CN114927232B - Drug research and development type mining and searching method and device and electronic equipment - Google Patents
Drug research and development type mining and searching method and device and electronic equipment Download PDFInfo
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Abstract
The invention provides a drug research and development type mining and searching method, a device and electronic equipment, wherein the mining method comprises the following steps: acquiring target points, action mechanisms, research and development stages and research and development milestone dates corresponding to the medicines; clustering the medicines based on the target points and the action mechanism to obtain a plurality of medicine sets; determining a research and development type label of each medicine in each medicine set based on the highest research and development stage in the research and development stage corresponding to each medicine in each medicine set and the research and development milestone date corresponding to the highest research and development stage. The medicine research and development type mining and searching method, the medicine research and development type searching device and the electronic equipment provided by the embodiment of the invention can accurately and clearly define the research and development types of the medicines and mark the research and development types in a label form, so that the comprehensive and reliable medicine research and development type mining is realized, and the obtained research and development types of the medicines provide convenience for searching the medicines with advanced innovation.
Description
Technical Field
The invention relates to the technical field of computers, in particular to a medicine research and development type mining and searching method, a medicine research and development type mining and searching device and electronic equipment.
Background
The type of drug development may characterize the degree of innovation of the drug. For the definition of innovative drugs, taking chemical drugs as an example, the new drugs of class 1.1 are generally referred to in the past. However, the new drug class 1.1 is not necessarily a truly innovative drug, and is likely to be a drug with a brand new structure and a same target point following the development of other enterprises.
Currently, the pharmaceutical industry generally defines some informal definitions for drugs, such as FIC (first in class), fast follow, me too, BIC (best in class), or me beter. However, these definitions do not have a standard and the knowledge of these definitions within the industry is not consistent, resulting in the inability of the user to quickly locate truly innovative drugs.
Therefore, it is a problem that needs to be solved to help users to efficiently find innovative and leading medicines from a large amount of medicines.
Disclosure of Invention
The invention provides a medicine research and development type mining and searching method, a device and electronic equipment, which are used for solving the defect that a user cannot quickly locate a truly innovative medicine in the prior art.
The invention provides a drug development type mining method, which comprises the following steps:
acquiring target points, action mechanisms, research and development stages and research and development milestone dates corresponding to the medicines;
clustering the medicines based on the target points and the action mechanism to obtain a plurality of medicine sets;
determining a research and development type label of each medicine in each medicine set based on the highest research and development stage in the research and development stage corresponding to each medicine in each medicine set and the research and development milestone date corresponding to the highest research and development stage.
According to the drug development type mining method provided by the invention, the determining of the development type label of each drug in each drug set based on the highest development stage in the development stages corresponding to each drug in each drug set and the development milestone date corresponding to the highest development stage comprises the following steps:
based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the sequence of the research and development milestone date corresponding to the highest research and development stage from front to back, the medicines in the medicine sets are sequenced, and the research and development type labels of the medicines in the medicine sets are determined.
According to the drug development type mining method provided by the invention, the drugs in the drug collections are sorted based on the highest development stage in the development stages corresponding to the drugs in the drug collections and the sequence of development milestone dates corresponding to the highest development stage from front to back, and the development type labels of the drugs in the drug collections are determined, and the method comprises the following steps:
determining that the research and development type label of the earliest approved medicine on the market in each medicine set is 1st IC based on the date corresponding to the approval on the market when the highest research and development stage in the research and development stages corresponding to each medicine in each medicine set is approved to be on the market;
sequencing the other medicines based on the sequence of development milestone dates corresponding to the highest development stages of the other medicines from front to back, and determining development type labels of the folow types of the other medicines, wherein the other medicines are medicines in the medicine sets except the medicine which is approved to be listed earliest;
and under the condition that the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets does not comprise approval for marketing, sequencing the medicines in the medicine sets based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the sequence of the development milestone date corresponding to the highest research and development stage from front to back, and determining the research and development type labels of the IC types of the medicines in the medicine sets.
According to the drug development type mining method provided by the present invention, the drugs in each drug collection are ranked based on the highest development stage in the development stages corresponding to the drugs in each drug collection and the order of the development milestone date corresponding to the highest development stage from front to back, and the development type label of each drug in each drug collection is determined, further comprising:
in case the indication of any drug is related to a breakthrough therapy, the development type label BIC is added to the development type label of said any drug.
According to the drug development type mining method provided by the present invention, the method for mining a drug development type determines a development type label of each drug in each drug set based on a highest development stage in development stages corresponding to each drug in each drug set and a development milestone date corresponding to the highest development stage, and then further includes:
and under the condition that the action mechanisms of the medicine sets are the same, the number of the target points is the same, and the relationship between any target point in each medicine set and any target point in other medicine sets meets a preset target point level map, performing research and development type label adjustment based on the highest research and development stage and the target point corresponding to the medicine with the research and development type label of 1st IC in each medicine set.
