CN115089807A - Implantable drug delivery system - Google Patents
Implantable drug delivery system Download PDFInfo
- Publication number
- CN115089807A CN115089807A CN202210708278.9A CN202210708278A CN115089807A CN 115089807 A CN115089807 A CN 115089807A CN 202210708278 A CN202210708278 A CN 202210708278A CN 115089807 A CN115089807 A CN 115089807A
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- Prior art keywords
- drug delivery
- cavity
- piston
- medicine
- medicine storage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012377 drug delivery Methods 0.000 title claims abstract description 67
- 239000003814 drug Substances 0.000 claims abstract description 134
- 229940079593 drug Drugs 0.000 claims abstract description 40
- 230000008878 coupling Effects 0.000 claims description 18
- 238000010168 coupling process Methods 0.000 claims description 18
- 238000005859 coupling reaction Methods 0.000 claims description 18
- 238000001727 in vivo Methods 0.000 claims description 18
- 238000007599 discharging Methods 0.000 claims description 9
- 239000007924 injection Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 7
- 230000006698 induction Effects 0.000 claims description 6
- 238000002513 implantation Methods 0.000 abstract description 7
- 238000000338 in vitro Methods 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 8
- 239000007943 implant Substances 0.000 description 5
- 230000009471 action Effects 0.000 description 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229940043263 traditional drug Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3327—Measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
Abstract
The invention discloses an implantable drug delivery system, which comprises an implantation device and an in-vitro control device, wherein the implantation device comprises a micropump, a drug storage module and a drug delivery module, the micropump comprises a pump body provided with a piston cavity, a piston and a spring, the piston divides the piston cavity into a device cavity and a drug delivery cavity, the pump body is also provided with a vent hole, a drug inlet hole and a drug delivery hole, and a magnetic sheet is arranged in the piston; the medicine storage module comprises a medicine storage bag, a medicine storage conduit and a medicine storage one-way valve; the drug delivery module comprises a drug delivery catheter and a drug delivery one-way valve, wherein the drug delivery catheter is provided with a drug outlet hole; the external control device comprises a shell, an external control circuit, a power module and an electromagnetic coil. This implanted drug delivery system makes the implantation device also can carry out the operation of dosing through the magnetic field effort of solenoid to the magnetic sheet need not self-contained power, and the process of dosing is simple swift, and the dose of dosing is controllable, because directly administer in the focus position, can reduce the dose, improve the drug utilization rate.
Description
Technical Field
The present invention relates to a drug delivery system, and more particularly to an implantable drug delivery system.
Background
In the aspects of insulin administration, tumor treatment, cardiovascular disease treatment and the like of diabetics, oral medicines and injection medicaments are the most common administration routes, and patients often need hospitalization administration or daily hospital-to-hospital injection, so that much inconvenience is brought to the patients. Meanwhile, the medicine is administrated systemically no matter orally or by injection, the utilization rate of the medicine is low, and side effects are easily caused.
Compared with the traditional drug delivery mode, new drug delivery systems are continuously developed, such as implantable drug delivery systems, which are a type of controlled release systems implanted under the skin or other target sites through operations. Advantages of the implantable drug delivery system: the epidermal absorption disorder and the gastrointestinal degradation do not exist; the medicine directly acts on the target part, so that the side effect on other tissues in the body can be avoided, the blood concentration or the medicine concentration at the target part can be stably controlled for a long time, and a good treatment effect is achieved. However, the existing implantable drug delivery systems also have significant disadvantages: the medicine storage bag is implanted subcutaneously, the micro battery is used for supplying power, the micro pump is used for controlling the medicine amount, and the micro battery cannot supply power for a long time, so that the wireless charging mode is adopted in the technology, the implanted device is complicated, the structure of the implanted micro pump is complex, the cost of the whole system is high, and the like.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, the present invention is directed to an implantable drug delivery system, wherein the implantable device does not require a self-contained power source.
