CN115120788A - Medical hydrophilic coating solution and coating method thereof - Google Patents
Medical hydrophilic coating solution and coating method thereof Download PDFInfo
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- CN115120788A CN115120788A CN202210533409.4A CN202210533409A CN115120788A CN 115120788 A CN115120788 A CN 115120788A CN 202210533409 A CN202210533409 A CN 202210533409A CN 115120788 A CN115120788 A CN 115120788A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/04—Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
Abstract
The application relates to the technical field of hydrophilic coatings, in particular to a medical hydrophilic coating solution and a coating method thereof. The medical hydrophilic coating solution consists of a primer composition and a finish composition; the primer composition comprises the following components in parts by weight: 10-25 parts of water-based bonding base material, 0.2-0.3 part of first photoinitiator, 2-5 parts of cross-linking agent and 75-95 parts of first solvent; the finish paint composition comprises the following components in parts by weight: 8-12 parts of hydrophilic polyurethane, 5-10 parts of polyvinylpyrrolidone, 0-2 parts of silane coupling agent, 0-5 parts of nano silicon dioxide, 0.1-0.3 part of second photoinitiator and 75-95 parts of second solvent. This application uses through the complex formulation of priming paint composition and finish paint composition, when having ensured the lubricated, moist effect of coating, is showing to improve its adhesive force, is difficult for taking place to peel off with ox horn expander.
Description
Technical Field
The application relates to the technical field of hydrophilic coatings, in particular to a medical hydrophilic coating solution and a coating method thereof.
Background
The medical hydrophilic coating is a technology for modifying the surface of a medical instrument, meets the medical standard requirements, has good biocompatibility, and has the characteristics of reducing the contact friction between the medical instrument and a human body, being beneficial to reducing the operation difficulty of a doctor, reducing the pain of a patient and the like, so that the medical hydrophilic coating is researched and specially used for modifying the surface of a ox horn dilator.
The medical hydrophilic coating solution in the related art discloses a hydrophilic coating solution containing hydrophilic high molecular polymers such as polyvinylpyrrolidone and polyatomic alcohol, and the hydrophilic coating solution has good toughness in a dry state, can be uniformly adhered to the surface of a ox horn dilator, is colorless and transparent, and is not easy to observe by naked eyes;
in a wet state, the coating can be quickly activated by water to hydrate and form colorless and transparent hydrogel, and the hydrogel coating is highly lubricating and can bear repeated friction, so that the ox horn dilator surface is endowed with excellent lubricating property and wettability.
Although the medical hydrophilic coating solution can meet the basic application requirements of people and has excellent lubricating and wetting properties, the general cohesiveness and the adhesive force are poor, and the cured coating is easy to peel off under the action of internal stress or external force, so that the lubricating and wetting effects are greatly reduced.
Disclosure of Invention
In order to ensure the lubricating and wetting effects of the coating and improve the adhesive force of the coating at the same time, so that the coating is not easy to peel off, the application provides a medical hydrophilic coating solution and a coating method thereof.
In a first aspect, the present application provides a medical hydrophilic coating solution, which adopts the following technical scheme:
a medical hydrophilic coating solution is composed of a primer composition and a finish composition;
the primer composition comprises the following components in parts by weight: 10-25 parts of water-based bonding base material, 0.2-0.3 part of first photoinitiator, 2-5 parts of cross-linking agent and 75-95 parts of first solvent;
the water-based bonding base material is prepared by blending and modifying saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide imide;
the finish paint composition comprises the following components in parts by weight: 8-12 parts of hydrophilic polyurethane, 5-10 parts of polyvinylpyrrolidone, 0-2 parts of silane coupling agent, 0-5 parts of nano silicon dioxide, 0.1-0.3 part of second photoinitiator and 75-95 parts of second solvent.
By adopting the technical scheme, after the medical hydrophilic coating solution obtained by mixing the primer composition and the finish composition is respectively coated on the surface of the ox horn dilator, the adhesive force of the medical hydrophilic coating solution can be improved by the primer composition, so that the coating structure is not easy to fall off, meanwhile, the finish composition can endow the medical hydrophilic coating solution with excellent lubricating and wetting effects, the compatibility of the primer composition and the finish composition is good, the coating structure formed by curing the primer composition and the finish composition is stable, and the high performance can be kept for a long time.
