CN114948337A - Refractive correction implant - Google Patents
Refractive correction implant Download PDFInfo
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- CN114948337A CN114948337A CN202210565896.2A CN202210565896A CN114948337A CN 114948337 A CN114948337 A CN 114948337A CN 202210565896 A CN202210565896 A CN 202210565896A CN 114948337 A CN114948337 A CN 114948337A
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- refractive correction
- lens body
- implant
- cornea
- wall
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/147—Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a refractive correction implant which is used for being implanted into an anterior chamber of a human eye, and comprises a lens main body, a connecting part and a fitting part, wherein the fitting part is used for being adsorbed on the inner wall of the cornea of the human body, the lens main body is used for performing refractive correction on the eye, the lens main body is positioned in the middle of the inner wall of the cornea, a gap is formed between the lens main body and the inner wall of the cornea, the connecting part is positioned between the lens main body and the fitting part and is used for connecting the lens main body and the fitting part, and the connecting part is provided with a through hole for allowing aqueous humor in the anterior chamber to flow. The refractive correction implant can treat refractive ophthalmic diseases including high myopia and the like, does not damage human cornea, and is safe and reliable.
Description
Technical Field
The invention belongs to the field of ophthalmic treatment equipment, and particularly relates to a refractive correction implant.
Background
For patients with refractive eye diseases, the mainstream refractive laser surgery at present belongs to an irreversible treatment scheme, the vision of the patients is changed by carrying out permanent plasticity on the cornea, and only repeated surgery can be carried out to correct the vision along with the change of the symptoms of the ametropia, so that the corneal injury of the patients is large, and the economy is low. At present, the only visual lens ICL product which can realize the reversible ametropia treatment effect in the market is one implanted in the eye, namely, the lens is implanted in the eye through a minimally invasive surgery and is subjected to ametropia correction, although the product cannot damage the cornea, the implantation position of the product is positioned between the crystalline lens and the iris, the space is narrow, and the pupil blockage is very easily caused, so that the glaucoma is caused.
Therefore, it is a technical problem to be solved by those skilled in the art how to perform a continuously effective and safe reversible refractive correction in a patient.
Disclosure of Invention
The invention mainly solves the technical problem of providing a refractive correction implant, and solves the problems of low refractive correction safety and easy glaucoma generation in the prior art.
In order to solve the technical problems, the technical scheme adopted by the invention is to provide a refractive correction implant which is used for being implanted into an anterior chamber of a human eye and comprises a lens main body, a connecting part and a fitting part, wherein the fitting part is used for being adsorbed on the inner wall of the cornea of the human body, the lens main body is used for performing refractive correction on the eye, the lens main body is positioned in the middle position of the inner wall of the cornea, a gap is formed between the lens main body and the inner wall of the cornea, the connecting part is positioned between the lens main body and the fitting part and is used for connecting the lens main body and the fitting part, and a through hole for allowing aqueous humor in the anterior chamber to flow is formed in the connecting part.
Preferably, the lens body has a diameter in the range of 4mm to 10 mm.
Preferably, the lens body has a diameter in the range of 4mm to 7 mm.
Preferably, the lens body has a diameter in the range of 4mm to 5 mm.
Preferably, the gap between the lens body and the inner wall of the cornea is in the range of 0.5mm to 1.5 mm.
Preferably, the upper surface of the lens body is convex or concave and the lower surface of the lens body is convex or concave.
Preferably, the perforations are evenly arranged around the connection.
Preferably, the perforations are circular or arc-shaped or elongated.
Preferably, the outermost edge of the conformable portion is spaced from the outermost edge of the inner corneal wall.
Preferably, the material of the refractive correction implant is a collagen polymer or a silica gel or an acrylic or hydrogel.
