CN114948033A

CN114948033A - Skin anastomat

Info

Publication number: CN114948033A
Application number: CN202210505307.1A
Authority: CN
Inventors: 张利东
Original assignee: East China Normal University
Current assignee: East China Normal University
Priority date: 2022-05-10
Filing date: 2022-05-10
Publication date: 2022-08-30

Abstract

Embodiments of the present application relate to skin staplers. According to some embodiments of the present application, a skin stapler comprises: the fixing component comprises a first chain for zipper connection at one end and is fixed at one side of a part to be anastomosed of the skin at the other end; and an intermediate member for being disposed over the site to be anastomosed by the fixation assembly. Embodiments of the present application also provide a method for treating a skin wound comprising using the aforementioned skin stapler. The skin anastomat provided by the embodiment of the application can effectively solve the problems in the traditional technology.

Description

Skin anastomat

Technical Field

The embodiments of the present application relate generally to the field of medical technology, and more particularly, to a skin stapler.

Background

The traditional method for treating the wound comprises the step of tightening the skin on two sides of the wound by using a plurality of traction assemblies, so that secondary injury to the wound caused by friction of the assemblies cannot be avoided, and the wound cannot be better protected or treated.

Accordingly, the present application provides a skin stapler.

Disclosure of Invention

It is an object of embodiments of the present application to provide a skin stapler that can effectively protect or treat a wound at a site to be anastomosed, compared to conventional methods.

The embodiment of the application provides a skin anastomat, which includes: the fixing component comprises a first chain for zipper connection at one end and is fixed at one side of the skin to-be-anastomosed part at the other end; and an intermediate member for being disposed over the site to be anastomosed by the fixation assembly.

According to some embodiments of the application, at least one end of the intermediate member is connected to one end of the fixation assembly.

According to some embodiments of the application, the intermediate element comprises a second chain for zip-like connection with the fixing assembly.

According to some embodiments of the application, at least a portion of the intermediate member is removable.

According to some embodiments of the application, the intermediate component comprises an active layer.

According to some embodiments of the present application, the active layer includes a substrate and a gel layer positioned over the substrate.

According to some embodiments of the present application, the gel layer comprises a drug.

According to some embodiments of the application, the surface of the stapler comprises at least one of the following figures: polygonal, circular and irregular patterns.

Another embodiment of the present application also provides a method for treating a skin wound comprising using the aforementioned stapler.

According to still further embodiments of the present application, the method further comprises: fixing the fixing component around the skin wound; and performing zipper-type connection on the fixing assemblies.

Still another embodiment of the present application provides a skin stapler, which includes two fixing members for being disposed at both sides of a portion to be anastomosed, wherein one end of the fixing member includes a chain for zipper-type connection, and the other end is used for disposing the fixing member at one side of the portion to be anastomosed, and the two fixing members can be zipper-type connected through each other chain to form protection to the portion to be anastomosed.

Compared with the prior art, the skin anastomat provided by the embodiment of the application can effectively protect or treat the wound of the part to be anastomosed.

Drawings

Drawings necessary for describing embodiments of the present application or the prior art will be briefly described below in order to describe the embodiments of the present application. It is to be understood that the drawings in the following description are only some of the embodiments of the present application. It will be apparent to those skilled in the art that other embodiments of the drawings can be obtained from the structures illustrated in these drawings without the need for inventive work.

FIG. 1 is a diagram of a skin stapler 100 according to some embodiments of the present application.

FIG. 2 illustrates a skin stapler 200 according to further embodiments of the present application.

FIG. 3 illustrates a skin stapler 300 according to further embodiments of the present application.

FIG. 4 illustrates a skin stapler 300 after zipper-type attachment according to further embodiments of the present application.

FIG. 5 illustrates a circular stapler 400 according to further embodiments of the present application.

FIG. 6 illustrates a skin stapler 500 according to further embodiments of the present application.

Detailed Description

In order to better understand the spirit of the embodiments of the present application, the following further description is given in conjunction with some preferred embodiments of the present application.

Embodiments of the present application will be described in detail below. Throughout the specification, the same or similar components and components having the same or similar functions are denoted by like reference numerals. The embodiments described herein with respect to the figures are illustrative in nature, are diagrammatic in nature, and are used to provide a basic understanding of the present application. The embodiments of the present application should not be construed as limiting the present application.

