CN115097089B - Metering method and system of medicine disintegration time limit tester - Google Patents
Metering method and system of medicine disintegration time limit tester Download PDFInfo
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- CN115097089B CN115097089B CN202211022304.9A CN202211022304A CN115097089B CN 115097089 B CN115097089 B CN 115097089B CN 202211022304 A CN202211022304 A CN 202211022304A CN 115097089 B CN115097089 B CN 115097089B
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- 239000003814 drug Substances 0.000 title claims abstract description 109
- 238000000034 method Methods 0.000 title claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 99
- 238000012360 testing method Methods 0.000 claims abstract description 73
- 239000000126 substance Substances 0.000 claims abstract description 52
- 238000005259 measurement Methods 0.000 claims abstract description 26
- 238000009507 drug disintegration testing Methods 0.000 claims abstract description 9
- 230000003749 cleanliness Effects 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 4
- 239000004744 fabric Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 abstract description 3
- 229920003023 plastic Polymers 0.000 description 7
- 229910001220 stainless steel Inorganic materials 0.000 description 7
- 239000010935 stainless steel Substances 0.000 description 5
- 238000009529 body temperature measurement Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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Abstract
The application discloses a metering method and a metering system of a medicine disintegration time limit tester, wherein the metering method comprises an input module, an ambient temperature measuring module, a water adding volume measuring module, a water temperature measuring module, a tester metering disintegration time limit theoretical test calculating module, a standard substance disintegration actual time limit obtaining module, a deviation calculating module, a deviation comparing module and an output module, wherein a standard substance disintegration time limit theoretical test result is obtained through the tester metering disintegration time limit theoretical test calculating module, the standard substance is put into the medicine disintegration time limit tester for disintegration test, and the standard substance disintegration time limit actual result is obtained through detection; and comparing the actual result of the disintegration time limit of the standard substance with the theoretical test result of the disintegration time limit of the standard substance, and determining that the metering precision of the drug disintegration time limit tester is accurate. The application has high repeatability and high measurement precision.
Description
Technical Field
The application relates to a metering method and a metering system for a medicine disintegration time limit tester, which are used for evaluating and calibrating metering performance of the medicine disintegration time limit tester, and belong to the technical field of metering detection.
Background
The existing medicine disintegration time tester (hereinafter referred to as a disintegration tester) is a medicine inspection instrument prescribed in the pharmacopoeia of the people's republic of China (2020 edition) annex 0921 "disintegration time inspection method", and is used for inspecting the disintegration condition of a solid preparation under prescribed conditions. Specifically, a lifting type disintegrating instrument which accords with the regulation of mechanical parameters of pharmacopoeia is adopted, and the main structure is a lifting metal bracket, a hanging basket with a screen mesh embedded at the lower end and a baffle plate.
The main mechanical parameters of the medicine disintegration time limit tester are mainly as follows:
(1) The up-and-down moving distance of the lifting metal bracket is 55mm plus or minus 2mm, and the round-trip frequency is 31 times per minute.
(2) 6 hanging basket glass tubes with the length of 77.5 mm plus or minus 2.5mm, the inner diameter of 21.5mm and the wall thickness of 2mm; 2 transparent plastic plates with the diameter of 90mm and the thickness of 6mm, and 6 holes with the aperture of 26mm are arranged on the plate surface; stainless steel plate 1 (put on a plastic plate above) with diameter of 90mm, thickness of 1mm, 6 holes on the plate surface and aperture of 22mm; stainless steel wire screen 1 (under a plastic plate below), diameter 90mm, sieve pore inner diameter 2.0mm; and 1 stainless steel shaft (fixed on the upper plastic plate and the stainless steel plate) with the length of 80mm. The 6 glass tubes were placed vertically in holes of 2 plastic plates, and the stainless steel plates, plastic plates and stainless steel wire mesh were fixed with 3 screws.
