CN115105738B - Small transducer for shallow subcutaneous transdermal drug delivery and manufacturing method thereof - Google Patents
Small transducer for shallow subcutaneous transdermal drug delivery and manufacturing method thereof Download PDFInfo
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- CN115105738B CN115105738B CN202210550607.1A CN202210550607A CN115105738B CN 115105738 B CN115105738 B CN 115105738B CN 202210550607 A CN202210550607 A CN 202210550607A CN 115105738 B CN115105738 B CN 115105738B
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- 238000007920 subcutaneous administration Methods 0.000 title claims abstract description 32
- 238000013271 transdermal drug delivery Methods 0.000 title claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 239000000919 ceramic Substances 0.000 claims abstract description 68
- 229910052751 metal Inorganic materials 0.000 claims abstract description 44
- 239000002184 metal Substances 0.000 claims abstract description 44
- 239000003822 epoxy resin Substances 0.000 claims abstract description 36
- 229920000647 polyepoxide Polymers 0.000 claims abstract description 36
- 238000000034 method Methods 0.000 claims abstract description 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 11
- 229910052709 silver Inorganic materials 0.000 claims description 11
- 239000004332 silver Substances 0.000 claims description 11
- 230000037317 transdermal delivery Effects 0.000 claims description 11
- 229910000838 Al alloy Inorganic materials 0.000 claims description 8
- 238000003466 welding Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 7
- 238000005498 polishing Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 230000006378 damage Effects 0.000 abstract description 5
- 238000009210 therapy by ultrasound Methods 0.000 abstract description 2
- 230000003044 adaptive effect Effects 0.000 abstract 1
- 238000009826 distribution Methods 0.000 description 5
- 230000005779 cell damage Effects 0.000 description 3
- 208000037887 cell injury Diseases 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000001453 impedance spectrum Methods 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 239000004593 Epoxy Substances 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000009211 ultrasonic lithotripsy Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Abstract
The invention provides a small transducer for shallow subcutaneous transdermal drug delivery and a manufacturing method thereof, belonging to the technical field of ultrasonic treatment. Solves the problem that the existing transducer causes damage to cells in deep subcutaneous places in the transdermal drug delivery process. The surface electrode is connected and conducted with the metal shell through epoxy resin, a layer of surface matching layer is paved on the upper surface of the surface piezoelectric ceramic, the surface matching layer is bonded with the piezoelectric ceramic through epoxy resin, the surface matching layer is adaptive to the shape of the surface piezoelectric ceramic, and a wire is welded on the lower surface of the surface piezoelectric ceramic and the inner wall of the metal shell respectively. The invention is suitable for transdermal administration.
Description
Technical Field
The invention belongs to the technical field of ultrasonic treatment, and particularly relates to a small transducer for transdermal drug delivery under shallow skin and a manufacturing method thereof.
Background
The combination of ultrasonic technology and medical technology has been a hot spot in recent years, and the typical application of ultrasonic surgical knives, B-ultrasonic, ultrasonic acupuncture probes, ultrasonic lithotripsy and the like. Unlike electromagnetic wave technology such as X-ray and nuclear magnetic resonance, ultrasonic waves are mechanical waves in nature, can be attenuated rapidly in the propagation process in a human body, and low-intensity ultrasonic waves cannot cause any influence on the human body. In addition, studies have shown that ultrasound is effective in promoting absorption of drugs by the human body, and thus, combining ultrasound with transdermal delivery is now a popular direction.
In the prior art for transdermal drug delivery, the distribution of the ultrasonic field is mostly not considered in the design of the transducer part, so that damage is inevitably caused to cells deep under the skin during the transdermal drug delivery process, and therefore, a brand new transducer is required to be designed for shallow subcutaneous transdermal drug delivery.
Disclosure of Invention
Therefore, the invention aims to provide a small transducer for shallow subcutaneous transdermal drug delivery and a manufacturing method thereof, so as to solve the problem that the existing transducer causes damage to cells in deep subcutaneous places in the transdermal drug delivery process.