For convenience of description, "first," "second," and the like may be used herein to distinguish one element or series of elements from another. "first," "second," and the like are not intended to describe corresponding components or operations.

The skin anastomat provided by the application can conveniently and effectively protect the wound on the skin.

The skin anastomat 100 comprises a fixing component 20, wherein one end 2 of the fixing component 20 comprises a first chain 31 for zipper connection, and the other end 5 is used for fixing the fixing component 20 on one side of a part to be anastomosed of the skin; and an intermediate member 10 for being positioned over a site to be anastomosed (not shown in the figures) by a fixation assembly 20 to protect a wound of the site to be anastomosed.

The intermediate member 10 may also be the one shown in fig. 2, the intermediate member 10 may be located below the fixing assembly 20, and at least one end thereof may be connected to one end 2 of the fixing assembly 20, so that the intermediate member 10 may be placed above the portion to be anastomosed by the fixing assembly 20, wherein the length of the intermediate member 10 may be adjusted, and the size of the fixing assembly and the intermediate member may be set according to the area size of the portion to be anastomosed.

According to some embodiments of the present application, the securing assembly may include a film layer and a substrate layer, for example, the securing assembly may be secured by the flexible film layer and the substrate layer by a waterproof bioadhesive bond. The substrate and the first chain of the fixing component can be fixed by waterproof biological glue or assembled by sewing with needles and threads.

The film layer can be made of a high molecular film such as Polydimethylsiloxane (PDMS), polyvinylidene fluoride (PVDF) or Polytetrafluoroethylene (PTFE), an inorganic material such as carbon fiber or a metal material such as membrane materials of aluminum, iron, copper and the like, and the substrate layer can be made of a high molecular polymer such as Polytetrafluoroethylene (PTFE), nylon and the like, such as commercial non-elastic sand-eye cloth.

For example, a PDMS film may be adhered to a gauze surface to make a fixed assembly. A skin stapler of a suitable size may be prepared according to the size of the area of the site to be anastomosed, for example, by adhering a PDMS film to the surface of a gauze (e.g., a commercial non-elastic gauze) having a larger area using bio-waterproof glue, and aligning the PDMS film with one side of the gauze and an extra portion of the other side of the gauze for mounting a first chain. For example, the PDMS film may have dimensions of about 60 mm by 30 mm by 100 μm, and the gauze may have dimensions of about 60 mm by 40 mm by 0.5 mm. As shown in fig. 1, the first chain 31 is adhered to one end 2 of the gauze by bio-waterproof glue, so as to obtain the desired fixing assembly 20.

According to some embodiments of the present application, the skin stapler proposed in the present application can be obtained by uniformly coating a layer of desensitizing adhesive on the surface of the fixing member (e.g. PDMS film) and tightly covering the desensitizing adhesive with a non-stick adhesive paper.

According to some embodiments of the application, the intermediate element may comprise a second chain for zip-like connection with the fixing assembly. As shown in fig. 3, one end 12 of the intermediate element 10 may also include a second stringer 3 for zip-like connection with a securing assembly 20.

The skin anastomat 300 provided by the application can be used for the surface of a skin wound, for example, the two ends of the fixing component 20 are attached to the skin on the two sides of the wound, the wound can be promoted to be anastomosed and the wound can be protected only by slightly pulling the zipper type chain, and the injury possibly brought by the outside can be effectively avoided. As shown in fig. 4, the fixing assembly 20 and the intermediate member 10 may be zipper-connected by the slider 4, thereby placing the intermediate member 10 on the skin at the site to be anastomosed.

Because the middle part is connected with the fixed assembly through the zipper type structure, and can be conveniently disassembled, at least one part or all of the middle part can be replaced according to actual requirements.

The zipper type zipper chain (the first zipper chain 31 or the second zipper chain 3) or the slider can be made of metal, such as gold, silver, copper and the like, or polymer plastic or alloy material.

As shown in fig. 4, the intermediate member 10 may be attached thereto by a fastening assembly 20 for positioning over the site to be anastomosed.

According to some embodiments of the present application, as shown in fig. 3, the middle member 10 may include an action layer 1 to suture or treat an anastomosis site. For example, the active layer 1 may include a substrate and a gel layer disposed over the substrate.