The invention has the beneficial effects that: the invention discloses a refractive correction implant which is used for being implanted into an anterior chamber of a human eye, and comprises a lens main body, a connecting part and a fitting part, wherein the fitting part is used for being adsorbed on the inner wall of the cornea of the human body, the lens main body is used for performing refractive correction on the eye, the lens main body is positioned in the middle of the inner wall of the cornea, a gap is formed between the lens main body and the inner wall of the cornea, the connecting part is positioned between the lens main body and the fitting part and is used for connecting the lens main body and the fitting part, and the connecting part is provided with a through hole for allowing aqueous humor in the anterior chamber to flow. The refractive correction implant can treat refractive ophthalmic diseases including high myopia, etc., and has no damage to cornea, high safety and high reliability.
Drawings
FIG. 1 is a schematic view of one embodiment of a refractive correction implant of the present invention;
FIG. 2 is a schematic top view of the embodiment of FIG. 1 (shielding cornea);
FIG. 3 is a schematic view of another embodiment of a refractive correction implant of the present invention;
fig. 4 is a schematic top view of the embodiment shown in fig. 3 (shielding cornea).
Detailed Description
In order to facilitate an understanding of the invention, the invention is described in more detail below with reference to the accompanying drawings and specific examples. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It is to be noted that, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
Description of the drawings: the arrows in the figure indicate the direction of the flow of the room water.
With reference to fig. 1 and 2, the refractive correction implant is used for implanting into the anterior chamber 4 of a human eye, and in actual operation, the refractive correction implant is implanted between the cornea 5 and the iris 6 of a patient through a minimally invasive surgery, namely, the refractive correction implant is implanted into the anterior chamber 4 of the patient eye through the limbus 7, and after being unfolded in the anterior chamber 4, the refractive correction implant is adsorbed on the inner wall 51 of the cornea, and the lens part (i.e. the lens body 1) of the refractive correction implant improves the performance of the patient refractive optical system to achieve the purpose of refractive correction, and the diopter of the lens body 1 is customized according to the vision condition of the patient to ensure the accuracy of the refractive correction.
Preferably, the refractive correction implant comprises a lens body 1, a connecting part 2 and a joint part 3, the joint part 3 is used for being attached to the inner corneal wall 51 of the human body, the lens body 1 is used for performing refractive correction on the eye, the lens body 1 is located at the middle position of the inner corneal wall 51, namely, the lens body 1 covers most of the central visual field of the patient to ensure the effect of the refractive correction, a gap is formed between the lens body 1 and the inner corneal wall 51, so that aqueous humor can enter the gap between the refractive correction implant and the inner corneal wall 51 to provide oxygen and nutrition for endothelial cells at the middle position of the cornea, the normal survival and work of the endothelial cells at the center of the cornea are maintained, the connecting part 2 is located between the lens body 1 and the joint part 3 and is used for connecting the lens body 1 and the joint part 3, the joint part 3 is tightly jointed with the inner corneal wall 51 to provide structural support for the implant, the lens body 1 is firmly fixed in the anterior chamber 4 due to the adsorption effect of the attaching part 3, so that the relative stability of the middle position of the lens body and the inner wall 51 of the cornea is maintained, the accuracy of the refractive correction is guaranteed, the connecting part 2 is provided with the through hole 21 for the circulation of the aqueous humor in the anterior chamber 4, the aqueous humor can flow to the gap between the lens body 1 and the inner wall 51 of the cornea through the through hole 21, and oxygen and nutrition are provided for the corneal endothelial cells.
Preferably, the thickness of the lens body 1 is in the range of 100 microns to 4 millimeters, more preferably, the thickness of the lens body 1 is in the range of 100 microns to 1 millimeter, more preferably, the thickness of the lens body 1 is in the range of 100 microns to 700 microns.
Preferably, the thickness of the lens body 1 is in the range of 700 microns to 3mm, and more preferably, the thickness of the lens body 1 is in the range of 700 microns to 1 mm.
Preferably, the diameter of the lens body 1 ranges from 4mm to 10mm, ensuring that the lens body can completely cover the central zone of the cornea, in order to guarantee the effect of the refractive correction.
