CN115119838A - Long-acting mosquito repellent liquid and preparation method thereof - Google Patents
Long-acting mosquito repellent liquid and preparation method thereof Download PDFInfo
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- CN115119838A CN115119838A CN202210884649.9A CN202210884649A CN115119838A CN 115119838 A CN115119838 A CN 115119838A CN 202210884649 A CN202210884649 A CN 202210884649A CN 115119838 A CN115119838 A CN 115119838A
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- 239000000077 insect repellent Substances 0.000 title claims abstract description 109
- 239000007788 liquid Substances 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title claims description 17
- 239000000463 material Substances 0.000 claims abstract description 50
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 48
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 26
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 26
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 25
- 108010010803 Gelatin Proteins 0.000 claims abstract description 23
- 229920000159 gelatin Polymers 0.000 claims abstract description 23
- 239000008273 gelatin Substances 0.000 claims abstract description 23
- 235000019322 gelatine Nutrition 0.000 claims abstract description 23
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 23
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 239000012621 metal-organic framework Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 230000000694 effects Effects 0.000 claims abstract description 14
- 238000002156 mixing Methods 0.000 claims description 19
- 239000000341 volatile oil Substances 0.000 claims description 19
- 235000014633 carbohydrates Nutrition 0.000 claims description 17
- 239000007864 aqueous solution Substances 0.000 claims description 12
- 239000000839 emulsion Substances 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 8
- 241000196324 Embryophyta Species 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- 230000002572 peristaltic effect Effects 0.000 claims description 6
- 229920000136 polysorbate Polymers 0.000 claims description 6
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 claims description 5
- 229960001673 diethyltoluamide Drugs 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 229920001661 Chitosan Polymers 0.000 claims description 3
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- 239000000205 acacia gum Substances 0.000 claims description 3
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- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 4
- 238000004945 emulsification Methods 0.000 description 4
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- 235000006679 Mentha X verticillata Nutrition 0.000 description 3
- 235000002899 Mentha suaveolens Nutrition 0.000 description 3
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- 238000013268 sustained release Methods 0.000 description 3
- 239000012730 sustained-release form Substances 0.000 description 3
- 244000215068 Acacia senegal Species 0.000 description 2
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- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 description 1
- 235000019737 Animal fat Nutrition 0.000 description 1
- 235000003097 Artemisia absinthium Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 241000144210 Culex pipiens pallens Species 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
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- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 239000010632 citronella oil Substances 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
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- 239000001941 cymbopogon citratus dc and cymbopogon flexuosus oil Substances 0.000 description 1
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- 239000010419 fine particle Substances 0.000 description 1
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- 230000006872 improvement Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
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- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
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- 229920005615 natural polymer Polymers 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
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- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/44—Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P17/00—Pest repellants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Botany (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a long-acting mosquito repellent liquid which comprises the following raw materials in parts by weight: 1-3 parts of carbohydrate containing carboxyl, 0.2-1 part of gelatin, 1-2 parts of acetic acid, 5-25 parts of mosquito repellent material, 0.5-2 parts of emulsifier, 0.05-0.3 part of MOFs antibacterial material and 100 parts of pure water. The invention has the beneficial effects that: the long-acting mosquito repellent liquid disclosed by the invention takes carbohydrate containing carboxyl and gelatin as raw materials to form a wall material, so that the wall material wraps a mosquito repellent material, the utilization rate of a mosquito repellent medicine is improved, the toxic and side effects are reduced, the water solubility, the dispersibility and the stability of mosquito repellent components are obviously improved, the volatilization amount is reduced, and the mosquito repellent time is prolonged under the condition of the same usage amount of the mosquito repellent material.
Description
Technical Field
The invention belongs to the technical field of mosquito repellents, and particularly relates to a long-acting mosquito repellent liquid and a preparation method thereof.
