CN114983675A - Medical composite imbibition dressing and preparation method thereof - Google Patents
Medical composite imbibition dressing and preparation method thereof Download PDFInfo
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- CN114983675A CN114983675A CN202210477664.1A CN202210477664A CN114983675A CN 114983675 A CN114983675 A CN 114983675A CN 202210477664 A CN202210477664 A CN 202210477664A CN 114983675 A CN114983675 A CN 114983675A
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- medical
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- polyelectrolyte
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- 239000002131 composite material Substances 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 238000005213 imbibition Methods 0.000 title claims description 17
- 229920000867 polyelectrolyte Polymers 0.000 claims abstract description 124
- 239000007788 liquid Substances 0.000 claims abstract description 46
- 239000011148 porous material Substances 0.000 claims abstract description 38
- 239000000243 solution Substances 0.000 claims description 130
- 229920003169 water-soluble polymer Polymers 0.000 claims description 53
- 238000011049 filling Methods 0.000 claims description 38
- 239000011259 mixed solution Substances 0.000 claims description 27
- 229920001661 Chitosan Polymers 0.000 claims description 25
- 125000000129 anionic group Chemical group 0.000 claims description 25
- 125000002091 cationic group Chemical group 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 19
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 15
- 239000002250 absorbent Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 13
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 12
- 229920002125 Sokalan® Polymers 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 230000002745 absorbent Effects 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 8
- -1 polyvinylamine Polymers 0.000 claims description 8
- 238000007790 scraping Methods 0.000 claims description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
- 229960001631 carbomer Drugs 0.000 claims description 7
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 229920002635 polyurethane Polymers 0.000 claims description 6
- 239000004814 polyurethane Substances 0.000 claims description 6
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 239000005714 Chitosan hydrochloride Substances 0.000 claims description 5
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 claims description 5
- 235000012209 glucono delta-lactone Nutrition 0.000 claims description 5
- 229960003681 gluconolactone Drugs 0.000 claims description 5
- 239000001630 malic acid Substances 0.000 claims description 5
- 235000011090 malic acid Nutrition 0.000 claims description 5
- 239000004584 polyacrylic acid Substances 0.000 claims description 5
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- 239000000515 collagen sponge Substances 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 239000003002 pH adjusting agent Substances 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002101 Chitin Polymers 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 3
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims description 3
- 229920002873 Polyethylenimine Polymers 0.000 claims description 3
- 108010039918 Polylysine Proteins 0.000 claims description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 235000001014 amino acid Nutrition 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 3
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- 238000003618 dip coating Methods 0.000 claims description 3
- 150000002327 glycerophospholipids Chemical class 0.000 claims description 3
- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 3
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- 235000011007 phosphoric acid Nutrition 0.000 claims description 3
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 3
- 229920000172 poly(styrenesulfonic acid) Polymers 0.000 claims description 3
- 229920002401 polyacrylamide Polymers 0.000 claims description 3
- 229920000656 polylysine Polymers 0.000 claims description 3
- 229940005642 polystyrene sulfonic acid Drugs 0.000 claims description 3
- 229920002717 polyvinylpyridine Polymers 0.000 claims description 3
- 235000017550 sodium carbonate Nutrition 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 3
- 238000004528 spin coating Methods 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 229940032147 starch Drugs 0.000 claims description 3
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- 229920002554 vinyl polymer Polymers 0.000 claims description 3
- 239000007983 Tris buffer Substances 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims 1
- 235000011042 metatartaric acid Nutrition 0.000 claims 1
- 239000001369 metatartaric acid Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 description 40
- 239000000499 gel Substances 0.000 description 30
- 238000003756 stirring Methods 0.000 description 13
- 238000010521 absorption reaction Methods 0.000 description 11
- 238000001879 gelation Methods 0.000 description 11
- 239000000126 substance Substances 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- 238000005429 filling process Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 229920006318 anionic polymer Polymers 0.000 description 6
- 229920006317 cationic polymer Polymers 0.000 description 6
- 230000010412 perfusion Effects 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000004108 freeze drying Methods 0.000 description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000012209 synthetic fiber Substances 0.000 description 4
- 229920002994 synthetic fiber Polymers 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 230000009881 electrostatic interaction Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010345 tape casting Methods 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000009489 vacuum treatment Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01034—Non-adhesive bandages or dressings characterised by a property
- A61F13/01042—Absorbency
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a medical composite imbibing dressing and a preparation method thereof. According to the medical sponge dressing, the polyelectrolyte sponge is filled in the pores of the medical sponge to form a polyelectrolyte sponge-medical sponge composite structure, so that the self-moisturizing performance of the medical sponge dressing is improved, the problem that the traditional medical sponge is easy to seep liquid is solved, and the use experience of the medical sponge dressing is improved.