(3) The baffle is a smooth transparent plastic block, the relative density is 1.18-1.20, the diameter is 20.7mm plus or minus 0.15 mm, and the thickness is 9.5mm plus or minus 0.15 mm; the baffle has 5 holes, the aperture is 2mm, the center is 1 hole, the distance between the other 4 holes is 6mm, and the distance between the holes is equal; the side of the baffle is provided with 4 equidistant V-shaped grooves, the width of the upper end of each V-shaped groove is 9.5mm, the depth of each V-shaped groove is 2.55mm, and the width and the depth of the opening at the bottom are both 1.6mm.
The medicine disintegration time limit tester performs regular calibration work according to jjjf 1449-2014 calibration standard of the disintegration time limit tester, wherein 'indication error and repeatability' are important indexes for evaluating the metering performance of the medicine disintegration time limit tester by the calibration standard.
In the standard implementation process, the operation of an experimenter has great influence on the test repeatability result of the medicine disintegration time limit tester, and if the operation is not strict, the test repeatability result of the medicine disintegration time limit tester by different time and different personnel is very different, so that the test repeatability index of the instrument cannot be truly embodied.
Disclosure of Invention
The application aims to: in order to overcome the defects in the prior art, the application provides a metering method and a metering system of a medicine disintegration time limit tester, which have high repeatability and high measurement precision.
The technical scheme is as follows: in order to achieve the above purpose, the application adopts the following technical scheme:
a metering method of a medicine disintegration time tester comprises the following steps:
step 1, detecting the actual environment temperature of a medicine disintegration time limit tester。
Step 2, test for detecting disintegration time limit of medicineVolume of water actually added in beaker in instrumentAnd the actual water temperature of the water in the beaker +.>。
Step 3, according to the detected actual ambient temperatureVolume of actually added water->Actual water temperature of water in beaker +.>Cleanliness of the screen>Establishing a tester metering disintegration time limit model:
wherein ,is the test result of the standard substance disintegration time limit theory>Is the standard value of disintegration time limit of standard substance and is prepared from->For the influence of the metering performance of the medicine disintegration time tester, < + >>For the actual temperature of the water in the beaker,/>for the volume of water actually added in the beaker, +.>Adding the influence coefficient of the water volume to the beaker, < >>Adding water to the optimal volume of the beaker of the medicine disintegration time tester,is the influence coefficient of the ambient temperature, +.>For the actual ambient temperature>For the influence coefficient of the degree of cleanliness of the basket screen of the disintegration time tester, +.>Is a random number +.>，/>Is the cleanliness of the screen mesh in the medicine disintegration time tester.
Step 4, placing the standard substance into a medicine disintegration time tester for disintegration test, and detecting to obtain the actual result of the disintegration time of the standard substance。
Step 5, actual results of disintegration time limit of the standard substanceResults of theoretical test on disintegration time with Standard substance +.>Comparing to obtain the metering deviation of the medicine disintegration time limit tester:
wherein ,indicating the metering deviation of the tester for the disintegration time of the medicine.
Step 6, measuring deviation of the medicine disintegration time limit testerCompared to a deviation grant range. If the medicine disintegrates, the measuring deviation of the tester is +.>And if the deviation is in the allowable range, the accuracy of the metering precision of the medicine disintegration time limit tester is indicated. If the medicine disintegrates, the measuring deviation of the tester is +.>If the measurement accuracy is not in the allowable deviation range, the measurement accuracy of the tester is poor when the medicine disintegrates.
Preferably: range of influence of metering performance of the drug disintegration time tester:。
preferably: the optimal volume range of water added to the beaker of the drug disintegration time tester:。
preferably: screen meshIs not limited by the range of cleanliness:。
the utility model provides a medicine disintegration time limit tester metering system, includes input module, ambient temperature measurement module, water volume measurement module, temperature measurement module, tester measurement disintegration time limit theoretical test calculation module, standard substance disintegration actual time limit acquisition module, deviation calculation module, deviation comparison module, output module, wherein:
the input module is used for inputting the standard substance disintegration time limit standard valueMeter Performance Effect of drug disintegration time tester>Optimal volume of beaker added with water of medicine disintegration time tester>Cleanliness of screen in tester for medicine disintegration time>And transmitting the input information to a tester metering disintegration time limit theoretical test calculation module.
