CN115032376B - Method for detecting components of mosquito-repelling and itching-relieving composition - Google Patents
Method for detecting components of mosquito-repelling and itching-relieving composition Download PDFInfo
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- 208000003251 Pruritus Diseases 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 title claims abstract description 26
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- 230000008859 change Effects 0.000 claims abstract description 49
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- 230000008961 swelling Effects 0.000 claims abstract description 26
- 241000255925 Diptera Species 0.000 claims abstract description 24
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- 230000000694 effects Effects 0.000 description 17
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- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
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Abstract
The invention relates to the technical field of component detection, and particularly relates to a method for detecting components of a mosquito-repellent itching-relieving composition. The method comprises the following steps: acquiring the humidity level of each subarea after the mosquito-repellent itching-relieving composition is smeared on the subareas, so as to obtain the humidity change; combining the mosquito-repelling itching-relieving composition with a matrix to obtain a new composition, and obtaining the residence time of mosquitoes after the new composition is smeared so as to obtain the abnormal degree; acquiring the red and swelling eliminating degree of the new composition after being smeared, and acquiring smearing quality based on the red and swelling eliminating degree, abnormal degree and humidity change; the concentration ratio of the mosquito-repelling and itching-relieving composition is obtained, the smearing quality and the concentration ratio, the redness and swelling eliminating degree, the abnormal degree and the humidity change of the corresponding mosquito-repelling and itching-relieving composition are utilized to train the first-class weighting support vector machine, so that the predicted value of the smearing quality of the new composition to be detected is obtained according to the first-class weighting support vector machine, component detection of the mosquito-repelling and itching-relieving composition is completed, the detection efficiency is high, and the detection evaluation result is more accurate.
Description
Technical Field
The invention relates to the technical field of component detection, and particularly relates to a method for detecting components of a mosquito-repellent itching-relieving composition.
Background
The mosquito repellent ester is an effective component for repelling mosquitoes, can be used as a composition for repelling mosquitoes and relieving itching after being combined with the maleic acid dimethylinddine, the composition is generally in the forms of liquid or ointment and the like, the composition needs a matrix, and for different matrices, the effect generated after the composition is applied is different; at present, a method for detecting and analyzing components of the mosquito-repelling and itching-relieving composition by objective methods is lacked, especially the detection of an intermediate test link is usually to simply analyze the consistency of the medicine, neglect the influence of errors caused by different matrixes, and have low accuracy and reliability.
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide a method for detecting components of a mosquito-repellent itching-relieving composition, which comprises the following steps:
dividing a test skin area of a subject into a plurality of subareas, smearing a mosquito-repellent itching-relieving composition on the test skin area of the subject, acquiring the humidity level of each subarea of the test skin area of the subject after smearing at each sampling moment, acquiring humidity stability according to the humidity levels of all the subareas at each sampling moment, and acquiring the humidity change of the test skin area of the subject based on the humidity stability at all the sampling moments;
combining the mosquito-repelling and itching-relieving composition with a substrate to obtain a new composition, smearing the new composition on a test skin area of a subject, obtaining mosquito retention time corresponding to the test skin area of the subject after the new composition is smeared within a period of time, and obtaining abnormal degree based on the mosquito retention time;
applying the new composition to a test skin area of a subject to obtain a degree of redness reduction, and obtaining an application quality based on the degree of redness reduction, the degree of abnormality, and the change in moisture; and obtaining the concentration ratio of the mosquito-repellent itching-relieving composition in each new composition corresponding to the smearing quality, training a weighted support vector machine according to the smearing quality and the concentration ratio of the mosquito-repellent itching-relieving composition corresponding to the smearing quality, the redness and swelling eliminating degree, the abnormal degree and the humidity change, and obtaining a predicted value of the smearing quality of the new composition to be detected according to the trained weighted support vector machine, so as to complete component detection of the mosquito-repellent itching-relieving composition.
