CN114949352A - Composite film with dual electrical activity and preparation method thereof - Google Patents
Composite film with dual electrical activity and preparation method thereof Download PDFInfo
- Publication number
- CN114949352A CN114949352A CN202210596700.6A CN202210596700A CN114949352A CN 114949352 A CN114949352 A CN 114949352A CN 202210596700 A CN202210596700 A CN 202210596700A CN 114949352 A CN114949352 A CN 114949352A
- Authority
- CN
- China
- Prior art keywords
- plcl
- pvdf
- composite film
- solution
- pedot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E10/00—Energy generation through renewable energy sources
- Y02E10/50—Photovoltaic [PV] energy
- Y02E10/549—Organic PV cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
Abstract
The invention discloses a composite film with dual electrical activity and a preparation method thereof, wherein the preparation method comprises the following steps: preparing a PVDF/PLCL mixed solution; a method for uniformly dispersing PDOTE nano particles in a PVDF/PLCL mixed solution; and (3) preparing a PVDF/PLCL/PEDOT piezoelectric conductive composite film. The composite film has excellent biocompatibility, mechanical property and degradation property. The conduction function can regulate and control an endogenous bioelectric field and stimulate the maturation of Schwann cells and the myelination of axons; piezoelectric power generation provides noninvasive electrical stimulation for the body, and the noninvasive electrical stimulation and the conduction effect are cooperated to promote the regeneration of peripheral nerves.
Description
Technical Field
The invention relates to the technical field of biomedical materials, in particular to a composite film with dual electrical activity and a preparation method thereof.
Background
At present, collagen, acellular matrix and the like are used as base materials for repairing peripheral nerves in the market to prepare film-shaped or tubular products, however, nerve repair is different from other tissue repair, nerve tissues are in extremely complex electrical microenvironments, electricity generation phenomenon is accompanied in the process of signal transmission of nerves, endogenous biological electric fields play an important role in mediating cell activities, and electric signals are one of important modes of neuron information transmission. Therefore, the conductive material is introduced into the peripheral nerve repair material, the endogenous electric field is regulated and controlled, and the conduction of the electric signal is promoted, so that the method has a very great application prospect. Poly (3, 4-ethylenedioxythiophene) (PEDOT) is a derivative of polythiophene, which has good electrical conductivity and biocompatibility, and is an excellent choice for using conductive materials for peripheral nerve repair.
Exogenous electrical stimulation of damaged peripheral nerves is the most common non-surgical treatment in the clinic. The electrical stimulation can promote the differentiation of nerve cells, promote the release of neurotrophic factors, accelerate the regeneration and myelination of transected axons, even regulate immune microenvironment and inhibit the inflammatory environment of damaged tissues. The self-generating peripheral nerve scaffold can continuously release voltage after being transplanted into a body, and open electrical stimulation in operation or postoperative traumatic electrical stimulation is not needed. The piezoelectric material is a crystal material capable of converting mechanical energy into electric energy, and polyvinylidene fluoride (PVDF) is a representative piezoelectric polymer, and has the advantages of good flexibility, low density, low impedance, high piezoelectric voltage constant, and the like. Is an excellent choice in designing a nerve scaffold with a noninvasive self-generating system.
In order to avoid the problem of requiring secondary surgical removal of a stent for peripheral nerve repair, it is also desirable that the stent has excellent degradability and that the degradation products are absorbable in vivo. The PLCL is a degradable artificially synthesized high polymer material, has certain degradation performance and good mechanical property, has biological inertia, and can not cause serious inflammatory reaction after being implanted. The material can be used as the material of the peripheral nerve scaffold, and can meet the requirements of mechanical support and suture resistance in the repair process.
