CN115089510B - Intelligent temperature-sensitive permanent wave agent capable of reducing thioglycollic acid substances from entering human body and preparation method thereof - Google Patents
Intelligent temperature-sensitive permanent wave agent capable of reducing thioglycollic acid substances from entering human body and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an intelligent temperature-sensitive permanent wave agent capable of reducing thioglycollic acid substances from entering a human body and a preparation method thereof, and belongs to the technical field of cosmetics. The invention uses the chitosan/sodium glycerophosphate hydrogel with temperature-sensitive property to load thioglycollic acid substances, and uses alkyl trimethyl ammonium chloride cationic surfactant to ensure that the chitosan/sodium glycerophosphate forms a gel state and the gelation temperature is adjusted to ensure that the chitosan/sodium glycerophosphate reaches the scalp temperature (32 +/-0.5 ℃). When the permanent waving agent contacts with the scalp, gel can be formed, thereby effectively preventing the mercaptoacetic acid substance from entering the scalp and achieving the effect of slow release; and still has excellent permanent effect because it is still liquid on the hair.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an intelligent temperature-sensitive permanent wave agent capable of reducing thioglycollic acid substances from entering a human body and a preparation method thereof.
Background
At present, factors such as fast pace of life, high pressure, abnormal work and rest and the like cause alopecia and small hair quantity of people. Permanent wave is preferred as a means for increasing the amount of hair in appearance. However, the ammonia water, sulfite and thioglycolic acid substances used for both hot wave and cold wave are toxic substances, and researches prove that the thioglycolic acid has carcinogenic effect and can damage the health of people who love hairdressing and people engaged in hairdressing industry.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: due to the physicochemical properties of thioglycolic acid, after the thioglycolic acid is added into a chitosan/sodium glycerophosphate system, the gel temperature can be greatly increased, and the gel cannot be formed at the scalp temperature (32 +/-0.5 ℃), so that the hair perming agent which has small harm to human bodies and can effectively perm hair is needed.
In order to solve the technical problems, the invention adopts alkyl trimethyl ammonium chloride cationic surfactant to enable chitosan/sodium glycerophosphate to form a gel state and adjust the gelling temperature to enable the chitosan/sodium glycerophosphate to reach the scalp temperature (32 +/-0.5 ℃), and the release of thioglycolic acid is greatly reduced in the gel state.
The technical scheme of the invention is as follows:
the invention provides an intelligent temperature-sensitive permanent wave agent for reducing thioglycollic acid substances from entering a human body, which consists of an agent A and an agent B; wherein, the agent A comprises water, chitosan, sodium glycerophosphate, thioglycollic acid substances, hydrochloric acid, disodium hydrogen phosphate and alkyl trimethyl ammonium chloride; the agent B comprises water, chitosan, sodium glycerophosphate, hydrochloric acid, disodium hydrogen phosphate, hydrogen peroxide, tween 20 or lauramidopropyl betaine.
In one embodiment of the present invention, the agent a comprises the following components by mass: 0.5 to 1 percent of chitosan, 2 to 6 percent of sodium glycerophosphate, 6 to 9 percent of sodium thioglycolate, 0.1 to 0.15 percent of hydrochloric acid, 1.35 to 1.46 percent of alkyl trimethyl ammonium chloride, 1 to 2 percent of disodium hydrogen phosphate and the balance of deionized water.
In one embodiment of the present invention, the agent B comprises the following components by mass: 0.5 to 1.5 percent of chitosan, 3 to 7 percent of sodium glycerophosphate, 0.1 to 0.15 percent of hydrochloric acid, 2 to 6 percent of hydrogen peroxide, 2 to 6 percent of tween or 0.2 to 0.6 percent of lauramidopropyl betaine, 1 to 2 percent of disodium hydrogen phosphate and the balance of deionized water.
In one embodiment of the present invention, the alkyl trimethyl ammonium chloride comprises any one or more of: dodecyl trimethyl ammonium chloride, tetradecyl trimethyl ammonium chloride, and hexadecyl trimethyl ammonium chloride.
In one embodiment of the present invention, the agent a contains 1.42% by mass of alkyl trimethyl ammonium chloride.
