CN114796718A

CN114796718A - Insulin refill and insulin pen of improvement

Info

Publication number: CN114796718A
Application number: CN202210590433.1A
Authority: CN
Inventors: 陈咨苗; 孙洪伟; 陈雄; 龚小花; 石大伟
Original assignee: First Affiliated Hospital of Wenzhou Medical University
Current assignee: First Affiliated Hospital of Wenzhou Medical University
Priority date: 2022-05-26
Filing date: 2022-05-26
Publication date: 2022-07-29

Abstract

The invention relates to an improved insulin refill and an insulin pen, wherein the refill comprises a refill shell, and the inside of the refill shell is of a hollow cylindrical structure; the top end of the refill shell is provided with a needle head connecting part, a rubber plug is arranged inside the needle head connecting part, and 3.75ml of common insulin can be reversely filled into the refill shell through the rubber plug and the needle head connecting part; the tail part in the refill shell is also provided with a refill plunger and a plunger retaining ring; the insulin pen comprises a pen core frame, a pen body, a dosage adjusting bolt and an injection button, wherein the pen core frame is used for accommodating the improved insulin pen core; the top end of the pen body is provided with a screw rod, and the dose adjusting bolt and the injection button are arranged at the tail end of the pen body; the screw rod can be driven to rotate and move along the axial direction of the pen body by pressing the injection button; the screw rod moves along the axial direction of the pen body to push the pen core plunger, so that the injection of the insulin is realized.

Description

Insulin refill and insulin pen of improvement

Technical Field

The invention relates to the technical field of medical instruments, in particular to an improved insulin refill and an insulin pen.

Background

In the prior art, the matched drug refill in the insulin pen is 3ml in specification, and the specification of a common refill is 100 u: 1ml, the maximum rotary scale of the insulin pen can be 60 grids when in use, and 1 grid is rotated every time, namely 1u of prepared insulin.

When the insulin pen in the prior art injects the medicine, the medicine can be injected by pressing an injection button after the dosage of the medicine is adjusted through a dosage adjusting bolt according to the treatment requirement only by filling the medicine refill and installing the injection needle. The refill is discarded after the liquid medicine in the filled medicine refill is used up, and a new medicine refill can be assembled again.

Problems with prior art insulin pens include:

1. the insulin refill in the prior art is special for biosynthesis of insulin or insulin analogues and is incompatible with common insulin;

2. the prior art insulin pen core (adult) has a minimum injection unit of 1u, which cannot be more finely adjusted for type 1 insulin or for insulin-sensitive people.

Disclosure of Invention

The invention aims to provide a novel improved insulin refill, and the technical problems to be solved comprise:

1. how to be compatible with common insulin, the price is low, and the use of low-income people is facilitated;

2. the minimum injection dosage can be controlled to be 0.5u, which is beneficial to more finely controlling the insulin dosage.

The invention aims to solve the defects of the prior art and provides a novel improved insulin refill, which comprises a refill shell, wherein the refill shell is internally provided with a hollow cylindrical structure; the top end of the refill shell is provided with a needle head connecting part, a rubber plug is arranged inside the needle head connecting part, and 3.75ml of common insulin can be reversely filled into the refill shell through the rubber plug and the needle head connecting part; the tail part in the refill shell is also provided with a refill plunger and a plunger retaining ring; the pen core plunger is movably arranged in the pen core shell, and the outer diameter of the pen core plunger is consistent with the inner diameter of the pen core shell; the plunger stop ring is of a fixedly arranged annular structure, the middle part of the plunger stop ring is of a hollow structure, so that a screw rod of the insulin pen can penetrate through the hollow structure to push the refill plunger to advance, the sectional area of the hollow structure is smaller than that of the refill plunger, and therefore the refill plunger stops moving when moving to the plunger stop ring, and the refill is reminded of being filled with insulin.

The filling amount of the modified insulin refill is 3.75 ml.

Preferably, the length of the modified insulin refill is equal to that of the original refill, the inner diameter of the modified insulin refill is increased to 1.18 times of the inner diameter of the original refill, and the volume of the modified insulin refill is increased to 1.25 times of the volume of the original refill.

