CN114831697A - Shock wave generating device for molding internal cavity - Google Patents
Shock wave generating device for molding internal cavity Download PDFInfo
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- CN114831697A CN114831697A CN202210554513.1A CN202210554513A CN114831697A CN 114831697 A CN114831697 A CN 114831697A CN 202210554513 A CN202210554513 A CN 202210554513A CN 114831697 A CN114831697 A CN 114831697A
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- 238000000465 moulding Methods 0.000 title description 4
- 239000007788 liquid Substances 0.000 claims abstract description 35
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 29
- 230000001681 protective effect Effects 0.000 claims abstract description 23
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- 238000007493 shaping process Methods 0.000 claims abstract description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 2
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- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
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- A61B2017/22001—Angioplasty, e.g. PCTA
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- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
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- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
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- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
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- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
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- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
Abstract
The invention provides a shock wave generating device for shaping a body cavity, which belongs to the field of medical instruments and comprises: the device comprises a carrier, a first inner electrode, a second inner electrode, an insulating protective sleeve and a balloon; the first internal electrode and the second internal electrode are respectively arranged on two opposite sides of the outer surface of the carrier; the first inner electrode and the second inner electrode are connected with an external power supply through leads; the saccule is wrapped on the carrier, a closed space is formed between the saccule and the carrier, liquid is filled in the closed space, and the two inner electrodes are positioned in the closed space; the insulating protective sleeve is sleeved on the carrier and covers the two inner electrodes; the insulating protective sleeve is provided with an opening or a slit to expose two partial inner electrodes, when the shock wave generating device acts on a human blood vessel, under the action of an external power supply, the first inner electrode is conducted with the second inner electrode through liquid, so that shock wave energy is generated in the balloon, calcified tissues at corresponding positions in a broken blood vessel are further broken, and the breaking efficiency of the calcified tissues is improved.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a shock wave generating device for shaping a body cavity.
Background
Coronary atherosclerotic heart disease is characterized by coronary artery angiogenesis and atherosclerotic lesion, resulting in stenosis or obstruction of blood vessel lumen, myocardial ischemia, anoxia or necrosis, also known as coronary heart disease. Generally, medication, intervention and surgery are used. The interventional therapy is remarkable in curative effect, small in wound, less in pain of patients, the total curative effect of the interventional therapy is the same as that of coronary artery bypass grafting, and the interventional therapy is obviously superior to simple drug therapy, and the technology is favored by clinicians and patients.
In 1977, Gruentzig successfully performed the first balloon angioplasty (PTCA) procedure in the world with a balloon catheter for a patient with a stenosis in the anterior descending proximal coronary artery, and initiated a new era of coronary intervention. Over ten years, the technology of the saccule support is rapidly developed, the saccule support becomes smaller in size and stronger in expansion force, and meanwhile, certain clinical experience is accumulated.
Most balloon catheters developed devices for achieving vasodilation currently available to shockwave companies, and the proposal of patent application No. 201380041656.1 provides a low profile electrode for an angioplasty shockwave catheter, wherein a first inner electrode is located at a first lateral position of an elongate member within the balloon, a second inner electrode is located at a second lateral position circumferentially offset from the first inner electrode, an insulating protective sheath is disposed around the first inner electrode and the second inner electrode, and an outer electrode protective sheath is disposed around the insulating protective sheath, and upon application of a voltage between the first inner electrode and the second inner electrode, current flows in sequence from the first inner electrode to the outer electrode protective sheath to the second inner electrode such that a first shockwave is initiated from the first lateral position and a second shockwave is initiated from the second lateral position. This scheme need set up outer electrode protective sheath, and the direction of electric current can only flow to outer electrode protective sheath from first inner electrode, arrives the second inner electrode again for the process that shock wave takes place is comparatively complicated, influences the crushing efficiency of calcification tissue.
In view of the above problems, there is a need for a new device for shaping the lumen of the body to remove calcified tissue from the intima of the blood vessel and to increase the efficiency of the disruption of the calcified tissue.
