CN114797566A - Production equipment and method of influenza B vaccine - Google Patents
Production equipment and method of influenza B vaccine Download PDFInfo
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- CN114797566A CN114797566A CN202210454856.0A CN202210454856A CN114797566A CN 114797566 A CN114797566 A CN 114797566A CN 202210454856 A CN202210454856 A CN 202210454856A CN 114797566 A CN114797566 A CN 114797566A
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- vaccine
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- seedling
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C4/00—Crushing or disintegrating by roller mills
- B02C4/10—Crushing or disintegrating by roller mills with a roller co-operating with a stationary member
- B02C4/26—Crushing or disintegrating by roller mills with a roller co-operating with a stationary member in the form of a grid or grating
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C4/00—Crushing or disintegrating by roller mills
- B02C4/28—Details
- B02C4/42—Driving mechanisms; Roller speed control
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention belongs to the technical field of vaccine production, and is used for solving the problems that in the prior art, vaccine antigens need to be manually filtered and ground firstly and then are guided into a vaccine preparation barrel, so that the production efficiency of vaccines is reduced, and the internal temperature of the vaccines cannot be monitored in real time and automatic investigation cannot be performed in time; according to the invention, by arranging the grinding mechanism, the vaccine entering the vaccine preparation barrel can be continuously ground and filtered, so that the process of manually grinding the vaccine antigen is reduced, and time and labor are saved.
Description
Technical Field
The invention relates to the technical field of vaccine production, in particular to production equipment and a method of influenza B vaccine.
Background
With the continuous maturation of biotechnology, the vaccine field has been well developed, and vaccination is considered to be the most effective measure for preventing infectious diseases at present. Vaccine preparation is an important process in the production process of live vaccines, and is directly related to the quality of final vaccine products;
when preparing the seedling, require antigen and protective agent and other additive composition to mix completely evenly, therefore generally will unfreeze vaccine antigen filter in the funnel, introduce into and prepare the seedling bucket again, this kind of mode needs the manual work to filter the grinding to vaccine antigen earlier and then introduces into and prepares the seedling bucket, the work load of staff has not only been increased, simultaneously very hard, the production efficiency of vaccine has been reduced, and add the antigen after the glass bottle volume internal filtration to prepare the seedling bucket, there is the risk that leads to making the vaccine cause the loss and personnel are injured because the glass bottle is broken carelessly, current preparation of seedling bucket can't carry out real time monitoring feedback to the inside temperature of vaccine simultaneously, thereby can't carry out real time adjustment according to the vaccine condition, the security that the vaccine was stored has been reduced.
In view of the above technical drawbacks, a solution is proposed.
Disclosure of Invention
The invention aims to provide production equipment and a method of influenza B vaccines, wherein a grinding mechanism is arranged, so that vaccines entering a vaccine preparation barrel can be continuously ground and filtered, the process of manually grinding vaccine antigens is further reduced, time and labor are saved, meanwhile, the temperature of the vaccines entering different positions in the vaccine preparation barrel can be monitored in real time, texts are generated and displayed on the surface of a display screen, meanwhile, when the temperature of the vaccines is abnormal due to uneven cooling, the vaccines can be stirred, the mixing uniformity is ensured, and the problems that the production efficiency of the vaccines is reduced, the temperature inside the vaccines cannot be monitored in real time and cannot be automatically checked in time due to the fact that the vaccines need to be manually filtered and ground and then are led into the vaccine preparation barrel are solved.