The invention also provides a preparation method of the intelligent temperature-sensitive permanent wave agent for reducing the thioglycollic acid substances from entering the human body, which comprises the following steps:
(1) Preparation of an agent A: preparing sodium thioglycolate into a sodium thioglycolate solution with the volume fraction of 10%; dissolving Chitosan (CS) in a hydrochloric acid solution to obtain a clear CS solution; dissolving sodium Glycerophosphate (GP) in deionized water to obtain a clear GP solution; adding the GP solution into the CS solution, adding disodium hydrogen phosphate, and uniformly mixing to obtain a clear CS/GP solution; then adding 10% sodium thioglycollate solution and alkyltrimethylammonium chloride into the CS/GP solution, and uniformly mixing to obtain transparent viscous liquid, namely the agent A;
(2) Preparation of agent B: dissolving Chitosan (CS) in a hydrochloric acid solution to obtain a clear CS solution; dissolving sodium Glycerophosphate (GP) in deionized water to obtain a clear GP solution; adding the GP solution into the CS solution, adding disodium hydrogen phosphate, and uniformly mixing to obtain a clear CS/GP solution; adding Tween 20 or lauramidopropyl betaine and hydrogen peroxide solution into CS/GP solution, mixing well to obtain transparent viscous liquid, and getting agent B.
The invention also provides application of the intelligent temperature-sensitive permanent agent in permanent.
The invention also provides a cold wave method using the intelligent temperature-sensitive permanent wave agent, which comprises the following steps: firstly, using agent A in the intelligent temperature-sensitive permanent wave agent to carry out cold permanent wave, and cleaning after finishing; and then, continuously using the agent B for shaping, cleaning and drying.
In one embodiment of the invention, the agent a is subjected to cold waving for half an hour.
In one embodiment of the invention, the time for setting the agent B is half an hour.
The invention also provides a method for reducing the toxicity of the permanent agent containing the thioglycollic acid substances, wherein chitosan, sodium glycerophosphate and alkyl trimethyl ammonium chloride are simultaneously used in the agent A of the permanent agent, and the specific components comprise water, chitosan, sodium glycerophosphate, the thioglycollic acid substances, hydrochloric acid, disodium hydrogen phosphate and alkyl trimethyl ammonium chloride; the agent B comprises water, chitosan, sodium glycerophosphate, hydrochloric acid, disodium hydrogen phosphate, hydrogen peroxide, tween 20 or lauramidopropyl betaine.
The invention has the beneficial effects that:
the cold perm liquid of the invention forms gel-like solid when contacting scalp at about 32 ℃, and slows down the release speed of thioglycollic acid substances, so that the harm of the thioglycollic acid substances to human bodies can be reduced. Moreover, it can be liquid on the hair below 32 ℃, and has no influence on the perming process.
Thioglycollic acid substances easily enter blood through human scalp and harm body health, and research shows that thioglycollic acid has a carcinogenic effect. The chitosan/sodium glycerophosphate loaded sodium thioglycolate cold perm solution has the gelling temperature of 32 +/-0.5 ℃ and forms gel when contacting scalp, thereby effectively preventing thioglycolic acid substances from entering scalp and achieving the effect of slow release. Compared with common perming products, the invention not only can ensure the health of permitters and working personnel in the hairdressing industry, but also has excellent perming effect.
Detailed Description
Example 1: hydrogel cold wave agent containing cationic surfactant
The agent A comprises the following substances in percentage by mass: 0.7% of chitosan, 4% of sodium glycerophosphate, 7% of sodium thioglycolate, 0.1% of hydrochloric acid, 1.42% of dodecyl trimethyl ammonium chloride, 1.5% of disodium hydrogen phosphate and the balance of deionized water.
The agent B comprises the following substances in parts by mass: 0.7% of chitosan, 4% of sodium glycerophosphate, 0.1% of hydrochloric acid, 3% of hydrogen peroxide, 2% of tween or 0.4% of lauramidopropyl betaine, 1.5% of disodium hydrogen phosphate and the balance of deionized water.
