CN114993581B - Pipeline air tightness detection device, method and system - Google Patents
Pipeline air tightness detection device, method and system Download PDFInfo
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- CN114993581B CN114993581B CN202210918976.1A CN202210918976A CN114993581B CN 114993581 B CN114993581 B CN 114993581B CN 202210918976 A CN202210918976 A CN 202210918976A CN 114993581 B CN114993581 B CN 114993581B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M3/00—Investigating fluid-tightness of structures
- G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
- G01M3/26—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
- G01M3/28—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables or tubes; for pipe joints or seals; for valves ; for welds
- G01M3/2807—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables or tubes; for pipe joints or seals; for valves ; for welds for pipes
- G01M3/2815—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables or tubes; for pipe joints or seals; for valves ; for welds for pipes using pressure measurements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01G—WEIGHING
- G01G17/00—Apparatus for or methods of weighing material of special form or property
- G01G17/04—Apparatus for or methods of weighing material of special form or property for weighing fluids, e.g. gases, pastes
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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Abstract
The invention relates to the field of cell sorting pipelines, in particular to a pipeline airtightness detection device, method and system. The gas tightness detection is carried out by compressing each path of gas through the movement of liquid, and the gas tightness detection is carried out by fully combining the mutual pushing acting force of the liquid and the gas, so that the gas tightness detection without manual intervention is realized, the aseptic requirement of a pipeline panel system is ensured, and the full-automatic pipeline gas tightness detection effect is realized. Meanwhile, the introduction of the bubble sensor and the weighing sensor ensures the accuracy and correctness of the air tightness test.
Description
Technical Field
The invention relates to a cell sorting pipeline, in particular to a pipeline air tightness detection device, method and system.
Background
At present, cell therapy has become a new emerging therapeutic approach, instruments or equipment related to cell therapy also come into existence, a cell separation device in the instruments or equipment related to cell therapy plays an important role therein, a liquid path system or a pipeline system in the cell separation device is an indispensable condition for ensuring that cell processing is in a sterile environment, the liquid path system or the pipeline system comprises a plurality of pipelines, liquid (solution containing cells) of a liquid bag used in cell separation can flow to required pipeline ports (including a liquid inlet and a liquid outlet) through the liquid path system or the pipeline system, each pipeline port can be controlled by a control valve, pipelines enclosed by the control valves form the liquid path system or the pipeline system, the air tightness of the liquid path system or the pipeline system is of vital importance, once leakage occurs in the liquid path system or the pipeline system, the liquid seeps out, the totally closed and sterile requirements in the cell processing process cannot be ensured, most of the existing schemes are that air inflation is performed to one of the pipelines in the liquid path system or the pipeline system manually, then the air leakage amount is measured through another pipeline port, whether the requirement of manual judgment is met, the subjective and the judgment of the leakage is high in accuracy, and the detection cost is greatly reduced.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a pipeline airtightness detection device which injects a fixed amount of liquid into a pipeline panel system, arranges a peristaltic pump and pressure sensors arranged in front of and behind the peristaltic pump in the pipeline panel system, enables the injected liquid to flow through the peristaltic pump through a pipeline, and judges the airtightness of the pipeline panel system by using the pressure sensors through the rotation of the peristaltic pump.
The technical scheme adopted by the invention for solving the technical problems is as follows: a pipeline air tightness detection device comprises a peristaltic pump and a pipeline system, wherein the peristaltic pump is arranged at one end of the pipeline system and is used for urging liquid and gas in the pipeline system, and a plurality of passages are arranged in the pipeline system;
furthermore, a plurality of control valves are arranged on the pipeline system and are used for controlling the communication and the closing of different passages of the pipeline system; need open the control valve before carrying out the gas tightness and detecting, carry out the feed liquor, close the control valve of feed liquor department or play liquid department again after the feed liquor is accomplished, carry out the gas tightness detection of gas circuit through the peristaltic pump.
Furthermore, the pipeline system is also provided with a pressure sensor, and the pressure sensor is arranged between the peristaltic pump and the plurality of passages in the pipeline system and is used for detecting the pressure of the pipeline from the peristaltic pump to the plurality of passages in the pipeline system. The pressure sensor is matched with the peristaltic pump, and the peristaltic pump pushes liquid in the pipeline, so that gas in the pipeline is extruded simultaneously, pressure is generated in the pipeline, and the pressure in the pipeline can be detected through the pressure sensor.
As an improvement of the above technical scheme, the pipeline system comprises an upper pipeline and a lower pipeline, wherein the upper pipeline and the lower pipeline are respectively arranged at two sides of the peristaltic pump and are driven by the peristaltic pump;
further, the upper pipeline and the lower pipeline are both provided with pressure sensors, and the pressure sensors are communicated with a pipeline system.
As a further improvement of the above technical solution, the upper pipeline is connected to the liquid bag, the lower pipeline is connected to the centrifuge cup, the pressure sensors include a first pressure sensor and a second pressure sensor, the first pressure sensor and the second pressure sensor are respectively disposed at two sides of the peristaltic pump, and the first pressure sensor is used for detecting the pressure in the pipeline from the peristaltic pump to the liquid bag; the second pressure sensor is used for detecting the pressure in the pipeline between the peristaltic pump and the centrifugal cup.
As an application of the above-described pipe air-tightness detection apparatus, there is also a pipe air-tightness detection method including:
opening a control valve corresponding to a liquid inlet connected with a liquid bag and a control valve corresponding to a liquid outlet in a pipeline system to be tested;
starting a peristaltic pump, enabling the liquid in the liquid bag to flow to a pipeline path of the liquid outlet to pass through the peristaltic pump and a pressure sensor, and closing the peristaltic pump after detecting that the pipeline path is full of liquid; the tubing system comprises the tubing path;
and starting the peristaltic pump after closing all control valves in the pipeline system, and determining a pipeline airtightness result of the pipeline system according to the rotation direction of the peristaltic pump, a preset threshold corresponding to the rotation direction and a pressure parameter in the pipeline path measured by a pressure sensor in the rotation process.