In order to achieve the purpose, the invention provides the following technical scheme:
production equipment of influenza B vaccine comprises a vaccine preparation barrel, a vaccine preparation cover, a feed inlet, a discharge outlet, a solenoid valve, a support frame, a display screen, universal wheels and a control panel, wherein the universal wheels are arranged at four corners of the outer surface of the lower end of the support frame, the vaccine preparation barrel is detachably connected to the outer surface of the upper end of the support frame, the vaccine preparation cover is connected to the outer surface of the upper end of the vaccine preparation barrel through bolts, the feed inlet is arranged at the outer surface of the upper end of the vaccine preparation cover, the discharge outlet is arranged at the position, close to the bottom, of one side of the outer surface of the vaccine preparation barrel, the solenoid valve is arranged at the discharge outlet and the feed inlet, the display screen is arranged at the outer surface of one side of the vaccine preparation barrel, the control panel is arranged at the position, close to the bottom, of the inner part of the vaccine preparation barrel, the control panel is in electric signal connection with the display screen and the solenoid valve, the grinding mechanism is arranged at the outer surface of the upper end of the vaccine preparation cover, and the grinding mechanism penetrates into the inner part of the vaccine preparation cover, four groups of temperature sensors are arranged on two sides of the inner surface of the vaccine preparation barrel at equal distances, and divide the vaccine into four areas B 1 、B 2 、B 3 、B 4 Collecting temperature values of the vaccines in the four areas, wherein the temperature sensors are in electric signal connection with the control panel;
the grinding mechanism comprises a guide plate, a motor, a first rotating rod, a first rotating plate, a first magnet and a first magnet rod, wherein the position of the inner surface of the seedling matching cover below the feed inlet is detachably connected with the guide plate, a movable cavity is formed in the guide plate, the guide plate is hollow, the motor is arranged on the outer surface of the upper end of the seedling matching cover, an output shaft of the motor penetrates through the inner part of the seedling matching cover and is fixedly connected with the first rotating rod, the outer surface of the first rotating rod is positioned on the rotating block fixedly connected with the position above the guide plate, the outer surface of the rotating block is symmetrically and fixedly connected with the first two groups of first magnets, the first magnets are opposite in magnetic property, a plurality of groups of rolling rods are arranged in the movable cavity, the inner embedded type fixedly connected magnet rods of the rolling rods are arranged in the rolling rods, the magnetic properties of the magnet rods are the same, and the magnetic properties between the magnet rods are smaller than the magnetic properties between the first magnet rods, a stirring mechanism and a refrigerating assembly are arranged inside the seedling preparation barrel;
a data acquisition module, a data processing module, an operation monitoring module, a refrigeration unit and a controller are arranged in the control panel;
the data acquisition module is used for acquiring temperature values of different positions of the vaccine in the vaccine distribution barrel and transmitting the temperature values to the data processing module and the display screen;
after the data processing module receives temperature values of different positions of the vaccine, the data processing module carries out temperature safety value distinguishing operation on the vaccine to obtain a temperature abnormal signal and a temperature normal signal, and transmits the obtained signals to the operation monitoring module;
after the operation monitoring module receives the temperature abnormal signal, the alarm module is controlled to give an alarm, the temperature abnormal signal is transmitted to the refrigeration unit and the controller, the electromagnetic valves at the feed inlet and the discharge outlet are immediately closed after the controller receives the temperature abnormal signal, the stirring mechanism is started to stir the vaccine in the vaccine distribution barrel, the refrigeration unit adjusts the refrigeration temperature in the vaccine distribution barrel, and then data acquisition is performed again and the steps are repeated.
Further, rabbling mechanism includes electro-magnet, metal block, dwang two, bearing and puddler, the position that the bottom of joining in marriage seedling bucket internal surface is located the centre is provided with the bearing, and the dwang two pass through the bearing and join in marriage seedling bucket and rotate and be connected, the outer surface equidistance fixedly connected with a plurality of groups puddler of dwang two, and the outer fixed surface of upper end of dwang two is connected with the electro-magnet, the bottom of dwang one runs through to the lower extreme of deflector and detachable be connected with the metal block.
Furthermore, the outer surface of the lower end of the metal block is attached to the outer surface of the electromagnet, and the electromagnet is electrically connected with the control panel.