Background
The effective chemical components in the existing common mosquito repellent liquid are deet or deet, the dosage is recommended to be below 30%, the maximum mosquito repelling time is 8 hours, the mosquito repelling effect cannot be obviously improved by increasing the content, and the toxicity of the mosquito repellent liquid can be increased. Common plant essential oils with mosquito repelling activity comprise essential oils such as citronella oil, eucalyptus oil, lavender oil, peppermint oil, clove oil, cinnamon oil, camphor tree oil, wormwood oil, lemongrass oil and the like, and are high in safety to human bodies, but the mosquito repelling duration can only reach 4 hours at most. The national sanitation repellent registration class B standards are: no mosquito bite exists within 4 h; the A-level standard is: no mosquito bite is caused within 6 h.
The microcapsule technology is a technology of forming fine particles having a semipermeable or sealed capsule membrane by wrapping dispersed solid, liquid, or even gaseous substances with a natural or synthetic polymer material. After microencapsulation, the microcapsule can change the properties of color, shape, mass, volume, solubility, reactivity, heat resistance, storability and the like of the substance, can store the core material in a fine state and realize the slow release control. The capsule with the particle size of 1-1000nm is called nano capsule, and is a novel material with nano size in the microcapsule. The microcapsule technology is applied to the mosquito repellent to prolong the mosquito repellent time of the mosquito repellent.
At present, all reported microcapsules containing mosquito repelling components are micron-sized, and the effect of demulsification and sustained release is eliminated as soon as water is dried, for example, CN 106137780B-a microcapsule containing mosquito repelling ester, mosquito repelling water and a preparation method thereof, disclose a microcapsule sustained-release mosquito repelling water, the longest mosquito repelling time for culex pipiens pallens can reach 15h, but the mosquito repelling time for culex pipiens is reduced to 12h, the mosquito repelling time needs to be further improved by a nano microcapsule technology, and the mosquito repelling effect for different types of mosquitoes needs to be improved by mixing different mosquito repelling agents.
Disclosure of Invention
The invention aims to provide the long-acting mosquito repellent liquid which has no toxic or side effect, is safe and non-irritant, has an antibacterial effect and is long in mosquito repelling time.
In order to achieve the purpose, the invention adopts the following technical scheme:
the long-acting mosquito repellent liquid comprises the following raw materials in parts by weight: 1-3 parts of carbohydrate containing carboxyl, 0.2-1 part of gelatin, 1-2 parts of acetic acid, 5-25 parts of mosquito repellent material, 0.5-2 parts of emulsifier, 0.05-0.3 part of MOFs antibacterial material and 100 parts of pure water.
The long-acting mosquito repellent liquid is a preferable embodiment and comprises the following raw materials in parts by weight: 2 parts of carbohydrate containing carboxyl, 0.7 part of gelatin, 1.5 parts of acetic acid, 15 parts of mosquito repellent material, 1 part of emulsifier, 0.15 part of MOFs antibacterial material and 100 parts of pure water.
Preferably, the carbohydrate containing carboxyl groups is starch, chitosan, carboxymethyl cellulose or gum arabic.
Preferably, the mosquito repellent material is deet or deet and plant essential oil with mosquito repellent activity, and the weight ratio of the deet or deet to the plant essential oil with mosquito repellent activity in the mosquito repellent material is 8-10: 1-2. The plant essential oil with mosquito repellent activity is one or more of citronella essential oil, mint essential oil, folium artemisiae argyi essential oil, schizonepeta essential oil and eucalyptus oil.
Preferably, the emulsifier is composed of the following raw materials in parts by weight: tween 803-5 parts and span 805-7 parts.
Tween 80 is a nonionic surfactant, has remarkable resistance to electrolyte, strong hydrophilicity, and good emulsification effect on vegetable oil, mineral oil, animal fat, etc.
Span 80 is a nonionic surfactant, and is an excellent water-in-oil or oil-in-water surfactant.