Description
Technical Field
The invention relates to the technical field of medical dressings, in particular to a medical composite imbibing dressing and a preparation method thereof.
Background
The medical dressing is a wound wrapping article and is mainly used for covering sores, wounds and other medical materials containing tertiary amine. Conventional medical dressings include natural gauze, synthetic fibers, polymeric films, foamed polymeric materials, gel dressings, alginate dressings, and the like. Compared with other materials such as natural gauze, synthetic fiber and polymeric membrane, the foamed polymeric material (medical sponge dressing) enables the medical sponge dressing to be widely used in various medical use scenes by virtue of the rapid and strong liquid absorption capacity and the mature processing scheme of the foamed polymeric material. However, the traditional medical sponge dressing has weak water-retaining capacity, and liquid is easy to seep out to contaminate clothes after being pressed, which brings inconvenience to patients.
Disclosure of Invention
The invention mainly aims to provide a medical composite liquid-absorbing dressing and a preparation method thereof, aiming at solving the problem that the liquid is easy to leak out in the traditional medical sponge dressing.
In order to achieve the purpose, the invention provides a medical composite imbibing dressing which comprises a medical sponge and polyelectrolyte sponge filled in pores of the medical sponge, wherein the polyelectrolyte sponge is formed by gelatinizing a polyelectrolyte solution and then drying.
Optionally, the medical sponge comprises any one of a polyurethane sponge, a polyvinyl alcohol sponge, a gelatin sponge, and a collagen sponge.
Optionally, the polyelectrolyte solution comprises a cationic water-soluble polymer and an anionic water-soluble polymer, wherein:
the cationic water-soluble polymer comprises at least one of polyethyleneimine, polyvinylamine, polyvinyl pyridine, polyacrylamide, chitosan oligosaccharide, chitosan, carboxymethyl chitosan, chitosan quaternary ammonium salt, chitosan hydrochloride, hydroxyethyl chitin, hydroxybutyl chitosan and succinyl chitosan;
the anionic water-soluble polymer comprises at least one of polyacrylic acid, polymethacrylic acid, polystyrene sulfonic acid, polyvinyl phosphoric acid, hyaluronic acid, polylysine, glycerophospholipid, sodium carboxymethylcellulose, sodium carboxymethyl starch, sodium alginate and carbomer.
Optionally, the polyelectrolyte solution further comprises a pH adjuster comprising at least one of citric acid, lactic acid, tartaric acid, malic acid, phosphoric acid, gluconolactone, sodium hydroxide, sodium carbonate, sodium bicarbonate, ethanolamine, ethylenediamine, a basic amino acid, sodium dihydrogen phosphate, potassium dihydrogen phosphate, carbonic acid, acetic acid, barbituric acid, tris.
In order to realize the purpose, the invention also provides a preparation method of the medical composite liquid-absorbing dressing, which comprises the following steps:
preparing a cationic water-soluble polymer solution;
preparing an anionic water-soluble polymer solution;
mixing the cationic water-soluble polymer solution with the anionic water-soluble polymer solution to form a mixed solution;
adding a pH regulator into the mixed solution, and mixing to form a polyelectrolyte solution;
and filling the polyelectrolyte solution into the pores of the medical sponge, gelatinizing the medical sponge, and drying to obtain the medical composite imbibing dressing.
Optionally, in the cationic water-soluble polymer solution, the mass concentration of the cationic water-soluble polymer is 0.5-5%;
in the anionic water-soluble polymer solution, the mass concentration of the anionic water-soluble polymer is 0.5-5%;
the volume ratio of the anionic water-soluble polymer solution to the cationic water-soluble polymer solution is 1: 10-10: 1.
Optionally, the polyelectrolyte solution is filled in the pores of the medical sponge and is gelated, and then the medical sponge is dried to prepare the medical composite imbibing dressing, wherein the polyelectrolyte solution comprises the following steps:
the mode of filling the polyelectrolyte solution in the pores of the medical sponge includes any one of blade coating, spin coating, dip coating, spray coating, pouring and injection.
Optionally, in the step of preparing the medical composite imbibing dressing by filling the polyelectrolyte solution into the pores of the medical sponge and gelling the polyelectrolyte solution, and then drying the gel, the step of filling the polyelectrolyte solution into the pores of the medical sponge comprises:
and filling the polyelectrolyte solution into the pores of the medical sponge, removing bubbles from the medical sponge, and filling the polyelectrolyte solution into the pores of the medical sponge again.
Optionally, in the step of filling the polyelectrolyte solution into the pores of the medical sponge and gelling the polyelectrolyte solution, and then drying the gel to obtain the medical composite absorbent dressing, the step of filling the polyelectrolyte solution into the pores of the medical sponge and gelling the polyelectrolyte solution comprises:
and filling the polyelectrolyte solution into the pores of the medical sponge, scraping off residual liquid on the surface after filling, and standing at room temperature for 0.5-24 h to gelatinize the polyelectrolyte solution in the pores of the medical sponge.
