CN115089891A - Device for stimulating caudate nucleus in brain to improve nervous system excitability - Google Patents
Device for stimulating caudate nucleus in brain to improve nervous system excitability Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0622—Optical stimulation for exciting neural tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0632—Constructional aspects of the apparatus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
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Abstract
The present invention provides a device for stimulating the caudate nucleus in the brain to increase nervous system excitability, comprising: the infrared spot frequency light source module is used for generating high-power infrared light with the wavelength of 8.5 microns and the optical power of 35 mW; the optical fiber coupling module is used for reducing the infrared light and carrying out focused beam processing on the infrared light based on the multi-stage focusing component to obtain focused infrared light, and the focused infrared light is collimated by the collimating component and then coupled into the optical fiber for conduction; the puncture guiding component is used for guiding the front end of the optical fiber to a specific irradiation stimulation site in the brain and irradiating the infrared light coupled into the optical fiber on the caudate nucleus in the brain. The device for stimulating the caudate nucleus in the brain to improve the excitability of the nervous system can reduce nervous system inhibition and fatigue feeling caused by excessive secretion of gamma-aminobutyric acid in the brain by stimulating the caudate nucleus in the brain through infrared light, indirectly control the excitability degree of the nervous system of an organism, and has the advantages of simple operation, safety, reliability, rapid regulation and control and short time.
Description
Technical Field
The invention relates to the technical field of biological effects of infrared light, in particular to a device for stimulating caudate nuclei in brain to improve excitability of a nervous system.
Background
Gamma-aminobutyric acid is taken as the most important inhibitory neurotransmitter widely distributed in the brain and has important significance for maintaining normal physiological functions of the brain. However, excessive secretion of γ -aminobutyric acid can decrease the activity of nerve cells, inhibit the excitability of central nerve, cause the adverse symptoms of drowsiness, stiffness, lethargy and the like, and affect the exercise level of the body. The previous research shows that the long-time movement can weaken the metabolic process of the gamma-aminobutyric acid and increase the content of the gamma-aminobutyric acid in brain tissues, thereby inhibiting central nerve cells and generating fatigue feeling. Therefore, the reduction of gamma-aminobutyric acid in the brain can improve the excitability of the nervous system and reduce the fatigue symptom of the nervous system. At present, the traditional method for regulating the change of the content of the gamma-aminobutyric acid in the brain is mostly in a medicine mode, so that the medicine is contraindicated with useful medicines, has side effects and takes effect slowly. Therefore, how to design an external stimulation device capable of efficiently and rapidly solving the problems of central nervous system excitability inhibition and the like caused by excessive gamma-aminobutyric acid secretion is a difficult problem to be solved urgently.
Disclosure of Invention
Therefore, the invention provides a device for stimulating caudate nuclei in the brain to improve nervous system excitability, and aims to solve the problems of high limitation and poor reliability of the existing drug regulation and control mode.
The present invention provides a device for stimulating the caudate nucleus in the brain to increase nervous system excitability, comprising:
the infrared spot frequency light source module is used for generating high-power infrared light with the wavelength of 8.5 microns and the light power of less than or equal to 200 mW;
the optical fiber coupling module is used for reducing and focusing the infrared light based on the multi-stage focusing component to obtain focused infrared light, and then the focused infrared light is collimated by the collimating component and then coupled into an optical fiber for conduction;
a puncture guide member for guiding the tip of the optical fiber to a specific irradiation stimulation site in the brain and irradiating the infrared light coupled into the optical fiber onto the caudate nucleus in the brain; wherein the irradiation stimulation site is caudate nucleus.
Further, the puncture guide member includes: an inner guide wire, an outer sheath and a fixed switch;
the inner guide wire is used for puncturing an irradiation stimulation site entering the brain; the tail end of the inner guide wire is provided with a buckle corresponding to the clamping groove of the outer sheath, so that the inner guide wire can be buckled with the outer sheath and can be detachably withdrawn from the outer sheath in the puncture process;
the outer sheath is used for puncturing under the guidance of the inner guide wire to place the irradiation stimulation site, and guiding the optical fiber to be placed into the irradiation stimulation site along the outer sheath after the inner guide wire is withdrawn from the outer sheath;
the fixing switch is used for fixing the optical fiber in the sheath through mechanical pressure after being closed so as to enable the optical fiber to be fixedly arranged into a corresponding depth.
