CN114835564A - Method for producing photoinitiator UV-1173 by condensation method - Google Patents
Method for producing photoinitiator UV-1173 by condensation method Download PDFInfo
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- CN114835564A CN114835564A CN202210420326.4A CN202210420326A CN114835564A CN 114835564 A CN114835564 A CN 114835564A CN 202210420326 A CN202210420326 A CN 202210420326A CN 114835564 A CN114835564 A CN 114835564A
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- isobutyrophenone
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- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 23
- 238000009833 condensation Methods 0.000 title claims abstract description 16
- 230000005494 condensation Effects 0.000 title claims abstract description 16
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims abstract description 72
- 239000003054 catalyst Substances 0.000 claims abstract description 68
- BSMGLVDZZMBWQB-UHFFFAOYSA-N 2-methyl-1-phenylpropan-1-one Chemical compound CC(C)C(=O)C1=CC=CC=C1 BSMGLVDZZMBWQB-UHFFFAOYSA-N 0.000 claims abstract description 64
- 239000002994 raw material Substances 0.000 claims abstract description 62
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 58
- 238000006482 condensation reaction Methods 0.000 claims abstract description 32
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 29
- 235000010233 benzoic acid Nutrition 0.000 claims abstract description 29
- 150000003839 salts Chemical class 0.000 claims abstract description 28
- 238000005660 chlorination reaction Methods 0.000 claims abstract description 22
- 238000005904 alkaline hydrolysis reaction Methods 0.000 claims abstract description 19
- 238000006243 chemical reaction Methods 0.000 claims description 35
- 239000011572 manganese Substances 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 19
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Substances CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 16
- 230000004913 activation Effects 0.000 claims description 14
- 239000011259 mixed solution Substances 0.000 claims description 14
- 101100513612 Microdochium nivale MnCO gene Proteins 0.000 claims description 12
- QMZIDZZDMPWRHM-UHFFFAOYSA-L manganese(2+);dibenzoate Chemical compound [Mn+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 QMZIDZZDMPWRHM-UHFFFAOYSA-L 0.000 claims description 11
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 239000012043 crude product Substances 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 7
- XMLYCEVDHLAQEL-UHFFFAOYSA-N 2-hydroxy-2-methyl-1-phenylpropan-1-one Chemical compound CC(C)(O)C(=O)C1=CC=CC=C1 XMLYCEVDHLAQEL-UHFFFAOYSA-N 0.000 claims description 6
- 238000004321 preservation Methods 0.000 claims description 6
- -1 MnCl Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 230000002194 synthesizing effect Effects 0.000 claims description 5
- 239000003513 alkali Substances 0.000 claims description 4
- UOGMEBQRZBEZQT-UHFFFAOYSA-L manganese(2+);diacetate Chemical compound [Mn+2].CC([O-])=O.CC([O-])=O UOGMEBQRZBEZQT-UHFFFAOYSA-L 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 239000007858 starting material Substances 0.000 claims description 4
- 239000002910 solid waste Substances 0.000 abstract description 9
- 239000000126 substance Substances 0.000 abstract description 8
- 238000002474 experimental method Methods 0.000 abstract description 5
- 239000013067 intermediate product Substances 0.000 abstract description 4
- 239000002699 waste material Substances 0.000 abstract description 4
- 230000009849 deactivation Effects 0.000 abstract description 3
- 239000000047 product Substances 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000003889 chemical engineering Methods 0.000 abstract description 2
- 238000010924 continuous production Methods 0.000 abstract description 2
- 239000012847 fine chemical Substances 0.000 abstract description 2
- FFSAXUULYPJSKH-UHFFFAOYSA-N butyrophenone Chemical compound CCCC(=O)C1=CC=CC=C1 FFSAXUULYPJSKH-UHFFFAOYSA-N 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 14
- 239000012071 phase Substances 0.000 description 12
- 239000002253 acid Substances 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 8
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- UYSVXJZQVNOLNB-UHFFFAOYSA-N 1-(4-tert-butylphenyl)-2-methylpropan-1-one Chemical compound CC(C)C(=O)C1=CC=C(C(C)(C)C)C=C1 UYSVXJZQVNOLNB-UHFFFAOYSA-N 0.000 description 5
- ZDFKSZDMHJHQHS-UHFFFAOYSA-N 2-tert-butylbenzoic acid Chemical compound CC(C)(C)C1=CC=CC=C1C(O)=O ZDFKSZDMHJHQHS-UHFFFAOYSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000000460 chlorine Substances 0.000 description 5