In view of the above, the invention develops a composite film with non-invasive self-generation, capability of providing electrical stimulation in vivo, conductivity and capability of promoting the conduction of endogenous electrical signals, and having both self-generation and conductivity dual electrical activity, aiming at the current situation that the current product is difficult to regulate and control the bioelectric field and microenvironment. The invention can meet the requirements of suture strength and in-vivo mechanical regeneration, and can also synergistically promote the regeneration and myelination process of axons through electrical stimulation and conductivity, thereby providing a new scheme for repairing peripheral nerve defects.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a composite film which can regulate and control an endogenous bioelectric field and has dual electrical activity of self-generation and conduction and a preparation method thereof. The composite film prepared by the method has excellent biocompatibility and mechanical property, the self electric conduction function of the composite film can stimulate the differentiation of Schwann cells and the elongation of axons, and the piezoelectric function can directly give electrical stimulation to tissues in vivo under the noninvasive condition, so that the myelination process of axons is further promoted. The composite film has the conductive and spontaneous electrical properties to synergistically promote the regeneration of peripheral nerves.
In order to realize the purpose, the technical scheme provided by the invention is as follows: a preparation method of a composite film with dual electrical activity comprises the following steps:
1) dissolving PVDF in an N, N-dimethylformamide solution to obtain a PVDF solution; dissolving PLCL into an N, N-dimethylformamide solution to obtain a PLCL solution;
2) mixing the PLCL solution obtained in the step 1) with a PVDF solution to obtain a PVDF/PLCL mixed solution;
3) adding a PEDOT nanoparticle dispersion liquid into the PVDF/PLCL mixed solution obtained in the step 2) to obtain a PVDF/PLCL/PEDOT mixed solution;
4) pouring the PVDF/PLCL/PEDOT mixed solution obtained in the step 3) into a glass dish, and drying to obtain a PVDF/PLCL/PEFDOT composite film;
5) washing the PVDF/PLCL/PEFDOT composite film obtained in the step 4) by using absolute ethyl alcohol, and washing away residual solvent to obtain the composite film with piezoelectric and conductive dual electrical activity.
Further, in the step 1), the concentration of the PVDF solution is 10% (w/t), and stirring and heating are carried out for 2-4 hours at 65 ℃ in the dissolving process; the concentration of the PLCL solution is 10 percent (w/t), and the PLCL solution needs to be stirred and heated for 2 to 4 hours at 65 ℃ in the dissolving process.
Further, in the step 2), the mixing ratio of PVDF/PLCL in the PVDF/PLCL mixed solution is 3: 7/2: 8/4:6, and stirring and heating at 65 ℃ for 2-4 hours during the mixing process.
Further, in the step 3), the content of the PEDOT nanoparticle dispersion liquid in the PVDF/PLCL/PEDOT mixed solution is 4% -8%, and the PEDOT nanoparticle dispersion liquid needs to be slowly added while stirring in the process of adding the PEDOT nanoparticle dispersion liquid, and after the PEDOT nanoparticle dispersion liquid is added, the PEDOT nanoparticle dispersion liquid needs to be heated, stirred and dispersed for 30-90min at 65 ℃.
Further, in the step 4), the drying time is more than 12h, and the drying temperature is 58 ℃.
The invention also provides a composite film which is prepared by the method and has piezoelectric and conductive dual electrical activity (self-generating and conductive integration) and is applied to peripheral nerve repair.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the composite film prepared by the method has the conductivity, can promote the conduction of endogenous electric signals, stimulate the differentiation of Schwann cells and the elongation of axons, has no wound and self-electricity generation, can provide electric stimulation in vivo without embedding an external power supply or carrying out traumatic electric stimulation, and promotes the myelination process of axons under the synergistic conduction effect. In addition, the composite film has excellent biocompatibility and mechanical property, has the advantage of suture resistance, and is convenient for meeting the requirement of transplanting the composite film into a body.
Drawings
Fig. 1 is a scanning electron microscope photograph showing that the piezoelectric conductive composite film obtained in example 1 has a porous structure.
Fig. 2 is a graph showing the electric conductivity of the piezoelectric conductive composite film obtained in example 1.