In order to achieve the above object, the present invention provides an implantable drug delivery system, which comprises an implantation device and an in vitro control device, wherein the implantation device comprises a micropump, a drug storage module, and a drug delivery module, the micropump comprises a pump body, a piston, and a spring, the pump body is provided with a piston cavity, the piston is disposed in the piston cavity to divide the piston cavity into a device cavity and a drug delivery cavity, the pump body is further provided with a vent hole, a drug inlet hole, and a drug delivery hole, the vent hole is communicated with the device cavity, the drug inlet hole and the drug delivery hole are respectively communicated with the drug delivery cavity, the spring is disposed in the device cavity to abut against the piston, and a magnetic sheet is disposed in the piston; the medicine storage module comprises a medicine storage bag, a medicine storage catheter and a medicine storage one-way valve, wherein the medicine storage bag is provided with a medicine storage cavity and an injection seat, one end of the medicine storage catheter is communicated with the medicine storage cavity, and the other end of the medicine storage catheter is communicated with the medicine inlet hole; the drug delivery module comprises a drug delivery catheter and a drug delivery one-way valve, the drug delivery catheter is provided with a flow guide section and a drug outlet section which are connected, one end of the flow guide section is communicated with the drug delivery hole, and the drug outlet section is provided with a drug outlet hole; the external control device comprises a shell, an external control circuit, a power module and an electromagnetic coil, wherein the external control circuit and the electromagnetic coil are arranged in the shell.
The micropump also comprises an in-vivo control circuit and an in-vivo coupling coil, wherein the in-vivo control circuit and the in-vivo coupling coil are both arranged in the device cavity; the external control device also comprises an external coupling coil which is arranged at the outer ring position of the electromagnetic coil and is coupled with the internal coupling coil. Further, the micropump further comprises a pressure sensor disposed within the device cavity and electrically connected to the in vivo control circuit.
The external control device also comprises a magnetic induction sensor which is arranged in the shell and electrically connected with the external control circuit.
The drug delivery catheter is provided with a plurality of drug discharge sections.
The end of the medicine discharging section is flat.
The medicine outlet hole is arranged on the section surface of the medicine outlet section.
The implanted drug delivery system can also carry out drug delivery operation under the condition of not needing a self-contained power supply by the magnetic field acting force of the electromagnetic coil to the magnetic sheet, has simple and quick drug delivery process and controllable drug delivery time and dose program, and can reduce the dose, reduce the side effect and improve the drug utilization rate because the drug is directly delivered to the focus part.
The conception, specific structure and technical effects of the present invention will be further described in conjunction with the accompanying drawings to fully understand the purpose, characteristics and effects of the present invention.
Drawings
Fig. 1 is a schematic diagram of the operation of an implantable drug delivery system of the present invention.
Fig. 2 is a schematic view of an implantable drug delivery system of the present invention.
FIG. 3 is a schematic view of a pump body and piston.
Figure 4 is a schematic view of a drug delivery catheter.
Fig. 5 is a schematic view of the medicine outlet hole arranged on the section surface of the medicine outlet section.
FIG. 6 is a schematic view of a drug delivery catheter having a plurality of drug discharge segments.
Fig. 7 is a schematic view of the medicine discharging section being a fan shape.
Detailed Description
The invention is further elucidated with reference to the drawing.
As shown in fig. 1 and 2, the present invention provides an implantable drug delivery system, which includes an implant device 1 and an extracorporeal control device 2, wherein the implant device 1 is disposed in the body and has no self-contained power source, and the extracorporeal control device 2 provides power to the implant device 1 and controls the implant device 1 to perform drug delivery operation.
The implantation device 1 comprises a micro pump 11, a drug storage module 12 and a drug delivery module 13, wherein the drug storage module 12 stores a drug, and the micro pump 11 delivers the drug to a focus part through the drug delivery module 13 after the drug is pumped from the drug storage module 12, so as to achieve the purpose of drug delivery.
