CN115057016B

CN115057016B - Pollution prevention split charging device and method for radioactive particles and application of pollution prevention split charging device and method

Info

Publication number: CN115057016B
Application number: CN202210646403.8A
Authority: CN
Inventors: 杜泽天; 黄曾�; 田佳乐; 李刚; 郝晋; 杨宇川; 阳国桂
Original assignee: Guotong Chengdu New Drug Technology Co ltd; Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics
Current assignee: Guotong Chengdu New Drug Technology Co ltd; Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics
Priority date: 2022-06-09
Filing date: 2022-06-09
Publication date: 2023-06-16
Anticipated expiration: 2042-06-09
Also published as: CN115057016A

Abstract

A dispensing apparatus for radioactive particles, a dispensing method and use thereof, the dispensing apparatus comprising: a carrying platform configured to hold the sub-packaging containers; the hopper comprises a containing part and a neck part positioned below the containing part and communicated with the containing part, the neck part is configured to contain radioactive particles to be packaged, an opening is arranged at the end part of the neck part far away from the containing part, and the opening is configured to be aligned with the packaging container; a screen disposed in the neck and configured to receive the radioactive particles to be packaged; a blocker disposed below the screen of the neck and configured to have an open state and a closed state for blocking missing radioactive particles when the blocker is in the closed state and falling down the neck when the blocker is in the open state; and the vibration device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction.

Description

Pollution prevention split charging device and method for radioactive particles and application of pollution prevention split charging device and method

Technical Field

The disclosure relates to the technical field of radioactive particle split charging, in particular to an anti-pollution split charging device and method for radioactive particles and application of the anti-pollution split charging device and method.

Background

China is the major country of liver diseases, the incidence rate of liver cancer is still the first worldwide, 20 liver cancer cases are newly increased every day worldwide, and the incidence rate of liver cancer is 10 in China. The radioactive embolism based on 90Y (yttrium 90) particles is an effective means for treating primary liver cancer at present, can remarkably prolong the life cycle of patients and improve the life quality. For a few patients, 90Y particle therapy can degrade tumors, allowing for surgical resection or liver transplantation. Primary liver cancer is the fifth leading in the incidence of malignant tumors in the world, the third leading in the death rate of tumors, and more than 60% of patients have lost the opportunity to receive curative treatment (liver resection, liver transplantation) at the time of liver cancer diagnosis.

The 90Y particles are a low-toxicity and targeted liver cancer preparation, and consist of millions of particles carrying radioactivity 90Y, doctors inject the radioactive particles (with the diameter of 20-30 mu m) into hepatic arteries through a catheter intervention method, the particles enter corresponding liver tissues through arterial blood flow and are captured in priority and are retained in peripheral blood vessels of tumors, rays are continuously generated to kill the tumor tissues, so that the focus receives local high-dose radiotherapy and partial embolism effect is generated, and meanwhile, the influence on non-tumor tissues and other organs is small, so that high-selectivity and high-efficiency killing of liver cancer cells is realized.

The average particle diameter of the 90Y particles is 20-30 mu m, and as a radioactive powder for emitting beta rays, the split charging operation is carried out in an operation box with radiation protection, the charging amount is usually 20-500 mg, and the split charging precision is required to be within 5%. Even if the radioactive powder is carried out in the radiation protection operation box, the radioactive powder needs to be prevented from scattering, so that the pollution to the related equipment in the operation box is avoided, and particularly when the split charging process is finished, the residual radioactive powder still exists and can scatter from the split charging path to the related equipment in the box to cause the pollution. There is no mature solution for how to avoid scattering of radioactive particles after automated sub-packaging is completed.

Disclosure of Invention

Some embodiments of the present disclosure provide an anti-contamination dispensing device for radioactive particles, comprising:

a carrying platform configured to hold the sub-packaging containers;

a hopper comprising a receiving portion and a neck portion positioned below the receiving portion in communication with the receiving portion, the neck portion configured to receive radioactive particles to be dispensed, an end of the neck portion remote from the receiving portion being provided with an opening configured to be aligned with the dispensing container;

a screen disposed in the neck configured to receive the radioactive particles to be packaged;

A blocker disposed below the screen of the neck and configured to have an open state and a closed state for blocking missing radioactive particles when the blocker is in the closed state and falling along the neck when the blocker is in the open state;

the vibration device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction;

wherein, in response to vibrating device stop work, the screen cloth prevents the radioactive particles passes through the neck, and the separation ware is closed in order to separate from the screen cloth is missed the radioactive particles, in response to vibrating device work, the separation ware is opened and the radioactive particles pass the screen cloth, keep away from through the neck the opening of holding portion partial shipment to in the partial shipment container.

In some embodiments, the barrier comprises a rotatable first barrier and a rotatable second barrier, the first barrier and the second barrier end sealingly interfacing when the first barrier and the second barrier are rotated to a closed position, the barriers being in a closed state; when the first and second shutters are rotated to an open position, the first and second shutters extend downwardly along the neck, the shutters being in an open state.

In some embodiments, the first and second barriers are each planar or arcuate.

In some embodiments, the first and second blockers are cambered and have the same arc as the neck so that when the first and second blockers are rotated to an open position, the first and second blockers conform to the inner wall of the neck and extend downward.

In some embodiments, the first and second stoppers are asymmetric in structure, and the closed position is located in a non-axial position of the neck when the first and second stoppers are rotated to the closed position.

In some embodiments, the end portions of the first barrier and the second barrier that are in sealing abutment are each provided with a flexible portion.

In some embodiments, the flexible portion comprises any one or combination of a brush, an elastic rubber, a fabric.

In some embodiments, the dispensing device further comprises:

a hopper, arranged below the hopper, configured to be movable in a first direction and/or a second direction,

Wherein the funnel includes an inlet and an outlet, the end that the neck was kept away from the holding portion inserts from the inlet in the funnel, responding to the funnel is kept away from along the second direction the hopper removes, the end that the outlet of funnel is located inserts in the partial shipment container, responding to the funnel is along the second direction towards the hopper removes, the end that the outlet of funnel is located is taken out from in the partial shipment container.

In some embodiments, the funnel further comprises a solenoid valve disposed above the outlet, the solenoid valve preventing omission of the radioactive particles when closed.

In some embodiments, the dispensing device further comprises:

and the waste tray is arranged on the bearing table and is used for accommodating the sub-packaging containers and receiving the missed radioactive particles.

In some embodiments, the waste tray includes a recess for receiving the dispensing container.

In some embodiments, the carrier includes a weight sensor that weighs the racking container in real time to obtain the weight of the radioactive particles loaded into the racking container.

In some embodiments, the material of the hopper comprises one or a combination of glass, plastic or aluminum, and the inner wall of the hopper is provided with an aluminum foil layer.

Some embodiments of the present disclosure provide an anti-pollution packaging method for radioactive particles, using the packaging device according to any of the embodiments described above, the packaging method comprising:

placing a waste tray on the carrying table;

placing the sub-packaging container in a groove of the waste tray;

moving the funnel in a first direction and/or a second direction, enabling the neck to be far away from the opening of the containing part and to be inserted into the funnel from the funnel inlet, and enabling the end part where the outlet of the funnel is positioned to be inserted into the sub-packaging container;

opening the barrier to rotate the barrier from a closed state to an open state;

and controlling the vibration device to vibrate until the amount of the radioactive particles in the sub-packaging container meets the sub-packaging standard.

Some embodiments of the present disclosure also provide a use of a racking device for racking radiopharmaceuticals, the racking device comprising a racking device as described in any of the above.

Compared with the related art, the method has at least the following technical effects:

the anti-pollution partial shipment device of radioactive particles that this disclosed embodiment provided has avoided the partial shipment to finish the back omission of radioactive particles through addding the separation ware, and is specific, sets up the separation ware in the screen cloth below of hopper neck to control it is in open state and closed state, can respond vibrating device stop work, the screen cloth prevents radioactive particles passes through the neck, just the separation ware is closed in order to separate follow the separation of screen cloth is omitted radioactive particles responds vibrating device work, the separation ware is opened just radioactive particles passes the screen cloth, via the neck is kept away from the opening partial shipment of holding portion arrives in the partial shipment container. In addition, through the technical means such as setting up the waste tray, setting up solenoid valve in the funnel, further avoided the partial shipment to finish the omission of back radioactive particle.