According to the medicine development type mining method provided by the invention, the development milestone date corresponding to each medicine is determined based on the following steps:
determining a development milestone date corresponding to each medicine based on the medicine name, the development mechanism and the development progress corresponding start time of each medicine;
the development progress corresponding start time includes at least one of an approval time to market, an application time to market, a start time of each clinical development stage, an approval clinical time, and an application clinical time.
The invention also provides a retrieval method, which comprises the following steps:
receiving a target research and development type label sent by a user terminal;
screening out the medicines corresponding to the target research and development type labels from the predetermined research and development type labels of the medicines, and returning information associated with the medicines to the user terminal; the development type label of each drug is determined based on the drug development type mining method as described above.
The invention also provides a drug research and development type mining device, which comprises an information acquisition unit, a drug clustering unit and a research and development type determination unit, wherein:
the information acquisition unit is used for acquiring target points, action mechanisms, research and development stages and research and development milestone dates corresponding to the medicines;
the medicine clustering unit is used for clustering the medicines based on the target points and the action mechanism to obtain a plurality of medicine sets;
the research and development type determining unit is used for determining the research and development type labels of the medicines in the medicine sets based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the research and development milestone date corresponding to the highest research and development stage.
The invention also provides a retrieval device, which comprises a research and development type receiving unit and a medicine screening unit, wherein:
the system comprises a research and development type receiving unit, a target research and development type receiving unit and a target development type receiving unit, wherein the research and development type receiving unit is used for receiving a target research and development type label sent by a user terminal;
the drug screening unit is used for screening drugs corresponding to the target research and development type labels from the predetermined research and development type labels of the drugs and returning information associated with the drugs to the user terminal; the development type label of each drug is determined based on the drug development type mining method as described above.
The invention also provides an electronic device, which comprises a memory, a processor and a computer program stored on the memory and capable of running on the processor, wherein the processor executes the program to realize the drug development type mining method or the drug development type retrieval method.
The present invention also provides a non-transitory computer readable storage medium having stored thereon a computer program which, when executed by a processor, implements a drug development type mining method or a drug development type retrieval method as described in any of the above.
The present invention also provides a computer program product comprising a computer program which, when executed by a processor, implements a drug development type mining method or a drug development type retrieval method as described in any of the above.
According to the medicine research and development type mining and searching method, device and electronic equipment, the medicines are clustered based on the target point and the action mechanism to obtain a plurality of medicine sets; and determining the research and development type labels of the medicines in the medicine sets based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the research and development milestone date corresponding to the highest research and development stage. The research and development types of the medicines can be accurately and clearly defined and marked in a label form, so that comprehensive and reliable medicine research and development type mining is realized, and the obtained research and development types of the medicines provide convenience for searching the medicines with advanced innovation.
Drawings
In order to more clearly illustrate the technical solutions of the present invention or the prior art, the drawings needed for the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and those skilled in the art can also obtain other drawings according to the drawings without creative efforts.
FIG. 1 is a schematic flow chart of a drug development type mining method provided by the present invention;
FIG. 2 is a schematic representation of a target point hierarchy map provided by the present invention;
FIG. 3 is a schematic flow chart of a retrieval method provided by the present invention;
FIG. 4 is a schematic structural view of a drug development type excavating apparatus provided in the present invention;
FIG. 5 is a schematic structural diagram of a search device provided in the present invention;
fig. 6 is a schematic structural diagram of an electronic device provided in the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The pharmaceutical industry generally has some informal definitions of innovative drugs, such as FIC (first in class), fast follow, me to, BIC (best in class), me beter, and the like. However, these definitions do not have a standard, and the knowledge of these definitions in the industry is not consistent, nor is there a corresponding medical database product.
For medical analysts or investors, it is highly desirable to have an efficient method for rapidly finding out the drugs of the first three of FIC, BIC, and Follow from the innovative drugs and investing in their research and development enterprises.
Based on the above, the embodiment of the invention provides a drug development type mining method, which can accurately and clearly define the development types of the drugs, so as to help a user to quickly locate the truly innovative drugs.
Fig. 1 is a schematic flow chart of a drug development type mining method provided by the present invention, and as shown in fig. 1, the method includes:
and step 110, acquiring target points, action mechanisms, research and development stages and research and development milestone dates corresponding to the medicines.
Specifically, the target corresponding to each drug refers to a binding site of each drug and a biological macromolecule in a body, such as a PDI (Protein kinase) target. The target points corresponding to the medicines can be obtained through the pre-established association relation knowledge graph of the target points and the medicines.
And acquiring the action mechanism corresponding to each medicine through the instruction book of each medicine. Aiming at the same target point, innovative medicines with different action mechanisms emerge in the history of medicine research and development. For example: aiming at the target CD22, drugs with different action mechanisms such as CAR-T cell therapy, antibody coupling drugs, monoclonal antibodies, radioimmunotherapy, NK cell therapy and the like are continuously developed.
