CN115068368A - Light guide gel and preparation method thereof - Google Patents
Light guide gel and preparation method thereof Download PDFInfo
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- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
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Abstract
The invention discloses a light guide gel which comprises the following substances in parts by weight: 9400.1-10 parts of carbomer, 5-30 parts of glycerol, 0.001-2 parts of sodium ethyl p-hydroxybenzoate, 0.05-15 parts of triethanolamine, 1-95 parts of water for injection, 0.1-3 parts of nano silicon dioxide, 0.05-0.5 part of hexagonal boron nitride and 0.1-0.8 part of amino functionalized hyaluronic acid. The invention also discloses a preparation process of the light guide gel, and a natural swelling method is adopted, so that the molecular structure of the high polymer material is kept from being damaged, and the production efficiency of the product is improved.
Description
Technical Field
The invention relates to the technical field of medical cosmetology, in particular to a light guide gel and a preparation method thereof.
Background
At present, photon cold glue is the main product in the market, mainly is in order to use with the cooperation of photon treatment facility, plays thermal-insulated and leaded light's effect, can prevent skin scald, can also patient's pain. In the plastic and cosmetic scheme, the photon cold gel can be used as a guiding product for protection in an operation, has good light transmittance, strong heat conductivity and no stimulation to skin, so that the protection of a skin barrier system can be ensured, the light guide is uniform, and the stability of the treatment dosage is ensured. In addition, the use of the gel can also protect the probe, thereby protecting expensive instruments and equipment, being convenient to use, free of corrosion, stimulation and pollution, easy to clean, and being used for using the gel in beauty treatment items such as photon, E light skin tendering, depilation, freckle removal, electric wave skin stretching and the like.
However, the photon cold gel on the market at present has the problem of skin allergy after being used.
Disclosure of Invention
The invention aims to provide a light guide gel which has the advantages of safety in use and good protection effect.
The technical purpose of the invention is realized by the following technical scheme:
a light guide gel comprises the following substances in parts by weight:
by adopting the technical scheme, carbomer is used as a main gel component, gel is formed by utilizing the mutual exclusion effect of carboxyl ions, a gel framework is formed, and the carbomer has good biocompatibility and small irritation to skin; the sodium p-hydroxybenzoate is used as a preservative, and the addition amount is small in the pH neutral range of a light guide gel system, the use cost is low, and the safety is high; the carboxyl of triethanolamine and carbomer is neutralized, and the pH is adjusted to form a stable high molecular structure, so that the effects of thickening and moisturizing are achieved.
The gel system of the light guide gel forms non-Newtonian fluid, and the modulus, yield stress and thixotropic property of the linear viscoelastic region of the light guide gel are increased by adding silicon dioxide, so that the fluidity of the light guide gel is promoted, and the light guide gel is conveniently and uniformly coated on the face.
The hexagonal boron nitride has high thermal conductivity, improves the thermal conductivity of the light guide gel, and can quickly transfer local heat through the light guide gel in the photon treatment process, thereby avoiding local burn in the treatment process.
Further setting: the nano silicon dioxide is fumed silica.
By adopting the technical scheme, the fumed silica has better dispersibility in water than the precipitated silica, so that the effect of better controlling the dynamic viscoelasticity of the gel can be achieved under the condition of less addition amount.
Further setting: the amino functionalized hyaluronic acid is a hyaluronic acid-dopamine graft,
the preparation method comprises the following steps: dissolving hyaluronic acid in deionized water, adding catalysts EDC and NHS, fully stirring, adding dopamine hydrochloride, reacting for 18-36h under a vacuum condition, and removing the catalysts and unreacted monomers to obtain the hyaluronic acid-dopamine graft.
By adopting the technical scheme, the dopamine group introduced into the main chain of the hyaluronic acid can change the solution property of the pure HA, particularly change the intramolecular and intermolecular interaction between hyaluronic acid chain segments, and the hydrophobic benzene ring element on the dopamine endows the hyaluronic acid with certain amphipathy, so that the hyaluronic acid-dopamine graft is respectively contacted with a water phase and an oil phase in the light guide gel and distributed on the surface of the light guide gel, thereby being contacted with the skin and permeating into the surface layer of the skin, being beneficial to the supply of nutrient substances and the discharge of metabolites, preventing the skin from aging and playing a role in nourishing the skin.