Drawings

In order to more clearly illustrate the embodiments of the present disclosure or the technical solutions in the prior art, a brief description will be given below of the drawings required for the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are some embodiments of the present disclosure, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1A is a schematic diagram of a racking system according to some embodiments of the present disclosure;

FIG. 1B is a schematic diagram of a dispensing apparatus for radioactive particles according to some embodiments of the present disclosure;

FIG. 2 is an enlarged perspective view of region M of FIG. 1B;

FIG. 3 is a flow chart of a racking method provided in an embodiment of the present disclosure;

fig. 4 is a schematic structural view of a neck receiving portion provided in some embodiments of the present disclosure;

FIG. 5 is a schematic view of a hopper and funnel combination provided in some embodiments of the present disclosure;

FIG. 6 is a flow chart of a racking method provided in some embodiments of the present disclosure;

FIG. 7 is a schematic side view of a closure in a closed state of a barrier provided in some embodiments of the present disclosure;

FIG. 8 is a schematic top view of a closed state of a barrier provided in some embodiments of the present disclosure;

Fig. 9 is a schematic top view of a closed state of a barrier provided in some embodiments of the present disclosure;

FIG. 10 is a schematic side view of a waste tray provided in some embodiments of the present disclosure;

FIG. 11 is a flow chart of a racking method provided in some embodiments of the present disclosure;

FIG. 12 is a schematic diagram of a control structure of a vibration device according to some embodiments of the present disclosure;

FIG. 13 is a flow chart of a racking method provided in some embodiments of the present disclosure;

FIG. 14 is a schematic view of a split charging liquid level positioning structure provided in some embodiments of the present disclosure;

fig. 15 is a flow chart of a racking method provided in some embodiments of the present disclosure.

Detailed Description

For the purpose of promoting an understanding of the principles and advantages of the disclosure, reference will now be made in detail to the drawings, in which it is apparent that the embodiments described are only some, but not all embodiments of the disclosure. Based on the embodiments in this disclosure, all other embodiments that a person of ordinary skill in the art would obtain without making any inventive effort are within the scope of protection of this disclosure.

The terminology used in the embodiments of the disclosure is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. As used in this disclosure of embodiments and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise, the "plurality" generally includes at least two.

It should be understood that the term "and/or" as used herein is merely one relationship describing the association of the associated objects, meaning that there may be three relationships, e.g., a and/or B, may represent: a exists alone, A and B exist together, and B exists alone. In addition, the character "/" herein generally indicates that the front and rear associated objects are an "or" relationship.

It should also be noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a product or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such product or apparatus. Without further limitation, an element defined by the phrase "comprising" does not exclude the presence of other like elements in a commodity or device comprising such element.

In the medical field, the packaging of non-radioactive particles, such as non-radioactive powders, particles, etc., is usually performed by a screw packaging device, but such a screw packaging device cannot be directly used for packaging of radioactive powders. The following reasons are mainly:

1. The dispensing amount of the screw dispensing machine is generally more than 100mg, and it is difficult to ensure the dispensing accuracy for the dispensing amount of less than 100 mg.

2. The radioactive particles have good uniformity of particle size and good fluidity, if a screw rod racking machine is adopted, the problems of particle leakage of different degrees can exist, the inaccurate loading and the radioactive particles are scattered, and the radioactive particles can be broken, so that the quality of medicines is affected.

3. The screw racking device does not take into account the need for resistance to ionizing radiation, and the logic circuits and devices are directly exposed to the ionizing radiation environment, resulting in equipment failure.

4. The screw split charging device does not consider the requirement of small total split charging amount of the radioactive medicines, has huge equipment and is inconvenient for radiation protection.

In the prior art, the following technical problems exist in respect of the split charging of radioactive particles:

1. when the raw material bottle grabbing manipulator turns over and radioactive particles are dumped into the sub-packaging equipment, powder may not be dumped into the sub-packaging equipment due to inaccurate positioning and falls to the bottom of the box chamber; or because of a certain negative pressure in the box, part of the granular powder is taken away by the airflow;

2. in the particle vibration split charging process, due to certain negative pressure in the box chamber, part of particle powder is taken away by airflow from an upper side opening of split charging equipment and does not flow out from a lower side outlet, so that box type pollution is caused.

To at least one of the problems among the related art as described above, for satisfying medical radioactive particle's partial shipment demand, realize the accurate partial shipment to radioactive particle, can avoid the pollution of radioactive particle in the partial shipment process simultaneously, this disclosure provides a radioactive particle's partial shipment device, includes: a carrying platform configured to hold the sub-packaging containers; the hopper is funnel-shaped and comprises a containing part and a neck part which is positioned below the containing part and communicated with the containing part, the neck part is configured to contain radioactive particles to be packaged, an opening is formed in the end part, away from the containing part, of the neck part, the opening is aligned with the packaging container, the diameter of the containing part is larger than that of a raw material bottle body for containing the radioactive particles, and the neck part is of a sufficient length so that after the radioactive particles to be packaged are poured into the neck part, the radioactive particles to be packaged are positioned below the junction of the containing part and the neck part; a screen disposed in the neck; the vibrating device is connected with the hopper, the hopper and the screen are configured and driven to vibrate in a first direction, the vibrating device stops working, the screen stops radioactive particles from passing through the neck, the vibrating device responds to working, the radioactive particles pass through the screen, the radioactive particles are separated into the separated containers through the opening of the neck, which is far away from the accommodating part, and the radioactive particles filled into the hopper are separated into the separated containers through the screen in a vibrating mode, so that the accurate separation of the radioactive particles is realized.

Alternative embodiments of the present disclosure are described in detail below with reference to the drawings.

Fig. 1A is a schematic structural diagram of a racking system according to some embodiments of the present disclosure. As shown in fig. 1A, the present disclosure provides a dispensing system 1000 for dispensing a radioactive particle, such as a radiopharmaceutical or a radioactive microsphere, for dispensing a radiopharmaceutical having radioactivity, such as a radioactive particle, a radioactive powder, or the like, from one large source container into a plurality of small dispensing containers. The racking system 1000 includes a racking station 1, a cap removal/capping station 3, and a racking container placement station 2. The dispensing station 1 performs dispensing of the radioactive particles and dispenses the radioactive particles into dispensing containers. The cover taking/buckling operation is performed at the cover taking/buckling station 3, specifically, the cover body in the sub-packaging container is picked up before the sub-packaging operation, and the cover body is buckled into the sub-packaging container after the sub-packaging operation. The sub-packaging container placing station 2 is used for placing sub-packaging containers before and after sub-packaging operation, and the sub-packaging containers move among the three stations to execute operations at the stations.

The dispensing station 1 is provided with a dispensing device for radioactive particles, and fig. 1B is a schematic structural diagram of a dispensing device for radioactive particles according to some embodiments of the present disclosure. As shown in fig. 1B, the racking device 100 includes a carrying table 10, the carrying table 10 being configured to place racking containers 20. The dispensing container 20 is used to hold the dispensed radioactive particles including, but not limited to, radioactive glass particles, radioactive particulate resin particles. The dispensing container 20 is, for example, a penicillin bottle. The dispensing device 100 further comprises a hopper 30, for example in the form of a funnel, comprising a receiving portion 31 and a neck portion 32 located below the receiving portion 31 in communication with said receiving portion 31. The hopper 30 is configured to receive the radioactive particles to be dispensed. The end of the neck 32 remote from the receiving portion 31 is provided with an opening configured to be aligned with the dispensing container 20 to dispense the radioactive particles to be dispensed, contained in the hopper 30, into the dispensing container 20.

Fig. 2 is an enlarged perspective view of the M region in fig. 1B. As shown in fig. 1B and 2, a screen 321 is disposed in the neck 32 of the hopper 30, and a plurality of meshes are uniformly distributed on the screen 321, where the pore diameter of the mesh is slightly larger than the particle diameter of the radioactive particles contained in the hopper 30, for example, the pore diameter of the mesh is 1 to 3 times the particle diameter of the radioactive particles. In some embodiments, for example, when the radioactive particles are dispensed using the dispensing apparatus 100, the radioactive particles have a particle size of 20 to 30 μm and the mesh openings of the screen 321 are 22 to 90 μm. The radioactive particles are charged the same, the radioactive particles contained in the hopper 30 repel each other due to the charge, and the radioactive particles located at the screen 321 do not pass through the screen 321 having mesh apertures similar to the radioactive particles due to the charge interaction.