The development stages corresponding to each drug, i.e. the development process of the drug, generally include, for the purpose of creating a drug: preclinical-application clinical-approval clinical-phase I clinical trial-phase I/II clinical trial-phase II/III clinical trial-phase III clinical trial-application marketing-approval marketing.
The development milestone date corresponding to each medicine is the start date corresponding to each node in the medicine development process.
The target, action mechanism and research and development stage corresponding to each medicine can be obtained through medicine marketing information, medicine registration information, clinical trial information, enterprise bulletins, thesis documents and the like, and the research and development milestone date is determined according to the starting time of each research and development stage.
Further, on the basis of obtaining the target point, action mechanism, research and development stage and research and development milestone date data corresponding to each medicine, standardized data can be cleaned, and specifically, the obtained data can be matched in a corresponding dictionary to obtain corresponding standardized data.
And 120, clustering the medicines based on the target points and the action mechanism to obtain a plurality of medicine sets.
In particular, considering that the targets and action mechanisms corresponding to the same type of innovative drugs are generally the same, mining for the research and development types of each drug can be performed in the same type of innovative drugs.
And clustering the medicines with the same target and action mechanism to obtain a plurality of medicine sets. It is understood that for any drug set, the target and mechanism of action of each drug contained therein is the same.
It should be noted that, since the target point corresponding to each drug may be a single target point or a plurality of target points. Aiming at the single-target medicine, the targets are completely the same, namely the targets are the same; aiming at multi-target drugs, all the corresponding targets of all the drugs are the same or belong to the relationship of complete inclusion and inclusion, namely, the targets are the same.
Specifically, for any drug set, the highest research and development stage of the corresponding research and development stages of each drug may reflect the degree of innovation of each drug in the drug set to some extent. Such as those that have been approved for marketing at the highest stage of development, the degree of innovation of those that have been approved for marketing is relatively high compared to those that do not include them.
Meanwhile, the development milestone date corresponding to the highest development stage can also reflect the innovation degree of each medicine in the medicine set. For example, when the highest research and development stages are approved for marketing, the degree of innovation of each drug with a relatively early research and development milestone date corresponding to the highest research and development stages is relatively high.
Therefore, the development type label of each medicine in each medicine set can be determined according to the highest development stage in the development stages corresponding to each medicine in each medicine set and the development milestone date corresponding to the highest development stage.
Here, the development type label of each drug may mark the innovation degree of each drug, and the development type label of each drug may specifically include FIC (first in class), BIC (last in class), fast follow, and me too. And can be subdivided under any type of label based on the research and development sequence of the medicines, such as FIC subdivided into 1st IC, 2nd IC and 3rd IC (8230), fast follow subdivided into 1st follow, 2nd follow and 3rd follow (8230), and the like.
According to the drug research and development type mining method provided by the embodiment of the invention, each drug is clustered based on a target point and an action mechanism to obtain a plurality of drug sets; and determining the research and development type labels of the medicines in the medicine sets based on the highest research and development stage of the corresponding research and development stages of the medicines in the medicine sets and the research and development milestone date corresponding to the highest research and development stage. The research and development types of the medicines can be accurately and clearly defined and marked in a label form, so that comprehensive and reliable medicine research and development type mining is realized, and the obtained research and development types of the medicines provide convenience for searching the medicines with advanced innovation.
Based on the above embodiment, step 130 specifically includes:
step 131, based on the highest research and development stage in the research and development stages corresponding to each drug in each drug set and the order from front to back of the research and development milestone date corresponding to the highest research and development stage, ranking each drug in each drug set, and determining the research and development type label of each drug in each drug set.
Specifically, on the basis of obtaining the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the research and development milestone date corresponding to the highest research and development stage, the medicines in the medicine sets can be further sorted.
For example, the medicines may be sequenced according to the research and development sequence of the highest research and development stage, or the medicines may be sequenced according to the research and development milestone date corresponding to the highest research and development stage from the front to the back, or the medicines may be sequenced according to the research and development sequence of the highest research and development stage and the research and development milestone date corresponding to the highest research and development stage at the same time, which is not specifically limited in the embodiment of the present invention.
On the basis of obtaining the sorting result of each medicine, the research and development type label of each medicine in each medicine set can be determined according to the sorting result.
In one embodiment, if the highest development stage of the development stages corresponding to each drug in each drug set does not include approval to go to the market, the development type labels of the drugs in each drug set are determined to be, in order, based on the sorting result: 1st IC, 2nd IC, 3rd IC \8230.
According to the method provided by the embodiment of the invention, the medicines in the medicine sets are sequenced based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the research and development milestone date corresponding to the highest research and development stage, the research and development type labels of the medicines in the medicine sets are determined, and accurate and reliable research and development type definition and marking are realized.