In a second aspect of the application, a preparation method of the long-acting mosquito repellent liquid is provided, and the preparation method comprises the following steps:
(1) mixing carboxyl-containing saccharide and gelatin, heating to dissolve, and adjusting pH of the mixed solution to 4-5 with acetic acid to obtain component A;
(2) adding an emulsifier into the mosquito repellent material, and uniformly mixing to obtain a component B;
(3) dripping the component B into the component A, homogenizing at 45-80 deg.C, stirring, and reacting for 30-60min to obtain emulsion;
(4) preparing the MOFs antibacterial material into an aqueous solution with the concentration of 3-6%, adding the emulsion into the aqueous solution, and uniformly mixing to obtain the long-acting mosquito repellent liquid.
The carbohydrate containing carboxyl is compounded with gelatin, and the negative charge of the carbohydrate containing carboxyl and the positive charge of the gelatin are neutralized to form a wall material. Because the isoelectric point of the gelatin is 4.5, the pH value of the gelatin is adjusted to be 4-5 by adopting acetic acid, the agglomeration rate of the carboxyl-containing saccharide and the gelatin after compounding can be improved, and core materials dispersed in a solution can be coated to form the microcapsule more easily.
If the pH value is increased, the positive charge is reduced, and the coagulation rate is reduced; if the pH is reduced, a large amount of aggregates are generated, so that the viscosity of the system is increased, and the generated high microcapsules are easy to adhere to each other.
The emulsifier adopted by the application is a composite emulsifier of Tween 80 and span 80, and a steric hindrance effect can be formed between the Tween 80 and the span 80, so that the emulsification is facilitated and the stability of the emulsification is improved. The emulsifier can reduce the aggregation speed of oil drops, ensure that the size of the formed microcapsule is between 100 and 800nm, and the addition of the Tween 80 is beneficial to the reduction of the particle size of the nanocapsule.
The reaction temperature of the component B and the component A is 45-80 ℃, the formation of the capsule is facilitated by increasing the reaction temperature, but the hydrogen bond acting force can be destroyed by overhigh temperature, and the stable capsule is not facilitated to be formed. The temperature of 45 ℃ is the temperature required by the dissolution of the gelatin, and under the condition, the electrostatic interaction is increased to 60 ℃ and reaches the maximum, so that a stable capsule structure can be formed, and the reaction temperature designed by the application is 45-80 ℃.
In the preparation method of the long-acting mosquito repellent liquid, as a preferred embodiment, in the step (1), the heating and dissolving temperature is 55-65 ℃.
As a preferred embodiment, in the step (3), the component B is added into the component A through a peristaltic pump with the rotation speed of 100-200 rpm.
As a preferable embodiment, in the step (3), the homogenizing speed is 10000-.
The emulsification frequency has obvious influence on the particle size of the microcapsule, and the particle size of the microcapsule can be kept below 1 micron only by ensuring the homogenization rate of 10000r/min at least, and is the best at 14000 r/min. Mechanical stirring is assisted to ensure that the materials are completely mixed.
The beneficial effects of the invention are as follows: the long-acting mosquito repellent liquid disclosed by the invention takes carbohydrate containing carboxyl and gelatin as raw materials to form a wall material, wraps the mosquito repellent material, improves the utilization rate of the mosquito repellent medicine, reduces toxic and side effects, obviously improves the water solubility, dispersibility and stability of the mosquito repellent component, reduces the volatilization amount, and prolongs the mosquito repellent time under the condition of the same usage amount of the mosquito repellent material.
The microcapsule of the invention is a nano microcapsule with the size of 100-800nm, has the characteristics of small size, large specific surface area and decoration, can improve the utilization rate of mosquito repellent medicaments, reduce toxic and side effects and the like, and can obviously improve the water solubility, dispersibility, stability and slow release of mosquito repellent components. And the mosquito repelling effect on different types of mosquitoes is improved by compounding a plurality of nano mosquito repelling microcapsules.