Referring to fig. 1B, the dispensing device 100 further includes a vibration device 40, where the vibration device 40 is connected to the hopper 30 and configured to drive the hopper 30 and the screen 321 to vibrate in a first direction, for example, a horizontal direction. Specifically, as shown in fig. 1B, the vibration device 40 includes a driver 41 and a vibration block 42, the driver 41 being provided on a bracket of the racking device for driving the vibration block 42 to perform a vibration operation. The vibrating mass 42 is coupled, e.g., snapped, to the hopper 30 and is configured to support the hopper 30. In some embodiments, the vibrating mass 42 has a fixing through hole 421, at least a portion of the neck 32 of the hopper 30 passes through the fixing through hole 421 so that the hopper 30 is fixedly supported by the vibrating mass 42, and an inner wall of the fixing through hole 421 has a slope with respect to a vertical direction, which matches the slope of the neck 32 of the hopper 30 with respect to the vertical direction, in which case the hopper 30 can be conveniently mounted on the vibrating mass 42 or dismounted from the vibrating mass 42, facilitating replacement of the hopper 30, facilitating cleaning or one-time use of the hopper 30 in direct contact with radioactive particles, and meeting GMP specifications for pharmaceutical production.

When the dispensing device 100 is used to dispense the radioactive particles, the screen 321 prevents the radioactive particles from passing through the neck 32 of the hopper 30 in response to the vibration device 40 stopping. In response to the vibration means 40 being operated, the radioactive particles pass through the screen 321 and are dispensed into the dispensing container 20 through the opening of the neck 32 away from the receiving portion 31. Specifically, as described above, in the state where the screen 321 and the hopper 30 are stationary, since the aperture of the mesh is slightly larger than the radioactive particles contained in the hopper 30, the screen 321 can support the radioactive particles under the action of the charges carried by the radioactive particles, and the radioactive particles located at the screen 321 do not pass through the screen 321 having apertures similar to the apertures of the radioactive particles. When the screen 321 and the hopper 30 vibrate under the driving of the vibration device 40, the balance among the acting force of the electric charges, the gravity of the radioactive particles and the supporting force of the screen 321 on the radioactive particles is destroyed, the radioactive particles at the screen 321 can relatively slowly pass through the mesh of the screen 321 under the action of gravity, and are packaged into the packaging container 20 through the opening of the neck 32 at the end of the neck portion away from the containing portion 31.

The split charging device adopting the vibration mode can realize accurate control on the split charging of radioactivity, and whether radioactive particles flow out of the hopper 30 is controlled by controlling whether the vibration device 40 works or not. The radioactive particles are packaged by the packaging device, so that the high-precision packaging requirement can be met, and the packaging precision lower than 5% can be realized for the packaging quantity of 20-500 mg.

And adopt above-mentioned partial shipment device to realize sieving when carrying out the partial shipment to the radioactive particle, further controlled the particle diameter of granule, removed the large granule impurity in the granule of waiting to split into. The split charging process can not cause mechanical extrusion of the particles to be split charged, the particles are not destroyed, and the product quality is effectively ensured.

In the above embodiment, the radioactive particles are exemplified by glass particles, and in other embodiments, the particle size of the radioactive particles to be dispensed is 20 to 80 μm, and the pore size of the screen is, for example, 20 to 200 μm, preferably 30 to 100 μm. Therefore, the radioactive particles can be prevented from leaking when the vibrating device does not work, and the hopper slowly releases the radioactive particles when the vibrating device works.

In some embodiments, the speed and accuracy of dispensing can be affected by the area of the screen. In order to ensure the speed and precision of 20-500mg granule split charging, the area of the screen is not more than 10cm ² Preferably not greater than 1cm ² 。

In some embodiments, to reduce the bremsstrahlung generated by the beta rays released by the radioactive particles, the hopper material in contact with the radioactive particles may be one or a combination of glass, plastic or aluminum, preferably a transparent plastic material. Further, to reduce the electrostatic adsorption effect between the transparent plastic material and the radioactive particles and increase the yield of sub-packaging, in some embodiments, an aluminum foil layer may be further disposed on the inner wall of the plastic hopper.

In some embodiments, the hopper 30 and the screen 321 therein are of an integrated design, and after a predetermined number of batches are dispensed, the hopper 30 and the screen 321 therein may be replaced in their entirety, meeting GMP specifications.

In some embodiments, the carrier 10 includes a sensor that monitors in real time the amount of the radioactive particles loaded into the dispensing container 20. The sensor is for example a weight sensor, a radioactivity sensor. The sensor is disposed in the loading table 10, for example, and a circuit portion electrically connected to the sensor is also disposed in the loading table 10 and is separated from the surface of the loading table 10 contacting the dispensing container 20 as far as possible, so that the radioactive particles in the dispensing container 20 are prevented from adversely affecting the circuit portion. In other embodiments, radiation protection devices may also be provided around the circuit portion to shield the circuit portion from radiation from the radioactive particles, ensuring proper operation of the circuit portion.

In some embodiments, a sensor, such as a weight sensor, weighs the dispensing container in real time to obtain the weight of the radioactive particles loaded into the dispensing container 20. The vibration device 40 is controlled based on the weight of the radioactive particles loaded in the dispensing container 20 obtained in real time, thereby achieving accurate dispensing of the radioactive particles.

In the dispensing apparatus 100 as described above, the rate at which radioactive particles, such as 90Y radioactive particles, flow out of the hopper 30 when the vibration apparatus 40 is in operation, is related to the vibration frequency F and amplitude a of the vibration apparatus 40. The applicant has found that, with the amplitude a of the vibration means 40 unchanged, the higher the vibration frequency F of the vibration means 40, the greater the rate of outflow of the radioactive particles from the hopper 30, and the lower the vibration frequency F of the vibration means 40, the lower the rate of outflow of the radioactive particles from the hopper 30. When the vibration frequency F of the vibration device 40 is unchanged, the larger the amplitude a of the vibration device 40 is, the larger the rate at which the radioactive particles flow out of the hopper 30 is, and the smaller the amplitude a of the vibration device 40 is, the larger the rate at which the radioactive particles flow out of the hopper 30 is.

The discharge rate of the radioactive particles is too slow to affect the packing efficiency, and the discharge rate of the radioactive particles is too fast to affect the packing precision. In order to achieve both of the dispensing efficiency and the dispensing accuracy, the inventors have performed frequency conversion or amplitude variation control of the vibration device 40 to achieve better dispensing of the radioactive particles when the radioactive particles are dispensed by using the dispensing device 100.

In some embodiments, during dispensing of the radioactive particles using the dispensing apparatus 100 described above, accurate dispensing of the radioactive particles is achieved by controlling the frequency of vibration of the vibration apparatus to decrease as the weight of the radioactive particles loaded into the dispensing container increases.

The inventor obtains a scheme for controlling the vibration frequency of the vibration device to obtain the split charging effect of excellent radioactive particles through research and calculation and a large number of experiments. The method comprises the following steps:

the vibration frequency F of the vibration device satisfies the following formula:

wherein W is _D ＝W _S -W _R ，W _S A standard weight, W, of the radioactive particles planned to be filled in the sub-packaging container _R The weight of the radioactive particles contained in the dispensing container measured by the weight sensor.

The following are illustrative of some examples taken by the inventors in experiments:

in the following examples and comparative examples, the dispensing apparatus 100 shown in FIG. 1B was used, the dispensing target was 90Y radioactive particles, the standard dispensing amount was 100mg, and the amplitude A of the vibration apparatus 40 was 300. Mu.m.

Example 1

Comparative example 1

Comparative example 2

F＝W _D Hz

TABLE 1

As can be seen from table 1, the dispensing time of example 1 and comparative example 1 is shorter than that of comparative example 2, the dispensing accuracy of example 1 is higher than that of comparative example 1, and the dispensing accuracy of example 1 and comparative example 2 is higher than that of comparative example 1, and the dispensing time of example 1 is shorter. In example 1, the dispensing time and the dispensing accuracy can be both achieved compared to comparative examples 1 and 2.

In some embodiments, the amplitude of the vibration device decreases as the weight of the radioactive particles contained in the dispensing container increases during dispensing of the radioactive particles using the dispensing device 100 described above to achieve dispensing of the radioactive particles.

The inventor obtains a scheme for controlling the amplitude of the vibration device to obtain the split charging effect of the excellent radioactive particles through research and calculation and a large number of experiments. The method comprises the following steps:

the amplitude a of the vibration device satisfies the following formula:

in the following examples and comparative examples, the dispensing apparatus 100 shown in FIG. 1B was used, the dispensing target was 90Y radioactive particles, the standard dispensing amount was 100mg, and the frequency F of the vibration apparatus 40 was 100Hz.

Example 2

The amplitude a of the vibration device satisfies the following formula:

Comparative example 3

wherein W is _D ＝W _S -W _R ，W _S A standard weight, W, of the radioactive particles planned to be filled in the sub-packaging container _R For the weight of the radioactive particles contained in the dispensing container measured by the weight sensorAmount of the components.