Furthermore, the guide plate is inclined towards the direction far away from the feed inlet by 30 degrees, and the inclination directions of the rotating block and the guide plate are consistent.
Further, cold-stored subassembly includes cooler and refrigeration pipe, the cooler sets up in the bottom of joining in marriage the seedling bucket, and the embedded inside of connecting in joining in marriage the seedling bucket of refrigeration pipe, and the cooler all is connected with refrigeration pipe and control panel.
Further, the specific manner of the vaccine temperature safety value discrimination operation is as follows:
the staff is constantly through the leading-in bacterin of feed inlet to the inside of joining in marriage seedling bucket, and bacterin gets into the inside of joining in marriage seedling bucket through the deflector, simultaneously with B 1 、B 2 、B 3 、B 4 The temperature values corresponding to the regions are respectively set as T 1 、T 2 、T 3 、T 4 And when the values are all within the preset range t, generating a normal temperature signal, otherwise, generating an abnormal temperature signal.
Further, the production method of the influenza B vaccine comprises the following steps:
firstly, a worker continuously introduces vaccines into the inner part of the vaccine preparation barrel through a feed port, the vaccines enter the inner part of the vaccine preparation barrel through a guide plate, at the moment, a motor operates and drives an output shaft and a rotating rod I of the motor to rotate, in the process of introducing the vaccines into the vaccine preparation barrel, two groups of magnets I with opposite magnetism are fixedly connected with the two sides of the rotating plate in a symmetrical mode, and magnet rods are fixedly connected with the inner parts of a plurality of groups of rolling rods in an embedded mode, the magnetism between the magnet rods is smaller than that between the magnet rods, so that the magnet I is driven by the rotating plate to rotate along with the rotating rod I, the magnet rods drive the rolling rods to roll in the movable cavity in a reciprocating mode, the vaccines are ground, the uniformity of mixing of the vaccines passing through the guide plate can be improved, and meanwhile the speed of the vaccines passing through filter holes of the guide plate is accelerated;
step two,At the same time, B 1 、B 2 、B 3 、B 4 The temperature values corresponding to the regions are respectively set as T 1 、T 2 、T 3 、T 4 When the values are all within the preset range t, generating a normal temperature signal, otherwise, generating an abnormal temperature signal;
step three, when receiving the abnormal temperature signal, the controller closes the electromagnetic valves of the feed inlet and the discharge outlet, the control panel confirms the cooling temperature of the cooler, and adjusts the cooling temperature to keep or restore to the normal value range, and simultaneously, the stirring mechanism is started, at the moment, the electromagnet has magnetism and is magnetically adsorbed with the metal block, so that the electromagnet drives the rotating rod II and the stirring rod on the surface of the rotating rod II to rotate along with the rotating rod I and stir the vaccine, the condition that the temperature of each part is excessively different due to uneven cooling of the vaccine is eliminated, the workload of manual inspection is reduced, data is collected again after 3min, the steps are repeated, if the frequency of receiving the abnormal temperature signal is more than or equal to three times, the worker manually inspects the vaccine and transmits the data to the display screen for display, and when the temperature is restored to normal, the electromagnet is not magnetic when the power is off, so that the stirring mechanism stops working;
and step four, when the normal temperature signal is received, the controller sends the data generation text to the display screen.
Compared with the prior art, the invention has the beneficial effects that:
according to the vaccine mixing device, the grinding mechanism is arranged, vaccines entering the inside of the vaccine mixing barrel can be continuously ground and filtered, the process of manually grinding vaccine antigens is further reduced, time and labor are saved, meanwhile, the temperature of the vaccines entering different positions of the inside of the vaccine mixing barrel can be monitored in real time, texts are generated and displayed on the surface of a display screen, and meanwhile, when the temperature of the vaccines is abnormal due to uneven cooling, the vaccines can be stirred, and the mixing uniformity of the vaccines is guaranteed.