Further setting: the hexagonal boron nitride is alanine modified hexagonal boron nitride, and the preparation method comprises the following steps:
adding hexagonal boron nitride, alanine and alkaline solution into a ball mill, screening out ball milling beads after ball milling, neutralizing to be neutral through hydrochloric acid, filtering, washing, and drying in vacuum to obtain alanine modified hexagonal boron nitride.
By adopting the technical scheme, the interaction between the amino group of the alanine and the boron atom of the hexagonal boron nitride is promoted by utilizing a ball milling mode, the hexagonal boron nitride lamella is thinned, and a layer of carboxyl-containing organic compound is covered on the surface of the hexagonal boron nitride, so that the compatibility of the modified hexagonal boron nitride and a high polymer material is greatly improved, and the modified hexagonal boron nitride can be better combined with a gel system.
Further setting: the light guide gel comprises the following substances in parts by weight:
the invention also aims to provide a preparation method of the light guide gel, which has the advantages of high product quality and high production efficiency.
The technical purpose of the invention is realized by the following technical scheme:
the preparation method of the light guide gel comprises the following steps:
sp1, adding carbomer 940 into glycerol, and stirring to obtain carbomer solution;
sp2, adding water into carbomer solution, stirring uniformly, soaking for 6-10h, and swelling sufficiently to obtain pre-gel;
sp3, sequentially dissolving ethyl p-hydroxybenzoate, nano silicon dioxide and amino functionalized hyaluronic acid in a proper amount of water, and slowly adding the solution into the pre-gel under the stirring condition to obtain pre-mixed gel;
sp4, adding triethanolamine and hexagonal boron nitride into the premixed gel, and slowly stirring uniformly in vacuum.
By adopting the technical scheme, white precipitate is easy to separate out when the sodium p-hydroxybenzoate is used, namely, the p-hydroxybenzoate root ions capture hydrogen ions in the solution in acidity or weak acidity and are recovered to be p-hydroxybenzoate again, and the p-hydroxybenzoate precipitate is separated out under the condition of local over-concentration, so that the sodium p-hydroxybenzoate is firstly prepared into the solution before adding, and is slowly added under stirring to prevent the p-hydroxybenzoate precipitate from separating out due to local over-concentration.
In conclusion, the invention has the following beneficial effects: the invention adopts the food preservative of the sodium ethyl p-hydroxybenzoate, increases the safety of the product and solves the defects of the existing product. The production process is innovative, and the common production process is stirring and shearing by a homogenizer, so that the molecular structure of the high polymer material is broken under the high-speed shearing of the homogenizer, and the viscosity is reduced. The natural swelling method is adopted, so that the molecular structure of the high polymer material is kept from being damaged, and the production efficiency of the product is improved.
Detailed Description
Example 1:
a light directing gel comprising the following by weight: (unit: g)
Wherein the nano silicon dioxide is gas phase silicon dioxide, the amino functionalized hyaluronic acid is hyaluronic acid-dopamine graft, and the hexagonal boron nitride is alanine modified hexagonal boron nitride.
The preparation method comprises the following steps:
sp1, adding carbomer 940 into glycerol, and stirring to obtain carbomer solution;
sp2, adding water into carbomer solution, stirring uniformly, soaking for 6-10h, and swelling sufficiently to obtain pre-gel;
sp3, dissolving ethyl p-hydroxybenzoate sodium, nano silicon dioxide and amino functionalized hyaluronic acid in a proper amount of water in sequence, and slowly adding the solution into the pre-gel under the stirring condition to obtain pre-mixed gel;
sp4, adding triethanolamine and hexagonal boron nitride into the premixed gel, and slowly stirring uniformly in vacuum.