It is further preferred that the diameter of the lens body 1 is in the range of 4mm to 7 mm.
It is further preferred that the diameter of the lens body 1 is in the range of 4mm to 5 mm.
Preferably, the width of the bonded portion 3 is in the range of 1mm to 5mm, and more preferably, the width of the bonded portion 3 is in the range of 1mm to 3 mm.
Preferably, the gap X1 between the lens body 1 and the inner corneal wall 51 is in the range of 0.5mm to 1.5mm, which ensures that a gap is left for the circulation of aqueous humor to deliver nutrients and oxygen, and that the gap is not too large to ensure the refractive correction effect.
Preferably, the upper surface of the lens body 1 is a convex surface or a concave surface, the lower surface of the lens body 1 is a convex surface or a concave surface, the curvatures of the upper surface and the lower surface of the lens body 1 are designed according to the requirements of refractive correction, and the thickness of the lens body 1 is designed according to the diopter of a patient, which is not described herein again.
Preferably, the perforations 21 are uniformly arranged around the connecting portion 2 to ensure that the aqueous humor uniformly flows into the gap between the lens body 1 and the inner corneal wall 51, so that oxygen and nutrients can be uniformly and rapidly delivered to corneal endothelial cells, and the circulation of the aqueous humor can be ensured to be performed normally.
Preferably, the perforations 21 are circular or arc-shaped or elongated.
Preferably, the outermost edge of the flap 3 has a distance X2 from the outermost edge of the inner corneal wall 51, i.e. the flap 3 does not completely cover the outermost edge of the inner corneal wall 51, in order to leave room for the subsequent surgical operation to operate, while protecting the trabecular meshwork at the location of the limbus 7 and preventing the flap 3 from being worn down to the trabecular meshwork.
The corneal endothelial cells are mainly divided into corneal central endothelial cells and corneal peripheral endothelial cells, the corneal central endothelial cells are mainly supplied by aqueous humor, the corneal peripheral endothelial cells are mainly supplied by corneal limbus, the attaching part 3 is mainly attached to the corneal limbus, and the attaching part 3 does not affect the oxygen supply and metabolism of the corneal endothelial cells.
The connecting part 2 is connected with the lens main body 1 and the fitting part 3, and the transition is smooth on the whole, namely the refractive correction implant (implant for short) adopts a smooth optical transition design on the whole, and the lens main body 1 is subjected to optical design according to the vision condition and the requirement of a patient and the angle and the relative position between the lens main body 1 and the cornea 5 so as to achieve specific diopter, realize the purpose of refractive correction and restore the smooth visual field for the patient.
Preferably, the material of the refractive correction implant is collagen polymer or silica gel or acrylic acid or hydrogel, so that safety and no stimulation are guaranteed, the implant (namely the lens main body 1, the connecting part 2 and the attaching part 3 are mutually compatible) has good biocompatibility, and has excellent optical characteristics, meanwhile, the material of the implant also has flexible and foldable performance, can be automatically unfolded after being implanted into eyes in a folded state, and can also be smoothly folded and taken out again, the implant does not adhere to intraocular tissues (such as an anterior chamber, a cornea or an iris) and does not form scars, the material of the implant also has the characteristics of high oxygen permeability and the like, the nutrition supply of the cornea can be guaranteed, and the normal metabolic function of the cornea can be maintained.
Specifically, the attaching portion 3 has high oxygen permeability, and even if the attaching portion 3 is attached to the endothelial cells of the corneal inner wall 51, normal nutrition and oxygen absorption of the endothelial cells are not affected, and the endothelial cells of the cornea can be ensured to maintain original cell characteristics and functions.