In order to achieve the above purpose, the technical scheme of the invention is realized as follows:
the utility model provides a small-size transducer that can be used to shallow subcutaneous transdermal drug delivery, includes curved surface matching layer, curved surface piezoceramics piece and shell, and the shape of curved surface piezoceramics piece is concave spherical crown shape, curved surface piezoceramics piece sets up in the metal shell, and the concave surface of curved surface piezoceramics piece is upwards, and the convex surface is down, and is fixed through epoxy bonding between curved surface piezoceramics piece and the metal shell, and curved surface piezoceramics piece upper surface electrode is connected with the metal shell with quick-drying silver thick liquid and is switched on, lays one deck curved surface matching layer at curved surface piezoceramics's upper surface, and bonds with epoxy between curved surface matching layer and the piezoceramics, curved surface matching layer suits with curved surface piezoceramics shape, welds a wire on curved surface piezoceramics piece's lower surface and metal shell's inner wall respectively, and two wires are connected with the signal source.
Further, the curved surface matching layer is made of a mixture of epoxy resin and tungsten powder, has acoustic impedance of 7.25MRayl and thickness of 4.785 mm.
Furthermore, the cross sections of the curved piezoelectric ceramic piece and the curved matching layer are spherical crown shapes.
Further, the thickness of the curved piezoelectric ceramic piece is 2mm, wherein the height of the spherical crown is 2mm, and the diameter of the spherical crown is 20 mm.
Further, the thickness of the curved surface matching layer is one quarter wavelength of the working frequency of the transducer, wherein the height of the spherical crown is 2mm, and the diameter of the spherical crown is 20 mm.
Furthermore, the transducer adopts a radial vibration mode, and the working frequency range is 90kHz-120kHz.
Still further, the effective sound field area produced by the transducer is: the diameter ranges from 2mm to 8mm, and the depth ranges from 1mm to 5mm.
Still further, the transducer driving signal is sinusoidal with a frequency of 94.573kHz, resulting in an effective acoustic field region of 5.4mm diameter and 2.2mm depth.
Furthermore, the metal shell is an aluminum alloy tube, a wire is welded in the center of the convex surface of the curved piezoelectric ceramic plate, and a wire is welded on the inner wall of the aluminum alloy tube.
The application also provides a manufacturing method of the miniature transducer for shallow subcutaneous transdermal drug delivery, which specifically comprises the following steps:
s1, placing a curved piezoelectric ceramic sheet at a required position in a metal shell, wherein the concave surface of the curved piezoelectric ceramic sheet faces upwards, pouring epoxy resin into a gap between the curved piezoelectric ceramic sheet and the metal shell, standing for a period of time for curing, and connecting the metal shell and a concave electrode of the curved piezoelectric ceramic sheet by using quick-drying silver paste after the epoxy resin is cured; standing for a period of time, and waiting for the silver paste to be fully solidified, so as to ensure that the metal shell is electrically conducted with the concave electrode of the curved piezoelectric ceramic piece;
s2, sleeving a rubber tube at the upper end of a metal shell, wherein the rubber tube is partially contacted with the metal shell, uniformly stirring epoxy resin and tungsten powder according to a certain proportion, pouring the epoxy resin into the rubber tube along the tube wall after defoaming treatment, ensuring that the epoxy resin is contacted with the concave surface of the curved piezoelectric ceramic sheet, standing for a period of time for curing the epoxy resin, removing the rubber tube after curing the epoxy resin, and polishing the curved matching layer to a specified shape;
and S3, welding a wire at the center of the convex surface of the curved piezoelectric ceramic plate, and welding a wire on the inner wall of the metal shell, thereby completing the manufacture of the transducer.
Compared with the prior art, the invention creates the small transducer which can be used for shallow subcutaneous transdermal drug delivery and has the beneficial effects that:
(1) Compared with the common transducer, the small transducer for shallow subcutaneous transdermal drug delivery has the advantages that the ultrasonic action depth generated by the designed transducer is shallow, the energy utilization rate is high, and the cell damage of the ultrasonic to the deep subcutaneous part can be effectively avoided.