Comparative example 4

The vibration frequency A of the vibration device satisfies the following formula:

A＝5W _D μm

TABLE 2

As can be seen from table 2, the dispensing accuracy of example 2 and comparative examples 3 and 4 differ greatly, but the dispensing time of example 2 is significantly due to comparative examples 3 and 4. In example 2, the dispensing time and the dispensing accuracy can be both compared to comparative examples 3 and 4.

In the foregoing embodiment, the dispensing is performed by controlling the vibration device 40 to operate until the weight of the radioactive particles in the dispensing container 20 satisfies the requirement based on the real-time monitoring of the weight of the radioactive particles in the dispensing container 20, and in other embodiments, the dispensing may be performed by controlling the vibration device 40 to operate until the radioactivity of the radioactive particles in the dispensing container 20 satisfies the requirement based on the real-time monitoring of the radioactivity of the radioactive particles in the dispensing container 20.

In some embodiments, referring to fig. 1B, the racking device 100 further includes a funnel 50, the funnel 50 being disposed below the hopper 30 and configured to be movable in a second direction, such as a vertical direction. The funnel 50 comprises an inlet from which the end of the neck 32 of the funnel 30 remote from the receptacle 31 is inserted into the funnel 50, and an outlet from which the funnel 50 is positioned is inserted into the dispensing container 20 in response to movement of the funnel 50 in a second direction away from the funnel 30, and an outlet from which the funnel 50 is positioned is withdrawn from the dispensing container 20 in response to movement of the funnel 50 in a second direction towards the funnel 30.

The funnel 50 can be used as a transmission channel of radioactive particles in the packaging process, when the packaging device 100 is adopted to perform packaging of the radioactive particles, the end part, away from the accommodating part 31, of the neck 32 of the funnel 30 is inserted into the funnel 50 from the inlet, the end part, where the outlet of the funnel 50 is located, is inserted into the packaging container 20, and the radioactive particles in the funnel 30 can be packaged into the packaging container 20 through the funnel 50, so that leakage of the radioactive particles in packaging is avoided. The aperture of the inlet of the funnel 50 needs to be large enough, so that the inner wall of the funnel 50 is not contacted with the outer wall of the neck 32 of the funnel 30 in the process of moving the funnel along the second direction and under the condition that the funnel 30 vibrates under the driving of the vibration device 40, and the split charging operation of the split charging device is prevented from being influenced.

When the dispensing operation is completed for one of the dispensing containers 20, the vibration device 40 stops vibrating, the hopper 50 moves toward the hopper 30 in the second direction, the end portion of the outlet of the hopper 50 is drawn out of the dispensing container 20, the dispensing container 20 is taken out of the loading table 10 by a robot arm, for example, to enter the next process, and the robot arm picks up another empty dispensing container 20 and places it on the loading table 10. The opening of the dispensing container 20 is aligned with the outlet of the hopper 50, the hopper 50 is moved in a second direction away from and towards the hopper 30, the end of the hopper 50 at which the outlet is located is inserted into the dispensing container 20, and the vibrating means 40 is then activated to perform the next dispensing.

As shown in fig. 1B, the movement of the funnel 50 in the second direction is achieved by a movable arm 60, one end of which movable arm 60 is adapted to support the funnel 50, and the other end is slidably connected to a bracket of the racking device 100 by means of a guide rail.

In some embodiments, the one end of the movable arm 60 has a fixed through hole through which at least a portion of the funnel 50 passes such that the funnel 50 is fixedly supported by the one end of the movable arm 60, and an inner wall of the fixed through hole has a slope with respect to a vertical direction, which matches an outer wall slope of the funnel 50, in which case the funnel 50 can be conveniently mounted to the movable arm 60 or dismounted from the movable arm 60, facilitating replacement of the funnel 50, facilitating cleaning or single use of the funnel 50 in direct contact with radioactive particles, and meeting GMP specifications requirements of pharmaceutical production.

If the hopper 50 movable in the second direction is not used, even if the opening of the neck 32 of the hopper 30 at the end portion remote from the receiving portion 31 is aligned with the dispensing container 20, since the opening of the neck 32 of the hopper 30 at the end portion remote from the receiving portion 31 is spaced apart from the dispensing container 20 by a predetermined distance, there is still a risk of leakage of the radioactive particles during dispensing, and a portion of the radioactive particles flowing out from the opening of the neck 32 of the hopper 30 at the end portion remote from the receiving portion 31 may not enter the dispensing container 20 and remain around the dispensing container 20. In order to ensure that the radioactive particles flowing out of the opening of the neck 32 of the hopper 30, which is remote from the end of the receiving portion 31, only enter the dispensing container 20, the hopper 30 may be designed to be movable in the second direction, and the vibrating means 40 may be activated after the end of the neck 32, which is remote from the receiving portion 31, has been inserted into the dispensing container 20, so as to achieve dispensing. However, in this manner, the hopper 30 needs to be moved frequently to pack the radioactive particles into the plurality of packing containers 20, and each packing container needs to perform the movement of the hopper 30, which may cause the unexpected vibration of the hopper 30 during the movement to cause the unexpected release of the particles in the hopper 30, thereby affecting the packing accuracy. The above-described problem may be overcome by using a dispensing device 100 having a funnel 50 that is movable in a second direction in fig. 1B.

Some embodiments of the present disclosure further provide a method for dispensing radioactive particles, using the dispensing apparatus described above, as shown in fig. 3, the method for dispensing radioactive particles includes:

s301: placing the sub-packaging container on the bearing table;

specifically, the sub-packaging container 20 is placed on the loading table 10 using a robot arm, for example.

S303: filling the hopper with the radioactive particles;

specifically, the radioactive particles in the raw material bottles are charged into the hopper 30 using, for example, a robot arm.

S305: and controlling the vibration device to vibrate until the amount of the radioactive particles in the sub-packaging container meets the sub-packaging standard.

Specifically, the vibration device 40 is controlled to vibrate, for example, by controlling the vibration device 40 to perform vibration operation using the vibration parameters in the foregoing embodiments 1 and 2, and at least the weight of the radioactive particles in the dispensing container 20 is approximately equal to the standard dispensing amount, for example, 100mg.

Further, in the prior art, the following technical problems exist with respect to the split charging of radioactive particles:

To at least one of the problems in the related art as described above, to meet the packaging requirement of medical radioactive particles, accurate packaging of the radioactive particles is achieved, and meanwhile, pollution of the radioactive particles in the packaging process can be avoided, some embodiments of the present disclosure provide a packaging device of the radioactive particles, including: a carrying platform configured to hold the sub-packaging containers; a hopper comprising a receiving portion and a neck portion positioned below the receiving portion in communication with the receiving portion, the neck portion configured to receive radioactive particles to be dispensed, an end of the neck portion remote from the receiving portion being provided with an opening configured to be aligned with the dispensing container; the diameter of the accommodating part is larger than that of a raw material bottle body for accommodating the radioactive particles, and the neck part has a sufficient length so that the radioactive particles to be packaged are positioned below the junction of the accommodating part and the neck part after the radioactive particles to be packaged are poured into the neck part, and the radioactive particles can be prevented from flying out of the accommodating part 31 and polluting the box body due to negative pressure in the box body; a screen disposed in the neck configured to receive the radioactive particles to be packaged; and the vibrating device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction, so that the radioactive particles penetrate through the screen and are split-packed into the split-packing containers through the opening of the neck part away from the accommodating part. Wherein, the diameter of the accommodation part 31 is larger than the diameter of the raw material bottle body for accommodating the radioactive particles, so that when the manipulator grabs the raw material bottle and guides the radioactive particles in the raw material bottle into the hopper, the accommodation part 31 has a large enough diameter, thereby providing a large redundant space, avoiding the risk of leakage of the radioactive particles caused by inaccurate alignment of the manipulator to the hopper, and avoiding the risk of negative pressure in the box body sucking the radioactive particles leaking out of the hopper in the future. In addition, the neck portion is provided with a sufficient length, for example, an elongated structure, specifically, for example, the length of the neck portion ranges from 30 cm to 50cm, so that when the radioactive particles to be dispensed are poured into the neck portion, the radioactive particles to be dispensed are definitely located below the junction of the accommodating portion and the neck portion (i.e., all enter the neck portion), and the radioactive particles are not accumulated in the accommodating portion 31, so that the risk of pollution to the box body caused by flying out of the radioactive particles from the accommodating portion 31 due to negative pressure in the box body can be further avoided.

In some embodiments, as shown in fig. 2, the neck is generally tapered, i.e., has a configuration with a greater upper thickness and a lesser lower thickness, so that the upper end of the neck has sufficient space to accommodate the radioactive particles to be dispensed. Further, the radioactive particles can be prevented from flying out of the accommodating portion 31 due to the negative pressure in the case, and the case can be prevented from being polluted.

