CN115067940A - Blood sampling and detecting device - Google Patents

Abstract

A blood sampling and detecting device is suitable for carrying out swabbing sampling and detecting on blood of a human body, and comprises: at least one micro needle for inserting into a blood vessel of a human body to perform blood collection and examination; a reservoir, which is communicated with the micro needle head and is used for collecting blood, and comprises a suction pipe which is communicated with the inner space of the reservoir; a fluid transmission control system comprises a fluid transmission device, a driving controller and a power supply, wherein the fluid transmission device is arranged and communicated with one end of a suction pipe and can operate the internal space of a pumping storage, the power supply provides a power supply for the driving controller to start the fluid transmission device, and the fluid transmission device is actuated to control the internal space of the storage to form a pressure difference so that blood of a micro needle inserted into a blood vessel is pumped and stored in the storage.

Description

Blood sampling and detecting device

[ technical field ] A method for producing a semiconductor device

The invention relates to a blood sampling and detecting device which is suitable for performing swabbing sampling and detecting on blood of a human body.

[ background of the invention ]

Due to the evolution of medical technology, hospitals have more and more information found in the blood of patients, doctors can clearly know the disease or germ infected by the patients to judge whether the physiological functions and functions of the patients are normal, and the reference of the causes and medical treatment modes of the doctors is provided, so that the number of patients who go to the hospitals or health centers for blood drawing tests is more and more nowadays.

At present, a medical hemospast mainly comprises a needle cylinder, a needle head and a piston rod, when a hemospast is used for blood test, medical staff insert the needle head into a hemospast part of a patient, pull the piston rod by hands to form a negative pressure environment in an inner space of the needle cylinder, so as to provide negative pressure suction force to enable the needle head to complete blood hemospast. However, in such medical practice, the medical staff manually draws blood, and the dosage and speed of blood drawing are not quantitative and constant, and the patient feels uncomfortable when drawing blood. In other words, the blood drawing method relying on manual blood drawing cannot accurately control the blood drawing amount and the blood drawing speed, and the patient feels uncomfortable during the blood drawing process.

Therefore, how to design a device for performing blood drawing test by means of mechanism instead of manual work to reduce the discomfort of the patient is the main subject of the present invention.

[ summary of the invention ]

The invention relates to a blood sampling and detecting device, which mainly aims to provide a fluid transmission control system for controlling the internal space of a storage to form pressure difference so that a micro needle can be inserted into a blood vessel to pump blood and then is stored in the storage.

To achieve the above object, the blood sampling and testing device of the present invention is adapted to perform a swabbing sampling and testing on blood of a human body, and includes: at least one micro needle for inserting into a blood vessel of a human body to perform blood collection and examination; a reservoir, which is communicated with the micro needle and is used for collecting blood, and comprises a suction tube which is communicated with the inner space of the reservoir; a fluid transmission control system comprises a fluid transmission device, a driving controller and a power supply, wherein the fluid transmission device is arranged and communicated with one end of a suction pipe and can operate and draw the inner space of a storage device, the power supply provides a power supply for the driving controller to start the fluid transmission device, the fluid transmission device is actuated to control the inner space of the storage device to form a pressure difference, and blood inserted into a blood vessel by a micro needle head is drawn and stored in the storage device.

[ description of the drawings ]

FIG. 1A is a schematic view of the present invention showing a hollow soft needle with a solid thin needle exposed by pushing a piston rod.

FIG. 1B is a schematic view of the present invention drawing back the plunger rod to retract the solid fine needle into the hollow soft needle.

FIG. 1C is a schematic view of the micro-needle of the present invention separated from the reservoir.

FIG. 1D is a schematic view of the combination of the microneedle, reservoir and fluid delivery control system of the present invention, and drawing blood.

FIG. 1E is a schematic view of another embodiment of the present invention showing the micro-needle, reservoir and fluid transfer control system in combination for drawing blood.

FIG. 2A is an exploded view of the gas pump of the present invention.

FIG. 2B is a schematic view of the gas pump of the present invention from another perspective, with parts broken away.

FIG. 3A is a schematic sectional view of the gas pump assembly of the present invention.

