CN115043816B - Chiral resolution method of selenium octanoic acid - Google Patents
Chiral resolution method of selenium octanoic acid Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 30
- NJOYQMJRKZHFFW-UHFFFAOYSA-N [Se].C(CCCCCCC)(=O)O Chemical compound [Se].C(CCCCCCC)(=O)O NJOYQMJRKZHFFW-UHFFFAOYSA-N 0.000 title claims abstract description 10
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 46
- 239000011669 selenium Substances 0.000 claims abstract description 46
- 239000002904 solvent Substances 0.000 claims abstract description 26
- 150000003839 salts Chemical class 0.000 claims abstract description 24
- RIWRFSMVIUAEBX-UHFFFAOYSA-N n-methyl-1-phenylmethanamine Chemical compound CNCC1=CC=CC=C1 RIWRFSMVIUAEBX-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000006243 chemical reaction Methods 0.000 claims abstract description 12
- 238000010438 heat treatment Methods 0.000 claims abstract description 12
- 239000012044 organic layer Substances 0.000 claims abstract description 9
- 238000005406 washing Methods 0.000 claims abstract description 9
- 230000020477 pH reduction Effects 0.000 claims abstract description 5
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 79
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 36
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000002253 acid Substances 0.000 claims description 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 239000012046 mixed solvent Substances 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 12
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 11
- 239000003960 organic solvent Substances 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- 239000003513 alkali Substances 0.000 claims description 6
- 239000012670 alkaline solution Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 239000010410 layer Substances 0.000 claims description 6
- 239000003929 acidic solution Substances 0.000 claims description 5
- 239000012452 mother liquor Substances 0.000 claims description 5
- 238000000967 suction filtration Methods 0.000 claims description 5
- 125000003944 tolyl group Chemical group 0.000 claims description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- 235000015165 citric acid Nutrition 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 235000006408 oxalic acid Nutrition 0.000 claims description 4
- 230000001376 precipitating effect Effects 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 235000011054 acetic acid Nutrition 0.000 claims description 2
- 235000011167 hydrochloric acid Nutrition 0.000 claims description 2
- 239000000047 product Substances 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims 1
- CRDYSYOERSZTHZ-UHFFFAOYSA-M selenocyanate Chemical compound [Se-]C#N CRDYSYOERSZTHZ-UHFFFAOYSA-M 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 238000001953 recrystallisation Methods 0.000 abstract description 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 2
- 239000002244 precipitate Substances 0.000 abstract description 2
- 239000010413 mother solution Substances 0.000 abstract 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 8
- 238000001228 spectrum Methods 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 238000010606 normalization Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 150000002391 heterocyclic compounds Chemical class 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 2
- 235000019136 lipoic acid Nutrition 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 229940065287 selenium compound Drugs 0.000 description 2
- 150000003343 selenium compounds Chemical class 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 229960002663 thioctic acid Drugs 0.000 description 2
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- DYEFUKCXAQOFHX-UHFFFAOYSA-N Ebselen Chemical compound [se]1C2=CC=CC=C2C(=O)N1C1=CC=CC=C1 DYEFUKCXAQOFHX-UHFFFAOYSA-N 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229950010033 ebselen Drugs 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000013332 literature search Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002898 organic sulfur compounds Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 125000003748 selenium group Chemical group *[Se]* 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000032895 transmembrane transport Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D345/00—Heterocyclic compounds containing rings having selenium or tellurium atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses a chiral resolution method of selenium octanoic acid, which uses chiral methylbenzylamine as a resolution reagent and precipitates and separates out corresponding enantiomer salt through salification. After recrystallization, the corresponding single chiral selenocyanate is obtained through acidification reaction. The invention prepares chiral selenocyanate from racemic selenocyanate, has mild reaction conditions, simple process and convenient operation, and is suitable for industrial application; the prepared single chiral selenium octoate has important pharmaceutical application. The invention also provides a method for preparing the racemic selenium octoate by acidifying and washing the mother solution containing the selenium octoate of the other enantiomer in the splitting process, taking out the organic layer, heating the organic layer for reaction under normal pressure, concentrating the solvent and recrystallizing the organic layer to obtain the racemic selenium octoate, thereby fully utilizing the raw materials and reducing the production cost.
Description
Technical Field
The invention belongs to the technical field of organic synthesis, and particularly relates to a chiral resolution method of selenium octoate.