Drawings
In order to facilitate understanding for those skilled in the art, the present invention will be further described with reference to the accompanying drawings;
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a combination view of the grinding mechanism and the stirring mechanism of the present invention;
FIG. 3 is a combined view of the guide plate and the rolling bar of the present invention;
FIG. 4 is an enlarged view of area A of FIG. 3 in accordance with the present invention;
fig. 5 is a block diagram of the system of the present invention.
Reference numerals: 1. preparing a seedling barrel; 2. preparing a seedling cover; 3. a feed inlet; 4. a discharge port; 5. an electromagnetic valve; 6. a support frame; 7. a display screen; 8. a universal wheel; 9. a control panel; 10. a grinding mechanism; 101. a guide plate; 102. a motor; 103. rotating the first rod; 104. a rotating plate; 105. a magnet I; 106. a magnet bar; 107. a movable cavity; 108. rotating the block; 109. a rolling bar; 11. a temperature sensor; 12. a stirring mechanism; 121. an electromagnet; 122. a metal block; 123. rotating the second rod; 124. a bearing; 125. a stirring rod; 13. a refrigeration assembly; 131. a cooler; 132. and (5) cooling the tube.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1 to 5, the present embodiment provides a technical solution:
production facility of influenza B vaccine, including joining in marriage seedling bucket 1, join in marriage seedling lid 2, feed inlet 3, discharge gate 4, solenoid valve 5, support frame 6, display screen 7, universal wheel 8 and control panel 9, four corners of the lower extreme surface of support frame 6 all are provided with universal wheel 8, and join in marriage the detachable upper end surface of connecting in support frame 6 of seedling bucket 1, the upper end surface of joining in marriage seedling bucket 1 has through bolted connection joins in marriage seedling lid 2, to the dismantlement of joining in marriage seedling lid 2 during in view of the clearance, the upper end surface of joining in marriage seedling lid 2 is provided with feed inlet 3, and join in marriage seedling bucket 1's upper end surfaceA discharge port 4 is arranged at one side of the outer surface close to the bottom end, electromagnetic valves 5 are arranged at the discharge port 4 and the feed port 3 to control the in and out of the vaccine, a display screen 7 is arranged on the outer surface of one side of the seedling matching barrel 1, a control panel 9 is arranged at the bottom end of the seedling matching barrel 1, the control panel 9 is connected with the display screen 7 and the electromagnetic valve 5 through electric signals, the outer surface of the upper end of the vaccine preparing cover 2 is provided with a grinding mechanism 10, the grinding mechanism 10 is utilized to grind and filter the vaccine entering the vaccine preparing barrel 1, and the grinding mechanism 10 penetrates into the seedling matching cover 2, four groups of temperature sensors 11 are arranged on two sides of the inner surface of the seedling matching barrel 1 at equal distances, the temperature sensors are used for measuring temperature values of different positions of vaccines in the collecting and distributing barrel 1, displaying the temperature values through the display screen 7, and dividing the vaccines into four areas B by the four groups of temperature sensors 11. 1 、B 2 、B 3 、B 4 The temperature values of the vaccines in the four areas are collected, and the temperature sensor 11 is in electric signal connection with the control panel 9;
the grinding mechanism 10 comprises a guide plate 101, a motor 102, a rotating rod 103, a rotating plate 104, a magnet 105 and a magnet rod 106, the guide plate 101 is detachably connected to the position, below the feed inlet 3, of the inner surface of the seedling matching cover 2, a movable cavity 107 is formed in the guide plate 101, the guide plate 101 is hollow, the motor 102 is arranged on the outer surface of the upper end of the seedling matching cover 2, an output shaft of the motor 102 penetrates into the seedling matching cover 2 and is fixedly connected with the rotating rod 103, the output shaft of the motor 102 drives the rotating rod 103 to rotate, the rotating block 108 is fixedly connected to the position, above the guide plate 101, of the outer surface of the rotating block 108, two groups of magnets 105 are symmetrically and fixedly connected to the outer surface of the rotating block 108, the magnetism of the two groups of magnets 105 is opposite, a plurality of rolling rods 109 are arranged in the movable cavity 107, and the magnet rod 106 is fixedly connected to the inner portion of the rolling rod 109 in an embedded manner, the magnetism of the magnet bars 106 is the same, in the process that the magnet bars 106 rotate along with the rotating block 108, the magnet bars 106 are repeatedly subjected to the action of magnetic adsorption force and magnetic repulsion force, the magnetism between the magnet bars 106 is smaller than that between the magnet bars 106 and the magnet bars 105, and the stirring mechanism 12 and the refrigerating assembly 13 are arranged inside the seedling blending barrel 1;