In some embodiments, as shown in fig. 4, the neck 32 further includes a receiving portion 322, where the receiving portion 322 protrudes smoothly outward along the neck 32, so that the receiving portion 322 has enough space to hold the radioactive particles to be dispensed, and when the radioactive particles enter the neck 32 from the receiving portion 31, the excessive radioactive particles are preferentially accumulated in the receiving portion 322 for storage.

In some embodiments, the accommodating portion 322 is substantially in a conical structure, where an included angle θ between a lower edge of the conical structure and the connection portion of the neck is greater than 120 degrees, so as to ensure that the connection portion between the lower edge of the conical structure and the neck does not cause accumulation of radioactive particles after the vibration sub-packaging is completed, and the radioactive particles can easily fall into the screen 321 under the vibration of the vibration device 40. The screen 321 is arranged near the lower edge of the conical structure and at the joint of the neck, so that the radioactive particles are ensured to be stacked on the accommodating part 322 as much as possible, and the accommodating part 322 has an outwards protruding structure, so that the radioactive particles can be prevented from flying out of the accommodating part 31 due to negative pressure in the box body, and the pollution to the box body is avoided.

In some embodiments, referring to fig. 1B and 5, the racking device 100 further includes a funnel 50, the funnel 50 being disposed below the hopper 30 and configured to be movable in a first direction and/or a second direction, wherein the first direction may be a horizontal direction and the second direction may be a vertical direction, and the funnel 50 may be aligned with the hopper 30 by movement in the first direction. The funnel 50 comprises an inlet 501 from which the end of the neck 32 of the funnel 30 remote from the receptacle 31 is inserted into the funnel 50, and an outlet 502 of the funnel 50 is inserted into the dispensing container 20 in response to movement of the funnel 50 in a second direction away from the funnel 30, and an outlet 502 of the funnel 50 is withdrawn from the dispensing container 20 in response to movement of the funnel 50 in a second direction towards the funnel 30.

In some embodiments, the inlet 501 has a slope 503, and when the vibration device is not activated, the opening 323 of the neck portion away from the accommodating portion abuts against the slope 503, so as to prevent the radioactive particles to be dispensed from leaking from the screen 321, leaking into the funnel 50 along the opening 323, and leaking into the box from the funnel outlet 502.

In some embodiments, the opening 323 of the neck away from the receiving portion is also a beveled structure having the same inclination as the beveled surface 503 of the inlet 501, and when the opening 323 of the neck away from the receiving portion abuts the beveled surface of the inlet 501, the beveled structure of the opening conforms to the beveled surface of the inlet to prevent radioactive particles to be dispensed from leaking down the screen 321, along the opening 323 into the funnel 50, and from the funnel outlet 502 into the housing.

In some embodiments, the neck is provided with a bumper pad 324 at the edge of the opening remote from the ramp structure of the receptacle, which bumper pad conforms to the ramp of the inlet 501. The bumper pad 324 may be such that upon moving the funnel 50 in the first direction or the second direction to the neck opening 323 of the funnel, impact with the neck opening 323 is caused by mechanical force, thereby damaging the funnel or funnel, or further causing leakage of radioactive particles. Wherein the bumper pad 324 is made of a soft rubber, plastic, or the like.

In some embodiments, the screen is disposed on a side of the neck adjacent to the opening such that the neck of the upper portion of the screen has sufficient accommodation space. When the screen is arranged below the neck, and the neck has enough length, the neck on the upper part of the screen has enough accommodating space, so that radioactive particles can be prevented from flying out of the accommodating part 31 due to negative pressure in the box body, and pollution to the box body is avoided.

In some embodiments, the material of the hopper comprises one or a combination of glass, plastic or aluminum, and an aluminum foil layer is arranged on the inner wall of the hopper, so that on one hand, pollution of radioactive particles to the hopper is reduced, and in addition, friction force can be reduced, so that the radioactive particles can leak conveniently.

Some embodiments of the present disclosure provide a method for dispensing radioactive particles, as shown in fig. 6, using the dispensing apparatus according to the foregoing embodiments, the method for dispensing radioactive particles includes the following steps:

step S601: placing the sub-packaging container on the bearing table;

step S603: moving the funnel in a first direction and/or a second direction so that the opening of the neck away from the accommodating part abuts against the inclined surface;

step S605: filling the hopper with the radioactive particles so that the radioactive particles enter the neck and are carried by the screen;

step S607: moving the funnel in a first direction and/or a second direction, separating the opening of the neck away from the accommodating part from the state that the inclined surface abuts against, inserting the end of the neck away from the accommodating part into the funnel from the inlet, and simultaneously inserting the end of the outlet of the funnel into the sub-packaging container;

Step S609: the vibration device is controlled to vibrate so that particles pass through the screen mesh and fall into the split charging container.

According to the embodiment of the disclosure, the diameter of the containing part is larger than that of the raw material bottle body for containing the radioactive particles, so that the radioactive particles are prevented from scattering in the process of pouring the radioactive particles into the containing part from the raw material bottle, meanwhile, the neck part is long enough, so that the radioactive particles to be packaged are positioned below the joint of the containing part and the neck part after the radioactive particles to be packaged are poured into the neck part, and the radioactive particles are further prevented from scattering outside the hopper due to negative pressure in the operation box; the radioactive particles are prevented from scattering out of the hopper due to negative pressure in the operation box by further arranging the accommodating part, arranging the screen on one side of the neck close to the opening and the like. Further, in the prior art, the following technical problems exist with respect to the split charging of radioactive particles:

1. when vibration split charging is not started, the raw material bottle grabbing manipulator turns over, and radioactive particles are poured into the split charging hopper, a small amount of powder is scattered from a screen at the bottom of the hopper to the box body as the screen holes are larger than the particle size of the powder after all;

2. In the process of packaging radioactive particles, when one penicillin bottle is packaged and the next penicillin bottle is not ready, powder is scattered from a screen at the bottom of a hopper to the table surface of the equipment due to unexpected vibration of the environment.

To at least one of the problems in the related art as described above, in order to meet the requirement of packaging of medical radioactive particles, accurate packaging of the radioactive particles is achieved, and meanwhile, pollution of the radioactive particles before and after packaging can be avoided, some embodiments of the present disclosure provide a packaging device for the radioactive particles, and the same structure has the same technical effect, which is not described herein, and see description of the above embodiments, specifically including: a carrying platform configured to hold the sub-packaging containers; a hopper comprising a receiving portion and a neck portion positioned below the receiving portion in communication with the receiving portion, the neck portion configured to receive radioactive particles to be dispensed, an end of the neck portion remote from the receiving portion being provided with an opening configured to be aligned with the dispensing container; a screen disposed in the neck configured to receive the radioactive particles to be packaged; a blocker disposed below the screen of the neck and configured to have an open state and a closed state for blocking missing radioactive particles when the blocker is in the closed state and falling along the neck when the blocker is in the open state; the vibration device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction; wherein, in response to vibrating device stop work, the screen cloth prevents the radioactive particles passes through the neck, and the separation ware is closed in order to separate from the screen cloth is missed the radioactive particles, in response to vibrating device work, the separation ware is opened and the radioactive particles pass the screen cloth, keep away from through the neck the opening of holding portion partial shipment to in the partial shipment container. The opening and closing of the barrier are synchronously controlled by a control signal following the control signal of the vibration device, namely, the barrier is opened before the vibration device starts vibrating, and the barrier is closed after the vibration device finishes vibrating.

In some embodiments, the barrier 325 may include a plurality of rotatable open and closed portions, such as two, three, four, etc., without limitation. A plurality of rotatable opening and closing parts form a sealing whole when being closed, are used for avoiding scattering of missed radioactive particles, and can normally split the radioactive particles when being opened.

In some embodiments, as shown in fig. 7, the barrier 325 comprises a first rotatable barrier 3251 and a second rotatable barrier 3252, the first barrier 3251 and the second barrier 3252 end-sealing abutting when the first barrier 3251 and the second barrier 3252 are rotated to a closed position, the barrier 325 in a closed state; when the first and

second shutters

3251, 3252 are rotated to the open position, the first and

second shutters

3251, 3252 extend downwardly along the neck 32, and the shutters 325 are in the open state. The rotatable first blocking device 3251 and the rotatable second blocking device 3252 are not limited to be controlled by the micro rotating shaft 3254, the rotating teeth (not shown), and the motor (not shown), and will not be described herein.