Background
The organic sulfur and selenium compounds have various biological activities such as anti-tumor, antioxidation, antifungal and the like. In recent years, scientists have conducted a great deal of research on the synthesis and biological activity of organic selenium compounds, and particularly on selenium-containing five-membered heterocyclic compounds, and attention has been paid to the research on the use of ebselen, selenazolofuran, and the like as representative drugs for clinical trials (see Rafique J, canto RFS, saba S, et al Current Organic Chemistry,2016,20 (2): 166-188.). The literature reports that five-membered heterocyclic compounds containing diselenide bonds have higher ring tension, stronger acidity and acidity of reducing alcohol than disulfide bond compounds, are easier to be taken in by cells, have better intracellular stability, have the advantages of high bioavailability, strong biological activity and the like, wherein the selenium octoate performs best (see Chuard N, poblader-Bahande AI, zong LL, et al chemical Science,2018,9 (7): 1860-1866.). Selenium octoate itself has the advantages of small molecular volume, convenient synthesis, high stability, good solubility, low toxicity and the like, and further research finds that the selenium octoate has very efficient and strong transmembrane transport capacity and can even carry substrates with two orders of magnitude larger volumes than the selenium octoate itself into cells (see Bartolami E, basagitanis D, zong L, et al chemistry-A European Journal,2019, 25:4047-4051.).
Selenium octanoic acid is a bioisostere of lipoic acid, and is a compound obtained by replacing sulfur atoms at 6 and 8 positions with selenium atoms based on the structure of lipoic acid. The molecular structure of the selenium octoate contains a chiral center, and the method for obtaining the single chiral selenium octoate is a key material basis from the aspects of pharmaceutical application development and pharmacological research, and is necessary to establish a method for simply, conveniently and efficiently obtaining the chiral selenium octoate. Through literature search, no report of effective resolution of selenium octanoic acid is found, and related patent disclosure is not found.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the chiral resolution method of the selenium octanoic acid, which has the advantages of mild reaction conditions, simple process, convenient operation and suitability for industrial application.
The technical scheme adopted by the invention is as follows: a chiral resolution method of selenium octanoic acid comprises the following specific steps:
step one: heating selenium Xin Suanrong in a first solvent to 25-80 ℃, dropwise adding chiral methylbenzylamine, wherein the molar ratio of selenium octoic acid to the chiral methylbenzylamine is 1:0.5-0.8, the chiral methylbenzylamine is R-methylbenzylamine or S-methylbenzylamine, separating out tan solid, cooling, and suction filtering to obtain the salt of R-selenium octoic acid and chiral methylbenzylamine or the salt of S-selenium octoic acid and chiral methylbenzylamine;
step two: recrystallizing the salt with a second solvent for 1 to 5 times, and purifying;
step three: dissolving the obtained salt in an organic solvent, heating to 25-80 ℃, dropwise adding an acidic solution, stirring for 0.5-1 hour, adding water, extracting, taking an organic solvent layer, washing with water, drying with anhydrous magnesium sulfate, and spin-drying to obtain R-selenium octanoic acid or S-selenium octanoic acid;
or dissolving the obtained salt in alkaline solution, washing with organic solvent, dripping acidic solution to adjust pH to 1-2, precipitating a large amount of tan solid, suction filtering, and drying to obtain R-selenium octanoic acid or S-selenium octanoic acid.
In the first step, the first solvent is formed by mixing any one or two of acetonitrile, toluene, tetrahydrofuran and water according to any proportion, and the volume/mass ratio of the solvent to the selenium octoic acid is 5-10 ml/g.
In the second step, the second solvent is toluene, acetonitrile or acetone, or a toluene/methanol mixed solvent, a toluene/ethanol mixed solvent, a toluene/isopropanol mixed solvent, a toluene/water mixed solvent, an acetonitrile/methanol mixed solvent, an acetonitrile/ethanol mixed solvent, an acetonitrile/isopropanol mixed solvent, or an acetonitrile/water mixed solvent; in the mixed solvent, the front-to-back volume ratio of "/" is 1:0.2-5.
Further, in the third step, the organic solvent is toluene, dichloromethane, chloroform or ethyl acetate; the volume-mass ratio of the organic solvent to the obtained salt is 5-10 ml/g.
Further, in the third step, the acid of the acid solution is hydrochloric acid, acetic acid, citric acid, oxalic acid or tartaric acid, and the molar ratio of the obtained salt to the acid is 1:1-1.2; the solvent of the acid solution is water, methanol or ethanol, and the volume-mass ratio of the solvent to the acid is 1-5 ml/g.
Further, in the third step, the alkali of the alkaline solution is sodium hydroxide or potassium hydroxide, and the molar ratio of the obtained salt to the alkali is 1:1-1.2; the solvent of the alkaline solution is water, methanol or ethanol, and the volume-mass ratio of the solvent to the alkali is 1-5 ml/g.