Preferably, the step of training the weighted support vector machine includes:
the method comprises the steps of obtaining mosquito repellent and itching relieving compositions of mosquito repellent ester and difenidine maleate in different concentration ratios, combining the mosquito repellent and itching relieving compositions and a substrate based on different concentration ratios to obtain a plurality of new compositions, obtaining humidity change and abnormal degree corresponding to each new composition, clustering all the new compositions based on the difference distance between the humidity change and the abnormal degree between the different new compositions to obtain a plurality of categories, and distributing weights to the new compositions in the categories based on the average humidity change and the average abnormal degree of the new compositions in each category;
and training a weighted support vector machine according to the smearing quality of the new composition and the corresponding concentration ratio, the red and swollen elimination degree, the abnormal degree and the humidity change of the new composition and the weight of the new composition.
Preferably, the step of obtaining the humidity stability according to the humidity levels of all the sub-areas at each sampling time includes:
and forming humidity data record values by the humidity levels of all the subregions at each sampling moment, and acquiring the variance of the humidity data record values, wherein the humidity stability and the variance are in a negative correlation relationship.
Preferably, the step of deriving the change in moisture content of the test skin area of the subject based on the moisture stability at all sampling times comprises:
acquiring the maximum value and the median value of the humidity stability at all sampling moments; and obtaining the humidity change according to the difference value of the maximum value and the median value.
Preferably, the step of obtaining the degree of abnormality includes:
constructing a dwell time record value by using the mosquito dwell time in a period of time, and acquiring the range of the dwell time record value and the median of the dwell time record value, wherein the ratio of the range to the median is the abnormal degree.
Preferably, the step of applying the new composition to a test skin area of a subject to obtain a degree of redness reduction comprises:
dividing the red and swollen degree of the mosquito bite into a plurality of grades by a professional, and recording the grade of the initial red and swollen degree of a tested skin area of the tested subject after the mosquito bite;
obtaining a grade of the degree of redness of the new composition after application to a test skin area of a subject over a period of time, calculating a ratio of the grade of the degree of redness to the grade of the initial degree of redness, the degree of redness reduction being inversely related to the ratio.
Preferably, the step of obtaining the smearing quality based on the degree of red and swollen elimination, the degree of abnormality and the humidity change includes:
the coating mass is calculated as:
wherein,
indicating the smearing quality;
indicating the degree of red and swelling elimination;
indicating the degree of abnormality;
indicating a change in humidity;
a correction coefficient indicating a degree of redness and swelling;
representing a cosine function;
representing a hyperbolic tangent function.
The invention has the following beneficial effects: by analyzing the new composition after the mosquito-repellent itching-relieving composition is combined with the matrix, the redness and swelling eliminating degree, the abnormal degree and the humidity change are obtained according to the conditions of the tested skin area of the subject before and after the new composition is applied, the application quality of the new composition is obtained by combining the redness and swelling eliminating degree, the abnormal degree and the humidity change, and the result is more reliable through multi-aspect data acquisition and calculation; the new composition formed by the mosquito-repelling and itching-relieving composition under different concentration ratios is used as a sample, sample data corresponding to each sample is used for training a weighted support vector machine so as to obtain the smearing quality of the samples under different concentration ratios, whether the ratio result of the mosquito-repelling and itching-relieving composition at the moment is in accordance with the expectation or not is judged based on the smearing quality, the detection efficiency is improved, and the accuracy of the detection evaluation result is ensured.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions and advantages of the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a flow chart of a method for detecting components of a mosquito-repellent itching-relieving composition according to an embodiment of the present invention.
