CN114770912A - Micro-flow pipeline stretching system and stretching method - Google Patents
Micro-flow pipeline stretching system and stretching method Download PDFInfo
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- CN114770912A CN114770912A CN202210208865.1A CN202210208865A CN114770912A CN 114770912 A CN114770912 A CN 114770912A CN 202210208865 A CN202210208865 A CN 202210208865A CN 114770912 A CN114770912 A CN 114770912A
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C55/00—Shaping by stretching, e.g. drawing through a die; Apparatus therefor
- B29C55/22—Shaping by stretching, e.g. drawing through a die; Apparatus therefor of tubes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
- B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2023/00—Tubular articles
- B29L2023/005—Hoses, i.e. flexible
Abstract
The invention discloses a micro-flow pipeline stretching system and a stretching method, wherein the system comprises a substrate, a roller shaft supporting shell and a passive rotating shaft; the roller shaft supporting shell is fixed on the surface of the substrate; the driven rotating shaft is fixed in a roller of the roller shaft supporting shell; one end of the driven rotating shaft is provided with a rolling roller and a torque roller, and the torque roller is attached to the rolling roller; the other end of the driven rotating shaft is provided with a coupler, and the coupler is connected to a stepping motor; the scheme can stretch the micro-flow pipeline under the condition of heating the micro-flow pipeline, and the process accuracy and reliability of the micro-flow pipeline are improved through controlling the rotating speed of the motor, so that the micro-flow pipeline can be widely applied to the technical field of pipeline processing.
Description
Technical Field
The invention relates to the technical field of pipeline processing, in particular to a micro-flow pipeline stretching system and a stretching method.
Background
Microfluidics refers to the technology and science involved in systems that operate or process microfluidics using microchannels, an emerging interdisciplinary discipline involving multiple disciplines. The main manufacturing materials of the micro-fluidic chip generally need higher hydrophobicity in order to reduce flow resistance, and can prevent blockage and ensure smooth flow of fluid in a pipeline, common materials include Polydimethylsiloxane (PDMS), silicon wafers, glass, polytetrafluoroethylene, polymethyl methacrylate, paper base and the like, wherein the application range of PDMS is the widest, and the density of PDMS micro valves can reach 30 per centimeter. And the PDMS material has the characteristic of easy adsorption of hydrophobic micromolecules, so that detection deviation and background rise are caused. Meanwhile, the paper base has the characteristics of large specific surface area, low price and hydrophilic capillary force, and the method of longitudinal stacking and hydrophobic patterning is adopted, so that the advantages of multi-step operation integration and multi-element detection are specifically reflected, and the method is suitable for portable microfluidic chips.
Different micromachining methods depend on different material properties, but the two most prominent fabrication methods for microfluidic chips are soft lithography for surface patterning and lithography in the microelectronics industry. The inner diameter of the existing commercial polymer (PTFE \ PVC \ FEP) pipeline commonly used for the microfluidic pipeline is larger (minimum 0.3mm), and in order to prevent droplets in the pipeline from colliding and fusing with each other, the size of the droplets needs to be slightly larger than that of the pipeline, so that the minimum size of the droplets in the existing pipeline is about 8 nanoliters, and the high-flux technical index of 1 nanoliter droplets in the conventional PCR detection cannot be met; therefore, the precision and reliability of the prior art microfluidic pipeline fabrication process are relatively low.
Disclosure of Invention
Accordingly, to at least partially solve one of the above technical problems, embodiments of the present invention provide a stretching system and a stretching method for a microfluidic pipeline with higher accuracy and reliability.
The technical scheme adopted by the invention is as follows:
in a first aspect, the invention provides a microfluidic pipeline stretching system, which comprises a substrate, a roller shaft supporting shell and a driven rotating shaft; the roller shaft supporting shell is fixed on the surface of the substrate; the driven rotating shaft is fixed in a roller of the roller shaft supporting shell; one end of the driven rotating shaft is provided with a rolling roller and a torque roller, and the torque roller is tightly attached to the rolling roller; and the other end of the driven rotating shaft is provided with a coupler, and the coupler is connected to the stepping motor.