Further, in the first step, the mother liquor after suction filtration is used for recovering the selenium octanoic acid by the following method: acidifying the filtrate, washing with water, and collecting the organic layer; and then heating the organic layer for reaction under normal pressure, concentrating the solvent, and recrystallizing to obtain the selenium octoic acid.
Further, the acidulation is to adjust the pH of the filtrate to 1-3 with an acid selected from hydrochloric acid, acetic acid, sulfuric acid, citric acid, oxalic acid, tartaric acid.
Further, the heating reaction temperature is 60 to 120 ℃, and the heating reaction time is 6 to 24 hours.
Further, the product after concentrating the solvent was recrystallized from cyclohexane.
The beneficial effects of the invention are as follows:
1. the invention uses chiral methylbenzylamine as a resolution reagent, and precipitates and separates out corresponding enantiomer salts through salification. After recrystallization, the corresponding single chiral selenocyanate is obtained through acidification reaction. The invention prepares chiral selenocyanate from racemic selenocyanate, has mild reaction conditions, simple process and convenient operation, and is suitable for industrial application; the prepared single chiral selenium octoate has important pharmaceutical application.
2. The organic layer is taken out after acidification and water washing of the selenium octoate mother liquor containing the other enantiomer in the splitting process, the organic layer is heated and reacted under normal pressure, and the racemic selenium octoate is obtained after concentration of the solvent and recrystallization, so that the raw materials are fully utilized, and the production cost is reduced.
Detailed Description
The corresponding reaction of the invention is as follows:
the invention will be further illustrated with reference to specific examples.
EXAMPLE 1 preparation of R-selenooctanoic acid
Selenium octoic acid (39.0 g, 0.13 mol) was dissolved in toluene (270 ml), heated to 40 ℃, R-methylbenzylamine (10.1 g, 0.083 mol) was added dropwise, a large amount of tan solid was precipitated, cooled, suction filtered, and 24.3 g of R-selenium octoic acid-R-methylbenzylamine salt was obtained. Repeatedly recrystallizing the salt with a mixed solution of toluene and methanol for 5 times, sequentially reducing the dosage of toluene and properly increasing the dosage of methanol, and finally obtaining 20.9 g of salt. The obtained salt was dissolved in toluene (100 ml), heated to 35 ℃, a solution of citric acid (9.6 g, 0.05 mol) in methanol (20 ml) was added dropwise, stirred for 1 hour, water (60 ml) was added, extraction was performed, a toluene layer was taken, and washed three times with water (10 ml), dried over anhydrous magnesium sulfate, and dried by spinning to obtain R-selenooctanoic acid: tan solid, 13.3 g, overall yield: 68.2% (calculated as 19.5g of theoretical R-selenium octoate); purity: 96.2% (liquid phase area normalization method); melting point mp:81.2-82.8 ℃; optically active substanceInfrared IR v max (KBr)/cm -1 :3025,1701,1427,1245,1204,942,731; hydrogen spectrum 1 H NMR(600MHz,CDCl 3 ),δ：3.91(m,1H,Se-CH-),3.32(t,2H,J＝6.0Hz,Se-C 2 H-),3.00-2.95(m,1H,Se-CH 2 -CHH-),2.52(m,1H,Se-CH 2 -CHH-),2.38(t,2H,J＝7.2Hz,C 2 H-CO-),1.87-1.81(m,1H,CHH-CH 2 -CH 2 -CH 2 -CO-),1.78-1.72(m,1H,CHH-CH 2 -CH 2 -CH 2 -CO-),1.73-1.63(m,2H,C 2 H-CH 2 -CO-),1.53-1.43(m,2H,-C 2 H-CH 2 -CH 2 -CO-); carbon spectrum 13 C NMR(150MHz,CDCl 3 ) And delta: 179.1,52.5,45.7,35.3,33.7,29.6,29.4,24.4; mass spectrometry ESI-MS:300.9 ([ M-H)] - )。
EXAMPLE 2 preparation of R-selenooctanoic acid
Selenium octoic acid (39.0 g, 0.13 mol) was dissolved in toluene (270 ml), heated to 40 ℃, R-methylbenzylamine (10.1 g, 0.083 mol) was added dropwise, a large amount of tan solid was precipitated, cooled, suction filtered, and 24.3 g of R-selenium octoic acid-R-methylbenzylamine salt was obtained. Adding a small amount of acetone into the salt, heating to 50 ℃ for dissolution, gradually cooling to 0 ℃, precipitating a large amount of solid, carrying out suction filtration, and repeating the above operation for 1 time on the filter cake. Dissolving the obtained solid in sodium hydroxide solution, washing with dichloromethane, regulating the pH to 1-2 with dilute hydrochloric acid, precipitating a large amount of tan solid, filtering, and vacuum drying to obtain R-selenium octanoic acid: tan solid, 6.1 g, overall yield: 31.2% (calculated as 19.5g of theoretical R-selenooctanoic acid); purity: 97.9% (liquid phase area normalization method).