Based on any of the above embodiments, step 131 specifically includes:
determining that the research and development type label of the earliest approved medicine on the market in each medicine set is 1st IC based on the date corresponding to the approval on the market when the highest research and development stage in the research and development stages corresponding to each medicine in each medicine set is approved to be on the market;
sequencing the other medicines based on the sequence of development milestone dates corresponding to the highest development stages of the other medicines from front to back, and determining development type labels of the folow types of the other medicines, wherein the other medicines are medicines in the medicine sets except the medicine which is approved to be listed earliest;
and under the condition that the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets does not comprise approval for marketing, sequencing the medicines in the medicine sets based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the sequence of the development milestone date corresponding to the highest research and development stage from front to back, and determining the research and development type labels of the IC types of the medicines in the medicine sets.
Specifically, for any drug set, when the highest development stage in the development stages corresponding to each drug in each drug set is approved for marketing, the approved drugs in each drug set for marketing may be further sorted according to the date corresponding to approved marketing, the earliest approved drug in each drug set for marketing is determined, and the development type label of the earliest approved drug in each drug set is labeled as 1st IC.
Meanwhile, except the earliest approved medicine on the market, the medicines in each medicine set, namely the rest medicines, are sorted according to the development milestone date corresponding to the highest development stage of the rest medicines, and the development type labels of the rest medicines are determined and can be respectively marked as: 1st folow, 2nd folow, 3rd folow \8230.
If the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets does not include approval to go to the market, determining that the research and development type labels of the medicines in the medicine sets are sequentially as follows based on the sorting result: 1st IC, 2nd IC, 3rd IC \8230.
The method provided by the embodiment of the invention is used for marking the research and development type of the earliest approved medicine on the market and the research and development type labels of other medicines respectively according to whether the highest research and development stage in the corresponding research and development stages of the medicines comprises approval for marketing or not, so that more accurate and clear research and development type definition and marking are realized.
Based on any of the above embodiments, step 131 further includes:
in case the indication of any drug is related to a breakthrough therapy, the development type label BIC is added to the development type label of said any drug.
Specifically, the indication of any drug can be obtained based on the association relationship between the drug and the indication. The method comprises the steps of determining whether indications of the medicine are related to breakthrough therapy or not by monitoring announcements sent by medicine supervision departments of various countries, and acquiring the indications of the breakthrough therapy disclosed in the announcements sent by the medicine supervision departments.
In the case where the indication for any drug is related to breakthrough therapy, the development type label BIC is added to the development type label for that drug. Namely, the development type label of the drug includes not only 2nd in class or 3rd in class \8230butalso BIC.
Furthermore, in the case of multiple indications of the same drug, not all indications are BIC, and the indications of the breakthrough therapy disclosed by the drug administration can be labeled on the drug.
In the method provided by the embodiment of the invention, under the condition that the indication of any medicine is related to breakthrough therapy, the development type label of the medicine also comprises BIC.
Based on any of the above embodiments, step 130 further includes:
and under the conditions that the action mechanisms of the medicine sets are the same, the number of the target points is the same, and the relationship between any target point in each medicine set and any target point in other medicine sets meets a preset target point level map, carrying out research and development type label adjustment based on the highest research and development stage and the target point corresponding to the medicine with the research and development type label of 1st IC in each medicine set.
Specifically, in consideration of the fact that there are upper and lower hierarchical relationships between targets, for example, there are two types of IGF (insulin like growth factor), IGF-I and IGF-II, based on the above drug development type mining method, the corresponding drugs will be clustered in different drug collections based on the difference between IGF-I and IGF targets, and if IGF-I is researched by an existing research and development organization a and then IGF is researched by another research and development organization B, the research and development organization B does not develop drugs based on IGF-based drug information as a real innovative drug, so the development type label of the drugs needs to be adjusted.
In this embodiment, a target point level map may be constructed in advance. Fig. 2 is a schematic diagram of a target point hierarchy provided by the present invention, as shown in fig. 2, the target point hierarchy may be a tree structure, each upper level target point may comprise one or more lower level target points, and the target point "ABC" in fig. 2 comprises four lower level target points "ABCA", "ABCG", "ABCD", and "ABCB", respectively, wherein the target point "ABCA" comprises three lower level target points, "ABCA7", "ABCA4", and "ABCA1", respectively.
Under the condition that the action mechanisms of the medicine sets are the same, the number of the target points is the same, and the relationship between any target point in each medicine set and any target point in other medicine sets meets a preset target point level map, namely the upper and lower level relationships exist between any target point in each medicine set, the highest research and development stages corresponding to the medicines with the research and development type labels of all medicines in each medicine set marked as 1st IC are compared.
On the basis, if the highest research and development stage corresponding to the lower-level target point is higher than the highest research and development stage corresponding to the upper-level target point, the research and development type labels of the medicines in the medicine set corresponding to the upper-level target point are modified into me-too.