Further, a tubular channel for passing and fixing the optical fiber is formed in the middle of the fixed switch after the fixed switch is closed, and the inner surface of the tubular channel is made of soft materials so as to protect the optical fiber from being damaged by mechanical pressure.
Furthermore, the fixing switch is provided with a buckle corresponding to the clamping groove on the outer sheath, so that the fixing switch can be buckled with and disassembled from the outer sheath in the process of fixing the optical fiber.
Further, the inner diameter of the sheath is 1.1mm, and the outer diameter is 1.3 mm; the sheath is made of 70-80HD materials, is transparent in color and is provided with scales on the surface.
Further, the diameter of the inner guide wire is 0.8-0.9 mm; the hardness of the material of the inner guide wire is 70-80 HD.
Further, the fiber coupling module includes: the multi-stage focusing assembly, the collimating assembly and the optical fiber;
the multistage focusing component is used for reducing the light spot of the infrared light emitted by the infrared spot frequency light source module to enable the radius of the light spot of the infrared light to be reduced to be less than or equal to 600 mu m, and then the focused infrared light is obtained; the collimation component is used for collimating the focused infrared light so that the light beam irradiates along a straight line; the optical fiber is used for conducting the collimated infrared light.
Further, the optical fiber is a multimode optical fiber, the inner diameter is 580-610 μm, the outer diameter is 900-1000 μm, and the numerical aperture is 0.3, so as to effectively transmit a light beam with a wavelength of 8.5 μm, and the power of the exit end of the optical fiber is 35 mW.
Further, the repetition frequency of the infrared light is less than or equal to 200kHz, and the pulse width is less than or equal to 2 mus.
Further, the device is configured to irradiate the infrared light on the caudate nucleus within the brain for 5 min.
According to the device for stimulating caudate nuclei in the brain to improve the excitability of the nervous system, the high-power infrared light with the wavelength of 8.5 microns and the optical power of less than or equal to 200mW is generated by the infrared dot frequency light source module; the optical fiber coupling module is used for reducing infrared light and focusing light beams based on a multi-stage focusing component to obtain focused infrared light, and the focused infrared light is collimated by a collimating component and then coupled into an optical fiber for conduction; the puncture guiding component is used for guiding infrared light with the emitting power of 35mW at the front end of the optical fiber to a specific irradiation stimulation site in the brain, the infrared light coupled into the optical fiber is irradiated on caudate nuclei in the brain, the nervous system inhibition and fatigue feeling caused by excessive secretion of gamma-aminobutyric acid in the brain can be reduced by stimulating the caudate nuclei in the brain through the infrared light, the nervous system excitation degree of organisms is indirectly controlled, and the puncture guiding component is simple to operate, safe, reliable, rapid to regulate and control and short in time.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a schematic diagram of an apparatus for stimulating caudate nuclei in the brain to increase nervous system excitability, according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a fiber coupling module according to an embodiment of the present invention;
fig. 3 is a schematic structural view of a puncture guide member provided in an embodiment of the present invention;
FIG. 4 is a schematic diagram of the physical structure of an apparatus for stimulating caudate nuclei in the brain to enhance nervous system excitability, according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of the structure of the outer sheath of the apparatus for stimulating caudate nuclei in the brain to enhance nervous system excitability, according to an embodiment of the present invention;
FIG. 6 is a schematic structural diagram of an inner guide wire of the apparatus for stimulating caudate nucleus in brain to improve nervous system excitability provided by the embodiment of the present invention;
FIG. 7 is a schematic diagram of a stationary switch in an apparatus for stimulating the caudate nucleus in the brain to enhance nervous system excitability according to an embodiment of the present invention;
FIG. 8 is a graph showing the results of gamma-aminobutyric acid (GABA) in the test group and the control group under the stimulation of a wavelength of 8.5 μm provided in the example of the present invention;
FIG. 9 is a graph showing the results of a western blot test for neuronal core antigen (NeuN) of the test group and the control group provided by the embodiment of the present invention;
fig. 10 is a graph showing analysis results of a western blot test of neuronal core antigen (NeuN) of the test group and the control group provided in the example of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Embodiments of the device for stimulating the caudate nucleus in the brain to increase the excitability of the nervous system according to the present invention will be described in detail below. As shown in fig. 1 and 4, a schematic structural diagram and a schematic physical structural diagram of an apparatus for stimulating caudate nuclei in brain to improve excitability of a nervous system according to an embodiment of the present invention are provided, and a specific implementation process includes the following steps: an infrared spot frequency light source module (i.e. a high-power infrared spot frequency light source 101), an optical fiber coupling module 102 and a puncture guiding component 103.