- 239000001569 carbon dioxide Substances 0.000 description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 description 4
- 230000003197 catalytic effect Effects 0.000 description 4
- VZFUCHSFHOYXIS-UHFFFAOYSA-N cycloheptane carboxylic acid Natural products OC(=O)C1CCCCCC1 VZFUCHSFHOYXIS-UHFFFAOYSA-N 0.000 description 4
- 238000010992 reflux Methods 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 4
- 238000005727 Friedel-Crafts reaction Methods 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- GJKGAPPUXSSCFI-UHFFFAOYSA-N 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone Chemical compound CC(C)(O)C(=O)C1=CC=C(OCCO)C=C1 GJKGAPPUXSSCFI-UHFFFAOYSA-N 0.000 description 2
- MQDJYUACMFCOFT-UHFFFAOYSA-N bis[2-(1-hydroxycyclohexyl)phenyl]methanone Chemical compound C=1C=CC=C(C(=O)C=2C(=CC=CC=2)C2(O)CCCCC2)C=1C1(O)CCCCC1 MQDJYUACMFCOFT-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- MNWFXJYAOYHMED-UHFFFAOYSA-N hexane carboxylic acid Natural products CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000005580 one pot reaction Methods 0.000 description 2
- 239000003444 phase transfer catalyst Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 2
- 239000002351 wastewater Substances 0.000 description 2
- JHXJMPVUVKIGKC-UHFFFAOYSA-N 1-(4-tert-butylphenyl)-2-hydroxy-2-methylpropan-1-one Chemical compound CC(C)(C)C1=CC=C(C(=O)C(C)(C)O)C=C1 JHXJMPVUVKIGKC-UHFFFAOYSA-N 0.000 description 1
- 239000012956 1-hydroxycyclohexylphenyl-ketone Substances 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 description 1
- 238000000016 photochemical curing Methods 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/584—Recycling of catalysts
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Abstract
The invention provides a method for producing a photoinitiator UV-1173 by a condensation method, belonging to the technical field of fine chemical engineering. Using benzoic acid and isobutyric acid as raw materials, in Mn 2+ In the presence of salt, condensation reaction is carried out at the temperature of 200-400 ℃ to generate an intermediate product of isobutyrophenone in one step, and then chlorination and alkaline hydrolysis are carried out on the isobutyrophenone to prepare the photoinitiator UV-1173. The method reduces the use of dangerous chemicals, reduces the output of three wastes, and is an environment-friendly production process. Experiments show that the yield of the isobutyrophenone can reach more than 97% (calculated according to benzoic acid). At the same time, with Mn 2+ The salt is used as a catalyst to realize continuous production, which is beneficial to prolonging the production period, and experiments show that 2.5kg of Mn 2+ Salt, 200kg of continuous feed, no catalyst deactivation was observed. 2000kg of Mn 2+ The isobutyrophenone 632t can be produced by continuously feeding the salt for 400 days. After the catalyst deactivation, about 4200kg of solid waste is produced, i.e. each ton of iso-product is producedThe butyrophenone only needs to generate 6.6kg of solid waste, so that the generation amount of the solid waste is greatly reduced.
Description
Technical Field
The invention belongs to the technical field of fine chemical engineering, and particularly relates to a method for producing a photoinitiator UV-1173 by a condensation method.
Background
The photoinitiator UV-1173 (2-hydroxy-2-methyl-1-phenyl-1-acetone) is a novel photoinitiator with excellent performance, has the advantages of high initiation efficiency, good thermal stability, yellowing resistance, no peculiar smell and the like, and has a prominent position in photocuring
The method is characterized in that isobutyric acid is used as a raw material, and 2-hydroxy-2-methyl-1-phenyl-1-acetone is prepared through acylation reaction, Friedel-crafts reaction, chlorination reaction and alkaline hydrolysis reaction in sequence, and is a main production method of a photoinitiator UV-1173. For example, chinese patent nos. 201110200666.8 and 201810893357.5 both describe the production of photoinitiator UV-1173 in a similar process.
However, the above process not only needs a large amount of dangerous chemicals such as phosphorus trichloride, aluminum trichloride, chlorine and the like, but also generates a large amount of three wastes such as high phosphorus wastewater, aluminum water generated by friedel-crafts hydrolysis, hydrogen chloride gas, hydrochloric acid wastewater and the like, and is not environment-friendly.