Fig. 3 is an X-ray diffraction characterization diagram of a piezoelectric conductive composite film having a β piezoelectric phase crystal obtained in example 1.
Fig. 4 is a characteristic diagram of the piezoelectric power generation capability of the piezoelectric conductive composite film obtained in example 1.
Fig. 5 is a diagram illustrating evaluation of cell compatibility of the piezoelectric conductive composite thin film obtained in example 1.
FIG. 6 is a graph showing tensile properties of films of different groups obtained in example 1.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, but the embodiments of the present invention are not limited thereto. Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art.
Example 1
1) Weighing a certain amount of PVDF, dissolving the PVDF in an N, N-dimethylformamide solution, heating and stirring the solution for 3 hours at 65 ℃ to obtain a PVDF solution with the concentration of 10% (w/t);
2) weighing a certain amount of PLCL, dissolving in N, N-dimethylformamide solution, heating and stirring at 65 ℃ for 3 hours to obtain PLCL solution with the degree of 10% (w/t);
3) mixing the PLCL solution and the PVDF solution obtained in the steps 1) and 2) according to the weight ratio of 7: 3, heating and stirring for 3 hours at 65 ℃ to obtain a PVDF/PLCL mixed solution;
4) slowly adding the PEDOT nanoparticle dispersion liquid into the PVDF/PLCL mixed solution obtained in the step 3), wherein the addition amount accounts for 5% of the total volume, and heating and stirring at 65 ℃ for 30min to obtain the PVDF/PLCL/PEDOT mixed solution;
5) pouring the mixed solution obtained in the step 4) into a glass dish, and drying at 58 ℃ for 12 h. Obtaining a PVFG/PLVL/PEFDOT composite film;
6) and (3) cleaning the composite film obtained in the step 5) by using absolute ethyl alcohol, and washing away residual solvent to obtain the composite film (the piezoelectric conductive composite film for short) with piezoelectric conductive dual electrical activity, which is applied to repairing peripheral nerves.
Fig. 1 is a scanning electron microscope image of the piezoelectric conductive composite film obtained in this example, which has a porous structure. FIG. 2 is a graph showing the results of measuring the electrical conductivity of the prepared composite films at different proportions of the amount of PEDOT added by the four-probe method in this example, and showing that the composite films containing 5% of PEDOT can reach 1X 10 -7 In the s/cm scale. Fig. 3 is a graph showing that whether or not β -type crystal of PVDF is formed in the composite thin film by XRD in this example, and the result shows that a diffraction peak appears around 20 ° where the β -type crystal is formed, demonstrating that β -type crystal having good piezoelectric properties is formed in the composite thin film. In this example, the composite film emits a voltage having an average value of 100mv under a mechanical pressure of 0.1N applied to the composite film, as measured using an oscilloscope, and this result indicates that the composite film has a piezoelectric effect. FIG. 5 is a graph showing quantitative data on the measurement of cell compatibility using CCK-8 for the composite film prepared in this example, and the results show that the cells can be normally proliferated on the composite film and that the composite film also has some effect of promoting cell proliferation relative to the control group. FIG. 6 is a test chart obtained by performing a tensile test on the composite film prepared in the example, and the result shows that the composite film retains the high strength of the PLCL/PVDF film and the good toughness of the PLCL, the maximum tensile stress of the composite film can reach 15.4MPa, the extensibility can reach 681% or more, and the elastic modulus is 3.2 MPa.
