CN115089851A

CN115089851A - Artificial cochlea implant capable of continuously feeding medicine

Info

Publication number: CN115089851A
Application number: CN202210704239.1A
Authority: CN
Inventors: 孙增军; 许车明; 王澄; 刘新东; 张育恒; 龙玲
Original assignee: Shanghai Listent Medical Tech Co ltd
Current assignee: Shanghai Listent Medical Tech Co ltd
Priority date: 2022-06-21
Filing date: 2022-06-21
Publication date: 2022-09-23

Abstract

The invention provides a cochlear implant capable of continuously feeding medicine, which comprises: an electrode array and a drug delivery assembly comprised of a plurality of electrode contacts; the drug delivery assembly comprises a drug storage bag and a drug delivery pipe, and the drug storage bag is elastic; the tail end of the administration tube is connected with the electrode array back to back; the drug storage bag is contracted to deliver the drug into the cochlea through the drug delivery pipe. The artificial cochlea implant capable of continuously feeding the drug has the advantages of simple overall structure and convenient use, and can continuously and uniformly feed the drug into the scala tympani of the cochlea for a long time, thereby achieving the effect of long-term treatment and being beneficial to promoting the hearing recovery of a patient.

Description

Artificial cochlea implant capable of continuously feeding medicine

Technical Field

The invention relates to the field of otology medical appliances, in particular to a cochlear implant capable of continuously feeding medicine.

Background

The artificial cochlea is the only effective method and device which are generally recognized in the world at present and can restore the auditory sense of patients with bilateral severe or extremely severe sensorineural deafness. The product is based on biomedicine, integrates multiple disciplines and multiple technologies such as linguistics, electronics, chemistry, bionics, signal processing technology, large-scale integrated circuit technology, precision machining technology and the like, and enables deaf patients to return to the audio world through interdisciplinary high-tech combination. The artificial cochlea implants the multi-channel electrode into the scala tympani of the ear cochlea through an operation, the sound processor is worn outside the human body to send a coded sound signal to the implanted body, and the implanted body is decoded and then stimulates auditory neurons by the electrode implanted into the scala tympani, so that the auditory sense is generated. In the conventional cochlear implant, there are many problems. Firstly, in the process of electrode implantation surgery, although a soft and small thin electrode design and a minimally invasive surgery are adopted, the injury of the electrode to cochlear tissues is inevitably generated, and inflammatory reaction is caused; secondly, because the implanted electrode is a cochlear tissue foreign material, connective tissues can grow around the electrode along with the time of implantation, the electrode impedance is increased, and the electrical stimulation effect of the electrode is influenced.

Recent studies have demonstrated that the continuous administration of glucocorticoids to the inner ear is effective in treating a variety of diseases of the inner ear.

In the prior art, drug delivery is mainly carried out in a mode of carrying drug on a coating on the surface of an electrode and carrying drug on a silica gel matrix, and the drug delivery is disposable, so that the quantity of the drugs is limited, and the effect of long-term treatment cannot be achieved. Some medicines are stored in the medicine bag, and long-term administration is realized through injection, but the medicine can be sent into the cochlea scala tympani only by providing medicine discharge pressure of the medicine bag by means of a tool, and the medicine discharge condition in the medicine bag cannot be monitored, so that the deafness patient can be reminded of administration in time.

In view of the above, the present invention is particularly proposed.

Disclosure of Invention

The invention aims to provide a cochlear implant capable of continuously and evenly feeding medicine into the scala tympani of a cochlea for a long time when a cochlear implant normally works, so that the cochlear implant can achieve the effect of long-term treatment and is beneficial to promoting the hearing recovery of a patient; through setting up elastic medicine storage bag, can utilize the contraction pressure output medicine of medicine storage bag self to need not with the help of the instrument, simplified holistic structure.

In order to achieve the above purpose of the present invention, the following technical solutions are adopted:

the invention provides a cochlear implant capable of continuously feeding medicine, which comprises: an electrode array and a drug delivery assembly comprised of a plurality of electrode contacts;

the drug delivery assembly comprises a drug storage bag and a drug delivery pipe, and the drug storage bag is elastic; the tail end of the administration tube is connected with the electrode array back to back; the drug storage bag contracts to deliver the drug into the cochlea through the drug delivery pipe.

