CN114837019A - White cardboard for medicine bag and preparation method thereof - Google Patents
White cardboard for medicine bag and preparation method thereof Download PDFInfo
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- CN114837019A CN114837019A CN202210431885.5A CN202210431885A CN114837019A CN 114837019 A CN114837019 A CN 114837019A CN 202210431885 A CN202210431885 A CN 202210431885A CN 114837019 A CN114837019 A CN 114837019A
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- carboxymethyl chitosan
- white cardboard
- coating liquid
- coating
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- 239000003814 drug Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title abstract description 11
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 74
- 239000011248 coating agent Substances 0.000 claims abstract description 56
- 238000000576 coating method Methods 0.000 claims abstract description 56
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 48
- 229920001661 Chitosan Polymers 0.000 claims abstract description 46
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 44
- 239000011787 zinc oxide Substances 0.000 claims abstract description 37
- 239000007788 liquid Substances 0.000 claims abstract description 36
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 20
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 20
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 20
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 20
- 239000000123 paper Substances 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 239000011247 coating layer Substances 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 35
- 239000004626 polylactic acid Substances 0.000 claims description 35
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 4
- 244000063299 Bacillus subtilis Species 0.000 abstract description 5
- 235000014469 Bacillus subtilis Nutrition 0.000 abstract description 5
- 241000588724 Escherichia coli Species 0.000 abstract description 5
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 5
- 239000005022 packaging material Substances 0.000 abstract description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 57
- 230000001681 protective effect Effects 0.000 description 26
- 230000000052 comparative effect Effects 0.000 description 16
- 230000000694 effects Effects 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 230000004888 barrier function Effects 0.000 description 7
- 239000010410 layer Substances 0.000 description 7
- 230000003115 biocidal effect Effects 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical group ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 5
- 239000002131 composite material Substances 0.000 description 5
- 239000000835 fiber Substances 0.000 description 5
- 238000004806 packaging method and process Methods 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 229960001701 chloroform Drugs 0.000 description 4
- 238000011056 performance test Methods 0.000 description 4
- 230000007774 longterm Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000019504 cigarettes Nutrition 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 235000021056 liquid food Nutrition 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920001131 Pulp (paper) Polymers 0.000 description 1
- 239000002174 Styrene-butadiene Substances 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 238000003490 calendering Methods 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- -1 silver ions Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H27/00—Special paper not otherwise provided for, e.g. made by multi-step processes
- D21H27/10—Packing paper
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H19/00—Coated paper; Coating material
- D21H19/36—Coatings with pigments
- D21H19/38—Coatings with pigments characterised by the pigments
- D21H19/385—Oxides, hydroxides or carbonates
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H19/00—Coated paper; Coating material
- D21H19/36—Coatings with pigments
- D21H19/44—Coatings with pigments characterised by the other ingredients, e.g. the binder or dispersing agent
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H19/00—Coated paper; Coating material
- D21H19/36—Coatings with pigments
- D21H19/44—Coatings with pigments characterised by the other ingredients, e.g. the binder or dispersing agent
- D21H19/52—Cellulose; Derivatives thereof
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H19/00—Coated paper; Coating material
- D21H19/80—Paper comprising more than one coating
- D21H19/82—Paper comprising more than one coating superposed
- D21H19/822—Paper comprising more than one coating superposed two superposed coatings, both being pigmented
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H21/00—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties
- D21H21/50—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties characterised by form
- D21H21/52—Additives of definite length or shape
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
- Y02W90/10—Bio-packaging, e.g. packing containers made from renewable resources or bio-plastics
Abstract
The application relates to the technical field of packaging materials, and particularly discloses a white cardboard for a medicine bag and a preparation method thereof. The ivory board for the medicine bag comprises base paper and a coating layer, wherein the coating layer comprises the following raw materials in parts by weight: 40-60 parts of carboxymethyl chitosan, 2-4 parts of microcrystalline cellulose, 30-45 parts of nano calcium carbonate and 1.2-1.5 parts of nano zinc oxide; the preparation method comprises the following steps: s1, dispersing carboxymethyl chitosan in water, preparing a carboxymethyl chitosan solution with the mass percentage concentration of 2-3%, adding other raw materials into the carboxymethyl chitosan solution, and uniformly mixing to obtain a coating liquid; s2, coating the coating liquid on base paper, and drying to obtain the white cardboard for the medicine bag. The bacteriostasis rate of the white cardboard on escherichia coli, bacillus subtilis and staphylococcus aureus can reach more than 90%, and the bacteriostasis rate can still reach 90% after the white cardboard is treated in an environment with 90% RH and ultraviolet irradiation for 10 days.