Example 2
1) Weighing a certain amount of PVDF, dissolving the PVDF in an N, N-dimethylformamide solution, heating and stirring the solution for 2 hours at 65 ℃ to obtain a PVDF solution with the concentration of 10% (w/t);
2) weighing a certain amount of PLCL, dissolving in N, N-dimethylformamide solution, heating and stirring at 65 ℃ for 2 hours to obtain PLCL solution with the degree of 10% (w/t);
3) mixing the PLCL solution obtained in the step 1) and the step 2) with the PVDF solution according to the ratio of 8:2, heating and stirring at 65 ℃ for 2 hours to obtain a PVDF/PLCL mixed solution;
4) slowly adding the PEDOT nanoparticle dispersion liquid into the PVDF/PLCL mixed solution obtained in the step 3), wherein the addition amount accounts for 8% of the total volume, and heating and stirring at 65 ℃ for 90min to obtain the PVDF/PLCL/PEDOT mixed solution;
5) pouring the mixed solution obtained in the step 4) into a glass dish, and drying at 58 ℃ for 12 h. Obtaining a PVFG/PLVL/PEFDOT composite film;
6) and (3) cleaning the composite film obtained in the step 5) by using absolute ethyl alcohol, and washing away residual solvent to obtain the composite film (the piezoelectric conductive composite film for short) with piezoelectric conductive dual electrical activity, which is applied to repairing peripheral nerves.
Example 3
1) Weighing a certain amount of PVDF, dissolving the PVDF in an N, N-dimethylformamide solution, heating and stirring the solution for 4 hours at 65 ℃ to obtain a PVDF solution with the concentration of 10% (w/t);
2) weighing a certain amount of PLCL, dissolving in N, N-dimethylformamide solution, heating and stirring at 65 ℃ for 4 hours to obtain PLCL solution with the degree of 10% (w/t);
3) mixing the PLCL solution obtained in the step 1) and the step 2) with the PVDF solution according to the proportion of 6:4, heating and stirring for 4 hours at 65 ℃ to obtain a PVDF/PLCL mixed solution;
4) slowly adding the PEDOT nanoparticle dispersion liquid into the PVDF/PLCL mixed solution obtained in the step 3), wherein the addition amount accounts for 4% of the total volume, and heating and stirring at 65 ℃ for 60min to obtain the PVDF/PLCL/PEDOT mixed solution;
5) pouring the mixed solution obtained in the step 4) into a glass dish, and drying at 58 ℃ for 12 h. Obtaining a PVFG/PLVL/PEFDOT composite film;
6) and (4) cleaning the composite film obtained in the step 5) by using absolute ethyl alcohol, and washing away residual solvent to obtain the composite film (the composite film is called as a piezoelectric conductive composite film for short) with piezoelectric conductive dual electrical activity, which is applied to repairing peripheral nerves.
Example 4
1) Weighing a certain amount of PVDF, dissolving the PVDF in an N, N-dimethylformamide solution, heating and stirring the solution for 4 hours at 65 ℃ to obtain a PVDF solution with the concentration of 10% (w/t);
2) weighing a certain amount of PLCL, dissolving in N, N-dimethylformamide solution, heating and stirring at 65 ℃ for 4 hours to obtain PLCL solution with the degree of 10% (w/t);
3) mixing the PLCL solution obtained in the step 1) and the step 2) with the PVDF solution according to the proportion of 6:4, heating and stirring for 4 hours at 65 ℃ to obtain a PVDF/PLCL mixed solution;
4) slowly adding the PEDOT nanoparticle dispersion liquid into the PVDF/PLCL mixed solution obtained in the step 3), wherein the addition amount accounts for 6% of the total volume, and heating and stirring at 65 ℃ for 60min to obtain the PVDF/PLCL/PEDOT mixed solution;
5) pouring the mixed solution obtained in the step 4) into a glass dish, and drying at 58 ℃ for 12 h. Obtaining a PVFG/PLVL/PEFDOT composite film;
6) and (3) cleaning the composite film obtained in the step 5) by using absolute ethyl alcohol, and washing away residual solvent to obtain the composite film (the piezoelectric conductive composite film for short) with piezoelectric conductive dual electrical activity, which is applied to repairing peripheral nerves.