According to the method provided by the embodiment of the invention, aiming at each medicine set with hierarchical relation among target points, the development type label is adjusted based on the highest development stage and the target point corresponding to the medicine with the development type label of 1st IC, so that the reliable and accurate development of the medicine development type is further realized, and the accuracy of the excavator of the medicine development type is improved.
Based on any of the above embodiments, the development milestone date corresponding to each drug in step 110 is determined based on the following steps, including:
determining a development milestone date corresponding to each medicine based on the medicine name, the development mechanism and the development progress corresponding start time of each medicine;
the development progress corresponding start time includes at least one of an approval time to market, an application time to market, a start time of each clinical development phase, an approval clinical time, and an application clinical time.
Specifically, the development milestone date corresponding to each drug can be determined by the following method:
firstly, clustering the medicines based on the medicine names and the research and development mechanisms of the medicines, and determining the research and development milestone date corresponding to each medicine based on the corresponding start time of the research and development progress of each medicine under the clustering set.
The corresponding start time of the development progress includes at least one of approval time to market, application time to market, start time of each clinical development stage, approval clinical time, and application clinical time, and a method for determining the corresponding start time of each development progress is described below.
(1) Time to market approved: the time of the market disclosed by official websites of each country takes the earliest time of the market as the approved time of the market;
(2) Application for time to market: the earliest time of applying for marketing obtained by the following method is taken as the time of applying for marketing;
the time of the drug application on the market in China: the application time of each Drug can be obtained from the CDE (central For Drug Evaluation) in the state Drug administration, considering that the CDE is managed according to the acceptance number, there may be several or even thousands of acceptance number data For the same Drug in the same enterprise, and the information obtained in the CDE includes but is not limited to: the general name of the medicine, the dosage form, the research and development organization, the acceptance number, the acceptance date, the application item, the examination and evaluation conclusion and the examination and conclusion date;
data can be aggregated in advance based on the same common name of the drug, the dosage form of the drug and the information of research and development institutions, and the aggregated information of each drug can be displayed as shown in the following table 1:
TABLE 1
The time of application to market is: application = S (S means application production), and the earliest date among the corresponding acceptance date and acceptance date is acquired; if any date has no value, taking value data;
drug products were marketed at foreign applications: the method can be obtained based on announcements issued by research and development institutions;
(3) Start time of each clinical development phase: including the start time of phase I clinical trial, phase I/II clinical trial, phase II/III clinical trial, and phase III clinical trial;
acquiring corresponding research and development stages and group entry time of a first example of subject based on each national clinical registration platform, and taking the group entry time of the corresponding first example of subject with the earliest target research and development stage as the start time of the target clinical research and development stage;
(4) Approved clinical time: the earliest approved clinical time obtained as follows was taken as the approved clinical time;
the clinical approval time of the medicine in China is as follows: the time of the approval to the clinic, as in the time of market of the above application, was: application = L (L means application clinical) and review conclusion = approval clinical, or application = R (application review) and review conclusion = approval clinical, the earliest date of the approval dates being obtained as the time of approval clinical in the country of the drug;
drug approval clinical time abroad: the method can be obtained based on announcements issued by research and development institutions;
it should be noted that, all countries are generally clinical implied permission systems, and actually recorded approval dates are clinical implied permission schedules;
(5) Application of clinical time: the earliest applied clinical time obtained as follows is used as the applied clinical time;
the medicine is applied for clinical time at home: the time of the application for clinical application is as follows: application item = L (L indicates application clinical), and the earliest date of the acceptance date and the acceptance date is acquired as the time of application clinical of the drug in China;
drug approval clinical time abroad: the acquisition may be based on announcements issued by the research and development institution.
According to the method provided by the embodiment of the invention, the development milestone date corresponding to each medicine is determined based on at least one of approval time to market, application time to market, start time of each clinical development stage, approval clinical time and application time.
Based on any of the above embodiments, fig. 3 is a schematic flow chart of the retrieval method provided by the present invention, and as shown in fig. 3, the retrieval method includes:
Specifically, each medicine can be mined according to the research and development type through the embodiment, so that the research and development type label corresponding to each medicine is obtained. The obtained research and development type labels of the medicines provide convenience for innovative and leading medicine searching. On the basis, a retrieval system can be constructed to facilitate quick searching and matching of target medicines.
The user can input the target research and development type label through a user terminal in the form of a smart phone, a computer, a tablet computer and the like, and the target research and development type label is sent to a server for retrieval. The target development type label is a development type label of a medicine for which related information is desired to be found.
After receiving the target development type labels, the medicines corresponding to the target development type labels can be located in the development type labels of the medicines, and the information associated with the medicines is returned to the user terminal for the user terminal to view.
The retrieval method provided by the embodiment of the invention realizes the quick retrieval of the innovative medicines corresponding to the target research and development type label, is beneficial to improving the search efficiency of innovative and leading medicines, and can help a user to quickly and accurately inquire the innovative and leading medicines.
Based on any one of the embodiments, a drug retrieval method is provided, including:
s1, obtaining corresponding target points, action mechanisms, research and development stages and research and development milestone dates of each medicine.