In the embodiment of the invention, the infrared spot frequency light source module is used for generating high-power infrared light with the wavelength of 8.5 μm and the optical power of less than or equal to 200 mW. The optical fiber coupling module 102 is configured to perform beam reduction and focusing on the infrared light based on the multi-stage focusing component 201 to obtain focused infrared light, and couple the focused infrared light into the optical fiber 203 for conduction after the focused infrared light is collimated by the collimating component 202. The puncture guide member 103 is configured to guide the front end of the optical fiber 203 to a specific irradiation stimulation site in the brain, and irradiate the infrared light coupled into the optical fiber 203 onto the caudate nucleus in the brain, thereby protecting the front end of the optical fiber 203 from blood, cerebrospinal fluid, and the like of brain tissue. The irradiation stimulation site is a caudate nucleus.
Further, the infrared light is infrared light with repetition frequency less than or equal to 200kHz and pulse width less than or equal to 2 mu s. When the repetition frequency of the infrared light is less than or equal to 200kHz and the pulse width is less than or equal to 2 mu s, the infrared light thermal effect is reduced, and meanwhile, high-frequency stimulation is given to deep functional regions of the brain.
As shown in fig. 3, the puncture guide member 103 includes: an inner guide wire 301, an outer sheath 302, and a stationary switch 303.
The inner guide wire 301 is used for puncturing an irradiation stimulation site in the brain; the end of the inner guide wire 301 is provided with a buckle 602 corresponding to the catch 503 of the outer sheath 302, so that the inner guide wire 301 can be buckled with the outer sheath 302 and can be detachably withdrawn from the outer sheath 302 during the puncture process. Specifically, as shown in fig. 6, the inner guide wire 301 is made of hard plastic with the diameter of 0.8-0.9mm and the hardness of 86-90HD, and the front end 601 is sharp and used for puncturing a specific position in the brain. The end of the inner guide wire 301 has a buckle 602 corresponding to the slot 503 of the outer sheath 302, so as to ensure that the inner guide wire 301 and the outer sheath 302 are tightly combined during the puncturing process, and thus, cannot relatively shift. Simultaneously, the inner wire 301 is slightly twisted clockwise to be removably withdrawn from the outer sheath 302.
The outer sheath 302 is used to puncture under the guidance of the inner guidewire 301 to place the irradiation stimulation site, and to guide the optical fiber 203 along the outer sheath 302 to place the irradiation stimulation site after the inner guidewire 301 is withdrawn from the outer sheath 302. Specifically, as shown in fig. 5, the outer sheath 302 has an inner diameter of 1.1mm, an outer diameter of 1.3mm, and a material hardness of 70-80HD, is a medium hard plastic, has a transparent color, is marked with scales 502 (a puncture depth can be observed in real time during puncture, and the puncture precision can be ensured), is flexible (on one hand, the insertion angle of the optical fiber 203 is not biased, on the other hand, the optical fiber can conform to the soft characteristic of the brain tissue, and the brain tissue can be protected to the maximum), and has a smooth front end (the smooth front end can be inserted into the brain for a long time without damaging the brain tissue); the outer sheath 302 is threaded over the inner guidewire 301 to be placed at the stimulation site, and after the outer sheath 302 is secured, the inner guidewire 301 is withdrawn and the optical fiber 203 can be placed along the outer sheath 302 to the stimulation site.