As an improvement of the above technical solution, the starting of the peristaltic pump after closing all the control valves in the pipeline system, and determining the pipeline airtightness result of the pipeline system according to the rotation direction of the peristaltic pump, the preset threshold corresponding to the rotation direction, and the pressure parameter in the pipeline path measured by the pressure sensor during the rotation process, include:
the preset threshold comprises the first threshold and a second threshold; the pressure parameters comprise the first limit pressure value and a second limit pressure value; the pressure sensors include the first pressure sensor and a second pressure sensor;
after the rotation direction of the peristaltic pump is set to be the clockwise direction, starting the peristaltic pump to rotate in the clockwise direction, and acquiring a first threshold value corresponding to the clockwise direction;
determining an upper pipeline airtight result corresponding to an upper pipeline in the pipeline system according to the first threshold and a first limit pressure value measured by a first pressure sensor;
stopping the rotation of the peristaltic pump, changing the rotation direction of the peristaltic pump into the anticlockwise direction, starting the peristaltic pump to rotate in the anticlockwise direction, and acquiring the second threshold corresponding to the anticlockwise direction;
determining a lower pipeline airtight result corresponding to a lower pipeline in the pipeline system according to the second threshold and a second limit pressure value measured by the second pressure sensor;
and determining the result of the pipeline airtightness according to the result of the upper pipeline airtightness and the result of the upper pipeline airtightness.
As a further improvement of the above technical solution, the determining, according to the first threshold and a first limit pressure value measured by a first pressure sensor, an upper pipeline air-tight result corresponding to an upper pipeline in the pipeline system includes:
performing limit value identification on all pressure values measured by the first pressure sensor in the rotation process of the peristaltic pump, and identifying the first limit pressure value;
comparing the first limit pressure value to the first threshold value;
when the first limit pressure value is smaller than the first threshold value, determining that the upper pipeline air-tight result is unqualified;
and when the first limit pressure value is larger than or equal to the first threshold value, determining that the upper pipeline airtight result is qualified.
Similarly, the determining, according to the second threshold and the second extreme pressure-limiting value measured by the second pressure sensor, a lower pipeline air-tight result corresponding to a lower pipeline in the pipeline system includes:
identifying the limit value of all pressure values measured by the second pressure sensor in the rotation process of the peristaltic pump, and identifying the second limit value;
comparing the second limit voltage value with the second threshold value;
when the second limit pressure value is smaller than the second threshold value, determining that the lower pipeline air-tight result is unqualified;
and when the second limit pressure value is greater than or equal to the second threshold value, determining that the lower pipeline airtight result is qualified.
As an improvement of the foregoing technical solution, the determining, according to the first threshold and a first limit pressure value measured by the first pressure sensor, an upper pipeline air-tight result corresponding to an upper pipeline in the pipeline system includes:
acquiring a threshold duration corresponding to the first threshold;
measuring the time length for the first limit pressure value to reach the first threshold value through a first pressure sensor, and recording the time length as the measuring time length;
when the measuring duration is less than the threshold duration, determining that the upper pipeline airtight result is qualified;
and when the measurement duration is greater than or equal to the threshold duration, determining that the upper pipeline airtight result is unqualified.
Similarly, the determining, according to the second threshold and the second extreme pressure-limiting value measured by the second pressure sensor, a lower pipeline airtightness result corresponding to a lower pipeline in the pipeline system includes:
acquiring a threshold duration corresponding to the second threshold;
measuring the time length of the second limit pressure value reaching the second threshold value through a second pressure sensor, and recording the time length as the measurement time length;
when the measurement duration is less than the threshold duration, determining that the lower pipeline air-tight result is qualified;
and when the measurement duration is greater than or equal to the threshold duration, determining that the lower pipeline air-tight result is unqualified.
As a further improvement of the above technical solution, the starting of the peristaltic pump to make a pipeline path from the liquid in the liquid bag to the liquid outlet pass through the peristaltic pump and the pressure sensor, and the closing of the peristaltic pump after detecting that the pipeline path is full of liquid includes:
when detecting that the first bubble sensor acquires a liquid inlet state, controlling the peristaltic pump to continue rotating; the first bubble sensor is arranged adjacent to the liquid inlet in the pipeline path;
and when the second bubble sensor is detected to acquire a liquid inlet state, the peristaltic pump is closed after liquid inlet is continued for a preset time period, and the pipeline path is full of liquid.
As a further improvement of the above technical solution, the starting of the peristaltic pump, passing the pipeline path through which the liquid in the liquid bag flows to the liquid outlet through the peristaltic pump and the pressure sensor, and closing the peristaltic pump after detecting that the pipeline path is full of liquid, further comprises:
when the decrease of the value acquired by a weighing sensor corresponding to the liquid bag in the weighing system is detected, acquiring a weight threshold value and controlling the peristaltic pump to continue rotating; a pipeline path for liquid in the liquid bag to flow to the liquid outlet passes through a peristaltic pump and a pressure sensor;
and when the weight threshold value is detected to be reached by the value acquired by the weighing sensor, the peristaltic pump is closed, and the pipeline path is full of liquid.
The pipeline airtightness detection system comprises a liquid bag, a peristaltic pump, a pressure sensor, a pipeline system and a controller for executing the pipeline airtightness detection method, wherein the liquid bag is connected with the pipeline system; the controller is communicated with the pressure sensor and the peristaltic pump.
The beneficial effects are that: in the method for detecting the air tightness of the pipeline, the liquid with fixed volume is injected into a pipeline panel system, and the peristaltic pump and the pressure sensors arranged in front of and behind the peristaltic pump are arranged in the pipeline panel, so that the injected liquid can flow through the peristaltic pump through the pipeline. The liquid flows through the peristaltic pump, the peristaltic pump pushes the liquid to be pressurized to a preset pressure value, and the air tightness of the pipeline panel system is judged according to data detected by the pressure sensor.
