CN114984463A

CN114984463A - Experimental mouse radiotherapy positioning and fixing device and operation method thereof

Info

Publication number: CN114984463A
Application number: CN202210554283.9A
Authority: CN
Inventors: 王夺; 肖泽宇; 罗良平; 史长征
Original assignee: Jinan University
Current assignee: Jinan University
Priority date: 2022-05-20
Filing date: 2022-05-20
Publication date: 2022-09-02

Abstract

The invention discloses a positioning and fixing device for radiotherapy of an experimental mouse, which comprises an operation table, wherein fixing pieces are arranged on the operation table at positions corresponding to four limbs of the mouse, the fixing pieces are movably connected to the operation table in an adjustable mode, a hood is arranged on the operation table at a position corresponding to the head of the mouse, the hood is movably connected to the operation table in an adjustable mode, the hood is funnel-shaped, and the size of the hood is matched with the mouth and nose of the mouse. The invention can provide good limit for the limbs and the head of the mouse, thereby facilitating the operation of radiotherapy experiments and improving the success rate of the experiments.

Description

Experimental mouse radiotherapy positioning and fixing device and operation method thereof

Technical Field

The invention relates to the field of biomedical scientific research experiments, in particular to a radiotherapy positioning and fixing device for an experimental mouse and an operation method thereof.

Background

At present, a mouse is an experimental animal commonly used in medical research, when a radiotherapy test is carried out on an experimental mouse, the traditional rubber band fixing device is poor in fixing effect and not strong in applicability, and a worker can be bitten by the loosened mouse.

Disclosure of Invention

Based on the above problems, the present invention aims to provide a positioning and fixing device for radiotherapy of an experimental mouse, and the present invention adopts the following technical scheme:

the invention provides a positioning and fixing device for radiotherapy of an experimental mouse, which comprises an operation table, wherein fixing pieces are arranged on the operation table at positions corresponding to four limbs of the mouse, the fixing pieces are movably connected to the operation table in an adjustable mode, a hood is arranged on the operation table at a position corresponding to the head of the mouse, the hood is movably connected to the operation table in an adjustable mode, the hood is funnel-shaped, and the size of the hood is matched with the mouth and nose of the mouse.

Preferably, the mounting is including the fixed frame that is mouth style of calligraphy structure, gliding clamp splice about being provided with in the fixed frame, the top of clamp splice is provided with first hand and twists the bolt, first hand is twisted bolt threaded connection and is in on the fixed frame, just first hand is twisted the lower extreme of bolt and is rotated and be connected on the clamp splice.

Preferably, be provided with first slide hole of leading in the position corresponding with mouse four limbs on the operation panel, first slide hole of leading arranges along mouse four limbs direction, the bottom of fixed frame is fixed with first screw rod, first screw rod runs through behind the first slide hole of leading with first fastening nut threaded connection.

Preferably, a second sliding guide hole is formed in the position, corresponding to the head of the mouse, of the operating platform, the second sliding guide hole is arranged along the direction of the head of the mouse, a head cover seat is arranged at the bottom of the head cover, a second screw rod is arranged at the bottom of the head cover seat, and the second screw rod penetrates through the second sliding guide hole and then is in threaded connection with a second fastening nut.

Preferably, a plurality of breathing holes are arranged on the outer wall of the hood.

Preferably, all be provided with spacing clamp group in the position of mouse health both sides on the operation panel, spacing clamp group includes the base, the interval arrangement has a plurality of guide posts in the middle of the base, the guide post slip joint in the base, the front end of guide post is provided with the stationary dog, the stationary dog is the arc, guide post rear end threaded connection has the third screw rod, the rear end of third screw rod is provided with the knob, the knob rotates to be connected in the base.

Preferably, a magic tape is arranged at the tail of the mouse on the operating platform.

The invention provides an operation method of a positioning and fixing device for radiotherapy of an experimental mouse, which comprises the following steps; placing a mouse on an operation table, then penetrating four limbs of the mouse through a fixed frame, rotating a first hand-screwed bolt to drive a clamping block to clamp, adjusting the position of the fixed frame along a first slide guiding hole to enable the four limbs of the mouse to be in an extending state, and then rotating a first fastening nut to fix the position of the fixed frame; the hood is slid along the second slide guiding hole to be covered at the mouth and nose position of the mouse, and the hood is fixed through a second fastening nut; and finally, fixing the mouse tail by the magic tape.

Compared with the prior art, the invention has the beneficial technical effects that:

the invention can provide good limit for the limbs and the head of the mouse, thereby facilitating the operation of radiotherapy experiments and improving the success rate of the experiments.

Drawings

The invention is further illustrated in the following description with reference to the drawings.