Disclosure of Invention
The invention aims to provide a shock wave generating device for shaping a body lumen, which can effectively crush calcified tissues in a blood vessel and improve the crushing efficiency of the calcified tissues.
In order to achieve the purpose, the invention provides the following scheme:
a shock wave generating device for molding of a body lumen, the shock wave generating device for molding of a body lumen comprising: the device comprises a carrier, a first inner electrode, a second inner electrode, an insulating protective sleeve and a balloon;
the first internal electrode and the second internal electrode are respectively arranged on two opposite sides of the outer surface of the carrier; the first internal electrode is connected with an external power supply through a first lead, and the second internal electrode is connected with the external power supply through a second lead;
the saccule is wrapped on the carrier, a closed space is formed between the saccule and the carrier, the first inner electrode and the second inner electrode are positioned in the closed space, and liquid is filled in the closed space;
the insulating protective sleeve is sleeved on the carrier and covers the first inner electrode and the second inner electrode; an opening or a slit is arranged on the insulating protective sleeve to expose part of the first internal electrode and part of the second internal electrode.
Optionally, the carrier is a catheter.
Optionally, the first internal electrode is a positive electrode and the second internal electrode is a negative electrode; when the shock wave generating device acts on a blood vessel of a human body, the first inner electrode is communicated with the second inner electrode through liquid under the action of an external power supply, and the liquid generates bubbles, so that shock wave energy is generated in the balloon.
Optionally, the number of the first internal electrodes is multiple, each first internal electrode is a positive electrode, and the second internal electrode is a negative electrode; when the shock wave generating device acts on the blood vessel of a human body, under the action of an external power supply, each first inner electrode is communicated with each second inner electrode through liquid, and the liquid generates bubbles, so that shock wave energy is generated in the saccule.
Optionally, the first internal electrodes are positive electrodes, the number of the second internal electrodes is multiple, and each second internal electrode is a negative electrode; when the shock wave generating device acts on the blood vessel of a human body, the first inner electrode is communicated with the second inner electrodes through liquid under the action of an external power supply, and the liquid generates bubbles, so that shock wave energy is generated in the saccule.
Optionally, the number of the first internal electrodes is multiple, and the number of the second internal electrodes is multiple; each first internal electrode is a positive electrode, and each second internal electrode is a negative electrode; a first internal electrode and a second internal electrode are arranged correspondingly; the first and second internal electrodes are arranged in a group.
Optionally, each group of electrodes has an angular difference with an adjacent group of electrodes in a central axis direction of the carrier to realize spiral discharge.
Optionally, the liquid in the closed space is a mixed liquid of a developing solution and a physiological saline.
Optionally, the balloon is provided with a plurality of micropores.
According to the specific embodiment provided by the invention, the invention discloses the following technical effects:
the first internal electrode and the second internal electrode are respectively arranged on two opposite sides of the outer surface of the carrier; the first internal electrode and the second internal electrode are connected with an external power supply through leads; the saccule is wrapped on the carrier, a closed space is formed between the saccule and the carrier, the first internal electrode and the second internal electrode are positioned in the closed space, and the closed space is filled with liquid; when the shock wave generating device acts on the blood vessel of a human body, the first inner electrode is communicated with the second inner electrode through liquid under the action of an external power supply, and the liquid generates bubbles, so that shock wave energy is generated in the balloon, and calcified tissues at corresponding positions in the blood vessel are broken. The first inner electrode and the second inner electrode are arranged on two opposite sides of the outer surface of the carrier, so that the balloon expansion efficiency is improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive exercise.
FIG. 1 is a schematic structural view of example 1 of the present invention;
FIG. 2 is another schematic structural view of embodiment 1 of the present invention;
FIG. 3 is a schematic structural view of example 2 of the present invention;
FIG. 4 is a schematic structural diagram of embodiment 3 of the present invention;
FIG. 5 is a schematic structural view of example 4 of the present invention;
fig. 6 is a schematic structural diagram of embodiment 5 of the present invention.
Description of the symbols:
the electrode comprises a carrier-1, a first internal electrode-2, a second internal electrode-3, a balloon-4, a first lead-5, a second lead-6, an insulating protective sleeve-7 and an opening-8.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
When the shock wave generating device acts on a human body blood vessel, under the action of an external power supply, the first inner electrode is communicated with the second inner electrode through liquid, and the liquid generates bubbles, so that shock wave energy is generated in the balloon to break calcified tissues at corresponding positions in the blood vessel, and the first inner electrode and the second inner electrode are arranged on two opposite sides of the outer surface of the carrier, so that the breaking efficiency of the calcified tissues is improved.
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.
Example 1
As shown in FIG. 1, the shock wave generator for shaping the body lumen of the present invention comprises: carrier 1, first inner electrode 2, second inner electrode 3 and sacculus 4.
Wherein the first and second internal electrodes 2 and 3 are respectively disposed on opposite sides of the outer surface of the carrier 1. The first inner electrode 2 is connected to an external power source through a first lead 5, and the second inner electrode 3 is connected to the external power source through a second lead 6. The first conductor 5 and the second conductor 6 each extend outwardly along the carrier 1.
In particular, the carrier 1 is a catheter. The material of the carrier 1 is an insulating material.
The sacculus 4 wraps the carrier 1, a closed space is formed between the sacculus 4 and the carrier 1, the first inner electrode 2 and the second inner electrode 3 are located in the closed space, and liquid is filled in the closed space. Specifically, the liquid in the closed space is a mixed liquid of a developing solution and normal saline.
When the shock wave generating device acts on a blood vessel of a human body, under the action of an external power supply, the first inner electrode 2 is communicated with the second inner electrode 3 through liquid, and the liquid generates bubbles, so that shock wave energy is generated in the balloon 4. The calcified tissues at the corresponding positions in the blood vessel can be quickly broken.
In order to further improve the intensity of the shock wave energy, the shock wave generating device for shaping the body cavity further comprises an insulating protective sleeve 7.
The insulating protective sleeve 7 is sleeved on the carrier 1 and covers the first inner electrode 2 and the second inner electrode 3. The insulating protective sleeve 7 is provided with an opening 8 to expose a part of the first inner electrode 2 and a part of the second inner electrode 3. In this embodiment, the opening 8 is an elongated slit. The insulating protective sleeve 7 is in a shape of a hexagon pipe, an octagon pipe and the like.
By providing an insulating protective sheath between the balloon and the carrier, covering part of the first and part of the second internal electrode, so that the current is communicated with the fluid only through the openings, the intensity of the shock wave can be increased. The shock wave generating device is applied to the blood vessels of the human body, so that the whole volume is small, the area of the first electrode and the area of the second electrode need to be controlled to ensure the intensity of the shock wave, the preparation difficulty of the electrodes can be further increased, part of the first inner electrode and part of the second inner electrode are covered by the insulating protective sleeve, the current only flows out through the slit, the volume of the inner electrode does not need to be strictly limited, only the area of the opening of the insulating protective sleeve needs to be changed, and the preparation difficulty of the whole shock wave generating device is reduced.
In the present embodiment, the first internal electrode 2 is a positive electrode, and the second internal electrode 3 is a negative electrode. The direction of the current is from the first inner electrode 2 to the second inner electrode 3. Because the first inner electrode 2 and the second inner electrode 3 are positioned at two opposite sides of the carrier 1, shock waves generated at two ends of the first inner electrode 2 and the second inner electrode 3 are emitted to different directions, and the method can be applied to the condition that the calcified tissues in blood vessels are in an asymmetric structure.
Further, as shown in fig. 2, the first internal electrode 2 and the second internal electrode 3 are both electrode sheets.
In order to better inhibit the generation of calcified tissue in the blood vessel, the surface of the balloon 4 may be coated with a medical solution for treating restenosis in the blood vessel. In addition, the surface of the balloon 4 may also be coated with paclitaxel, rapamycin, or other drugs that inhibit endothelialization.
Preferably, the balloon 4 is an open balloon, that is, the balloon 4 is provided with a plurality of micropores. Because of the small size of the micropores, the surface tension generated by the micropores can keep the instantaneous generation of high pressure in the balloon 4, thereby rapidly expanding the balloon 4. The open balloon is used for conveying the medicine to the blood vessel, so that the waste of the medicine can be avoided, and the cost is reduced.
In this embodiment, the balloon 4 includes an inner balloon and an outer balloon, and a plurality of micropores are formed on both the inner balloon 4 and the outer balloon 4. Further, the balloon 4 may also be in the form of a single leak or a double leak. The number of the balloons 4 may be two or more. When two balloons 4 are provided, one balloon 4 may contain a developing solution and physiological saline, and the other balloon 4 may be filled with a drug for treating intravascular restenosis.
Example 2
As shown in fig. 3, the present embodiment is different from embodiment 1 in that the number of the first internal electrodes 2 is plural. The plurality of first inner electrodes 2 are arranged side by side in the axial direction of the catheter. Each of the first internal electrodes 2 is a positive electrode. The second internal electrode 3 is a negative electrode. The second internal electrodes 3 are arranged on the outer surface of the carrier opposite to the respective first internal electrodes 2. And the second internal electrodes 3 are disposed at intermediate positions corresponding to the plurality of first internal electrodes 2. When the shock wave generating device acts on the blood vessel of a human body, under the action of an external power supply, each first inner electrode 2 is communicated with each second inner electrode 3 through liquid, and the liquid generates bubbles, so that shock wave energy is generated in the saccule 4.
Further, the plurality of first internal electrodes 2 are connected in series.
As another embodiment, the first internal electrodes 2 include a plurality of first positive internal electrodes and a plurality of first negative internal electrodes. The plurality of first positive internal electrodes and the plurality of first negative internal electrodes are arranged at intervals along the axial direction of the catheter. Two adjacent first positive internal electrodes and first negative internal electrodes form a group of electrodes. The second internal electrode is not energized at this time. And each group of electrodes are connected in parallel. Through the first inner electrode 2 arranged along the axial direction of the carrier, the shock wave generating device generates shock waves at one side in a blood vessel, and therefore the shock wave generating device is suitable for the situation that calcified tissues in the blood vessel are in an asymmetric structure.
Example 3
As shown in fig. 4, the present embodiment is different from embodiment 1 in that the first internal electrode 2 is a positive electrode; the number of the second internal electrodes 3 is plural. The plurality of second inner electrodes 3 are arranged side by side in the axial direction of the catheter. Each of the second internal electrodes 3 is a negative electrode. The first internal electrodes 2 are arranged on the outer surface of the carrier opposite to the respective second internal electrodes 3. And the first internal electrodes 2 are disposed at intermediate positions corresponding to the plurality of second internal electrodes 3. When the shock wave generating device acts on the blood vessel of a human body, under the action of an external power supply, the first inner electrode 2 is communicated with each second inner electrode 3 through liquid, and the liquid generates bubbles, so that shock wave energy is generated in the balloon 4.
Further, the plurality of second internal electrodes 3 are connected in series.
In another embodiment, the second internal electrodes 3 include a plurality of second positive internal electrodes and a plurality of second negative internal electrodes. The plurality of second positive internal electrodes and the plurality of second negative internal electrodes are arranged at intervals along the axial direction of the catheter. Two adjacent second positive internal electrodes and second negative internal electrodes form a group of electrodes. At this time, the first internal electrode is not energized. And each group of electrodes are connected in parallel. Through the second inner electrode 3 arranged along the axial direction of the carrier, the shock wave generating device generates shock waves at one side in a blood vessel, and further the shock wave generating device is suitable for the condition that calcified tissues in the blood vessel are in an asymmetric structure.
Example 4
As shown in fig. 5, this embodiment combines embodiment 2 and embodiment 3, and is different from embodiment 1 in that the number of the first internal electrodes 2 is plural, and the number of the second internal electrodes 3 is plural. Each of the first internal electrodes 2 is a positive electrode, and each of the second internal electrodes 3 is a negative electrode. One first internal electrode 2 is disposed to correspond to one second internal electrode 3. The opposing first 2 and second 3 internal electrodes are a set of electrodes.