Detailed Description
In order to further illustrate the technical means and effects of the present invention adopted to achieve the predetermined objects, the following detailed description, the specific implementation manner, the structure, the characteristics and the effects thereof of the method for detecting the components of the mosquito-repellent itching-relieving composition according to the present invention are provided with the accompanying drawings and the preferred embodiments. In the following description, different "one embodiment" or "another embodiment" refers to not necessarily the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The method is suitable for analyzing the components of the mosquito-repelling and itching-relieving composition under different concentration ratios, the smearing quality of the new composition is calculated based on humidity change, redness and swelling eliminating degree, smearing abnormal degree and the like of a tested skin area of a subject after the mosquito-repelling and itching-relieving composition and the new composition are smeared, a first weighting type support vector machine is trained according to samples corresponding to the mosquito-repelling and itching-relieving composition under different concentration ratios, the smearing quality of the mosquito-repelling and itching-relieving composition under different concentration ratios can be obtained based on the trained first weighting type support vector machine, and whether the component ratios of the mosquito-repelling and itching-relieving composition meet expectations or not is further obtained; the accuracy of analyzing the components of the mosquito-repellent itching-relieving composition is improved.
The following specific scheme of the method for detecting the components of the mosquito-repellent itching-relieving composition provided by the invention is concretely described by combining the accompanying drawing.
Referring to fig. 1, a flow chart of a method for detecting components of a mosquito-repelling and itching-relieving composition according to an embodiment of the present invention is shown, and the method includes the following steps:
step S100, dividing a test skin area of a subject into a plurality of sub-areas, smearing the mosquito-repelling and itching-relieving composition on the test skin area of the subject, acquiring the humidity level of each sub-area of the test skin area of the subject at each sampling moment after smearing, acquiring humidity stability according to the humidity levels of all the sub-areas at each sampling moment, and acquiring the humidity change of the test skin area of the subject based on the humidity stability at all the sampling moments.
Specifically, the effective mosquito-repellent component is mosquito repellent ester, and when the mosquito repellent ester is combined with the maleic acid dimetindedine, the mosquito repellent itching-relieving composition is formed; when the effect of the mosquito-repellent itching-relieving composition is tested, wiping and humidity measurement are often required to be carried out on a test skin area of a subject, so that the situation that the mosquito-repellent itching-relieving composition is difficult to absorb due to sweat and the like is avoided as much as possible; when the mosquito-repellent itching-relieving composition is applied to the tested skin area of a subject, the humidity of the applied area is kept to be smooth as much as possible.
In the embodiment of the invention, a test skin area of a subject is divided into 3 sub-areas, the humidity data of each sub-area is collected and analyzed, and the humidity data is classified by related workers, all humidity conditions are divided into 10 humidity levels, and the humidity level corresponding to each sub-area is obtained; the humidity condition is acquired by adopting an infrared thermal imaging technology, the humidity condition of each subregion is acquired for multiple times in the same time period, namely, a plurality of sampling moments are provided in a period of time, the 3 subregions are acquired at each sampling moment according to the humidity grade, and the interval of humidity acquisition is 10 seconds every time.
Further, the humidity levels corresponding to all the sub-areas at each sampling time are combined into a humidity data record value, the humidity change condition of the test skin area of the subject is obtained according to the humidity data record value, the variance of the humidity data record value is obtained, the humidity stability corresponding to the skin of the subject at each sampling time is obtained according to the variance of the humidity data record value, and the humidity stability is calculated as follows:
wherein,
representing the humidity stability at any sampling time;
calculating the variance of the humidity data record value corresponding to the sampling time;
representing an exponential function;
the humidity correction coefficient is set by the practitioner.
Preferably, the humidity correction coefficient is set in the embodiment of the invention
In other embodiments, the implementer may make adjustments based on measurement errors or actual conditions.
Further, acquiring the corresponding humidity stability of the tested skin area of the subject at all sampling moments after the mosquito-repellent itching-relieving composition is smeared on the tested skin area of the subject, acquiring the maximum value and the median of the corresponding humidity stability at all sampling moments, acquiring the humidity change of the skin of the subject according to the maximum value and the median, wherein the specific calculation of the humidity change is as follows:
wherein,
indicating a change in humidity;
the maximum value of the humidity stability corresponding to all sampling moments is represented;
representing the median value of the humidity stability for all sampling instants.