FIG. 3B is a schematic sectional view of the gas pump assembly according to the present invention.

FIG. 3C is a schematic sectional view of the gas pump assembly according to the present invention.

FIG. 3D is a schematic sectional view of the gas pump assembly of the present invention.

FIG. 4A is a perspective view of the box-type gas pump according to the present invention.

FIG. 4B is a schematic exploded perspective view of the box-type gas pump of the present invention.

FIG. 4C is a schematic view of the box-type gas pump of the present invention shown in a three-dimensional exploded view from another perspective.

FIG. 5A is a schematic sectional view of the box-type gas pump assembly of the present invention.

FIG. 5B is a schematic sectional view of the box-type gas pump assembly according to the present invention.

FIG. 5C is a schematic sectional view of the box-type gas pump assembly according to the present invention.

Fig. 6 is a schematic cross-sectional view of the mems pump assembly of the present invention.

Fig. 7A is a schematic sectional view of the mems pump assembly according to the present invention. Fig. 7B is a schematic sectional view of the mems pump assembly according to the present invention. Fig. 7C is a schematic sectional view of the mems pump assembly according to the third embodiment of the present invention.

[ notation ] to show

1: micro needle

1 a: hollow soft needle

1 b: solid fine needle

1 c: piston rod

2: storage device

20: blood sensor

21: pumping pipe

22: connector with a locking member

3: fluid transfer control system

31: fluid transfer device

32: drive controller

33: power supply

4: gas pump

41: intake plate

41 a: inlet orifice

41 b: bus bar groove

41 c: confluence chamber

42: resonance sheet

42 a: hollow hole

42 b: movable part

42 c: fixing part

43: piezoelectric actuator

43 a: suspension plate

43 b: outer frame

43 c: support frame

43 d: piezoelectric element

43 e: gap

43 f: convex part

44: first insulating sheet

45: conductive sheet

46: second insulating sheet

47: chamber space

5: box type gas pump

51: air injection hole sheet

511: suspension plate

512: center hole

52: cavity frame

53: actuating body

531: piezoelectric support plate

532: tuning the resonator plate

533: piezoelectric plate

54: insulating frame

55: conductive frame

56: resonance chamber

57: airflow chamber

58: gap

6: MEMS pump

60: spacer layer

61: base material

62: the first chamber

63: resonance board

63 a: hollow hole

63 b: movable part

64: actuating plate

64 a: suspension part

64 b: outer frame part

64 c: through hole

65: piezoelectric element

66: outlet plate

66 a: an outlet orifice

67: entrance plate

67 a: inlet aperture

68: second chamber

69: third chamber

A: blood vessel

[ detailed description ] embodiments

Embodiments that embody the features and advantages of this disclosure will be described in detail in the description that follows. It is to be understood that the invention is capable of modification in various respects, all without departing from the scope of the invention, and that the description and drawings are to be regarded as illustrative in nature, and not as restrictive.

Referring to fig. 1A to 1D, a blood sampling and testing device according to a first preferred embodiment of the present invention is adapted to perform a swabbing sampling and testing on blood of a human body, and includes: at least one micro-needle 1, a reservoir 2 and a fluid transfer control system 3.

The micro needle head 1 is used for inserting into a blood vessel A of a human body to carry out blood sampling, the micro needle head 1 comprises a hollow soft needle 1a which is coated with a solid thin needle 1b and a piston rod 1c, the solid thin needle 1b is sleeved in the hollow soft needle 1a and slightly exposed, and the piston rod 1c is connected with the solid thin needle 1 b. When blood is drawn, the piston rod 1c is pushed to make the solid thin needle 1b puncture the blood vessel A of the human body and drive the hollow soft needle 1a to be smoothly inserted into the blood vessel A, and then the piston rod 1c is drawn back to drive the solid thin needle 1b to draw out the blood vessel A and leave the hollow soft needle 1a in the blood vessel A of the human body. Wherein, the length of the hollow soft needle 1a is 1000-2000 microns (mum), and the hollow aperture is 10-1000 microns (mum).