Preferably, with reference to fig. 3 and 4, in another embodiment, the refractive correction implant (simply referred to as an implant) comprises a lens body a1 and a fitting part a2, the lens body a1 is connected with the fitting part a2, the lens body a1 is used for fitting the middle position of the inner corneal wall a31 of the intraocular cornea A3 and forming an aqueous humor barrier, the lens body a1 is used for performing refractive correction on the eye, the fitting part a2 is used for being adsorbed and fitted at the peripheral position of the inner corneal wall a31, for a patient whose cornea A3 is damaged or partially damaged and is accompanied by ametropia disease, the implant is implanted between the iris a4 and the cornea A3 of the patient by a minimally invasive surgery (the implant is implanted through the corneal limbus A6), the implant gradually expands in the intraocular cornea a5 and is adsorbed and fitted to the inner corneal wall a31 of the cornea A3, so as to replace or partially replace corneal endothelial cells, on one hand, the corneal-aqueous humor-endothelial barrier is formed by replacing corneal cells, treating diseases related to the corneal lesion, and treating refractive ophthalmic diseases including high myopia and the like through the lens body A1 of the implant after optical design.
During actual operation, the implant is implanted into the anterior chamber A5 of the eye of a patient through the limbus A6, after the implant is completely adsorbed on the inner wall A31 of the cornea after the anterior chamber A5 is unfolded, the diopter of the lens body A1 of the implant is subjected to customized optical design according to the vision condition of the patient, the performance of a dioptric system of the patient can be obviously improved, and the aim of dioptric correction is fulfilled.
Preferably, the implant is made of a material having good biocompatibility and excellent optical characteristics; the implant material also has flexible and foldable performance, can realize automatic and complete unfolding after being implanted in a folded state, can be smoothly folded again and taken out from the corneal limbus A6, and does not cause tissue adhesion and scar formation. The material of the implant also has the characteristics of high oxygen permeability and the like, can ensure the nutrient supply of the cornea A3 and maintain the normal metabolic function of the cornea A3.
Specifically, the lens body A1 of the implant is completely attached to the inner corneal wall A31, which can play a role of a cornea-aqueous humor barrier, replace an already-diseased endothelial layer (namely, an endothelial cell layer of the cornea), prevent liquid from transferring to a corneal central stroma layer, and relieve corneal diseases such as corneal edema.
The implant is designed to have smooth optical transition as a whole, and the central lens body A1 is designed optically according to the vision condition and requirements of the patient to achieve a specific diopter to achieve the purpose of refractive correction and restore a smooth high quality vision level for the patient.
The lens body a1 of the implant covers a substantial portion of the patient's central visual field to ensure the effect of the refractive correction.
The attaching part A2 is smoothly connected with the lens main body A1, and is adsorbed on the inner corneal wall A31 and the periphery thereof after the implant is implanted and unfolded.
No additional adhesion layer is needed between the implant and the inner corneal wall A31 to improve the adsorption effect of the implant and the cornea A3, and the support of the implant can be realized.
Preferably, the outermost edge of flap a2 is spaced a distance L1 from the outermost edge of inner corneal wall a31, i.e., flap a2 does not completely cover the outermost edge of inner corneal wall a31, which allows room for subsequent surgical procedures to be performed while protecting the trabecular meshwork at the location of limbus a6 and preventing flap 3 from fraying to the trabecular meshwork.
Preferably, the width of the attaching part a2 ranges from 1mm to 5mm, more preferably, the width of the attaching part a2 ranges from 1mm to 4mm, and more preferably, the width of the attaching part a2 ranges from 1mm to 3 mm.
Preferably, the diameter of lens body A1 ranges from 4mm to 10 mm.
It is further preferred that the diameter of the lens body A1 be in the range of 4mm to 7 mm.
It is further preferred that the diameter of lens body A1 be in the range of 4mm to 5 mm.
Preferably, the upper surface of the lens body a1 fits against the inner corneal wall a31, the lower surface of the lens body a1 is convex or concave, the curvatures of the upper and lower surfaces of the lens body a1 are designed according to the refractive correction requirements, and the thickness of the lens body a1 is designed according to the diopter of the patient, which will not be described herein again.
Preferably, the attaching part A2 is attached to the inner wall A31 of the cornea through electrostatic attraction or degradable biological adhesive, so that the cornea attaching device is more environment-friendly and safer, has stable property and does not bring side effects to patients.
Preferably, the material of the refractive correction implant is a collagen polymer or a silica gel or an acrylic acid or a hydrogel, which is safer and non-irritating to the patient.
Based on the embodiment, the invention discloses a refractive correction implant which is used for being implanted into an anterior chamber of a human eye, and comprises a lens main body, a connecting part and a fitting part, wherein the fitting part is used for being adsorbed on the inner wall of the cornea of the human body, the lens main body is used for performing refractive correction on the eye, the lens main body is positioned in the middle position of the inner wall of the cornea, a gap is formed between the lens main body and the inner wall of the cornea, the connecting part is positioned between the lens main body and the fitting part and is used for connecting the lens main body and the fitting part, and a through hole for allowing aqueous humor in the anterior chamber to flow is formed in the connecting part. The refractive correction implant can treat refractive ophthalmic diseases including high myopia and the like, does not damage human cornea, and is safe and reliable.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent structural changes made by using the contents of the present specification and the drawings, or applied directly or indirectly to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. A refractive correction implant for implantation in the anterior chamber of a human eye, comprising a lens body, a connecting portion and a fitting portion, wherein the fitting portion is used for being attached to the inner wall of the cornea of the human body, the lens body is used for performing refractive correction on the eye, the lens body is located in the middle of the inner wall of the cornea, a gap is formed between the lens body and the inner wall of the cornea, the connecting portion is located between the lens body and the fitting portion and is used for connecting the lens body and the fitting portion, and a through hole for flowing of aqueous humor in the anterior chamber is formed in the connecting portion.
2. A refractive correction implant as claimed in claim 1, wherein the lens body has a diameter in the range of 4mm to 10 mm.
3. A refractive correction implant as claimed in claim 2, wherein the lens body has a diameter in the range of 4mm to 7 mm.
4. A refractive correction implant as claimed in claim 3, wherein the lens body has a diameter in the range of 4mm to 5 mm.
5. A refractive correction implant as claimed in any one of claims 1 to 4, wherein the gap between the lens body and the inner corneal wall is in the range 0.5mm to 1.5 mm.
6. A refractive correction implant as claimed in claim 5, wherein the upper surface of the lens body is convex or concave and the lower surface of the lens body is convex or concave.
7. A refractive correction implant as claimed in claim 6, wherein the perforations are evenly disposed around the connecting portion.
8. A refractive correction implant as claimed in claim 7, wherein the perforations are circular or arc or elongate.
9. A refractive correction implant as recited in claim 8, wherein the abutment has a distance between an outermost edge and an outermost edge of the inner corneal wall.
10. A refractive correction implant as claimed in claim 9, wherein the material of the refractive correction implant is a collagen polymer or a silica gel or an acrylic acid or a hydrogel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210565896.2A CN114948337A (en) | 2022-05-23 | 2022-05-23 | Refractive correction implant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210565896.2A CN114948337A (en) | 2022-05-23 | 2022-05-23 | Refractive correction implant |
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| Publication Number | Publication Date |
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| CN114948337A true CN114948337A (en) | 2022-08-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210565896.2A Pending CN114948337A (en) | 2022-05-23 | 2022-05-23 | Refractive correction implant |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023226471A1 (en) * | 2022-05-23 | 2023-11-30 | 苏州朗目医疗科技有限公司 | Refractive correction implant |
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2022
- 2022-05-23 CN CN202210565896.2A patent/CN114948337A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023226471A1 (en) * | 2022-05-23 | 2023-11-30 | 苏州朗目医疗科技有限公司 | Refractive correction implant |
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