The fixing switch 303 is used to fix the optical fiber 203 in the outer sheath 302 by mechanical pressure after being closed, so that the optical fiber 203 is fixedly embedded into a corresponding depth. As shown in fig. 7, the fixing switch 303 forms a tubular channel 701 in the middle after being turned off for passing and fixing the optical fiber 203, and the inner surface of the tubular channel is made of a soft material, and the optical fiber can pass through the tubular channel to play a fixing role. The hinge 703 can rotate to close the fixing switch, so that the optical fiber is fixed by mechanical pressure after closing, and the fixing switch 303 is provided with a buckle 702 corresponding to a clamping groove 503 on the sheath 302, so that the fixing switch 303 can be buckled with the sheath 302 in the process of fixing the optical fiber 203. Specifically, the fixing switch 303 is used to fix the optical fiber 203 on the sheath 302, so as to ensure that the optical fiber 203 is inserted to a proper depth without being too deep, and also ensure that the optical fiber 203 does not shift during testing, thereby causing damage to brain tissue and damage to the optical fiber 203 itself due to stress. The stationary switch 303 may be repeatedly turned on and off. When closed, a tubular passage is formed in the middle (through which the optical fiber 203 passes). The inner surface of the fixed switch 303 is relatively flexible (can be adapted to the thickness of the optical fiber 203, and does not cause damage to the optical fiber 203 due to mechanical stress). The outer surface of the fixed switch 303 has a buckle 702, which can correspond to a slot 503 of the outer sheath 302 (the slot 503 is also the slot 503 corresponding to the buckle 602 of the inner guide wire 301). Before the puncture operation, the inner guide wire 301 needs to be removed, and the fixed switch 303 is attached to the outer sheath 302 and kept in an open state. Then, the optical fiber 203 is inserted through the sheath 302, and after the insertion depth is matched with the scale marks on the sheath 302, the fixing switch 303 is closed to clamp the optical fiber 203. Finally, the inner guide wire 301 can be reattached by removing the stationary switch 303 along with the optical fiber 203, and the puncturing operation can begin.
As shown in fig. 2, the fiber coupling module 102 includes: the collimating component 202, the multi-stage focusing component 201, and the optical fiber 203. The multistage focusing component 201 is configured to narrow the light spot of the infrared light emitted by the infrared spot frequency light source module, so that the radius of the light spot of the infrared light is reduced to be less than or equal to 600 μm, and then focused infrared light is obtained; the collimating component 202 is configured to collimate the focused infrared light, so that the light beam irradiates along a straight line, thereby reducing light scattering; the optical fiber 203 is used for conducting collimated infrared light. Specifically, the optical fiber 203 is a multimode optical fiber, the inner diameter is 580-610 μm, the outer diameter is 900-1000 μm, and the numerical aperture is 0.3, so that the optical fiber can be used for effectively transmitting a light beam with the wavelength of 8.5 μm, and the output end power of the optical fiber is 35 mW.
According to the invention, through analysis, the high-power infrared light with the specific wavelength of 8.5 microns and the light power intensity of 35mW stimulates the caudate nucleus for 5 minutes, so that the secretion of gamma-aminobutyric acid in the brain can be reduced. The concentration of gamma-aminobutyric acid is reduced to improve the excitability of a biological nervous system, so that in the practical implementation process, the device is set to irradiate the infrared light on the caudate nucleus in the brain for 5min, so that the nervous system excitability of an organism is indirectly controlled through the device, and the phenomena of sleepiness and somnolence caused by brain fatigue are reduced.