The storage 2 is connected to the micro needle 1 for storing blood, the storage 2 is provided with a blood sensor 20, a suction tube 21 and a connector 22, and the connector 22 is connected between the storage 2 and the suction tube 21, so that the storage 2 and the suction tube 21 can be detached or combined. The blood sensor 20 detects the presence of blood in the reservoir 2 to determine whether the microneedle 1 is properly inserted into the blood vessel a, and the suction tube 21 communicates with the inner space of the reservoir 2.

The fluid transfer control system 3 comprises a fluid transfer device 31, a driving controller 32 and a power supply 33, wherein the fluid transfer device 31 is connected to one end of the suction tube 21 and is capable of pumping the internal space of the reservoir 2, the power supply 33 provides a power to the driving controller 32 for activating the fluid transfer device 31, so that the fluid transfer device 31 is activated to control the internal space of the reservoir 2 to form a pressure difference, and the micro-needle 1 is inserted into the blood vessel a to pump blood and is stored in the reservoir 2.

In this embodiment, the micro needle 1, the reservoir 2 and the suction tube 21 can be disposable, and a check valve (not shown) is disposed at a position where the fluid transmission control system 3 communicates with the suction tube 21, so as to prevent blood from flowing back to the fluid transmission control system 3, thereby making the fluid transmission control system 3 reusable.

Referring to fig. 1E, a second preferred embodiment of the present invention is a blood sampling and testing device, which is suitable for performing swabbing and sampling test on blood of a human body, and comprises: a plurality of micro-needles 1, a reservoir 2 and a fluid transmission control system 3.

The micro needles 1 are provided for inserting into a blood vessel A of a human body to perform a blood collection. Wherein, the length of the hollow soft needle 1a is 1000-2000 microns (mum), and the hollow aperture is 10-1000 microns (mum).

The storage 2 is connected to the plurality of micro needles 1 for storing blood, the storage 2 is provided with a blood sensor 20, a pumping tube 21 and a connector 22, and the connector 22 is connected between the storage 2 and the pumping tube 21, so that the storage 2 and the pumping tube 21 can be detached or connected and combined. The blood sensor 20 detects the presence of blood in the reservoir 2 to determine whether the microneedle 1 is properly inserted into the blood vessel a, and the suction tube 21 communicates with the inner space of the reservoir 2.

The fluid transfer control system 3 comprises a fluid transfer device 31, a driving controller 32 and a power supply 33, wherein the fluid transfer device 31 is connected to one end of the suction tube 21 and is capable of pumping the internal space of the reservoir 2, the power supply 33 provides a power to the driving controller 32 for activating the fluid transfer device 31, so that the fluid transfer device 21 is activated to control the internal space of the reservoir 2 to form a pressure difference, and a plurality of micro-needles 1 are inserted into the blood vessel a to pump blood and are stored in the reservoir 2.

In this embodiment, the plurality of microneedles 1, the reservoir 2 and the suction tube 21 can be disposable, and a check valve (not shown) is disposed at a position where the fluid transmission control system 3 communicates with the suction tube 21, so that blood can be prevented from flowing back to the fluid transmission control system 3 through the check valve, thereby allowing the fluid transmission control system 3 to be reusable.

Referring to fig. 2A to 3D, the fluid transfer device 31 is a gas pump 4, and the gas pump 4 includes a flow inlet plate 41, a resonant plate 42, a piezoelectric actuator 43, a first insulating plate 44, a conductive plate 45 and a second insulating plate 46 sequentially stacked and assembled. The flow inlet plate 41 has at least one flow inlet hole 41a, at least one bus groove 41b and a flow converging chamber 41c, the flow inlet hole 41a is used for introducing gas, the flow inlet hole 41a correspondingly penetrates through the flow converging chamber 41b, and the flow converging chamber 41c is converged by the flow converging groove 41b, so that the gas introduced by the flow inlet hole 41a can be converged into the flow converging chamber 41 c. In the present embodiment, the number of the inflow holes 41a and the number of the bus grooves 41b are the same, the number of the inflow holes 41a and the number of the bus grooves 41b are 4 respectively, and not limited thereto, the 4 inflow holes 41a are respectively communicated to the 4 bus grooves 41b, and the 4 bus grooves 41b are merged to the bus chamber 41 c.

