CN114949120A - A topical composition for treating various pains, and its preparation method - Google Patents

A topical composition for treating various pains, and its preparation method Download PDF

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CN114949120A
CN114949120A CN202110188280.3A CN202110188280A CN114949120A CN 114949120 A CN114949120 A CN 114949120A CN 202110188280 A CN202110188280 A CN 202110188280A CN 114949120 A CN114949120 A CN 114949120A
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composition
oil
cbd
carrier
external application
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王飞
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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Abstract

The invention provides an external composition for skin external application aiming at various pains, which takes plant extracts as core functional components, and the composition comprises 0.1-25 parts of arnica extract, 0.01-25 parts of thermal sensation agent, 0.01-25 parts of full-spectrum CBD oil or pure CBD powder, 0.1-25 parts of camphor, 0.1-5 parts of penetration enhancer, 0.1-30 parts of auxiliary component and 40-90 parts of carrier. The composition can be made into various suitable compositions, such as liquid, gel, paste, polymer liquid film-forming agent or patch.

Description

A topical composition for treating various pains, and its preparation method
[ technical field ] A method for producing a semiconductor device
The invention relates to a skin external composition for various pains, in particular to a skin external composition for various pains, which takes plant extracts as core functional components, and belongs to the field of personal care products and/or medicines and/or medical appliances.
[ background of the invention ]
Industrial hemp has a long history as a drug, which dates back several thousand years. Today, the therapeutic properties of CBD, cannabidiol, is being tested and confirmed by scientists and physicians worldwide, and CBD is a safe, non-addictive substance.
Cannabidiol (CBD) is extracted from industrial marijuana, and has anticonvulsant, sedative, hypnotic, anxiolytic, antipsychotic, anti-inflammatory and neuroprotective effects, and no mental effect, and the binding ability of CBD to CB1 and CB2 receptor is lower than that of Tetrahydrocannabinol (THC).
Cannabinoids for use in the treatment of neuropathic pain are disclosed in patent CN103533930A, which prior art discloses the use of cannabichromene, cannabigerol, cannabidivarin and/or tetrahydrocannabinol in the treatment of neuropathic pain.
A thin film mucoadhesive dosage form for administering cannabis formulations is disclosed in patent CN038137291, where it is mentioned that the formulation is capable of treating and ameliorating dysmenorrhea. The preparation comprises at least one component selected from the group consisting of tetrahydrocannabinol, cannabidiol, cannabinol, and cannabichromes.
Patent US20160256411a1 discloses a method of treating a human disease state or condition by administering a cannabinoid drug to the back of the neck of a human patient.
Patent CN105031563A discloses a blood stasis removing wine, which is prepared by adding 240 parts of hemp seed powder into 5000 parts of white spirit to prepare a medicinal liquor for treating dysmenorrhea.
Although a series of pharmaceutical compositions containing cannabidiol and/or cannabidivarin have been developed, none of the existing compositions are satisfactory for the treatment of various pains. For example, CBD cannot be rapidly absorbed in oral drugs and releases the drug at the desired site; sprays or aerosols often contain irritating excipients and cannot achieve the purpose of continuous administration; alcohol in the traditional Chinese medicine wine can stimulate gastric mucosa and hurt the central nervous system of people, and particularly for juveniles and teenagers in the stage of students, the alcohol can affect the physical development and learning state.
In order to overcome the defects in the prior art, the invention provides a plant extract composition aiming at various pains.
[ summary of the invention ]
The invention aims to provide a safe plant extract composition for external application to the skin, which can be used for treating various pains.
The composition comprises arnica extract, a thermogenic agent, camphor and cannabis extract full spectrum CBD oil or pure CBD powder.
The product is moisture-retaining and non-greasy, is a pure plant-based product, is added with a transdermal enhancer extracted from pure plants, does not contain any synthetic pigment or essence, and is added with auxiliary components consisting of part or all of cinnamon, motherwort herb, argyi leaf, mint, rosemary, basil, grapefruit, chamomile, ruta graveolens, witch hazel (witch hazel) bark/leaf/twig extracts, cymbidium hybridum oil, eucalyptus globulus leaf oil, lemon grass seed oil, peppermint oil and rosemary leaf oil.