The gas tightness detection is carried out by compressing each path of gas by the movement of liquid, and the gas tightness detection is carried out by fully combining the mutual pushing acting force of the liquid and the gas, so that the gas tightness detection without manual intervention is realized, the aseptic requirement of a pipeline panel system is ensured, and the full-automatic pipeline gas tightness detection effect is realized. Meanwhile, the introduction of the bubble sensor and the weighing sensor ensures the accuracy of the air tightness test.
Drawings
The invention is further illustrated with reference to the following figures and examples.
FIG. 1 is a system diagram of a first embodiment of the present invention;
FIG. 2 is a system diagram of a second embodiment of the present invention;
FIG. 3 is a flow chart of the method for detecting the airtightness of the pipeline according to the present invention.
1. An upper pipeline; 2. a lower pipeline; 3. a peristaltic pump; 4. a control valve; 5. a pressure sensor; 6. a fluid bag; 7. a centrifugal cup; 8. a weighing system; 9. and a bubble sensor.
Detailed Description
The conception, the specific structure, and the technical effects produced by the present invention will be clearly and completely described below in conjunction with the embodiments and the accompanying drawings to fully understand the objects, the features, and the effects of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and other embodiments obtained by those skilled in the art without inventive efforts are within the protection scope of the present invention based on the embodiments of the present invention. In addition, all the connection relations related in the patent do not mean that the components are directly connected, but mean that a better connection structure can be formed by adding or reducing connection auxiliary components according to specific implementation conditions. All technical characteristics in the invention can be interactively combined on the premise of not conflicting with each other.
Referring to fig. 1, a pipeline airtightness detection device comprises a peristaltic pump 3 and a pipeline system, wherein the peristaltic pump 3 is arranged at one end of the pipeline system and is used for urging liquid and gas in the pipeline system, and a plurality of passages are arranged in the pipeline system; furthermore, a plurality of control valves 4 are arranged on the pipeline system, the control valves 4 are used for controlling the communication and the closing of different passages of the pipeline system, the control valves 4 can be arranged at two ends of each pipeline to control each pipeline respectively, and can also be arranged at the connection positions of a plurality of pipelines to control the opening and the closing of the plurality of pipelines together; before carrying out the gas tightness and detecting, need open control valve 4, carry out the feed liquor, close control valve 4 with feed liquor department or play liquid department again after the feed liquor is accomplished, carry out the gas tightness of gas circuit and detect through peristaltic pump 3. Further, the pipeline system is also provided with a pressure sensor 5, and the pressure sensor 5 is arranged between the peristaltic pump 3 and the plurality of passages in the pipeline system and is used for detecting the pressure of the pipeline between the peristaltic pump 3 and the plurality of passages in the pipeline system. Pressure sensor 5 and peristaltic pump 3 cooperate, and peristaltic pump 3 promotes the liquid in the pipeline to lead to the gas in the pipeline to be extruded simultaneously, just produced pressure in the pipeline, alright detect out the pressure in the pipeline through pressure sensor 5 this moment, and then the rethread is predetermine the comparison of parameter value and alright reachs the gas tightness of pipeline. The pipeline in this case may be a single pipeline channel or a combination of multiple pipeline channels. Cooperate with peristaltic pump 3 through pressure measurement system, thereby utilize peristaltic pump 3 to promote liquid in the pipeline and cause the pressure measurement mode of extrusion production pressure to the gas in the pipeline, can realize easy operation, be convenient for go on under sterile environment, can also accurately, measure pressure value or relevant data fast, realize aseptic, the efficient testing process to pipeline gas tightness.
Referring to fig. 2, as an embodiment of the present scheme, the pipeline system includes an upper pipeline 1 and a lower pipeline 2, where the upper pipeline 1 and the lower pipeline 2 are respectively disposed at two sides of a peristaltic pump 3 and are both driven by the peristaltic pump 3; further, the upper pipeline 1 and the lower pipeline 2 are both provided with a pressure sensor 5, and the pressure sensor 5 is communicated with a pipeline system, namely, the pressure sensor 5 is arranged in a pipeline path of the pipeline system. The peristaltic pump 3 is used for urging liquid and gas in a pipeline system, and a plurality of passages are arranged in the pipeline system; furthermore, a plurality of upper pipeline 1 channels and a plurality of lower pipeline 2 channels can also extend from the upper pipeline 1 and the lower pipeline 2. A plurality of control valves 4 are arranged in the upper pipeline 1 and the lower pipeline 2, and the control valves 4 are respectively used for communicating and closing a plurality of channels on the upper pipeline 1 and communicating and closing a plurality of channels on the lower pipeline 2. In addition, the control valve 4 is also arranged on a channel at the joint of the upper pipeline 1 and the peristaltic pump 3 and a channel at the joint of the lower pipeline 2 and the peristaltic pump 3, and is used for controlling the communication between the upper pipeline 1 and the peristaltic pump 3 and the communication between the lower pipeline 2 and the peristaltic pump 3. Specifically, need open the control valve 4 that sets up on the total passageway between peristaltic pump 3 and upper pipeline 1 before carrying out the gas tightness and detect, carry out the feed liquor, upper pipeline 1 and 2 structures of lower pipeline form a complete feed liquor system of going out the liquid, and through a peristaltic pump 3 alright two pipelines of simultaneous control, practiced thrift the cost, guaranteed the efficiency that detects.