The preparation method comprises the following steps:
the preparation method of the agent A comprises the following steps:
weighing sodium thioglycolate according to the using amount, and preparing the sodium thioglycolate into a solution with the volume fraction of 10%;
weighing hydrochloric acid according to the dosage, diluting with deionized water to prepare a 0.1mol/L solution;
weighing Chitosan (CS) according to the dosage, dissolving in hydrochloric acid solution (0.1 mol/L), and filtering to obtain clear CS solution (0.2 g/L); weighing sodium Glycerophosphate (GP) and dissolving the sodium Glycerophosphate (GP) in deionized water to obtain a clear GP solution (1 g/L); adding the GP solution into the CS solution, continuously stirring, and adjusting the pH to be =7 by using a disodium hydrogen phosphate solution to obtain a clear CS/GP solution;
measuring 10% sodium thioglycolate solution and alkyl trimethyl ammonium chloride, adding into the CS/GP solution, mechanically stirring and mixing uniformly to obtain transparent viscous liquid, namely the agent A.
The preparation method of the agent B comprises the following steps:
weighing Chitosan (CS) according to the dosage, dissolving in hydrochloric acid solution (0.1 mol/L), and filtering to obtain clear CS solution (0.2 g/L); weighing sodium Glycerophosphate (GP) and dissolving the sodium Glycerophosphate (GP) in deionized water to obtain a clear GP solution (1 g/L); adding the GP solution into the CS solution, continuously stirring, and adjusting the pH to be =7 by using a disodium hydrogen phosphate solution to obtain a clear CS/GP solution;
measuring hydrogen peroxide solution (30 mass percent), tween 20 or lauramidopropyl betaine, adding into the CS/GP solution, and mechanically stirring and uniformly mixing to obtain transparent viscous liquid, namely the agent B.
The invention uses cation dodecyl trimethyl ammonium chloride, adjusts the gel temperature (32 +/-0.5 ℃) of the cold perm liquid, and leads the cold perm liquid to be liquid at room temperature and to be in a gel state when contacting with the scalp. Not only ensures the hair-waving effect, but also effectively prevents thioglycollic acid substances from entering the scalp to achieve the effect of slow release.
And (3) testing the perming performance:
preparing 15cm long hair, and perming with the above A and B agents with a curler with diameter of 0.75cm (cold perm is carried out with the A agent, hair is cleaned after half an hour, hair is shaped for half an hour with the B agent, and hair is cleaned and dried). Winding and fixing hair on a hair curler, soaking for 30min with the agent A, soaking for 30min with the agent B after cleaning, and blowing to dry by a blower after cleaning. The hair length after permanent wave is shortened by 7cm, and the curling diameter is 1.3cm.
Transdermal slow release performance test:
two-hour transdermal experiment was performed on the intelligent temperature-sensitive cold wave agent containing cationic (dodecyl trimethyl ammonium chloride) chitosan/sodium glycerophosphate obtained in example 1 and the conventional cold wave agent (mass fraction, 5% thioglycolic acid, 3% anhydrous sodium carbonate, 4.7% urea, 4.7% ammonium bicarbonate, 2% hexamethylenetetramine, 2.7% sodium perborate, 0.67% borax, 3.7% ammonia (mass fraction 25% -28%), and the balance deionized water). Transdermal experiments were performed at the same sodium thioglycolate concentration of 60mg/mL and at 32 deg.C.
Testing procedure of transdermal experiment: franz diffusion cells were used to study drug transdermal behavior in vitro. Treated fresh pig ears were used, cut into circles and placed between the donor and receiver compartments of a diffusion cell, the receiving compartment of which was filled with PBS (pH 7.4) buffer and the temperature was maintained at 32 ± 0.3 ℃. A2 g sample of the hydrogel containing sodium thioglycolate was placed on the pig ear with magnetic stirring at 300 rpm. After 2 hours a 4mL sample was taken and then analyzed by HPLC for sodium thioglycolate content.
The experimental result shows that the maximum transdermal quantity of the traditional cold wave lotion is 2300 mug/cm 2 The transdermal quantity of the intelligent temperature-sensitive cold wave agent is only 920 mu g/cm 2 Even less than half of the traditional cold wave agents. The gel temperature of the intelligent temperature-sensitive cold wave liquid with the formula is about 32 ℃, so that the liquid cold wave liquid is in a liquid state at room temperature and is in a gel state after contacting with scalp for 3 min. The hair perming effect same as that of the traditional hair perming agent is ensured, and thioglycollic acid substances are effectively prevented from entering the scalp, so that the effect of slowly releasing the thioglycollic acid sodium is achieved.