According to the technical scheme provided by the invention, the polyelectrolyte sponge is filled in the pores of the medical sponge to form a polyelectrolyte sponge-medical sponge composite structure, so that the self-moisturizing performance of the medical sponge dressing is improved, the problem of easy liquid seepage of the traditional medical sponge is solved, and the use experience of the medical sponge dressing is improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other related drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic flow chart illustrating one embodiment of a method for making a medical composite liquid-absorbent dressing according to the present invention;
FIG. 2 is a graph showing the results of a viscoelastic behavior test of an untreated medical sponge;
fig. 3 is a graph showing the results of the viscoelastic behavior test of the medical composite liquid-absorbent dressing prepared in the example of the present invention.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially. In addition, the meaning of "and/or" appearing throughout includes three juxtapositions, exemplified by "A and/or B", including either A or B or both A and B. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Conventional medical dressings include natural gauze, synthetic fibers, polymeric films, foamed polymeric materials, gel dressings, alginate dressings, and the like. Compared with other materials such as natural gauze, synthetic fiber and polymeric membrane, the foamed polymeric material (medical sponge dressing) enables the medical sponge dressing to be widely used in various medical use scenes by virtue of the rapid and strong liquid absorption capacity and the mature processing scheme of the foamed polymeric material. However, the traditional medical sponge dressing has weak water-retaining capacity, and liquid is easy to seep out to contaminate clothes after being pressed, which brings inconvenience to patients.
In view of the above, the present invention provides a medical composite imbibing dressing, which includes a medical sponge and a polyelectrolyte sponge filled in pores of the medical sponge, wherein the polyelectrolyte sponge is formed by gelling and drying a polyelectrolyte solution.
Traditional medical sponge dressing self ability of moisturizing is not strong, and does not possess the ability of imbibition back fast curing, often appear when the subsides are applied leading to liquid to ooze because of the pressurized, be infected with the clothing, use for the patient and bring inconvenience, the moisture evaporation that has wherein the liquid medicine is too fast simultaneously in the existence for liquid medicine in the dressing dries in the short time, the effective active time of liquid medicine is shorter, and self viscidity is not enough moreover, can't closely paste and apply, especially the position of often moving about. The polyelectrolyte is also called as polyelectrolyte and belongs to water-soluble polymers, and because the structural unit of the polyelectrolyte contains a group capable of storing, in an aqueous solution, an anionic polymer and a cationic polymer usually form a bulk compound under a proper pH condition, and when the bulk compound is formed by the polyelectrolyte with a large number of hydrophilic groups, the aqueous solution is converted from a liquid state to a gel state. The polyelectrolyte gel dressing can keep the wound surface wet and provide self-adhesion, has good compliance, and a user feels comfortable, but the polyelectrolyte gel dressing has poor mechanical property, is easy to deform after being stressed, and cannot be tightly pasted on a part which is frequently moved.
The medical sponge has the advantages that the polyelectrolyte solution is filled in the pores of the medical sponge, the polyelectrolyte solution is gelatinized and then dried to form the polyelectrolyte microporous sponge, and the polyelectrolyte microporous sponge is embedded into the medical sponge framework, so that a polyelectrolyte sponge-medical sponge composite structure is formed, namely, the medical composite imbibing dressing is integrally formed by embedding the polyelectrolyte sponge and the medical sponge, the polyelectrolyte sponge can quickly imbibe and swell into gel and is limited to imbibe and swell only in the pores of the medical sponge, so that the self-moisture retention property and the self-adhesiveness of the medical sponge dressing are improved, the problems of easy liquid seepage, difficult close application, too fast volatilization of liquid medicine and the like of the traditional medical sponge are solved, and the use experience of the medical sponge dressing is improved, meanwhile, the medical sponge provides good support for the polyelectrolyte sponge, and the mechanical strength of the medical sponge is increased, so that the composite structure provided by the invention can quickly rebound after being pressed to keep the structural integrity, and the use performance of the polyelectrolyte gel as a medical dressing is improved.
The invention provides a novel medical dressing compounded by polyelectrolyte gel and medical sponge, thereby improving various performances of the medical sponge, the scheme is suitable for various common medical sponges in the field, the invention does not limit the specific types of the medical sponges, and the medical dressing comprises any one of but not limited to polyurethane sponge, polyvinyl alcohol sponge, gelatin sponge and collagen sponge.
