CN114797170A - Heparin sodium preparation facilities of high-efficient ion exchange - Google Patents
Heparin sodium preparation facilities of high-efficient ion exchange Download PDFInfo
- Publication number
- CN114797170A CN114797170A CN202210595879.3A CN202210595879A CN114797170A CN 114797170 A CN114797170 A CN 114797170A CN 202210595879 A CN202210595879 A CN 202210595879A CN 114797170 A CN114797170 A CN 114797170A
- Authority
- CN
- China
- Prior art keywords
- fixedly connected
- tray
- enclosing plate
- annular
- material tray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/02—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor with moving adsorbents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- External Artificial Organs (AREA)
Abstract
The invention relates to a heparin sodium preparation device with efficient ion exchange. The technical problems are as follows: the resin particles are in a static state during the adsorption process, and the resin particles at the bottom of the adsorption tank are tighter than those at the top, which influences the ion exchange rate of the resin particles at the bottom to the treatment liquid. The technical scheme is as follows: a heparin sodium preparation device with high-efficiency ion exchange comprises a tank cylinder, a second material tray and the like; the tank cylinder is connected with a second material tray in a sliding mode. The invention realizes the preparation of heparin sodium, realizes the turning of resin particles by controlling the first material tray and the second material tray to reciprocate up and down in the adsorption process, enables the treatment fluid to flow, improves the contact rate of the treatment fluid and the resin particles, further improves the ion exchange efficiency, and enables the eluent to intensively wash the resin particles at a short distance during elution, thereby improving the elution efficiency.
Description
Technical Field
The invention relates to the field of heparin sodium preparation, in particular to a heparin sodium preparation device with efficient ion exchange.
Background
In the Chinese patent with the application number of 201921532693.3, aiming at the problem of low treatment efficiency caused by the fact that the prior adsorption and elution are respectively carried out in an adsorption tank and an elution tank and resin transfer is needed, a heparin sodium filtering adsorption tank is disclosed, wherein a screen is arranged, the resin can be intercepted by the screen, filtrate generated during adsorption can be discharged from an outlet valve, and the resin can be remained in the tank body to finish adsorption, so that the pointed problem is solved; but the resin particles are in a static state in the adsorption process, the resin particles at the bottom of the adsorption tank are tighter than the resin particles at the top, which affects the ion exchange rate of the resin particles at the bottom to the treatment liquid, in addition, the treatment liquid at the lower part of the screen does not contact with the resin particles in the adsorption process, the ion exchange is incomplete, in addition, a large amount of eluent needs to be introduced during the elution process to elute the resin particles in the inner part in place, the time is long, and the material consumption is large.
Disclosure of Invention
In order to overcome the defect that the resin particles are in a static state in the adsorption process, the resin particles at the bottom of an adsorption tank are tighter than the resin particles at the top, which influences the ion exchange rate of the resin particles at the bottom to the treatment liquid, the invention provides a high-efficiency ion exchange heparin sodium preparation device.
The technical scheme is as follows: a heparin sodium preparation device for efficient ion exchange comprises bottom feet, a tank bottom, a connecting column, a tank barrel, a filling top, a first guide pipe, a second guide pipe and a screen plate; the tops of the four bottom feet are fixedly connected with a tank bottom; the middle part of the upper side of the tank bottom is fixedly connected with a connecting column; the outer edge of the upper side of the tank bottom is fixedly connected with a tank barrel; the top of the connecting column is fixedly connected with a top of the tank; the tank cylinder is fixedly connected with the irrigation top; the outer edge of the irrigation top is communicated with a first conduit; the outer edge of the tank bottom is communicated with a second conduit; the lower part of the outer surface of the connecting column is fixedly connected with a screen plate; the screen plate is connected with the tank cylinder in a sliding manner; the device also comprises a first material tray, a second material tray, a first leakage-proof unit, a second leakage-proof unit and a power unit; the outer surface of the connecting column is connected with a first material tray in a sliding manner; the tank cylinder is connected with a second material tray in a sliding way; the first material tray is connected with a first leakage-proof unit; the connecting column is connected with the first leakage-proof unit; the second tray is connected with a second leakage-proof unit; the tank bottom is connected with four power units, and the four power units are divided into two groups, one group is symmetrically arranged in front and back, and the other group is symmetrically arranged in left and right; the irrigation top is connected with the four power units; the first material tray is connected with the four power units; the second material tray is connected with the four power units; the power unit is connected with the screen plate; the power unit is used for driving the first material tray and the second material tray to reciprocate up and down, and the middle part and the outer part of the adsorbent are driven to move to turn the stack in the reciprocating movement process of the first material tray and the second material tray; the first leakage-proof unit and the second leakage-proof unit are used for preventing the first material disc and the second material disc from sliding off when driving the adsorbent to move.