Preferably, when 3.75ml of common insulin is reversely injected into the modified insulin pen core through the preposed rubber plug, the dose of the insulin in the modified insulin pen core is 150 u; when the improved insulin pen core is assembled to an insulin pen, the unit of injected insulin is 0.5u per 1 rotation of the insulin pen.

The invention also provides an insulin pen, which comprises a pen core frame, a pen body, a dose adjusting bolt and an injection button, wherein the pen core frame is used for accommodating the improved insulin pen core; the top end of the pen body is provided with a screw rod, and the dose adjusting bolt and the injection button are arranged at the tail end of the pen body; the tail end of the refill holder can be connected with the top end of the pen body, and the top of the screw rod is abutted against the end part of the improved insulin refill in the refill holder; the screw rod can be driven to rotate and move along the axial direction of the pen body by pressing the injection button; the refill plunger in the improved insulin refill is pushed by the axial movement of the screw rod along the pen body, so that the injection of insulin is realized.

The top of refill frame be provided with syringe needle bearing part that syringe needle connecting portion match, the tail end of refill frame is provided with the opening, the insulin refill of improvement insert through this opening the inside of refill frame.

Preferably, a hollow window is arranged on the side wall of the refill holder for observing the improved insulin refill and the screw rod.

A dosage window is arranged on the side wall of the pen body, and dosage indicating marks are arranged inside the dosage window.

The side wall of the pen body is also provided with a label.

Further preferably, the insulin pen further comprises a pen cap for buckling outside the pen core holder and wrapping the whole pen core holder.

Advantageous effects

Compared with the prior art, the invention has the beneficial effects that:

the improved insulin refill disclosed by the invention can inject and fill common insulin into the empty improved refill device, namely the common insulin can be injected by using the insulin injection pen in the prior art, and in the injection process, the injection of the common insulin is equivalent to the adjustment of 0.5u for injecting the common insulin by adjusting 1 scale unit every time, so that the technical bottleneck that the common insulin cannot be used by using the existing device is broken; on the other hand, the common insulin is short-acting insulin, the biological effect of the common insulin is not much different from that of artificially synthesized insulin, but the price of the common insulin is much cheaper than that of the biologically synthesized insulin, the common insulin is used as a refill medium, the common insulin is beneficial to wide use of the vast population with low income, and furthermore, due to the use of the novel insulin refill device, the minimum unit of injected insulin is 0.5u, which is very beneficial to the blood sugar control of fragile diabetes, namely type 1 diabetes which is particularly sensitive to insulin or special diabetes, and avoids the accidental injury of iatrogenic hypoglycemia to patients.

Drawings

The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention.

FIG. 1 is a front view of the improved insulin pen core of the present invention.

Fig. 2 is a schematic bottom cross-sectional view of the modified insulin cartridge of the present invention.

Fig. 3 is a schematic structural diagram of the insulin pen of the present invention.

Fig. 4 is a schematic structural diagram of a pen cap of the insulin pen.

Fig. 5 is a schematic structural diagram of the insulin pen of the present invention before the refill is filled.

Fig. 6 is a schematic structural diagram of the insulin pen of the present invention after the refill is filled.

Detailed Description

The present invention is described in more detail below to facilitate an understanding of the present invention.

As shown in fig. 1 to 6, the improved insulin pen core of the present invention comprises a pen core housing 1, the interior of which is a hollow cylinder structure; the top end of the refill shell is provided with a needle head connecting part 2, a rubber plug 3 is arranged inside the needle head connecting part, and 3.75ml of common insulin (40 u: 1ml) can be reversely filled into the refill shell through the rubber plug and the needle head connecting part; the tail part in the refill shell is also provided with a refill plunger 4 and a plunger retaining ring 5. The pen core plunger 4 is movably arranged in the pen core shell, and the outer diameter of the pen core plunger is consistent with the inner diameter of the pen core shell; the plunger stop ring 5 is of a fixedly arranged annular structure, the middle part of the plunger stop ring 5 is of a hollow structure, so that a screw rod of the insulin pen can penetrate through the hollow structure to push the refill plunger to advance, the sectional area of the hollow structure is smaller than that of the refill plunger, and therefore the refill plunger stops moving when moving to the plunger stop ring, and the refill is reminded of being filled with insulin.