In some optional embodiments, a first surface of the winding roller is provided with a first heating film, the first heating film is used for heating the micro-flow pipeline wound on the winding roller, and the first surface is a surface with a rectangular projection.
In some optional embodiments, the stretching system further includes a second heating film covering a surface of the microfluidic pipeline wound around the winding roller, the second heating film is configured to form a heating film interlayer with the first heating film, and the heating film interlayer is configured to heat the microfluidic pipeline.
In some optional embodiments, the stretching system further comprises a PID controller and a heating component, the PID controller is connected to the heating component, and the heating component is connected to the first heating film and/or the second heating film.
In some optional embodiments, a main rotating shaft is disposed at one end of the coupler away from the passive rotating shaft, and the main rotating shaft is used for fixing with the stepping motor and driving the passive rotating shaft through coaxial transmission.
In some optional embodiments, the stretching system further comprises a temperature sensor disposed on the first surface; the temperature sensor is used for acquiring the temperature of the first heating film.
In a second aspect, the present invention provides a microfluidic pipeline stretching method, including the following steps:
the micro-flow pipeline is heated through the first heating film covered on the surface of the rolling roller,
the motor drives the rolling roller, and the micro-flow pipeline after rolling and heating is rotated by the rolling roller so as to stretch and heat the micro-flow pipeline.
In some optional embodiments, the stretching method may further comprise the steps of:
covering a second heating film on the micro-flow pipeline wire coil wound by the winding roller;
and heating the microfluidic pipeline through a heating film interlayer formed by the first heating film and the second heating film.
In some optional embodiments, the stretching method may further comprise the steps of:
and determining that the rotating speed of the winding roller is greater than the rotating speed of the motor, or determining that the rotating speed of the winding roller is greater than a preset rotating speed threshold value, and controlling the passive rotating shaft to be separated from the coupler.
In some optional embodiments, the stretching method may further comprise the steps of:
the torque roller drives the rolling roller, and the micro-flow pipeline is rolled and heated by the rolling roller to be stretched and heated.
Advantages and benefits of the present invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention:
the technical scheme of the application provides a micro-flow pipeline stretching system which comprises a substrate, a roller shaft supporting shell and a driven rotating shaft; the passive rotation axis front end is the moment of torsion gyro wheel and tightens up the gyro wheel, can tighten up the miniflow pipeline through tightening up the gyro wheel winding, and the shaft coupling is connected to passive rotation axis rear end, through coupling joint step motor, and the system can be under the condition that heats the miniflow pipeline, stretches the miniflow pipeline, through the control to motor speed to it is higher to improve miniflow pipeline process accuracy degree and reliability.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a front view of a microfluidic tubing stretching system of the present invention;
FIG. 2 is a top view of a microfluidic channel stretching system according to the present invention;
FIG. 3 is a schematic view of a micro-flow tube being rolled by a micro-flow tube stretching system according to the present invention;
FIG. 4 is a flow chart illustrating steps of a microfluidic channel stretching method according to the present invention;
FIG. 5 is a flow chart illustrating steps of another microfluidic channel stretching method according to the present invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention and are not to be construed as limiting the present invention.
In the description of the present invention, it is to be understood that the terms "length," "upper," "lower," "front," "rear," "left," "right," "top," "inner," "outer," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the present invention and for simplicity in description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be construed as limiting the present invention. Furthermore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in a specific case to those of ordinary skill in the art.
The technical scheme is that the micro-flow pipeline stretching system and the stretching method are used for solving the problems that in the prior art, the accuracy and the reliability in the manufacturing process of the micro-flow pipeline are relatively low and the like. In a first aspect, as shown in fig. 1 and fig. 2, the invention provides a stretching system for a microfluidic pipeline, which mainly comprises a substrate 101, a roller bearing housing 102 and a passive rotating shaft 103;
fig. 1 is a front view of a stretching system of a microfluidic pipeline in this embodiment, and fig. 2 is a top view of the stretching system of the microfluidic pipeline in this embodiment; the roller shaft support housing 102 is fixed to the surface of the base 101; the passive rotating shaft 103 is fixed in the roller of the roller shaft support shell 102; one end of the driven rotating shaft 103 is provided with a rolling roller 104 and a torque roller 105, and the torque roller 105 is tightly attached to the rolling roller 104; the other end of the passive rotating shaft 103 is provided with a coupler 106, and the coupler 106 is connected to a stepping motor.