Optionally, the first tray is conical and is provided with a through hole, the conical shape is beneficial to the downward sliding of the adsorbent, and the through hole is used for the solution to pass through.
Optionally, the section of the second tray is a right-angled triangle, and a through hole is formed in the second tray, the section of the second tray is the right-angled triangle, so that the adsorbent can slide down conveniently, and the through hole is used for allowing the solution to pass through.
Optionally, the first leakage-proof unit comprises a first mounting plate, a first wedge-shaped block, a first annular enclosing plate, a second annular enclosing plate, a first connecting ball, a second mounting plate, a second wedge-shaped block and a first elastic rope; the upper part of the outer surface of the connecting column is fixedly connected with two first mounting plates which are arranged in a left-right symmetrical mode; the lower sides of the two first mounting plates are fixedly connected with a first wedge-shaped block respectively; the outer edge of the upper side of the first material tray is fixedly connected with a first annular enclosing plate; the outer edge of the upper side of the first material tray is connected with a second annular enclosing plate in a sliding mode, and the second annular enclosing plate is located on the outer side of the first annular enclosing plate; the outer surface of the second annular enclosing plate is fixedly connected with two first connecting balls which are arranged in a bilateral symmetry manner; the middle part of the upper side of the first material tray is fixedly connected with four second mounting plates which are arranged in an annular array; the outer edges of the upper sides of the four second mounting plates are fixedly connected with a second wedge block respectively; the outer edge of the upper side of the first material tray is fixedly connected with a first elastic rope; the upper end of the first elastic rope is fixedly connected with the first annular enclosing plate.
Optionally, the first annular enclosing plate is provided with four rectangular openings, and the four rectangular openings are arranged in an annular array.
Optionally, the second annular enclosing plate is provided with four rectangular openings, and the four rectangular openings are arranged in an annular array.
Optionally, the second leakage-proof unit comprises a third annular enclosing plate, a fourth annular enclosing plate, a second connecting ball, a third mounting plate, a third wedge-shaped block and a second elastic rope; a third annular enclosing plate is fixedly connected to the upper side of the second material tray; the upper side of the second tray is connected with a fourth annular enclosing plate in a sliding manner, and the fourth annular enclosing plate is positioned on the inner side of the third annular enclosing plate; two second connecting balls are fixedly connected to the inner side of the fourth annular enclosing plate, and the two second connecting balls are arranged in a left-right symmetrical mode; the outer edge of the upper side of the second material tray is fixedly connected with four third mounting plates which are distributed in an annular array; the upper sides of the four third mounting plates are respectively and fixedly connected with a third wedge block; the upper side of the second tray is fixedly connected with a second elastic rope; the upper end of the second elastic rope is fixedly connected with the fourth annular enclosing plate.
Optionally, the third annular enclosing plate is provided with four rectangular openings, and the four rectangular openings are arranged in an annular array.
Optionally, the rear power unit comprises a first mounting frame, a second mounting frame, an electric rotating shaft, a wire guide wheel and a steel wire; the rear part of the upper side of the irrigation top is fixedly connected with a first mounting frame; the rear part of the lower side of the tank bottom is fixedly connected with a second mounting frame; the front part and the rear part of the first mounting frame are respectively and fixedly connected with an electric rotating shaft; the front part and the rear part of the second mounting frame are respectively fixedly connected with the electric rotating shaft; the rotating ends of the four electric rotating shafts are respectively and fixedly connected with a wire guide wheel; steel wires are wound on the four wire guide wheels; the steel wire is fixedly connected with the first material tray; the steel wire is fixedly connected with the second material tray; the steel wire is connected with the net plate in a sliding mode.
Optionally, an elution unit is also included; the irrigation top is connected with an elution unit; the first conduit is connected with the elution unit; the connecting column is connected with the elution unit; the elution unit comprises a fourth mounting plate, a first guide pipe, a connecting pipe, a second guide pipe and a linkage assembly; two fourth mounting plates are fixedly connected to the lower side of the irrigation top and are arranged in bilateral symmetry; the lower sides of the two fourth mounting plates are fixedly connected with a first flow guide pipe; the first guide pipe is communicated with the first guide pipe; the inner side of the first flow guide pipe is communicated with two connecting pipes which are symmetrically arranged in front and back; the two connecting pipes are communicated with a second flow guide pipe; the outer surface of the connecting column is connected with four linkage assemblies which are arranged in an annular array; the four linkage assemblies are connected with the second flow guide pipe; the four linkage assemblies are connected with the first guide pipe.
Compared with the prior art, the invention has the following advantages: the invention realizes the preparation of heparin sodium, realizes the turning of resin particles by controlling the first material tray and the second material tray to reciprocate up and down in the adsorption process, enables the treatment fluid to flow, improves the contact rate of the treatment fluid and the resin particles, further improves the ion exchange efficiency, and enables the eluent to intensively wash the resin particles at a short distance during elution, thereby improving the elution efficiency.