Example 2:
a light directing gel comprising the following by weight: (unit: g)
Wherein the nano silicon dioxide is gas phase silicon dioxide, the amino functionalized hyaluronic acid is hyaluronic acid-dopamine graft, and the hexagonal boron nitride is alanine modified hexagonal boron nitride.
The preparation method comprises the following steps:
sp1, adding carbomer 940 into glycerol, and stirring to obtain carbomer solution;
sp2, adding water into carbomer solution, stirring uniformly, soaking for 6-10h, and swelling sufficiently to obtain pre-gel;
sp3, dissolving ethyl p-hydroxybenzoate sodium, nano silicon dioxide and amino functionalized hyaluronic acid in a proper amount of water in sequence, and slowly adding the solution into the pre-gel under the stirring condition to obtain pre-mixed gel;
sp4, adding triethanolamine and hexagonal boron nitride into the premixed gel, and slowly stirring uniformly in vacuum.
Example 3:
a light directing gel comprising the following by weight: (unit: g)
Wherein the nano silicon dioxide is gas phase silicon dioxide, the amino functionalized hyaluronic acid is hyaluronic acid-dopamine graft, and the hexagonal boron nitride is alanine modified hexagonal boron nitride.
The preparation method comprises the following steps:
sp1, adding carbomer 940 into glycerol, and stirring to obtain carbomer solution;
sp2, adding water into carbomer solution, stirring, soaking for 6-10h, and swelling to obtain pre-gel;
sp3, dissolving ethyl p-hydroxybenzoate sodium, nano silicon dioxide and amino functionalized hyaluronic acid in a proper amount of water in sequence, and slowly adding the solution into the pre-gel under the stirring condition to obtain pre-mixed gel;
sp4, adding triethanolamine and hexagonal boron nitride into the premixed gel, and slowly stirring uniformly in vacuum.
Example 4:
a light directing gel comprising the following by weight: (unit: g)
Wherein the nano silicon dioxide is gas phase silicon dioxide, the amino functionalized hyaluronic acid is hyaluronic acid-dopamine graft, and the hexagonal boron nitride is alanine modified hexagonal boron nitride.
The preparation method comprises the following steps:
sp1, adding carbomer 940 into glycerol, and stirring to obtain carbomer solution;
sp2, adding water into carbomer solution, stirring uniformly, soaking for 6-10h, and swelling sufficiently to obtain pre-gel;
sp3, sequentially dissolving ethyl p-hydroxybenzoate, nano silicon dioxide and amino functionalized hyaluronic acid in a proper amount of water, and slowly adding the solution into the pre-gel under the stirring condition to obtain pre-mixed gel;
sp4, adding triethanolamine and hexagonal boron nitride into the premixed gel, and slowly stirring uniformly in vacuum.
Example 5:
a light directing gel comprising the following by weight: (unit: g)
Wherein the nano silicon dioxide is gas phase silicon dioxide, the amino functionalized hyaluronic acid is hyaluronic acid-dopamine graft, and the hexagonal boron nitride is alanine modified hexagonal boron nitride.
The preparation method comprises the following steps:
sp1, adding carbomer 940 into glycerol, and stirring to obtain carbomer solution;
sp2, adding water into carbomer solution, stirring uniformly, soaking for 6-10h, and swelling sufficiently to obtain pre-gel;
sp3, dissolving ethyl p-hydroxybenzoate sodium, nano silicon dioxide and amino functionalized hyaluronic acid in a proper amount of water in sequence, and slowly adding the solution into the pre-gel under the stirring condition to obtain pre-mixed gel;
sp4, adding triethanolamine and hexagonal boron nitride into the premixed gel, and slowly stirring uniformly in vacuum.
Comparative example 1:
a light directing gel comprising the following by weight: (unit: g)
Wherein the nano silicon dioxide is precipitated silicon dioxide, the amino functionalized hyaluronic acid is a hyaluronic acid-dopamine graft, and the hexagonal boron nitride is alanine modified hexagonal boron nitride.