The environment temperature measuring module is used for measuring the actual environment temperature of the medicine disintegration time limit tester during testingAnd measuring the actual ambient temperature +.>And transmitting the measured disintegration time limit theoretical test calculation module to a tester.
The water adding volume measuring module is used for measuring actual adding of the medicine disintegration time limit tester into the beaker during testingVolume of waterAnd the volume of water actually added in the measured beaker is +.>And transmitting the measured disintegration time limit theoretical test calculation module to a tester.
The water temperature measuring module is used for measuring the actual water temperature of water in the beaker when the medicine disintegration time limit tester testsAnd the measured actual water temperature of the water in the beaker is +.>And transmitting the measured disintegration time limit theoretical test calculation module to a tester.
The tester metering disintegration time limit theoretical test calculation module is embedded with a tester metering disintegration time limit model, and the tester metering disintegration time limit theoretical test calculation module is used for calculating the actual environment temperatureVolume of water actually added to beakerActual water temperature of water in beaker +.>Obtaining a standard substance disintegration time limit theoretical test result by measuring a disintegration time limit model by a tester>And will obtain the theoretical test result of disintegration time limit of the standard substance +.>Send to deviationAnd a calculation module.
The standard substance disintegration time limit acquisition module is used for acquiring the actual result of the standard substance disintegration time limit obtained by the disintegration test of the drug disintegration time limit testerAnd will give the actual result of disintegration time of the standard substance +.>And sending the result to a deviation calculation module.
The deviation calculation module is used for calculating the actual result of the disintegration time limit of the standard substanceResults of theoretical test on disintegration time with Standard substance +.>Comparing to obtain the metering deviation of the medicine disintegration time tester>And will obtain the measuring deviation of the medicine disintegration time tester>And sending the result to a deviation comparison module.
The deviation comparison module is used for measuring deviation of the medicine disintegration time limit testerCompared to a deviation grant range. If the medicine disintegrates, the measuring deviation of the tester is +.>And if the deviation is in the allowable range, sending accurate measurement precision information of the medicine disintegration time limit tester to the output module. If the medicine disintegrates, the measuring deviation of the tester is +.>And if the medicine disintegration time limit tester is not in the deviation permission range, sending the measurement precision difference information of the medicine disintegration time limit tester to an output module.
The output module is used for outputting accurate measurement precision information of the medicine disintegration time limit tester or measurement precision difference information of the medicine disintegration time limit tester, which are sent by the deviation comparison module.
Preferably: the deviation calculation module is used for measuring deviation of the obtained medicine disintegration time limit testerAnd sending the data to an output module. The output module is used for outputting the metering deviation +.>。
Compared with the prior art, the application has the following beneficial effects:
the application considers the actual environment temperature, the volume of the actually added water, the actual water temperature of the water, the cleanliness of the screen and the standard substance disintegration time limit standard value, thereby avoiding the influence of human factors, ensuring that the theoretical result is more accurate, and the metering precision of the medicine disintegration time limit tester is higher, so the repeatability and the measuring precision are high.
Drawings
Fig. 1 is a schematic structural view of the present application.
Detailed Description
The present application is further illustrated in the accompanying drawings and detailed description which are to be understood as being merely illustrative of the application and not limiting of its scope, and various equivalent modifications to the application will fall within the scope of the application as defined in the appended claims after reading the application.