As another embodiment of the present invention, the upper pipeline 1 and the lower pipeline 2 are connected to the fluid bag 6 and the centrifuge cup 7, respectively, and the fluid bag 6 may be provided in plural. The pressure sensors 5 comprise a first pressure sensor 5 and a second pressure sensor 5, wherein the first pressure sensor 5 and the second pressure sensor 5 are respectively arranged at two sides of the peristaltic pump 3 and are respectively used for detecting the pressure in the pipeline from the peristaltic pump 3 to the liquid bag 6 and from the peristaltic pump 3 to the centrifugal cup 7. Pressure sensor 5 and peristaltic pump 3 cooperate, and peristaltic pump 3 promotes the liquid in the pipeline to lead to the gas in the pipeline to be extrudeed simultaneously, just produced pressure in the pipeline, alright detect out the pressure in the pipeline through pressure sensor 5 this moment, and then the rethread some predetermine the comparison of parameter value alright obtain the gas tightness of pipeline. When the peristaltic pump 3 rotates clockwise (equivalent to reverse rotation), liquid is pushed from the peristaltic pump 3 to the direction of the liquid bag 6, the pushed liquid extrudes mixed gas due to the fact that the whole pipeline is of a sealing structure, the pressure generated by the extrusion can pass through the first pressure sensor 5, and the first pressure sensor 5 can sense the pressure, so that a parameter compared with a first preset value is obtained, and the air tightness of the upper pipeline 1 can be determined. Similarly, when the peristaltic pump 3 rotates counterclockwise (corresponding to a forward rotation), the liquid is pushed from the peristaltic pump 3 to the centrifugal cup 7, a control valve controls the opening and closing between the lower pipe 2 and the centrifugal cup 7 before the centrifugal cup 7, the control valve is in a closed state at this time, because the whole pipe is in a sealed structure, the pushed liquid can extrude the mixed gas, the pressure generated by the extrusion can pass through the second pressure sensor 5, the second pressure sensor 5 can sense the pressure, so that a parameter which is compared with a second preset value is obtained, and the air tightness of the lower pipe 2 can be determined, wherein the first preset value and the second preset value are pressure values which are set by historical experiments and used for measuring the air tightness of the pipe.
As another embodiment of the scheme, a weighing system 8 is further arranged in the pipeline system, and the weighing system 8 is used for weighing the liquid bag 6 and the centrifuge cup 7. Specifically, the weighing system 8 is disposed at the fluid bag 6, and the initial fluid weight in the fluid bag 6 and the existing fluid weight in the fluid bag 6 are obtained by weighing with the weighing system 8, so as to obtain the fluid weight reduced in the fluid bag 6 within a fixed time. Then, the weight of the liquid in the liquid bag 6 is compared with the weight of the liquid in the preset injection line for a fixed period of time, and it can be determined whether the injected liquid completely covers the entire preset line path. Meanwhile, the weighing system 8 can be arranged at the centrifugal cup 7, and the original weight of the centrifugal cup 7 and the existing weight of the centrifugal cup 7 can be weighed by the weighing system 8, so that the weight of the liquid filled into the centrifugal cup 7 within a fixed time can be obtained. It can then also be determined whether the injected liquid completely covers the entire preset line path by comparing the weight of the liquid injected into the centrifuge cup 7 with the weight of the liquid in the preset injection line for a fixed period of time. The two weighing systems 8 can be arranged into an integral structure with the whole pipeline, and a weighing sensor is arranged at the weighing position for weighing. And a control system is arranged between the weighing system 8 and the pipeline, so that various data weighed by the weighing system 8 can be recorded and calculated by using a manual reading and manual calculation method, the processes of automatic reading, automatic data recording and comparison can be realized through the control system, the final comparison result can be displayed on a display panel connected with the control system, and the complete automatic detection process is realized. The setting of weighing system 8 can be controlled the feed liquor condition of pipeline at the in-process of pipeline feed liquor, and it is longer to avoid the feed liquor process, and extravagant material avoids consuming unnecessary time when the feed liquor, has further improved detection efficiency.
As another embodiment of the present disclosure, in addition to detecting whether the pipeline is full of liquid by weighing, a bubble sensor 9 is further disposed in the pipeline system, and the bubble sensor 9 is configured to detect a liquid flowing state in the pipeline. The bubble sensors 9 are arranged in the passages of the pipelines, one bubble sensor is arranged in a general pipeline structure, and the bubble sensors 9 can be arranged on each channel of one pipeline, so that the detection sensitivity and accuracy can be improved. To setting up the bubble sensor 9 in the pipeline, can observe whether to sense liquid through bubble sensor 9 and flow to judge whether liquid is full of in the pipeline, thereby reachs peristaltic pump 3 and whether stall. Besides recording and calculating the parameters of the bubble sensor 9 by using a manual reading and manual calculation method, the automatic reading, automatic data recording and comparison processes can be realized through a control system, and the final comparison result can be displayed on a display panel connected with the control system, so that the complete automatic detection process is realized. The function that sets up of bubble sensor 9 is similar with weighing system 8, can control the feed liquor condition of pipeline at the in-process of pipeline feed liquor, avoids the feed liquor process longer, and extravagant material avoids consuming unnecessary time when the feed liquor, has further improved detection efficiency.
Referring to fig. 3, as an application of the above-mentioned pipe airtightness detection apparatus, there is also a pipe airtightness detection method including:
opening a control valve 4 corresponding to a liquid inlet connected with a liquid bag 6 and a control valve 4 corresponding to a liquid outlet in a pipeline system to be tested;
starting the peristaltic pump 3, enabling a pipeline path of the liquid in the liquid bag 6 flowing to the liquid outlet to pass through the peristaltic pump 3 and the pressure sensor 5, and closing the peristaltic pump 3 after detecting that the pipeline path is full of liquid; the tubing system comprises the tubing path;
and starting the peristaltic pump 3 after closing all the control valves 4 in the pipeline system, and determining a pipeline airtightness result of the pipeline system according to the rotation direction of the peristaltic pump 3, a preset threshold corresponding to the rotation direction and a pressure parameter in the pipeline path measured by the pressure sensor 5 in the rotation process.