The long-acting mosquito repellent liquid is prepared by adding MOFs antibacterial materials, so that the antibacterial effect is ensured, the stable sustained-release property of the mosquito repellent liquid is increased, and the long-acting mosquito repellent liquid is safe, free of stimulation and mild in smell.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Example 1
The long-acting mosquito repellent liquid disclosed by the embodiment 1 comprises the following raw materials in parts by weight: 1 part by weight of carbohydrate containing carboxyl, 0.2 part by weight of gelatin, 1 part by weight of acetic acid, 5 parts by weight of mosquito repellent material, 1.0 part by weight of emulsifier, 0.15 part by weight of MOFs antibacterial material and pure water which is supplemented to 100 parts by weight;
the carbohydrate containing carboxyl groups described in this example was starch;
the mosquito repellent material in the embodiment is anophelifuge ester and citronella essential oil; and the weight ratio of the anophelifuge to the citronella essential oil is 10: 2
The emulsifier in the embodiment is prepared from the following raw materials in parts by weight: tween 804 and span 806;
the preparation method of the long-acting mosquito repellent liquid in the embodiment 1 comprises the following steps:
(1) mixing saccharide containing carboxyl and gelatin, heating at 55 deg.C to dissolve, and adjusting pH of the mixed solution to 4 with acetic acid to obtain component A;
(2) adding an emulsifier into the mosquito repellent material, and uniformly mixing to obtain a component B;
(3) dropwise adding the component B into the component A (specifically adding the component B into the component A through a peristaltic pump with the rotation speed of 100 rpm), homogenizing at the temperature of 50 ℃ at the speed of 10000r/min, and mechanically stirring at the speed of 2000r/min for 30min to obtain an emulsion;
(4) preparing the MOFs antibacterial material into a 3% aqueous solution, adding the emulsion into the aqueous solution, and uniformly mixing to obtain the long-acting mosquito repellent.
Example 2
The long-acting mosquito repellent liquid disclosed by the embodiment 2 comprises the following raw materials in parts by weight: 2 parts of carbohydrate containing carboxyl, 0.5 part of gelatin, 1.5 parts of acetic acid, 10 parts of mosquito repellent material, 0.6 part of emulsifier, 0.10 part of MOFs antibacterial material and pure water which are supplemented to 100 parts by weight;
the carbohydrate containing carboxyl groups described in this example was gum arabic;
the mosquito repellent material in the embodiment is anophelifuge and eucalyptus oil; and the weight ratio of the anophelifuge to the eucalyptus oil is 10: 1;
the emulsifier in the embodiment is composed of the following raw materials in parts by weight: tween 804 and span 807;
the preparation method of the long-acting mosquito repellent liquid in the embodiment 2 comprises the following steps:
(1) mixing carboxyl-containing saccharide and gelatin, heating at 60 deg.C to dissolve, and regulating pH of the mixed solution to 4 with acetic acid to obtain component A;
(2) adding an emulsifier into the mosquito repellent material, and uniformly mixing to obtain a component B;
(3) dropwise adding the component B into the component A (specifically adding the component B into the component A through a peristaltic pump with the rotating speed of 120 rpm), homogenizing at the temperature of 50 ℃ at the speed of 12000r/min, and processing for 40min with mechanical stirring at the speed of 1200r/min to obtain an emulsion;
(4) preparing the MOFs antibacterial material into a 4% aqueous solution, adding the emulsion into the aqueous solution, and uniformly mixing to obtain the long-acting mosquito repellent.