Drawings
FIG. 1 is a schematic diagram of a first three-dimensional structure of the high efficiency ion exchange heparin sodium preparation device of the present invention;
FIG. 2 is a perspective sectional view of the apparatus for preparing heparin sodium by high efficiency ion exchange of the present invention;
FIG. 3 is a schematic view of a first partial perspective structure of the apparatus for preparing heparin sodium by high efficiency ion exchange according to the present invention;
FIG. 4 is a schematic diagram of a second partial perspective structure of the apparatus for preparing heparin sodium by high efficiency ion exchange according to the present invention;
FIG. 5 is a schematic partial perspective view of a first leakage prevention unit of the high efficiency ion exchange heparin sodium preparation device according to the present invention;
FIG. 6 is a schematic view of a third partial perspective structure of the apparatus for preparing highly effective ion-exchanged heparin sodium according to the present invention;
FIG. 7 is a schematic perspective view of a second leakage-proof unit of the high-efficiency ion-exchange heparin sodium preparation device according to the present invention;
FIG. 8 is a schematic perspective view of the power unit of the apparatus for preparing heparin sodium by high efficiency ion exchange of the present invention;
FIG. 9 is a schematic view of a fourth partial perspective structure of the apparatus for preparing highly effective ion-exchanged heparin sodium according to the present invention;
FIG. 10 is a schematic perspective view of an elution unit of the apparatus for preparing heparin sodium by high efficiency ion exchange according to the present invention;
FIG. 11 is a partial perspective view of the elution unit of the high efficiency ion exchange heparin sodium preparation device according to the present invention;
fig. 12 is a schematic perspective view of the linkage assembly of the high efficiency ion exchange heparin sodium preparation device according to the present invention.
Reference numbers in the drawings: 1-footing, 2-pot bottom, 3-connecting column, 4-pot, 5-topping, 6-first conduit, 7-second conduit, 8-mesh plate, 201-first mounting plate, 202-first wedge, 203-first tray, 204-first annular bounding plate, 205-second annular bounding plate, 206-first connecting ball, 207-second mounting plate, 208-second wedge, 209-first elastic rope, 301-second tray, 302-third annular bounding plate, 303-fourth annular bounding plate, 304-second connecting ball, 305-third mounting plate, 306-third wedge, 307-second elastic rope, 401-first mounting frame, 402-second mounting frame, 403-electric rotating shaft, 404-guide wheel, 405-steel wire, 501-fourth mounting plate, 502-first guide pipe, 503-connecting pipe, 504-second guide pipe, 505-linkage component, 5051-elastic telescopic rod, 5052-fifth mounting plate, 5053-fourth wedge block, 5054-first baffle, 5055-sixth mounting plate, 5056-fifth wedge block and 5057-second baffle.
Detailed Description
Examples
A device for preparing heparin sodium by high-efficiency ion exchange is shown in figures 1-12 and comprises a bottom foot 1, a tank bottom 2, a connecting column 3, a tank cylinder 4, a filling top 5, a first conduit 6, a second conduit 7 and a mesh plate 8; the top parts of the four bottom feet 1 are welded with tank bottoms 2; the middle part of the upper side of the tank bottom 2 is welded with a connecting column 3; the outer edge of the upper side of the tank bottom 2 is welded with a tank barrel 4; the top of the connecting column 3 is welded with a top pouring 5; the tank 4 is welded with the irrigation top 5; the outer edge of the irrigation top 5 is communicated with a first conduit 6; the outer edge of the tank bottom 2 is communicated with a second conduit 7; the lower part of the outer surface of the connecting column 3 is fixedly connected with a screen plate 8; the screen plate 8 is in sliding connection with the tank barrel 4;
the device also comprises a first material tray 203, a second material tray 301, a first leakage-proof unit, a second leakage-proof unit and a power unit; the outer surface of the connecting column 3 is connected with a first material tray 203 in a sliding way; a second material tray 301 is connected in the tank barrel 4 in a sliding manner; the first tray 203 is connected with a first leakage-proof unit; the connecting column 3 is connected with the first leakage-proof unit; the second tray 301 is connected with a second leakage-proof unit; the tank bottom 2 is connected with four power units, and the four power units are divided into two groups, one group is symmetrically arranged in front and back, and the other group is symmetrically arranged in left and right; the irrigation roof 5 is connected with four power units; the first material tray 203 is connected with four power units; the second tray 301 is connected with four power units; the power unit is connected with the net plate 8.
The first tray 203 is conical and is provided with a through hole, the conical shape is beneficial to the downward sliding of the adsorbent, and the through hole is used for the solution to pass through.
The section of the second tray 301 is a right triangle and is provided with a through hole, the section of the second tray is a right triangle, the adsorbent can slide down conveniently, and the through hole is used for solution to pass through.