Specifically, in some embodiments of the present invention, the polyelectrolyte solution includes a cationic water-soluble polymer and an anionic water-soluble polymer, wherein: the cation water-soluble polymer comprises at least one of polyethyleneimine, polyvinylamine, polyvinylpyridine, polyacrylamide, chitosan oligosaccharide, chitosan, carboxymethyl chitosan, chitosan quaternary ammonium salt, chitosan hydrochloride, hydroxyethyl chitin, hydroxybutyl chitosan and succinyl chitosan, and the substances can provide cations to carry positive charges after ionization in an aqueous solution due to the existence of amino groups and other groups, can be any one of the substances, and can also be a mixture of two or more of the substances, and all the substances belong to the protection range of the invention; the anionic water-soluble polymer comprises at least one of polyacrylic acid, polymethacrylic acid, polystyrene sulfonic acid, polyvinyl phosphoric acid, hyaluronic acid, polylysine, glycerophospholipid, sodium carboxymethyl cellulose, sodium carboxymethyl starch, sodium alginate and carbomer, and the substances can provide a large amount of anions in an aqueous solution and are negatively charged due to the existence of a large amount of carboxyl groups, can be any one of the substances, and can also be a mixture of two or more of the substances, and all belong to the protection scope of the invention.
Further, the polyelectrolyte solution also comprises a pH regulator, so that the pH value of the polyelectrolyte solution can reach a value between the pKa values of the cationic polymer and the anionic polymer, and the gelation transformation of the polyelectrolyte system through electrostatic interaction is promoted. Specifically, in some embodiments of the present invention, the pH adjusting agent includes at least one of citric acid, lactic acid, tartaric acid, malic acid, phosphoric acid, gluconolactone, sodium hydroxide, sodium carbonate, sodium bicarbonate, ethanolamine, ethylenediamine, basic amino acid, sodium dihydrogen phosphate, potassium dihydrogen phosphate, carbonic acid, acetic acid, barbituric acid, and tris (hydroxymethyl) aminomethane, which may be any one of the above substances or a mixture of two or more of them, and falls within the protection scope of the present invention.
Based on the medical composite imbibition dressing provided by the invention, the invention also provides a preparation method of the medical composite imbibition dressing, which is characterized in that a polyelectrolyte solution is filled in the pores of the medical sponge, is gelatinized and then is dried to form polyelectrolyte sponge and is nested in the pores of the medical sponge, so that a polyelectrolyte sponge-medical sponge composite structure is obtained, and fig. 1 shows an embodiment of the preparation method of the medical composite imbibition dressing provided by the invention. Referring to fig. 1, in this embodiment, the method for preparing the medical composite liquid absorbing dressing comprises the following steps:
step S10, preparing a cationic water-soluble polymer solution;
step S20, preparing an anionic water-soluble polymer solution;
step S30, mixing the cation water-soluble polymer solution and the anion water-soluble polymer solution to form a mixed solution;
step S40, adding a pH regulator into the mixed solution, and mixing to form a polyelectrolyte solution;
and step S50, filling the polyelectrolyte solution into the pores of the medical sponge, gelatinizing the medical sponge, and drying to obtain the medical composite liquid-absorbing dressing.
Firstly, respectively preparing a cationic water-soluble polymer solution and an anionic water-soluble polymer solution, then mixing the cationic water-soluble polymer solution and the anionic water-soluble polymer solution according to a certain proportion, and uniformly stirring to obtain a mixed solution, wherein the sequence between the step S10 and the step S20 is not limited, and the cationic water-soluble polymer solution and the anionic water-soluble polymer solution are only required to be prepared respectively before the step S30. In addition, when the cationic water-soluble polymer solution and the anionic water-soluble polymer solution are prepared, for some substances with high difficulty in dissolving, the substances can be dissolved in an appropriate acidic or alkaline environment, for example, when chitosan is dissolved, 2% acetic acid can be added into the solutions, which is specifically referred to the prior art and is not described herein.
The polyelectrolyte gel system is different from other gel systems in that the polyelectrolyte gel system can be converted into a gel state through electrostatic interaction only when the pH value of the solution is between the pKa values of the cationic polymer and the anionic polymer, and cannot be converted from a liquid state to the gel state when the overall pH value of the solution is not within the range. Therefore, in this embodiment, a suitable pH regulator is added to the polyelectrolyte system, so that the overall pH of the solution is gradually controlled to be between pKa values of the cationic polymer and the anionic polymer, specifically, the pH regulator is added to the mixed solution obtained in step S30, and the pH regulator is usually added after being prepared into a pH regulator aqueous solution, and then is stirred and mixed uniformly to form the polyelectrolyte solution. It should be noted that, in the solution provided by the present invention, the time for the polyelectrolyte solution to gelate and the final gel strength can be controlled by controlling the molecular weight of the added polyelectrolyte, and parameters such as the liquid amount, the concentration, and different ratios of the pH adjusting agent aqueous solution, which will be specifically described with reference to the following specific examples.