The reason for this analysis may be:
the water-based bonding base material formed by blending the saturated polyester resin, the unsaturated acrylic resin, the polyamide wax and the polyamide imide has a synergistic effect among the components, a compact composite reticular structure can be formed by bonding double bonds and polar groups, the reticular structures are stacked layer by layer and are mutually crosslinked, the viscosity and the adhesion performance of the coating are obviously enhanced, and in addition, the composite reticular structure can be further crosslinked and reacted with the hydrophilic polyurethane under the action of a crosslinking agent, so that the binding property and the stability of the primer composition and the finish paint composition are enhanced.
Preferably, the amount ratio of the saturated polyester resin, the unsaturated acrylic resin, the polyamide wax and the polyamide imide is 1 (0.8-1.5) to (0.2-0.3) to (0.3-0.5).
By adopting the technical scheme, the aqueous bonding base material formed by blending the saturated polyester resin, the unsaturated acrylic resin, the polyamide wax and the polyamide-imide in the proportion has a better synergistic effect among the components, and a cross-linked and formed composite net structure is more compact and complex, so that the primer composition is endowed with excellent viscosity and adhesion performance.
Preferably, the first photoinitiator and the second photoinitiator are respectively selected from one or more of 1-hydroxycyclohexyl phenyl ketone, diphenylethanone and 2, 4-dihydroxy benzophenone.
By adopting the technical scheme, the components and the photoinitiator prepared according to the proportion can effectively absorb the wavelength of an ultraviolet region and generate a large amount of free radicals and cations, so that the crosslinking and curing of the primer composition and the finish composition are promoted.
Preferably, the cross-linking agent is one or more of ethylene glycol dimethacrylate, polyethylene glycol diacrylate and 1, 4-butanediol diacrylate.
By adopting the technical scheme, the cross-linking agent prepared from the components and the proportion can effectively provide a diradical and an active group, and form a bridge bond with a polymer molecular chain and a double bond, thereby being beneficial to forming a compact and complex three-dimensional cross-linking network structure.
Preferably, the first solvent is one or more of ethanol, glycerol and ethyl acetate; the second solvent is composed of two or more of ethanol, isopropanol, ethyl acetate and water.
Preferably, the primer composition consists of the following components in parts by weight: 8-12 parts of hydrophilic polyurethane, 5-10 parts of polyvinylpyrrolidone, 1-2 parts of silane coupling agent, 2-5 parts of nano silicon dioxide, 0.1-0.3 part of second photoinitiator and 75-95 parts of second solvent.
By adopting the technical scheme, the finish paint composition with the components and the proportion can further enhance the mechanical property under the action of the nano silicon dioxide and the silane coupling agent, and can also obviously reduce the surface energy of the coating surface after being compounded with the hydrophilic polyurethane and the polyvinylpyrrolidone, thereby achieving better lubricating and wetting effects.
In a second aspect, the present application provides a coating method of a medical hydrophilic coating solution, which adopts the following technical scheme: a coating method of medical hydrophilic coating solution comprises the following coating steps:
s1, firstly, soaking the ox horn expander to be coated in the primer composition, after the primer composition is coated, lifting the ox horn expander to be coated, and carrying out primary irradiation curing under an ultraviolet lamp to obtain the ox horn expander coated with the bottom layer;
and S2, soaking the ox horn dilator coated with the bottom layer into the finish paint composition, lifting the ox horn dilator coated with the bottom layer after the finish paint composition is coated, and performing secondary irradiation curing under an ultraviolet lamp to obtain the ox horn dilator coated with the hydrophilic coating.
Preferably, the specific coating steps are as follows:
s1, firstly, soaking the ox horn expander to be coated in the primer composition for 30-60S, after the primer composition is coated, lifting the ox horn expander to be coated at a constant speed of 0.5-1.0cm/S, and primarily irradiating and curing for 60-90S under a 1200W ultraviolet lamp to obtain the ox horn expander coated with the bottom layer;
and S2, soaking the ox horn expander coated with the bottom layer in the finish paint composition for 20-30S, after the finish paint composition is coated, taking out the ox horn expander coated with the bottom layer at a constant speed of 0.5-1.0cm/S, and performing secondary irradiation curing for 90-180S under an ultraviolet lamp of 600W to finish coating, thereby obtaining the ox horn expander coated with the hydrophilic coating.