In order to overcome the problems, the invention of Chinese patent No. 201810727673.5 provides a preparation process of a photoinitiator 1173, which comprises the steps of taking benzoic acid and isobutyric acid as raw materials, dehydrating at high temperature and decarbonizing under the action of a metal salt catalyst to prepare isobutyrophenone, and then carrying out one-pot chlorination and alkaline hydrolysis reaction on the isobutyrophenone as an intermediate product, carbon tetrachloride and sodium hydroxide as reagents and tetrabutylammonium bromide as a phase transfer catalyst to prepare the 2-hydroxy-2-methyl-1-phenyl-1-acetone. Although the use of dangerous chemical substances is reduced and the generation amount of three wastes is reduced in the technical process, the reaction yield is low due to the selection influence of the catalyst and the reaction temperature, and the catalyst needs to be frequently replaced, so that the long-time stable production is not facilitated, and a large amount of solid wastes are generated.
Disclosure of Invention
Based on the above, the invention provides a method for producing the photoinitiator UV-1173 by a condensation method, which aims to solve the technical problems that the yield is low and the production cannot be stable for a long time when the photoinitiator UV-1173 is produced by taking benzoic acid and isobutyric acid as raw materials in the prior art.
The technical scheme for solving the technical problems is as follows:
a method for producing a photoinitiator UV-1173 by a condensation process, comprising the steps of:
s10, mixing isobutyric acid and benzoic acid to prepare a raw material mixed solution A, wherein the mass ratio of the isobutyric acid to the benzoic acid is 1 (0.6-1.0);
s20, contacting the raw material mixed liquor A with a catalyst, and carrying out condensation reaction at a first reaction temperature to generate isobutyrophenone; wherein the content of the first and second substances,catalyst is Mn 2+ One or more of a salt;
s30, synthesizing 2-hydroxy-2-methyl-1-phenyl-1-acetone by isobutyrophenone.
Preferably, in step S20, the step of contacting the raw material mixture a with a catalyst to perform a condensation reaction at a first reaction temperature to generate isobutyrophenone includes the steps of:
s21, catalyst activation stage: heating the raw material mixed solution A to an activation temperature, adding a catalyst, fully mixing, and keeping the temperature for a first time;
s22, condensation reaction stage: after the heat preservation is finished, dropwise adding the raw material mixed liquor A at a first reaction temperature to perform condensation reaction; condensing and collecting gas phase fraction to obtain a crude product B;
s23, a separation stage: the unreacted starting materials isobutyric acid and benzoic acid and isobutyrophenone were separated from crude B.
Preferably, the first reaction temperature is 200 ℃ to 400 ℃.
Preferably, in step S21, the activation temperature is 200 ℃ to 400 ℃.
Preferably, in step S22, after the completion of the heat-retaining, the raw material mixture A is dropped at a dropping rate of 40g/h to 75g/h per kg of the catalyst at the first reaction temperature to perform the condensation reaction.
Preferably, in step S21, the mass ratio of the catalyst to the raw material mixture A is 1 (1-1.5).
Preferably, in step S10, the mass ratio of isobutyric acid to benzoic acid is 1 (0.83-0.90).
Preferably, the catalyst is MnO, MnCl, Mn (NO) 3 ) 2 、MnSO 4 、MnCO 3 One or more of manganese (II) benzoate and manganese (II) acetate.
Preferably, in step S30, the "synthesis of 2-hydroxy-2-methyl-1-phenyl-1-propanone with isobutyrophenone" comprises the steps of: isobutyrophenone is used as a raw material, and the 2-hydroxy-2-methyl-1-phenyl-1-acetone is prepared through chlorination reaction and alkaline hydrolysis reaction.
Preferably, in step S30, the "synthesis of 2-hydroxy-2-methyl-1-phenyl-1-propanone with isobutyrophenone" comprises the steps of:
s31, chlorination reaction: introducing Cl into isobutyrophenone at a chlorination reaction temperature of 50-80 DEG C 2 Carrying out chlorination reaction to obtain chloroketone A;
s32, alkaline hydrolysis reaction: adding the chloroketone A into liquid alkali, and stirring for alkaline hydrolysis reaction.
Compared with the prior art, the invention has at least the following advantages:
using benzoic acid and isobutyric acid as raw materials, in Mn 2+ In the presence of salt, condensation reaction is carried out at the temperature of 200-400 ℃ to generate isobutyrophenone as an intermediate product in one step, and then chlorination and alkaline hydrolysis are carried out on the isobutyrophenone to prepare the 2-hydroxy-2-methyl-1-phenyl-1-acetone (namely the photoinitiator UV-1173). The method provided by the invention synthesizes isobutyrophenone by one-step method, reduces the use of dangerous chemicals and reduces the output of three wastes compared with a Friedel-crafts reaction process, and is an environment-friendly production process. With Mn 2+ Experiments show that the salt is used as a catalyst, the yield of the photoinitiator UV-1173 is favorably improved, and the yield of the UV-1173 can reach more than 90 percent (calculated according to benzoic acid). At the same time, with Mn 2+ The salt is used as a catalyst to realize continuous production, which is beneficial to prolonging the production period, and experiments show that 2.5kg of Mn 2+ Salt, 200kg of continuous feed, no catalyst deactivation was observed. The industrial production practice shows that 2000kg of Mn 2+ The isobutyrophenone 632t can be produced by continuously feeding the salt for 400 days. After the catalyst is deactivated, about 4200kg of solid waste is generated, namely only 6.6kg of solid waste needs to be generated for producing each ton of isobutyrophenone, so that the generation amount of the solid waste is greatly reduced.