(1) Acquiring information of marketed drugs: the method can acquire a drug marketing information table of all the years based on drug management official websites NMPA/FDA/EMA/HMA/PMDA and the like of all the countries, wherein the acquired information comprises but is not limited to drug names, research and development institutions, indication information and marketing time information;
(2) Acquiring information of a medicine under development: information that may be obtained based on national clinical trial registration platforms, CDE/ChiCTR, enterprise-acquired papers published by the enterprise, issued publications, applied patents, listed company documents, etc., includes, but is not limited to: the method comprises the following steps of (1) medicine name, research and development mechanisms, indication information, research and development progress corresponding start time, medicine corresponding targets and action mechanisms;
(3) A medicine name dictionary, an enterprise dictionary, an indication dictionary, a target dictionary and an action mechanism dictionary are constructed in advance, and matching is carried out in corresponding dictionaries based on the acquired data to obtain corresponding standard information;
(4) And clustering the data based on the drug name and the research and development mechanism to obtain the research and development mileage date of the target drug.
And S2, clustering the medicines based on the target points and the action mechanism to obtain a plurality of medicine sets.
And S3, determining the research and development type labels of the medicines in the medicine sets based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the research and development milestone date corresponding to the highest research and development stage.
And S4, receiving the target research and development type label sent by the user terminal.
And S5, screening the medicine corresponding to the target research and development type label from the predetermined research and development type labels of the medicines, and returning the information associated with the medicine to the user terminal.
The following describes the drug development type excavating device provided by the present invention, and the drug development type excavating device described below and the drug development type excavating method described above may be referred to in correspondence with each other.
Based on any of the above embodiments, fig. 4 is a schematic structural diagram of the drug development type mining device provided by the present invention, as shown in fig. 4, the device includes an information obtaining unit 410, a drug clustering unit 420, and a development type determining unit 430, wherein,
the information acquisition unit 410 is used for acquiring target points, action mechanisms, research and development stages and research and development milestone dates corresponding to the medicines;
a drug clustering unit 420, configured to cluster the drugs based on the target point and the action mechanism to obtain a plurality of drug sets;
the research and development type determining unit 430 is configured to determine a research and development type label of each medicine in each medicine set based on a highest research and development stage in the research and development stages corresponding to each medicine in each medicine set and a research and development milestone date corresponding to the highest research and development stage.
The drug research and development type excavating device provided by the embodiment of the invention clusters each drug based on the target point and the action mechanism to obtain a plurality of drug sets; and determining the research and development type labels of the medicines in the medicine sets based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the research and development milestone date corresponding to the highest research and development stage. The research and development types of the medicines can be accurately and clearly defined and marked in a label form, so that comprehensive and reliable medicine research and development type mining is realized, and the obtained research and development types of the medicines provide convenience for searching the medicines with advanced innovation.
Based on any of the above embodiments, the development type determining unit 430 is further configured to:
based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the sequence of the research and development milestone date corresponding to the highest research and development stage from front to back, the medicines in the medicine sets are sequenced, and the research and development type labels of the medicines in the medicine sets are determined.
Based on any of the above embodiments, the development type determining unit 430 is further configured to:
determining that the research and development type label of the earliest approved medicine on the market in each medicine set is 1st IC based on the date corresponding to the approval on the market when the highest research and development stage in the research and development stages corresponding to each medicine in each medicine set is approved to be on the market;
sequencing the other medicines based on the sequence of development milestone dates corresponding to the highest development stages of the other medicines from front to back, and determining development type labels of the folow types of the other medicines, wherein the other medicines are medicines in the medicine sets except the medicine which is approved to be listed earliest;
and under the condition that the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets does not comprise approval for marketing, sequencing the medicines in the medicine sets based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the sequence of the development milestone date corresponding to the highest research and development stage from front to back, and determining the research and development type labels of the IC types of the medicines in the medicine sets.
Based on any of the above embodiments, the apparatus further includes a development type increasing unit, configured to:
in case the indication for any drug is related to breakthrough therapy, the development type label BIC is added to the development type label for said any drug.
Based on any of the above embodiments, the apparatus further includes a development type adjustment unit, configured to:
under the conditions that the action mechanisms of the medicine sets are the same, the number of targets is the same, and the relationship between any target in each medicine set and any target in other medicine sets meets a preset target level map, the research and development type label is adjusted based on the highest research and development stage and target corresponding to the medicine with the research and development type label of 1st IC in each medicine set.
Based on any of the above embodiments, the development type excavation apparatus further includes a development milestone date determination unit configured to:
determining a development milestone date corresponding to each medicine based on the medicine name, the development mechanism and the development progress corresponding start time of each medicine;
the development progress corresponding start time includes at least one of an approval time to market, an application time to market, a start time of each clinical development stage, an approval clinical time, and an application clinical time.