In the prior art, the following problems mainly exist in the treatment and administration in the ear:

1. the administration is mainly carried out in a mode of carrying medicine by a coating on the surface of the electrode and carrying medicine by a silica gel matrix, and is disposable, so that the medicine quantity is limited, and the effect of long-term treatment cannot be achieved;

2. some medicines are stored in the medicine bag and are taken for a long time through injection, but the medicines can be sent into the cochlea scala tympani only by providing medicine discharge pressure of the medicine bag with the help of a tool, the structure is complex, the use is inconvenient, and the cost is high.

In order to solve the technical problems, the invention provides the cochlear implant capable of continuously feeding medicine, the cochlear implant can output medicine by utilizing the self contraction pressure of the medicine storage bag by arranging the elastic medicine storage bag, is convenient to use and can automatically and uninterruptedly feed medicine without tools; and the medicine storage bag can store a large amount of medicines, so that long-term continuous and balanced administration into the scala tympani of the cochlea is facilitated, the effect of long-term treatment can be achieved, and the hearing recovery of a patient is facilitated.

Preferably, a control valve for controlling the dosage is arranged between the medicine storage bag and the administration tube; the control valve comprises a piston cylinder and a piston; a drug delivery channel is arranged in the center of the piston cylinder, an inlet of the drug delivery channel is communicated with the drug storage bag, and an outlet of the drug delivery channel is communicated with the drug delivery pipe; an annular sliding cavity is formed between the dosing channel and the side wall of the piston cylinder; the piston slides in the sliding cavity to control the amount of medicine entering the medicine feeding channel. Through setting up the control valve, can control the dose of infusing, guarantee the balanced medicine that advances.

Preferably, the piston comprises a sliding part and a sealing part, the sliding part is fixedly connected with the sealing part, and two arc-shaped notches are formed between the sliding part and the sealing part; the sliding part is positioned in the sliding cavity; and a sealing plug matched with the inlet of the administration channel is arranged on one side of the sealing part close to the sliding part. Further, the inlet of the administration channel is tapered. The distance between the sealing plug and the inlet of the drug feeding channel can be adjusted by moving the position of the sliding part, so that the size of the drug feeding port is adjusted. In fact, the piston is integrally similar to a bottle cap structure, and when the medicine storage bag is used, liquid medicine in the medicine storage bag enters the medicine feeding pipe through the notch and the inlet of the medicine feeding channel and is fed into ears through the medicine feeding pipe.

Preferably, a partition plate and a spring are arranged in the sliding cavity, one end of the spring is connected with the partition plate, and the other end of the spring is connected with the sliding part. By providing the partition plate and the spring, the movement of the sliding portion in the sliding chamber can be controlled by the elastic force of the spring. In the medicine discharging process of the medicine storage bag, along with medicine output, the contraction force of the medicine storage bag is slowly reduced, the piston slowly moves under the action of the spring force and the contraction force of the medicine storage bag in order to achieve a force balance state, the medicine inlet is slowly enlarged, so that the medicines in the medicine storage bag are controlled to be output through the control valve in a balanced mode, and the purpose of long-time continuous and balanced medicine feeding is achieved.

Preferably, one side of the partition plate, which is far away from the spring, is provided with a pressure sensor, the pressure sensor is connected with a control circuit, and the control circuit is connected with a monitor. Furthermore, the monitoring instrument is arranged outside the body and is connected with the control circuit through Bluetooth, and a battery used for supplying power is arranged in the control circuit. The monitor is arranged to monitor the medicine condition in the medicine storage bag. When the contractility of the medicine storage bag is reduced to the state that the medicine can not be output, the pressure sensor senses the pressure change and transmits the pressure change to the monitoring instrument through the control circuit, thereby timely reminding the deaf patient to administer the medicine.

Preferably, a buckle plate is arranged at the opening of the piston cylinder, a hole is formed in the center of the buckle plate, and the diameter of the hole is smaller than the outer diameter of the sliding part. The buckle can adopt sticky mode to be connected with the piston cylinder, sets up the buckle and can play limiting displacement to the sliding part to prevent that the sliding part from following the sliding chamber roll-off under the effect of spring force.