Detailed Description
It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict. The technical solutions of the present invention will be further described below with reference to the following embodiments of the present invention, and the present invention is not limited to the following specific embodiments.
In one embodiment, a condensation process for producing photoinitiator UV-1173 comprises the steps of:
s10, mixing isobutyric acid and benzoic acid to prepare a raw material mixed solution A, wherein the mass ratio of the isobutyric acid to the benzoic acid is 1 (0.6-1.0).
Preferably, the mass ratio of isobutyric acid to benzoic acid is 1 (0.90 to 0.98), and the mass ratio of benzoic acid to isobutyric acid is 1 (1.25 to 1.35): that is, the isobutyric acid is in excess in the reaction raw material system.
S20, contacting the raw material mixed liquor A with a catalyst, and carrying out condensation reaction at a first reaction temperature to generate isobutyrophenone; wherein the catalyst is Mn 2+ One or more of salts.
Preferably, the first reaction temperature is 200 ℃ to 400 ℃, and further, the first reaction temperature is 280 ℃ to 320 ℃. The condensation reaction process is shown as formula I:
at 200-400 deg.C, adding Mn 2+ The salt acts as a catalyst, and benzoic acid and isobutyric acid react by condensation to form isobutyrophenone, and water and carbon dioxide are formed simultaneously. At high temperature, water and carbon dioxide are discharged out of the reaction system in a gas phase, which facilitates the reaction.
For example, catalyst Mn 2+ The salt can be MnO, MnCl, Mn (NO) 3 ) 2 、MnSO 4 、MnCO 3 One or more of manganese (II) benzoate and manganese (II) acetate. For example, catalyst Mn 2+ The salt may be MnO and MnCO 3 A mixture of (a). Preferably, Mn 2+ The salt may be manganese (II) benzoate.
Specifically, the above process includes the steps of:
s21, catalyst activation stage: heating the raw material mixed solution A to an activation temperature, adding a catalyst, fully mixing, and keeping the temperature for the first time.
In one embodiment, feed mixture a is first warmed to an activation temperature, for example, 200 ℃ to 400 ℃, condensed and the vapor phase collected to establish total reflux. Temperature riseAfter the target temperature, the catalyst Mn is added 2+ Preferably, the amount of the catalyst added is 1 to 1.5 times the mass of the raw material mixture A. Fully stirring to obtain the catalyst Mn 2+ Fully mixing the salt with the raw material mixture A, and keeping the temperature for 6-24 h.
S22, condensation reaction stage: after the heat preservation is finished, dropwise adding the raw material mixed liquor A at a first reaction temperature to perform condensation reaction; condensing and collecting gas phase fraction to obtain crude product B.
To catalyst Mn 2+ And (3) dropwise adding the raw material mixed liquor A into the reaction system after the salt heat preservation and activation are finished, and carrying out condensation reaction. Condensing and collecting gas phase fraction, returning part of the gas phase fraction as reflux liquid phase to the reaction system, and taking part of the gas phase fraction as crude product containing isobutyrophenone. Preferably, the first reaction temperature is 200 ℃ to 400 ℃. The raw material mixed liquor A is slowly dripped into the reaction system, and preferably, the raw material mixed liquor A is dripped at the dripping speed of 40g/h-75g/h per kg of catalyst to carry out condensation reaction. It is to be noted that the "dropping of the raw material mixture A at a dropping rate of 40g/h to 75g/h per kg of the catalyst" is to be understood as: if the catalyst content in the system is 1kg, the dropping speed of the raw material mixed liquor A is 40g/h-75 g/h; if the catalyst content in the system is 2kg, the dropping speed of the raw material mixed liquor A is 80g/h-150 g/h; if the catalyst content in the system is 1000kg, the dropping rate of the raw material mixed liquor A is 40kg/h-75kg/h, and so on.
S23, a separation stage: the unreacted starting materials isobutyric acid and benzoic acid and isobutyrophenone were separated from crude B.
For example, the raw material isobutyric acid and the intermediate product isobutyrophenone are separated from the crude product B by distillation, wherein the purity of the isobutyrophenone is more than or equal to 99%.