During the actual test, 8 SD rats of 8 weeks old were subjected to the relevant test using the device. The specific test process is as follows: randomly selecting 8 SD rats with similar physiological states (such as size, weight and the like) at 8 weeks, and dividing the SD rats into 2 groups. There were 4 animals in each of the control and stimulated groups. The same anesthesia and craniotomy operations are performed on each group of rats, then the rats are fixed on an animal headstock stereotaxic apparatus, then the puncture guide part 103 is positioned and punctured into the caudate nucleus, and the optical fiber 203 is guided through the puncture guide part 103 and fixed at the stimulation point of the caudate nucleus. And finally, adjusting parameters and turning on the high-power dot frequency infrared light source. The stimulation group was given infrared irradiation of 8.5 μm wavelength for 5 min. The control group was inserted with the optical fiber only 2035 min without infrared irradiation. After the process is finished, the skull of the rat is opened, the brain of the rat is taken out, the cerebellum and the brain stem are removed, and the rat is placed into a cryopreservation tube for liquid nitrogen preservation. The brain samples of each rat were analyzed for the concentration of gaba in the rat body by taking the measurement of gaba in the rat body. The test was repeated 3 times as described above, and the γ -aminobutyric acid concentrations of the 3 tests were averaged for statistical analysis, and a γ -aminobutyric acid result histogram (the abscissa is classification of the control group and the stimulation group, and the ordinate is concentration value) as shown in fig. 8 was prepared. The abscissa T is concentration data of a test group stimulated by infrared light, and the abscissa C is concentration data of a control group, and only the optical fiber is inserted but not stimulated; the ordinate represents concentration.
By analyzing the concentration of the gamma-aminobutyric acid, the concentration of the gamma-aminobutyric acid in the brain of the rat is lower than that of a control group without stimulation when the infrared light stimulation is given. In addition, no significant difference in NeuN was found between the test and control groups by western blot testing of neuronal core antigen (NeuN) in murine brain neurons. As shown in FIG. 9, which is a graph showing the results of protein bands of NeuN, T1-4 is a test group stimulated by infrared light, and C1-4 is a control group, to which only optical fibers are inserted but which are not stimulated.
As shown in fig. 10, which is a histogram of NeuN, the abscissa is the classification of the control group and the stimulated group, and the ordinate is the concentration value. The abscissa T is concentration data of a test group stimulated by infrared light, and the abscissa C is concentration data of a control group, and only the optical fiber is inserted but not stimulated; the ordinate represents concentration. The analysis results suggest that the infrared light stimulation does not damage the brain nerve tissue at the molecular level.
According to the test result, the device for stimulating the caudate nucleus in the brain to improve the excitability of the nervous system can reduce the concentration of gamma-aminobutyric acid in the brain to improve the excitability of the nervous system and relieve the phenomena of drowsiness and somnolence caused by brain fatigue based on the stimulation effect of infrared light on the biological nerve, and meanwhile, the infrared light stimulation does not damage the cranial nerve of the mouse, so that the device is safe and reliable.
The front end of the puncture positioning part is arranged at the central position of the rat brain caudate nucleus; the infrared spot frequency light source module generates infrared light, the infrared light passes through the optical fiber 203 and the sheath 302 and then accurately irradiates on the caudate nucleus, and the problems of fatigue, drowsiness and the like caused by central nervous system inhibition caused by excessive secretion of gamma-aminobutyric acid can be efficiently, quickly and low in side effect.
The infrared light is introduced into the brain, and the caudate nucleus of the brain is stimulated, so that the secretion of gamma-aminobutyric acid in the brain can be reduced, the inhibition state of the central nervous system of the brain of a human is further improved, the brain fatigue is relieved, and the excitability of the nervous system is improved. The device has the innovation points that the central nervous system cannot be damaged, only a micro wound is brought to an individual when the device is used, the device is safe and reliable, and the wound is easy to heal after operation; the device has the advantages of simple operation, high safety, no side effect, timeliness and short treatment time.