Specifically, the plurality of first internal electrodes 2 are connected in series, and the plurality of second internal electrodes 3 are connected in series. As another embodiment, each set of electrodes is connected in parallel.
When the shock wave generating device acts on the blood vessel of a human body, under the action of an external power supply, each first inner electrode 2 is communicated with the corresponding second inner electrode 3 through liquid, and the liquid generates bubbles, so that shock wave energy is generated in the saccule.
Example 5
As shown in fig. 6, this embodiment is different from embodiment 5 in that each group of electrodes has an angular difference from the adjacent group of electrodes in the central axis direction of the carrier to realize spiral discharge. That is, in this embodiment, each set of electrodes is spirally disposed on the carrier, so that the shock wave generated by the shock wave generating device is in a spiral form.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The principles and embodiments of the present invention have been described herein using specific examples, which are provided only to help understand the method and the core concept of the present invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the invention.
Claims (9)
1. A shock wave generation device for shaping a body lumen, comprising: the device comprises a carrier, a first inner electrode, a second inner electrode, an insulating protective sleeve and a balloon;
the first internal electrode and the second internal electrode are respectively arranged on two opposite sides of the outer surface of the carrier; the first internal electrode is connected with an external power supply through a first lead, and the second internal electrode is connected with the external power supply through a second lead;
the saccule is wrapped on the carrier, a closed space is formed between the saccule and the carrier, the first inner electrode and the second inner electrode are positioned in the closed space, and liquid is filled in the closed space;
the insulating protective sleeve is sleeved on the carrier and covers the first inner electrode and the second inner electrode; an opening or a slit is arranged on the insulating protective sleeve to expose part of the first internal electrode and part of the second internal electrode.
2. The shock wave generating device for shaping a body lumen according to claim 1, wherein the carrier is a catheter.
3. The shock wave generating device for shaping the body lumen according to claim 1, wherein the first internal electrode is a positive electrode and the second internal electrode is a negative electrode; when the shock wave generating device acts on a blood vessel of a human body, the first inner electrode is communicated with the second inner electrode through liquid under the action of an external power supply, and the liquid generates bubbles, so that shock wave energy is generated in the balloon.
4. The shock wave generating device for shaping the body lumen according to claim 1, wherein the number of the first internal electrodes is plural, and each of the first internal electrodes is a positive electrode, and the second internal electrode is a negative electrode; when the shock wave generating device acts on the blood vessel of a human body, under the action of an external power supply, each first inner electrode is communicated with each second inner electrode through liquid, and the liquid generates bubbles, so that shock wave energy is generated in the saccule.
5. The shock wave generating device for shaping the body lumen according to claim 1, wherein the first internal electrode is a positive electrode, the number of the second internal electrodes is plural, and each of the second internal electrodes is a negative electrode; when the shock wave generating device acts on the blood vessel of a human body, the first inner electrode is communicated with the second inner electrodes through liquid under the action of an external power supply, and the liquid generates bubbles, so that shock wave energy is generated in the saccule.
6. The shock wave generating device for shaping the body lumen according to claim 1, wherein the first internal electrode is plural in number, and the second internal electrode is plural in number; each first internal electrode is a positive electrode, and each second internal electrode is a negative electrode; a first internal electrode and a second internal electrode are arranged correspondingly; the first and second internal electrodes are arranged in a group.
7. The shock wave generator according to claim 1, wherein each set of electrodes has an angular difference from the adjacent set of electrodes in the direction of the central axis of the carrier to achieve a spiral discharge.
8. The shock wave generator according to claim 7, wherein the liquid in the sealed space is a mixture of a developer and saline.
9. The shock wave generator for shaping the body lumen according to claim 1, wherein the balloon is provided with a plurality of micropores.
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| CN202210554513.1A CN114831697B (en) | 2022-05-19 | 2022-05-19 | Shock wave generating device for molding body cavity channel |
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| CN202210554513.1A CN114831697B (en) | 2022-05-19 | 2022-05-19 | Shock wave generating device for molding body cavity channel |
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