The product is obtained from industrial hemp extract, has zero THC content, and contains various cannabinoids, terpenes and flavonoids. The other main ingredients of the product, arnica extract and thermal sensate, have analgesic effect, and Camphora can relieve inflammation.
The present invention and the preparation method thereof are described in detail below with reference to the technical schemes of the compositions.
The technical scheme is as follows:
the present invention provides a safe plant extract composition for various pains. The technical scheme is that the formula of the composition is as follows (based on the total weight of 100 parts):
Figure BSA0000233755290000021
the ARNICA (ARNICA MONTANA) flower extract can relieve pain caused by muscle spasm or arthritis. Can be used for treating skin wound and allergy. The arnica extract is mainly used for treating extravasated blood, sprain, myalgia, rheumatalgia and stimulating the immune system and is suitable for producing tinctures for treating muscle soreness and bruise. In addition, many natural health nutraceuticals also contain arnica components. The arnica is an effective treatment folk prescription and is particularly effective for treating extravasated blood.
The heat-sensitive agent can be one or a plurality of compositions of capsaicin, synthetic capsaicin, zingerone, vanillyl butyl ether and the like, wherein the capsaicin is preferred. The chemical name of capsaicin is trans-8-methyl-N-vanillyl-6-nonenamide, and the chemical formula is C18H27NO3, which is the active ingredient of capsicum. Has the effects of diminishing inflammation, easing pain, anaesthesia, giving up drug, and the like, has the same analgesic effect as morphine, is longer than morphine, and has obvious curative effects on post-herpetic neuralgia, trigeminal neuralgia, diabetic neuralgia, rheumatoid arthritis, osteoarthritis, psoriasis, alopecia, and the like. In addition, capsaicin can also inhibit malignant tumor, and has special effects in treating dermatosis and reducing weight.
The Full Spectrum CBD Oil described in the formula is a Hemp leaf extract which is extracted from industrial Hemp by an organic solvent or a supercritical carbon dioxide technology and is not further processed, is rich in active ingredients such as various cannabinoids, flavones, sterols and the like, is often called Full Spectrum industrial Hemp Oil Full Spectrum Hemp Oil, and the active ingredient is Cannabidiol (CBD) which is a compound naturally existing in industrial Hemp resin flowers.
The CBD powder of the invention, English: cannabidiaol (translated in Chinese to cannabidiol or cannabidiol, also known as Cannabis sincere feeling) is a pure natural ingredient extracted from industrial cannabis plants. The molecular formula of cannabidiol is C21H30O 2. The character is white to light yellow resin or crystal, the melting point is 66-67 ℃, the resin is almost insoluble in water, and the resin is dissolved in organic solvents such as ethanol, methanol, ether, benzene, chloroform and the like. The CBD processed by the nanocrystallization and preparation instant technology becomes a water-soluble CBD product with the characteristics of nanoscale, high content, high solubility, rapid dissolution, wide application, clarification and transparency after water dissolution, and the like.
The effective content of cannabidiol in the full-spectrum CBD oil or CBD powder is 5% -99%.
The camphor is a granular substance prepared by distilling and refining roots, stems, branches and leaves of Cinnamomum camphora (L.) Camphora of Lauraceae. Has the effects of dredging orifices, benefiting qi stagnation, removing filth, killing parasites, relieving itching, and relieving swelling and pain.
The transdermal enhancer is selected from L40 transdermal agent, azone, volatile oil, 1, 3-dimethyl-2-imidazolidinone (DMI), propylene glycol, ethanol and oleic acid. The skin penetration enhancer is preferably an L40 transdermal agent produced by Beijing Jieliekang pharmaceutical biology Limited company, raw materials and auxiliary materials of the transdermal agent are synthesized by food and plant extracts, L40 is an amphiphilic type (the transdermal agent can be dissolved in both oil and water) transdermal enhancer (can promote the absorption of fat (oil) soluble products and water soluble products), and the amphiphilic type and amphiphilic type oily and water soluble transdermal agent L40 is more excellent than S6 in the aspects of high efficiency, safety, environmental protection, green and the like, and particularly comprehensively surpasses the traditional transdermal enhancer in the aspects of water solubility, stability, effective component concentration, clarity after products are added and the like.
The auxiliary components of the invention are composed of part or all of cinnamon, motherwort, folium artemisiae argyi, mint, rosemary, basil, grapefruit, chamomile, ruta graveolens, witch hazel (witch hazel) bark/leaf/twig extract, cymbidium hybridum oil, eucalyptus globulus leaf oil, lemon grass seed oil, peppermint oil and rosemary leaf oil.