The preparation method comprises the following steps:
sp1, adding carbomer 940 into glycerol, and stirring to obtain carbomer solution;
sp2, adding water into carbomer solution, stirring uniformly, soaking for 6-10h, and swelling sufficiently to obtain pre-gel;
sp3, dissolving ethyl p-hydroxybenzoate sodium, nano silicon dioxide and amino functionalized hyaluronic acid in a proper amount of water in sequence, and slowly adding the solution into the pre-gel under the stirring condition to obtain pre-mixed gel;
sp4, adding triethanolamine and hexagonal boron nitride into the premixed gel, and slowly and uniformly stirring in vacuum.
Comparative example 2:
a light directing gel comprising the following by weight: (unit: g)
Wherein the nano silicon dioxide is gas phase silicon dioxide, the amino functionalized hyaluronic acid is hyaluronic acid-dopamine graft, and the hexagonal boron nitride is unmodified hexagonal boron nitride.
The preparation method comprises the following steps:
sp1, adding carbomer 940 into glycerol, and stirring to obtain carbomer solution;
sp2, adding water into carbomer solution, stirring uniformly, soaking for 6-10h, and swelling sufficiently to obtain pre-gel;
sp3, dissolving ethyl p-hydroxybenzoate sodium, nano silicon dioxide and amino functionalized hyaluronic acid in a proper amount of water in sequence, and slowly adding the solution into the pre-gel under the stirring condition to obtain pre-mixed gel;
sp4, adding triethanolamine and hexagonal boron nitride into the premixed gel, and slowly stirring uniformly in vacuum.
Comparative example 3:
a light directing gel comprising the following by weight: (unit: g)
Wherein the nano silicon dioxide is gas phase silicon dioxide, the amino functionalized hyaluronic acid is hyaluronic acid-dopamine graft, and the hexagonal boron nitride is alanine modified hexagonal boron nitride.
The preparation method comprises the following steps:
sp1, adding carbomer 940 into glycerol, and stirring to obtain carbomer solution;
sp2, sequentially dissolving ethyl p-hydroxybenzoate sodium, nano silicon dioxide and amino functionalized hyaluronic acid in a proper amount of water, mixing with carbomer solution, stirring in a high-speed homogenizer, and swelling to obtain premixed gel;
sp4, adding triethanolamine and hexagonal boron nitride into the premixed gel, and slowly stirring uniformly in vacuum.
And (3) performance detection:
the following tests were carried out on the hydrogels selected in the examples and comparative examples, respectively:
and (3) detecting the rotational viscosity: measured by rotational viscometer according to the third method of viscometry of the fourth 0633 part of pharmacopoeia of the people's republic of China (2015 edition).
Skin sensitization test: the test solution is taken to carry out a skin sensitization test according to the method specified in GB/T16886.10-2017.
And (3) detecting the light transmittance: the hydrogel was cut into pieces of 20mm × 10mm × 5mm, placed in a cuvette of 40mm × 10mm × 5mm, and distilled water was injected into the cuvette. The transmittance of the gel was measured at 500nm using a visible spectrophotometer model 721B.
And (3) detecting the heat conductivity coefficient: the thermal conductivity was measured using a TC3000 thermal conductivity measuring instrument. The results of the above tests are reported in table 1 below.