The first leakage-proof unit comprises a first mounting plate 201, a first wedge-shaped block 202, a first annular enclosing plate 204, a second annular enclosing plate 205, a first connecting ball 206, a second mounting plate 207, a second wedge-shaped block 208 and a first elastic rope 209; the upper part of the outer surface of the connecting column 3 is fixedly connected with two first mounting plates 201, and the two first mounting plates 201 are arranged in bilateral symmetry; a first wedge block 202 is welded on the lower sides of the two first mounting plates 201 respectively; a first annular enclosing plate 204 is welded on the outer edge of the upper side of the first tray 203; a second annular enclosing plate 205 is connected to the outer edge of the upper side of the first tray 203 in a sliding manner, and the second annular enclosing plate 205 is positioned on the outer side of the first annular enclosing plate 204; two first connecting balls 206 are fixedly connected to the outer surface of the second annular enclosing plate 205, and the two first connecting balls 206 are arranged in a left-right symmetrical mode; the middle part of the upper side of the first tray 203 is fixedly connected with four second mounting plates 207, and the four second mounting plates 207 are arranged in an annular array; the outer edges of the upper sides of the four second mounting plates 207 are fixedly connected with a second wedge-shaped block 208 respectively; a first elastic rope 209 is fixedly connected to the outer edge of the upper side of the first tray 203; the upper end of the first elastic rope 209 is fixedly connected with the first annular enclosing plate 204.
Four rectangular openings are formed in the first annular fence 204, and the four rectangular openings are arranged in an annular array.
Four rectangular openings are formed in the second annular enclosing plate 205, and the four rectangular openings are arranged in an annular array.
The second leakage-proof unit comprises a third annular enclosing plate 302, a fourth annular enclosing plate 303, a second connecting ball 304, a third mounting plate 305, a third wedge block 306 and a second elastic rope 307; a third annular enclosing plate 302 is fixedly connected to the upper side of the second tray 301; a fourth annular enclosing plate 303 is connected to the upper side of the second tray 301 in a sliding manner, and the fourth annular enclosing plate 303 is positioned on the inner side of the third annular enclosing plate 302; two second connecting balls 304 are fixedly connected to the inner side of the fourth annular bounding wall 303, and the two second connecting balls 304 are arranged in a left-right symmetrical mode; four third mounting plates 305 are welded on the outer edge of the upper side of the second tray 301, and the four third mounting plates 305 are distributed in an annular array; the upper sides of the four third mounting plates 305 are fixedly connected with a third wedge block 306 respectively; a second elastic rope 307 is fixedly connected to the upper side of the second tray 301; the upper end of the second elastic rope 307 is fixedly connected with the fourth annular enclosing plate 303.
Four rectangular openings are formed in the third annular shroud 302, and the four rectangular openings are arranged in an annular array.
Four rectangular openings are formed in the fourth annular enclosing plate 303, and the four rectangular openings are arranged in an annular array.
The power unit at the rear comprises a first mounting frame 401, a second mounting frame 402, an electric rotating shaft 403, a wire guide wheel 404 and a steel wire 405; the rear part of the upper side of the irrigation top 5 is fixedly connected with a first mounting frame 401; the rear part of the lower side of the tank bottom 2 is fixedly connected with a second mounting frame 402; the front part and the rear part of the first mounting frame 401 are fixedly connected with an electric rotating shaft 403 respectively; the front part and the rear part of the second mounting frame 402 are respectively fixedly connected with an electric rotating shaft 403; the rotating ends of the four electric rotating shafts 403 are respectively and fixedly connected with a wire guide wheel 404; steel wires 405 are wound on the four wire guide wheels 404; the steel wire 405 is fixedly connected with the first material tray 203; the steel wire 405 is fixedly connected with the second tray 301; steel cable 405 is slidably connected to net plate 8.
Also comprises an elution unit; the irrigation top 5 is connected with an elution unit; the first conduit 6 is connected with the elution unit; the connecting column 3 is connected with the elution unit; the elution unit comprises a fourth mounting plate 501, a first flow guide pipe 502, a connecting pipe 503, a second flow guide pipe 504 and a linkage assembly 505; two fourth mounting plates 501 are welded on the lower side of the irrigation roof 5, and the two fourth mounting plates 501 are arranged in a left-right symmetrical mode; the lower sides of the two fourth mounting plates 501 are fixedly connected with a first flow guide pipe 502; the first conduit 6 is in communication with the first draft tube 502; two connecting pipes 503 are communicated with the inner side of the first draft tube 502, and the two connecting pipes 503 are symmetrically arranged in front and back; the two connecting pipes 503 are communicated with a second flow guide pipe 504; the outer surface of the connecting column 3 is connected with four linkage assemblies 505, and the four linkage assemblies 505 are arranged in an annular array; four linkage assemblies 505 are connected with the second draft tube 504; four linkage assemblies 505 are coupled to the first delivery tube 502.
The first flow guide tube 502 is annular and has four holes, and the four holes are arranged in an annular array for controlling the solution to fall dispersedly.
The second flow guide pipe 504 is annular and has four holes, and the four holes are arranged in an annular array and used for controlling the solution to fall dispersedly.
The linkage assembly 505 includes an elastic telescoping rod 5051, a fifth mounting plate 5052, a fourth wedge 5053, a first baffle 5054, a sixth mounting plate 5055, a fifth wedge 5056, and a second baffle 5057; the outer surface of the connecting column 3 is fixedly connected with four elastic telescopic rods 5051, and the four elastic telescopic rods 5051 are arranged in an annular array; the telescopic ends of the four elastic telescopic rods 5051 are fixedly connected with a fifth mounting plate 5052 and a sixth mounting plate 5055 respectively, and the sixth mounting plate 5055 is located on the outer side of the fifth mounting plate 5052; a fourth wedge-shaped block 5053 is welded on the inner sides of the four fifth mounting plates 5052 respectively; a first baffle 5054 is welded on the upper sides of the four fourth wedge-shaped blocks 5053 respectively; the upper sides of the four first baffles 5054 are in contact with the second flow guide pipe 504; a fifth wedge-shaped block 5056 is welded on the outer sides of the four sixth mounting plates 5055 respectively; a second baffle 5057 is welded on the upper sides of the four fifth wedge-shaped blocks 5056 respectively; four second baffles 5057 are in contact with the first flow conduit 502.
When the heparin sodium pretreatment device works, a worker injects heparin sodium pretreatment liquid into a containing cavity formed by a tank bottom 2, a tank barrel 4 and a filling top 5 through a first conduit 6, ion exchange resin is placed in the containing cavity in advance and supported by a mesh plate 8, and then the environment in the containing cavity is adjusted to start ion exchange reaction; the resin particles at the bottom of the cavity are tighter than those at the top, which affects the ion exchange rate of the resin particles at the bottom to the treatment solution, so in the reaction process, four power units are controlled to start to drive the first material tray 203 and the second material tray 301 to move up and down in a reciprocating manner, when the first material tray 203 moves up, the second material tray 301 moves down, and when the first material tray 203 moves down, the second material tray 301 moves up; when the first tray 203 moves upwards, the first annular enclosing plate 204 and the second annular enclosing plate 205 are driven to move upwards, in the process, resin particles at the middle lower part of the cavity are driven to move upwards by a space formed by the first tray 203, the first annular enclosing plate 204 and the second annular enclosing plate 205, the middle lower part of the cavity is emptied out, meanwhile, the second tray 301 moves downwards to press the resin particles at the outer edge of the cavity downwards, and the particles at the outer edge of the cavity just fall to the middle lower part of the cavity which is just emptied out; the second annular enclosing plate 205 also drives the two first connecting balls 206 to move upwards, the two first connecting balls 206 move upwards to contact with the two first wedge-shaped blocks 202, and based on the top-down view, the two first wedge-shaped blocks 202 force the two first connecting balls 206 to rotate clockwise, the two first connecting balls 206 drive the second annular enclosing plate 205 to rotate clockwise to pull the first elastic rope 209, when the four rectangular openings of the second annular enclosing plate 205 coincide with the four rectangular openings of the first annular enclosing plate 204, the resin particles on the first tray 203 flow out of the rectangular openings and fall downwards, so that the resin particles on the lower part are positioned on the upper part, thus realizing the turning of the resin particles, improving the contact rate of the resin particles and the treatment liquid, further improving the ion exchange effect, and simultaneously enabling the treatment liquid to flow, and enabling the treatment liquid which is not contacted with the resin particles on the lower part of the screen plate 8 to flow upwards to contact with the resin particles, the ion exchange rate is improved; similarly, when the second tray 301 moves upwards, the third annular enclosing plate 302 and the fourth annular enclosing plate 303 are driven to move upwards, the cavity formed by the three parts drives the resin particles on the outer edge lower part to move upwards, meanwhile, the first tray 203 moves downwards to drive the resin particles in the middle part to move downwards to the space just left, when the fourth annular enclosing plate 303 moves upwards, the two second connecting balls 304 are driven to move upwards, the two second connecting balls 304 move upwards to be in contact with the two first wedge-shaped blocks 202, based on the top down view, the two first wedge-shaped blocks 202 force the two second connecting balls 304 to rotate clockwise, the two second connecting balls 304 drive the fourth annular enclosing plate 303 to rotate and stretch the second elastic rope 307, when the four rectangular ports of the fourth annular enclosing plate 303 rotate to coincide with the four rectangular ports of the third annular enclosing plate 302, the resin particles on the second tray 301 flow out from the rectangular openings and fall downwards, so that the resin particles originally positioned on the lower part are positioned on the upper part, thus realizing the turning of the resin particles; when the power unit at the rear works, the electric rotating shaft 403 is controlled to be started to drive the four wire guide wheels 404 to rotate, the four wire guide wheels 404 drive the steel wire 405 to rotate, the steel wire 405 drives the rear part of the second material tray 301 to move up and down, and the power unit at the front is matched to drive the second material tray 301 to integrally move up and down.
After ion particle exchange is completed, the treatment solution is led out through a second conduit 7, and then elution is performed on the resin particles; during elution, the elution liquid is poured into the first flow guide pipe 502 through the first flow guide pipe 6 and then is introduced into the second flow guide pipe 504 through the two connecting pipes 503, then the treatment liquid is dispersedly dropped into the containing cavity through the four holes on the first flow guide pipe 502 and the second flow guide pipe 504, the holes on the first flow guide pipe 502 and the second flow guide pipe 504 are half blocked by the first baffle 5054 and the second baffle 5057 in the initial state, when the first tray 203 carries the resin particles in the middle part upwards, the four second mounting plates 207 and the four second wedge-shaped blocks 208 are also driven to upwards move, the four second wedge-shaped blocks 208 upwards move to be in contact with the four fourth wedge-shaped blocks 5053, the four fourth wedge-shaped blocks 5053 are forced to outwards move, the four first baffle 5054 is driven by the four fourth wedge-shaped blocks 5053 to outwards move, so that the four first baffle 5054 is separated from the second flow guide pipe 504, the four wedge-shaped blocks 5053 simultaneously drive the telescopic end of the elastic telescopic rod 5051 to extend, the four elastic telescopic rods 5051 drive the four sixth mounting plates 5055, the four fifth wedge-shaped blocks 5056 and the four second baffles 5057 to move outwards, the four second baffles 5057 move to completely block the holes of the first flow guide pipe 502, so that eluent is sprayed on the resin particles on the first tray 203 from the second flow guide pipe 504 in a short distance, the resin particles are subjected to high-intensity elution, and the elution efficiency is enhanced; similarly, when the second tray 301 moves upwards, the four third mounting plates 305 and the four third wedge-shaped blocks 306 are also driven to move upwards, the four third wedge-shaped blocks 306 are in contact with the four fifth wedge-shaped blocks 5056, the four third wedge-shaped blocks 306 are forced to move inwards to be separated from the first flow guide pipe 502, the four third wedge-shaped blocks 306 are also driven by the four sixth mounting plates 5055 to move and compress the four elastic telescopic rods 5051, the four elastic telescopic rods 5051 drive the four fifth mounting plates 5052, the four fourth wedge-shaped blocks 5053 and the four first baffle plates 5054 to move, so that the four holes on the second flow guide pipe 504 are completely blocked, and thus eluent is in a short distance and is completely sprayed out from the first flow guide pipe 502 onto the resin particles on the second tray 301, the resin particles are subjected to high-intensity elution, and the elution efficiency is enhanced; the eluted eluent is led out through a second conduit 7.
The above-mentioned embodiments are merely preferred embodiments of the present invention, which are not intended to limit the scope of the present invention, and therefore, all equivalent changes made by the contents of the claims of the present invention should be included in the claims of the present invention.
Claims (10)
1. A heparin sodium preparation device for efficient ion exchange comprises a bottom foot (1), a tank bottom (2), a connecting column (3), a tank barrel (4), a filling top (5), a first guide pipe (6), a second guide pipe (7) and a screen plate (8); the tops of the four bottom feet (1) are fixedly connected with tank bottoms (2); the middle part of the upper side of the tank bottom (2) is fixedly connected with a connecting column (3); the outer edge of the upper side of the tank bottom (2) is fixedly connected with a tank barrel (4); the top of the connecting column (3) is fixedly connected with a top filling (5); the tank cylinder (4) is fixedly connected with the irrigation top (5); the outer edge of the irrigation top (5) is communicated with a first conduit (6); the outer edge of the tank bottom (2) is communicated with a second conduit (7); the lower part of the outer surface of the connecting column (3) is fixedly connected with a screen plate (8); the screen plate (8) is in sliding connection with the tank cylinder (4); the device is characterized by also comprising a first material tray (203), a second material tray (301), a first leakage-proof unit, a second leakage-proof unit and a power unit; the outer surface of the connecting column (3) is connected with a first material tray (203) in a sliding way; a second material tray (301) is connected in the tank barrel (4) in a sliding way; the first material tray (203) is connected with a first leakage-proof unit; the connecting column (3) is connected with the first leakage-proof unit; the second tray (301) is connected with a second leakage-proof unit; the tank bottom (2) is connected with four power units, and the four power units are divided into two groups, one group is symmetrically arranged in front and back, and the other group is symmetrically arranged in left and right; the irrigation top (5) is connected with four power units; the first material tray (203) is connected with four power units; the second tray (301) is connected with four power units; the power unit is connected with the screen plate (8); the power unit is used for driving the first material tray (203) and the second material tray (301) to reciprocate up and down, and the middle part and the outer part of the adsorbent are driven to move to turn during the reciprocating movement of the first material tray (203) and the second material tray (301); the first leakage-proof unit and the second leakage-proof unit are used for preventing the first tray (203) and the second tray (301) from sliding off when driving the adsorbent to move.