the vaccine is continuously introduced into the inner part of the vaccine preparing barrel 1 through the feed inlet 3 by the worker, the vaccine enters the inner part of the vaccine preparing barrel 1 through the guide plate 101, at the moment, the motor 102 operates and drives the output shaft and the rotating rod one 103 to rotate, in the process of introducing the vaccine into the vaccine distributing barrel 1, because two groups of magnets 105 with opposite magnetism are symmetrically and fixedly connected with the two sides of the rotating plate 104, and the magnet bars 106 are fixedly connected with the inner parts of the plurality of groups of rolling bars 109 in an embedded manner, the magnetism between the magnet bars 106 is smaller than that between the magnet bars 106 and the first magnet 105, therefore, when the rotating plate 104 drives the magnet one 105 to rotate along with the rotating rod one 103, the magnet rod 106 drives the rolling rod 109 to roll back and forth in the movable cavity 107, the vaccine is ground so as to accelerate the speed of the vaccine passing through the filtering holes of the guide plate 101 while improving the uniformity of the vaccine mixing through the guide plate 101.
A data acquisition module, a data processing module, an operation monitoring module, a refrigeration unit and a controller are arranged in the control panel 9;
the data acquisition module is used for acquiring temperature values of different positions of the vaccine in the vaccine distribution barrel 1 and transmitting the temperature values to the data processing module and the display screen 7;
after receiving the temperature values of different positions of the vaccine, the data processing module carries out temperature safety value distinguishing operation on the vaccine to obtain a temperature abnormal signal and a temperature normal signal and transmits the obtained signals to the operation monitoring module; the specific way of distinguishing the temperature safety value of the vaccine is as follows:
the staff is constantly through feed inlet 3 to the leading-in bacterin of the inside of joining in marriage seedling bucket 1, and bacterin gets into the inside of joining in marriage seedling bucket 1 through deflector 101, simultaneously with B 1 、B 2 、B 3 、B 4 The temperature values corresponding to the regions are respectively set as T 1 、T 2 、T 3 、T 4 When the values are all within the preset range t, generating a normal temperature signal, otherwise generating an abnormal temperature signal;
after the operation monitoring module receives the temperature abnormal signal, the operation monitoring module controls the alarm module to give an alarm and transmits the temperature abnormal signal to the cooling unit 7 and the controller, the controller immediately closes the electromagnetic valves 5 at the feed inlet 3 and the discharge outlet 4 after receiving the temperature abnormal signal and simultaneously starts the stirring mechanism 12, at the moment, the electromagnet 121 has magnetism and is magnetically adsorbed with the metal block 122, so that the electromagnet 121 drives the rotating rod two 123 and the stirring rod 125 on the surface of the rotating rod two to rotate along with the rotating rod one 103 and stir the vaccine, the condition that the temperature abnormal signal is generated due to the fact that the temperature of each part is excessively different because of uneven cooling of the vaccine is eliminated, the workload of manual investigation is reduced, data is collected again after 3min, the steps are repeated, and if the frequency of receiving the temperature abnormal signal is more than or equal to three times, a worker manually inspects the vaccine, and show data transmission to display screen 7, after the temperature recovered to be normal, electro-magnet 121 outage did not have magnetism, therefore rabbling mechanism 12 stop work, avoided rabbling mechanism 12 to stir the bacterin for a long time and lead to bacterin middle part to form the swirl to reduce the homogeneity that the bacterin mixes.