By adopting the technical scheme, the medical hydrophilic coating solution sequentially coated on the surface of the ox horn dilator by the coating method can improve the integral adhesive force while ensuring the surface lubricating and wetting effects, the operating conditions are easy to control, the energy consumption is low, the performance of the obtained product is stable and uniform, and the method is suitable for industrialized processing and production.
In summary, the present application has the following beneficial effects:
1. according to the application, the primer composition and the finish composition are compounded, so that the adhesive force is improved, the coating structure is not easy to fall off, the surface of the primer composition has excellent lubricating and wetting effects, the primer composition and the finish composition are good in compatibility, the coating structure formed by curing the primer composition and the finish composition is stable, and high performance can be maintained for a long time;
2. by doping the nano silicon dioxide and the silane coupling agent, the mechanical property of the coating structure is enhanced, and the surface energy of the coating surface can be obviously reduced after the nano silicon dioxide and the silane coupling agent are compounded with the hydrophilic polyurethane and the polyvinylpyrrolidone, so that better lubricating and wetting effects are achieved;
3. the medical hydrophilic coating solution sequentially coated on the surface of the ox horn dilator by the coating method can improve the overall adhesive force of the coating structure while ensuring the surface lubricating and wetting effects, has low energy consumption and is suitable for industrialized processing and production.
Detailed Description
The present application will be described in further detail with reference to examples.
The starting materials used in the examples of the present application are commercially available, except as specifically noted below:
hydrophilic polyurethane, designation WanSpongeFPT, purchased from tsu yuan tairun chemical ltd;
polyvinylpyrrolidone, CAS registry number 9003-39-8;
saturated polyester resin, brand polyester resin 930, model CW-Zn-002, purchased from Shanghai Kaiyn chemical Co., Ltd;
polyamide wax, DuPont, tradename, purchased from Kyon chemical Co., Ltd;
polyamideimide, trade name 4301, available from hong plastication limited, available in Dongguan;
unsaturated acrylic resin, model ALK150-2, purchased from Yuxuan practice Co., Ltd, Dongguan city;
polyethylene glycol diacrylate, CAS 26570-48-9;
silane coupling agent, model KH-550, brand Dewar/DOUWAR, purchased from Dewar chemical (Shanghai) Inc.;
the nano silicon dioxide has the average particle size of 20nm and the specific surface area of 200m2/g, and is purchased from Nanjing Baoke New Material Co.
Preparation example
Preparation example 1
A medical hydrophilic coating solution is prepared from a primer composition and a finish composition, wherein the components and parts by weight of the primer composition and the finish composition are shown in Table 1;
wherein the water-based bonding base material consists of saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide-imide according to the weight ratio of 1:0.5:0.1: 0.2;
the first photoinitiator and the second photoinitiator are 1-hydroxycyclohexyl phenyl ketone;
the cross-linking agent is ethylene glycol dimethacrylate;
the silane coupling agent is KH-550;
the first solvent is ethanol; the second solvent consists of ethanol and ethyl acetate according to the weight ratio of 1: 0.5.
The medical hydrophilic coating solution is prepared by the following preparation steps: and (3) mixing the components in the primer composition and the finish composition at 2500r/min for 30min respectively, and stirring the components into uniform slurry to obtain the medical hydrophilic coating solution.
Preparation examples 2 to 6
A hydrophilic coating solution for medical use, which is different from preparation example 1 in that the components of an aqueous binder base and their respective weights are shown in table 1.
TABLE 1 PREPARATION EXAMPLES 1-6 Components and weights (kg) of hydrophilic coating solutions for TCM
Preparation example 7
A medical hydrophilic coating solution was prepared in the same manner as in preparation example 1, except that the water-based adhesive base material consisted of a saturated polyester resin, an unsaturated acrylic resin, a polyamide wax and a polyamideimide in a weight ratio of 1:0.8:0.2: 0.3.
Preparation example 8
A medical hydrophilic coating solution was prepared in the same manner as in preparation example 1, except that the water-based adhesive base material consisted of a saturated polyester resin, an unsaturated acrylic resin, a polyamide wax and a polyamideimide in a weight ratio of 1:1.2:0.2: 0.4.
Preparation example 9
A medical hydrophilic coating solution was prepared in the same manner as in preparation example 1, except that the water-based adhesive base material consisted of a saturated polyester resin, an unsaturated acrylic resin, a polyamide wax and a polyamideimide in a weight ratio of 1:1.5:0.3: 0.5.