Preferably, the side wall of the sliding cavity is provided with a vent hole, and the vent hole is connected with a vent pipe. This is provided to balance the pressure and facilitate the sliding of the sliding portion in the sliding chamber.

Preferably, the end of the administration tube is provided with a plurality of administration holes, and the medicament is injected into the cochlea through the administration holes; preferably, a plurality of the administration holes are arranged in a comb shape, a fishbone shape or a barbed shape; the fishbone-shaped arrays can also be arranged in a staggered mode, the barbed array is characterized in that the outlet direction of the drug delivery holes at the proximal ends of the electrodes faces backwards, the outlet direction of the drug delivery holes at the distal ends of the electrodes faces forwards and outwards, all the arrays can also be combined, and the arrangement mode is not limited to the above. Preferably, the administration hole is funnel-shaped; preferably, the administration hole is a through hole or a thin-wall blind hole. In practical use, the administration mode can be directly through the through hole or through thin-wall blind hole thin-wall leakage, and when the administration mode is a thin-wall blind hole, the thickness of the thin wall can be controlled to be several micrometers.

Preferably, an injection seat is arranged on the medicine storage bag, and the injection seat is connected with an injection assembly for supplementing medicine into the medicine storage bag. In actual setting, the injection seat is arranged on one side of the medicine storage bag, which is far away from the control valve.

Preferably, the injection assembly comprises a syringe, and a needle is mounted at the front end of the syringe and penetrates through the injection seat to enter the medicine storage bag. When the medicine in the medicine storage bag is insufficient, the needle of the injector is inserted into the medicine storage bag, the end part of the needle extrudes the piston to enable the sealing plug to seal the inlet of the administration channel, and then a certain amount of medicine is injected into the medicine storage bag. The drug injection can be selected from various drugs, such as dexamethasone and neurotrophic factor. When the medicine is injected, the dosage and time can be controlled by an external micro-flow control pump and an injection needle and an external control pump.

Preferably, a one-way valve is arranged in the administration tube. The one-way valve is disposed proximate the electrode array. This arrangement prevents backflow of lymph within the cochlea.

Preferably, the implant further comprises a receiving coil, a decoding stimulator and an electrode lead, wherein the receiving coil is connected with the decoding stimulator, and the decoding stimulator transmits an electrical stimulation signal to the electrode array through the electrode lead. When the device is actually used, the receiving coil receives a coded sound signal sent by an external sound processor, the coded sound signal is decoded by the decoding stimulator to generate an electric stimulation signal, and the electric stimulation signal is transmitted to an electrode array implanted in a cochlea and connected with auditory neurons through a connected electrode lead to stimulate the auditory neurons to generate auditory sense. The receiving coil and the electrode lead are generally made of platinum wires or platinum iridium wires, the outer layer of the platinum iridium wires is coated with insulating materials, the decoding stimulator comprises a power supply circuit, a decoding circuit, a feedback circuit and a constant current source circuit, and the electrode array generally consists of a plurality of electric stimulation electrodes and is generally made of platinum sheets or platinum rings.

Preferably, the administration tube is made of a biocompatible material such as silicone.

Compared with the prior art, the invention has the beneficial effects that:

the artificial cochlea implant body capable of continuously feeding the medicine has simple integral structure and convenient use, does not need additional tools, and provides medicine discharging power through the self contraction pressure of the medicine storage bag. In the medicine discharging process of the medicine storage bag, along with medicine output, the contraction force of the medicine storage bag is slowly reduced, the piston of the control valve slowly moves under the action of spring force and the contraction force of the medicine storage bag in order to achieve a force balance state, the medicine inlet is slowly enlarged, so that medicine in the medicine storage bag is controlled to be output in a balanced mode through the control valve, and the purpose of long-time continuous and balanced medicine feeding is achieved by combining multiple times of medicine injection. When the contractility of the medicine storage bag is reduced to the state that the medicine can not be output, the monitor monitors the medicine condition of the medicine storage bag at any time and reminds the deaf patient to administer the medicine in time, thereby ensuring the continuity of treatment.

Drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to refer to like parts throughout the drawings. In the drawings:

fig. 1 is a schematic structural diagram of an overall cochlear implant capable of continuously administering drugs according to an embodiment of the present invention;

FIG. 2 is a schematic structural diagram of a control valve according to an embodiment of the present invention;

FIG. 3 is a schematic structural diagram of a piston cylinder provided in an embodiment of the invention;

FIG. 4 is a schematic structural diagram of a piston according to an embodiment of the present invention;

FIG. 5 is a schematic cross-sectional view A-A of FIG. 4;

FIG. 6 is a schematic structural diagram of a drug injection into a reservoir according to an embodiment of the present invention;

FIG. 7 is a schematic view of a reservoir for dispensing medication according to an embodiment of the present invention;

FIG. 8 is a schematic view of a comb-like arrangement of drug delivery holes according to an embodiment of the present invention;

FIG. 9 is a schematic view of a fishbone arrangement of administration holes according to an embodiment of the invention;

FIG. 10 is a schematic view of a configuration of a drug delivery hole in a barbed arrangement according to an embodiment of the present invention;

fig. 11 is a schematic structural view of a drug delivery tube according to an embodiment of the present invention for drug delivery by a thin-wall leakage method.

Wherein:

10-a receiving coil; 20-decoding the stimulator;

30-a medicine storage bag; 40-a control valve;

401-a sliding cavity; 402-a drug delivery channel;

403-a control circuit; 404-a pressure sensor;

405-a separator; 406-a spring;

407-a vent hole; 408-a pinch plate;

50-an administration tube; 60-a one-way valve;

70-a monitor; 80-a syringe;

90-needle head; 100-a breather pipe;

110-an injection seat; 120-a piston;

1201-sealing part; 1202-a sliding part;

1203-notches; 1204-a sealing plug;

130-an administration aperture; 140-electrode lead;

150-electrode array.

Detailed Description

The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings and the detailed description, but those skilled in the art will understand that the following described embodiments are some, not all, of the embodiments of the present invention, and are only used for illustrating the present invention, and should not be construed as limiting the scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

In order to more clearly illustrate the technical solution of the present invention, the following description is made in the form of specific embodiments.

Examples

Referring to fig. 1 to 11, the present embodiment provides a cochlear implant capable of sustained drug delivery, comprising: an electrode array 150 consisting of a plurality of electrode contacts, a receiving coil 10, a decoding stimulator 20, an electrode lead 140 and a drug delivery assembly; the receive coil 10 is connected to a decode stimulator 20, and the decode stimulator 20 delivers electrical stimulation signals to an electrode array 150 via electrode leads 140. In practical use, the receiving coil 10 receives the coded sound signal emitted by the external sound processor, the coded sound signal is decoded by the decoding stimulator 20 to generate an electrical stimulation signal, and the electrical stimulation signal is transmitted to the electrode array 150 implanted in the cochlea and connected with the auditory neurons through the connected electrode lead 140 to stimulate the auditory neurons to generate auditory sense. The receiving coil 10 and the electrode lead 140 are made of platinum wire or platinum iridium wire, the outer layer of the platinum iridium wire is coated with insulating material, the decoding stimulator 20 comprises a power supply circuit, a decoding circuit, a feedback circuit and a constant current source circuit, and the electrode array 150 is composed of a plurality of electrical stimulation electrodes, and is generally made of platinum sheet or platinum ring.

As shown in fig. 2, the administration set comprises a medicine storage bag 30 and an administration tube 50, the medicine storage bag 30 having elasticity; the end of the administration tube 50 is connected back-to-back with the electrode array 150; drug reservoir 30 is deflated to deliver the medicament into the cochlea through administration tube 50. A check valve 60 is provided in the administration tube 50. A one-way valve 60 is disposed proximate to the electrode array 150.

Wherein a control valve 40 for controlling the dosage is arranged between the medicine storage bag 30 and the administration tube 50; the control valve 40 includes a piston cylinder and piston 120; the piston cylinder structure is shown in figure 3. The center of the piston cylinder is provided with a dosing channel 402, the inlet of the dosing channel 402 is communicated with the medicine storage bag 30, and the outlet is communicated with the dosing pipe 50; an annular sliding cavity 401 is formed between the dosing channel 402 and the side wall of the piston cylinder; the piston 120 slides within the sliding chamber 401 to control the amount of drug entering the administration channel 402. The side wall of the sliding cavity 401 is provided with a vent 407, and the vent 407 is connected with a vent pipe 100.