It can be understood that, after the pH regulator is added into the mixed solution, since a certain time is still needed for the pH value of the whole solution to change, the whole solution still has liquid characteristics in a short time, i.e. still has fluidity, does not immediately form gel, and has processability, in the technical scheme of the invention, the prepared polyelectrolyte solution is filled into the pores of the medical sponge, and when the pH value of the solution reaches a pKa value between a cationic polymer and an anionic polymer, the whole solution is converted from a liquid state to a gel state through electrostatic interaction, so that a gelation process is completed in the pores of the medical sponge, and a polyelectrolyte gel-medical sponge compound is formed, wherein the compound is in a state that a medical sponge framework is used as a whole in appearance and polyelectrolyte gel is filled in the pores.
And then, drying the polyelectrolyte gel-medical sponge compound, wherein the drying mode includes but is not limited to drying, freeze drying and the like, and specific drying parameters are not limited so as to fully dry the material to meet the use requirement of the medical sponge. In the drying process, water in the polyelectrolyte gel is sublimated to form polyelectrolyte sponge which is embedded in the medical sponge, and finally a composite structure of the polyelectrolyte sponge and the medical sponge is formed, so that the polyelectrolyte sponge-medical sponge composite imbibing dressing is prepared.
The medical composite imbibition dressing prepared by the method is formed by nesting the polyelectrolyte sponge and the medical sponge, wherein the polyelectrolyte sponge has a microporous structure, can quickly imbibe and swell to be converted into gel, and is limited to imbibe and swell only in pores of the medical sponge, so that the self-moisturizing performance and the self-adhesiveness of the medical sponge dressing are improved, the problems of easy liquid seepage, difficult close pasting, too quick volatilization of liquid medicine and the like of the traditional medical sponge are solved, the use experience of the medical sponge dressing is improved, meanwhile, the medical sponge provides good support for the polyelectrolyte sponge, the mechanical strength of the medical sponge is increased, the composite structure provided by the invention can quickly rebound after being pressed to keep the structural integrity, and the use performance of the polyelectrolyte gel as the medical dressing is improved.
In some embodiments of the present invention, the ratio of the cationic water-soluble polymer to the anionic water-soluble polymer in the polyelectrolyte solution is: in the cationic water-soluble polymer solution, the mass concentration of the cationic water-soluble polymer is 0.5-5%; in the anionic water-soluble polymer solution, the mass concentration of the anionic water-soluble polymer is 0.5-5%; the volume ratio of the anionic water-soluble polymer solution to the cationic water-soluble polymer solution is 1: 10-10: 1.
In the process of filling the polyelectrolyte solution into the gap of the medical sponge, the polyelectrolyte solution still has fluidity and can be performed by a commonly used liquid filling process, and in particular, in some embodiments of the present invention, the polyelectrolyte solution includes, but is not limited to, any one of knife coating, spin coating, dip coating, spray coating, pouring and injection, and the specific process is easy and the filling efficiency and the expected and actual effect of the filling are correspondingly selected.
Further, in the filling process, if fill incompletely, can also be right after filling medical sponge removes the bubble, for example adopt vacuum treatment or centrifugation etc. to remove the bubble mode, then continue to fill again, until filling and finishing, scrape at last remaining liquid in medical sponge surface avoids forming polyelectrolyte gel and polyelectrolyte sponge on the surface of medical sponge, leads to medical sponge skeleton can't provide mechanical strength for the polyelectrolyte sponge, not only influences the whole outward appearance of medical sponge itself, also can influence performance.
After the polyelectrolyte solution is filled in the pores of the medical sponge, in the process that the pH value of the polyelectrolyte solution moves towards the pKa value of the cationic polymer and the pKa value of the anionic polymer, gelation can be finished at room temperature directly, and the change speed of the pH value can be increased by increasing the overall temperature of the solution, so that the gelation speed of the polyelectrolyte solution is increased. In some embodiments of the present invention, preferably, the gelation is completed at room temperature, and specifically, after the polyelectrolyte solution is filled in the pores of the medical sponge and the residual liquid on the surface is scraped off, the polyelectrolyte solution is allowed to stand at room temperature for 0.5 to 24 hours, so that the polyelectrolyte solution can be gelled in the pores of the medical sponge.
The technical solutions of the present invention are further described in detail below with reference to specific examples and drawings, it should be understood that the following examples are merely illustrative of the present invention and are not intended to limit the present invention.