In some embodiments, as shown in fig. 8-9, the first and

second stoppers

3251 and 3252 are each planar or arcuate, wherein when the first and

second stoppers

3251 and 3252 are each planar, the first and

second stoppers

3251 and 3252, when closed, form a split circle, for example, in the cross section of the neck 32. When the first and

second stoppers

3251, 3252 are each arcuate, the first and

second stoppers

3251, 3252, when closed, form a portion of a split hemisphere or sphere, for example, in the cross section of the neck 32, front and back.

In some embodiments, the first and

second stoppers

3251 and 3252 are cambered, and the radian of the first and

second stoppers

3251 and 3252 is the same as the radian of the neck where they are located, so that when the first and

second stoppers

3251 and 3252 rotate to the open position, the first and

second stoppers

3251 and 3252 are attached to the inner wall of the neck and extend downward, and after the first and

second stoppers

3251 and 3252 are attached to the inner wall of the neck, a falling space of the radioactive particles can be formed to the maximum extent, avoiding attachment to the surface of the stoppers, wherein attachment is not necessarily tight with a tight seam, and there may be a proper gap with the inner wall of the neck, and a larger falling space can still be formed.

In some embodiments, the first and

second blockers

3251, 3252 are asymmetric in structure, and the closed position is located in a non-axial position of the neck when the first and

second blockers

3251, 3252 are rotated to the closed position. When the first blocking device 3251 and the second blocking device 3252 are in an asymmetric structure, once the first blocking device 3251 and the second blocking device 3252 are not completely sealed and butted, the large-area first blocking device 3251 can still receive the missing radioactive particles, and particularly when the first blocking device 3251 and the second blocking device 3252 are in an arc shape, the large-area first blocking device 3251 alone forms a concave receiving part, so that the missing radioactive particles can be effectively received.

In some embodiments, the end of the first and

second barriers

3251, 3252 that are sealingly abutted are each provided with a flexible portion 3253. In some embodiments, the flexible portion comprises any one or combination of a brush, an elastic rubber, a fabric. The flexible portion 3253 can avoid the interference contact or insufficient contact between the first and

second barriers

3251 and 3252 due to thermal expansion and contraction, and avoid damage to the first and second

rigid barriers

3251 and 3252.

In some embodiments, the funnel further comprises a solenoid valve disposed above the outlet, the solenoid valve preventing omission of the radioactive particles when closed. The electromagnetic valve can be uniformly controlled by the controller, when the split charging is started, the electromagnetic valve is opened, and after the split charging is finished, the electromagnetic valve is closed so as to prevent the omission of radioactive particles.

In some embodiments, as shown in fig. 10, the dispensing device further comprises: a waste tray 70 is placed on the carrying table for holding the sub-packaging containers and receiving the missing radioactive particles. In some embodiments, the waste tray includes a recess 71 for receiving the dispensing container. In the granule split charging process, when radioactive powder is scattered from the bottom of the hopper due to unexpected vibration of the environment in a state that no penicillin bottle is arranged under the split charging hopper, the radioactive powder can be received by the waste tray 70. The waste tray 70 is a disposable replaceable device or a reusable device.

Some embodiments of the present disclosure provide a method for packaging radioactive particles, using the packaging apparatus according to any of the embodiments described above, the method comprising the following steps:

Step S1101: placing a waste tray on the carrying table;

step S1103: placing the sub-packaging container in a groove of the waste tray;

step S1105: moving the funnel in a first direction and/or a second direction, enabling the neck to be far away from the opening of the containing part and to be inserted into the funnel from the funnel inlet, and enabling the end part where the outlet of the funnel is positioned to be inserted into the sub-packaging container;

step S1107: opening the barrier to rotate the barrier from a closed state to an open state;

step S1109: and controlling the vibration device to vibrate until the amount of the radioactive particles in the sub-packaging container meets the sub-packaging standard.

The radioactive particle split charging device provided by the embodiment of the disclosure avoids omission of radioactive particles after split charging is completed by additionally arranging the baffle, specifically, the baffle is arranged below a screen mesh at the neck of the hopper and is controlled to be in an opening state and a closing state, the operation of the vibration device is stopped, the screen mesh prevents the radioactive particles from passing through the neck, the baffle is closed to separate the radioactive particles omitted from the screen mesh, the vibration device is operated, the baffle is opened and the radioactive particles pass through the screen mesh, and the radioactive particles are split charged into the split charging container through the opening of the neck away from the accommodating part. In addition, through the technical means such as setting up the waste tray, setting up solenoid valve in the funnel, further avoided the partial shipment to finish the omission of back radioactive particle.

1. in the vibration sub-packaging process, in the state that particles are still in the hopper, the particles cannot be released due to the failure of the vibrator;

2. after vibration sub-packaging is finished, radioactive particles can be left in the sub-packaging paths of the hopper, and in the transportation process of sub-packaging equipment, the reflective particles can leak due to vibration, so that pollution is caused to the box body.

To at least one of the problems in the related art as described above, to meet the packaging requirement of medical radioactive particles, accurate packaging of the radioactive particles is achieved, and meanwhile, pollution of the radioactive particles after packaging can be avoided, and some embodiments of the present disclosure provide a self-cleaning packaging device of the radioactive particles, including: a carrying platform configured to hold the sub-packaging containers; a hopper comprising a receiving portion and a neck portion positioned below the receiving portion in communication with the receiving portion, the neck portion configured to receive radioactive particles to be dispensed, an end of the neck portion remote from the receiving portion being provided with an opening configured to be aligned with the dispensing container; a screen disposed in the neck configured to receive the radioactive particles to be packaged; the main vibration device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction; the auxiliary vibrating device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction; wherein in response to vibratory operation of the primary vibratory device and/or the secondary vibratory device, the radioactive particles pass through the screen and are dispensed into the dispensing container through the neck opening away from the receptacle; in response to the primary and secondary vibrating devices being deactivated, the screen prevents the radioactive particles from passing through the neck.

In some embodiments, as shown in fig. 12, the dispensing device further comprises: the control device is configured to control the main vibration device and the auxiliary vibration device to simultaneously execute vibration so as to drive the hopper and the screen to vibrate in a first direction; at this time, the control device distributes balanced driving current to the vibrating device and the auxiliary vibrating device so that the vibrating device and the auxiliary vibrating device vibrate in a coordinated and consistent mode with the same frequency and the same amplitude.

In some embodiments, the control device may be further configured to control the main vibration device to perform a vibration operation first, and when the main vibration device drives the hopper and the screen to vibrate in a first direction, the auxiliary vibration device follows the main vibration device to vibrate; when the main vibrating device fails, the auxiliary vibrating device is controlled to drive the hopper and the screen to vibrate in a first direction, and the main vibrating device follows the auxiliary vibrating device to vibrate. The vibrating device adopts redundant design, and when main vibrating device became invalid, steerable auxiliary vibrating device drive hopper continued partial shipment, avoided single vibrating device to become invalid after, still left over radioactive particles in the partial shipment equipment such as hopper, on the one hand caused the radioactive particles extravagant, on the other hand also prevented that these left over radioactive particles from leaking in the middle of the later stage vibration in the box, caused the pollution of box. Wherein, the following refers to passive movement, i.e. the control device does not provide active driving force to make the control device vibrate, and does not provide active back driving force to prevent the control device from vibrating, but does not provide any driving external force to the following driving device, so that the control device only vibrates by virtue of the vibration of the vibrating device with the driving external force.

In some embodiments, as shown in fig. 12, the sub-packaging device further includes an alarm device, configured to send an alarm signal to the control device when the main vibration device fails, where the control device controls the auxiliary vibration device to drive the hopper and the screen to vibrate in a first direction according to the alarm signal, and controls the main vibration device to vibrate following the auxiliary vibration device.

In some embodiments, the carrier includes a weight sensor that weighs the racking container in real time to obtain the weight of the radioactive particles loaded into the racking container. The primary and/or secondary vibrating means, when performing a vibratory racking operation, vibrates at a first vibration frequency that decreases as the weight of the radioactive particles loaded into the racking container increases. The control of the vibration frequency in the normal split charging process of the main vibration device and the auxiliary vibration device and the technical effects thereof are as described in the foregoing embodiments, and are not described in detail herein.