When the difference between the maximum value and the median value of the corresponding humidity stability at all sampling moments is larger, the change of the humidity at the moment is larger, namely the humidity is uneven in the action process of the current mosquito-repellent itching-relieving composition, and the effect of the applied mosquito-repellent itching-relieving composition is possibly influenced by abnormal sweat.
Step S200, combining the mosquito-repelling itching-relieving composition with a matrix to obtain a new composition, smearing the new composition on a test skin area of a subject, obtaining mosquito retention time corresponding to the test skin area of the subject after the new composition is smeared within a period of time, and obtaining abnormal degree based on the mosquito retention time.
Specifically, the product for repelling mosquitoes and relieving itching used in normal life is a product formed by combining the mosquito-repelling and relieving itching composition with the matrix, but the matrix possibly causes the mosquito-repelling and relieving itching composition to be difficult to volatilize so as to influence the mosquito-repelling effect, so that the mosquito-repelling effect of the novel composition formed by combining the mosquito-repelling and relieving itching composition with the matrix is analyzed, and the mosquito-repelling effect of the novel composition is reflected by the retention time of mosquitoes in the embodiment of the invention.
The mosquito repelling test is to measure the time of mosquito staying in the skin area of the test subject in the mosquito net box body in the environment, the effective smearing time of the normal mosquito repelling and itching relieving product is taken as a sampling time period in the embodiment of the invention, and the time that the mosquito stays in the skin area of the test subject every time is recorded in the sampling time periodDwell time of the field, whereby dwell time recorded values are constructed from the dwell time of each dwell
(ii) a Wherein,
means the residence time of mosquitoes for the first time in the test skin area of the subject;
to indicate the mosquito
The residence time of the secondary residence in the test skin area of the subject.
In order to prevent mosquitoes from obviously biting the skin of the subject, the retention time of each time is 7s as an upper limit, and the retention time exceeding 7s is calculated according to 7 s; obtaining the median and the range of the residence time area, and obtaining the abnormal degree of the new composition based on the median and the range, wherein the abnormal degree is as follows:
wherein,
indicating the degree of abnormality of the new composition;
represents the range of recorded values for residence time;
the median of the recorded values for residence time is indicated.
When the data phase difference in the stay time record value is larger, the range of the stay time record value is larger; the median is used to represent the very poor normalized base, the less anomaly when the new composition is applied better after the mosquito repellent antipruritic composition is combined with the substrate.
Step S300, smearing the new composition on a test skin area of a subject to obtain the red and swollen elimination degree, and obtaining smearing quality based on the red and swollen elimination degree, the abnormal degree and humidity change; the concentration ratio of the mosquito-repellent itching-relieving composition in the new composition corresponding to each smearing mass is obtained, the smearing mass and the concentration ratio, the red and swelling eliminating degree, the abnormal degree and the humidity change of the mosquito-repellent itching-relieving composition corresponding to the smearing mass are utilized to train a first weighting support vector machine, and the predicted value of the smearing mass of the new composition to be detected is obtained according to the trained first weighting support vector machine, so that the component detection of the mosquito-repellent itching-relieving composition is completed.
In particular, considering that another effect of the mosquito repellent antipruritic composition is elimination of red swelling caused by mosquito bites, the effect of the new composition is evaluated by the degree of elimination of red swelling after application of the new composition; in the embodiment of the invention, the red and swollen degree of the mosquito bite is firstly classified based on artificial experience, the classification is carried out into ten grades according to factors such as the bulge degree or the red and swollen area of the mosquito bite, and then the red and swollen degree at the moment is recorded in a period of time after the new composition is applied to the red and swollen area of the mosquito bite; obtaining the red and swollen elimination degree of the new composition based on the level of the initial red and swollen degree after the mosquito bites and the level of the red and swollen elimination degree at the moment, wherein the red and swollen elimination degree is calculated as follows:
wherein,
indicating the degree of red and swelling elimination;
a scale representing the degree of initial redness after a mosquito bite;
grade representing the degree of redness after application of the novel compositionOtherwise.