Description
Technical Field
The application relates to the technical field of packaging materials, in particular to a white cardboard for medicine bags and a preparation method thereof.
Background
The white cardboard is a kind of white cardboard made of thick, solid and high-quality wood pulp, and is mainly used for packaging and decorating printing stock after being calendered or embossed. Classified according to the application, there are special papers, such as single-coated white cardboard for cigarette packaging, called cigarette card, non-coated base paper for liquid food packaging, called liquid food wrapping paper, various anti-counterfeit label paper, etc. Other coated white cardboard is used for packaging various goods, such as wine bottles, cosmetics, medicines, health products, etc.
Because of the particularity of the medicines, the antibacterial property of the white cardboard used for packaging the medicines has higher requirements, and the existing antibacterial materials for the white cardboard comprise organic antibacterial materials and inorganic antibacterial materials; organic antibacterial materials have certain adverse effects on human bodies and the environment, and thus the use thereof is limited; the inorganic antibacterial material is generally zinc ions or silver ions, and the inorganic antibacterial material is coated on the white cardboard through a carrier and a glue agent, so that the antibacterial effect of the white cardboard is improved.
In view of the above-mentioned related art, the applicant found that the antibacterial performance of the white cardboard coated with the inorganic antibacterial material is greatly reduced in a humid environment.
Disclosure of Invention
In order to improve the antibacterial performance of the white cardboard in a humid environment, the application provides the white cardboard for the medicine bag and the preparation method thereof.
In a first aspect, the present application provides a white cardboard for a medicine bag, which adopts the following technical scheme:
the ivory board for the medicine bag comprises base paper and a coating layer, wherein the coating layer comprises the following raw materials in parts by weight: 40-60 parts of carboxymethyl chitosan, 2-4 parts of microcrystalline cellulose, 30-45 parts of nano calcium carbonate and 1.2-1.5 parts of nano zinc oxide.
The reason why the long-term antibacterial performance of the white cardboard generally using the inorganic antibacterial agent is reduced is that moisture in the environment penetrates the white cardboard to aggravate the corrosion performance of the inorganic antibacterial material and simultaneously reduce the antibacterial performance thereof. By adopting the technical scheme, the carboxymethyl chitosan forms a protective film on the surface of the white cardboard, plays a certain role in blocking water vapor in the environment, and reduces the influence of the water vapor, thereby reducing the probability of the reduction of the antibacterial effect of the nano zinc oxide caused by the influence of the water vapor; in addition, the nano calcium carbonate and the microcrystalline cellulose are mutually adsorbed in the protective film, so that the barrier effect of the protective film is improved, the nano calcium carbonate and the microcrystalline cellulose are mutually adsorbed to form a carrier, and the nano zinc oxide is adsorbed on the carrier, so that the reduction of the antibacterial performance of the antibacterial component can be effectively prevented. Moreover, the nano calcium carbonate and the microcrystalline cellulose carrier have high specific surface area, can effectively play a role in moisture absorption and moisture prevention, and further reduce the probability of reduction of the antibacterial effect of the nano zinc oxide caused by the influence of water vapor.
Preferably, the coating layer comprises the following raw materials in parts by weight: 45-50 parts of carboxymethyl chitosan, 3-4 parts of microcrystalline cellulose, 35-40 parts of nano calcium carbonate and 1.3-1.4 parts of nano zinc oxide.
By adopting the technical scheme, the proportion of the raw materials is further optimized, and the antibacterial durability of the white cardboard is improved.