The chitosan/sodium glycerophosphate in the cold wave agent is used as temperature-sensitive hydrogel, is in a liquid state at a lower temperature, and when the temperature rises to a certain value, the electrostatic repulsive force in the polymer is smaller than the attractive force of a hydrogen bond and a hydrophobic bond, and macromolecular chains of the chitosan are aggregated and condensed to form a gel state. By adjusting the dosage of the cationic surfactant, the hydrogel with the gelation temperature about 32 ℃ at the temperature of human scalp is prepared. When the cold perm liquid with the sodium thioglycolate loaded by the chitosan/sodium glycerophosphate contacts the scalp, gel is formed, so that the release speed of thioglycolic acid substances is reduced, and the cold perm liquid is still liquid on the hair due to the fact that the temperature of the hair is lower than 32 ℃, so that the human health is guaranteed, and meanwhile the perm effect can be maintained.
Comparative example 1 hydrogel Cold waving agent without any surfactant
Referring to example 1, only agent a was adjusted:
the agent A comprises: 0.7% of chitosan, 4% of sodium glycerophosphate, 7% of sodium thioglycolate, 0.1% of hydrochloric acid, 1.5% of disodium hydrogen phosphate and the balance of deionized water; the agent B is unchanged.
Permanent waving was carried out using the agents a and B as described above, and as a result, it was found that: the formed cold wave cannot form gel, and the effect of slow release of the cold wave contacting with the scalp cannot be achieved.
Comparative example 2: hydrogel cold wave agent containing anionic surfactant
Referring to example 1, only agent a was adjusted:
the agent A comprises: 0.7% of chitosan, 4% of sodium glycerophosphate, 7% of sodium thioglycolate, 30% of hydrochloric acid, 1% of sodium dodecyl sulfate, 1.5% of disodium hydrogen phosphate and the balance of deionized water; the agent B is unchanged.
The cold permanent wave agent uses anionic sodium dodecyl sulfate surfactant, the cold permanent wave agent forms a gel state at room temperature (20 ℃), the gel-state cold permanent wave liquid on hair wraps sodium thioglycolate molecules, only a small amount of sodium thioglycolate is contacted with hair, and the hair permanent wave effect is almost not achieved.
Comparative example 3: exploring the species of cationic surfactants to compare
Referring to example 1, dodecyl trimethyl ammonium chloride was replaced with octane trimethyl ammonium chloride, tetradecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium chloride, and octadecyl trimethyl ammonium chloride, respectively, and the others were not changed to prepare the corresponding agent a; the same agent B, the perm performance and transdermal slow release performance of the obtained cold wave agent are tested. The results are shown in Table 1.
TABLE 1
Comparative example 4: exploration of the amount of cationic surfactant used for comparison
Referring to example 1, only the amount of dodecyltrimethylammonium chloride was changed (as shown in table 2), and the others were not changed, to obtain the corresponding agent a; the B agents are the same. The agent a was tested for gelling temperature. The results are shown in Table 2.
TABLE 2
| Cationic surfactant concentration/%) | Gel temperature/° C (average) |
| 0.99 | 25.5 |
| 1.18 | 27.5 |
| 1.35 | 30.7 |
| 1.42 | 32.1 |
| 1.46 | 36.6 |
| 1.48 | No coagulation and white solution |
| 1.54 | No coagulation and white solution |
Claims (8)
1. An intelligent temperature-sensitive permanent wave agent for reducing thioglycollic acid substances from entering a human body is characterized by consisting of an agent A and an agent B; wherein, the agent A comprises water, chitosan, sodium glycerophosphate, thioglycollic acid substances, hydrochloric acid, disodium hydrogen phosphate and alkyl trimethyl ammonium chloride; the agent B comprises water, chitosan, sodium glycerophosphate, hydrochloric acid, disodium hydrogen phosphate, hydrogen peroxide, tween-20 or lauramidopropyl betaine;
the agent A comprises the following components in percentage by mass: 0.5 to 1 percent of chitosan, 2 to 6 percent of sodium glycerophosphate, 6 to 9 percent of sodium thioglycolate, 0.1 to 0.15 percent of hydrochloric acid, 1.35 to 1.46 percent of alkyl trimethyl ammonium chloride, 1 to 2 percent of disodium hydrogen phosphate and the balance of deionized water;
the alkyl trimethyl ammonium chloride comprises any one or more of the following components: dodecyl trimethyl ammonium chloride, tetradecyl trimethyl ammonium chloride, and hexadecyl trimethyl ammonium chloride.