The working principle of the invention is as follows: the vaccine is continuously introduced into the vaccine preparing barrel 1 through the feed port 3 by the worker, the vaccine enters the vaccine preparing barrel 1 through the guide plate 101, at this time, the motor 102 operates and drives the output shaft and the rotating rod 103 to rotate, in the process of introducing the vaccine into the vaccine distributing barrel 1, because two groups of magnets 105 with opposite magnetism are symmetrically and fixedly connected with the two sides of the rotating plate 104, and the magnet bars 106 are fixedly connected with the inner parts of the plurality of groups of rolling bars 109 in an embedded manner, the magnetism between the magnet bars 106 is smaller than that between the magnet bars 106 and the first magnet 105, therefore, when the rotating plate 104 drives the magnet one 105 to rotate along with the rotating rod one 103, the magnet rod 106 drives the rolling rod 109 to roll back and forth in the movable cavity 107, grinding the vaccine so as to improve the uniformity of vaccine mixing passing through the guide plate 101 and accelerate the speed of the vaccine passing through the filter holes of the guide plate 101; at the same time, B 1 、B 2 、B 3 、B 4 The temperature values corresponding to the regions are respectively set as T 1 、T 2 、T 3 、T 4 When the values are all within the preset range t, generating a normal temperature signal, otherwise generating an abnormal temperature signal;
when a signal of abnormal temperature is received, the controller closes the electromagnetic valve 5 of the feed port 3 and the discharge port 4, the control panel 9 confirms the cooling temperature of the cooler 131, and adjusts the cooling temperature to keep or restore to a normal value range, and simultaneously, the stirring mechanism 12 is started, at the moment, the electromagnet 121 has magnetism and is magnetically adsorbed with the metal block 122, so that the electromagnet 121 drives the rotating rod two 123 and the stirring rod 125 on the surface of the rotating rod two to rotate along with the rotating rod one 103 and stir the vaccine, the condition that the temperature of each part is excessively different due to uneven cooling of the vaccine is eliminated, the workload of manual inspection is reduced, data is collected again after 3min, the steps are repeated, if the frequency of receiving the temperature abnormal signal is more than or equal to three times, a worker manually inspects the vaccine and transmits the data to the display screen 7 for display, when the temperature returns to normal, the electromagnet 121 is de-energized and becomes non-magnetic, so that the stirring mechanism 12 stops working.
The foregoing is merely exemplary and illustrative of the present invention and various modifications, additions and substitutions may be made by those skilled in the art to the specific embodiments described without departing from the scope of the invention as defined in the following claims.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise forms disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (7)
1. Production equipment of influenza B vaccine comprises a vaccine preparation barrel (1), a vaccine preparation cover (2), a feed inlet (3), a discharge port (4), a solenoid valve (5), a support frame (6), a display screen (7), universal wheels (8) and a control panel (9), and is characterized in that the universal wheels (8) are arranged at four corners of the outer surface of the lower end of the support frame (6), the vaccine preparation barrel (1) is detachably connected with the outer surface of the upper end of the support frame (6), the outer surface of the upper end of the vaccine preparation barrel (1) is connected with the vaccine preparation cover (2) through bolts, the feed inlet (3) is arranged on the outer surface of the upper end of the vaccine preparation cover (2), the discharge port (4) is arranged at a position close to the bottom end on one side of the outer surface of the vaccine preparation barrel (1), the solenoid valve (5) is arranged at the discharge port (4) and the feed inlet (3), and join in marriage one side surface of seedling bucket (1) and be provided with display screen (7), the position that the inside of joining in marriage seedling bucket (1) is located the bottom is provided with control panel (9), and control panel (9) and display screen (7) and the equal signal of telecommunication of solenoid valve (5) are connected, the upper end surface of joining in marriage seedling lid (2) is provided with grinds mechanism (10), and grinds mechanism (10) and run through to the inside of joining in marriage seedling lid (2), the impartial distance in both sides of the internal surface of joining in marriage seedling bucket (1) is provided with four temperature sensor groups (11), four groups temperature sensor (11) divide into four regional B with the bacterin into four 1 、B 2 、B 3 、B 4 The temperature values of the vaccines in the four areas are collected, and the temperature sensor (11) is in electric signal connection with the control panel (9);