The composition can be in the form of liquid, gel, paste, high molecular liquid film-forming agent or patch. Thus, it will be appreciated by those skilled in the art that the carrier of the present invention may be any suitable carrier for topical compositions.
For example, when the composition is in the form of a paste, the topical carrier is selected from one or a combination of two or more of cetyl alcohol, petrolatum, liquid paraffin, glyceryl monostearate, glycerin, ethylparaben, triethanolamine, ethylparaben, lanolin, and stearic acid.
When the composition is in a gel form, the external carrier is one or a combination of more than two of carbomer, polyvinyl alcohol, carboxymethyl cellulose and sodium salt thereof, polyacrylic acid and sodium salt thereof, glycerol and ethanol.
When the composition is a patch, the external carrier is one or more of hot melt pressure sensitive adhesive, rubber, polymer hydrogel, medical adhesive tape and acrylate pressure sensitive adhesive.
When the composition is a medical or sanitary product, the carrier can also be one or the combination of more than two of yarns, cotton threads and non-woven fabrics.
When the composition is in liquid form, the topical carrier is selected from one or more of alcoholic solution, such as ethanol solution, glycerol, etc., ethers, such as polyoxyethylene alkyl ether, etc., esters, such as dibasic acid diester, vegetable oils, such as corn oil, and olive oil.
When the composition is a high-molecular liquid film-forming agent, the external carrier is selected from several combinations of medical acrylic resin, polyvinyl alcohol, triethanolamine, glycerol, ethanol, EVA, methylcellulose, a plasticizer, purified water and the like.
In one embodiment of the present invention, the carrier may further contain an adhesive, a filler, a humectant, a crosslinking agent, a colorant, a pH adjuster, a thickener, a preservative, and the like. For example, the adhesive can be selected from one or any combination of more than two of gelatin, sodium alginate, acacia, starch, methyl cellulose, carboxymethyl cellulose and sodium salt thereof, polyvinyl alcohol, polyethylene glycol, polyvinylpyrrolidone, carbomer, polyacrylic acid and sodium salt thereof; the filler can be one or any combination of more than two of zinc oxide, micro silica gel, calcium carbonate, diatomite and titanium dioxide; the humectant can be any one or the combination of more than two of glycerol, propylene glycol, sorbitol and polyethylene glycol; the cross-linking agent can be any one or the combination of more than two of calcium hydroxide, aluminum trichloride, aluminum glycinate and disodium ethylene diamine tetraacetate.
[ detailed description ] embodiments
To further illustrate the objects, aspects and advantages of the present invention, we shall now describe the invention with reference to the following specific examples, which are only for better illustrating the patent of the present invention and are not intended to limit the scope of the present invention. All other embodiments obtained by those skilled in the art without making any inventive step are within the scope of the present invention.
Figure BSA0000233755290000041
Example 1 cream for external application to the skin for various pains and preparation thereof.
The skin external composition for various pains is cream, and the cream comprises the following components in percentage by weight of 100: 2 parts of arnica extract, 0.5 part of capsaicin, 1 part of full-spectrum CBD oil, 1 part of camphor, 0.5 part of penetration enhancer, 2 parts of auxiliary component and 93 parts of carrier.
The oil phase in the carrier is lanolin, stearic acid and liquid paraffin with the mass ratio of 1.5: 2.5: 1.7, and the water phase in the carrier is glycerin, ethylparaben and carbomer with the mass ratio of 7: 1.
Mixing lanolin, stearic acid and liquid paraffin uniformly, heating to 65-90 ℃, and dissolving completely to obtain an oil phase; mixing glycerol, ethylparaben and carbomer with part of water, and heating to 65-90 ℃ to obtain a water phase; adding the oil phase into the water phase, stirring to obtain cream carrier, adding other components into the cream carrier, and stirring to obtain topical cream.
Example 2 liquid paint for external application to skin for various pains and preparation thereof
The external composition for skin aiming at various pains is externally applied in liquid, and the external composition for skin aiming at various pains comprises the following components in percentage by weight of 100: 2.5 parts of arnica extract, 0.5 part of capsaicin, 0.5 part of pure CBD powder, 1.5 parts of camphor and 1 part of transdermal enhancer, wherein the transdermal enhancer is L40 transdermal agent, the auxiliary component is 2.5 parts, and the carrier is 91.5 parts.