A plurality of upper pipeline 1 channels and a plurality of lower pipeline 2 channels can also extend from the upper pipeline 1 and the lower pipeline 2. The upper pipeline 1 and the lower pipeline 2 are both provided with a plurality of control valves 4, and the control valves 4 are respectively used for communicating and closing a plurality of channels in the upper pipeline 1 and communicating and closing a plurality of channels in the lower pipeline 2. In addition, the control valve 4 is also arranged on a channel at the joint of the upper pipeline 1 and the peristaltic pump 3 and a channel at the joint of the lower pipeline 2 and the peristaltic pump 3, and is used for controlling the communication between the upper pipeline 1 and the peristaltic pump 3 and the communication between the lower pipeline 2 and the peristaltic pump 3.
As an embodiment of the present application, the control valve 4 includes a control valve 4 for controlling the liquid inlet and a control valve 4 for controlling the liquid outlet, the control valve 4 for controlling the liquid inlet is connected to the liquid bag 6 through a pipe intersection, so that the liquid in the liquid bag 6 enters the liquid from the pipe intersection, and the control valve 4 for controlling the liquid outlet is connected to the centrifugal cup 7 through a pipe intersection. Namely, the control valve 4 of the liquid inlet is the control valve 4 of the upper pipeline 1, the control valve 4 of the liquid outlet is the control valve 4 of the lower pipeline 2, the control valve 4 of the upper pipeline 1 is used for controlling the liquid in the liquid bag 6 to flow in the pipeline, and the control valve 4 of the lower pipeline 2 is used for controlling whether the liquid in the pipeline flows to the centrifugal cup 7 or not.
The peristaltic pump 3 is arranged between the upper pipeline 1 and the lower pipeline 2 and is arranged at the communication position of the upper pipeline 1 and the lower pipeline 2. Specifically, need open the control valve 4 that sets up on the main passageway between peristaltic pump 3 and upper pipeline 1 before carrying out the gas tightness and detecting, carry out the feed liquor, close control valve 4 after the feed liquor is accomplished and set peristaltic pump 3 to clockwise rotation (reversal), then detect the data that generate through pressure sensor 5, set peristaltic pump 3 to anticlockwise rotation (corotation) after closing control valve 4, then detect the data that generate through pressure sensor 5.
In one embodiment, the starting of the peristaltic pump 3, the flowing of the liquid in the liquid bag 6 to the liquid outlet via the peristaltic pump 3 and the pressure sensor 5, and the closing of the peristaltic pump 3 after detecting that the liquid in the liquid bag is full comprise:
when detecting that the first bubble sensor 9 collects the liquid inlet state, controlling the peristaltic pump 3 to continue rotating; the first bubble sensor 9 is arranged adjacent to the inlet in the pipe path.
When the liquid inlet state collected by the second bubble sensor 9 is detected, the peristaltic pump 3 is closed after liquid inlet is continued for a preset time period, and the pipeline path is full of liquid; the second bubble sensor 9 is arranged adjacent to the exit opening in the conduit path.
Wherein, the liquid inlet state is a state that liquid flows.
It will be appreciated that a bubble sensor 9 may be employed to determine whether the predetermined line is full of liquid. The bubble sensors 9 are arranged in the passages of the pipelines, one bubble sensor is arranged in a general pipeline structure, and the bubble sensors 9 can be arranged on each channel of one pipeline, so that the detection sensitivity and accuracy can be improved. To setting up the bubble sensor 9 in the pipeline, can observe whether to sense liquid through bubble sensor 9 and flow to judge whether liquid is full of in the pipeline, thereby reachs peristaltic pump 3 and whether stall.
Besides recording and calculating the parameters of the bubble sensor 9 by using a manual reading and manual calculation method, the automatic reading, automatic data recording and comparison processes can be realized through a control system, and the final comparison result can be displayed on a display panel connected with the control system, so that the complete automatic detection process is realized.
Specifically, bubble sensor 9 includes first bubble sensor and second bubble sensor, the inlet port department on pipeline route is provided with first bubble sensor, when first bubble sensor sensed liquid flow, peristaltic pump 3 continued to rotate the feed liquor. And a second bubble sensor is arranged at the liquid outlet of the pipeline path, when the second bubble sensor senses that the liquid in the pipeline path flows, the liquid is full, the peristaltic pump 3 continues to rotate for a preset time period and then stops rotating, wherein the preset time period is the minimum time period for the liquid in the preset pipeline path to reach the centrifugal cup 7.
In one embodiment, the starting the peristaltic pump 3, the tube path of the liquid in the liquid bag 6 to the liquid outlet passing through the peristaltic pump 3 and the pressure sensor 5, and the closing the peristaltic pump 3 after detecting that the tube path is full of liquid, further comprises:
when the decrease of the value acquired by the weighing sensor corresponding to the liquid bag 6 in the weighing system 8 is detected, acquiring a weight threshold value and controlling the peristaltic pump 3 to continue rotating; the tubing path that flows the liquid in the bag of liquid 6 to the liquid outlet passes through peristaltic pump 3 and pressure sensor 5.
When the value acquired by the weighing sensor reaches the weight threshold value, the peristaltic pump 3 is closed, and the pipeline path is full of liquid.