Wherein the gel layer can be hydrogel, ionic gel or organic gel, and the gel material can be natural gel or synthetic gel. The substrate may be gauze, such as commercial non-elastic gauze, and may be made from high molecular weight polymers such as Polytetrafluoroethylene (PTFE), nylon, and the like.

The skin anastomat provided by the application can be designed according to the area of the part to be anastomosed. For example, the size of the gel layer of the intermediate member 10: length: 10-1000 mm, width: 10-100 mm, thickness: 0.1-10 mm; size of the substrate: length: 10-1000 mm, width: 20-120 mm, thickness: 0.1-1 mm.

The surface of the anastomat provided by the application can be arranged into at least one of the following figures according to the shape of the part to be anastomosed: polygonal, circular and irregular patterns, such as triangular, square, etc. As shown in fig. 1-3, the anastomat is rectangular and is suitable for the anastomosis, protection and treatment of long-strip or linear damaged wounds on the surface of the skin.

Another embodiment of the present application also provides a circular stapler for protecting or treating a near-circular wound. As shown in fig. 5, the skin stapler 400 includes a fixing member 20, one end 2 of the fixing member 20 includes a first chain 31 for zipper-type connection, and the other end 5 is for fixing the fixing member to one side of a site to be anastomosed of the skin; and a circular middle member 10 for being positioned over a site to be anastomosed by a fixation assembly 20. The edge of the middle part 10 can be provided with a second zipper 3 to be connected with the fixing component 20 through a zipper 4 by the first zipper 31, so as to protect the part to be anastomosed below the middle part 10. The active layer 1 may include a base and a gel layer over the base, which may contain a drug to protect, suture, and treat a wound thereunder.

According to some embodiments of the present application, the preparation of the gel layer may be made by:

s1: weighing a proper weight of materials for preparing the gel layer, such as 2 g of acrylamide, 0.001 g N, N' -methylene bisacrylamide, 0.9 g of methacryloxypropyltrimethylammonium chloride, 0.02 g of ammonium persulfate and 10mL of deionized water, adding the materials into a 20mL beaker, and stirring the materials in the beaker in dark until the materials are dissolved uniformly, wherein drugs can be added into the gel layer according to requirements, such as 0.1g of penicillin sodium salt can be added into the 20mL beaker and stirring is carried out;

s2: taking two cleaned glass slides, cutting a silica gel sheet with the thickness of about 1mm into the size of the glass slide, and covering one of the glass slides;

s3: cutting off the middle part of the silica gel sheet, leaving a blank area with the area of 60 mm x 30 mm, covering the other clean glass slide with the silica gel sheet to form a glass slide/silica gel sheet/glass slide sandwich structure device with aligned edges, and compacting to ensure that the glass slide is tightly combined with the silica gel gasket without leakage;

s4: extracting air in the sandwich structure device by using an injector, and injecting argon;

s5: and injecting the stirred solution into a mold by using a dropper, slightly covering a glass slide on the surface of the mold filled with the solution, and transferring to an ultraviolet lamp to irradiate for 30 min to prepare the polyacrylamide hydrogel sheet with the size of 60 mm 30 mm 1 mm.

According to other embodiments of the present application, the gel sheet was adhered to a commercial non-elastic scrim surface having dimensions of about 60 mm by 50 mm by 0.5 mm using a bio-waterproof adhesive, as shown in fig. 1. And adhering the chains to two edges of the non-elastic sand-eye cloth by using biological waterproof glue to obtain a required middle part, wherein the surface of the hydrogel is covered by non-stick adhesive paper to prevent water loss.

The gel layer and the base of the middle part can be fixed by waterproof biological adhesive, and the base and the chain can be fixed by waterproof biological adhesive or assembled and fixed by sewing with needles and threads.

According to some embodiments of the present application, the gel layer may include a drug, and a large amount of organic cationic groups may be added during the preparation of the gel layer, so that the intermediate member has excellent effects of sterilization and wound healing promotion.

The skin anastomat provided by the application can be used for appropriately protecting and treating wounds, and for example, injuries caused by surgical suture can be effectively avoided. The fixing component is connected with the zipper in the middle part, so that the use is convenient, the two sides of the wound can be tightened, and the healing of the wound is promoted; arranging a gel layer in the middle part to enable the wound at the position to be anastomosed to be treated; in particular, the gel layer can be loaded with drugs, effective treatment on wounds is realized through slow drug release, and the moist hydrogel layer is also beneficial to healing of the wounds, and is particularly suitable for protecting and treating large wounds caused by operations, such as postoperative wounds of caesarean section, heart bypass and the like.