2. The device for preparing heparin sodium by high-efficiency ion exchange according to claim 1, wherein the first tray (203) is conical and is provided with through holes, the conical shape is beneficial for the adsorbent to slide downwards, and the through holes are used for the solution to pass through.
3. The device for preparing heparin sodium by high-efficiency ion exchange according to claim 1, wherein the section of the second tray (301) is a right triangle, and is provided with a through hole, the section of the right triangle is beneficial to the downward sliding of the adsorbent, and the through hole is used for the solution to pass through.
4. The device for preparing the high-efficiency ion-exchange heparin sodium according to claim 3, wherein the first leakage-proof unit comprises a first mounting plate (201), a first wedge-shaped block (202), a first annular enclosing plate (204), a second annular enclosing plate (205), a first connecting ball (206), a second mounting plate (207), a second wedge-shaped block (208) and a first elastic rope (209); the upper part of the outer surface of the connecting column (3) is fixedly connected with two first mounting plates (201), and the two first mounting plates (201) are arranged in a bilateral symmetry manner; the lower sides of the two first mounting plates (201) are respectively and fixedly connected with a first wedge-shaped block (202); the outer edge of the upper side of the first tray (203) is fixedly connected with a first annular enclosing plate (204); a second annular enclosing plate (205) is connected to the outer edge of the upper side of the first tray (203) in a sliding manner, and the second annular enclosing plate (205) is positioned on the outer side of the first annular enclosing plate (204); two first connecting balls (206) are fixedly connected to the outer surface of the second annular enclosing plate (205), and the two first connecting balls (206) are arranged in a left-right symmetrical mode; the middle part of the upper side of the first tray (203) is fixedly connected with four second mounting plates (207), and the four second mounting plates (207) are arranged in an annular array; the outer edges of the upper sides of the four second mounting plates (207) are fixedly connected with a second wedge-shaped block (208) respectively; the outer edge of the upper side of the first material tray (203) is fixedly connected with a first elastic rope (209); the upper end of the first elastic rope (209) is fixedly connected with the first annular enclosing plate (204).
5. The high efficiency ion exchange heparin sodium preparation device according to claim 4, wherein the first annular enclosing plate (204) is provided with four rectangular openings, and the four rectangular openings are arranged in an annular array.
6. The device for preparing heparin sodium by high-efficiency ion exchange according to claim 4, wherein the second annular enclosing plate (205) is provided with four rectangular openings, and the four rectangular openings are arranged in an annular array.
7. The device for preparing heparin sodium by high-efficiency ion exchange according to claim 6, wherein the second leakage-proof unit comprises a third annular enclosing plate (302), a fourth annular enclosing plate (303), a second connecting ball (304), a third mounting plate (305), a third wedge-shaped block (306) and a second elastic rope (307); a third annular enclosing plate (302) is fixedly connected to the upper side of the second tray (301); a fourth annular enclosing plate (303) is connected to the upper side of the second tray (301) in a sliding mode, and the fourth annular enclosing plate (303) is located on the inner side of the third annular enclosing plate (302); two second connecting balls (304) are fixedly connected to the inner side of the fourth annular enclosing plate (303), and the two second connecting balls (304) are arranged in a left-right symmetrical mode; the outer edge of the upper side of the second tray (301) is fixedly connected with four third mounting plates (305), and the four third mounting plates (305) are distributed in an annular array; the upper sides of the four third mounting plates (305) are fixedly connected with a third wedge block (306) respectively; a second elastic rope (307) is fixedly connected with the upper side of the second tray (301); the upper end of the second elastic rope (307) is fixedly connected with the fourth annular coaming (303).
8. The high efficiency ion exchange heparin sodium preparation device according to claim 7, wherein the third annular enclosing plate (302) is provided with four rectangular openings, and the four rectangular openings are arranged in an annular array.