the grinding mechanism (10) comprises a guide plate (101), a motor (102), a rotating rod (103), a rotating plate (104), a magnet (105) and a magnet rod (106), the inner surface of the seedling matching cover (2) is located below the feed inlet (3) and detachably connected with the guide plate (101), a movable cavity (107) is formed in the guide plate (101), the guide plate (101) is hollowed out, the motor (102) is arranged on the outer surface of the upper end of the seedling matching cover (2), an output shaft of the motor (102) penetrates through the inner part of the seedling matching cover (2) and is fixedly connected with the rotating rod (103), the outer surface of the rotating rod (103) is located above the guide plate (101) and is fixedly connected with a rotating block (108), the outer surface of the rotating block (108) is symmetrically and fixedly connected with two groups of magnets (105), and the magnetism of the magnets (105) is opposite, a plurality of groups of rolling rods (109) are arranged inside the movable cavity (107), magnet rods (106) are fixedly connected with the rolling rods (109) in an embedded mode, the magnetism of the magnet rods (106) is the same, the magnetism between the magnet rods (106) is smaller than that between the magnet rods (106) and the magnet I (105), and a stirring mechanism (12) and a refrigerating assembly (13) are arranged inside the seedling blending barrel (1);
a data acquisition module, a data processing module, an operation monitoring module, a refrigeration unit and a controller are arranged in the control panel (9);
the data acquisition module is used for acquiring temperature values of vaccines in different positions in the vaccine preparation barrel (1) and transmitting the temperature values to the data processing module and the display screen (7);
after receiving the temperature values of different positions of the vaccine, the data processing module carries out temperature safety value distinguishing operation on the vaccine to obtain a temperature abnormal signal and a temperature normal signal and transmits the obtained signals to the operation monitoring module;
after the operation monitoring module receives the temperature abnormal signal, the alarm module is controlled to give an alarm, the temperature abnormal signal is transmitted to the refrigerating unit and the controller, the electromagnetic valve (5) at the feed inlet (3) and the discharge outlet (4) is immediately closed after the controller receives the temperature abnormal signal, the stirring mechanism (12) is started to stir the vaccine in the seedling distribution barrel (1), the refrigerating unit adjusts the refrigerating temperature in the seedling distribution barrel (1), and then data acquisition is carried out again and the steps are repeated.
2. The production equipment of influenza B vaccine of claim 1, wherein the stirring mechanism (12) comprises an electromagnet (121), a metal block (122), a second rotating rod (123), a bearing (124) and a stirring rod (125), the bearing (124) is arranged at the middle position of the bottom of the inner surface of the seedling blending barrel (1), the second rotating rod (123) is rotatably connected with the seedling blending barrel (1) through the bearing (124), a plurality of groups of stirring rods (125) are fixedly connected to the outer surface of the second rotating rod (123) at equal intervals, the electromagnet (121) is fixedly connected to the outer surface of the upper end of the second rotating rod (123), and the bottom end of the first rotating rod (103) penetrates through to the lower end of the guide plate (101) and is detachably connected with the metal block (122).
3. The production equipment of the influenza B vaccine according to claim 2, wherein the outer surface of the lower end of the metal block (122) is attached to the outer surface of the electromagnet (121), and the electromagnet (121) is electrically connected with the control panel (9).