It will be appreciated that the weighing system 8 is used to determine whether the predetermined line is full of liquid. The weighing system 8 is arranged at the fluid bag 6, and the initial weight of the fluid in the fluid bag 6 and the existing weight of the fluid in the fluid bag 6 are obtained by weighing with the weighing system 8, so as to obtain the weight of the fluid reduced in the fluid bag 6 within a fixed time. Then, the weight of the liquid in the liquid bag 6 is compared with the weight of the liquid in the preset injection pipeline in a fixed time period, or the weight of the liquid is compared with a weight threshold value, so that whether the injected liquid completely covers the whole preset pipeline path can be determined, wherein the weight threshold value is a historical statistical weight value of the liquid required for filling the whole pipeline path. Meanwhile, the weighing system 8 can be arranged at the centrifugal cup 7, and the original weight of the centrifugal cup 7 and the existing weight of the centrifugal cup 7 are weighed by the weighing system 8, so that the weight of the liquid filled into the centrifugal cup 7 in a fixed time is obtained. Then, by comparing the weight of the liquid filled into the centrifugal cup 7 with the weight of the liquid in the preset filling pipeline in a fixed time period, or comparing the weight of the liquid over-filled into the centrifugal cup 7 with the weight threshold, it can also be determined whether the filled liquid completely covers the whole preset pipeline path, wherein the weight threshold can also be a weight value weighed by historical statistics after the centrifugal cup 7 is filled with the whole pipeline path and liquid appears. The two weighing systems 8 can be arranged into an integral structure with the whole pipeline, and a weighing sensor is arranged at the weighing position for weighing. And a control system is arranged between the weighing system 8 and the pipeline, so that various data weighed by the weighing system 8 can be recorded and calculated by using a manual reading and manual calculation method, the processes of automatic reading, automatic data recording and comparison can be realized through the control system, the final comparison result can be displayed on a display panel connected with the control system, and the complete automatic detection process is realized.
Specifically, the inlet department of pipeline is provided with weighing system 8, weighs through weighing system 8 and obtains the liquid weight that reduces in the liquid bag 6, and the liquid weight that predetermines the injection pipeline in the time quantum of reducing is the same with the liquid weight of predetermineeing the injection pipeline and confirms that the liquid of injecting completely covers whole predetermined pipeline route.
Or a weighing system 8 is arranged at the liquid outlet of the pipeline, the weight of the liquid injected into the centrifugal cup 7 is obtained by weighing through the weighing system 8, and when the weight of the liquid injected into the centrifugal cup 7 is the same as the weight of the liquid in the preset injection pipeline within a fixed time period, the injected liquid is determined to completely cover the whole preset pipeline path.
In one embodiment, the step of starting the peristaltic pump 3 after closing all the control valves 4 in the pipeline system, and determining the pipeline airtightness result of the pipeline system according to the rotation direction of the peristaltic pump 3, the preset threshold corresponding to the rotation direction, and the pressure parameter in the pipeline path measured by the pressure sensor 5 during the rotation process includes:
after the rotation direction of the peristaltic pump 3 is set to be the clockwise direction, starting the peristaltic pump 3 to rotate in the clockwise direction, and acquiring a first threshold value corresponding to the clockwise direction; the preset threshold includes the first threshold and a second threshold.
Understandably, the first threshold is a preset pressure threshold for measuring whether the upper pipeline 1 is closed or not in historical statistics, and the second threshold is a preset pressure threshold for measuring whether the lower pipeline 2 is closed or not in historical statistics.
Determining an upper pipeline 1 airtightness result corresponding to an upper pipeline 1 in the pipeline system according to the first threshold and a first limit pressure value measured by the first pressure sensor 5; the pressure parameter comprises the first limit pressure value and a second limit pressure value; the pressure sensors 5 include the first pressure sensor 5 and the second pressure sensor 5.
Understandably, the first limit pressure value is a pressure value of a limit measured by the upper pipeline 1 in the rotation process of the current peristaltic pump 3, or an in-pipe pressure value of the upper pipeline 1 detected after the current peristaltic pump 3 rotates for a threshold duration, the second limit pressure value is a pressure value of a limit measured by the lower pipeline 2 in the rotation process of the current peristaltic pump 3, or an in-pipe pressure value of the lower pipeline 2 detected after the current peristaltic pump 3 rotates for a threshold duration, and the threshold duration is a theoretical duration for measuring that the air pressure rises to reach the limit air pressure under the condition of intact air tightness.
And stopping the rotation of the peristaltic pump 3, changing the rotation direction of the peristaltic pump 3 into the anticlockwise direction, starting the peristaltic pump 3 to rotate in the anticlockwise direction, and acquiring the second threshold corresponding to the anticlockwise direction.
And determining an air tightness result of the lower pipeline 2 corresponding to the lower pipeline 2 in the pipeline system according to the second threshold and the second extreme pressure limiting value measured by the second pressure sensor 5.
And determining the pipeline airtightness result according to the upper pipeline 1 airtightness result and the lower pipeline 2 airtightness result.
In an embodiment, said determining an upper pipeline 1 airtightness result corresponding to an upper pipeline 1 in said pipeline system, based on said first threshold value and a first limit pressure value measured by a first pressure sensor 5, comprises:
and performing limit value identification on all pressure values measured by the first pressure sensor 5 in the rotation process of the peristaltic pump 3, and identifying the first limit pressure value.
Understandably, the process of identifying the limit value may be a process of predicting the limit pressure value when the measured pressure value is not increasing or is maintained in a fixed fluctuation range, or may be a process of predicting the limit pressure value by performing limit prediction of curve distribution on all the measured pressure values through a limit identification model, wherein the limit identification model performs deep learning for historical curve samples, learns limit characteristics of different curves, namely, curve slope change characteristics reaching the limit value, and thus can predict a neural network model of the corresponding limit value.
Comparing the first limit pressure value to the first threshold value.
And when the first limit pressure value is smaller than the first threshold value, determining that the air tightness result of the upper pipeline 1 is unqualified.
And when the first limit pressure value is greater than or equal to the first threshold value, determining that the air tightness result of the upper pipeline 1 is qualified.
In an embodiment, determining the lower pipeline 2 airtightness result corresponding to the lower pipeline 2 in the pipeline system according to the second threshold and the second limit pressure value measured by the second pressure sensor comprises:
performing limit value identification on all pressure values measured by the second pressure sensor in the rotation process of the peristaltic pump 3, and identifying a second limit value;
comparing the second limit voltage value with the second threshold value;
when the second limit pressure value is smaller than the second threshold value, determining that the air tightness result of the lower pipeline 2 is unqualified;
and when the second limit pressure value is greater than or equal to the second threshold value, determining that the air tightness result of the lower pipeline 2 is qualified.