FIG. 1 is a schematic top view of a positioning and fixing device for radiotherapy of an experimental mouse according to the present invention;

FIG. 2 is a schematic front view of a fixing member according to an embodiment of the present invention;

FIG. 3 is a front view of a hood in accordance with an embodiment of the present invention;

FIG. 4 is a schematic top view of a spacing clip set according to an embodiment of the present invention

Fig. 5 is a schematic front view of a spacing clip set according to an embodiment of the invention.

Description of reference numerals: 1. an operation table; 101. a first slide guiding hole; 102. a second slide guide hole; 2. a fixing member; 201. a fixing frame; 202. a clamping block; 203. screwing the bolt by a first hand; 204. a first screw; 205. a first fastening nut; 3. a head cover; 301. a head cover base; 302. a second screw; 303. a second fastening nut; 304. a breathing hole; 4. a limiting clamp group; 401. a base; 402. a guide post; 403. a fixed jaw; 404. a third screw; 405. a knob; 5. magic tape.

Detailed Description

In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more clearly apparent, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.

It should be noted that the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise. The meaning of "a number" is one or more unless specifically limited otherwise.

In the description of the present invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", and the like indicate orientations or positional relationships based on orientations or positional relationships shown in the drawings, which are merely for convenience of description and simplification of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and operate, and thus, should not be construed as limiting the present invention.

As shown in fig. 1, disclose an experimental mice radiotherapy location fixing device in this embodiment, including operation panel 1, the structure of operation panel 1 includes mesa and the supporting leg of mesa below, is provided with mounting 2 in the position corresponding with mouse four limbs on operation panel 1, and four mountings 2 can be fixed the four limbs of mouse respectively, are provided with hood 3 in the position corresponding with mouse head on operation panel 1, and hood 3 is hourglass hopper-shaped, and the size and the oronasal looks adaptation of mouse.

As shown in fig. 2, the fixing member 2 includes a fixing frame 201 having a square structure, a clamping block 202 which slides up and down is provided in the fixing frame 201, a first hand bolt 203 is provided above the clamping block 202, the first hand bolt 203 is screwed to the fixing frame 201, a lower end of the first hand bolt 203 is rotatably connected to the clamping block 202, and the clamping block 202 can be driven to move up and down by rotating the first hand bolt 203, thereby clamping and fixing four limbs of the mouse.

The fixing part 2 is movably connected on the operating platform 1 in an adjustable way, so that the mouse fixing device can adapt to mice with different body sizes. As shown in fig. 1 and 2, in this embodiment, a first slide guiding hole 101 is provided on the operating platform 1 at a position corresponding to a limb of the mouse, the first slide guiding hole 101 is arranged along the limb of the mouse, a first screw 204 is fixed at the bottom of the fixing frame 201, and the first screw 204 penetrates through the first slide guiding hole 101 and then is in threaded connection with a first fastening nut 205. The fixing frame 201 can move along the first sliding guide hole 101 to adjust the position, and after the position adjustment is completed, the fixing frame 2 can be fixed by screwing the first fastening nut 205.

The hood 3 is movably connected on the operating platform 1 in an adjustable way, so that the mouse-shaped mouse-shaping device can adapt to mice with different body sizes. As shown in fig. 1 and 3, in this embodiment, a second slide guiding hole 102 is provided on the console 1 at a position corresponding to the head of the mouse, the second slide guiding hole 102 is arranged along the direction of the head of the mouse, a hood base 301 is provided at the bottom of the hood 3, a second screw 302 is provided at the bottom of the hood base 301, and the second screw 302 is threaded with a second fastening nut 303 after penetrating through the second slide guiding hole 102. The hood 3 can move along the second sliding guide hole 102 to adjust the position, and after the position adjustment is finished, the hood seat 301 can be fixed by screwing the second fastening nut 303.

In this embodiment, in order to facilitate the breathing of the mouse, a plurality of breathing holes 303 are provided on the outer wall of the hood 3, and both ends of the hood 3 are open structures.

In order to prevent the body of the mouse from twisting, in the present embodiment, the operation table 1 is provided with the position limiting clamp groups 4 at both sides of the body of the mouse. As shown in fig. 4 and 5, the spacing clip group 4 includes a base 401, a plurality of guide posts 402 are arranged at intervals in the base 401, the guide posts 402 are slidably clamped in the base 401, a fixing claw 403 is arranged at the front end of the guide posts 402, the fixing claw 403 is arc-shaped, a threaded hole is arranged at the rear end of the guide posts 402, a third screw rod 404 is connected to the threaded hole in a threaded manner, a knob 405 is arranged at the rear end of the third screw rod 404, and the knob 405 is rotatably connected to the base 401. The guide post 402 can be driven to move back and forth by rotating the knob 405, so that the fixed claws 403 can limit the body of the mouse, and each fixed claw 403 can be independently operated.