Preferably, the coating layer further includes 10 to 20 parts by weight of sodium carboxymethyl cellulose.
By adopting the technical scheme, the sodium carboxymethyl cellulose and the carboxymethyl chitosan are compounded to form the composite protective film, so that the air permeability of the composite protective film can be reduced, the barrier effect of the protective film is further improved, and the influence of the external environment on the antibacterial performance of the nano zinc oxide inorganic antibacterial material is reduced. Moreover, the formation of the composite membrane reduces the direct contact area of the fiber and water, weakens the attraction of the fiber to the water and the water surface tension, prevents the direct contact of water molecules and the fiber, increases the contact angle, reduces the permeation of water vapor, further reduces the corrosion probability of the inorganic antibacterial material, and further improves the long-term antibacterial property of the white cardboard in a humid environment.
Preferably, the particle size of the nano zinc oxide is 50-70 nm.
By adopting the technical scheme, the nano zinc oxide in the particle size range can be better dispersed and adsorbed in the carrier formed by the nano calcium carbonate and the microcrystalline cellulose, the antibacterial effect is fully exerted, if the particle size is too large, the whole specific surface area is possibly smaller, the antibacterial effect is weakened, and if the particle size is too small, the nano zinc oxide can be agglomerated in the carrier, so that the antibacterial effect is influenced.
Preferably, the coating layer further includes 70 to 100 parts by weight of polylactic acid.
Through adopting above-mentioned technical scheme, the protection film that polylactic acid formed can cover fibre and the gap between the fibre on the white cardboard, further improves the separation effect, reduces the influence of the steam in the external environment to nanometer zinc oxide antibacterial property. The ester group in the polylactic acid has good hydrophobicity, and the polylactic acid protective film can further improve the hydrophobic property of the white cardboard and reduce the water absorption of the white cardboard, thereby reducing the corrosivity of the nano zinc oxide and being beneficial to improving the long-term antibacterial effect of the white cardboard in a humid environment. In addition, polylactic acid still has antibacterial anti-enzyme's effect, and polylactic acid protection film not only can improve the barrier effect to external steam, can also cooperate with nanometer zinc oxide each other, further improves the antibacterial property of ivory board.
Preferably, the weight ratio of the nano calcium carbonate to the polylactic acid is (0.4-0.5): 1.
by adopting the technical scheme, the polylactic acid can be coated only by being dissolved in the solvent, so that the surface of the polylactic acid protective film is smooth, the proportion of the nano calcium carbonate to the polylactic acid is adjusted, the roughness of the protective film is improved to a certain extent, the waterproof effect of the polylactic acid protective film is improved, the water absorption of the white cardboard is further reduced, the corrosivity of the nano zinc oxide is reduced, and the improvement of the long-acting antibacterial property of the white cardboard in a humid environment is facilitated.
In a second aspect, the application provides a method for preparing a white cardboard for a medicine bag, which adopts the following technical scheme: a preparation method of white cardboard for medicine bags comprises the following steps:
s1, dispersing carboxymethyl chitosan in water, preparing a carboxymethyl chitosan solution with the mass percentage concentration of 2-3%, adding other raw materials into the carboxymethyl chitosan solution, and uniformly mixing to obtain a coating liquid;
and S2, coating the coating liquid obtained in the step S1 on base paper, and drying to obtain the white cardboard for medicine bags.
Preferably, the method comprises the following steps:
s1, dispersing carboxymethyl chitosan in water, preparing a carboxymethyl chitosan solution with the mass percentage concentration of 2-3%, adding other raw materials except polylactic acid and nano zinc oxide into the carboxymethyl chitosan solution, and uniformly mixing to obtain a primary coating liquid;
s2, dissolving polylactic acid in a solvent to obtain a polylactic acid solution, and then dispersing nano zinc oxide in the polylactic acid solution to obtain a secondary coating liquid;
s3, coating the primary coating liquid obtained in the step S1 on base paper and drying; then, the secondary coating liquid obtained in S2 was applied and dried to obtain a white cardboard for medicine bags.