In some embodiments, the first vibration frequency F of the primary and/or secondary vibration means satisfies the following formula:

In some embodiments, the primary and/or secondary vibration device vibrates at a second vibration frequency when the dispensing operation is stopped, the second vibration frequency ranging from 180-300Hz. The applicant found that under the above normal frequency vibration, the vibration device can ensure accurate split charging of the radioactive particles, but after the split charging is finished, a small amount of radioactive particles still remain on the side wall of the neck of the hopper, the accommodating portion 322, the screen 321, and even the opening 323 far away from the accommodating portion, and after the split charging is finished, the residual radioactive particles can be missed into the box body in the later transportation process, so that the pollution of the box body is caused. For this reason, it is necessary to temporarily increase the vibration frequency when the main and/or auxiliary vibration means stops the dispensing operation, so as to shake out the residual radioactive particles to the waste tray, to avoid the occurrence of contamination of the bin. The applicant has found that, by experiment, the frequency of the increase is preferably about 3 times the previous vibration frequency, for example, the vibration frequency is in the range of 180-300Hz.

In some embodiments, the primary and/or secondary vibration means, when performing a vibratory racking operation, vibrates at a first amplitude that decreases as the weight of the radioactive particles loaded into the racking container increases. The control of the vibration amplitude and the technical effects thereof in the normal sub-packaging process of the main vibration device and the auxiliary vibration device are as described in the foregoing embodiments, and are not described in detail herein.

In some embodiments, the first amplitude a of the primary and/or secondary vibration means satisfies the following formula:

In some embodiments, the primary and/or secondary vibration means vibrate at a second amplitude when the dispensing operation is stopped, the second amplitude being in the range of 1000-1500 μm. As described above, the applicant has found that under the above normal vibration of the vibration amplitude, the vibration device can ensure accurate dispensing of the radioactive particles, but after the dispensing is completed, a small amount of radioactive particles still remain on the side wall of the neck of the hopper, the accommodating portion 322, the screen 321, and even the opening 323 far away from the accommodating portion, and after the dispensing is completed, the residual radioactive particles are missed into the box during the later transportation process, so as to pollute the box. For this reason, it is necessary to temporarily increase the vibration amplitude when the main and/or auxiliary vibrating means stops the dispensing operation, so as to shake out the residual radioactive particles to the waste tray, to avoid the occurrence of contamination of the bin. The applicant has found that, by experiment, the amplitude of the increase is preferably about 3 times the previous vibration frequency, for example, the vibration range of the amplitude is 1000-1500 μm.

In some embodiments, the dispensing device further comprises a waste tray 70 disposed on the carrying platform, and when dispensing is completed, the waste tray 70 receives radioactive particles scattered by secondary vibration of the main and auxiliary vibration devices, so as to avoid pollution caused by scattering to other devices of the box body.

Some embodiments of the present disclosure provide a self-cleaning packaging method for radioactive particles, using the packaging device according to any of the embodiments described above, the packaging method including the steps of:

step S1301: placing the sub-packaging containers on the bearing table;

step S1303: moving the funnel in a first direction and/or a second direction, enabling the neck to be far away from the opening of the containing part and to be inserted into the funnel from the funnel inlet, and enabling the end part where the outlet of the funnel is positioned to be inserted into the sub-packaging container;

step S1305: and controlling the main vibration device and/or the auxiliary vibration device to perform vibration work at a first frequency and/or a first amplitude until the amount of the radioactive particles in the sub-packaging container meets a sub-packaging standard.

In some embodiments, further comprising:

step S1307: and when the main vibration device and/or the auxiliary vibration device stop the sub-packaging work, controlling the main vibration device and/or the auxiliary vibration device to execute the vibration work at the second frequency and/or the second amplitude.

According to the radioactive particle self-cleaning and split charging device provided by the embodiment of the disclosure, the main vibration device and the auxiliary vibration device are arranged, so that the main vibration device and the auxiliary vibration device simultaneously execute vibration work, and the driving power of each vibration device is reduced; or firstly controlling the main vibration device to execute vibration work, and enabling the auxiliary vibration device to vibrate along with the main vibration device; when the main vibration device fails, the auxiliary vibration device is controlled to drive the hopper and the screen to vibrate in a first direction, and the main vibration device follows the auxiliary vibration device to vibrate; so as to avoid the risk of stopping the split charging work and discharging radioactive particles caused by the failure of one vibrating device; in addition, when the split charging work is finished, the vibration frequency or the vibration amplitude of the main vibration device and/or the auxiliary vibration device is increased, so that self-cleaning of the split charging hopper and the like is realized, and the leakage of radioactive particles is further avoided.

in the split charging process, the split charging hopper needs to be lowered below the opening of the split charging container and above the liquid level in the split charging container, but the hopper is lowered too low to enter below the liquid level due to the fact that the lowering height of the hopper cannot be accurately controlled, and split charging cannot be carried out. Or the funnel is not enough in descending height, so that the funnel opening is above the opening of the split charging container, and particles are scattered outside the split charging container in the split charging process, so that the pollution of the box body is caused.

To at least one of the problems among the related art as described above, for satisfying the partial shipment demand of medical radioactive particle, realize the accurate partial shipment to radioactive particle, can avoid the pollution of radioactive particle among the partial shipment process simultaneously, some embodiments of this disclosure provide a partial shipment equipment with liquid level positioning function, be applied to radioactive particle partial shipment, include: a carrying table configured to place a dispensing container, wherein the dispensing container is preloaded with a dispensing liquid, and the liquid level of the dispensing liquid is a first preset distance H1 from the container opening of the dispensing container, as shown in fig. 14; a hopper comprising a receiving portion and a neck portion positioned below the receiving portion in communication with the receiving portion, the neck portion configured to receive radioactive particles to be dispensed, an end of the neck portion remote from the receiving portion being provided with an opening configured to be aligned with the dispensing container; a funnel disposed below the hopper and configured to be movable in a first direction and/or a second direction, the funnel including an inlet 501, a drain handle 504, and an outlet 502, an end of the neck distal from the receiving portion being inserted into the funnel from the inlet and an end of the funnel at which the outlet is inserted into the dispensing container in response to movement of the funnel in the first direction and/or the second direction; the position sensor 505 is disposed at an end portion where the outlet of the funnel is located, and configured to detect a depth of the end face where the outlet of the funnel is located inserted into the sub-packaging container, so that the end face where the outlet of the funnel is located at a second preset distance H2 from the liquid surface.

As a specific example, the packaging container is usually a penicillin bottle, the height of the penicillin bottle is about 3-5cm, the diameter of the penicillin bottle is about 0.8-1.5cm, the packaging liquid level is usually 1-4.5cm before packaging, and the distance between the end surface of the outlet of the funnel and the liquid level is usually 0.3-1.8cm. The above data is not particularly limited, and is determined by parameters of the actual dispensing container.

In some embodiments, the ratio of the second preset distance H2 to the first preset distance H1 is 30% -60%. The applicant finds that when the ratio of the second preset distance H2 to the first preset distance H1 is 30% -60%, the radioactive particles falling from the split charging hopper in the split charging process can be prevented from splashing liquid or colloid of powder and liquid after falling into the liquid level, so that the outlet of the hopper is prevented from being blocked; and the pollution of the box body caused by the fact that particles are scattered outside the split charging container in the split charging process because the funnel opening is too close to the split charging container opening is avoided. When the ratio of the second preset distance to the first preset distance is more than 60%, the risk of radioactive particle overflow occurs due to the problem of vibration or negative pressure in the box body, and when the ratio of the second preset distance to the first preset distance is less than 30%, the liquid can be splashed up at the moment of entering the liquid when the weight of the radioactive particles is large enough, so that the pollution of a funnel opening is caused; when the weight of the radioactive particles is not large enough, the particles will form a pile between the funnel opening and the liquid surface in a short time due to the tension of the liquid surface, and the pollution of the funnel opening is caused.

In some embodiments, the second predetermined distance H2 is proportional to the individual weight of the radioactive particles to be dispensed. The larger the weight, the more liquid splashed when falling into the liquid surface, the larger the liquid splashed height, and the weight of the radioactive particles is usually 20-500mg, so that different funnel opening-to-liquid surface distances can be preset for sub-packaging radioactive particles with different weights.

In some embodiments, the carrier includes a weight sensor that weighs the racking container in real time to obtain the weight of the radioactive particles loaded into the racking container. The depth of the end face of the outlet of the funnel inserted into the sub-packaging container is reduced along with the increase of the weight of the radioactive particles filled into the sub-packaging container, so that the end face of the outlet of the funnel keeps the second preset distance H2 from the liquid level. When the radioactive particles are continuously dispensed into the dispensing liquid, this will result in an increase in the dispensing liquid level, and in order not to cause the above-mentioned problems, the second predetermined distance H2 must be maintained, and therefore the funnel can be controlled by the stepper motor to move upwards so that the end face of the outlet of the funnel is maintained at the second predetermined distance H2 from the liquid level.