The above-mentioned resonator plate 42 is assembled on the flow inlet plate 41 by means of adhesion, and the resonator plate 42 has a hollow hole 42a, a movable portion 42b and a fixed portion 42c, the hollow hole 42a is located at the center of the resonator plate 42 and corresponds to the confluence chamber 41c of the flow inlet plate 41, the movable portion 42b is disposed at the area around the hollow hole 42a and opposite to the confluence chamber 41c, and the fixed portion 42c is disposed at the outer peripheral edge portion of the resonator plate 42 and is adhered and fixed on the flow inlet plate 41.

The piezoelectric actuator 43 is bonded to the resonator plate 42 and includes a suspension plate 43a, an outer frame 43b, at least one support 43c, a piezoelectric element 43d, at least one gap 43e and a protrusion 43 f. The suspension plate 43a is in a square shape, the suspension plate 43a is square, compared with the design of a circular suspension plate, the structure of the square suspension plate 43a obviously has the advantage of power saving, the consumed power of the square suspension plate 43a is increased along with the increase of the frequency due to the capacitive load operated under the resonant frequency, and the relative consumed power of the square suspension plate 43a is also obviously lower due to the fact that the resonant frequency of the square suspension plate 43a is obviously lower than that of the circular suspension plate, namely, the square suspension plate 43a adopted by the scheme has the benefit of power saving; the outer frame 43b is arranged around the outer side of the suspension plate 43 a; at least one bracket 43c connected between the suspension plate 43a and the outer frame 43b to provide a supporting force for elastically supporting the suspension plate 43 a; and a piezoelectric element 43d having a side length less than or equal to a side length of a suspension plate 43a of the suspension plate 43a, and the piezoelectric element 43d is attached to a surface of the suspension plate 43a for applying a voltage to drive the suspension plate 43a to vibrate in a bending manner; at least one gap 43e is formed among the suspension plate 43a, the outer frame 43b and the bracket 43c for air to pass through; the convex portion 43f is disposed on the opposite surface of the suspension plate 43a to which the piezoelectric element 43d is attached, and in the present embodiment, the convex portion 43f is formed by integrally forming the suspension plate 43a by an etching process so as to protrude from the opposite surface of the surface to which the piezoelectric element 43d is attached.

The flow inlet plate 41, the resonator plate 42, the piezoelectric actuator 43, the first insulating plate 44, the conductive plate 45 and the second insulating plate 46 are sequentially stacked and combined, wherein a cavity space 47 needs to be formed between the suspension plate 43a of the piezoelectric actuator 43 and the resonator plate 42, and the cavity space 47 can be formed by filling a material in a gap between the resonator plate 42 and the outer frame 43b of the piezoelectric actuator 43, for example: the conductive adhesive, but not limited thereto, maintains a certain depth between the resonator plate 42 and a surface of the suspension plate 43a to form the cavity space 47, so as to guide the gas to flow more rapidly, and since the suspension plate 43a and the resonator plate 42 maintain a proper distance to reduce the mutual contact interference, the noise generation can be reduced, in another embodiment, the height of the outer frame 43b of the piezoelectric actuator 43 can be increased to reduce the thickness of the conductive adhesive filled in the gap between the resonator plate 42 and the outer frame 43b of the piezoelectric actuator 43, so that the overall structural assembly of the gas pump 4 is not affected by the thermal compression temperature and the cooling temperature indirectly, and the filling material of the conductive adhesive is prevented from affecting the actual distance of the cavity space 47 after molding due to thermal contraction, but not limited thereto. In addition, the chamber space 47 will affect the transmission efficiency of the gas pump 4, so it is important to maintain a fixed chamber space 47 for providing stable transmission efficiency of the gas pump 4.