The micro pump 11 comprises a pump body 111, a piston 112, a spring 113, an in-vivo control circuit 114, a pressure sensor 115, and an in-vivo coupling coil 116, wherein the pump body 111 is provided with a piston cavity, as shown in fig. 3, the piston 112 is disposed in the piston cavity, dividing the piston cavity into two parts: the pump body 111 further has a vent hole 1113, a drug inlet hole 1114 and a drug outlet hole 1115 to facilitate the piston 112 moving in the piston cavity, the vent hole 1113 is communicated with the device cavity 1111, the drug inlet hole 1114 and the drug outlet hole 1115 are respectively communicated with the drug outlet cavity 1112, the spring 113, the in-vivo control circuit 114, the pressure sensor 115 and the in-vivo coupling coil 116 are all disposed in the device cavity 1111, the pressure sensor 115 and the in-vivo coupling coil 116 are all electrically connected with the in-vivo control circuit 114, the spring 113 abuts against the piston 112, so that the initial state of the piston 112 is located at the right side of the piston cavity, preferably, the piston 112 is located at the rightmost side of the piston cavity, and a magnet sheet 1121 is disposed in the piston 112.
The medicine storage module 12 comprises a medicine storage bag 121, a medicine storage conduit 122 and a medicine storage one-way valve 123, wherein the medicine storage bag 121 is provided with a medicine storage cavity 1211 and an injection seat 1212, the medicine storage cavity 1211 is used for storing medicine, when the medicine storage cavity 1211 needs to be filled with the medicine, a syringe needle passes through the injection seat 1212 to enter the medicine storage cavity 1211 for filling the medicine, the medicine filling amount and time can be controlled by an in vitro micro-flow control pump during filling, one end of the medicine storage conduit 122 is communicated with the medicine storage cavity 1211, the other end is communicated with the medicine inlet 1114, the medicine storage one-way valve 123 is positioned at two ends or in the medicine storage conduit 122, preferably, the medicine storage one-way valve 123 is positioned in the medicine storage conduit 122 near one end of the medicine inlet 1114, so that the medicine can only enter the medicine feeding cavity 1112 from the medicine storage cavity 1211 in one way, and can not flow back into the medicine storage cavity 1211 from the medicine feeding cavity 1112.
The administration module 13 comprises an administration line 131 and an administration one-way valve 132, wherein, as shown in figure 4, the drug delivery conduit 131 is provided with a flow guiding section 1311 and a drug discharging section 1312, which are connected and can be integrally formed, one end of the flow guide section 1311 is communicated with the medicine feeding hole 1115, the medicine discharging section 1312 is provided with a medicine discharging hole 13121, the drug outlet 13121 may be disposed at the end of the drug outlet 1312 (i.e. point administration), as shown in fig. 5, or on the surface of the drug outlet 1312 (i.e. line administration), the administration check valve 132 is located at or in both ends of the flow guide section 1311, preferably, the administration check valve 132 is located in the flow guide section 1311 near one end of the administration hole 1115, therefore, the medicament can only flow through the diversion section 1311 and the medicament outlet section 1312 from the medicament feeding cavity 1112 in sequence in one direction, and is finally conveyed to the focus part from the medicament outlet 13121, so that the purpose of feeding is achieved, and the body fluid in the focus part is prevented from flowing backwards.
As an alternative embodiment, as shown in fig. 6, the medicine discharging section 1312 may be provided in multiple sections to simultaneously administer medicines to different lesion sites to achieve precise medicine administration at different positions, as shown in fig. 7, the medicine discharging section 1312 may also be shaped like a fan, that is, the end is flat, to achieve the purpose of facial medicine administration, rather than the conventional point medicine administration or linear medicine administration, and is suitable for lesion sites with large areas to achieve the effect of uniform medicine administration.
It should be reminded that all parts of the implant device 1 that are in contact with the human body are made of or coated with a biocompatible material, such as silicone.