A metering method of a medicine disintegration time tester comprises the following steps:
step 1, detecting the actual environment temperature of a medicine disintegration time limit tester。
Step 2, detecting the volume of water actually added into a beaker in a medicine disintegration time testerAnd the actual water temperature of the water in the beaker +.>。
Water level check
Before testing, hanging the hanging basket on the bracket through the stainless steel shaft at the upper end, immersing the hanging basket in a 1000mL beaker, adjusting the position of the hanging basket to enable the screen to be 25mm away from the bottom of the beaker when the hanging basket descends to a low point, and adjusting the height of the water level to enable the screen to be 15mm below the water surface when the hanging basket ascends to a high point, wherein the top of the hanging basket cannot be immersed in the solution.
The amount of water added to the beaker determines the distance of the screen from the bottom of the beaker when the basket is lowered to the low point and the distance of the screen below the water surface when the basket is raised to the high point. When the hanging basket rises to a high point, the screen is more than 15mm away from the water surface, and when the hanging basket rises to the high point, the impact force of the baffle on the standard sheet is reduced, so that the disintegration time of the standard product is prolonged. When the hanging basket rises to a high point, the distance between the screen and the water surface is slightly less than 15mm, the impact force of the baffle on the standard sheet is increased, and the disintegration time of the standard sheet is shortened. If the water content in the beaker is obviously insufficient, the standard tablet is exposed to the water surface when the hanging basket rises to a high point, and the unpredictable influence is also caused on the disintegration time of the standard tablet. Therefore, before testing, through water quantity control and repeated testing, when the water quantity in the beaker is about 800 mL, the distance between the screen of the lifting disintegration tester and the water surface at the high point of the hanging basket and the distance between the screen of the lifting disintegration tester and the bottom of the beaker can meet pharmacopoeia regulations.
Therefore, the measuring cylinder is used for marking the water volume meeting the requirement, the water volume added in the test beaker each time is ensured to be consistent, the distance is checked rapidly, and the consistency of the analysis result can be better ensured.
Temperature control content
The temperature sensors of the lifting type disintegrating instrument are all located in the water bath environment instead of the beaker, so that a thermometer is required to monitor the water temperature in the beaker before testing.
Because the water bath environment is relatively closed, and the beaker environment is relatively open, experiments show that the water temperature in the beaker is about 1 ℃ lower than the set temperature of the instrument (namely, the temperature measured by an instrument temperature sensor), and the temperature difference is related to the instrument structure and is embodied on all lifting disintegrating instruments.
Meanwhile, the water temperature in the beaker has obvious correlation with the disintegration time of the standard tablet, the actual temperature of the water in the beaker is recorded by changing the set temperature of the instrument, the test work of the standard tablet is carried out, 12 standard tablets are tested at one time, the average value is taken, the detection data are shown in the following table 1, and the result shows that the higher the water temperature in the beaker is, the shorter the disintegration time of the standard tablet is.
TABLE 1 influence of temperature on disintegration values
In order to ensure the reproducibility of the measurement result of the analysis method, the laboratory temperature is controlled to be 25+/-1 ℃, the consistency of the temperature of the environment and the temperature of water in the beaker is ensured, meanwhile, the water temperature in the beaker is actually monitored before each test, and researches show that the time for the instrument to reach the temperature balance at the first starting up is about 90min, the balancing time after the water in the beaker is replaced for each test is about 40min, and the consistency of the water temperature in the beaker is ensured through the monitoring of the balancing time and the water temperature, so that the reproducibility of the measurement result of the analysis method is better ensured.