The filling amount of the modified insulin refill is 3.75 ml.

Preferably, the length H of the modified insulin refill is unchanged compared to the prior art primary refill, the inner diameter R is increased to 1.118 times the inner diameter of the primary refill, and the volume is increased to 1.25 times the volume of the primary refill.

When 3.75ml of common insulin is reversely injected into the improved insulin refill through the preposed rubber plug, the dose of the insulin in the improved insulin refill is 150 u; the improved insulin pen core is assembled to an insulin pen, and 0.5u of insulin is obtained after 1 rotation.

In order to prevent the amount of the modified insulin refill from exceeding 3.75ml in the process of filling the modified empty insulin refill with common insulin, the modified insulin refill can be provided with an inner glass ring (with the diameter of 0.2mm) block at 3.75ml, and can also be marked with scales as a capacity prompt.

The invention also provides an insulin pen, which comprises a refill holder 6, a pen body 8, a dose adjusting bolt 9 and an injection button 11, wherein the refill holder 6 is used for accommodating the improved insulin refill; the top end of the pen body 8 is provided with a screw rod 12, and the dose adjusting bolt 9 and the injection button 11 are arranged at the tail end of the pen body 8; the tail end of the refill holder 6 can be connected with the top end of the pen body 8, and the top of the screw rod 12 is abutted with the end of the improved insulin refill in the refill holder; by pressing the injection button 11, the screw rod 12 can be driven to rotate and move along the axial direction of the pen body; the refill plunger 4 in the improved insulin refill is pushed by the axial movement of the screw rod along the pen body, so that the injection of the insulin is realized.

The top of the refill holder 6 is provided with a needle bearing part 61 matched with the needle connecting part 2, the tail end of the refill holder 6 is provided with an opening part 62, and the improved insulin refill is inserted into the refill holder 6 through the opening part.

Preferably, a hollow window 7 is provided on the side wall of the cartridge holder 6 for viewing the modified insulin cartridge and the screw rod 12.

A dosage window 13 is arranged on the side wall of the pen body 8, and dosage indicating marks 14 are arranged inside the dosage window.

The side wall of the pen body 8 is also provided with a label 15.

Further preferably, the insulin pen further comprises a cap 16 for covering the outside of the cartridge holder 6 and enclosing the entire cartridge holder.

Because the original matched pen core is 3ml in specification, the specification of the common pen core is 100 u: 1ml, the maximum rotary scale of the insulin pen can be 60 grids when in use, and 1 grid is rotated every time, namely 1u of prepared insulin. If the ordinary insulin (400: 10ml, namely 40 u: 1ml) is directly put into the primary refill, the dosage of the ordinary insulin actually filled at the moment is 120u, and at the moment, the dosage of the ordinary insulin is 0.4u per rotation, provided that the filling amount is unchanged every time, namely, each refill is still in a 3ml specification.

In order to achieve that 0.5u can be injected per rotation (clinically, the doctor adjusts the insulin dosage by integer, the minimum unit is 0.5u is more beneficial to fine adjustment and is very beneficial to patients with unstable blood sugar, and the 0.4u adjustment is not beneficial to application conversion between common insulin and biosynthetic insulin or insulin analogues and is disjointed with the medication habit of the clinician), the application generates the volume of 0.5/0.4 times of the original volume when the piston (namely the refill plunger 4) is moved. If the length of the refill is not changed, the cross-sectional area of the inner diameter of the refill needs to be increased to 1.25 times, namely, the inner diameter is increased to 1.118 times of the inner diameter of the primary refill.