By adopting the technical scheme, the carboxymethyl chitosan is coated on the surface of the white cardboard to form a first layer of protective film, then the polylactic acid is coated, and the nano calcium carbonate, the microcrystalline cellulose, the nano zinc oxide and the like are arranged in the polylactic acid protective film. The carboxymethyl chitosan has better film forming property, and the carboxymethyl cellulose is coated firstly, so that a uniform coating can be formed on the surface of the white cardboard, and the white cardboard is subjected to primary protection and is also a last barrier for protecting the white cardboard; polylactic acid is coated outside carboxymethyl chitosan again, form the second layer protection film outside the chitosan protection film, pinhole or the clearance that exists in the first layer protection film is filled to the second layer protection film, simultaneously, the molecule clearance in the second protection film can be filled in second layer protection film such as nano calcium carbonate, microcrystalline cellulose, nanometer zinc oxide for the outside and inside route of passing through of second protection film are blockked up, further improve the barrier effect of protection film, reduce the influence of external environment to nanometer zinc oxide, guarantee nanometer zinc oxide's antibiotic effect.
Preferably, the coating amount of the primary coating liquid is 4 to 5g/cm 3 The coating weight of the secondary coating liquid is 15-16g/cm 3 。
Through adopting above-mentioned technical scheme, adjust and prescribe a limit to the thickness of first layer protection film and second floor protection film, further improve the mating reaction between the two-layer protection film, further improve antibiotic and separation effect.
In summary, the present application has the following beneficial effects:
1. because this application adopts carboxymethyl chitosan, microcrystalline cellulose, nanometer calcium carbonate, nanometer zinc oxide is compounded and is obtained the coating layer, carboxymethyl chitosan forms the protection film on the ivory board surface, nanometer calcium carbonate and microcrystalline cellulose adsorb each other in the protection film and form the carrier, nanometer zinc oxide adsorbs on the carrier, the protection film blocks the steam in the humid environment, the antibiotic performance that the absorption carrier can effectively prevent antibiotic component reduces, and simultaneously, nanometer calcium carbonate still has certain slowly-releasing function, help improving the antibiotic persistence of nanometer zinc oxide, thereby the antibiotic persistence of ivory board in the humid environment has been improved. The bacteriostasis rate of the white cardboard on escherichia coli can reach 96.49-99.49%, the bacteriostasis rate on bacillus subtilis can reach 90.97-93.82%, and the bacteriostasis rate on staphylococcus aureus can reach 92.04-94.92%; after the white cardboard is treated in an environment of 90% RH and ultraviolet irradiation for 10 days, the bacteriostasis rate to escherichia coli can reach 95.16-98.10%, the bacteriostasis rate to bacillus subtilis can reach 90.36-93.18%, and the bacteriostasis rate to staphylococcus aureus can reach 90.94-93.79%.
2. In the application, the polylactic acid protective film and the carboxymethyl chitosan protective film are preferably compounded, and the two protective films are matched with each other, so that the antibacterial property and the antibacterial durability of the white cardboard are further improved, the antibacterial rate of the white cardboard on escherichia coli can reach 98.06-99.49%, the antibacterial rate on bacillus subtilis can reach 92.46-93.82%, and the antibacterial rate on staphylococcus aureus can reach 93.55-94.92%; after the white cardboard is treated in an environment of 90% RH and ultraviolet irradiation for 10 days, the bacteriostasis rate to escherichia coli can reach 96.70-98.10%, the bacteriostasis rate to bacillus subtilis can reach 91.83-93.18%, and the bacteriostasis rate to staphylococcus aureus can reach 92.43-93.79%.
Detailed Description
The present application will be described in further detail with reference to examples.
Raw materials
The carboxymethyl chitosan is chitosan with molecular weight of 1500;
the microcrystalline cellulose has a particle size of 30-40 μm and an ultimate degree of polymerization of 200;
the molecular weight of the sodium carboxymethyl cellulose is 265;
polylactic acid molecular weight 90;
the solvent is chloroform.