The examples of the present invention are given for clarity of illustration only, and are not intended to limit the embodiments of the present invention. Other variants and modifications of the above-described embodiments will be obvious to those skilled in the art, and it is not necessary or necessary to exhaustively enumerate all embodiments herein. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (6)
1. A preparation method of a composite film with dual electrical activity is characterized by comprising the following steps:
1) dissolving PVDF in an N, N-dimethylformamide solution to obtain a PVDF solution; dissolving PLCL in an N, N-dimethylformamide solution to obtain a PLCL solution;
2) mixing the PLCL solution obtained in the step 1) with a PVDF solution to obtain a PVDF/PLCL mixed solution;
3) adding PEDOT nanoparticles into the PVDF/PLCL mixed solution obtained in the step 2) to obtain a PVDF/PLCL/PEDOT mixed solution;
4) pouring the PVDF/PLCL/PEDOT mixed solution obtained in the step 3) into a glass dish, and drying to obtain a PVDF/PLCL/PEFDOT composite film;
5) washing the PVDF/PLCL/PEFDOT composite film obtained in the step 4) by using absolute ethyl alcohol, and washing away residual solvent to obtain the composite film with piezoelectric conductive dual electrical activity.
2. The method of claim 1, wherein: in the step 1), the concentration of the PVDF solution is 10% (w/t), and stirring and heating are carried out for 2-4 hours at 65 ℃ in the dissolving process; the concentration of the PLCL solution is 10 percent (w/t), and the PLCL solution needs to be stirred and heated for 2 to 4 hours at 65 ℃ in the dissolving process.
3. The method of claim 1, wherein: in the step 2), the mixing ratio of the PVDF and the PLCL in the PVDF/PLCL mixed solution is 3: 7/2: 8/4:6, and stirring and heating at 65 ℃ for 2-4 hours during the mixing process.
4. The production method according to claim 1, characterized in that: in the step 3), the content of PEDOT nano particles in the PVDF/PLCL/PEDOT mixed solution is 4% -8%, and the PEDOT/PSS nano particles are slowly added while stirring, and are heated, stirred and dispersed for 30-90min at 65 ℃ after being added.
5. The method of claim 1, wherein: in the step 4), the drying time is more than 12h, and the drying temperature is 58 ℃.
6. A piezoelectric-conductive dual electroactive composite film for repairing peripheral nerves, prepared by the method of any one of claims 1 to 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210596700.6A CN114949352A (en) | 2022-05-30 | 2022-05-30 | Composite film with dual electrical activity and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210596700.6A CN114949352A (en) | 2022-05-30 | 2022-05-30 | Composite film with dual electrical activity and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114949352A true CN114949352A (en) | 2022-08-30 |
Family
ID=82957233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210596700.6A Pending CN114949352A (en) | 2022-05-30 | 2022-05-30 | Composite film with dual electrical activity and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114949352A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920672A (en) * | 2016-04-26 | 2016-09-07 | 四川大学 | Conductive parallel fiber membrane capable of promoting rapid repair of peripheral nervous tissues and preparation method of conductive parallel fiber membrane |
| CN106924820A (en) * | 2017-03-15 | 2017-07-07 | 武汉理工大学 | TA-HA composite nerve conduit with electric activity and preparation method thereof |
| CN111269447A (en) * | 2020-01-21 | 2020-06-12 | 华南理工大学 | Conductive nerve repair material with micro-nano topological structure and preparation method and application thereof |
| WO2022032203A1 (en) * | 2020-08-07 | 2022-02-10 | The Trustees Of The Stevens Institute Of Technology | Conductive scaffolds for guided neural network formation |
| CN114344564A (en) * | 2021-12-07 | 2022-04-15 | 华南理工大学 | Bionic multi-channel electroactive nerve conduit and preparation method thereof |
| CN114533953A (en) * | 2022-01-24 | 2022-05-27 | 华南理工大学 | Nanoparticle composite hydrogel nerve conduit and preparation method thereof |