S30, synthesizing 2-hydroxy-2-methyl-1-phenyl-1-acetone by isobutyrophenone.
The 2-hydroxy-2-methyl-1-phenyl-1-acetone can be synthesized by taking isobutyrophenone as a raw material in various ways. For example, 2-hydroxy-2-methyl-1-phenyl-1-propanone can be prepared by performing one-pot chlorination and alkaline hydrolysis reactions on isobutyrophenone as a raw material in a system using carbon tetrachloride and sodium hydroxide as reagents and tetrabutylammonium bromide as a phase transfer catalyst as proposed in the Chinese invention patent with patent number 201810727673.5. Or the crude product of 2-hydroxy-2-methyl-1-phenyl-1-acetone can be prepared by chlorination reaction as described in Chinese invention patent No. 201810893357.5 to obtain chloroketone, and then by alkaline hydrolysis reaction.
Preferably, the "synthesis of 2-hydroxy-2-methyl-1-phenyl-1-propanone with isobutyrophenone" in step S30 comprises the steps of:
s31, chlorination reaction: introducing Cl into isobutyrophenone at a chlorination reaction temperature of 50-80 DEG C 2 And carrying out chlorination reaction to obtain the chloroketone A.
Introducing Cl into isobutyrophenone 2 And carrying out chlorination reaction to prepare the chloroketone A (chemical formula is shown as formula II). During the chlorination process, HCl and Cl are generated 2 The tail gas is absorbed by water to obtain a byproduct hydrochloric acid.
S32, alkaline hydrolysis reaction: adding the chloroketone A into liquid alkali, and stirring for carrying out alkaline hydrolysis reaction.
Adding the chloroketone A into liquid alkali (NaOH solution, 0.1M), stirring for carrying out alkaline hydrolysis reaction, and finishing the alkaline hydrolysis reaction when the content of the chloroketone A in the system is less than 0.2 percent. Adding water to wash the mixture to be neutral to obtain a crude product of the 2-hydroxy-2-methylphenyl propane-1-ketone.
The 2-hydroxy-2-methyl phenyl propane-1-ketone crude product is further processed by rectification and the like to obtain a finished product of 2-hydroxy-2-methyl phenyl propane-1-ketone with the purity of more than or equal to 95 percent, namely the photoinitiator UV-1173.
It should be noted that those skilled in the art will understand that the technical concept of the present invention can also be applied to the preparation of other α -hydroxy ketone photoinitiators, such as UV-184 (1-hydroxycyclohexyl phenyl ketone), UV-2959 (2-hydroxy-4' - (2-hydroxyethoxy) -2-methyl propiophenone), photoinitiator 185 (2-hydroxy-2-methyl-1- [4- (tert-butyl) phenyl)]-1-propanone). For example, with Mn 2+ Salt as catalyst, benzoic acid and ringThe hexanecarboxylic acid is used as a raw material for preparing 1-hydroxycyclohexyl phenyl ketone, and further preparing a photoinitiator UV-184.
For another example, a method of producing the photoinitiator 185 includes the steps of:
t10 mixing isobutyric acid and tert-butylbenzoic acid to prepare a raw material mixture A, wherein the mass ratio of isobutyric acid to tert-butylbenzoic acid is 1 (0.6-1.0).
Preferably, the mass ratio of isobutyric acid to t-butylbenzoic acid is 1 (0.83 to 0.90), that is, the raw material system of the reaction is such that isobutyric acid is in excess.
T20, contacting the raw material mixed liquor A with a catalyst, and carrying out condensation reaction at a first reaction temperature to generate 2-methyl-1- [4- (tert-butyl) phenyl]-1-propanone; wherein the catalyst is Mn 2+ One or more of salts.
Preferably, the first reaction temperature is 200 ℃ to 400 ℃, and further, the first reaction temperature is 280 ℃ to 320 ℃.
At 200-400 deg.C, adding Mn 2+ Condensation reaction of tert-butylbenzoic acid and isobutyric acid with salt as catalyst to produce 2-methyl-1- [4- (tert-butyl) phenyl]1-propanone with the concomitant formation of water and carbon dioxide. At high temperature, water and carbon dioxide are discharged out of the reaction system in a gas phase, which facilitates the reaction.
For example, catalyst Mn 2+ The salt can be MnO, MnCl, Mn (NO) 3 ) 2 、MnSO 4 、MnCO 3 One or more of manganese (II) benzoate and manganese (II) acetate. For example, catalyst Mn 2+ The salt may be MnO and MnCO 3 A mixture of (a). Preferably, Mn 2+ The salt may be manganese (II) benzoate.