Example 1
(1) Preparing a carbomer aqueous solution with the concentration of 1 weight percent and a chitosan aqueous solution with the concentration of 2.5 weight percent (2 weight percent of acetic acid is added into the chitosan aqueous solution);
(2) mixing a carbomer aqueous solution and a chitosan aqueous solution in a volume ratio of 1:1, and stirring for 2 hours to obtain a mixed solution;
(3) adding a sodium bicarbonate aqueous solution with the concentration of 1g/mL (the volume ratio of the mixed solution to the sodium bicarbonate aqueous solution is 2:1) into the mixed solution, and quickly stirring for 30s to obtain a polyelectrolyte solution;
(4) before the gelation of the polyelectrolyte solution, filling the polyelectrolyte solution into the polyurethane sponge by adopting a perfusion centrifugal filling process, scraping residual liquid on the outer surface of the sponge after the filling is finished, standing for 2 hours at room temperature to ensure that the polyelectrolyte solution is completely converted into a gel state, and then freezing and drying to prepare the medical composite imbibition dressing.
Example 2
(1) Preparing a carbomer aqueous solution with the concentration of 2 wt% and a carboxymethyl chitosan aqueous solution with the concentration of 2 wt%;
(2) mixing a carbomer aqueous solution and a carboxymethyl chitosan aqueous solution in a volume ratio of 1:1, and stirring for 2 hours to obtain a mixed solution;
(3) adding a triethanolamine solution (the volume ratio of the mixed solution to the triethanolamine solution is 30:1) into the mixed solution, and quickly stirring for 30s to obtain a polyelectrolyte solution;
(4) before the gelation of the polyelectrolyte solution, filling the polyelectrolyte solution into the polyurethane sponge by adopting a perfusion centrifugal filling process, scraping residual liquid on the outer surface of the sponge after the filling is finished, standing for 2 hours at room temperature to ensure that the polyelectrolyte solution is completely converted into a gel state, and then freezing and drying to prepare the medical composite imbibition dressing.
Example 3
(1) Preparing a sodium alginate aqueous solution with the concentration of 1 wt% and a carboxymethyl chitosan aqueous solution with the concentration of 1 wt%;
(2) mixing a sodium alginate aqueous solution and a carboxymethyl chitosan aqueous solution in a volume ratio of 1:1, and stirring for 2 hours to obtain a mixed solution;
(3) adding a gluconolactone aqueous solution with the concentration of 0.3g/mL (the volume ratio of the mixed solution to the gluconolactone aqueous solution is 5:1) into the mixed solution, and rapidly stirring for 30s to obtain a polyelectrolyte solution;
(4) before the gelation of the polyelectrolyte solution, filling the polyelectrolyte solution into the polyurethane sponge by adopting a perfusion centrifugal filling process, scraping residual liquid on the outer surface of the sponge after the filling is finished, standing for 2 hours at room temperature to ensure that the polyelectrolyte solution is completely converted into a gel state, and then freeze-drying to prepare the medical composite imbibing dressing.
Example 4
(1) Preparing polyacrylic acid aqueous solution with the concentration of 0.5 wt% and chitosan oligosaccharide aqueous solution with the concentration of 0.5 wt%;
(2) mixing a polyacrylic acid aqueous solution and a chitosan oligosaccharide aqueous solution in a volume ratio of 1:10, and stirring for 2 hours to obtain a mixed solution;
(3) adding a sodium carbonate solution with the concentration of 0.1g/mL (the volume ratio of the mixed solution to the sodium carbonate aqueous solution is 10:1) into the mixed solution, and quickly stirring for 30s to obtain a polyelectrolyte solution;
(4) before the gelation of the polyelectrolyte solution, filling the polyelectrolyte solution into the polyvinyl alcohol sponge by adopting a perfusion centrifugal filling process, scraping residual liquid on the outer surface of the sponge after the filling is finished, standing for 0.5h at room temperature to completely convert the polyelectrolyte solution into a gel state, and then freeze-drying to prepare the medical composite imbibition dressing.
Example 5
(1) Preparing a sodium carboxymethylcellulose aqueous solution with the concentration of 3 wt% and a chitosan hydrochloride aqueous solution with the concentration of 3.5 wt%;
(2) mixing sodium carboxymethylcellulose aqueous solution and chitosan hydrochloride aqueous solution in a volume ratio of 1:5, and stirring for 2h to obtain a mixed solution;
(3) adding a sodium bicarbonate aqueous solution with the concentration of 0.1g/mL (the volume ratio of the mixed solution to the sodium bicarbonate aqueous solution is 2:1) into the mixed solution, and quickly stirring for 30s to obtain a polyelectrolyte solution;
(4) before the gelation of the polyelectrolyte solution, filling the polyelectrolyte solution into the gelatin sponge by adopting a perfusion centrifugal filling process, scraping residual liquid on the outer surface of the sponge after the filling is finished, standing for 10 hours at room temperature to ensure that the polyelectrolyte solution is completely converted into a gel state, and then freezing and drying to prepare the medical composite imbibition dressing.