Acquiring the humidity change after the mosquito-repellent and itching-relieving composition is smeared in the step S100, acquiring the abnormal degree of a new composition after the mosquito-repellent and itching-relieving composition is combined with the substrate in the step S200, and evaluating the smearing quality of the new composition by combining the redness and swelling eliminating degree of the new composition, wherein the smearing quality is calculated as follows:
wherein,
indicating the smearing quality;
indicating the degree of red and swelling elimination;
indicating the degree of abnormality;
indicating a change in humidity;
a correction coefficient indicating a degree of redness and swelling;
representing a cosine function;
a hyperbolic tangent function is represented for normalization.
Preferably, the correction coefficient of the degree of red swelling in the embodiment of the present invention
(ii) a Wherein,
indicating the currently desired degree of redness and swelling.
The new composition, after being combined with the base material, applied to the test skin area of the subject, shows a more similar degree of redness and swelling elimination as compared to the ideal degree of redness and swelling elimination, and a smaller degree of abnormality and humidity change, indicating that the new composition is applied in a better quality.
Further, it is determined whether the new composition is a qualified sample based on the application quality of the new composition, i.e. the application quality of the new composition to be obtained is compared with a standard application quality, which is set by the practitioner according to experience. In the embodiment of the invention, a trained weighted support vector machine WOC-SVM is adopted in the method for judging whether the new composition to be detected is a qualified sample, the concentration of mosquito repellent ester, the concentration of difinddine maleate, the humidity change, the red and swelling eliminating degree and the abnormal degree of the mosquito repellent effect corresponding to the new composition to be detected are input into the weighted support vector machine WOC-SVM, the predicted smearing quality is output by the weighted support vector machine WOC-SVM, whether the quality of the new composition to be detected reaches the standard or not is judged according to the predicted smearing quality, and whether the components of the mosquito repellent itching-relieving composition meet the expectation or not is further detected, so that the effect boundary of the mosquito repellent itching-relieving composition is searched, and the research and development of the components of the mosquito repellent itching-relieving composition are guided.
Weighting training data of a support vector machine WOC-SVM as historical data in the development process of the mosquito-repelling and itching-relieving composition, wherein each sample is a new composition, and the mosquito-repelling effect of the new compositions is different due to different concentration ratios of the mosquito-repelling and itching-relieving composition of the mosquito repellent ester and the difindadine maleate; a weighted support vector machine WOC-SVM is a single classifier, and can search a hyperplane in a combined space of mosquito repelling and itching relieving composition components and a mosquito repelling effect of a subject after smearing, divide positive examples in each sample, and judge whether a new composition can achieve a decision of good enough smearing quality or not based on the hyperplane. A sample of the weighted first-class support vector machine WOC-SVM in a circle is regarded as a positive sample, and a weighted first-class support vector machine WOC-SVM classifier is adopted in the embodiment of the invention to find out reasonable components of the mosquito-repelling and itching-relieving composition, so that the effect boundary of the mosquito-repelling and itching-relieving composition is determined.
In the training process of the weighted support vector machine WOC-SVM, in order to obtain a more effective hyperplane, weighted correction needs to be carried out on each sample, the sample is a new composition of the mosquito-repellent itching-relieving composition and the matrix in different concentration ratios, and the different concentration ratios refer to the concentration ratios of the mosquito-repellent ester and the difindedine maleate; the method for acquiring the weight corresponding to each sample comprises the following steps:
considering that the humidity change has great influence on the smearing quality of the new composition formed by combining the mosquito-repellent itching-relieving composition and the matrix, the new composition in all concentration ratios is classified by combining the humidity characteristics and the abnormal degree after smearing; obtaining the difference distance between the new compositions at every two concentration ratios, wherein the difference distance is calculated as follows:
wherein,
is shown as
Novel composition at various concentration ratios and
differential distance between new compositions at various concentration ratios;
is shown as
The humidity of the new composition after being coated changes according to the concentration ratio;
is shown as
The humidity change of the new composition after being coated under various concentration ratios;
is shown as
Degree of abnormality of the new composition at each concentration ratio;
denotes the first
Degree of abnormality of the new composition at each concentration ratio.