-
2022
- 2022-05-30 CN CN202210596700.6A patent/CN114949352A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920672A (en) * | 2016-04-26 | 2016-09-07 | 四川大学 | Conductive parallel fiber membrane capable of promoting rapid repair of peripheral nervous tissues and preparation method of conductive parallel fiber membrane |
| CN106924820A (en) * | 2017-03-15 | 2017-07-07 | 武汉理工大学 | TA-HA composite nerve conduit with electric activity and preparation method thereof |
| CN111269447A (en) * | 2020-01-21 | 2020-06-12 | 华南理工大学 | Conductive nerve repair material with micro-nano topological structure and preparation method and application thereof |
| WO2022032203A1 (en) * | 2020-08-07 | 2022-02-10 | The Trustees Of The Stevens Institute Of Technology | Conductive scaffolds for guided neural network formation |
| CN114344564A (en) * | 2021-12-07 | 2022-04-15 | 华南理工大学 | Bionic multi-channel electroactive nerve conduit and preparation method thereof |
| CN114533953A (en) * | 2022-01-24 | 2022-05-27 | 华南理工大学 | Nanoparticle composite hydrogel nerve conduit and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bagheri et al. | Tissue engineering with electrospun electro-responsive chitosan-aniline oligomer/polyvinyl alcohol | |
| Dong et al. | Conductive hydrogel for a photothermal-responsive stretchable artificial nerve and coalescing with a damaged peripheral nerve | |
| Cui et al. | In vitro study of electroactive tetraaniline-containing thermosensitive hydrogels for cardiac tissue engineering | |
| US11511018B2 (en) | Conductive biomimetic skin scaffold material with self-repairing function and a method of preparing the same | |
| Li et al. | Bioprinted anisotropic scaffolds with fast stress relaxation bioink for engineering 3D skeletal muscle and repairing volumetric muscle loss | |
| CN113174074B (en) | Conductive silk fibroin film and preparation method and application thereof | |
| CN113150561B (en) | Collagen-based biological ink for 3D biological printing and preparation method and application thereof | |
| CN111632198A (en) | Self-crosslinking hyaluronic acid and gelatin composite hydrogel injection and preparation method and application thereof | |
| Yang et al. | Minimally invasive bioprinting for in situ liver regeneration | |
| Wan et al. | Biodegradability of conducting chitosan-g-polycaprolactone/polypyrrole conduits | |
| Liu et al. | Fabrication of carboxylic graphene oxide-composited polypyrrole film for neurite growth under electrical stimulation | |
| Geng et al. | Silk fibroin/polyacrylamide-based tough 3D printing scaffold with strain sensing ability and chondrogenic activity | |
| CN114949352A (en) | Composite film with dual electrical activity and preparation method thereof | |
| Han et al. | A 3D printable gelatin methacryloyl/chitosan hydrogel assembled with conductive PEDOT for neural tissue engineering | |
| Zheng et al. | Integrated piezoelectric/conductive composite cryogel creates electroactive microenvironment for enhanced bone regeneration | |
| Torris et al. | Polysaccharide hydrogel incorporated carbon nanofiber microelectrode for designing neural interfaces | |
| CN114796601B (en) | Composite piezoelectric film for inducing bone regeneration and preparation method and application thereof | |
| Sha et al. | Multi-Functionalized Self-Bonding MXene for Minimal-invasive Jet-injected Neural Interface and Tissue Healing | |
| CN114099786A (en) | Preparation method of exosome-loaded electroactive hydrogel dressing | |
| KR20220030564A (en) | Functional hydrogel cross-linked with tannic acid and alginic acid and its manufacturing method | |
| CN114504683A (en) | Injectable bioactive composite conductive hydrogel and preparation method and application thereof | |
| CN112791235A (en) | Conductive graphene polymer patch and preparation method thereof | |
| Trueman et al. | Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing | |
| Urbanchek et al. | Conduction properties of decellularized nerve biomaterials | |
| CN105963769B (en) | Medical ovalbumin hydrogel adhesive and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |