CN114832244A - Single-channel radioactive particle source distribution method and three-dimensional construction method - Google Patents
Single-channel radioactive particle source distribution method and three-dimensional construction method Download PDFInfo
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- 239000002245 particle Substances 0.000 title claims abstract description 90
- 230000002285 radioactive effect Effects 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 title claims abstract description 48
- 238000010276 construction Methods 0.000 title claims abstract description 10
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 45
- 238000002513 implantation Methods 0.000 claims abstract description 24
- 208000014674 injury Diseases 0.000 claims description 8
- 230000008733 trauma Effects 0.000 claims description 7
- 238000012937 correction Methods 0.000 claims description 3
- 238000003709 image segmentation Methods 0.000 claims description 3
- 238000004088 simulation Methods 0.000 claims description 3
- 239000004744 fabric Substances 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002727 particle therapy Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1007—Arrangements or means for the introduction of sources into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1024—Seeds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
- A61N2005/1055—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using magnetic resonance imaging [MRI]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
- A61N2005/1061—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
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Abstract
The invention discloses a radioactive particle single-channel source distribution method and a three-dimensional construction method. Firstly, selecting a proper puncture point, and puncturing a hollow angle guide needle sheath to the surface of a target tumor focus through image guidance to establish a particle implantation channel; inserting a particle implantation needle into the angle guiding needle sheath to reach the tumor focus, and uniformly implanting particles at a certain interval by a particle implantation gun; rotating the angle and guiding the needle sheath to a certain angle, repeating the operation, thereby implanting multiple rows of particles in the tumor according to the distribution line. The invention simulates a clinical puncture method and provides a three-dimensional space-based source distribution method, and because only one puncture path from skin to the surface of a tumor exists, the number of the puncture paths outside the tumor can be effectively reduced, the wound brought to a patient is smaller, and the probability of causing complications is greatly reduced.
Description
Technical Field
The invention belongs to the technical field of radioactive particle source distribution methods, and particularly relates to a radioactive particle single-channel source distribution method and a three-dimensional construction method.
Background
The conventional radiotherapy for malignant tumors has low treatment precision, overlarge treatment range and great damage to normal tissues due to the lagging influence on diagnosis and positioning technologies, thereby bringing great pain to patients. The radioactive particle tissue implantation is that radioactive particles with short half-life period and weak radiation are implanted into the tumor through a particle implantation gun, and the apoptosis of tumor cells is caused by X rays or gamma rays continuously released by a radioactive source, so that the purpose of treatment is achieved. The method can be used for treating most solid tumors and malignant tumors. Compared with conventional radiotherapy, the radioactive particle tissue-tissue implantation has the advantages of minimally invasive, pollution-free radiation, high safety coefficient, high tumor local dose, small systemic radioactive damage and the like, and can effectively reduce the recurrence rate. Therefore, in recent years, the use of the radioactive particle tissue-to-tissue implantation has been widely used for the treatment of malignant tumors.
In order to improve the radiation therapy accuracy, some systems, such as a radioactive particle therapy Planning System (Treatment Planning System for brachythcher), are used before the radioactive particle implantation operation is performed
apy, TPSB) was designed for a puncture source solution. The prior art methods for distributing the source include linear distribution, 2D distribution, conical distribution, fan distribution, and the like. The schematic diagram of the fan-shaped source distribution method is shown in fig. 1. Compared with other source distribution methods in the prior art, the fan-shaped source distribution method can effectively reduce the number of needle insertion points and reduce the trauma to the patient in the operation. The fan-shaped cloth source only has one cloth source starting point, namely the needle entering point, so that compared with the cloth source scheme with more needle entering points in the prior art, the cloth source has the advantage that the wound of a patient is reduced to a certain extent. However, the fan-shaped source distribution method still needs a plurality of source distribution end points to perform multi-needle puncture, so that the radiation superposition range of the arranged radioactive particles can cover the whole tumor. More puncture paths mean greater trauma to the human body and greater risk of damage to normal tissues and organs of the human body.
Disclosure of Invention
The invention provides a radioactive particle single-channel source distribution method and a three-dimensional construction method in order to overcome the defects in the prior art.
The invention is realized by the following technical scheme: the invention discloses a radioactive particle single-channel source distribution method, which completes the implantation of all particles through a puncture path, and reduces the trauma to the human body in the operation process;
the single-channel radioactive particle source distribution method specifically comprises the following steps:
(1) firstly, selecting a proper puncture point, and puncturing a hollow angle guiding needle sheath to the surface of a target tumor focus through image guidance to establish a particle implantation channel;
(2) inserting a particle implantation needle into the angle guiding needle sheath to reach the tumor focus, and uniformly implanting particles at a certain interval by a particle implantation gun;
(3) rotating the angle to guide the needle sheath to a certain angle, and repeating the step (2), thereby implanting multiple rows of particles in the tumor according to the distribution line.
As a preferred embodiment of the present invention, in the step (2), the particles are uniformly implanted by the particle implantation gun at a pitch of 0.5cm to 1 cm.
The invention also discloses a three-dimensional construction method of the radioactive particle single-channel source distribution, which specifically comprises the following operation steps:
(1) Selecting a tumor region of interest: importing image data of CT or MRI image examination into a computer, selecting an interested tumor region by a doctor, and generating a three-dimensional image of the tumor by a system through image segmentation and manual correction;
(2) setting distribution parameters: setting the attribute of radioactive particles, the distance between the radioactive particles and the tumor edge;
(3) setting a puncture starting point: appointing a puncture starting point through the positioning view, adding the position into the puncture starting point list, and conveniently and directly selecting the point from the list as the puncture starting point next time;
(4) setting a puncture terminal: appointing a puncture terminal point through the positioning view, and adding the position into a puncture terminal point list, so that the point can be conveniently and directly selected from the list as the puncture terminal point next time;
(5) and displaying a puncture path: after a puncture starting point and a puncture end point are selected, the system displays a puncture path from the starting point to the end point;
(6) setting a rotation angle, generating a distribution line and particle distribution result: the puncture path can be rotated through the positioning view, the distribution line at the angle is automatically displayed by the system according to the determination when the puncture path is rotated to the desired angle, and radioactive particles are automatically distributed on the distribution line according to the distribution parameters set in the step (2);
(7) Displaying the particle, the distribution line and the isodose curve: and calculating and superposing dose distribution in the three-dimensional space for all the well-distributed radioactive particles according to the dose distribution model of the radioactive particles so as to display the influence of rays on the tumor and surrounding tissues.
And (4) when the puncture starting point is set in the step (3), the puncture starting point is displayed in the positioning view at the same time.
And (4) when the puncture terminal point is set, simultaneously displaying the puncture terminal point in the positioning view.
And (5) repeating the operation in the step (6) to further obtain the particle layout simulation results of all the layout lines.
The invention has the beneficial effects that: the invention provides a novel radioactive particle single-channel source distribution method and a three-dimensional construction method, and the problems that the existing radioactive particle source distribution methods in the prior art, such as linear source distribution methods, 2D source distribution methods, fan-shaped source distribution methods, conical source distribution methods and the like, are poor in source distribution precision, large in wound to patients and the like exist. The radioactive particle single-channel source distribution scheme based on the three-dimensional space aims to complete the implantation of all particles through one puncture path, so that the injury to a human body in the operation process is further reduced.
Compared with the commonly used fan-shaped source distribution in the prior art, the source distribution method only needs one puncture, firstly, the angle guide needle sheath is punctured to the surface position of a focus from a needle entering point, and then, when the radioactive particle source distribution is carried out, the angle of the source distribution line is adjusted by guiding the needle sheath through the rotation angle. Because only one puncture path from the skin to the surface of the tumor is provided, the trauma to the patient is smaller, and the probability of causing complications is greatly reduced. Compared with the prior art, the invention has the following advantages: (1) based on the source distribution scheme of the invention, the number of puncture paths outside the tumor can be effectively reduced, thereby reducing the trauma to the patient in the operation. (2) The invention provides a radioactive particle single-channel source distribution method based on a three-dimensional space, which simulates a clinical puncture method and enables a TPSB (tire pressure monitoring system) to distribute sources in the three-dimensional space in a manner similar to that of clinical actual puncture, so that the puncture efficiency and the source distribution precision in the actual puncture process are improved, and the treatment effect of a patient is improved. (3) The invention simulates the source distribution in the three-dimensional space, and can distribute the source in the selected tumor area according to the given distance by defining the puncture starting point and the puncture terminal point in the three-dimensional space and setting the angle of the needle sheath, thereby improving the puncture efficiency and the source distribution precision in the actual puncture process.
Drawings
FIG. 1 is a schematic diagram of a prior art fan-shaped source distribution method;
FIG. 2 is a schematic diagram of the single-channel radioactive particle source distribution method of the present invention:
FIG. 3 is a perspective view of the single-channel radioactive particle distribution method of the present invention;
fig. 4 is a schematic operation flow chart of the single-channel radioactive particle source distribution method of the present invention.
In the figure: 1-a tumor; 2-puncture point; 3-laying source lines; 4-particles; 5-the particle implantation channel.
Detailed Description
The invention is described in detail below with reference to the figures and the detailed description.
As shown in fig. 2 to 3, the invention discloses a radioactive particle single-channel source distribution method, which completes the implantation of all the particles 4 through a puncture path, and reduces the trauma to the human body in the operation process; the single-channel radioactive particle source distribution method specifically comprises the following steps: (1) firstly, selecting a proper puncture point 2, and puncturing a hollow angle guiding needle sheath to the surface of a focus of a target tumor 1 through image guidance to establish a particle implantation channel 5; (2) inserting a particle implantation needle into the angle guiding needle sheath to reach the focus of the tumor 1, and uniformly implanting particles 4 by a particle implantation gun according to the interval of 0.5 cm-1 cm; (3) rotating the angle to guide the needle sheath to a certain angle, repeating step (2), thereby implanting a plurality of rows of particles 4 in the tumor 1 according to the distribution line 3.
The invention also discloses a three-dimensional construction method of the radioactive particle single-channel source distribution, which specifically comprises the following operation steps: (1) selecting a tumor region of interest: importing image data of CT or MRI image examination into a computer, selecting an interested tumor region by a doctor, and generating a three-dimensional image of the tumor 1 by a system through image segmentation and manual correction; (2) setting cloth source parameters: setting the attribute of radioactive particles, the distance between the radioactive particles and the edge of the tumor 1; (3) setting a puncture starting point: appointing a puncture starting point through the positioning view, adding the position into the puncture starting point list, conveniently and directly selecting the point from the list as the puncture starting point next time, and simultaneously displaying the puncture starting point in the positioning view; (4) setting a puncture terminal: appointing a puncture terminal point through the positioning view, adding the position into a puncture terminal point list, conveniently and directly selecting the point from the list as the puncture terminal point next time, and simultaneously displaying the puncture terminal point in the positioning view; (5) and displaying a puncture path: after a puncture starting point and a puncture end point are selected, the system displays a puncture path from the starting point to the end point; (6) setting a rotation angle, generating a result of laying the source lines 3 and the particles 4: the puncture path can be rotated through the positioning view, the distribution line 3 under the angle is automatically displayed by the system according to the determination when the puncture path is rotated to the desired angle, and the radioactive particles 4 are automatically distributed on the distribution line 3 according to the distribution parameters set in the step (2); repeating the above operations to obtain the particle layout simulation results of all the layout lines 3; (7) particle 4, layout line 3 and isodose curves are shown: for all the deployed radioactive particles 4, the dose distribution in the three-dimensional space is calculated and superimposed according to the dose distribution model thereof to show the influence of the radioactive particles 4 on the tumor 1 and the surrounding tissues.
Fig. 4 is a schematic view of an operation flow of the single-channel tapered radioactive particle source distribution method of the present invention, and as shown in fig. 4, a tumor 1 is selected first, source distribution parameters are set, new puncture start points are added according to the number of tumors 1, then new puncture end points are added, so as to generate a puncture path, a needle warp rotation angle is set, particles 4 are automatically distributed according to the source distribution parameter setting, the needle warp rotation angle is repeatedly set for a plurality of times, so that a plurality of rows of particles 4 are implanted in the tumor 1 according to a plurality of source distribution lines 3, and the source distribution is completed. And after the puncture path is generated, if a new tumor exists, the tumor selecting step is started again, and the source distribution is carried out on the new tumor. If the original tumor is subjected to source distribution, a puncture starting point and a puncture end point are reselected or the existing puncture starting point and puncture end point are selected on the original tumor, a puncture path is generated, and the particles 4 are distributed.
Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.
Claims (6)
1. A radioactive particle single-channel source distribution method is characterized in that: the radioactive particle single-channel source distribution method completes the implantation of all the particles through a puncture path, and reduces the trauma to the human body in the operation process;
The radioactive particle single-channel source distribution method specifically comprises the following steps:
(1) firstly, selecting a proper puncture point, and puncturing a hollow angle guiding needle sheath to the surface of a target tumor focus through image guidance to establish a particle implantation channel;
(2) inserting a particle implantation needle into the angle guiding needle sheath to reach the tumor focus, and uniformly implanting particles at a certain interval by a particle implantation gun;
(3) rotating the angle to guide the needle sheath to a certain angle, and repeating the step (2), thereby implanting multiple rows of particles in the tumor according to the distribution line.
2. The single-channel radioactive particle source distribution method of claim 1, wherein: in the step (2), the particles are uniformly implanted by a particle implantation gun according to the distance of 0.5 cm-1 cm.
3. The three-dimensional construction method of radioactive-particle single-channel source distribution according to claim 1 or 2, characterized in that: the three-dimensional construction method specifically comprises the following operation steps:
(1) selecting a tumor region of interest:
importing image data of CT or MRI image examination into a computer, selecting an interested tumor region by a doctor, and generating a three-dimensional image of the tumor by a system through image segmentation and manual correction;
(2) Setting distribution parameters:
setting the attribute of radioactive particles, the distance between the radioactive particles and the tumor edge;
(3) setting a puncture starting point:
appointing a puncture starting point through the positioning view, adding the position into the puncture starting point list, and conveniently and directly selecting the point from the list as the puncture starting point next time;
(4) setting a puncture terminal:
appointing a puncture terminal point through the positioning view, and adding the position into a puncture terminal point list, so that the point can be conveniently and directly selected from the list as the puncture terminal point next time;
(5) and displaying a puncture path:
after a puncture starting point and a puncture end point are selected, the system displays a puncture path from the starting point to the end point;
(6) setting a rotation angle, generating a distribution line and particle distribution result:
the puncture path can be rotated through the positioning view, the distribution line at the angle is automatically displayed by the system according to the determination when the puncture path is rotated to the desired angle, and radioactive particles are automatically distributed on the distribution line according to the distribution parameters set in the step (2);
(7) displaying particle, layout line and isodose curves:
and calculating and superposing dose distribution in the three-dimensional space for all the well-distributed radioactive particles according to the dose distribution model of the radioactive particles so as to display the influence of rays on the tumor and surrounding tissues.
4. The method of claim 3, wherein the method comprises the following steps: and (4) when the puncture starting point is set in the step (3), the puncture starting point is displayed in the positioning view at the same time.
5. The method of claim 3, wherein the method comprises the following steps: and (4) when the puncture terminal point is set in the step (4), the puncture terminal point is displayed in the positioning view at the same time.
6. The method of claim 3, wherein the method comprises the following steps: and (4) repeating the operation in the step (6) to further obtain the particle layout simulation results of all the layout lines.
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