The classification method in the embodiment of the invention adopts k-means clustering, the k value of the clustering is set to be 4, namely, the new compositions under all concentration ratios are divided into 4 categories, and the k-means clustering method is the prior known technology and is not repeated.
Further, distributing weight to the new compositions in each category, setting a comparison threshold, obtaining average humidity change and average abnormal degree corresponding to all the new compositions in each category, and when the average humidity change and the average abnormal degree are smaller than the comparison threshold, the mosquito repellent effect of the new compositions in the category is better, and the weight of the new compositions in the category is 1; when the average humidity change and the average abnormal degree are both larger than the comparison threshold value, the mosquito repelling effect of the new composition in the category is very poor, and the weight of the new composition in the category is 4; when the average humidity change is greater than the comparison threshold and the average degree of abnormality is less than the comparison threshold, which may be affected by sweat from the test skin area of the subject, the new composition in the category is weighted 2.5; when the average humidity change is less than the comparison threshold and the average degree of abnormality is greater than the comparison threshold, the problem of the mosquito repellent and itching relieving composition in the new composition is present, and the weight of the new composition in the category is 2.5.
Preferably, the comparison threshold is set to 0.4 in the embodiment of the present invention.
Therefore, corresponding weights are distributed to the new compositions of each category, so that the training of the abnormal samples can be emphasized more during the subsequent training of the support vector machine of the weighted type, and the support vector machine of the weighted type can better learn the characteristics of the abnormal samples. And training a weighted support vector machine by combining the weight of the new composition under each concentration ratio with the corresponding smearing quality, humidity change, red and swelling eliminating degree and abnormal degree of mosquito repelling effect of each new composition.
An implementer can obtain a predicted value of the smearing mass of the new composition under different concentration ratios based on a weighted support vector machine after training is completed, and can reflect the concentration ratio of the mosquito repellent ester and the difindidine maleate in the mosquito repellent and itching relieving composition and whether the mosquito repellent effect of the mosquito repellent and itching relieving composition meets the expectation or not according to the predicted value of the smearing mass.
In conclusion, in the embodiment of the invention, the smearing quality of the mosquito-repellent and itching-relieving composition is analyzed through the humidity change, abnormal degree and red and swelling eliminating degree of a tested skin area of a subject after the mosquito-repellent and itching-relieving composition is smeared, a weighted first-class support vector machine is further trained according to samples corresponding to the mosquito-repellent and itching-relieving composition under different concentration ratios, a predicted value of the smearing quality of a new composition under different concentration ratios is obtained through the trained weighted first-class support vector machine, and then the concentration ratio of the mosquito-repellent ester and the difindedine maleate in the mosquito-repellent and itching-relieving composition and whether the mosquito-repellent effect of the mosquito-repellent and itching-relieving composition meet expectations are reflected; the detection efficiency is higher and the analysis result is accurate.
It should be noted that: the precedence order of the above embodiments of the present invention is only for description, and does not represent the merits of the embodiments. In addition, the processes depicted in the accompanying figures do not necessarily require the particular order shown, or sequential order, to achieve desirable results. In some embodiments, multitasking and parallel processing may also be possible or may be advantageous.
The embodiments in the present specification are described in a progressive manner, and the same and similar parts among the embodiments are referred to each other, and each embodiment focuses on the differences from the other embodiments.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that are within the spirit of the present invention are intended to be included therein.