For example, the preset pressure value in the pipeline is determined by the parameters of the peristaltic pump 3, the pipeline and other products
. The peristaltic pump 3 is set to rotate clockwise (reverse rotation) and then the main channel control valve 4 on the lower line 2 and the control valve 4 of the upper line 1 at the inlet are closed. The liquid in the pipe system will rotate at a flow rate of 20mL/min for a time period of X1. Then whether the pressure in the outlet pipe reaches a first preset pressure value is measured by the first pressure sensor in an induction way
If the air tightness of the upper pipeline 1 can be achieved, the air tightness of the upper pipeline 1 is displayed to be qualified on the display panel, and if the air tightness of the upper pipeline 1 cannot be achieved, the air tightness is displayed to be unqualified.
Firstly, the preset pressure value in the pipeline is determined to be
. Is provided withThe peristaltic pump 3 rotates counterclockwise (rotates forward), and then the main channel control valve 4 on the upper pipeline 1 and the control valve 4 on the lower pipeline 2 at the liquid outlet are closed. The liquid in the pipe system will rotate at a flow rate of 20mL/min for a time period of X2. Then whether the pressure in the outlet pipe reaches a first preset pressure value is measured by sensing of the first pressure sensor
If the air tightness of the upper pipeline 1 can be achieved, the air tightness of the upper pipeline 1 is displayed to be qualified on the display panel, and if the air tightness of the upper pipeline 1 cannot be achieved, the air tightness is displayed to be unqualified.
In an embodiment, said determining an upper pipeline 1 airtightness result corresponding to an upper pipeline 1 in the pipeline system based on the first threshold value and a first limit pressure value measured by the first pressure sensor further includes:
acquiring a threshold duration corresponding to the first threshold;
measuring the time length for the first limit pressure value to reach the first threshold value through a first pressure sensor, and recording the time length as the measuring time length;
when the measuring time length is less than the threshold time length, determining that the airtight result of the upper pipeline 1 is qualified;
and when the measuring time is longer than or equal to the threshold time, determining that the airtight result of the upper pipeline 1 is unqualified.
In an embodiment, determining the lower pipeline 2 airtightness result corresponding to the lower pipeline 2 in the pipeline system according to the second threshold and the second limit value measured by the second pressure sensor further includes:
acquiring a threshold duration corresponding to the second threshold;
measuring the time length of the second limit pressure value reaching the second threshold value through a second pressure sensor, and recording the time length as the measurement time length;
when the measuring time length is less than the threshold value time length, determining that the airtight result of the lower pipeline 2 is qualified;
and when the measuring time length is greater than or equal to the threshold time length, determining that the airtight result of the lower pipeline 2 is unqualified.
For example, the preset pressure value in the pipeline is determined by the parameters of the peristaltic pump 3, the pipeline and other products
And setting the peristaltic pump 3 to rotate clockwise (reverse) for 20S, and then closing the main channel control valve 4 on the lower pipeline 2 and the control valve 4 of the upper pipeline 1 at the liquid inlet. The liquid in the pipeline system can reach a first preset pressure value by sensing and measuring the pressure in the outlet pipe through the first pressure sensor at the flow rate of 20mL/min
The duration used is X3, if X3>And 20s, judging that the air tightness of the upper pipeline 1 is unqualified, and automatically displaying on a display panel: "there is a risk of leakage in the upper end of the tube of the peristaltic pump 3" if X3<20s, judging that the air tightness is qualified;
and (3) setting the peristaltic pump 3 to rotate anticlockwise (rotate forwards), wherein the threshold duration is 20S, and then closing the main channel control valve 4 on the upper pipeline 1 and the control valve 4 of the lower pipeline 2 at the liquid outlet. The liquid in the pipeline system can reach a first preset pressure value through the sensing and measurement of the pressure in the outlet pipe by the first pressure sensor at the flow rate of 20mL/min
The duration used is X4, if X4>And 20s, judging that the air tightness of the upper pipeline 1 is unqualified, and automatically displaying on a display panel: "there is a risk of leakage in the upper end of the tube of the peristaltic pump 3" if X4<And 20s, judging that the air tightness is qualified.
And determining that the air tightness of the pipeline panel system is qualified under the condition that the air tightness of the upper pipeline 1 and the lower pipeline 2 are qualified.
Preferably, a waste discharge pipeline is preset in the pipeline system, when waste liquid is discharged through a preset pipeline path, the waste liquid discharged by the master control valve 4 of the upper pipeline 1 and the lower pipeline 2 is measured to be 100mL, and the pump flow is measured to be 200mL/min. Therefore, the air tightness detection of the pipeline panel system can be automatically completed, and the aseptic requirement can be met.
The invention also provides a pipeline airtightness detection system, as shown in fig. 2, the pipeline airtightness detection system comprises a liquid bag 6, a peristaltic pump 3, a pressure sensor 5, a pipeline system, and a controller for executing the above pipeline airtightness detection method, wherein the liquid bag 6 is connected with the pipeline system; the controller is communicated with the pressure sensor 5 and the peristaltic pump 3, and specific limitations on the controller can be referred to the above limitations on the pipeline airtightness detection method and the pipeline airtightness detection method, which are not described herein again, and all or part of the modules in the controller can be realized by software, hardware and a combination thereof. The modules can be embedded in a hardware form or independent from a processor in the computer device, and can also be stored in a memory in the computer device in a software form, so that the processor can call and execute operations corresponding to the modules.
It will be understood by those skilled in the art that all or part of the processes of the methods of the embodiments described above may be implemented by hardware instructions of a computer program, which may be stored in a non-volatile computer-readable storage medium, and when executed, may include the processes of the embodiments of the methods described above. Any reference to memory, storage, database, or other medium used in the embodiments provided herein may include non-volatile and/or volatile memory, among others. Non-volatile memory can include read-only memory (ROM), programmable ROM (PROM), electrically Programmable ROM (EPROM), electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double Data Rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous Link DRAM (SLDRAM), rambus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).