The carrier is glycerol and ethanol with the mass ratio of 1: 1. Dissolving the above components in mixed solution of glycerol and ethanol, and stirring to obtain liquid to obtain topical liquid liniment.
Example 3 skin external patch for various pains and preparation thereof
The external composition for skin aiming at various pains is a patch-shaped external composition, a backing layer is non-woven fabric, a protective layer is release paper, and a composition storage layer is composed of the following components in a weight ratio of 100: 2 parts of arnica extract, 1 part of capsaicin, 1 part of pure CBD powder, 1.5 parts of camphor and 2 parts of transdermal enhancer, wherein the transdermal enhancer is L40 transdermal agent, the auxiliary component is 2.5 parts, and the carrier is 90 parts.
The carrier of the drug storage layer is hot-melt pressure-sensitive adhesive, and the hot-melt pressure-sensitive adhesive is prepared by weighing styrene-butadiene rubber, a tackifier (hydrogenated rosin glyceride and pentaerythritol ester of rosin with the mass ratio of 1: 1) and squalane according to the mass ratio of 4: 3: 2.5, heating for melting, and mixing uniformly. Uniformly mixing cannabidiol and azone, uniformly mixing with hot-melt pressure-sensitive adhesive, pouring the mixture into a coating machine, uniformly coating on non-woven fabric of a back lining layer, and covering with protective layer release paper to obtain the patch.
Example 4 gel for external application to skin for various pains and preparation thereof
The external composition for skin aiming at various pains is a gel-like external composition, and the composition comprises the following components in a weight ratio of 100: 3 parts of arnica extract, 1 part of capsaicin, 1 part of pure CBD powder, 2 parts of camphor and 2 parts of transdermal enhancer, wherein the transdermal enhancer is L40 transdermal agent, 3 parts of auxiliary component and 88 parts of carrier.
The carrier is polymer hydrogel, and the polymer hydrogel is prepared by uniformly mixing sodium carboxymethylcellulose, glycerol, water and alumina in a mass ratio of 10: 30: 40: 0.1. Mixing the above materials, and mixing with polymer hydrogel to obtain gel.
Example 5 high molecular liquid film-forming agent for skin external use for various pains and preparation thereof
The external composition for skin aiming at various pains is a high-molecular liquid film-forming agent for external application, and the liquid external composition comprises the following components in a weight ratio of 100: 2.5 parts of arnica extract, 1 part of capsaicin, 0.5 part of pure CBD powder, 1.5 parts of camphor, 1 part of transdermal enhancer, 2.5 parts of transdermal enhancer of L40, 2.5 parts of auxiliary component and 91 parts of carrier.
The carrier is prepared by uniformly mixing medical acrylic resin, humectant, plasticizer, ethanol, surfactant and purified water in a mass ratio of 20: 5: 2: 62: 1: 10, adding the above components into carrier liquid after uniformly mixing, and stirring to form liquid, thus obtaining the externally applied polymer liquid film-forming agent.

Claims (13)

1. The skin external composition for various pains is characterized by comprising the following components in parts by mass:
Figure FSA0000233755280000011
2. the composition for skin external application aiming at various pains in claim 1, wherein the composition comprises ARNICA MONTANA (ARNICA MONTANA) flower extract.
3. The composition for skin external application aiming at multiple pains is characterized in that a heat-sensing agent is included in the composition, the heat-sensing agent can be one or more of capsaicin, synthetic capsaicin, zingerone, vanillyl butyl ether and the like, and preferably, the heat-sensing agent is capsaicin.
4. The composition for skin external application aiming at various pains is characterized in that one or two combinations of industrial cannabis extract full spectrum CBD oil or pure CBD powder are included in the composition.
5. The composition for skin external application aiming at multiple pains in claim 1 is characterized in that the penetration enhancer is one or a combination of two or more of L40 transdermal agent, azone, volatile oil, 1, 3-dimethyl-2-imidazolidinone, propylene glycol, ethanol and oleic acid, and preferably, the penetration enhancer is L40 transdermal agent.