Examples
Examples 1 to 8
A white cardboard for medicine package comprises base paper and a coating layer, and the preparation method comprises the following steps:
s1, dispersing carboxymethyl chitosan in water according to the raw material proportion in Table 1, preparing a carboxymethyl chitosan solution with the mass percentage concentration of 2%, adding other raw materials into the carboxymethyl chitosan solution, and uniformly mixing to obtain a coating liquid;
s2, coating the coating liquid obtained in the step S1 on base paper, wherein the coating weight is 5g/cm 3 Standing and airing to obtain the white cardboard for the medicine bag.
TABLE 1 EXAMPLES 1-8 raw materials proportioning Table (kg)
Wherein the particle size of the nano zinc oxide is 50-70 nm.
Examples 9 to 12
A white cardboard for medicine package comprises base paper and a coating layer, and the preparation method comprises the following steps:
s1, dispersing carboxymethyl chitosan in water according to the raw material ratio in Table 2, preparing a carboxymethyl chitosan solution with the mass percentage concentration of 3%, and then adding sodium carboxymethyl cellulose to obtain a primary coating liquid;
s2, dissolving polylactic acid in a trichloromethane solvent to obtain a polylactic acid solution, and then dispersing microcrystalline cellulose, nano calcium carbonate and nano zinc oxide in the polylactic acid solution to obtain a secondary coating liquid;
s3, coating the primary coating liquid obtained in the step S1 on base paper, wherein the coating weight is 4g/cm 3 Naturally drying; then, the secondary coating liquid obtained in S2 was applied in an amount of 16g/cm 3 And naturally drying to obtain the white cardboard for the medicine bag.
TABLE 2 EXAMPLES 9-12 raw materials proportioning Table (kg)
Example 13
Unlike example 12, the amount of the primary coating liquid applied in example 13 was 5g/cm 3 The coating amount of the secondary coating liquid was 15g/cm 3 。
Example 14
Unlike example 12, the amount of the primary coating liquid applied in example 13 was 8g/cm 3 The coating amount of the secondary coating liquid was 10g/cm 3 。
Example 15
The raw materials of the embodiment 15 and the embodiment 12 have the same proportion, and the preparation method comprises the following steps:
s1, dispersing carboxymethyl chitosan in water to prepare a carboxymethyl chitosan solution with the mass percentage concentration of 3%, and then dispersing sodium carboxymethyl cellulose, microcrystalline cellulose, nano calcium carbonate and nano zinc oxide in the carboxymethyl chitosan solution to obtain a primary coating liquid;
s2, dissolving polylactic acid in a trichloromethane solvent to obtain a polylactic acid solution and obtain a secondary coating liquid;
s3, coating the primary coating liquid obtained in the step S1 on base paper, wherein the coating weight is 4g/cm 3 Naturally drying; then, the secondary coating liquid obtained in S2 was applied in an amount of 16g/cm 3 And naturally drying to obtain the white cardboard for the medicine bag.
Example 16
The raw materials of the embodiment 16 and the embodiment 12 have the same proportion, and the preparation method comprises the following steps:
s1, dispersing carboxymethyl chitosan in water to prepare a carboxymethyl chitosan solution with the mass percentage concentration of 3%, and then dispersing sodium carboxymethyl cellulose and nano zinc oxide in the carboxymethyl chitosan solution to obtain a primary coating liquid;
s2, dissolving polylactic acid in a trichloromethane solvent to obtain a polylactic acid solution, and then dispersing microcrystalline cellulose and nano calcium carbonate in the polylactic acid solution to obtain a secondary coating liquid;
s3, coating the primary coating liquid obtained in the step S1 on base paper, wherein the coating weight is 4g/cm 3 Naturally drying; then, the secondary coating liquid obtained in S2 was applied in an amount of 16g/cm 3 And naturally drying to obtain the white cardboard for the medicine bag.
Comparative example
Comparative example 1
Unlike example 1, microcrystalline cellulose was not included in comparative example 1.
Comparative example 2
Unlike example 1, nano calcium carbonate was not included in comparative example 2.
Comparative example 3
Unlike example 1, the carboxymethyl chitosan was replaced with an equal amount of styrene-butadiene latex in comparative example 3.