According to the device for stimulating the caudate nucleus in the brain to improve the excitability of the nervous system, the infrared dot frequency light source module generates high-power infrared light with the wavelength of 8.5 microns and the luminous power of 35 mW; the optical fiber coupling module is used for reducing infrared light and focusing light beams based on a multi-stage focusing component to obtain focused infrared light, and the focused infrared light is collimated by a collimating component and then coupled into an optical fiber for conduction; the puncture guiding component is used for guiding the front end of the optical fiber to a specific irradiation stimulation site in the brain, infrared light coupled into the optical fiber is irradiated on caudate nuclei in the brain, the caudate nuclei in the brain can be stimulated by the infrared light to reduce nervous system inhibition and fatigue feeling caused by excessive secretion of gamma-aminobutyric acid in the brain, the nervous system excitation degree of an organism is controlled indirectly, and the puncture guiding component is simple to operate, safe, reliable, rapid in regulation and control and short in time.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. An apparatus for stimulating the caudate nucleus in the brain to increase nervous system excitability, comprising:
the infrared spot frequency light source module is used for generating high-power infrared light with the wavelength of 8.5 microns and the optical power of less than or equal to 200 mW;
the optical fiber coupling module is used for reducing and focusing the infrared light based on the multi-stage focusing component to obtain focused infrared light, and then the focused infrared light is collimated by the collimating component and then coupled into an optical fiber for conduction;
a puncture guide member for guiding the tip of the optical fiber to a specific irradiation stimulation site in the brain and irradiating the infrared light coupled into the optical fiber onto the caudate nucleus in the brain; wherein the irradiation stimulation site is caudate nucleus.
2. The device for stimulating the caudate nucleus within the brain to increase nervous system excitability of claim 1, wherein the puncture guide member comprises: an inner guide wire, an outer sheath and a fixed switch;
the inner guide wire is used for puncturing an irradiation stimulation site entering the brain; the tail end of the inner guide wire is provided with a buckle corresponding to the clamping groove of the outer sheath, so that the inner guide wire can be buckled with the outer sheath and can be detachably withdrawn from the outer sheath in the puncture process;
the outer sheath is used for puncturing and placing the irradiation stimulation site under the guidance of the inner guide wire, and guiding the optical fiber to be placed into the irradiation stimulation site along the outer sheath after the inner guide wire is withdrawn from the outer sheath;
the fixing switch is used for fixing the optical fiber in the sheath through mechanical pressure after being closed, so that the optical fiber is fixedly arranged at a corresponding depth.
3. The apparatus of claim 2, wherein the switch forms a tubular channel for passing and fixing the optical fiber in the middle after being closed, and the inner surface of the tubular channel is made of soft material to protect the optical fiber from being damaged by mechanical pressure.
4. The apparatus of claim 2, wherein the switch is provided with a snap corresponding to a snap on the sheath to allow the switch to be engaged with and disengaged from the sheath during the process of fixing the optical fiber.
5. The device of claim 2, wherein the outer sheath has an inner diameter of 1.1mm and an outer diameter of 1.3 mm; the sheath is made of 70-80HD materials, is transparent in color and is provided with scales on the surface.
6. The device for stimulating the caudate nucleus within the brain to increase nervous system excitability of claim 2, wherein the inner guide wire is 0.8-0.9mm in diameter; the hardness of the material of the inner guide wire is 86-90 HD.
7. The apparatus of claim 1, wherein the fiber coupling module comprises: the multi-stage focusing assembly, the collimating assembly and the optical fiber;
the multistage focusing component is used for reducing the light spot of the infrared light emitted by the infrared spot frequency light source module to enable the radius of the light spot of the infrared light to be reduced to be less than or equal to 600 micrometers, and then the focused infrared light is obtained; the collimation component is used for collimating the focused infrared light so that the light beam irradiates along a straight line; the optical fiber is used for conducting the collimated infrared light.
8. The device as claimed in claim 7, wherein the optical fiber is a multimode optical fiber with an inner diameter of 580-610 μm, an outer diameter of 900-1000 μm and a numerical aperture of 0.3, and is used to effectively conduct a light beam with a wavelength of 8.5 μm, so that the power of the exit end of the optical fiber is 35 mW.
9. The apparatus of claim 1, wherein the infrared light has a repetition frequency of 200kHz or less and a pulse width of 2 μ s or less.
10. The device of claim 1, wherein the device is configured to irradiate the infrared light on the caudate nucleus within the brain for a period of 5 min.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| FR3147496A1 (en) * | 2023-04-05 | 2024-10-11 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Device for fixing an optical probe for intracerebral stimulation |
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