Claims (2)
1. The method for detecting the components of the mosquito-repellent itching-relieving composition is characterized by comprising the following steps:
dividing a test skin area of a subject into a plurality of subareas, smearing a mosquito-repellent and itching-relieving composition on the test skin area of the subject, acquiring the humidity level of each subarea of the smeared test skin area of the subject at each sampling moment, acquiring humidity stability according to the humidity levels of all the subareas at each sampling moment, and acquiring the humidity change of the test skin area of the subject based on the humidity stability at all the sampling moments;
combining the mosquito-repelling and itching-relieving composition with a substrate to obtain a new composition, smearing the new composition on a test skin area of a subject, obtaining mosquito retention time corresponding to the test skin area of the subject after the new composition is smeared within a period of time, and obtaining abnormal degree based on the mosquito retention time;
applying the new composition to a test skin area of a subject to obtain a degree of redness reduction, and obtaining an application quality based on the degree of redness reduction, the degree of abnormality, and the change in moisture; acquiring the concentration ratio of the mosquito-repellent itching-relieving composition in each new composition corresponding to the smearing quality, training a weighted support vector machine by using the smearing quality and the concentration ratio, the red and swollen degree, the abnormal degree and the humidity change of the mosquito-repellent itching-relieving composition corresponding to the smearing quality, and acquiring a predicted value of the smearing quality of the new composition to be detected according to the trained weighted support vector machine so as to finish component detection of the mosquito-repellent itching-relieving composition;
wherein, the step of obtaining the humidity stability according to the humidity levels of all the sub-areas at each sampling time comprises:
forming humidity data record values by the humidity levels of all the sub-areas at each sampling moment, and acquiring the variance of the humidity data record values, wherein the humidity stability and the variance are in a negative correlation relationship;
the step of deriving the change in moisture content of the test skin area of the subject based on the moisture stability at all sampling times comprises:
acquiring the maximum value and the median value of the humidity stability at all sampling moments; obtaining the humidity change according to the difference value between the maximum value and the median value;
the step of obtaining the degree of abnormality includes:
establishing a retention time record value according to the mosquito retention time in a period of time, and acquiring the range of the retention time record value and the median of the retention time record value, wherein the ratio of the range to the median is the abnormal degree;
the step of applying the new composition to a test skin area of a subject to obtain a degree of redness reduction comprises:
dividing the red and swollen degree of the mosquito bite into a plurality of grades by a professional, and recording the grade of the initial red and swollen degree of a tested skin area of the tested subject after the mosquito bite;
obtaining the grade of the red and swollen degree of the new composition after the new composition is smeared on the test skin area of a subject for a period of time, and calculating the ratio of the grade of the red and swollen degree to the grade of the initial red and swollen degree, wherein the red and swollen elimination degree and the ratio have a negative correlation;
the step of obtaining the smearing quality based on the degree of redness and swelling, the degree of abnormality, and the change in humidity includes:
the coating mass was calculated as:
wherein,
indicating the smearing quality;
indicating the degree of red and swelling elimination;
indicating the degree of abnormality;
indicating a change in humidity;
a correction coefficient indicating a degree of redness and swelling;
representing a cosine function;
representing a hyperbolic tangent function.
2. The method for detecting the components of the mosquito-repellent itching-relieving composition according to claim 1, wherein the step of training a weighted support vector machine comprises the steps of:
the method comprises the steps of obtaining mosquito repellent and itching relieving compositions under different concentration ratios of mosquito repellent ester and difindine maleate, combining the mosquito repellent and itching relieving compositions under different concentration ratios with a substrate to obtain multiple new compositions, obtaining humidity change and abnormal degree corresponding to each new composition, clustering all the new compositions based on the difference distance of the humidity change and the abnormal degree between the different new compositions to obtain multiple categories, and distributing weights to the new compositions in the categories based on the average humidity change and the average abnormal degree of the new compositions in each category;
and training a weighted support vector machine according to the smearing quality of the new composition and the corresponding concentration ratio, the red and swollen elimination degree, the abnormal degree and the humidity change of the new composition and the weight of the new composition.
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