Step 3, according to the detected actual ambient temperatureVolume of actually added water->Actual water temperature of water in beaker +.>Cleanliness of the screen>Establishing a tester metering disintegration time limit model:
wherein ,is the test result of the standard substance disintegration time limit theory>Is the standard value of disintegration time limit of standard substance and is prepared from->For the influence of the metering performance of the medicine disintegration time tester, < + >>，/>Is the actual temperature of the water in the beaker, +.>For the volume of water actually added in the beaker, +.>Adding the influence coefficient of the water volume to the beaker, < >>Adding water to the optimum volume of beaker of the tester for medicine disintegration time limit, < >>，/>Is the influence coefficient of the ambient temperature, +.>For the actual ambient temperature>For the influence coefficient of the degree of cleanliness of the basket screen of the disintegration time tester, +.>Is a random number +.>，/>For the cleanliness of the screen mesh in the medicine disintegration time tester, < > for the medicine disintegration time tester>。
Screen status inspection: in the primary test, the standard sheet has certain viscosity, and the screen is stained after multiple tests, so that the pore diameter of part of the screen pores is changed, and the test shows that the standard sheet always completes disintegration at the site of the stained screen, and systematic errors are caused. Therefore, two optimization works are mainly carried out, namely, a more suitable material is selected for preparing the standard sheet, and the currently selected material has low viscosity, is easy to clean and is not easy to adhere to the screen. And secondly, repeatedly flushing the screen after the test is carried out. After optimization, the hole sites of the standard tablet disintegration in each test are completely random, which shows that the optimization effect is good.
Step 4, placing the standard substance into a medicine disintegration time tester for disintegration test, and detecting to obtain the actual result of the disintegration time of the standard substance。
Step 5, actual results of disintegration time limit of the standard substanceResults of theoretical test on disintegration time with Standard substance +.>Comparing to obtain the metering deviation of the medicine disintegration time limit tester:
wherein ,indicating the metering deviation of the tester for the disintegration time of the medicine.
Step 6, measuring deviation of the medicine disintegration time limit testerCompared to a deviation grant range. If the medicine disintegrates, the measuring deviation of the tester is +.>And if the deviation is in the allowable range, the accuracy of the metering precision of the medicine disintegration time limit tester is indicated. If the medicine disintegrates, the measuring deviation of the tester is +.>If the measurement accuracy is not in the allowable deviation range, the measurement accuracy of the tester is poor when the medicine disintegrates.
The utility model provides a medicine disintegration time limit tester metering system, as shown in fig. 1, includes input module, ambient temperature measurement module, water volume measurement module, temperature measurement module, tester measurement disintegration time limit theoretical test calculation module, standard substance disintegration actual time limit acquisition module, deviation calculation module, deviation comparison module, output module, wherein:
the input module is used for inputting the standard substance disintegration time limit standard valueMeter Performance Effect of drug disintegration time tester>Optimal volume of beaker added with water of medicine disintegration time tester>Cleanliness of screen in tester for medicine disintegration time>And transmitting the input information to a tester metering disintegration time limit theoretical test calculation module.
The environment temperature measuring module is used for measuring the actual environment temperature of the medicine disintegration time limit tester during testingAnd measuring the actual ambient temperature +.>And transmitting the measured disintegration time limit theoretical test calculation module to a tester.
The water adding volume measuring module is used for measuring the volume of water actually added into the beaker when the medicine disintegration time limit tester testsAnd the volume of water actually added in the measured beaker is +.>And transmitting the measured disintegration time limit theoretical test calculation module to a tester.
The water temperature measuring module is used for measuring the actual water temperature of water in the beaker when the medicine disintegration time limit tester testsAnd the measured actual water temperature of the water in the beaker is +.>And transmitting the measured disintegration time limit theoretical test calculation module to a tester.
The tester metering disintegration time limit theoretical test calculation module is embedded with a tester metering disintegration time limit model, and the tester metering disintegration time limit theoretical test calculation module is used for calculating the actual environment temperatureVolume of water actually added to beakerActual water temperature of water in beaker +.>Obtaining a standard substance disintegration time limit theoretical test result by measuring a disintegration time limit model by a tester>And will obtain the theoretical test result of disintegration time limit of the standard substance +.>And sending the result to a deviation calculation module.