EXAMPLE 3 preparation of S-selenium octanoic acid
Selenium octoic acid (39.0 g, 0.13 mol) was dissolved in toluene (270 ml), heated to 40 ℃, S-methylbenzylamine (10.1 g, 0.083 mol) was added dropwise, a large amount of tan solid was precipitated, cooled, suction filtered, and 23.3 g of S-selenium octoic acid-S-methylbenzylamine salt was obtained. The salt was repeatedly recrystallized 3 times from a mixed solution of toluene and methanol to obtain 19.8 g of salt. The obtained salt was dissolved in toluene (100 ml), heated to 35 ℃, a solution of citric acid (9.0 g, 0.047 mol) in ethanol (20 ml) was added dropwise, stirred for 1 hour, water (60 ml) was added, extraction was performed, a toluene layer was taken, and washed three times with water (10 ml), dried over anhydrous magnesium sulfate, and dried by spinning to obtain S-selenium octanoic acid: tan solid, 14.2 g, overall yield: 72.8% (calculated as theoretical S-selenium octanoic acid 19.5 g); purity: 98% (liquid phase area normalization method); melting point mp:84.9-86.8 ℃; optically active substanceInfrared IR νmax (KBr)/cm-1: 3026,2928,2898,1702,1427,1245,1205,944,732; hydrogen spectrum 1H NMR (600 mhz, cdcl 3), δ:3.92 (m, 1H, se-CH-), 3.33 (t, 2H, J=5.4 Hz, se-CH 2-), 3.00-2.95 (m, 1H, se-CH 2-CHH-), 2.53 (m, 1H, se-CH 2-CHH-), 2.39 (t, 2H, J=7.2 Hz, CH 2-CO-), 1.87-1.81 (m, 1H, CHH-CH2-CH2-CH 2-CO-), 1.78-1.72 (m, 1H, CHH-CH2-CH2-CH 2-CO-), 1.72-1.63 (m, 2H, CH2-CH 2-CO-), 1.53-1.43 (m, 2H, -CH2-CH2-CH 2-CO-); carbon spectrum 13C NMR (150 mhz, cdcl 3), δ:179.3,52.5,45.7,35.3,33.7,29.6,29.4,24.4; mass spectrometry ESI-MS:300.9 ([ M-H)]-)。
As can be seen from the above examples, the method of the invention can prepare single chiral selenocyanate with high total yield and purity, and has the advantages of mild reaction conditions, simple process, convenient operation and suitability for industrial application.
Example 4
Will [ example 1]]The mother liquor (containing S-selenooctanoic acid and S-selenooctanoic acid-R-methylbenzylamine salt) obtained by suction filtration is added dropwise with 1N hydrochloric acid to adjust the pH to 1-2. Water (60 mL) was added, the toluene layer was extracted, and washed three times with water (10 mL). The toluene solution was heated to reflux at 112℃and refluxed for 24 hours, and the solvent was concentrated. Recrystallizing with cyclohexane to obtain racemic selenocactanoic acid (16.4 g),
example 5
Will [ example 3]]In the process, cooling and suction filtration are carried out to obtain mother liquor (containing R-selenooctanoic acid and R-selenooctanoic acid-S-methylbenzylamine salt), and citric acid (9.6 g, dissolved in 20mL of water) is added dropwise for acidification. Water (60 mL) was added, the toluene layer was extracted, and washed three times with water (10 mL). The toluene solution was heated to reflux at 112℃for 20h and the solvent was concentrated. Recrystallizing with cyclohexane to obtain racemic selenocactanoic acid (17.3 g),
the embodiment shows that the method can recover the racemic selenium octoic acid, fully utilize the raw materials and reduce the production cost.