Specifically, the base 101 is mainly used for fixing the whole system or device, and the roller shaft support housing 102 is mainly used for supporting the passive rotating shaft 103 and other components such as the coupling 106 arranged on the passive rotating shaft 103; the driven rotating shaft 103 rotates mainly under the drive of the motor, and drives the winding roller 104 and the torque roller 105 to rotate together. The roller shaft support housing 102 in the embodiment is provided with an opening at the center thereof, and the passive rotation shaft 103 is inserted through the opening and fixed in the roller shaft support housing 102 through the roller, so that the passive rotation shaft 103 can rotate freely. The winding roller 104 is used for winding a microfluidic pipeline to be stretched, and in the embodiment, the microfluidic pipeline can be stretched in a clockwise rotation tightening mode and a counterclockwise rotation tightening mode through two microfluidic pipeline stretching systems; the winding roller 104 in the embodiment may also heat the micro-fluid pipeline wound thereon, and the winding roller 104 may be made of a heat conductive material, or a heating component may be disposed on the winding roller 104. The coupling 106 in the embodiment is mainly used for transmitting the torque of the stepping motor to the torque roller 105 and the winding roller 104; the stepping motor is mainly used for driving the torque roller 105 and the winding roller 104 to wind a micro-flow pipeline, such as a teflon pipeline. In the embodiment, the torque roller 105 is tightly attached to the circular side surface of the winding roller 104, the radius of the torque roller is slightly larger than the circular side surface of the winding roller 104, and the torque roller can be used for winding the microfluidic pipeline in a manual rotation mode.
In some alternative embodiments, the first surface of the winding roller is provided with a first heating film, the first heating film is used for heating the micro-fluid pipeline wound on the winding roller, and the first surface is a surface with a rectangular projection.
Specifically, the first surface in the embodiment is a rectangular side surface (the projection of the side surface is a rectangle) of the winding roller after being unfolded, the surface is firstly wrapped with a layer of heating film, the wound microfluidic pipeline is wound on the heating film for heating, and the temperature change of the heating film in the embodiment can be controlled by PID, so that the microfluidic pipeline obtained by stretching in the embodiment has higher accuracy, and meets the target requirement. It can be understood that a plurality of grooves can be arranged on the first surface at equal intervals, and the micro-flow pipeline can be prevented from sliding when being rolled.
In some optional embodiments, the stretching system further comprises a second heating film, the second heating film covers the surface of the microfluidic pipeline wound on the winding roller, and the second heating film is used for forming a heating film interlayer with the first heating film, and the heating film interlayer is used for heating the microfluidic pipeline.
Specifically, as shown in fig. 3, the second heating film in the embodiment is a heating film directly wound on the microfluidic pipeline or covered on the coiled microfluidic pipeline, and forms a heating film interlayer with the first heating film, that is, the heating film covered on the coiling roller, to heat the microfluidic pipeline, so as to obtain a better heating effect. In an exemplary embodiment, the heating film is wound by the winding roller, two ends of the microfluidic pipeline are fixed outside and wound on the heating film, and the microfluidic pipeline is covered by a layer of heating film again to form a wrapping effect, so that the microfluidic pipeline wrapped in the heating film is heated.
In some alternative embodiments, the stretching system further comprises a PID controller and a heating component, the PID controller is connected to the heating component, and the heating component is connected to the first heated film and/or the second heated film.
In particular, PID control is an abbreviation of proportional (contribution) Integral (Integral) derivative (Differential) and represents three control algorithms, respectively, and the deviation of temperature can be effectively corrected by the combination of the three algorithms, so that the temperature reaches a stable state. In the embodiment, the first heating film and/or the second heating film are/is controlled by the PID controller, so that the temperature control process is more stable, the temperature change is smoother, and the quality or the qualified rate of the stretched microfluidic pipeline is further improved.