As shown in fig. 4-5, the piston 120 includes a sliding portion 1202 and a sealing portion 1201, the sliding portion 1202 is fixedly connected to the sealing portion 1201, and two arc-shaped notches 1203 are disposed between the sliding portion 1202 and the sealing portion 1201; the sliding part 1202 is located in the sliding cavity 401; the sealing part 1201 is provided with a sealing plug 1204 adjacent to the sliding part 1202, which is adapted to the inlet of the administering channel 402. In this embodiment, the inlet of the administration channel 402 is tapered. In fact, the piston 120 is integrally formed like a bottle cap, and when in use, the liquid medicine in the medicine storage bag 30 enters the administration passage 402 through the notch 1203 and the inlet of the administration passage 402, and is administered into the ear through the administration passage 402. The distance between the sealing plug 1204 and the inlet of the administration channel 402 can be adjusted by moving the position of the sliding part 1202, thereby adjusting the size of the medicine inlet.

In order to prevent the sliding part 1202 of the piston 120 from separating from the sliding cavity 401, a buckle plate 408 is arranged at the cylinder opening of the piston cylinder, the center of the buckle plate 408 is provided with a hole, and the diameter of the hole is smaller than the outer diameter of the sliding part 1202. The pinch plate 408 can be connected with the piston cylinder by gluing or can be arranged at the cylinder opening of the piston cylinder by adopting a threaded connection mode.

With continued reference to fig. 2, a diaphragm 405 and a spring 406 are disposed within the sliding chamber 401, with one end of the spring 406 being connected to the diaphragm 405 and the other end being connected to the sliding portion 1202. The side of the diaphragm 405 away from the spring 406 is provided with a pressure sensor 404, the pressure sensor 404 is connected with a control circuit 403, and the control circuit 403 is connected with the monitor 70. The monitor 70 is arranged outside the body and connected with the control circuit 403 through Bluetooth, and a battery for supplying power is arranged in the control circuit 403. When the drug storage bag 30 is used, when the contractile force of the drug storage bag 30 is reduced to a level that the drug cannot be output, the pressure sensor 404 senses the pressure change and transmits the pressure change to the monitoring instrument 70 through the control circuit 403, so that the deaf patient is reminded of supplementing the drug in time.

In actual administration, administration may be performed by providing the administration hole 130 at the end of the administration tube 50, or administration may be performed directly by thin-wall leakage.

When the administration hole 130 is used for administration, as shown in fig. 8 to 10, the distal end of the administration tube 50 is provided with a plurality of administration holes 130, and the agent is injected into the cochlea through the administration holes 130; the plurality of administration holes 130 are arranged in a comb shape, a fishbone shape or a barbed shape; the fishbone-shaped array may be a staggered array, or a barbed array characterized in that the outlet direction of the electrode proximal administration hole 130 is oriented rearward, and the outlet direction of the electrode distal administration hole 130 is oriented forward and outward, or any combination of these arrangements, and the arrangement is not limited thereto. The drug delivery hole 130 is funnel-shaped and can be a through hole or a thin-wall blind hole.

When the thin-wall leakage mode is used for the administration, as shown in FIG. 11, the thickness of the thin wall is controlled to be several μm.

In this embodiment, the drug is administered by means of the administration holes 130, and the administration holes 130 are arranged in a comb-like manner.

As shown in fig. 6, the medicine cartridge 30 is provided with an injection seat 110, and an injection assembly for replenishing medicine into the medicine cartridge 30 is connected to the injection seat 110. In practice, the injection seat 110 is arranged on the side of the cartridge 30 remote from the control valve 40.

Specifically, the injection assembly includes a syringe 80 having a needle 90 mounted to the forward end of the syringe 80, the needle 90 passing through an injection seat 110 into the drug reservoir 30. When the medicine in the medicine storage bag 30 is insufficient, the needle 90 of the syringe 80 is inserted into the medicine storage bag 30, the piston 120 is pressed by the end of the needle 90 to seal the inlet of the administration passage 402 with the sealing plug 1204, and then a certain amount of medicine is injected into the medicine storage bag 30. The drug injection can be selected from various drugs, such as dexamethasone and neurotrophic factor. When the medicine is injected, the dosage and time can be controlled by an in-vitro micro-flow control pump and an injection needle and an in-vitro control pump.