2. The intelligent temperature-sensitive permanent waving agent according to claim 1, wherein the agent B comprises the following components in percentage by mass: 0.5 to 1.5 percent of chitosan, 3 to 7 percent of sodium glycerophosphate, 0.1 to 0.15 percent of hydrochloric acid, 2 to 6 percent of hydrogen peroxide, 2 to 6 percent of tween or 0.2 to 0.6 percent of lauramidopropyl betaine, 1 to 2 percent of disodium hydrogen phosphate and the balance of deionized water.
3. The intelligent temperature-sensitive permanent waving agent according to any one of claims 1 to 2, wherein the agent A contains 1.42% of alkyl trimethyl ammonium chloride in percentage by mass.
4. A preparation method of the intelligent temperature-sensitive permanent wave agent for reducing the thioglycolic acid substances entering the human body, which is characterized by comprising the following steps:
(1) Preparation of an agent A: preparing sodium thioglycolate into a 10% sodium thioglycolate solution; dissolving Chitosan (CS) in a hydrochloric acid solution to obtain a clear CS solution; dissolving sodium Glycerophosphate (GP) in deionized water to obtain a clear GP solution; adding the GP solution into the CS solution, adding disodium hydrogen phosphate, and uniformly mixing to obtain a clear CS/GP solution; adding 10% sodium thioglycolate solution and alkyl trimethyl ammonium chloride into the CS/GP solution, and uniformly mixing to obtain transparent viscous liquid, namely the agent A;
(2) Preparation of agent B: dissolving Chitosan (CS) in a hydrochloric acid solution to obtain a clear CS solution; dissolving sodium Glycerophosphate (GP) in deionized water to obtain a clear GP solution; adding the GP solution into the CS solution, adding disodium hydrogen phosphate, and uniformly mixing to obtain a clear CS/GP solution; adding Tween 20 or lauramidopropyl betaine and hydrogen peroxide solution into CS/GP solution, mixing well to obtain transparent viscous liquid, and getting agent B.
5. The use of an intelligent temperature-sensitive permanent wave agent as claimed in any one of claims 1 to 3 in permanent wave.
6. A cold wave method of an intelligent temperature-sensitive type permanent wave agent based on any one of claims 1 to 3, characterized by comprising the following processes: firstly, using agent A in the intelligent temperature-sensitive permanent wave agent to carry out cold permanent wave, and cleaning after finishing; and then, continuously using the agent B for shaping, cleaning and drying.
7. The cold wave method of claim 6, wherein the time for cold wave of the A dose is half an hour and the time for setting of the B dose is half an hour.
8. A method for reducing toxicity of permanent wave agent containing thioglycollic acid substances is characterized in that chitosan, sodium glycerophosphate and alkyl trimethyl ammonium chloride are simultaneously used in the agent A of the permanent wave agent, and the specific components comprise water, chitosan, sodium glycerophosphate, thioglycollic acid substances, hydrochloric acid, disodium hydrogen phosphate and alkyl trimethyl ammonium chloride; the agent B comprises water, chitosan, sodium glycerophosphate, hydrochloric acid, disodium hydrogen phosphate, hydrogen peroxide, tween 20 or lauramidopropyl betaine;
the agent A comprises the following components in percentage by mass: 0.5 to 1 percent of chitosan, 2 to 6 percent of sodium glycerophosphate, 6 to 9 percent of sodium thioglycolate, 0.1 to 0.15 percent of hydrochloric acid, 1.35 to 1.46 percent of alkyl trimethyl ammonium chloride, 1 to 2 percent of disodium hydrogen phosphate and the balance of deionized water;
the alkyl trimethyl ammonium chloride comprises any one or more of the following components: dodecyl trimethyl ammonium chloride, tetradecyl trimethyl ammonium chloride, and hexadecyl trimethyl ammonium chloride.
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| CN113288840A (en) * | 2021-06-25 | 2021-08-24 | 张勇 | Plant extract hair-waving cream and preparation method thereof |
| CN113398010A (en) * | 2021-07-15 | 2021-09-17 | 江南大学 | Intelligent temperature-sensitive hair dye capable of reducing aniline substances from entering human body and preparation method of intelligent temperature-sensitive hair dye |
| CN114479205A (en) * | 2022-02-11 | 2022-05-13 | 台州学院 | Temperature-sensitive hydrogel for treating wounds and preparation method thereof |
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