(2) The invention creates the small transducer which can be used for shallow subcutaneous transdermal drug delivery, and controls the action range of ultrasound through the structural design of a device; firstly, concave ceramic is used as a piezoelectric element, compared with planar ceramic, the concave ceramic-based piezoelectric device has more concentrated sound beams, and the sound focusing area is obviously shortened; and secondly, the resonant frequency of the device is regulated and controlled through the design of the diameter of the ceramic plate, so that the modulation of the action range and the action depth of a sound field is realized, and the influence of ultrasonic waves on cells at deeper subcutaneous positions is avoided as much as possible.
(3) The ultrasonic transducer provided by the invention can provide a larger ultrasonic action area under a smaller device size by utilizing the radial vibration mode combined with the curved ceramic design, and meanwhile, the area of a near field area is greatly reduced by adopting a smaller driving frequency design, the shallower ultrasonic action depth is ensured, and the damage action of an unstable sound field of the near field area on a human body is avoided.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention and do not constitute an undue limitation on the invention. In the drawings:
FIG. 1 is a schematic perspective view of a miniature transducer for use in shallow subcutaneous transdermal delivery according to an embodiment of the present invention;
FIG. 2 is a cross-sectional view of a miniaturized transducer that may be used for shallow subcutaneous transdermal delivery according to an embodiment of the present invention;
FIG. 3 is a schematic view of a curved piezoelectric ceramic of a miniature transducer for use in shallow subcutaneous transdermal delivery according to an embodiment of the present invention;
FIG. 4 is a schematic view of a curved matching layer of a miniature transducer for use in shallow subcutaneous transdermal delivery according to an embodiment of the present invention;
FIG. 5 is an impedance spectrum of a miniature transducer useful for shallow subcutaneous transdermal delivery according to an inventive embodiment of the present invention;
FIG. 6 is a graph of sound pressure distribution of a miniature transducer useful for transdermal administration of shallow skin in accordance with an embodiment of the present invention;
fig. 7 is an axial sound pressure distribution diagram of a miniature transducer for use in shallow subcutaneous transdermal delivery according to an embodiment of the present invention.
Reference numerals illustrate:
1. a curved surface matching layer; 2. curved piezoelectric ceramic piece; 3. a housing; 4. and (5) conducting wires.
Detailed Description
The present invention now will be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention disclosed herein without departing from the scope of the invention.
In the description of the present invention, it should be noted that, directions or positional relationships indicated by terms such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., are based on those shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the creation of the present invention will be understood in a specific case by those skilled in the art.
In addition, the technical features which are described below and which are involved in the various embodiments of the invention can be combined with one another as long as they do not conflict with one another.
As shown in fig. 1-4, a small transducer for transdermal drug delivery under shallow skin comprises a curved surface matching layer 1, a curved surface piezoelectric ceramic piece 2 and a shell 3, wherein the curved surface piezoelectric ceramic piece 2 is in a concave spherical crown shape, the curved surface piezoelectric ceramic piece 2 is arranged in the metal shell 3, the concave surface of the curved surface piezoelectric ceramic piece 2 faces upwards, the convex surface faces downwards, the curved surface piezoelectric ceramic piece 2 and the metal shell 3 are fixedly bonded through epoxy resin, an upper surface electrode of the curved surface piezoelectric ceramic piece 2 is connected and conducted with the metal shell 3 through quick-drying silver paste, a layer of curved surface matching layer 1 is paved on the upper surface of the curved surface piezoelectric ceramic, the curved surface matching layer 1 is bonded with the piezoelectric ceramic through epoxy resin, the curved surface matching layer 1 is matched with the curved surface piezoelectric ceramic in shape, a wire is welded on the inner wall of the metal shell 3 and the lower surface of the curved surface piezoelectric ceramic piece 2, and two wires are connected with a signal source.
Compared with the common transducer, the transducer has the advantages that the ultrasonic action depth generated by the transducer is shallow, the energy utilization rate is high, and the cell damage of ultrasonic waves to the deep subcutaneous position can be effectively avoided.