In this embodiment, the administration tube 50 and the ventilation tube 100 are made of biocompatible materials, specifically, silica gel.

The principle of administration of the implant of this example is as follows: when the medicine storage bag is used, a certain amount of medicine is injected into the medicine storage bag 30, the size of the medicine storage bag 30 is increased through the injected medicine, and the medicine is sent into a cochlea by the medicine delivery pipe 50 through the medicine storage bag 30 under the action of the self-contraction force. In the process of discharging the medicine from the medicine storage bag 30, along with the medicine output, the contraction force of the medicine storage bag 30 is slowly reduced, and the flow rate of the medicine is reduced; in order to achieve the force balance state, the piston 120 slowly moves under the action of the force of the spring 406 and the contraction force of the medicine storage bag 30, at the moment, the distance between the sealing plug 1204 and the inlet of the medicine feeding channel 402 is increased, the medicine inlet is slowly enlarged, and then the medicines in the medicine storage bag 30 are controlled to be output in a balanced manner through the control valve 40, so that the aim of continuously and uniformly feeding the medicines for a long time is achieved.

In a word, the artificial cochlea implant body capable of continuously feeding the drug has simple integral structure and convenient use, and can continuously and evenly feed the drug into the scala tympani of the cochlea for a long time, thereby achieving the effect of long-term treatment and being beneficial to promoting the hearing recovery of a patient.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A cochlear implant for sustained drug delivery, comprising: an electrode array and a drug delivery assembly comprised of a plurality of electrode contacts;

the drug delivery assembly comprises a drug storage bag and a drug delivery tube, and the drug storage bag is elastic; the tail end of the administration tube is connected with the electrode array back to back; the drug storage bag is contracted to deliver the drug into the cochlea through the drug delivery pipe.

2. The cochlear implant of claim 1, wherein a control valve for controlling the dose is provided between the drug storage capsule and the administration tube; the control valve comprises a piston cylinder and a piston; a dosing channel is arranged in the center of the piston cylinder, an inlet of the dosing channel is communicated with the medicine storage bag, and an outlet of the dosing channel is communicated with the dosing pipe; an annular sliding cavity is formed between the dosing channel and the side wall of the piston cylinder; the piston slides in the sliding cavity to control the amount of medicine entering the medicine feeding channel.

3. The cochlear implant of claim 2, wherein the piston comprises a sliding portion and a sealing portion, the sliding portion is fixedly connected to the sealing portion, and two arc-shaped notches are formed between the sliding portion and the sealing portion; the sliding part is positioned in the sliding cavity; and a sealing plug matched with the inlet of the administration channel is arranged on one side of the sealing part close to the sliding part.

4. The cochlear implant of claim 3, wherein a partition plate and a spring are disposed in the sliding chamber, one end of the spring is connected to the partition plate, and the other end of the spring is connected to the sliding portion.

5. The cochlear implant of claim 4, wherein a pressure sensor is disposed on a side of the diaphragm away from the spring, and the pressure sensor is connected with a control circuit connected with a monitor.

6. The cochlear implant of claim 3, wherein a pinch plate is provided at the mouth of the piston cylinder, and an opening is provided at the center of the pinch plate, and the diameter of the opening is smaller than the outer diameter of the sliding part.

7. The cochlear implant of claim 3, wherein the sliding cavity side wall is provided with a vent hole to which a vent tube is connected.

8. The cochlear implant of claim 1, wherein the distal end of the administration tube is provided with a plurality of administration holes through which the pharmaceutical agent is injected into the cochlea; preferably, a plurality of the administration holes are arranged in a comb shape, a fishbone shape or a barbed shape; preferably, the administration hole is funnel-shaped; preferably, the administration hole is a through hole or a thin-wall blind hole.

9. The cochlear implant of claim 1, wherein the drug storage capsule is provided with an injection seat, and the injection seat is connected with an injection component for supplementing drugs into the drug storage capsule;

preferably, the injection assembly comprises a syringe, and a needle is mounted at the front end of the syringe and penetrates through the injection seat to enter the medicine storage bag.

10. The cochlear implant of claim 1, wherein a one-way valve is disposed within the administration tube.