The volume of the refill is increased to 3.75ml, and common insulin (40 u: 1ml) is reversely injected into the refill through the preposed rubber plug, wherein the dose of the insulin in the refill is 150 u; the improved customized medicine refill is assembled to the insulin pen, and 0.5u of insulin is obtained after 1 rotation.

In the prior art, the biosynthetic insulin or insulin analogue is only used for a special matched injection pen, the common insulin does not have a corresponding refill device and a corresponding injection pen, the common insulin is low in price and expensive in price, the matched injection pen has large price difference, the improved refill can be filled with the common insulin, so that the common insulin can be applied to the existing injection pen through the improved refill like the synthetic insulin or insulin analogue, and the conversion of the dosage is very accurate and reasonable.

The foregoing describes preferred embodiments of the present invention, but is not intended to limit the invention thereto. Those skilled in the art may make modifications and variations to the embodiments disclosed herein without departing from the scope and spirit of the invention.

Claims

1. An improved insulin pen core is characterized by comprising a pen core shell, wherein the interior of the pen core shell is of a hollow cylinder structure; the top end of the refill shell is provided with a needle head connecting part, a rubber plug is arranged inside the needle head connecting part, and 3.75ml of common insulin can be reversely filled into the refill shell through the rubber plug and the needle head connecting part; the tail part in the refill shell is also provided with a refill plunger and a plunger retaining ring; the pen core plunger is movably arranged in the pen core shell, and the outer diameter of the pen core plunger is consistent with the inner diameter of the pen core shell; the plunger stop ring is of a fixedly arranged annular structure, the middle part of the plunger stop ring is of a hollow structure, so that a screw rod of the insulin pen can penetrate through the hollow structure to push the refill plunger to advance, the sectional area of the hollow structure is smaller than that of the refill plunger, and therefore the refill plunger stops moving when moving to the plunger stop ring, and the refill is reminded of being filled with insulin.

2. The modified insulin pen core as claimed in claim 1, wherein the filling amount of said modified insulin pen core is 3.75 ml.

3. The modified insulin pen core as claimed in claim 1, wherein the length of said modified insulin pen core is equal to the length of the original refill, the inner diameter of said modified insulin pen core is increased to 1.18 times the inner diameter of the original refill, and the volume of said modified insulin pen core is increased to 1.25 times the volume of the original refill.

4. The modified insulin pen core as claimed in claim 1, wherein when the modified insulin pen core is filled with 3.75ml of normal insulin reversely through the preposed rubber plug, the insulin dosage in the modified insulin pen core is 150 u; when the improved insulin refill is assembled to an insulin pen, the unit of injected insulin is 0.5u per 1-rotation of the insulin pen.

5. An insulin pen, comprising a cartridge holder for accommodating the modified insulin cartridge of any one of claims 1 to 4, a pen body, a dose adjustment peg, and an injection button; the top end of the pen body is provided with a screw rod, and the dose adjusting bolt and the injection button are arranged at the tail end of the pen body; the tail end of the refill holder can be connected with the top end of the pen body, and the top of the screw rod is abutted against the end part of the improved insulin refill in the refill holder; the screw rod can be driven to rotate and move along the axial direction of the pen body by pressing the injection button; the refill plunger in the improved insulin refill is pushed by the axial movement of the screw rod along the pen body, so that the injection of insulin is realized.

6. The insulin pen according to claim 5, wherein the top end of the pen core holder is provided with a needle bearing part matching with the needle connecting part, and the tail end of the pen core holder is provided with an opening part through which the modified insulin pen core is inserted into the interior of the pen core holder.

7. The insulin pen according to claim 5, wherein a hollow window is provided on the side wall of the cartridge holder for viewing the modified insulin cartridge and the screw rod.

8. The insulin pen of claim 5, wherein a dosage window is disposed on a side wall of the pen body, and dosage indicating indicia is disposed inside the dosage window.

9. The insulin pen of claim 5, wherein a label is further disposed on the side wall of the pen body.

10. The insulin pen according to claim 5, characterized in that, the insulin pen further comprises a cap for covering the outside of the cartridge holder and enclosing the entire cartridge holder.