The standard substance disintegration time limit acquisition module is used for acquiring the actual result of the standard substance disintegration time limit obtained by the disintegration test of the drug disintegration time limit testerAnd will give the actual result of disintegration time of the standard substance +.>And sending the result to a deviation calculation module.
The deviation calculation module is used for calculating the actual result of the disintegration time limit of the standard substanceResults of theoretical test on disintegration time with Standard substance +.>Comparing to obtain the metering deviation of the medicine disintegration time tester>And will obtain the measuring deviation of the medicine disintegration time tester>And sending the result to a deviation comparison module. The deviation calculation module is used for obtaining the metering deviation of the medicine disintegration time limit tester>And sending the data to an output module.
The deviation comparison module is used for measuring deviation of the medicine disintegration time limit testerCompared to a deviation grant range. If the medicine disintegrates, the measuring deviation of the tester is +.>And if the deviation is in the allowable range, sending accurate measurement precision information of the medicine disintegration time limit tester to the output module. If the medicine disintegrates, the measuring deviation of the tester is +.>If the medicine disintegration time limit tester is not in the deviation permission range, the medicine disintegration time limit tester metering essence is sent to an output moduleAnd (5) degree difference information.
The output module is used for outputting accurate measurement precision information of the medicine disintegration time limit tester or measurement precision difference information of the medicine disintegration time limit tester, which are sent by the deviation comparison module. The output module is used for outputting the metering deviation of the medicine disintegration time limit tester。
TABLE 2 data measured by different personnel at different times
As shown in Table 2, the test results of different persons on the same medicine disintegration time limit tester at different times show that the test results of different persons on the same medicine disintegration time limit tester at different times have good consistency.
The foregoing is only a preferred embodiment of the application, it being noted that: it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the principles of the present application, and such modifications and adaptations are intended to be comprehended within the scope of the application.
Claims (3)
1. The metering method of the medicine disintegration time tester is characterized by comprising the following steps of:
step 1, detecting the actual environment temperature of a medicine disintegration time limit tester；
Step 2, detecting the volume of water actually added into a beaker in a medicine disintegration time testerAnd the actual water temperature of the water in the beaker；
Step 3, according to the detected actual ambient temperatureVolume of actually added water->Actual water temperature of water in beakerCleanliness of the screen>Establishing a tester metering disintegration time limit model:
；
wherein ,is the test result of the standard substance disintegration time limit theory>Is the standard value of disintegration time limit of standard substance and is prepared from->The influence of the metering performance of the medicine disintegration time limit tester is as follows:，/>is the actual temperature of the water in the beaker, +.>For the volume of water actually added in the beaker, +.>Adding the influence coefficient of the water volume to the beaker, < >>The optimal volume of water added into the beaker of the medicine disintegration time limit tester is as follows: />，/>Is an influence coefficient of the ambient temperature,for the actual ambient temperature>For the influence coefficient of the degree of cleanliness of the basket screen of the disintegration time tester, +.>In the form of a random number,，/>for the cleanliness factor of screen cloth in the medicine disintegration time limit tester, the range of cleanliness factor of screen cloth is:；
step 4, placing the standard substance into a medicine disintegration time tester for disintegration test, and detecting to obtain the actual result of the disintegration time of the standard substance；
Step 5, actual results of disintegration time limit of the standard substanceResults of theoretical test on disintegration time with Standard substance +.>Comparing to obtain the metering deviation of the medicine disintegration time limit tester:
；
wherein ,the metering deviation of the tester for the disintegration time of the medicine is represented;
step 6, measuring deviation of the medicine disintegration time limit testerComparing with a deviation allowable range; if the medicine disintegrates, the measuring deviation of the tester is +.>The measurement accuracy of the tester for the medicine disintegration time limit is accurate when the deviation is in the allowable range; if the medicine disintegrates, the measuring deviation of the tester is +.>If the measurement accuracy is not in the allowable deviation range, the measurement accuracy of the tester is poor when the medicine disintegrates.