Example 3
The long-acting mosquito repellent liquid disclosed by the embodiment 3 comprises the following raw materials in parts by weight: 2 parts of carbohydrate containing carboxyl, 0.5 part of gelatin, 1.5 parts of acetic acid, 15 parts of mosquito repellent material, 1.2 parts of emulsifier, 0.15 part of MOFs antibacterial material and pure water which are supplemented to 100 parts by weight;
the carbohydrate containing carboxyl groups described in this example was chitosan;
the mosquito-repellent material in the embodiment is a mixture of deet, citronella essential oil and schizonepeta essential oil; and the weight ratio of the deet to the citronella essential oil to the schizonepeta essential oil is 12: 2: 1.
the emulsifier in the embodiment is composed of the following raw materials in parts by weight: tween 803 and span 805;
the preparation method of the long-acting mosquito repellent liquid in the embodiment 3 comprises the following steps:
(1) mixing saccharide containing carboxyl and gelatin, heating at 60 deg.C to dissolve, and adjusting pH of the mixed solution to 4 with acetic acid to obtain component A;
(2) adding an emulsifier into the mosquito repellent material, and uniformly mixing to obtain a component B;
(3) dropwise adding the component B into the component A (specifically, adding the component B into the component A through a peristaltic pump with the rotation speed of 150 rpm), homogenizing at the temperature of 60 ℃ at the speed of 15000r/min, and processing for 45min with mechanical stirring at the speed of 1500r/min to obtain an emulsion;
(4) preparing the MOFs antibacterial material into an aqueous solution with the concentration of 5%, adding the emulsion into the aqueous solution, and uniformly mixing to obtain the long-acting mosquito repellent.
Example 4
The long-acting mosquito repellent liquid comprises the following raw materials in parts by weight: 3 parts of carbohydrate containing carboxyl, 1 part of gelatin, 2 parts of acetic acid, 25 parts of mosquito repellent material, 2 parts of emulsifier, 0.3 part of MOFs antibacterial material and 100 parts of pure water;
the carbohydrate containing carboxyl groups described in this example is methylcellulose;
in the embodiment, the mosquito repellent materials are diethyltoluamide and mint essential oil; and the weight ratio of the deet to the mint essential oil is 15: 2.
the emulsifier in the embodiment is prepared from the following raw materials in parts by weight: tween 805 and span 807;
the preparation method of the long-acting mosquito repellent liquid in the embodiment 4 comprises the following steps:
(1) mixing carboxyl-containing saccharide and gelatin, heating at 65 deg.C to dissolve, and adjusting pH of the mixed solution to 5 with acetic acid to obtain component A;
(2) adding an emulsifier into the mosquito repellent material, and uniformly mixing to obtain a component B;
(3) dropwise adding the component B into the component A (specifically adding the component B into the component A through a peristaltic pump with the rotation speed of 200 rpm), homogenizing at 80 deg.C at 20000r/min, and mechanically stirring at 2000r/min for 60min to obtain emulsion;
(4) preparing the MOFs antibacterial material into a 6% aqueous solution, adding the emulsion into the aqueous solution, and uniformly mixing to obtain the long-acting mosquito repellent.
Comparative example 1
The long-acting mosquito repellent liquid in the comparative example 1 is different from the long-acting mosquito repellent liquid in the example 1 in that:
the emulsifier of the long-acting mosquito repellent liquid in the comparative example 1 is span 80, and the other raw materials and the preparation method are the same as those of the long-acting mosquito repellent liquid in the example 1.
Comparative example 2
The long-acting mosquito repellent liquid in the comparative example 2 is different from the long-acting mosquito repellent liquid in the example 2 in that:
comparative example 2 the long-acting mosquito repellent liquid described in example 2 was prepared by dropping the component B into the component a, but the stirring was not uniform, and the remaining operations were the same as in example 2.
Comparative example 3
The long-acting mosquito repellent liquid in the comparative example 3 is different from the long-acting mosquito repellent liquid in the example 3 in that:
comparative example 3 the long-acting mosquito repellent liquid contains mosquito repellent ester, and the other raw materials and preparation method are the same as those in example 3.