Performance test
Detection method/test method
According to GBT 21866-2008, the antibacterial performance tests of examples 1-16 and comparative examples 1-3 are performed, and the detection results are shown in Table 3.
The white cardboard of examples 1 to 16 and comparative examples 1 to 3 was placed in an environment of 35 ℃ and 90% RH and irradiated with 30W ultraviolet lamp of 253.7nm wavelength (ultraviolet lamp conforming to GB 19258), and after 10 days, the antibacterial test was performed again, and the test results are shown in Table 4.
TABLE 3 Performance test results
TABLE 4 Performance test results
Combining examples 1-16 and comparative examples 1-3, and combining table 3, it can be seen that the antibacterial performance of the white cardboard in examples 1-16 is better than that of comparative examples 1-3, but the white cardboard in comparative examples 1-3 is not obviously reduced compared with examples 1-16, and still meets the antibacterial requirement; combining examples 1-16 and comparative examples 1-3, and combining table 4, it can be seen that the antibacterial performance of the white cardboard in comparative examples 1-3 is significantly reduced compared with that in examples 1-16 under the double treatment of ultraviolet light and humid environment, which indicates that the white cardboard prepared by the present application has not only superior antibacterial performance, but also superior antibacterial durability, and the antibacterial performance is not significantly reduced in humid environment.
It can be seen from the combination of example 1 and comparative examples 1-3 and the combination of table 3 and table 4 that the antibacterial performance of the white cardboard in the comparative examples 1-3 is significantly reduced, which may be because carboxymethyl chitosan forms a protective film on the surface of the white cardboard, nano calcium carbonate and microcrystalline cellulose mutually adsorb in the protective film to form a carrier, nano zinc oxide is adsorbed on the carrier, the protective film blocks water vapor in a humid environment, the adsorbed carrier can effectively prevent the antibacterial performance of the antibacterial component from being reduced, and meanwhile, the nano calcium carbonate has a certain slow release function, which is helpful to improve the antibacterial durability of the nano zinc oxide, thereby improving the antibacterial durability of the white cardboard in the humid environment.
It can be seen from the combination of examples 3 and 6 to 8 and the combination of table 3 and table 4 that the antibacterial performance and the antibacterial durability of the ivory board in examples 6 to 8 are both improved, which may be because the carboxymethylcellulose sodium and the carboxymethyl chitosan are compounded to form the composite protective film, which can reduce the air permeability of the composite protective film, further improve the barrier effect of the protective film, reduce the influence of water vapor in a humid environment, ensure the antibacterial effect of the nano zinc oxide, and improve the antibacterial durability of the nano zinc oxide.
Combining example 7 with examples 9-12, and combining table 3 with table 4, it can be seen that the antibacterial performance and antibacterial durability of the ivory board in examples 9-12 are both improved, which may be because the carboxymethyl chitosan protective film and the polylactic acid protective film are formed on the surface of the ivory board in sequence, and the polylactic acid protective film fills up the pinholes or gaps existing in the carboxymethyl chitosan protective film; further improving the barrier effect of the protective film, reducing the influence of water vapor in a humid environment, ensuring the antibacterial effect of the nano zinc oxide and improving the antibacterial durability of the nano zinc oxide.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (9)
1. The ivory board for the medicine bag comprises base paper and a coating layer, and is characterized in that the coating layer comprises the following raw materials in parts by weight: 40-60 parts of carboxymethyl chitosan, 2-4 parts of microcrystalline cellulose, 30-45 parts of nano calcium carbonate and 1.2-1.5 parts of nano zinc oxide.
2. A white cardboard for a pack of medicine according to claim 1, wherein: the coating layer comprises the following raw materials in parts by weight: 45-50 parts of carboxymethyl chitosan, 3-4 parts of microcrystalline cellulose, 35-40 parts of nano calcium carbonate and 1.3-1.4 parts of nano zinc oxide.
3. The ivory board for medicine package according to claim 1, wherein: the coating layer further comprises 10-20 parts by weight of sodium carboxymethyl cellulose.