As shown in fig. 1 and fig. 2, the extracorporeal control apparatus 2 includes a housing 21, an extracorporeal control circuit 22, a power module 23, an electromagnetic coil 24, an extracorporeal coupling coil 25, and a magnetic induction sensor 26, wherein the power module 23 can be powered by a built-in battery or an external power source, the extracorporeal control circuit 22, the electromagnetic coil 24, the extracorporeal coupling coil 25, and the magnetic induction sensor 26 are all disposed in the housing 21, the power module 23, the electromagnetic coil 24, the extracorporeal coupling coil 25, and the magnetic induction sensor 26 are all electrically connected to the extracorporeal control circuit 22, the electromagnetic coil 24 is configured to generate a magnetic field to interact with the magnetic sheet 1121, so that the piston 112 moves in the piston cavity, the extracorporeal coupling coil 25 is located at an outer ring position of the electromagnetic coil 24, and is coupled to the intracorporeal coupling coil 116 for providing energy and interacting data, the magnetic induction sensor 26 is used for sensing the magnetic field strength variation of the magnetic sheet 1121 so as to correct the current of the electromagnetic coil 24 and adjust the magnetic field strength of the electromagnetic coil 24 to adapt to different distances between the external control device 2 and the implantation device 1 caused by different skin thicknesses.
When the implantable drug delivery system works, the electromagnetic coil 24 generates a magnetic field to generate an interaction force with the magnetic sheet 1121, the piston 112 moves from right to left, the drug delivery cavity 1112 gradually enlarges during the movement, the medicament flows into the drug delivery cavity 1112 from the drug storage cavity 1211, and the medicament is temporarily stored in the drug delivery cavity 1112 due to the effects of the drug storage check valve 123 and the drug delivery check valve 132. When the piston 112 moves to a certain position, the magnetic field of the electromagnetic coil 24 is weakened or disappeared, at this time, under the action of the spring 113, the piston 112 moves from left to right, during the movement, the drug delivery cavity 1112 becomes smaller gradually, due to the action of the drug storage check valve 123 and the drug delivery check valve 132, the drug flows out from the drug delivery cavity 1112 and is delivered to the focus part through the drug outlet 13121, during the reciprocating process of the piston 112, the pressure sensor 115 detects the pressure received by the spring 113 (i.e. the action force transmitted by the piston 112 to the spring 113) and feeds back the data information to the in-vivo control circuit 114 and the in-vivo coupling coil 116 to the in-vitro coupling coil 25, and the in-vitro control circuit 22 changes the current magnitude of the electromagnetic coil 24 to control the piston 112 to reciprocate uniformly to reach a proper drug delivery speed, so that, during the continuous reciprocating motion of the piston 112, the medicament is continuously delivered from the medicament storage cavity 1211 to the focus part through the medicament feeding cavity 1112. In addition, the pressure sensor 115 senses the pressure change when the medicine is extracted from the medicine storage 1211 to feed back whether the medicine needs to be supplemented, and if the medicine cannot be continuously extracted from the medicine storage 1211, the medicine is fed back to the external controller to inform the user of the medicine supplement.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations can be devised by those skilled in the art in light of the above teachings. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.
Claims (7)
1. An implantable drug delivery system, comprising: the micro pump comprises a pump body, a piston and a spring, wherein the pump body is provided with a piston cavity, the piston is arranged in the piston cavity and divides the piston cavity into a device cavity and a dosing cavity, the pump body is also provided with a vent hole, a medicine inlet hole and a dosing hole, the vent hole is communicated with the device cavity, the medicine inlet hole and the dosing hole are respectively communicated with the dosing cavity, the spring is arranged in the device cavity and abuts against the piston, and a magnetic sheet is arranged in the piston; the medicine storage module comprises a medicine storage bag, a medicine storage catheter and a medicine storage one-way valve, wherein the medicine storage bag is provided with a medicine storage cavity and an injection seat, one end of the medicine storage catheter is communicated with the medicine storage cavity, and the other end of the medicine storage catheter is communicated with the medicine inlet hole; the drug delivery module comprises a drug delivery catheter and a drug delivery one-way valve, the drug delivery catheter is provided with a flow guide section and a drug outlet section which are connected, one end of the flow guide section is communicated with the drug delivery hole, and the drug outlet section is provided with a drug outlet hole; the external control device comprises a shell, an external control circuit, a power module and an electromagnetic coil, wherein the external control circuit and the electromagnetic coil are arranged in the shell.
2. The implantable drug delivery system of claim 1, wherein: the micropump also comprises an in-vivo control circuit and an in-vivo coupling coil, wherein the in-vivo control circuit and the in-vivo coupling coil are both arranged in the device cavity; the external control device also comprises an external coupling coil which is arranged at the outer ring position of the electromagnetic coil and is coupled with the internal coupling coil.