In some alternative embodiments, as shown in fig. 1, the end of the coupling away from the passive rotating shaft is provided with a main rotating shaft 107, and the main rotating shaft 107 is used for fixing with the stepping motor and driving the passive rotating shaft through coaxial transmission.
Specifically, in the embodiment, the main rotating shaft 107 directly contacts with the stepping motor to be fixed, and the fixing manner includes, but is not limited to, bolt fixing or magnetic attraction fixing through a through hole of the shaft body; after the motor is started, the driving rotating shaft 107 is driven to rotate, so that the driven rotating shaft is driven to rotate, and finally the rolling roller is driven to rotate to roll the micro-flow pipeline.
In some alternative embodiments, the stretching system further comprises a temperature sensor disposed on the first surface; the temperature sensor is used for acquiring the temperature of the first heating film.
Specifically, in the embodiment, temperature data in the microfluidic pipeline or the heating film interlayer can be acquired through the arranged patch type temperature sensor, and the temperature data is transmitted back to the PID controller to be used as data feedback of dimension embodiment control, so that the timeliness and the accuracy of temperature control are higher.
In a second aspect, as shown in fig. 4, an embodiment of the present application further provides a microfluidic channel stretching method, where the method includes steps S100-S200:
s100, heating the microfluidic pipeline through a first heating film covered on the surface of a winding roller;
s200, driving a winding roller through a motor, and winding the heated micro-flow pipeline through the rotation of the winding roller so as to stretch the heated micro-flow pipeline;
specifically, a heating film is wound by a winding roller; then, the embodiment controls the stepping motor to drive the rotating shaft through the coupler, the micro-flow pipeline is wound through the winding roller at the front end of the rotating shaft, and meanwhile, the embodiment heats the micro-flow pipeline through the heating film. In addition, the embodiment can also pass through the shaft coupling, and then control this patent device and external step motor's opening and shutting.
In some optional embodiments, the microfluidic channel stretching method may further include step S110:
s110, heating the microfluidic pipeline through a heating film interlayer formed by the first heating film and the second heating film;
in an exemplary embodiment, the heating film is wound by the winding roller, two ends of the microfluidic pipeline are fixed outside and simultaneously wound on the heating film, and the microfluidic pipeline is covered with a layer of heating film again to form a wrapping effect.
In some alternative embodiments, as shown in fig. 5, the method may further include steps S300 and S400:
s300, determining that the rotating speed of the winding roller is greater than the rotating speed of the motor or the rotating speed of the winding roller is greater than a preset rotating speed threshold value, and controlling the passive rotating shaft to be separated from the coupler;
s400, driving a rolling roller through a torque roller, and rolling the heated micro-flow pipeline through the rolling roller to stretch the heated micro-flow pipeline.
Specifically, the embodiment acquires the rotating speed of the stepping motor in real time; when the rotating speed of the rotating shaft is higher than that of an external motor or is too high, the rotating shaft is disconnected with the coupling; when the rotating shaft is lower than the rotating speed of the motor, the rotating shaft rotates; the rotation of the rotating shaft drives the torque and the rolling roller to control the stretching of the micro-flow pipeline.
From the above specific implementation process, it can be concluded that the technical solution provided by the present invention has the following advantages or advantages compared to the prior art:
1. according to the scheme of the invention, the rotating speed is controlled by the stepping motor so as to control the tensile force born by the microfluidic pipeline, and the accuracy and reliability of the device are improved;
2. the heating film in the scheme of the invention adopts PID control, so that the temperature is stabilized at an upper interval and a lower interval and is only vibrated by about one degree centigrade, and the stability of the temperature is realized;
3. the scheme of the invention can be applied to cutting different pipeline positions after stretching to obtain pipelines with different thickness degrees, and when two different positions of the pipeline are used as liquid drops to transmit the Y-shaped pipeline, liquid drops with different sizes can be generated.
In alternative embodiments, the functions/acts noted in the block diagrams may occur out of the order noted in the operational illustrations. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality/acts involved. Furthermore, the embodiments presented and described in the flow charts of the present invention are provided by way of example in order to provide a more comprehensive understanding of the technology. The disclosed methods are not limited to the operations and logic flows presented herein. Alternative embodiments are contemplated in which the order of various operations is changed, and in which sub-operations described as part of larger operations are performed independently.