In some embodiments, the dispensing apparatus further comprises a limiting mechanism configured such that the maximum distance of the end face of the outlet of the funnel from the container mouth of the dispensing container is the first preset distance H1, i.e. to ensure that the funnel will not be inserted below the dispensing level, otherwise dispensing will not be possible due to air pressure. The limiting mechanism is controlled by the stepping motor, after the type of radioactive particles to be packaged is determined, the packaging container and the liquid capacity pre-packaged in the packaging container are determined, so that the control device can set the maximum descending depth for the funnel in the initial control, and once the maximum descending depth is reached, the limiting mechanism stops driving the stepping motor to prevent the funnel from being inserted below the packaging liquid level. The activation of the limit mechanism is typically caused by inaccuracy in the measured distance due to a position sensor malfunction.

In some embodiments, the position sensor 505 comprises one of a laser sensor, an ultrasonic sensor, an image sensor, or a combination thereof. The position sensor is arranged at a certain position above the funnel outlet in advance, for example, the position sensor is arranged at a certain position 2-3cm above the funnel outlet in advance, so that the sensor cannot enter the split charging container or be clamped at the opening of the split charging container. The laser sensor measures the liquid level by measuring the reflection of the liquid level to the optical signal, and the ultrasonic sensor measures the liquid level by emitting liquid level sound waves.

In some embodiments, the racking device further comprises: a screen disposed in the neck configured to receive the radioactive particles to be packaged; the vibrating device is connected with the hopper and is configured to drive the hopper and the screen to vibrate at a preset frequency and/or a preset amplitude in a first direction, and the radioactive particles penetrate through the screen and are split-packed into the split-packed containers through the opening of the neck part far away from the accommodating part in response to the vibration operation of the vibrating device; in response to the vibration device being deactivated, the screen prevents the radioactive particles from passing through the neck; wherein the second preset distance increases with an increase in the preset frequency and/or preset amplitude. When the vibration frequency or amplitude of the vibration device increases, the dropping speed of the radioactive particles to be dispensed is increased, that is, the dispensing speed is increased, and at this time, the distance from the funnel opening to the liquid surface needs to be increased to prevent the funnel opening from being polluted due to splashing of the liquid surface or accumulation of the radioactive particles.

Some embodiments of the present disclosure provide a packaging method with a liquid level positioning function, using the packaging apparatus according to any one of the embodiments described above, as shown in fig. 15, where the packaging method includes the following method steps:

Step S1501: placing a split charging container filled with split charging liquid on the bearing table;

step S1503: moving the funnel in a first direction and/or a second direction, enabling the neck to be far away from the opening of the accommodating part and to be inserted into the funnel from the funnel inlet, and enabling the end part where the outlet of the funnel is positioned to be inserted into the sub-packaging container;

step S1505: controlling the depth of the end face of the outlet of the funnel inserted into the sub-packaging container, so that the end face of the outlet of the funnel is a second preset distance away from the liquid level;

step S1507: and controlling the vibration device to perform vibration work at a preset frequency and/or a preset amplitude until the amount of the radioactive particles in the sub-packaging container meets the sub-packaging standard.

In some embodiments, the controlling the vibration device to perform the vibration operation at a preset frequency and/or a preset amplitude further comprises: and adjusting the depth of the end face of the outlet of the funnel inserted into the sub-packaging container in real time, so that the end face of the outlet of the funnel is kept at a second preset distance from the liquid level.

In some embodiments, the controlling the vibration device to perform the vibration operation at a preset frequency and/or a preset amplitude further comprises: the depth of the end face of the outlet of the funnel inserted into the sub-packaging container is adjusted in real time, so that the second preset distance is increased along with the increase of the preset frequency and/or the preset amplitude, and the second preset distance is reduced along with the decrease of the preset frequency and/or the preset amplitude.

According to the split charging equipment with the liquid level positioning function, the position sensor is arranged, so that the end face of the outlet of the detection funnel is inserted into the depth in the split charging container, the end face of the outlet of the funnel is located at the second preset distance from the liquid level, the second preset distance is adjusted according to the vibration frequency and/or the vibration amplitude of the vibration device, the end face of the outlet of the funnel is located at the second preset distance from the liquid level, and the distance between the end face of the funnel and the liquid level is just right, so that radioactive particles are prevented from falling into the split charging liquid and splashing substances or blocking the outlet of the funnel after falling into the split charging liquid due to too close distance between the end face of the funnel and the liquid level, and the radioactive particles are prevented from falling out of the split charging container from the container opening due to too close distance between the radioactive particles and the container opening, so that the pollution of the box body is caused.

The flowcharts and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present disclosure. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.

Finally, it should be noted that: in the present specification, each embodiment is described in a progressive manner, and each embodiment is mainly described in a different point from other embodiments, and identical and similar parts between the embodiments are all enough to refer to each other. The system or the device disclosed in the embodiments are relatively simple in description, and the relevant points refer to the description of the method section because the system or the device corresponds to the method disclosed in the embodiments.

The above embodiments are merely for illustrating the technical solution of the present disclosure, and are not limiting thereof; although the present disclosure has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present disclosure.

Claims

1. An anti-contamination dispensing device for radioactive particles, comprising:

a carrier configured to hold a sub-packaging container, the carrier comprising a weight sensor that weighs the sub-packaging container in real time to obtain a weight of the radioactive particles loaded into the sub-packaging container;

the main vibration device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction;

the auxiliary vibrating device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction;

the first vibration frequency of the main vibration device and/or the auxiliary vibration device satisfies the following formula:

wherein (1)>

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A standard weight of the radioactive particles planned to be loaded in the sub-packaging container is the weight of the radioactive particles loaded in the sub-packaging container measured by the weight sensor;

Wherein, in response to the main vibrating device and the auxiliary vibrating device stop working, the screen prevents the radioactive particles from passing through the neck, and the barrier is closed to block the radioactive particles missing from the screen, in response to the main vibrating device and/or the auxiliary vibrating device working, the barrier is opened and the radioactive particles pass through the screen, and are split-packed into the split-packed container through the opening of the neck away from the accommodating part.

2. The anti-contamination dispensing apparatus for radioactive particles of claim 1, wherein the barrier comprises a first rotatable barrier and a second rotatable barrier, the first barrier and the second barrier end portions sealingly interfacing when the first barrier and the second barrier are rotated to a closed position, the barrier being in a closed state; when the first and second shutters are rotated to an open position, the first and second shutters extend downwardly along the neck, the shutters being in an open state.

3. The apparatus of claim 2, wherein the first and second barriers are planar or arcuate.

4. The device of claim 3, wherein the first and second stoppers are arcuate and have the same arc as the neck so that when the first and second stoppers are rotated to the open position, the first and second stoppers engage the inner wall of the neck and extend downwardly.

5. The anti-contamination dispensing device of claim 4, wherein the first and second stoppers are asymmetric in structure, the closed position being located at a non-axial position of the neck when the first and second stoppers are rotated to the closed position.

6. An anti-contamination dispensing device for radioactive particles according to any one of claims 2 to 5, wherein the end portions of the first barrier and the second barrier which are sealingly engaged are each provided with a flexible portion.

7. The anti-contamination dispensing device of claim 6, wherein the flexible portion comprises any one or a combination of a brush, an elastic rubber, and a fabric.

8. The anti-contamination dispensing apparatus for radioactive particles according to claim 1, further comprising:

9. The anti-contamination dispensing apparatus for radioactive particles of claim 8, wherein the funnel further comprises a solenoid valve disposed above the outlet, the solenoid valve preventing omission of the radioactive particles when closed.

10. The anti-contamination dispensing apparatus for radioactive particles according to claim 1, further comprising:

11. The apparatus of claim 10, wherein the tray includes a recess for receiving the dispensing container.

12. The anti-pollution dispensing apparatus for radioactive particles of claim 1, wherein the hopper comprises one or a combination of glass, plastic or aluminum, and wherein the inner wall of the hopper is provided with an aluminum foil layer.

13. An anti-pollution packaging method of radioactive particles, which adopts the anti-pollution packaging device of radioactive particles according to claim 8, characterized in that the anti-pollution packaging method of radioactive particles comprises the following steps:

placing a waste tray on the carrying table;

placing the sub-packaging container in a groove of the waste tray;

opening the barrier to rotate the barrier from a closed state to an open state;

and controlling the main vibration device and/or the auxiliary vibration device to vibrate until the amount of the radioactive particles in the sub-packaging container meets the sub-packaging standard.

14. Use of a radioactive particle contamination prevention dispensing apparatus for dispensing a radiopharmaceutical, the apparatus comprising a radioactive particle contamination prevention dispensing apparatus according to any one of claims 1 to 12.