The curved surface matching layer 1 is made of a mixture of epoxy resin and tungsten powder, has acoustic impedance of 7.25MRayl and thickness of 4.785 mm.
The cross sections of the curved piezoelectric ceramic piece 2 and the curved matching layer 1 are spherical crowns. The thickness of the curved piezoelectric ceramic piece 2 is 2mm, wherein the height of the spherical crown is 2mm, and the diameter of the spherical crown is 20 mm. The thickness of the curved surface matching layer 1 is one quarter wavelength of the working frequency of the transducer, wherein the height of the spherical crown is 2mm, and the diameter of the spherical crown is 20 mm.
The transducer adopts a radial vibration mode, and the working frequency range is 90kHz-120kHz. The effective sound field area generated by the transducer is as follows: the diameter ranges from 2mm to 8mm, and the depth ranges from 1mm to 5mm. The transducer drive signal was sinusoidal with a frequency of 94.573kHz, producing an effective acoustic field region of 5.4mm diameter and 2.2mm depth.
The metal shell 3 is an aluminum alloy tube, a wire 4 is welded in the center of the convex surface of the curved piezoelectric ceramic plate 2, and a wire 4 is welded on the inner wall of the aluminum alloy tube.
Compared with the common transducer, the ultrasonic transducer has the advantages that the ultrasonic action depth is shallower, the energy utilization rate is high, the cell damage of the ultrasonic to the subcutaneous deeper part can be effectively avoided, the ultrasonic action range is controlled, and the influence of ineffective ultrasonic to the human body is reduced.
The manufacturing method of the miniature transducer for shallow subcutaneous transdermal drug delivery specifically comprises the following steps:
s1, placing a curved piezoelectric ceramic piece 2 at a required position in a metal shell 3, wherein the concave surface of the curved piezoelectric ceramic piece 2 faces upwards, pouring epoxy resin into a gap between the curved piezoelectric ceramic piece 2 and the metal shell 3, standing for a period of time for curing, and connecting the metal shell 3 and a concave electrode of the curved piezoelectric ceramic piece 2 by using quick-drying silver paste after the epoxy resin is cured; standing for a period of time, and waiting for the silver paste to be fully solidified, so as to ensure that the metal shell 3 is electrically conducted with the concave electrode of the curved piezoelectric ceramic piece 2;
s2, sleeving a rubber tube at the upper end of the metal shell 3, wherein the rubber tube is partially contacted with the metal shell 3, uniformly stirring epoxy resin and tungsten powder according to a certain proportion, pouring the epoxy resin into the rubber tube along the tube wall after defoaming treatment, ensuring that the epoxy resin is contacted with the concave surface of the curved piezoelectric ceramic sheet 2, standing for a period of time, waiting for curing of the epoxy resin, removing the rubber tube after curing of the epoxy resin, and polishing the curved matching layer 1 to a specified shape;
and S3, welding a wire at the center of the convex surface of the curved piezoelectric ceramic plate 2, and welding a wire on the inner wall of the metal shell 3, thereby completing the manufacture of the transducer.
A specific method for preparing a miniature transducer for shallow subcutaneous transdermal administration is provided below, comprising the steps of:
s1, placing a curved piezoelectric ceramic plate 2 with the spherical crown height of 2mm, the spherical crown diameter of 20 mm and the thickness of 2mm in an aluminum alloy pipe with the inner diameter of 20.5 mm, the outer diameter of 21.5 mm and the height of 25 mm at a required position, namely a position 5mm away from the upper end surface of the aluminum alloy pipe, with the concave surface of the curved piezoelectric ceramic plate 2 upwards, pouring epoxy resin into a gap between the curved piezoelectric ceramic plate 2 and a metal shell 3, standing for 24 hours for curing, and connecting the metal shell 3 and a concave electrode of the curved piezoelectric ceramic plate 2 by using quick-drying silver paste after the epoxy resin is cured; standing for 4h, and waiting for the silver paste to be fully solidified, so as to ensure that the metal shell 3 is electrically conducted with the concave electrode of the curved piezoelectric ceramic piece 2;
s2, sleeving a rubber tube with the length of 6 mm and the diameter of 21 mm at the upper end of the metal shell 3, wherein the rubber tube part is in contact with the metal shell 3, and then, mixing epoxy resin and tungsten powder according to the mass ratio of 1:5, uniformly stirring, pouring epoxy resin into the rubber tube along the tube wall after the defoaming treatment, standing for 24 hours to cure the epoxy resin, removing the rubber tube after the epoxy resin is cured, and polishing the curved surface matching layer 1 to a specified shape;
and S3, welding a wire at the center of the convex surface of the curved piezoelectric ceramic plate 2, and welding a wire on the inner wall of the metal shell 3, thereby completing the manufacture of the transducer.