In this embodiment, the position at mouse tail is provided with magic subsides 5 on operation panel 1, fixes the mouse tail through magic subsides 5. Magic subsides 5 include that the matte is pasted and is pasted with the hook face, and in this embodiment, the matte is pasted and is fixed on operation panel 1, and the area that the matte was pasted is great. The hook face paste can be cut into long strips to fix different positions of the rat tail.

The embodiment also discloses an operation method of the experimental mouse radiotherapy positioning and fixing device, which comprises the following steps; placing a mouse on the operating platform 1, then enabling four limbs of the mouse to penetrate through the fixing frame 201, rotating the first hand-screwed bolt 203 to drive the clamping block 202 to clamp tightly, adjusting the position of the fixing frame 201 along the first sliding guide hole 101 to enable the four limbs of the mouse to be in an extending state, and then rotating the first fastening nut 205 to fix the position of the fixing frame 201; the hood 3 is slid along the second slide guiding hole 102 to be covered at the mouth and nose position of the mouse, and the hood 3 is fixed through a second fastening nut 303; and finally, fixing the mouse tail by the magic tape 5.

The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solutions of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are within the scope of the present invention defined by the claims.

Claims

1. The utility model provides an experimental mice radiotherapy location fixing device which characterized in that: including operation panel (1), be provided with mounting (2) in the position corresponding with mouse four limbs on operation panel (1), swing joint with adjustable mounting (2) is in on operation panel (1), be provided with hood (3) in the position corresponding with mouse head on operation panel (1), swing joint with adjustable hood (3) is in on operation panel (1), hood (3) are hourglass hopper-shaped, and the mouth nose looks adaptation of size and mouse.

2. The experimental mouse radiotherapy positioning fixture of claim 1, wherein: the fixing part (2) is including fixed frame (201) that is mouth style of calligraphy structure, gliding clamp splice (202) from top to bottom is provided with in fixed frame (201), the top of clamp splice (202) is provided with first hand and twists bolt (203), first hand is twisted bolt (203) threaded connection and is in on fixed frame (201), just the lower extreme of first hand is twisted bolt (203) is rotated and is connected on clamp splice (202).

3. The positioning and fixing device for radiotherapy of laboratory mice according to claim 2, wherein: be provided with first slide hole (101) of leading in the position corresponding with mouse four limbs on operation panel (1), first slide hole (101) of leading are arranged along mouse four limbs direction, the bottom of fixed frame (201) is fixed with first screw rod (204), first screw rod (204) run through behind first slide hole (101) and first fastening nut (205) threaded connection.

4. The experimental mouse radiotherapy positioning fixture of claim 1, wherein: the mouse hood is characterized in that a second guide sliding hole (102) is formed in the position, corresponding to the head of a mouse, of the operating platform (1), the second guide sliding hole (102) is arranged along the direction of the head of the mouse, a hood seat (301) is arranged at the bottom of the hood (3), a second screw rod (302) is arranged at the bottom of the hood seat (301), and the second screw rod (302) penetrates through the second guide sliding hole (102) and then is in threaded connection with a second fastening nut (303).

5. The experimental mouse radiotherapy positioning fixture of claim 4, wherein: the outer wall of the hood (3) is provided with a plurality of breathing holes (303).

6. The experimental mouse radiotherapy positioning fixture of claim 1, wherein: the utility model discloses a mouse, including operation panel (1), spacing clamp group (4) are all provided with in the position of mouse health both sides on operation panel (1), spacing clamp group (4) include base (401), a plurality of guide posts (402) have been arranged at the interval in base (401), guide post (402) slip joint is in base (401), the front end of guide post (402) is provided with stationary dog (403), stationary dog (403) are the arc, guide post (402) rear end threaded connection has third screw rod (404), the rear end of third screw rod (404) is provided with knob (405), knob (405) rotate to be connected in base (401).

7. The positioning and fixing device for radiotherapy of laboratory mice according to claim 1, wherein: and a magic tape (5) is arranged at the tail of the mouse on the operating platform (1).

8. An operation method of a positioning and fixing device for radiotherapy of an experimental mouse is characterized by comprising the following steps; placing a mouse on an operation table (1), then enabling four limbs of the mouse to penetrate through a fixing frame (201), rotating a first hand-screwed bolt (203) to drive a clamping block (202) to clamp, adjusting the position of the fixing frame (201) along a first guide sliding hole (101) to enable the four limbs of the mouse to be in an extending state, and then rotating a first fastening nut (205) to fix the position of the fixing frame (201); the hood (3) is slid along the second slide guiding hole (102) to be covered at the mouth and nose position of the mouse, and the hood (3) is fixed through a second fastening nut (303); and finally, fixing the mouse tail by the magic tape (5).