Specifically, the above process includes the steps of:
t21. catalyst activation stage: heating the raw material mixed solution A to an activation temperature, adding a catalyst, fully mixing, and keeping the temperature for the first time.
In one embodiment, the temperature of the raw material mixture A is first raised to an activation temperature, for example, 200 deg.C to 40 deg.CThe gas phase was condensed and collected at 0 ℃ to establish total reflux. After the temperature is raised to the target temperature, catalyst Mn is added 2+ Preferably, the amount of the salt added is 1 to 1.5 times the mass of the raw material mixture A. Fully stirring to obtain the catalyst Mn 2+ Fully mixing the salt with the raw material mixture A, and keeping the temperature for 6-24 h.
T22. condensation reaction stage: after the heat preservation is finished, dropwise adding the raw material mixed liquor A at a first reaction temperature to perform condensation reaction; condensing and collecting gas phase fraction to obtain crude product B.
To catalyst Mn 2+ And (3) dropwise adding the raw material mixed liquor A into the reaction system after the salt heat preservation and activation are finished, and carrying out condensation reaction. Condensing to collect gas phase fraction, returning part of the gas phase fraction as reflux liquid phase to the reaction system, and collecting part of the gas phase fraction as 2-methyl-1- [4- (tert-butyl) phenyl group]-1-crude acetone. Preferably, the first reaction temperature is 200 ℃ to 400 ℃. The raw material mixed liquor A is slowly dripped into the reaction system, and preferably, the raw material mixed liquor A is dripped at the dripping speed of 40g/h-75g/h per kg of catalyst to carry out condensation reaction. It is to be noted that the "dropping of the raw material mixture A at a dropping rate of 40g/h to 75g/h per kg of the catalyst" is to be understood as: if the catalyst content in the system is 1kg, the dropping speed of the raw material mixed liquor A is 40g/h-75 g/h; if the catalyst content in the system is 2kg, the dropping speed of the raw material mixed liquor A is 80g/h-150 g/h; if the catalyst content in the system is 1000kg, the dropping rate of the raw material mixed liquor A is 40kg/h-75kg/h, and so on.
T23, separation stage: the unreacted starting materials isobutyric acid and tert-butylbenzoic acid and 2-methyl-1- [4- (tert-butyl) phenyl ] -1-propanone were separated from crude B.
For example, the starting isobutyric acid and the intermediate 2-methyl-1- [4- (tert-butyl) phenyl ] -1-propanone are separated from crude B by distillation.
T30 Synthesis of photoinitiator 185 (2-hydroxy-2-methyl-1- [4- (tert-butyl) phenyl ] -1-propanone) with 2-methyl-1- [4- (tert-butyl) phenyl ] -1-propanone.
The technical scheme and technical effects of the present invention are further described below by specific experimental examples.
Experimental example 1
Raw material mixed liquids A1, A2 and A3 were prepared respectively according to the mass ratios of 1.35:1, 1.25:1 and 1.15:1 of benzoic acid and isobutyric acid. 2.5kg of mixed acid and 2kg of catalyst MnO were added into the experimental tank reactor, stirred, heated and activated. And slowly raising the temperature, and when the temperature reaches 300 ℃, dropwise adding the prepared raw material mixed liquor A1, A2 and A3 into the experimental kettle-type reactor according to the dropwise adding flow of 100g/h to perform condensation reaction. And (3) condensing and collecting fractions generated by the condensation reaction through feeding of a condenser, collecting condensate for rectification, and recovering redundant cyclohexanecarboxylic acid until mixed acid is prepared and used, so as to obtain an intermediate isobutyrophenone with the content of more than 99%. The obtained isobutyrophenone is subjected to chlorination, alkaline hydrolysis and rectification to obtain the 2-hydroxy-2-methyl-1-phenyl-1-acetone photoinitiator.
The purity of the resulting isobutyrophenone (not rectified) was checked and the yield of isobutyrophenone was calculated as shown in table 1.
TABLE 1 purity and yield of isobutyrophenone obtained in Experimental example one
Serial number | Benzoic acid: isobutyric acid | Batch size of mixed acid | Weight of fraction | Purity of | Yield (calculated as benzoic acid) |
A1 | 1.35:1 | 200kg | 128.4kg | 98.2% | 90.37% |
A2 | 1.25:1 | 200kg | 132.1kg | 99.5% | 97.41% |
A3 | 1.15:1 | 200kg | 126.2kg | 99.2% | 96.36% |
As can be seen from Table 1, the purity of isobutyrophenone obtained by MnO catalysis can reach more than 99%, and the yield of isobutyrophenone can reach 96% when isobutyric acid is excessive. Meanwhile, the catalyst is continuously produced, and the high catalytic activity is still maintained until the total feeding amount is more than 200 kg.