Claims (10)
1. The chiral resolution method of the selenium octanoic acid is characterized by comprising the following specific steps of:
step one: heating selenium Xin Suanrong in a first solvent to 25-80 ℃, and dropwise adding chiral methylbenzylamine, wherein the molar ratio of selenium octoic acid to chiral methylbenzylamine is 1:0.5-0.8, and the chiral methylbenzylamine isR-methylbenzylamine orSThe methylbenzylamine is separated out to obtain a tan solid, and the tan solid is cooled and filtered by suction to obtainR-salt of selenooctanoic acid with chiral methylbenzylamine orS-a salt of selenooctanoic acid with chiral methylbenzylamine; wherein the first solvent is toluene;
step two: recrystallizing the salt with a second solvent for 1 to 5 times, and purifying;
step three: dissolving the obtained salt in organic solvent, heating to 25-80deg.C, dropwise adding acidic solution, stirring for 0.5-1 hr, adding water, extracting, collecting organic solvent layer, washing with water, drying with anhydrous magnesium sulfate, and spin dryingRSelenium octoate orS-selenium octoate;
or dissolving the obtained salt in alkaline solution, washing with organic solvent, adding acidic solution dropwise to adjust pH to 1-2, precipitating a large amount of tan solid, vacuum filtering, and drying to obtain the final productRSelenium octoate orS-selenium octoate.
2. The method of claim 1, wherein in step one, the volume/mass ratio of the first solvent to the selenium octoate is 5-10 ml/g.
3. The method according to claim 1, wherein in the second step, the second solvent is toluene, acetonitrile or acetone, or a toluene/methanol mixed solvent, a toluene/ethanol mixed solvent, a toluene/isopropanol mixed solvent, a toluene/water mixed solvent, an acetonitrile/methanol mixed solvent, an acetonitrile/ethanol mixed solvent, an acetonitrile/isopropanol mixed solvent, an acetonitrile/water mixed solvent; in the mixed solvent, the volume ratio of the solvent before and after "/" is 1:0.2-5.
4. The method according to claim 1, wherein in step three, the organic solvent is toluene, methylene chloride, chloroform or ethyl acetate; the volume-mass ratio of the organic solvent to the obtained salt is 5-10 ml/g.
5. The method according to claim 1, wherein in the third step, the acid of the acidic solution is hydrochloric acid, acetic acid, citric acid, oxalic acid or tartaric acid, and the molar ratio of the obtained salt to the acid is 1:1-1.2; the solvent of the acid solution is water, methanol or ethanol, and the volume-mass ratio of the solvent to the acid is 1-5 ml/g.
6. The method according to claim 1, wherein in the third step, the alkali of the alkaline solution is sodium hydroxide or potassium hydroxide, and the molar ratio of the obtained salt to the alkali is 1:1-1.2; the solvent of the alkaline solution is water, methanol or ethanol, and the volume-mass ratio of the solvent to the alkali is 1-5 ml/g.
7. The method according to claim 1, wherein in the first step, the mother liquor after suction filtration is used for recovering the selenium octanoic acid by the following method: acidifying the filtrate, washing with water, and collecting the organic layer; and then heating the organic layer for reaction under normal pressure, concentrating the solvent, and recrystallizing to obtain the selenium octoic acid.
8. The method of claim 7, wherein the acidification is to adjust the pH of the filtrate to 1-3 with an acid selected from the group consisting of hydrochloric acid, acetic acid, sulfuric acid, citric acid, oxalic acid, tartaric acid.
9. The method of claim 7, wherein the heating reaction temperature is 60 to 120 ℃ and the heating reaction time is 6 to 24 hours.
10. The process of claim 7, wherein the solvent-concentrated product is recrystallized from cyclohexane.
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| CN102442994A (en) * | 2011-10-31 | 2012-05-09 | 江苏同禾药业有限公司 | Racemization method of S-lipoic acid and preparing method of R-lipoic acid |
| CN102993167A (en) * | 2012-11-07 | 2013-03-27 | 台州职业技术学院 | Preparation method of selenium caprylate |
| WO2013141417A1 (en) * | 2012-03-20 | 2013-09-26 | 에스지글로벌주조 주식회사 | Functional makgeolli with improved radioactive strontium discharge and antioxidant activity, containing selenium solution, and preparation method thereof |
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| CN102442994A (en) * | 2011-10-31 | 2012-05-09 | 江苏同禾药业有限公司 | Racemization method of S-lipoic acid and preparing method of R-lipoic acid |
| WO2013141417A1 (en) * | 2012-03-20 | 2013-09-26 | 에스지글로벌주조 주식회사 | Functional makgeolli with improved radioactive strontium discharge and antioxidant activity, containing selenium solution, and preparation method thereof |
| CN102993167A (en) * | 2012-11-07 | 2013-03-27 | 台州职业技术学院 | Preparation method of selenium caprylate |
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