TABLE 1 recording table of light-conducting gel test results
| Rotational viscosity (cp) | Skin sensitization test | Light transmittance | Thermal conductivity (W/(m.K)) | |
| Example 1 | 10000-15000 | Grade no more than 1 | 88％ | 0.675 |
| Example 2 | 10000-15000 | Grade no more than 1 | 89％ | 0.684 |
| Example 3 | 10000-15000 | Grade no more than 1 | 91％ | 0.701 |
| Example 4 | 10000-15000 | Grade no more than 1 | 87％ | 0.694 |
| Example 5 | 10000-15000 | Grade no more than 1 | 86％ | 0.669 |
| Comparative example 1 | 15000-20000 | Grade no more than 1 | 88％ | 0.596 |
| Comparative example 2 | 10000-15000 | Grade less than or equal to 1 | 89％ | 0.537 |
| Comparative example 3 | ＜10000 | Stage 2 | 82％ | 0.567 |
As can be seen from Table 1, the light guide gel provided by the embodiment of the invention has the advantages of good light transmission, low skin irritation, high heat conductivity, safety in use, and good light guide and heat dissipation effects; compared with the embodiment, the viscosity of the comparative example 1 is obviously increased, so that the fumed silica has a better dispersion lubrication effect compared with the precipitated silica, and the heat conductivity coefficient is reduced, mainly because the hexagonal boron nitride is not sufficiently dispersed in the light guide gel, the heat conductivity of the hexagonal boron nitride is not fully exerted; in the comparative example 2, the hexagonal boron nitride has poor binding capacity with the gel and poor heat conductivity of the light guide gel due to no modification; comparative example 3 since the conventional high-speed homogenizer was used for stirring, the molecules in the gel material were destroyed and the performance was significantly reduced.
The above-described embodiments do not limit the scope of the present invention. Any modification, equivalent replacement, and improvement made within the spirit and principle of the above-mentioned embodiments should be included in the protection scope of the technical solution.
Claims (6)
1. The light guide gel is characterized by comprising the following substances in parts by weight:
2. the ABC of claim 1, wherein the nano silica is fumed silica.
3. The ABC of claim 1, wherein the amino functionalized hyaluronic acid is a hyaluronic acid-dopamine graft,
the preparation method comprises the following steps: dissolving hyaluronic acid in deionized water, adding catalysts EDC and NHS, stirring thoroughly, adding dopamine hydrochloride, reacting for 18-36h under vacuum condition, and removing catalyst and unreacted monomer to obtain hyaluronic acid-dopamine graft.
4. The ABC of claim 1, wherein the hexagonal boron nitride is alanine modified hexagonal boron nitride and is prepared by the following steps:
adding hexagonal boron nitride, alanine and alkaline solution into a ball mill, screening out ball milling beads after ball milling, neutralizing to be neutral through hydrochloric acid, filtering, washing, and drying in vacuum to obtain alanine modified hexagonal boron nitride.
5. The ABC of claim 1, wherein the light directing gel comprises the following parts by weight of materials:
6. a method of making a light directing gel according to any of claims 1-5, comprising the steps of:
sp1, adding carbomer 940 into glycerol, and stirring to obtain carbomer solution;
sp2, adding water into carbomer solution, stirring uniformly, soaking for 6-10h, and swelling sufficiently to obtain pre-gel;
sp3, dissolving ethyl p-hydroxybenzoate sodium, nano silicon dioxide and amino functionalized hyaluronic acid in a proper amount of water in sequence, and slowly adding the solution into the pre-gel under the stirring condition to obtain pre-mixed gel;
sp4, adding triethanolamine and hexagonal boron nitride into the premixed gel, and slowly stirring uniformly in vacuum.
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Citations (5)
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| CN102702539A (en) * | 2012-06-29 | 2012-10-03 | 江南大学 | Method for preparing dopamine-modified hyaluronic acid micelle |
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| CN102702539A (en) * | 2012-06-29 | 2012-10-03 | 江南大学 | Method for preparing dopamine-modified hyaluronic acid micelle |
| CN105044359A (en) * | 2015-07-14 | 2015-11-11 | 天津大学 | Surface plasma resonator chip based on modification of hyaluronic acid assisted by dopamine and preparation method of chip |
| JPWO2017126143A1 (en) * | 2016-01-21 | 2018-06-28 | 株式会社リタファーマ | Water-soluble hyaluronic acid gel and method for producing the same |
| JP2019536850A (en) * | 2016-11-18 | 2019-12-19 | フィディア ファルマチェウティチ エス．ピー．エー． | Sulfated hyaluronic acid functionalized with dopamine |
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| 陈莹等: "丙氨酸改性氮化硼在PVA导热水凝胶中的应用", 《当代化工研究》 * |
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