In order to understand the output actuation manner of the gas pump 4 for providing gas transmission, please continue to refer to fig. 3B to 3D, the piezoelectric element 43D of the piezoelectric actuator 43 is deformed to drive the suspension plate 43a to move downward after being applied with the driving voltage, at this time, the volume of the chamber space 47 is increased, a negative pressure is formed in the chamber space 47, so as to draw the gas in the confluence chamber 41c into the chamber space 47, and the resonance plate 42 is synchronously moved downward under the influence of the resonance principle, thereby increasing the volume of the confluence chamber 41c, and the gas in the confluence chamber 41c is also in a negative pressure state due to the relationship that the gas in the confluence chamber 41c enters the chamber space 47, and further, the gas is drawn into the confluence chamber 41c through the inflow hole 41a and the confluence groove 41B; the piezoelectric element 43d drives the suspension plate 43a to move upwards to compress the chamber space 47, and similarly, the resonance sheet 42 is moved upwards by the suspension plate 43a due to resonance, so that the gas in the chamber space 47 is pushed synchronously downwards and is transmitted downwards through the gap 43e, and the effect of transmitting the gas is achieved; when the floating plate 43a returns to the original position, the resonator 42 still moves downward due to inertia, and at this time, the resonator 42 moves the gas in the compression chamber space 47 to the gap 43e, and increases the volume in the confluence chamber 41c, so that the gas can continuously pass through the inflow hole 41a and the bus groove 41b to be converged in the confluence chamber 41c, and by continuously repeating the gas transmission actuation step provided by the gas pump 4, the gas pump 4 can continuously enter the flow channel formed by the inflow plate 41a and the resonator 42 to generate a pressure gradient, and then is transmitted downward through the gap 43e, so that the gas flows at a high speed, and the actuation operation of the gas output transmitted by the gas pump 4 is achieved.

Referring to fig. 4A to 5C, the fluid transfer device 31 is a box-type gas pump 5, and the box-type gas pump 5 includes a gas injection hole 51, a cavity frame 52, an actuator 53, an insulating frame 54 and a conductive frame 55. Wherein the air-jet hole piece 51 comprises a suspension piece 511 and a central hole 512, the suspension piece 511 can be bent and vibrated, and the central hole 512 is formed at the central position of the suspension piece 511; the cavity frame 52 is carried and superposed on the suspension plate 511; the actuating body 53 is formed by sequentially stacking a piezoelectric carrier plate 531, an adjusting resonator plate 532 and a piezoelectric plate 533, and the piezoelectric carrier plate 531 is stacked on the cavity frame 52 and stacked on the cavity frame 52 to receive a voltage to generate a reciprocating bending vibration; the insulating frame 54 carries a piezoelectric carrier plate 531 superimposed on the actuating body 53; and the conductive frame 55 is stacked on the insulating frame 54; therefore, the air injection hole sheet 51 is fixedly positioned, a gap 58 is defined on the side edge of the air injection hole sheet 51 to surround the air injection hole sheet for the circulation of fluid, an air flow chamber 57 is formed between the bottom of the air injection hole sheet 51, a resonance chamber 56 is formed among the actuating body 53, the cavity frame 52 and the suspension sheet 511, the actuating body 53 is driven to drive the air injection hole sheet 51 to resonate, the suspension sheet 511 of the air injection hole sheet 51 generates reciprocating vibration displacement, the suction fluid enters the air flow chamber 57 through the gap 58 and is discharged, and the transmission flow of the fluid is realized.

When the piezoelectric plate 533 drives the floating piece 511 of the jet hole piece 51 to move towards the direction far away from the bottom surface, the floating piece 511 of the jet hole piece 51 is driven to move towards the direction far away from the bottom surface of the positioning containing seat, so that the volume of the air flow chamber 57 is expanded sharply, the internal pressure thereof is reduced to form negative pressure, the air outside the drawing box-type air pump 5 flows in from the plurality of gaps 58 and enters the resonance chamber 56 through the central hole 512, and the air pressure in the resonance chamber 56 is increased to generate a pressure gradient; as shown in fig. 5C, when the piezoelectric plate 533 drives the floating plate 511 of the air injection hole plate 51 to move toward the bottom surface, the gas in the resonant chamber 56 flows out rapidly through the central hole 512, and presses the fluid in the air flow chamber 57, so that the collected fluid is injected rapidly and in large quantities in an ideal fluid state close to the bernoulli's law. The pressure inside the resonance chamber 56 after the fluid is discharged is lower than the equilibrium pressure, which leads the fluid to re-enter the resonance chamber 56, according to the principle of inertia. Therefore, by repeating the above operations, the piezoelectric plate 533 can be controlled to vibrate in a reciprocating manner, and the vibration frequency of the resonant chamber 56 can be controlled to be approximately the same as the vibration frequency of the piezoelectric plate 533, so as to generate the helmholtz resonance effect, thereby achieving high-speed and large-volume fluid transmission.