The following describes a retrieval apparatus provided by the present invention, and the retrieval apparatus described below and the retrieval method described above may be referred to correspondingly.
Based on any of the above embodiments, fig. 5 is a schematic structural diagram of a retrieval apparatus provided by the present invention, as shown in fig. 5, the apparatus includes a development type receiving unit 510 and a drug screening unit 520, where:
a development type receiving unit 510, configured to receive a target development type tag sent by a user terminal;
a drug screening unit 520, configured to screen a drug corresponding to the target development type label from predetermined development type labels of each drug, and return information associated with the drug to the user terminal; the development type label of each medicine is determined based on the medicine development type mining method.
The retrieval device provided by the embodiment of the invention realizes the rapid retrieval of the innovative medicines corresponding to the target research and development type label, is beneficial to improving the search efficiency of innovative and leading medicines, and can help a user to quickly and accurately search the innovative and leading medicines.
Fig. 6 illustrates a physical structure diagram of an electronic device, which may include, as shown in fig. 6: a processor (processor) 610, a communication Interface (Communications Interface) 620, a memory (memory) 630 and a communication bus 640, wherein the processor 610, the communication Interface 620 and the memory 630 communicate with each other via the communication bus 640. The processor 610 may invoke logic instructions in the memory 630 to perform a drug development type mining method comprising: acquiring target points, action mechanisms, research and development stages and research and development milestone dates corresponding to the medicines; clustering the medicines based on the target points and the action mechanism to obtain a plurality of medicine sets; determining a research and development type label of each medicine in each medicine set based on the highest research and development stage in the research and development stage corresponding to each medicine in each medicine set and the research and development milestone date corresponding to the highest research and development stage.
The processor 610 may invoke logic instructions in the memory 630 to perform a retrieval method comprising: receiving a target research and development type label sent by a user terminal; screening out the medicines corresponding to the target research and development type labels from the predetermined research and development type labels of the medicines, and returning information associated with the medicines to the user terminal; the development type label of each drug is determined based on the drug development type mining method.
In addition, the logic instructions in the memory 630 may be implemented in software functional units and stored in a computer readable storage medium when the logic instructions are sold or used as independent products. Based on such understanding, the technical solution of the present invention may be embodied in the form of a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device) to execute all or part of the steps of the method according to the embodiments of the present invention. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes.
In another aspect, the present invention also provides a computer program product, the computer program product including a computer program, the computer program being stored on a non-transitory computer-readable storage medium, wherein when the computer program is executed by a processor, a computer is capable of executing the drug development type mining method provided by the above methods, the method including: acquiring target points, action mechanisms, research and development stages and research and development milestone dates corresponding to the medicines; clustering the medicines based on the target points and the action mechanism to obtain a plurality of medicine sets; determining a research and development type label of each medicine in each medicine set based on the highest research and development stage in the research and development stage corresponding to each medicine in each medicine set and the research and development milestone date corresponding to the highest research and development stage.
When the computer program is executed by a processor, the computer can execute the searching method provided by the methods, and the method comprises the following steps: receiving a target research and development type label sent by a user terminal; screening out the medicines corresponding to the target research and development type labels from the predetermined research and development type labels of the medicines, and returning information associated with the medicines to the user terminal; the development type label of each medicine is determined based on the medicine development type mining method.
In yet another aspect, the present invention also provides a non-transitory computer-readable storage medium, on which a computer program is stored, the computer program, when executed by a processor, implementing a drug development type mining method provided by performing the above methods, the method including: acquiring target points, action mechanisms, research and development stages and research and development milestone dates corresponding to the medicines; clustering the medicines based on the target points and the action mechanism to obtain a plurality of medicine sets; determining a research and development type label of each medicine in each medicine set based on the highest research and development stage in the research and development stage corresponding to each medicine in each medicine set and the research and development milestone date corresponding to the highest research and development stage.
The computer program is implemented to perform a retrieval method provided by the methods when executed by a processor, the method comprising: receiving a target research and development type label sent by a user terminal; screening out the medicines corresponding to the target research and development type labels from the predetermined research and development type labels of the medicines, and returning information associated with the medicines to the user terminal; the development type label of each drug is determined based on the drug development type mining method.
The above-described embodiments of the apparatus are merely illustrative, and the units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of the present embodiment. One of ordinary skill in the art can understand and implement it without inventive effort.