Preparation example 10
A hydrophilic coating solution for medical use was prepared in the same manner as in preparation example 1 except that the water-bondable base material consisted of a saturated polyester resin, an unsaturated acrylic resin, a polyamide wax and a polyamideimide in a weight ratio of 1:2:0.5: 1.
Preparation example 11
A medical hydrophilic coating solution, which was the same as in preparation example 1 except that the first photoinitiator and the second photoinitiator were diphenylethanone.
Preparation example 12
A medical hydrophilic coating solution, which was the same as in preparation example 1, except that the first photoinitiator was 1-hydroxycyclohexyl phenyl ketone and the second photoinitiator was diphenylethanone.
Preparation example 13
A medical hydrophilic coating solution was the same as in preparation example 1 except that the first photoinitiator was 1-hydroxycyclohexyl phenyl ketone and 2, 4-dihydroxybenzophenone at a weight ratio of 1:0.3, and the second photoinitiator was diphenylethanone.
Preparation example 14
A hydrophilic coating solution for medical use was the same as in preparation example 1 except that the crosslinking agent was polyethylene glycol diacrylate.
Preparation example 15
A hydrophilic coating solution for medical use was the same as in preparation example 1 except that the crosslinking agent was 1, 4-butanediol diacrylate.
Preparation example 16
A medical hydrophilic coating solution was the same as in preparation example 1 except that the crosslinking agent was composed of ethylene glycol dimethacrylate and 1, 4-butylene glycol diacrylate at a weight ratio of 1: 2.
Preparation example 17
A medical hydrophilic coating solution, which is ethyl acetate except a first solvent; the second solvent was the same as in preparation example 1 except that it was composed of ethanol and water in a weight ratio of 1: 0.1.
Preparation example 18
A medical hydrophilic coating solution was the same as in preparation example 1 except that the first solvent and the second solvent were each composed of ethanol and ethyl acetate at a weight ratio of 1: 0.3.
Performance test
The ox horn expanders coated with the medical hydrophilic coating in the examples and the comparative examples are selected as detection objects, the adhesion and the hydrophilic wettability of each group are respectively tested, and the detection steps are as follows, and reference is made to GB-T5210-.
1) Adhesion detection
According to the regulation of GB/T5210-2006, a test column with the diameter of 20mm is adopted, an upper test column and a lower test column are coaxially butted with a test plate for testing, three groups of medical hydrophilic coating solutions are arranged in parallel in each group, and the average value of the test results is recorded.
2) Hydrophilic wettability (coating contact angle)
And detecting according to the specification of DB 44/T1232-2013, wherein three groups are arranged in parallel in each group, after the pure water is dripped on the surface of the ox horn dilator, recording the three-phase contact points of liquid, solid and gas phases and the internal included angle of a base line and a tangent line, and taking the average value to record the contact angle of the coating so as to represent the hydrophilic wettability of the coating.
Examples
Example 1
A method for coating a medical hydrophilic coating solution, which uses the medical hydrophilic coating solution prepared in preparation example 1, comprises the following coating steps:
s1, firstly, soaking the ox horn expander to be coated in the primer composition for 30S, after the primer composition is coated, lifting the ox horn expander to be coated at a constant speed of 1.0cm/S, and irradiating and curing the ox horn expander at the next stage of an ultraviolet lamp of 1200W for 60S to obtain the ox horn expander coated with the bottom layer;
and S2, soaking the ox horn expander coated with the bottom layer in the finish paint composition for 20S, after the finish paint composition is coated, taking out the ox horn expander coated with the bottom layer at a constant speed of 1.0cm/S, and performing secondary irradiation and curing for 90S under an ultraviolet lamp of 600W to complete coating, thereby obtaining the ox horn expander coated with the hydrophilic coating.
Examples 2 to 6
The difference between the method for coating the medical hydrophilic coating solution and the embodiment 1 is that the medical hydrophilic coating solution is used in different conditions, and the specific corresponding relationship is shown in the table below.