The air hole sheet 51 is fixed and positioned, so that a gap is defined on the side edge of the air hole sheet 51 to surround the air hole sheet for air circulation, an air flow chamber 57 is formed between the bottom of the air hole sheet 51, a resonance chamber 56 is formed between the actuating body 53, the cavity frame 52 and the suspension sheet 511, the actuating body 53 is driven to drive the air hole sheet 51 to resonate, the suspension sheet 511 of the air hole sheet 51 generates reciprocating vibration displacement, and the air-entraining body enters the air flow chamber 57 through the gap and is discharged.

Referring to fig. 6 to 7C, the fluid transfer device 31 is a micro-electromechanical pump 6, and the micro-electromechanical pump 6 is manufactured by a semiconductor process, including: a substrate 61, a first chamber 62, a resonator plate 63, an actuator plate 64, a piezoelectric element 65, an exit plate 66, and an entrance plate 67. Wherein the first chamber 62 is formed by etching the substrate 61; a resonator plate 63, which is formed by etching a hollow hole 63a and a movable portion 63b stacked on the substrate 61, wherein the movable portion 63b is a flexible structure formed by the portion of the resonator plate 63 not fixed on the substrate 61; a spacer layer 60 that is applied to a portion of the resonator plate 63 other than the movable portion 63 b; an actuator plate 64, which is formed by etching a floating portion 64a, an outer frame portion 64b and a plurality of through holes 64c, and is stacked on the spacer layer 60, wherein the floating portion 64a is connected with the outer frame portion 64b, and is suspended and supported by the plurality of through holes 64c between the floating portion 64a and the outer frame portion 64b, and the through holes 64c are used for fluid communication, and the actuator plate 64 and the resonator plate 63 define a second chamber 68; a piezoelectric element 65 coated and stacked on the floating portion 64a of the actuator plate 64; and an outlet plate 66, which is stacked on the outer frame portion 64b of the actuator plate 64 by forming a third chamber 69 and an outlet hole 66a through an etching process, so that the third chamber 69 corresponds to the suspension portion 64a and the outer frame portion 64b of the actuator plate 64, and the outlet hole 66a is communicated with the third chamber 69; and an inlet plate 67 stacked under the substrate 61 by forming at least one inlet hole 67a by an etching process; therefore, the fluid transmission device 31 is driven by the piezoelectric element 65 to drive the actuating plate 64 to generate a reciprocating vibration displacement, so as to draw the fluid into the first chamber 62 through the inlet hole 67a, and then generate a resonant transmission fluid through the hollow hole 63a of the resonance plate 63, so that the fluid is transmitted and flows through the actuating plate 64 and the movable portion 63b of the resonance plate 63.