3. The implantable drug delivery system of claim 2, wherein: the micropump further includes a pressure sensor disposed within the device cavity and electrically connected to the in vivo control circuit.
4. The implantable drug delivery system of claim 1, wherein: the external control device also comprises a magnetic induction sensor which is arranged in the shell and electrically connected with the external control circuit.
5. The implantable drug delivery system of claim 1, wherein: the drug delivery catheter is provided with a plurality of drug discharging sections.
6. The implantable drug delivery system of claim 1, wherein: the end of the medicine discharging section is flat.
7. The implantable drug delivery system of claim 1, wherein: the medicine outlet hole is arranged on the section surface of the medicine outlet section.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210708278.9A CN115089807A (en) | 2022-06-22 | 2022-06-22 | Implantable drug delivery system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210708278.9A CN115089807A (en) | 2022-06-22 | 2022-06-22 | Implantable drug delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115089807A true CN115089807A (en) | 2022-09-23 |
Family
ID=83293137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210708278.9A Pending CN115089807A (en) | 2022-06-22 | 2022-06-22 | Implantable drug delivery system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115089807A (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5270405A (en) * | 1975-12-09 | 1977-06-11 | Keihin Uoruburo Kk | Liquid pumps |
| WO1981000209A1 (en) * | 1979-07-13 | 1981-02-05 | Univ Minnesota | Magnetically controlled drug infusion system |
| US4487603A (en) * | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| WO1997041799A1 (en) * | 1996-05-05 | 1997-11-13 | Influence Medical Technologies Ltd. | Implantable pump and prosthetic devices |
| WO2002076533A1 (en) * | 2001-03-27 | 2002-10-03 | Alessandro Giannessi | Magnetically operated, subcutaneously implantable drug infusion device |
| WO2014115819A1 (en) * | 2013-01-24 | 2014-07-31 | Lwj株式会社 | Pump |
| US20150290373A1 (en) * | 2014-04-15 | 2015-10-15 | Heartware, Inc. | Transcutaneous energy transfer systems |
| CN205683391U (en) * | 2016-03-07 | 2016-11-16 | 上海理工大学 | Medicine delivery capsule |
| CN109172937A (en) * | 2018-09-21 | 2019-01-11 | 王筱芳 | A kind of oncology built-in type chemicotherapy pump |
| CN111760177A (en) * | 2020-06-16 | 2020-10-13 | 杭州电子科技大学 | Microcapsule injection type magnetic control robot for targeted drug delivery and control method thereof |
-
2022
- 2022-06-22 CN CN202210708278.9A patent/CN115089807A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5270405A (en) * | 1975-12-09 | 1977-06-11 | Keihin Uoruburo Kk | Liquid pumps |
| WO1981000209A1 (en) * | 1979-07-13 | 1981-02-05 | Univ Minnesota | Magnetically controlled drug infusion system |
| US4487603A (en) * | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| WO1997041799A1 (en) * | 1996-05-05 | 1997-11-13 | Influence Medical Technologies Ltd. | Implantable pump and prosthetic devices |
| WO2002076533A1 (en) * | 2001-03-27 | 2002-10-03 | Alessandro Giannessi | Magnetically operated, subcutaneously implantable drug infusion device |
| WO2014115819A1 (en) * | 2013-01-24 | 2014-07-31 | Lwj株式会社 | Pump |
| US20150290373A1 (en) * | 2014-04-15 | 2015-10-15 | Heartware, Inc. | Transcutaneous energy transfer systems |
| CN205683391U (en) * | 2016-03-07 | 2016-11-16 | 上海理工大学 | Medicine delivery capsule |
| CN109172937A (en) * | 2018-09-21 | 2019-01-11 | 王筱芳 | A kind of oncology built-in type chemicotherapy pump |
| CN111760177A (en) * | 2020-06-16 | 2020-10-13 | 杭州电子科技大学 | Microcapsule injection type magnetic control robot for targeted drug delivery and control method thereof |
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