2. A metering system based on the metering method of the pharmaceutical disintegration time tester according to claim 1, characterized in that: the system comprises an input module, an ambient temperature measuring module, a water adding volume measuring module, a water temperature measuring module, a tester metering disintegration time limit theoretical test calculating module, a standard substance disintegration actual time limit acquiring module, a deviation calculating module, a deviation comparing module and an output module, wherein:
the input module is used for inputting the standard substance disintegration time limit standard valueMeter Performance Effect of drug disintegration time tester>Optimal volume of beaker added with water of medicine disintegration time tester>Cleanliness of screen in tester for medicine disintegration time>The input information is transmitted to a tester metering disintegration time limit theoretical test calculation module;
the environment temperature measuring module is used for measuring the actual environment temperature of the medicine disintegration time limit tester during testingAnd measuring the actual ambient temperature +.>Transmitting the measured disintegration time limit theoretical test calculation module to a tester;
the water adding volume measuring module is used for measuring the volume of water actually added into the beaker when the medicine disintegration time limit tester testsAnd the volume of water actually added in the measured beaker is +.>Transmitting the measured disintegration time limit theoretical test calculation module to a tester;
the water temperature measuring module is used for measuring water in the beaker when the medicine disintegration time limit tester testsIs the actual water temperature of (a)And the measured actual water temperature of the water in the beaker is +.>Transmitting the measured disintegration time limit theoretical test calculation module to a tester;
the tester metering disintegration time limit theoretical test calculation module is embedded with a tester metering disintegration time limit model, and the tester metering disintegration time limit theoretical test calculation module is used for calculating the actual environment temperatureThe volume of water actually added in the beaker +.>Actual water temperature of water in beaker +.>Obtaining a standard substance disintegration time limit theoretical test result by measuring a disintegration time limit model by a tester>And will obtain the theoretical test result of disintegration time limit of the standard substance +.>Sending the deviation to a deviation calculation module;
the standard substance disintegration time limit acquisition module is used for acquiring the actual result of the standard substance disintegration time limit obtained by the disintegration test of the drug disintegration time limit testerAnd will give the actual result of disintegration time of the standard substance +.>Sending the deviation to a deviation calculation module;
the deviation calculation module is used for calculating the actual result of the disintegration time limit of the standard substanceResults of theoretical test on disintegration time with Standard substance +.>Comparing to obtain the metering deviation of the medicine disintegration time tester>And will obtain the measuring deviation of the medicine disintegration time tester>Sending the deviation comparison module;
the deviation comparison module is used for measuring deviation of the medicine disintegration time limit testerComparing with a deviation allowable range; if the medicine disintegrates, the measuring deviation of the tester is +.>In the deviation permission range, the accurate measurement precision information of the medicine disintegration time limit tester is sent to the output module; if the medicine disintegrates, the measuring deviation of the tester is +.>If the medicine disintegration time limit tester is not in the deviation permission range, sending the measurement precision difference information of the medicine disintegration time limit tester to an output module;
the output module is used for outputting accurate measurement precision information of the medicine disintegration time limit tester or measurement precision difference information of the medicine disintegration time limit tester, which are sent by the deviation comparison module.
3. The metering system of claim 2, wherein: the deviation calculation module is used for obtaining medicineMetering deviation of product disintegration time testerSending the data to an output module; the output module is used for outputting the metering deviation +.>。
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| CN207832780U (en) * | 2018-01-19 | 2018-09-07 | 天津胜鉴计量检测技术服务有限公司 | Integrated form disintegration time limited tester calibration device based on optical correction |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207832780U (en) * | 2018-01-19 | 2018-09-07 | 天津胜鉴计量检测技术服务有限公司 | Integrated form disintegration time limited tester calibration device based on optical correction |
Non-Patent Citations (1)
| Title |
|---|
| 升降式崩解仪校准方法探讨;刘亚杰等;《中国计量》;20160331(第3期);第110-111页 * |
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