When the fluid transfer device 31 is in an unactuated state (i.e., an initial state), and when the piezoelectric element 65 is subjected to a voltage, the piezoelectric element deforms, so as to drive the actuating plate 64 to perform reciprocating vibration in a vertical direction, the floating portion 64a of the actuating plate 64 vibrates upwards, so as to cause the volume of the second chamber 68 to increase and the pressure to decrease, and then the fluid enters from the inlet hole 67a of the inlet plate 67 in compliance with the external pressure, collects at the first chamber 62, and then flows upwards into the second chamber 68 through the hollow hole 63a of the resonance plate 63, which is arranged corresponding to the first chamber 62; then, the vibration of the floating portion 64a of the actuating plate 64 drives the resonance plate 63 to resonate, so that the movable portion 63b vibrates upwards, and the floating portion 64a of the actuating plate 64 vibrates downwards at the same time, which causes the movable portion 63b of the resonance plate 63 to stick and abut against the lower portion of the floating portion 64a of the actuating plate 64, at this time, the communication gap between the hollow hole 63a of the resonance plate 63 and the second chamber 68 is closed, the second chamber 68 is compressed to become smaller in volume and increased in pressure, the third chamber 69 is increased in volume and decreased in pressure, and a pressure gradient is formed, so that the fluid in the second chamber 68 is pressed to flow to both sides, and flows into the third chamber 69 through the plurality of through holes 64c of the actuating plate 64; the floating portion 64a of the actuating plate 64 continues to vibrate downward and drives the movable portion 63b of the resonator plate 63 to vibrate downward, so as to further compress the second chamber 68 and make most of the fluid flow into the third chamber 69 for temporary storage, and thus, the pumping fluid is generated from the inlet hole 67a to the outlet hole 66a for discharge, thereby achieving the fluid transfer.

The piezoelectric element 65 is driven to drive the actuating plate 64 to generate reciprocating vibration displacement, so as to draw the gas into the first chamber 62 through the inlet hole 67a, and generate resonance transmission gas through the actuating plate 64 and the movable portion 63b of the resonator plate 63 via the hollow hole 63a of the resonator plate 63.

In the blood sampling and detecting device, the speed and the dosage of the blood transmission and flowing during the blood sampling are controlled by the fluid transmission control system 3, so that the blood sampling and detecting are carried out in a mechanical mode, meanwhile, the reservoir 2 for storing the blood is a combined and detachable structure, and the reservoir 2 for storing the blood is detachably provided and then is sent to a sampling and detecting unit for medical care personnel to use. Therefore, the invention can completely solve the defect that the traditional manual blood drawing operation cannot achieve quantification and constant speed, and effectively reduce the discomfort of patients.

Claims (12)

1. A blood sampling and detecting device is suitable for performing swabbing sampling and detecting on blood of a human body, and comprises:

at least one micro needle for inserting into a blood vessel of a human body to perform blood collection and examination;

a reservoir, which is communicated with the micro needle and is used for collecting the blood, and comprises a suction tube which is communicated with the inner space of the reservoir;

a fluid transmission control system comprises a fluid transmission device, a driving controller and a power supply, wherein the fluid transmission device is arranged and communicated with one end of the suction pipe and can pump the inner space of the storage device in an operating mode, the power supply provides power for the driving controller to start the fluid transmission device, the fluid transmission device is driven to control the inner space of the storage device to form pressure difference, and blood of the micro needle inserted into the blood vessel is pumped and stored in the storage device.

2. The blood collection and examination device according to claim 1, wherein the micro needle comprises a hollow soft needle and a solid fine needle, the solid fine needle is sleeved in the hollow soft needle and slightly exposed to penetrate the blood vessel of the human body, the hollow soft needle is smoothly inserted into the blood vessel, and the hollow soft needle is connected to the reservoir after the solid fine needle is withdrawn.

3. The blood collection and testing device of claim 2, wherein the length of the hollow soft needle is 1000-2000 microns (μm), and the diameter of the hollow hole is 10-1000 microns (μm).

4. The blood sampling device of claim 1, comprising a plurality of microneedles integrally and intermittently disposed at one side of the reservoir for insertion into the blood vessel of a human body for performing the blood sampling.

5. The blood sampler of claim 4 wherein the microneedle has a length of 1000 and 2000 microns (μm) and a hollow pore size of 10-1000 microns (μm).

6. The blood collection and testing device of claim 1, wherein a blood sensor is disposed outside the reservoir for detecting the presence of blood in the reservoir to determine whether the microneedle is properly inserted into the blood vessel.

7. The blood sampler of claim 1 wherein a connector is provided between the reservoir and the suction tube for detachably connecting or coupling the reservoir to the suction tube.