Example 6
(1) Preparing a carboxymethyl starch sodium aqueous solution with the concentration of 5 wt% and a chitosan quaternary ammonium salt aqueous solution with the concentration of 5 wt%;
(2) mixing a sodium carboxymethyl starch aqueous solution and a chitosan quaternary ammonium salt aqueous solution in a volume ratio of 10:1, and stirring for 2 hours to obtain a mixed solution;
(3) adding a malic acid aqueous solution with the concentration of 0.2g/mL (the volume ratio of the mixed solution to the malic acid aqueous solution is 10:1) into the mixed solution, and rapidly stirring for 30s to obtain a polyelectrolyte solution;
(4) before the gelation of the polyelectrolyte solution, filling the polyelectrolyte solution into the collagen sponge by adopting a perfusion centrifugal filling process, scraping residual liquid on the outer surface of the sponge after the filling is finished, standing for 24 hours at room temperature to ensure that the polyelectrolyte solution is completely converted into a gel state, and then freeze-drying to prepare the medical composite imbibing dressing.
The medical composite imbibition dressing prepared by the embodiment of the invention is subjected to imbibition test and mechanical property test by taking medical sponge which is not subjected to composite treatment as comparison, and the method and the result are as follows:
first, liquid absorption test
The use scene of the medical sponge is simulated, the untreated medical sponge and the medical composite imbibition dressing prepared by the embodiment are placed in the water environment, and the imbibition state, the imbibition speed, the water absorption rate and the water retention rate are observed.
Observation shows that: (1) the medical composite liquid-absorbing dressing prepared by the embodiment of the invention has larger water absorption rate which is about more than 20 times of that of untreated sponge. (2) The medical composite imbibing dressing prepared by the embodiment has strong water retention capacity, and is in a colloid state after absorbing water. (3) In terms of water retention, the medical composite absorbent dressing prepared in the example is significantly superior to the untreated sponge in that the untreated sponge can retain only about 10% of water after centrifugation by a centrifuge, while the medical composite absorbent dressing prepared in the example can retain about 70% of water, and the two have statistical differences, and specific water retention values are shown in table 1 below. (4) In terms of liquid absorption speed, the liquid absorption speed of the medical composite liquid absorption dressing prepared in the example is about 10s, and the liquid absorption speed of the untreated sponge is about 30s, which shows that the liquid absorption speed of the medical composite liquid absorption dressing prepared in the example is accelerated after the composite treatment.
Table 1 water retention test results
Second, mechanical properties
The rheological properties of the composite dressing not lyophilized in the examples were investigated using a rotary rheometer (germany HAAKE MARS 40). Cutting the gel into a cylinder with the diameter of 10mm, placing the cylinder on an aluminum alloy parallel sample seat (with the diameter of 10mm), and firstly optimizing the strain amplitude to ensure that all tests are carried out in a linear visco-elastic region (LVR) and the storage modulus (G ') and the loss modulus (G') are not influenced by strain; the dynamic storage modulus (G') and loss modulus (G ") are then measured as a function of time at selected strain amplitudes and oscillation frequencies to ensure that the measurement conditions do not disrupt the gelling process. The oscillation frequency used in the test was 1Hz and the strain was 0.001.
It should be noted that G' in the rheometer refers to the storage modulus, representing the elastic portion of the viscoelastic behavior, and describes the solid state properties of the sample; g "refers to the loss modulus, describing the viscous portion of the viscoelastic behavior, which can also be considered the liquid property of the sample.
The test results of G 'and G "of the untreated medical sponge are shown in fig. 2, and the test results of G' and G" of the medical composite liquid-absorbent dressing prepared in example are shown in fig. 3. Comparing fig. 2 and fig. 3, it can be seen that the storage modulus G' of the medical composite liquid absorbing dressing prepared by the embodiment of the present invention is significantly improved, and has higher strength and toughness compared to the untreated medical sponge.
The above is only a preferred embodiment of the present invention, and it is not intended to limit the scope of the invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention shall be included in the scope of the present invention.
Claims (9)
1. The medical composite imbibition dressing is characterized by comprising a medical sponge and a polyelectrolyte sponge filled in pores of the medical sponge, wherein the polyelectrolyte sponge is formed by gelatinizing a polyelectrolyte solution and then drying.
2. The medical composite liquid-absorbent dressing of claim 1, wherein the medical sponge comprises any one of a polyurethane sponge, a polyvinyl alcohol sponge, a gelatin sponge, and a collagen sponge.