Further embodiments of the present application also provide a method for treating a skin wound comprising using the skin stapler described above.

The method may further comprise securing the fixation assembly around the skin wound; and a schematic view of the fastener assembly being connected by a zipper, as shown in fig. 4, after the fastener assembly 20 and the intermediate member 10 are connected by a chain at both ends of each other.

For example, when the skin stapler 300 is used, after the non-stick adhesive paper on the surface (e.g., the surface of the gel layer and the PDMS film) of the middle part 10 and the fixing assembly 20 is torn off, the two ends of the fixing assembly 20 are tightly adhered to the two sides of the wound, the first chain 31 of the fixing assembly 20 and the second chain 3 of the middle part 10 are connected by the zipper 4, the wound is pulled to be anastomosed, the active layer 1 (e.g., the gel layer under the substrate) can be spontaneously attached to the surface of the wound to play roles of protecting the wound, absorbing the exudate of the tissue and sterilizing, thereby promoting the wound healing, and when a drug, such as penicillin sodium salt, is added into the gel layer, the drug can slowly enter the wound area to achieve the effects of diminishing inflammation and promoting the wound healing.

As shown in fig. 6, the skin stapler 500 may include two fixing members 20 for being disposed at both sides of a site to be anastomosed, wherein one end of the fixing member 20 includes a chain 31 for zipper-type connection and the other end is for disposing the fixing member 20 at one side of the site to be anastomosed, and the two fixing members 20 may be zipper-type connected by the chain 31 to each other to form protection to the site to be anastomosed.

After a layer of desensitizing adhesive is uniformly coated on the surface of the fixing component (e.g., PDMS film) and tightly covered with a non-stick adhesive paper, the skin stapler 500 proposed in the present application can be obtained.

According to some embodiments of the present application, an intermediate member may be disposed below the chain such that at least one end of the intermediate member is connected to one end of the fixing assembly, or both ends of the intermediate member are respectively connected to one end of each fixing assembly, thereby protecting a portion to be anastomosed located below through the intermediate member.

According to the aforementioned embodiments, the intermediate member may also be configured to include an active layer for suturing, protecting or treating the site to be anastomosed.

The skin anastomat provided by the application can be used for protecting, suturing and/or treating wounds, is convenient and easy to use, and can quickly promote the healing of the wounds of the parts to be anastomosed.

The technical content and technical features of the present application have been disclosed as above, however, those skilled in the art may still make various substitutions and modifications based on the teaching and disclosure of the present application without departing from the spirit of the present application. Therefore, the protection scope of the present application should not be limited to the disclosure of the embodiments, but should include various alternatives and modifications without departing from the scope of the present application, which are encompassed by the claims of the present patent application.

Claims

1. A skin stapler, comprising:

the fixing component comprises a first chain for zipper connection at one end and is fixed at one side of a part to be anastomosed of the skin at the other end; and

an intermediate member for placement over the site to be anastomosed by the fixation assembly.

2. The stapler of claim 1, wherein at least one end of the intermediate member is coupled to one end of the fastening assembly.

3. The stapler of claim 1, the intermediate member including a second chain for zippering with the securing assembly.

4. The stapler of claim 1, wherein at least a portion of the intermediate member is removable.

5. The stapler of claim 1, wherein the intermediate member includes an active layer.

6. The stapler of claim 5, wherein the active layer includes a base and a gel layer positioned over the base.

7. The stapler of claim 4, the gel layer comprising a medicament.

8. The stapler of claim 1, wherein a surface of the stapler comprises at least one of the following graphics: polygonal, circular and irregular patterns.

9. A method for treating a skin wound comprising using the stapler of any one of the preceding claims 1-8.

10. The method of claim 9, further comprising: securing the fixation assembly around the skin wound; and performing zipper-type connection on the fixing assembly.

11. A skin stapler comprising two fixing members for being disposed at both sides of a site to be anastomosed, wherein one end of the fixing members comprises a chain for zipper-type connection and the other end is for being disposed at one side of the site to be anastomosed, the two fixing members being zipper-type connected by the chain to each other to form protection of the site to be anastomosed.