8. The blood sampler of claim 1 wherein the microneedle, reservoir and aspiration tube are disposable.

9. The blood sampler of claim 1, wherein the fluid transfer device of the fluid transfer control system is a gas pump comprising:

the inflow plate is provided with at least one inflow hole, at least one bus groove and a confluence chamber, wherein the inflow hole is used for introducing a gas, the inflow hole correspondingly penetrates through the bus groove, and the bus groove is converged to the confluence chamber, so that the gas introduced by the inflow hole can be converged to the confluence chamber;

a resonance sheet, which is connected on the flow inlet plate and is provided with a hollow hole, a movable part and a fixed part, wherein the hollow hole is positioned at the center of the resonance sheet and corresponds to the confluence chamber of the flow inlet plate, the movable part is arranged at the area around the hollow hole and opposite to the confluence chamber, and the fixed part is arranged at the outer peripheral part of the resonance sheet and is attached on the flow inlet plate; and

the piezoelectric actuator is jointed on the resonator plate and correspondingly arranged, and comprises a suspension plate, an outer frame, at least one bracket and a piezoelectric element, wherein the suspension plate can be bent and vibrated;

the resonance piece and the movable part of the resonance piece generate resonance transmission of the gas, wherein a cavity space is arranged between the resonance piece and the piezoelectric actuator, so that when the piezoelectric actuator is driven, the gas is guided in from the inflow hole of the inflow plate, is collected into the confluence cavity through the bus groove, and then flows through the hollow hole of the resonance piece.

10. The blood sampler of claim 9, wherein the gas pump further comprises a first insulating plate, a conducting plate and a second insulating plate, wherein the flow inlet plate, the resonator plate, the piezoelectric actuator, the first insulating plate, the conducting plate and the second insulating plate are sequentially stacked and combined.

11. The blood sampler of claim 1, wherein the fluid transfer device of the fluid transfer control system is a box-type gas pump comprising:

the air injection hole piece comprises a suspension piece and a central hole, the suspension piece can be bent and vibrated, and the central hole is formed in the central position of the suspension piece;

a cavity frame bearing and superposed on the suspension plate;

an actuator, which is formed by a piezoelectric carrier plate, an adjusting resonance plate and a piezoelectric plate which are sequentially superposed and is loaded and superposed on the cavity frame so as to receive voltage and generate reciprocating bending vibration;

an insulating frame bearing the piezoelectric carrier plate superposed on the actuating body; and

a conductive frame, which is arranged on the insulating frame in a bearing and stacking manner;

the actuating body, the cavity frame and the suspension plate form a resonance chamber therebetween, and the actuating body is driven to drive the jet hole plate to resonate so as to generate reciprocating vibration displacement of the suspension plate of the jet hole plate, so that the gas is drawn into the airflow chamber through the gap and then discharged.

12. The blood collection and testing device of claim 1, wherein said fluid transfer device of said fluid transfer control system is a microelectromechanical pump fabricated by semiconductor processes, comprising:

a substrate;

a first chamber fabricated by an etching process on the substrate;

a resonator plate, which is stacked on the substrate by forming a hollow hole and a movable portion by etching process, wherein the movable portion is a flexible structure formed by the part of the resonator plate not fixed on the substrate;

a spacer layer coating a portion of the resonator plate other than the movable portion;

an actuating plate, which is stacked on the spacing layer by making a suspension part, an outer frame part and a plurality of gaps by etching process, wherein the suspension part is connected with the outer frame part and is supported in a suspension way by a plurality of gaps between the suspension part and the outer frame part, the gaps are used for gas circulation, and a second chamber is defined by the actuating plate and the resonating plate;

a piezoelectric element coated and overlapped on the suspension part of the actuating plate; and

an outlet plate, which is stacked on the outer frame of the actuating plate to form a third chamber and an outlet hole by etching process, so that the third chamber corresponds to the suspension part and the outer frame part of the actuating plate, and the outlet hole is communicated with the third chamber; and

an inlet plate, which is stacked under the substrate by etching to form at least one inlet hole;

the piezoelectric element drives the actuating plate to generate reciprocating vibration displacement so as to draw the gas into the first chamber through the inlet hole, and the gas is transmitted through the hollow hole of the resonance plate by the actuating plate and the movable part of the resonance plate through resonance.

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