As shown in fig. 5, an impedance spectrum of a small transducer that can be used for shallow subcutaneous transdermal drug delivery is shown, and the frequency of the driving signal of the transducer is 94.573kHz according to the impedance spectrum;
for the sound field emitted by the transducer manufactured as described above, as shown in the sound pressure distribution diagram of a small transducer for shallow subcutaneous transdermal drug delivery in fig. 6, it can be seen that the sound field is mainly distributed in the range of 5.4mm in diameter, and then the intensity is rapidly reduced;
the axial sound pressure distribution diagram of a small transducer for shallow subcutaneous transdermal drug delivery, as shown in fig. 7, for the sound field emitted by the transducer fabricated as described above, can be derived from the results of fig. 5-7: the sound field is mainly distributed in the depth range of 2.2mm below the skin, after which the intensity drops rapidly.
Through the graph, the transducer can greatly reduce the area of a near field region, ensure shallower ultrasonic action depth, avoid the injury effect of an unstable sound field of the near field region on a human body, and is particularly suitable for the operation of shallow subcutaneous transdermal drug delivery.
The inventive embodiments of the present invention disclosed above are merely intended to help illustrate the present invention. The examples are not intended to be exhaustive or to limit the invention to the precise form disclosed. Many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best understand and utilize the invention.
Claims (5)
1. A miniature transducer for use in shallow subcutaneous transdermal delivery, comprising: the device comprises a curved surface matching layer (1), a curved surface piezoelectric ceramic piece (2) and a shell (3), wherein the curved surface piezoelectric ceramic piece (2) is in a concave spherical crown shape, the curved surface piezoelectric ceramic piece (2) is arranged in the metal shell (3), the concave surface of the curved surface piezoelectric ceramic piece (2) faces upwards, the convex surface of the curved surface piezoelectric ceramic piece faces downwards, the curved surface piezoelectric ceramic piece (2) is fixedly bonded with the metal shell (3) through epoxy resin, an upper surface electrode of the curved surface piezoelectric ceramic piece (2) is connected and conducted with the metal shell (3) through quick-drying silver paste, a layer of curved surface matching layer (1) is paved on the upper surface of the curved surface piezoelectric ceramic piece, the curved surface matching layer (1) is bonded with the curved surface piezoelectric ceramic piece through epoxy resin, the curved surface matching layer (1) is matched with the shape of the curved surface piezoelectric ceramic piece, a wire is welded on the lower surface of the curved surface piezoelectric ceramic piece (2) and the inner wall of the metal shell (3), and two wires are connected with a signal source;
the curved surface matching layer (1) is made of a mixture of epoxy resin and tungsten powder, has acoustic impedance of 7.25MRayl and thickness of 4.785 mm; the thickness of the curved piezoelectric ceramic piece (2) is 2mm, wherein the height of the spherical crown is 2mm, and the diameter of the spherical crown is 20 mm; the thickness of the curved surface matching layer (1) is one quarter wavelength of the working frequency of the transducer, wherein the height of the spherical crown is 2mm, and the diameter of the spherical crown is 20 mm; the transducer adopts a radial vibration mode, the working frequency range is 90kHz-100kHz, and the effective sound field area generated by the transducer is as follows: the diameter ranges from 2mm to 8mm, and the depth ranges from 1mm to 5mm.