4. The apparatus and method for producing influenza B vaccine according to claim 1, wherein the guide plate (101) is inclined at 30 degrees to the direction away from the feed inlet (3), and the rotating block (108) is in the same direction as the inclined direction of the guide plate (101).
5. The production equipment of the influenza B vaccine according to claim 1, wherein the refrigeration component (13) comprises a cooler (131) and a refrigeration pipe (132), the cooler (131) is arranged at the bottom of the vaccine preparation barrel (1), the refrigeration pipe (132) is connected to the inside of the vaccine preparation barrel (1) in an embedded manner, and the cooler (131) is connected with the refrigeration pipe (132) and the control panel (9).
6. The apparatus for producing influenza b vaccine of claim 1, wherein the specific manner of the operation of discriminating the temperature safety value of the vaccine is as follows:
the staff continuously leads in the vaccine to the inside of the vaccine preparation barrel (1) through the feed inlet (3), the vaccine enters the inside of the vaccine preparation barrel (1) through the guide plate (101), and B is simultaneously introduced 1 、B 2 、B 3 、B 4 The temperature values corresponding to the regions are respectively set as T 1 、T 2 、T 3 、T 4 When the values are all within the preset range t, generating a normal temperature signal, otherwise generating a different temperature signalA constant signal.
7. The production method of the influenza B vaccine production facility according to claims 1 to 6, characterized in that the production method of the influenza B vaccine comprises the following steps:
firstly, a worker continuously introduces vaccines into the inner part of the vaccine preparation barrel (1) through the feed inlet (3), the vaccines enter the inner part of the vaccine preparation barrel (1) through the guide plate (101), at the moment, the motor (102) operates and drives the output shaft and the rotating rod I (103) to rotate, in the process of introducing the vaccines into the vaccine preparation barrel (1), because two groups of magnets I (105) with opposite magnetism are fixedly connected with the rotating plate (104) in a symmetrical mode at two sides, and magnet rods (106) are fixedly connected with the inner parts of a plurality of groups of rolling rods (109) in an embedded mode, the magnetism between the magnet rods (106) is smaller than that between the magnet rods (106) and the magnet I (105), the magnet rods (105) are driven to rotate along with the rotating rod I (103) by the rotating plate (104), the magnet rods (106) drive the rolling rods (109) to roll in the inner part of the movable cavity (107) in a reciprocating mode, and grind the vaccines, thereby improving the uniformity of vaccine mixing passing through the guide plate (101) and accelerating the speed of the vaccine passing through the filter holes of the guide plate (101);
step two, simultaneously adding B 1 、B 2 、B 3 、B 4 The temperature values corresponding to the regions are respectively set as T 1 、T 2 、T 3 、T 4 When the values are all within the preset range t, generating a normal temperature signal, otherwise generating an abnormal temperature signal;
step three, when a signal of abnormal temperature is received, the controller closes the electromagnetic valve (5) of the feed port (3) and the discharge port (4), the control panel (9) confirms the cooling temperature of the cooler (131), adjusts the cooling temperature to keep or recover the cooling temperature to a normal value range, and simultaneously starts the stirring mechanism (12), the electromagnet (121) has magnetism and is magnetically adsorbed with the metal block (122), so the electromagnet (121) drives the rotating rod two (123) and the stirring rod (125) on the surface of the rotating rod two to rotate along with the rotating rod one (101) and stir the vaccine, the condition that the temperature of each part is excessively different to generate an abnormal temperature signal due to uneven cooling of the vaccine is eliminated, the workload of manual inspection is reduced, data is collected again after 3min, the steps are repeated, if the frequency of receiving the abnormal temperature signal is more than or equal to three times, a worker carries out manual inspection on the vaccine, the data is transmitted to the display screen (7) for displaying, and when the temperature returns to normal, the electromagnet (121) is powered off and does not have magnetism, so the stirring mechanism (12) stops working;
and step four, when the temperature normal signal is received, the controller sends the data generation text to the display screen (7).
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