Table: EXAMPLES 2-6 comparative tables of use of the hydrophilic coating solutions for TCM
| Group of | Medical hydrophilic coating solution |
| Example 2 | Prepared from preparation example 2 |
| Example 3 | Prepared from preparation example 3 |
| Example 4 | Prepared from preparation example 4 |
| Example 5 | Prepared from preparation example 5 |
| Example 6 | Prepared from preparation example 6 |
Comparative example 1
The difference between the method for coating the medical hydrophilic coating solution and the embodiment 1 is that the medical hydrophilic coating solution consists of the following components in parts by weight: 8 parts of waterborne polyurethane, 5 parts of polyvinyl pyrrolidine, 0.1 part of photoinitiator and 90 parts of solvent;
wherein the photoinitiator is 1-hydroxycyclohexyl phenyl ketone, and the solvent is ethanol and ethyl acetate according to the weight ratio of 1: 0.5.
The bovine horn dilators coated with the medical hydrophilic coating solution of examples 1 to 6 and comparative example 1 were extracted, and the adhesion and hydrophilic wettability were measured according to the above measurement procedures and measurement standards, and the average values of the test results were recorded in the following table.
As can be seen from the above table, the medical hydrophilic coating solutions prepared in examples 1-6 have stronger adhesive force up to 5.6-6.6MPa, which is improved by 33-55% compared with the traditional Chinese medical hydrophilic coating solution in comparative example 1; in addition, the coating has excellent hydrophilic wettability, and the contact angle of the coating is only 3-5 degrees;
therefore, after the medical hydrophilic coating solution with the components is coated on the surface of the ox horn dilator, the adhesive force of the medical hydrophilic coating solution can be improved through the primer composition, excellent lubricating and wetting effects can be endowed through the finish composition, the compatibility of the primer composition and the finish composition is good, the coating structure formed by curing the primer composition and the finish composition is stable, and high performance can be kept for a long time.
In particular, the medical hydrophilic coating solution prepared in the examples 3 to 4 has strong adhesive force up to 6.5 to 6.6 MPa; and the contact angle of the coating is only 3 degrees, which is 2 degrees lower than that of the coating of the embodiment 1-2 without adding the nano silicon dioxide and the silane coupling agent;
the components and the proportion of the medical hydrophilic coating solution are seen to have optimal compounding effect, and when the amount of the water-based binding base material or the cross-linking agent is continuously increased, the performance of the coating is not increased as expected, and the reason for analyzing the performance of the coating is probably because the cross-linking state between the components is saturated, see application examples 5-6.
In summary, the reason for this analysis may be that, due to the synergistic effect among the components of the aqueous binding binder, a dense composite network structure may be formed by bonding of double bonds and polar groups, and the network structures are stacked one on top of another and cross-linked with each other, thereby significantly enhancing the viscosity and adhesion property of the coating, and in addition, the composite network structure may further cross-link with the hydrophilic polyurethane under the action of the cross-linking agent, thereby enhancing the binding property and stability of the primer composition and the topcoat composition.
Examples 7 to 10
The difference between the method for coating the medical hydrophilic coating solution and the embodiment 1 is that the medical hydrophilic coating solution is used in different conditions, and the specific corresponding relationship is shown in the table below.
Table: EXAMPLES 7-10 comparative tables of use of the hydrophilic coating solutions for TCM
| Group of | Medical hydrophilic coating solution |
| Example 7 | Prepared from preparation example 7 |
| Example 8 | Prepared from preparation example 8 |
| Example 9 | Prepared from preparation example 9 |
| Example 10 | Prepared from preparation example 10 |
Comparative example 2
A method for applying a hydrophilic coating solution for medical use, which is different from example 1 in that an aqueous binder base material is composed of a saturated polyester resin and an unsaturated acrylic resin at a weight ratio of 1: 1.5.
Comparative example 3
A medical hydrophilic coating solution coating method is different from that of example 1 in that a water-based bonding base material consists of unsaturated acrylic resin, polyamide wax and polyamide imide according to a weight ratio of 1:0.2: 0.3.
The bovine horn dilators coated with the medical hydrophilic coating solution in the above examples 7 to 10 and comparative examples 2 to 3 were extracted, and the adhesion and hydrophilic wettability were measured according to the above measurement procedures and measurement standards, and the test results were averaged and recorded in the following table.