It should be clear to those skilled in the art that, for convenience and simplicity of description, the foregoing division of the functional units and modules is only used for illustration, and in practical applications, the above function distribution may be performed by different functional units and modules as needed, that is, the internal structure of the apparatus may be divided into different functional units or modules to perform all or part of the above described functions.
While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (7)
1. A pipeline air tightness detection method is characterized by comprising the following steps: the method comprises the following steps:
opening a control valve corresponding to a liquid inlet connected with a liquid bag and a control valve corresponding to a liquid outlet in a pipeline system to be tested;
starting a peristaltic pump, enabling liquid in the liquid bag to flow to a pipeline path of the liquid outlet to pass through the peristaltic pump and a pressure sensor, and closing the peristaltic pump after detecting that the pipeline path is full of liquid; the tubing system comprises the tubing path;
and starting the peristaltic pump after closing all control valves in the pipeline system, and determining a pipeline airtightness result of the pipeline system according to the rotation direction of the peristaltic pump, a preset threshold corresponding to the rotation direction and a pressure parameter in the pipeline path measured by a pressure sensor in the rotation process.
2. The method for detecting the airtightness of the pipeline according to claim 1, wherein the step of starting the peristaltic pump after closing all the control valves in the pipeline system and determining the airtightness result of the pipeline system according to the rotation direction of the peristaltic pump, a preset threshold corresponding to the rotation direction and a pressure parameter in the pipeline path measured by a pressure sensor during the rotation process comprises:
after the rotation direction of the peristaltic pump is set to be the clockwise direction, starting the peristaltic pump to rotate in the clockwise direction, and acquiring a first threshold value corresponding to the clockwise direction; the preset threshold comprises the first threshold and a second threshold;
the pipeline system comprises an upper pipeline and a lower pipeline, wherein the upper pipeline and the lower pipeline are respectively arranged at two sides of the peristaltic pump and are driven by the peristaltic pump;
determining an upper pipeline air-tight result corresponding to an upper pipeline in the pipeline system according to the first threshold and a first limit pressure value measured by a first pressure sensor; the pressure parameters comprise the first limit pressure value and a second limit pressure value; the pressure sensors include the first pressure sensor and a second pressure sensor;
stopping the rotation of the peristaltic pump, changing the rotation direction of the peristaltic pump into the anticlockwise direction, starting the peristaltic pump to rotate in the anticlockwise direction, and acquiring the second threshold corresponding to the anticlockwise direction;
determining a lower pipeline airtight result corresponding to a lower pipeline in the pipeline system according to the second threshold and a second limit pressure value measured by the second pressure sensor;
and determining the pipeline air tightness result according to the upper pipeline air tightness result and the lower pipeline air tightness result.
3. The method for detecting air tightness of a pipeline according to claim 2, wherein the determining an upper pipeline air tightness result corresponding to an upper pipeline in the pipeline system according to the first threshold value and the first limit pressure value measured by the first pressure sensor comprises:
performing limit value identification on all pressure values measured by the first pressure sensor in the rotation process of the peristaltic pump, and identifying the first limit pressure value;
comparing the first limit pressure value to the first threshold value;
when the first limit pressure value is smaller than the first threshold value, determining that the upper pipeline airtight result is unqualified;
and when the first limit pressure value is larger than or equal to the first threshold value, determining that the upper pipeline airtight result is qualified.
4. The method for detecting the airtightness of the pipeline according to claim 2, wherein the determining, according to the second threshold value and the second limit pressure value measured by the second pressure sensor, a lower pipeline airtightness result corresponding to a lower pipeline in the pipeline system comprises:
acquiring a threshold duration corresponding to the second threshold;
measuring the time length for the second limit pressure value to reach the second threshold value through a second pressure sensor, and recording the time length as the measuring time length;
when the measuring duration is less than the threshold duration, determining that the lower pipeline air-tight result is qualified;
and when the measurement duration is greater than or equal to the threshold duration, determining that the lower pipeline air-tight result is unqualified.
5. The method for detecting the airtightness of the pipeline according to claim 1, wherein the starting of the peristaltic pump, the flowing of the liquid in the liquid bag to the pipeline path of the liquid outlet via the peristaltic pump and the pressure sensor, and the closing of the peristaltic pump after detecting that the pipeline path is full of liquid comprises:
when detecting that the first bubble sensor acquires a liquid inlet state, controlling the peristaltic pump to continue rotating; the first bubble sensor is arranged adjacent to the liquid inlet in the pipeline path;
when the second bubble sensor is detected to acquire a liquid inlet state, the peristaltic pump is closed after liquid inlet is continued for a preset time period, and the pipeline path is indicated to be full of liquid; the second bubble sensor is disposed adjacent to the liquid outlet in the conduit path.
6. The method for detecting the airtightness of the tube according to claim 1, wherein the starting of the peristaltic pump, the flowing of the liquid in the liquid bag to the tube path of the liquid outlet via the peristaltic pump and the pressure sensor, and the closing of the peristaltic pump after detecting that the tube path is full of the liquid, further comprises:
when the decrease of the value acquired by a weighing sensor corresponding to the liquid bag in the weighing system is detected, acquiring a weight threshold value and controlling the peristaltic pump to continue rotating; a pipeline path for the liquid in the liquid bag to flow to the liquid outlet passes through a peristaltic pump and a pressure sensor;
and when the weight threshold value is detected to be reached by the value acquired by the weighing sensor, the peristaltic pump is closed, and the pipeline path is full of liquid.
7. A tube airtightness detection system comprising a liquid bag, a peristaltic pump, a pressure sensor and a tube system, and a controller for executing the tube airtightness detection method according to any one of claims 1 to 6, the liquid bag being connected to the tube system; the controller is in communication with the pressure sensor and the peristaltic pump.
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| CN118168731A (en) * | 2024-05-13 | 2024-06-11 | 上海韬睿生物科技有限公司 | Method, system and device for detecting tightness after pipeline installation |
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