Through the above description of the embodiments, those skilled in the art will clearly understand that each embodiment can be implemented by software plus a necessary general hardware platform, and certainly can also be implemented by hardware. With this understanding in mind, the above-described technical solutions may be embodied in the form of a software product, which can be stored in a computer-readable storage medium such as ROM/RAM, magnetic disk, optical disk, etc., and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute the methods described in the embodiments or some parts of the embodiments.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (9)
1. A drug development type mining method is characterized by comprising the following steps:
acquiring target points, action mechanisms, research and development stages and research and development milestone dates corresponding to the medicines;
clustering the medicines based on the target points and the action mechanism to obtain a plurality of medicine sets;
determining a research and development type label of each medicine in each medicine set based on the highest research and development stage in the research and development stage corresponding to each medicine in each medicine set and the research and development milestone date corresponding to the highest research and development stage;
determining a development type label of each drug in each drug set based on a highest development stage in development stages corresponding to each drug in each drug set and a development milestone date corresponding to the highest development stage, and then further comprising:
and under the condition that the action mechanisms corresponding to the medicine sets are the same, the number of the target points is the same, and the relationship between any target point in each medicine set and any target point in other medicine sets meets a preset target point level map, adjusting the research and development type label based on the highest research and development stage and the target point corresponding to the medicine with the research and development type label of 1st IC in each medicine set.
2. The method of claim 1, wherein determining the development type label of each drug in each drug set based on the highest development stage in the development stages corresponding to each drug in each drug set and the development milestone date corresponding to the highest development stage comprises:
based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the sequence of the research and development milestone date corresponding to the highest research and development stage from front to back, the medicines in the medicine sets are sequenced, and the research and development type labels of the medicines in the medicine sets are determined.
3. The method according to claim 2, wherein the determining the development type label of each drug in each drug set by sorting the drugs in each drug set based on the highest development stage in the development stages corresponding to each drug in each drug set and the order of the development milestone date corresponding to the highest development stage from front to back comprises:
under the condition that the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets is approved to be listed, determining the research and development type label of the medicine which is approved to be listed earliest in the medicine sets to be 1st IC based on the date corresponding to the approved to be listed;
sequencing the other medicines based on the sequence of development milestone dates corresponding to the highest development stages of the other medicines from front to back, and determining development type labels of the folow types of the other medicines, wherein the other medicines are medicines in the medicine sets except the medicine which is approved to be listed earliest;
and under the condition that the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets does not comprise approval for marketing, sequencing the medicines in the medicine sets based on the highest research and development stage in the research and development stages corresponding to the medicines in the medicine sets and the sequence of the development milestone date corresponding to the highest research and development stage from front to back, and determining the research and development type labels of the IC types of the medicines in the medicine sets.
4. The method of claim 2, wherein the step of ranking the drugs in each drug collection and determining the development type labels of the drugs in each drug collection based on the highest development stage in the development stages corresponding to the drugs in each drug collection and the order of the development milestone dates corresponding to the highest development stages from front to back comprises the steps of:
in case the indication of any drug is related to a breakthrough therapy, the development type label BIC is added to the development type label of said any drug.
5. The drug development type mining method according to any one of claims 1 to 4, wherein the development milestone date corresponding to each drug is determined based on the following steps:
determining a research and development milestone date corresponding to each medicine based on the medicine name, the research and development mechanism and the corresponding start time of the research and development progress of each medicine;
the development progress corresponding start time includes at least one of an approval time to market, an application time to market, a start time of each clinical development stage, an approval clinical time, and an application clinical time.
6. A retrieval method, comprising:
receiving a target research and development type label sent by a user terminal;
screening out the medicines corresponding to the target research and development type labels from the predetermined research and development type labels of the medicines, and returning information associated with the medicines to the user terminal; the development type label of each medicine is determined based on the medicine development type mining method according to any one of claims 1 to 5.
7. A drug development type excavating device comprising:
the information acquisition unit is used for acquiring target points, action mechanisms, research and development stages and research and development milestone dates corresponding to the medicines;
the medicine clustering unit is used for clustering the medicines based on the target points and the action mechanism to obtain a plurality of medicine sets;
the system comprises a research and development type determining unit, a data processing unit and a data processing unit, wherein the research and development type determining unit is used for determining a research and development type label of each medicine in each medicine set based on the highest research and development stage in the research and development stage corresponding to each medicine in each medicine set and the research and development milestone date corresponding to the highest research and development stage;
further comprising:
and the label adjusting unit is used for adjusting the research and development type labels based on the highest research and development stage and the target point corresponding to the medicine with the research and development type label of 1st IC in each medicine set under the conditions that the action mechanisms corresponding to the medicine sets are the same, the number of the target points is the same, and the relationship between any target point in each medicine set and any target point in other medicine sets meets a preset target point level map.
8. A retrieval apparatus, comprising:
the system comprises a research and development type receiving unit, a target research and development type receiving unit and a target development type receiving unit, wherein the research and development type receiving unit is used for receiving a target research and development type label sent by a user terminal;
the drug screening unit is used for screening drugs corresponding to the target research and development type labels from the predetermined research and development type labels of the drugs and returning information associated with the drugs to the user terminal; the development type label of each medicine is determined based on the medicine development type mining method according to any one of claims 1 to 5.
9. An electronic device comprising a memory, a processor and a computer program stored on the memory and executable on the processor, wherein the processor implements the drug development type mining method according to any one of claims 1 to 5 or the retrieval method according to claim 6 when executing the program.
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