As can be seen from the table above, the medical hydrophilic coating solutions prepared in examples 1 and 7-10 have strong adhesive force up to 5.6-6.5MPa, which is improved by 17-22% compared with comparative examples 2-3; in addition, the coating has excellent hydrophilic wettability, and the contact angle of the coating is only 5 degrees;
therefore, the water-based bonding base material formed by blending the saturated polyester resin, the unsaturated acrylic resin, the polyamide wax and the polyamide imide according to the proportion has better synergistic effect among the components, the cross-linked and formed composite net structure is more compact and complex, and the primer composition is endowed with excellent viscosity and adhesion property, and the adhesion property is reduced after a certain component is lacked, as shown in comparative examples 2-3.
In particular, the medical hydrophilic coating solutions prepared in examples 7 to 9 had strong adhesion up to 6.3 to 6.5 MPa; and the contact angle of the coating is only 5 degrees, so that the water-based bonding base material has better compounding effect when the water-based bonding base material consists of saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide-imide according to the dosage ratio of 1 (0.8-1.5) to (0.2-0.3) to (0.3-0.5).
Examples 11 to 13
The difference between the method for coating the medical hydrophilic coating solution and the embodiment 1 is that the medical hydrophilic coating solution is used in different conditions, and the specific corresponding relationship is shown in the table below.
Table (b): EXAMPLES 11-13 comparative tables of use of hydrophilic coating solutions for TCM
| Group of | Medical hydrophilic coating solution |
| Example 11 | Prepared from preparation example 11 |
| Example 12 | Prepared from preparation example 12 |
| Example 13 | Prepared from preparation example 13 |
The bovine horn dilators coated with the medical hydrophilic coating solution of examples 11 to 13 were extracted, and the adhesion and hydrophilic wettability were measured according to the above measurement procedures and measurement standards, and the average values of the test results were recorded in the following table.
As can be seen from the above table, the medical hydrophilic coating solutions prepared in examples 1, 11-13 have strong adhesion, up to 5.5-5.8 MPa; in addition, the coating has excellent hydrophilic wettability, and the contact angle of the coating is only 5 degrees;
the components and the photoinitiator prepared according to the proportion can effectively absorb the wavelength of an ultraviolet region and generate a large amount of free radicals and cations, so that the crosslinking and curing of the primer composition and the finish composition are promoted, the influence on the actual wetting property and the adhesive force of the coating is weak, and the adhesive force is improved in a small range only during compound use.
Examples 14 to 16
The difference between the method for coating the medical hydrophilic coating solution and the embodiment 1 is that the medical hydrophilic coating solution is used in different conditions, and the specific corresponding relationship is shown in the table below.
Table (b): EXAMPLES 14-16 comparative tables of use of the hydrophilic coating solutions for TCM
| Group of | Medical hydrophilic coating solution |
| Example 14 | Prepared from preparation example 14 |
| Example 15 | Prepared from preparation example 15 |
| Example 16 | Prepared from preparation example 16 |
The bovine horn dilators coated with the medical hydrophilic coating solution of examples 14 to 16 were extracted, and the adhesion and hydrophilic wettability were measured according to the above measurement procedures and measurement standards, and the test results were averaged and recorded in the following table.
As can be seen from the above table, the medical hydrophilic coating solutions prepared in examples 1 and 14-16 have strong adhesive force up to 5.5-6.0 MPa; in addition, the coating has excellent hydrophilic wettability, and the contact angle of the coating is only 5 degrees;
therefore, the cross-linking agent with the components and the proportion can effectively provide the diradical and the active group, and form a bridge bond with a polymer molecular chain and a double bond, thereby being beneficial to forming a compact and complex three-dimensional cross-linked network structure, having influence on the actual adhesive force performance and viscosity of the coating, and improving the adhesive force by 7-9 percent when the cross-linking agent is compounded by ethylene glycol dimethacrylate and 1, 4-butanediol diacrylate.
Examples 17 to 18
A method for coating a medical hydrophilic coating solution, which is different from the method in example 1 in that the medical hydrophilic coating solution is used in different conditions, and the specific correspondence relationship is shown in the following table.
Table: EXAMPLES 17-18 comparative tables of use of the hydrophilic coating solutions for TCM
| Group of | Medical hydrophilic coating solution |
| Example 17 | Prepared from preparation example 17 |
| Example 18 | Prepared from preparation 18 |
The bovine horn dilators coated with the medical hydrophilic coating solution of examples 17 to 18 were extracted, and the adhesion and hydrophilic wettability were measured according to the above measurement procedures and measurement standards, and the average values of the test results were recorded in the following table.