9. The device for preparing heparin sodium by high-efficiency ion exchange according to claim 8, wherein the rear power unit comprises a first mounting frame (401), a second mounting frame (402), an electric rotating shaft (403), a wire guide wheel (404) and a steel wire (405); the rear part of the upper side of the irrigation top (5) is fixedly connected with a first mounting frame (401); the rear part of the lower side of the tank bottom (2) is fixedly connected with a second mounting frame (402); the front part and the rear part of the first mounting frame (401) are respectively and fixedly connected with an electric rotating shaft (403); the front part and the rear part of the second mounting frame (402) are respectively fixedly connected with the electric rotating shaft (403); the rotating ends of the four electric rotating shafts (403) are respectively and fixedly connected with a wire guide wheel (404); steel wires (405) are wound on the four wire guide wheels (404); the steel wire (405) is fixedly connected with the first material tray (203); the steel wire (405) is fixedly connected with the second material tray (301); the steel wire (405) is connected with the net plate (8) in a sliding way.
10. The device for preparing highly effective ion-exchanged heparin sodium according to claim 9, further comprising an elution unit; the irrigation top (5) is connected with an elution unit; the first conduit (6) is connected with the elution unit; the connecting column (3) is connected with the elution unit; the elution unit comprises a fourth mounting plate (501), a first flow guide pipe (502), a connecting pipe (503), a second flow guide pipe (504) and a linkage assembly (505); two fourth mounting plates (501) are fixedly connected to the lower side of the irrigation roof (5), and the two fourth mounting plates (501) are arranged in a left-right symmetrical mode; the lower sides of the two fourth mounting plates (501) are fixedly connected with a first flow guide pipe (502); the first conduit (6) is communicated with the first guide pipe (502); two connecting pipes (503) are communicated with the inner side of the first draft tube (502), and the two connecting pipes (503) are symmetrically arranged in front and back; the two connecting pipes (503) are communicated with a second draft tube (504); the outer surface of the connecting column (3) is connected with four linkage assemblies (505), and the four linkage assemblies (505) are arranged in an annular array; the four linkage assemblies (505) are connected with the second flow guide pipe (504); four linkage assemblies (505) are connected with the first draft tube (502).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210595879.3A CN114797170A (en) | 2022-05-30 | 2022-05-30 | Heparin sodium preparation facilities of high-efficient ion exchange |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210595879.3A CN114797170A (en) | 2022-05-30 | 2022-05-30 | Heparin sodium preparation facilities of high-efficient ion exchange |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114797170A true CN114797170A (en) | 2022-07-29 |
Family
ID=82518945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210595879.3A Withdrawn CN114797170A (en) | 2022-05-30 | 2022-05-30 | Heparin sodium preparation facilities of high-efficient ion exchange |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114797170A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117619456A (en) * | 2024-01-26 | 2024-03-01 | 祁县凯盛畜产品有限公司 | Resin elution device for preparing heparin sodium crude product and process method thereof |
-
2022
- 2022-05-30 CN CN202210595879.3A patent/CN114797170A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117619456A (en) * | 2024-01-26 | 2024-03-01 | 祁县凯盛畜产品有限公司 | Resin elution device for preparing heparin sodium crude product and process method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114797170A (en) | Heparin sodium preparation facilities of high-efficient ion exchange | |
| CN116688759B (en) | Ultrafiltration membrane with air pressure adjusting function | |
| CN202427670U (en) | Dynamic spray cleaning machine | |
| CN108246771A (en) | A kind of medical infusion bottle processing unit of environmental protection | |
| CN115138634B (en) | High-precision cleaning process for valve plate of speed changer | |
| CN209596649U (en) | A kind of Chemical Manufacture filter device | |
| CN114602212B (en) | Adsorption type extraction tower | |
| CN217220955U (en) | MBR membrane self-cleaning equipment | |
| CN111014022A (en) | Tea processing equipment | |
| CN215905841U (en) | Quantitative filling device is used in dairy products production | |
| CN115608581A (en) | Fire hose gluing process capable of eliminating bubbles | |
| CN210892815U (en) | Plate type heat exchanger | |
| CN208005438U (en) | A kind of end face automatic buffing equipment of short tube | |
| CN208912091U (en) | Ion exchange column | |
| CN208586185U (en) | New and effective sloping-plate sedimentation equipment | |
| CN209564820U (en) | A kind of Experiment of Organic Chemistry gas absorbing device | |
| CN214654739U (en) | A decoloration jar for tea-seed oil is concise | |
| CN216304347U (en) | Environment-friendly waste rubber powder modified asphalt concrete mixing equipment | |
| CN220780166U (en) | Flow guiding machine for processing injection | |
| CN213379981U (en) | Oil tank welding device | |
| CN216407070U (en) | Circulating water pump for bleaching powder production | |
| CN217687350U (en) | Wet-type water meter irrigation device | |
| CN219341846U (en) | Water treatment device based on water ecosystem | |
| CN220592609U (en) | Polishing mechanism for lens production | |
| CN117206225B (en) | Device and method for cleaning aquaculture netting |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20220729 |
|
| WW01 | Invention patent application withdrawn after publication |