3. The medical composite liquid absorbent dressing of claim 1, wherein the polyelectrolyte solution comprises a cationic water-soluble polymer and an anionic water-soluble polymer, wherein:
the cationic water-soluble polymer comprises at least one of polyethyleneimine, polyvinylamine, polyvinyl pyridine, polyacrylamide, chitosan oligosaccharide, chitosan, carboxymethyl chitosan, chitosan quaternary ammonium salt, chitosan hydrochloride, hydroxyethyl chitin, hydroxybutyl chitosan and succinyl chitosan;
the anionic water-soluble polymer comprises at least one of polyacrylic acid, polymethacrylic acid, polystyrene sulfonic acid, polyvinyl phosphoric acid, hyaluronic acid, polylysine, glycerophospholipid, sodium carboxymethylcellulose, sodium carboxymethyl starch, sodium alginate and carbomer.
4. The medical composite fluid absorbent dressing of claim 3, wherein the polyelectrolyte solution further comprises a pH adjusting agent comprising at least one of citric acid, lactic acid, tartaric acid, meta-tartaric acid, malic acid, phosphoric acid, gluconolactone, sodium hydroxide, sodium carbonate, sodium bicarbonate, ethanolamine, ethylenediamine, basic amino acids, sodium dihydrogen phosphate, potassium dihydrogen phosphate, carbonic acid, acetic acid, barbituric acid, tris.
5. The preparation method of the medical composite imbibing dressing is characterized by comprising the following steps:
preparing a cationic water-soluble polymer solution;
preparing an anionic water-soluble polymer solution;
mixing the cationic water-soluble polymer solution with the anionic water-soluble polymer solution to form a mixed solution;
adding a pH regulator into the mixed solution, and mixing to form a polyelectrolyte solution;
and filling the polyelectrolyte solution into the pores of the medical sponge, gelatinizing the medical sponge, and drying to obtain the medical composite imbibing dressing.
6. The method for preparing a medical composite liquid absorbent dressing as claimed in claim 5, wherein the mass concentration of the cationic water-soluble polymer in the cationic water-soluble polymer solution is 0.5-5%;
in the anionic water-soluble polymer solution, the mass concentration of the anionic water-soluble polymer is 0.5-5%;
the volume ratio of the anionic water-soluble polymer solution to the cationic water-soluble polymer solution is 1: 10-10: 1.
7. The method for preparing a medical composite liquid-absorbent dressing according to claim 5, wherein the step of filling the polyelectrolyte solution into the pores of the medical sponge and gelling the same, followed by drying, is a step of:
the mode of filling the polyelectrolyte solution in the pores of the medical sponge includes any one of blade coating, spin coating, dip coating, spray coating, pouring and injection.
8. The method for preparing a medical composite liquid absorbent dressing according to claim 5, wherein the step of filling the polyelectrolyte solution in the pores of the medical sponge and gelling the same, followed by drying, comprises the steps of:
and filling the polyelectrolyte solution into the pores of the medical sponge, removing bubbles from the medical sponge, and filling the polyelectrolyte solution into the pores of the medical sponge again.
9. The method for preparing a medical composite liquid absorbent dressing as claimed in claim 5, wherein the step of filling the polyelectrolyte solution in the pores of the medical sponge and gelling the same, followed by drying, to prepare the medical composite liquid absorbent dressing, the step of filling the polyelectrolyte solution in the pores of the medical sponge and gelling the same comprises:
and filling the polyelectrolyte solution into the pores of the medical sponge, scraping off residual liquid on the surface after filling, and standing at room temperature for 0.5-24 h to gelatinize the polyelectrolyte solution in the pores of the medical sponge.
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| US4570629A (en) * | 1982-03-17 | 1986-02-18 | University Of Illinois Foundation | Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same |
| US20030163073A1 (en) * | 2000-01-27 | 2003-08-28 | Jochem Effing | Polyelectrolyte solid system, method for the production thereof and a wound dressing |
| CN102131527A (en) * | 2008-07-18 | 2011-07-20 | 奎克-麦德技术公司 | Polyelectrolyte complex for imparting antimicrobial properties to a substrate |
| CN102223858A (en) * | 2008-10-02 | 2011-10-19 | L.R.R.&D.有限公司 | Interface layer wound dressing |
| CN102657893A (en) * | 2012-05-07 | 2012-09-12 | 浙江大学 | Medical nano-fiber sponge material and preparation method and application thereof |
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| US4570629A (en) * | 1982-03-17 | 1986-02-18 | University Of Illinois Foundation | Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same |
| US20030163073A1 (en) * | 2000-01-27 | 2003-08-28 | Jochem Effing | Polyelectrolyte solid system, method for the production thereof and a wound dressing |
| CN102131527A (en) * | 2008-07-18 | 2011-07-20 | 奎克-麦德技术公司 | Polyelectrolyte complex for imparting antimicrobial properties to a substrate |
| CN102223858A (en) * | 2008-10-02 | 2011-10-19 | L.R.R.&D.有限公司 | Interface layer wound dressing |
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