Experimental example two
A raw material mixed solution A4 was prepared so that the mass ratio of benzoic acid to isobutyric acid was 1.25: 1. 2.5kg of mixed acid and 2kg of catalyst MnCO are taken 3 Adding into a kettle reactor for experiment, stirring, heating and activating. Slowly raising the temperature, and when the temperature reaches 320 ℃, dropwise adding the prepared raw material mixed solution A4 into the experimental kettle-type reactor according to the dropwise adding flow of 80g/h to perform condensation reaction. The fraction produced by the condensation reaction is condensed and collected by feeding through a condenser, the condensate is collected for rectification, and the redundant cyclohexanecarboxylic acid is recovered to be used in mixed acid preparation and application to obtain an intermediate isobutyrophenone containing isobutyrophenoneThe amount is more than 99%. The obtained isobutyrophenone is subjected to chlorination, alkaline hydrolysis and rectification to obtain the 2-hydroxy-2-methyl-1-phenyl-1-acetone photoinitiator.
The purity of the resulting isobutyrophenone (not rectified) was checked and the yield of isobutyrophenone was calculated as shown in table 2.
EXAMPLE III
A raw material mixed solution A4 was prepared so that the mass ratio of benzoic acid to isobutyric acid was 1.25: 1. 2.5kg of mixed acid and 2kg of manganese (II) benzoate as a catalyst are added into an experimental kettle-type reactor, and stirring, heating and activating are carried out. Slowly raising the temperature, and when the temperature reaches 280 ℃, dropwise adding the prepared raw material mixed solution A4 into the experimental kettle-type reactor according to the dropwise adding flow of 80g/h to perform condensation reaction. And (3) condensing and collecting fractions generated by the condensation reaction through feeding of a condenser, collecting condensate for rectification, and recovering redundant cyclohexanecarboxylic acid until mixed acid is prepared and used, so as to obtain an intermediate isobutyrophenone with the content of more than 99%. The obtained isobutyrophenone is subjected to chlorination, alkaline hydrolysis and rectification to obtain the 2-hydroxy-2-methyl-1-phenyl-1-acetone photoinitiator.
The purity of the resulting isobutyrophenone (not rectified) was checked and the yield of isobutyrophenone was calculated as shown in table 2.
TABLE 2 purity and yield of isobutyrophenone obtained in Experimental examples II and III
Serial number | Benzoic acid: isobutyric acid | Batch size of mixed acid | Weight of fraction | Purity of | Yield (calculated as benzoic acid) |
A4 | 1.25:1 | 200kg | 133.7kg | 99.4% | 97.58% |
A4 | 1.25:1 | 200kg | 134.3kg | 99.0% | 97.23% |
As can be seen from Table 2, MnCO 3 The purity of the obtained isobutyrophenone can reach more than 99% under the catalytic action of manganese (II) benzoate, the yield of the isobutyrophenone can reach more than 97% when isobutyric acid is excessive, and particularly, the yield of the isobutyrophenone can reach more than 97% under the catalytic action of manganese (II) benzoate. Meanwhile, the catalyst is continuously produced, and the high catalytic activity is still maintained until the total feeding amount is more than 200 kg.
Experimental example four
A raw material mixed solution A4 was prepared so that the mass ratio of benzoic acid to isobutyric acid was 1.25: 1. 2500kg of mixed acid and 2000kg of catalyst MnO (G1) and MnCO are taken 3 (G2) Manganese (II) benzoate (G3), MnO and MnCO 3 Was added (ratio of amounts of substances 1:1) (G4) to a volume of 10m 3 Stirring, heating and activating the reaction product in the tank reactor. Slowly raising the temperature, and when the temperature reaches 300 ℃, dropwise adding the prepared raw material mixed solution A4 into the experimental kettle-type reactor according to the dropwise adding flow of 100kg/h to perform condensation reaction. The fraction produced by the condensation reaction is fed, condensed and collected by a condenser, and the condensate is collected for refiningAnd (4) distilling, and recovering redundant cyclohexanecarboxylic acid to be used together with mixed acid to obtain an intermediate isobutyrophenone with the content of more than 99%.
When the catalyst activity was significantly decreased (the content of isobutyrophenone in the produced condensate was decreased), the number of days for continuous stable operation of the apparatus, the total amount of isobutyrophenone produced and the amount of residue at the bottom of the reaction vessel were counted, and the amount of solid waste produced per unit mass of isobutyrophenone was calculated, as shown in table 3.