2. A miniature transducer for use in shallow subcutaneous transdermal delivery according to claim 1, wherein: the cross sections of the curved piezoelectric ceramic piece (2) and the curved matching layer (1) are spherical crowns.
3. A miniature transducer for use in shallow subcutaneous transdermal delivery according to claim 1, wherein: the transducer drive signal was sinusoidal with a frequency of 94.573kHz, producing an effective acoustic field region of 5.4mm diameter and 2.2mm depth.
4. A miniature transducer for use in shallow subcutaneous transdermal delivery according to claim 1, wherein: the metal shell (3) is an aluminum alloy tube, a wire (4) is welded in the center of the convex surface of the curved piezoelectric ceramic plate (2), and a wire (4) is welded on the inner wall of the aluminum alloy tube.
5. A method of manufacturing a miniature transducer for use in transdermal drug delivery under the skin according to any of claims 1-4, wherein: the method specifically comprises the following steps:
s1, placing a curved piezoelectric ceramic sheet (2) at a required position in a metal shell (3), wherein the concave surface of the curved piezoelectric ceramic sheet (2) faces upwards, pouring epoxy resin into a gap between the curved piezoelectric ceramic sheet (2) and the metal shell (3), standing for a period of time for curing, and connecting the metal shell (3) and a concave electrode of the curved piezoelectric ceramic sheet (2) by using quick-drying silver paste after the epoxy resin is cured; standing for a period of time, and waiting for the silver paste to be fully solidified, so as to ensure that the metal shell (3) is electrically conducted with the concave electrode of the curved piezoelectric ceramic piece (2);
s2, sleeving a rubber tube at the upper end of the metal shell (3), wherein the rubber tube is partially contacted with the metal shell (3), uniformly stirring epoxy resin and tungsten powder according to a certain proportion, pouring the epoxy resin into the rubber tube along the tube wall after defoaming treatment, ensuring that the epoxy resin is contacted with the concave surface of the curved piezoelectric ceramic piece (2), standing for a period of time to cure the epoxy resin, removing the rubber tube after curing the epoxy resin, and polishing the curved matching layer (1) to a specified shape;
and S3, welding a wire at the center of the convex surface of the curved piezoelectric ceramic piece (2), and welding a wire on the inner wall of the metal shell (3) so as to finish the manufacturing of the transducer.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210550607.1A CN115105738B (en) | 2022-05-20 | 2022-05-20 | Small transducer for shallow subcutaneous transdermal drug delivery and manufacturing method thereof |
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| CN202210550607.1A CN115105738B (en) | 2022-05-20 | 2022-05-20 | Small transducer for shallow subcutaneous transdermal drug delivery and manufacturing method thereof |
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| CN115105738B true CN115105738B (en) | 2024-03-19 |
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| CN115624690B (en) * | 2022-10-14 | 2023-10-31 | 江苏省声学产业技术创新中心 | Bowl-shaped piezoelectric ceramic structure for transdermal drug delivery instrument and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2796747Y (en) * | 2005-05-26 | 2006-07-19 | 深圳市普罗惠仁医学科技有限公司 | Spherical crown type concave ball surface ultrasonic transducer |
| CN102580261A (en) * | 2012-03-31 | 2012-07-18 | 上海交通大学 | Focusing ultrasonic transducer device for treating superficial tumor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7824348B2 (en) * | 2004-09-16 | 2010-11-02 | Guided Therapy Systems, L.L.C. | System and method for variable depth ultrasound treatment |
| CA2799760C (en) * | 2010-05-21 | 2019-10-08 | Misonix Incorporated | Ultrasonic transducer assembly |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2796747Y (en) * | 2005-05-26 | 2006-07-19 | 深圳市普罗惠仁医学科技有限公司 | Spherical crown type concave ball surface ultrasonic transducer |
| CN102580261A (en) * | 2012-03-31 | 2012-07-18 | 上海交通大学 | Focusing ultrasonic transducer device for treating superficial tumor |
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