6. The composition for skin external application aiming at various pains as claimed in claim 1, wherein the composition comprises camphor, which is a grain product obtained by distilling and refining roots, stems, branches and leaves of Cinnamomum camphora (L.) Presl.
7. The full spectrum CBD oil of claim 4, wherein: the Full-Spectrum CBD Oil is a Hemp leaf extract which is extracted from industrial Hemp by organic solvent or supercritical carbon dioxide technology, is not further processed, is rich in active ingredients such as various cannabinoids, flavone, sterol and the like, is often called Full-Spectrum industrial Hemp Oil Full Spectrum Hemp Oil, has the effective ingredient of Cannabidiol (CBD), is a compound naturally existing in industrial Hemp resin flowers, and is a product with the total content of the cannabinoids of 80-90%, the content of the CBD of more than 50% and the content of the THC of less than 0.2%.
8. The pure CBD powder as claimed in claim 4, wherein: english: cannabydiol (translated from Chinese to cannabidiol or cannabidiol, also known as Cannabis sincere feeling) is a pure natural ingredient extracted from industrial cannabis plants. The molecular formula of cannabidiol is C21H 3002. The character is white to light yellow resin or crystal, the melting point is 66-67 ℃, the resin is almost insoluble in water, and the resin is dissolved in organic solvents such as ethanol, methanol, ether, benzene, chloroform and the like. The CBD processed by the nanocrystallization and preparation instant technology becomes a water-soluble CBD product with the characteristics of nano-scale, high content, high solubility, rapid dissolution, wide application, clarification and transparency after water dissolution, and the like, and is a product with the cannabidiol content of more than 99 percent and without THC.
9. The composition for skin external application aiming at various pains in claim 1 is characterized in that the auxiliary ingredients in the composition are composed of part or all of cinnamon, motherwort, argyi leaf, mint, rosemary, basil, grapefruit, chamomile, ruta graveolens, witch hazel (witch hazel) bark/leaf/twig extract, cymbidium hybridum oil, eucalyptus globulus leaf oil, lemon grass seed oil, peppermint oil and rosemary leaf oil.
10. The composition for skin external application aiming at various pains in claim 1 is in the form of liquid, gel, paste, polymer liquid film or patch.
11. The composition for external application to the skin for various pains in accordance with claim 1, wherein: the carrier is one or the combination of more than two of hexadecanol, vaseline, liquid paraffin, glyceryl monostearate, glycerol, ethylparaben, triethanolamine, ethylparaben, lanolin and stearic acid;
or the carrier is selected from one or the combination of more than two of carbomer, polyvinyl alcohol, carboxymethyl cellulose and sodium salt thereof, polyacrylic acid and sodium salt thereof, glycerol and ethanol;
or the carrier is selected from one or the combination of more than two of hot melt pressure-sensitive adhesive, rubber, high polymer hydrogel, medical adhesive tape and acrylate pressure-sensitive adhesive;
or the carrier is one or the combination of more than two of yarns, cotton threads or non-woven fabrics;
or the carrier is selected from one or the combination of more than two of alcoholic solution, ether, ester and vegetable oil;
or the external carrier is selected from a plurality of combinations of medical grade acrylic resin, polyvinyl alcohol, triethanolamine, glycerol, ethanol, EVA, methyl cellulose, plasticizer, purified water and the like.
12. The composition for skin external application aiming at multiple pains in claim 1 is characterized in that the carrier further contains one or more of adhesive, filler, humectant, cross-linking agent, colorant, pH regulator and preservative.
13. The composition for skin external application aiming at various pains in claim 11, wherein the adhesive is selected from one or more of gelatin, sodium alginate, acacia, starch, methylcellulose, carboxymethylcellulose and sodium salts thereof, polyvinyl alcohol, polyethylene glycol, polyvinyl pyrrolidone, carbomer, polyacrylic acid and sodium salts thereof in any combination; the filler is selected from one or more of zinc oxide, micro silica gel powder, calcium carbonate, diatomite and titanium dioxide; the humectant is selected from any one or the combination of more than two of glycerol, propylene glycol, sorbitol and polyethylene glycol; the cross-linking agent is selected from one or the combination of more than two of calcium hydroxide, aluminum trichloride, aluminum glycinate and disodium ethylene diamine tetraacetate.
CN202110188280.3A 2021-02-23 2021-02-23 A topical composition for treating various pains, and its preparation method Pending CN114949120A (en)

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