TABLE 3 statistical results of Experimental example four
Batch number | Catalyst feeding | Run time | Produce isobutyrophenone | Residual amount of the kettle | Residual amount of the product per ton |
G1 | 2000kg | 404 days | 632 ton (ton) | 4200kg | 6.6kg |
G2 | 2000kg | 452 days | 780 ton (ton) | 4150kg | 5.3kg |
G3 | 2000kg | 420 days | 720 ton of the rotary kiln | 3820kg | 5.3kg |
G4 | 2000kg | 512 days | 825 ton (ton) | 4230kg | 5.1kg |
As can be seen from Table 3, the composition is characterized by MnO (G1) and MnCO 3 (G2) Manganese (II) benzoate (G3), MnO and MnCO 3 The mixture (the mass ratio of the substances is 1:1) (G4) is used as a catalyst for industrial scale-up production, the activity of the catalyst can maintain the continuous and stable operation of the tank reactor for more than 400 days, the mass of solid waste generated by producing each ton of isobutyrophenone is only 5.1kg-6.6kg, and the method is an environment-friendly production process.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A method for producing a photoinitiator UV-1173 by a condensation method, which is characterized by comprising the following steps:
s10, mixing isobutyric acid and benzoic acid to prepare a raw material mixed solution A, wherein the mass ratio of the isobutyric acid to the benzoic acid is 1 (0.6-1.0);
s20, contacting the raw material mixed liquor A with a catalyst, and carrying out condensation reaction at a first reaction temperature to generate isobutyrophenone; wherein the catalyst is Mn 2+ One or more of a salt;
s30, synthesizing 2-hydroxy-2-methyl-1-phenyl-1-acetone by isobutyrophenone.
2. The method for producing the photoinitiator UV-1173 according to the condensation method of claim 1, wherein the step S20, wherein the step of contacting the raw material mixture A with the catalyst to perform condensation reaction at the first reaction temperature to generate isobutyrophenone comprises the steps of:
s21, catalyst activation stage: heating the raw material mixed solution A to an activation temperature, adding a catalyst, fully mixing, and keeping the temperature for a first time;
s22, condensation reaction stage: after the heat preservation is finished, dropwise adding the raw material mixed liquor A at a first reaction temperature to perform condensation reaction; condensing and collecting gas phase fraction to obtain a crude product B;
s23, a separation stage: the unreacted starting materials isobutyric acid and benzoic acid and isobutyrophenone were separated from crude B.
3. The method of condensation to produce photoinitiator UV-1173 according to claim 1 or 2, characterized in that the first reaction temperature is between 200 ℃ and 400 ℃.
4. The method for producing the photoinitiator UV-1173 according to claim 2, wherein the activation temperature is 200 ℃ to 400 ℃ in step S21.
5. The method for producing the photoinitiator UV-1173 according to the condensation method of claim 2, wherein in the step S22, after the completion of the heat-keeping, the raw material mixture A is added dropwise at a rate of 40g/h to 75g/h per kg of the catalyst at the first reaction temperature to perform the condensation reaction.
6. The method for producing the photoinitiator UV-1173 according to the condensation method of claim 2, wherein in the step S21, the mass ratio of the catalyst to the raw material mixed solution A is 1 (1-1.5).
7. The method of claim 1 for producing photoinitiator UV-1173, wherein in step S10, the mass ratio of isobutyric acid to benzoic acid is 1 (0.83-0.90).
8. The method of condensation to produce photoinitiator UV-1173 as claimed in claim 1 wherein the catalyst is MnO, MnCl, Mn (NO) 3 ) 2 、MnSO 4 、MnCO 3 One or more of manganese (II) benzoate and manganese (II) acetate.
9. The method for producing the photoinitiator UV-1173 according to the condensation method of any one of claims 1 to 7, wherein the step S30 of synthesizing 2-hydroxy-2-methyl-1-phenyl-1-propanone from isobutyrophenone comprises the steps of: isobutyrophenone is used as a raw material, and the 2-hydroxy-2-methyl-1-phenyl-1-acetone is prepared through chlorination reaction and alkaline hydrolysis reaction.
10. The method for producing the photoinitiator UV-1173 according to the condensation method of claim 9, wherein the step S30 of synthesizing 2-hydroxy-2-methyl-1-phenyl-1-propanone with isobutyrophenone comprises the steps of:
s31, chlorination reaction: introducing Cl into isobutyrophenone at a chlorination reaction temperature of 50-80 DEG C 2 Carrying out chlorination reaction to obtain chloroketone A;
s32, alkaline hydrolysis reaction: adding the chloroketone A into liquid alkali, and stirring for alkaline hydrolysis reaction.
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