4. The ivory board for medicine package according to claim 1, wherein: the particle size of the nano zinc oxide is 50-70 nm.
5. The ivory board for medicine package according to claim 1, wherein: the coating layer further comprises 70-100 parts by weight of polylactic acid.
6. The ivory board for medicine package according to claim 5, wherein: the weight ratio of the nano calcium carbonate to the polylactic acid is (0.4-0.5): 1.
7. a method for preparing a ivory board for pharmaceutical packs according to any of claims 1 to 4, comprising the steps of:
s1, dispersing carboxymethyl chitosan in water to prepare a carboxymethyl chitosan solution with the mass percentage concentration of 2-3%, adding other raw materials into the carboxymethyl chitosan solution, and uniformly mixing to obtain a coating liquid;
and S2, coating the coating liquid obtained in the step S1 on base paper, and drying to obtain the white cardboard for medicine bags.
8. A method for preparing the ivory board for medicine package according to any of claims 5 to 6, characterized in that it comprises the following steps:
s1, dispersing carboxymethyl chitosan in water, and preparing a carboxymethyl chitosan solution with the mass percentage concentration of 2-3% to obtain a primary coating liquid;
s2, dissolving polylactic acid in a solvent to obtain a polylactic acid solution, and then dispersing microcrystalline cellulose, nano calcium carbonate and nano zinc oxide in the polylactic acid solution to obtain a secondary coating liquid;
s3, coating the primary coating liquid obtained in the step S1 on base paper and drying; then, the secondary coating liquid obtained in S2 was applied and dried to obtain a white cardboard for medicine bags.
9. The method for preparing a drug white cardboard according to claim 8, wherein the method comprises the following steps: the coating weight of the primary coating liquid is 4-5g/cm3, and the coating weight of the secondary coating liquid is 15-16g/cm 3.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674513A (en) * | 1996-02-20 | 1997-10-07 | Viro-Kote, Inc. | Anti-bacterial/anti-viral coatings, coating process and parameters thereof |
| CN110886132A (en) * | 2018-09-11 | 2020-03-17 | 友元办公联盟(天津)股份有限公司 | Mildew-proof antibacterial white cardboard and processing technology thereof |
| CN110886131A (en) * | 2018-09-11 | 2020-03-17 | 友元办公联盟(天津)股份有限公司 | Durable antibacterial white cardboard and preparation method thereof |
| CN112647357A (en) * | 2020-11-25 | 2021-04-13 | 江南大学 | Preparation method of waterproof, oil-proof and antibacterial packaging paperboard |
| CN112900149A (en) * | 2021-01-16 | 2021-06-04 | 北京金印联国际供应链管理有限公司 | White cardboard for food package and production process thereof |
| CN113388291A (en) * | 2021-06-02 | 2021-09-14 | 美盈森集团股份有限公司 | Antibacterial coating liquid, preparation method and antibacterial packaging coating method |
-
2022
- 2022-04-23 CN CN202210431885.5A patent/CN114837019A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674513A (en) * | 1996-02-20 | 1997-10-07 | Viro-Kote, Inc. | Anti-bacterial/anti-viral coatings, coating process and parameters thereof |
| CN110886132A (en) * | 2018-09-11 | 2020-03-17 | 友元办公联盟(天津)股份有限公司 | Mildew-proof antibacterial white cardboard and processing technology thereof |
| CN110886131A (en) * | 2018-09-11 | 2020-03-17 | 友元办公联盟(天津)股份有限公司 | Durable antibacterial white cardboard and preparation method thereof |
| CN112647357A (en) * | 2020-11-25 | 2021-04-13 | 江南大学 | Preparation method of waterproof, oil-proof and antibacterial packaging paperboard |
| CN112900149A (en) * | 2021-01-16 | 2021-06-04 | 北京金印联国际供应链管理有限公司 | White cardboard for food package and production process thereof |
| CN113388291A (en) * | 2021-06-02 | 2021-09-14 | 美盈森集团股份有限公司 | Antibacterial coating liquid, preparation method and antibacterial packaging coating method |
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