应用，其特征在于，所述共轭碳碘聚合物通过吸附在胃肠道壁上CT成像实现对胃肠道壁的形态检查。
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