Comparative example 4
The long-acting mosquito repellent liquid described in comparative example 4 is different from the long-acting mosquito repellent liquid described in example 4 in that:
in the preparation process of the long-acting mosquito repellent liquid in the comparative example 4, the component B is added into the component A, and the mixture is homogenized, stirred and mixed to react to obtain the long-acting mosquito repellent liquid, and the long-acting mosquito repellent liquid is not compounded with MOFs antibacterial materials.
The long-acting mosquito repellent liquid has the following mosquito repellent effect research:
comparative example 5: the test result of the effective time of the commercial mosquito repellent amine/mosquito repellent ester product dissolved by the organic solvent and the mosquito repellent product of ICRT (International Consumer research and Experimental organization) is as follows: the mosquito repellent of 25 percent deet has the mosquito repelling time of 5.25 hours for Egyptian mosquitoes and the mosquito repelling time of 5.5 hours for Culex fatigues; the mosquito repellent of 25% ester has a duration of 3.13 hours for Egyptian mosquito and a duration of 2.75 hours for Culex fatigues mosquito.
Comparative example 6: the common microcapsule mosquito repellent liquid (the preparation method refers to CN106137780B), has the mosquito repelling time of 12 hours for Aedes albopictus and 13.5 hours for Culex fatigues.
The long-acting mosquito repellent liquid has the following mosquito repellent effect research:
the above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (9)
1. The long-acting mosquito repellent liquid is characterized by comprising the following raw materials in parts by weight: 1-3 parts of carbohydrate containing carboxyl, 0.2-1 part of gelatin, 1-2 parts of acetic acid, 5-25 parts of mosquito repellent material, 0.5-2 parts of emulsifier, 0.05-0.3 part of MOFs antibacterial material and 100 parts of pure water.
2. The long-acting mosquito repellent liquid according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 2 parts of carbohydrate containing carboxyl, 0.7 part of gelatin, 1.5 parts of acetic acid, 15 parts of mosquito repellent material, 1 part of emulsifier, 0.15 part of MOFs antibacterial material and 100 parts of pure water.
3. The long-acting mosquito repellent liquid according to claim 1, wherein the carbohydrate containing carboxyl is starch, chitosan, methylcellulose or acacia gum.
4. The long-acting mosquito repellent liquid according to claim 1, wherein the mosquito repellent material is diethyltoluamide or diethyltoluamide and plant essential oil with mosquito repellent activity, and the weight ratio of the diethyltoluamide or the diethyltoluamide to the plant essential oil with mosquito repellent activity in the mosquito repellent material is 8-10: 1-2.
5. The long-acting mosquito repellent liquid according to claim 1, wherein the emulsifier is composed of the following raw materials in parts by weight: tween 803-5 parts and span 805-7 parts.
6. A method for preparing the long-acting mosquito repellent liquid as claimed in any one of claims 1 to 5, which is characterized by comprising the following steps:
(1) mixing carboxyl-containing saccharide and gelatin, heating to dissolve, and adjusting pH of the mixed solution to 4-5 with acetic acid to obtain component A;
(2) adding an emulsifier into the mosquito repellent material, and uniformly mixing to obtain a component B;
(3) dripping the component B into the component A, homogenizing at 45-80 deg.C, stirring, and reacting for 30-60min to obtain emulsion;
(4) preparing the MOFs antibacterial material into an aqueous solution with the concentration of 3-6%, adding the emulsion into the aqueous solution, and uniformly mixing to obtain the long-acting mosquito repellent.
7. The preparation method of the long-acting mosquito repellent liquid according to claim 6, wherein in the step (1), the heating and dissolving temperature is 55-65 ℃.
8. The preparation method of the long-acting mosquito repellent liquid as claimed in claim 6, wherein in the step (3), the component B is added into the component A through a peristaltic pump at the rotation speed of 100-200 rpm.
9. The method for preparing long-acting mosquito repellent according to claim 6, wherein in the step (3), the homogenizing speed is 10000-.
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Application publication date: 20220930 |