As can be seen from the above table, the medical hydrophilic coating solutions prepared in examples 1 and 17-18 have strong adhesive force up to 5.6-5.7 MPa; in addition, the coating has excellent hydrophilic wettability, and the contact angle of the coating is only 5 degrees;
therefore, the components and the solvent in the proportion can effectively ensure the compounding effect of each component, the selection and compounding of the components basically have no influence on the performance of the coating, and the coating is beneficial to actual production and is convenient for cost regulation and quality management.
The specific embodiments are only for explaining the present application and are not limiting to the present application, and those skilled in the art can make modifications to the embodiments without inventive contribution as required after reading the present specification, but all the embodiments are protected by patent law within the scope of the claims of the present application.
Claims (8)
1. A medical hydrophilic coating solution is characterized by consisting of a primer composition and a finish composition;
the primer composition comprises the following components in parts by weight: 10-25 parts of water-based bonding base material, 0.2-0.3 part of first photoinitiator, 2-5 parts of cross-linking agent and 75-95 parts of first solvent;
the water-based bonding base material is prepared by blending and modifying saturated polyester resin, unsaturated acrylic resin, polyamide wax and polyamide-imide;
the finish paint composition comprises the following components in parts by weight: 8-12 parts of hydrophilic polyurethane, 5-10 parts of polyvinylpyrrolidone, 0-2 parts of silane coupling agent, 0-5 parts of nano silicon dioxide, 0.1-0.3 part of second photoinitiator and 75-95 parts of second solvent.
2. The medical hydrophilic coating solution as set forth in claim 1, wherein the saturated polyester resin, the unsaturated acrylic resin, the polyamide wax and the polyamideimide are used in a ratio of 1 (0.8-1.5): 0.2-0.3): 0.3-0.5.
3. The medical hydrophilic coating solution according to claim 1, wherein the first and second photoinitiators are each selected from one or more of 1-hydroxycyclohexyl phenyl ketone, diphenylethanone, 2, 4-dihydroxybenzophenone.
4. The medical hydrophilic coating solution according to claim 1, wherein the cross-linking agent is one or more of ethylene glycol dimethacrylate, polyethylene glycol diacrylate, 1, 4-butylene glycol diacrylate.
5. The medical hydrophilic coating solution according to claim 1, wherein the first solvent is one or more of ethanol, glycerol, ethyl acetate; the second solvent is composed of two or more of ethanol, isopropanol, ethyl acetate and water.
6. The medical hydrophilic coating solution according to claim 1, wherein the top coat composition consists of the following components in parts by weight: 8-12 parts of hydrophilic polyurethane, 5-10 parts of polyvinylpyrrolidone, 1-2 parts of silane coupling agent, 2-5 parts of nano silicon dioxide, 0.1-0.3 part of second photoinitiator and 75-95 parts of second solvent.
7. The method for applying the hydrophilic coating solution for medical use according to any one of claims 1 to 6, comprising the steps of:
s1, firstly, soaking the ox horn expander to be coated in the primer composition, after the primer composition is coated, pulling the ox horn expander to be coated, and irradiating and curing the ox horn expander under an ultraviolet lamp for the first stage to obtain the ox horn expander coated with the bottom layer;
and S2, soaking the ox horn dilator coated with the bottom layer into the finish paint composition, lifting the ox horn dilator coated with the bottom layer after the finish paint composition is coated, and performing secondary irradiation curing under an ultraviolet lamp to obtain the ox horn dilator coated with the hydrophilic coating.
8. The coating method of the medical hydrophilic coating solution according to claim 7, characterized in that the specific coating steps are as follows:
s1, firstly, soaking the ox horn expander to be coated in the primer composition for 30-60S, after the primer composition is coated, lifting the ox horn expander to be coated at a constant speed of 0.5-1.0cm/S, and irradiating and curing the ox horn expander at the first stage under a 1200W ultraviolet lamp for 60-90S to obtain the ox horn expander coated with the bottom layer;
and S2, soaking the ox horn expander coated with the bottom layer in the finish paint composition for 20-30S, after the finish paint composition is coated, taking out the ox horn expander coated with the bottom layer at a constant speed of 0.5-1.0cm/S, and performing secondary irradiation curing for 90-180S under an ultraviolet lamp of 600W to finish coating, thereby obtaining the ox horn expander coated with the hydrophilic coating.
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