Furthermore, although the present invention is described in the context of functional modules, it should be understood that, unless otherwise specified to the contrary, one or more of the functions and/or features may be integrated in a single physical device and/or software module, or one or more functions and/or features may be implemented in separate physical devices or software modules. It will also be understood that a detailed discussion of the actual implementation of each module is not necessary for an understanding of the present invention. Rather, the actual implementation of the various functional modules in the apparatus disclosed herein will be understood within the ordinary skill of an engineer, given the nature, function, and internal relationship of the modules. Accordingly, those skilled in the art can, using ordinary skill, practice the invention as set forth in the claims without undue experimentation. It is also to be understood that the specific concepts disclosed are merely illustrative of and not intended to limit the scope of the invention, which is defined by the appended claims and their full scope of equivalents.
The logic and/or steps represented in the flowcharts or otherwise described herein, such as an ordered listing of executable instructions that can be considered to implement logical functions, can be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device, such as a computer-based system, processor-containing system, or other system that can fetch the instructions from the instruction execution system, apparatus, or device and execute the instructions.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. A micro-flow pipeline stretching system is characterized by comprising a substrate, a roller shaft supporting shell and a driven rotating shaft; the roller shaft supporting shell is fixed on the surface of the substrate; the driven rotating shaft is fixed in a roller of the roller shaft supporting shell; one end of the driven rotating shaft is provided with a rolling roller and a torque roller, and the torque roller is attached to the rolling roller; and the other end of the driven rotating shaft is provided with a coupler, and the coupler is connected to the stepping motor.
2. The stretching system as claimed in claim 1, wherein a first heating film is disposed on a first surface of the winding roller, the first heating film is used for heating the microfluidic pipeline wound on the winding roller, and the first surface is a surface with a rectangular projection.
3. The stretching system for the microfluidic pipeline according to claim 2, further comprising a second heating film covering the surface of the microfluidic pipeline wound on the winding roller, wherein the second heating film is configured to form a heating film interlayer with the first heating film, and the heating film interlayer is configured to heat the microfluidic pipeline.
4. The stretching system of claim 3, further comprising a PID controller and a heating element, wherein the PID controller is connected to the heating element, and the heating element is connected to the first heating film and/or the second heating film.
5. The microfluidic pipeline stretching system according to claim 1, wherein a main rotating shaft is disposed at an end of the coupling away from the passive rotating shaft, and the main rotating shaft is used for being fixed to the stepping motor and driving the passive rotating shaft through coaxial transmission.
6. The stretching system as claimed in claim 2, further comprising a temperature sensor disposed on the first surface; the temperature sensor is used for acquiring the temperature of the first heating film.
7. A stretching method of a microfluidic pipeline, applied to the stretching system of claim 1, comprising the steps of:
the micro-flow pipeline is heated through the first heating film covered on the surface of the rolling roller,
the motor drives the rolling roller, and the micro-flow pipeline after rolling and heating is rotated by the rolling roller so as to stretch and heat the micro-flow pipeline.
8. The microfluidic channel stretching method according to claim 7, further comprising the steps of;
covering a second heating film on the micro-flow pipeline coil wound by the winding roller;
and heating the microfluidic pipeline through a heating film interlayer formed by the first heating film and the second heating film.
9. The microfluidic channel stretching method as claimed in claim 7, further comprising the steps of:
acquiring the rotating speed of a motor;
and determining that the rotating speed of the winding roller is greater than the rotating speed of the motor, or determining that the rotating speed of the winding roller is greater than a preset rotating speed threshold value, and controlling the passive rotating shaft to be separated from the coupler.
10. The microfluidic channel stretching method according to any one of claims 7 to 9, further comprising the steps of:
the torque roller drives the rolling roller, and the micro-flow pipeline is rolled and heated by the rolling roller to be stretched and heated.
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| CN202210208865.1A CN114770912A (en) | 2022-03-03 | 2022-03-03 | Micro-flow pipeline stretching system and stretching method |
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| CN202210208865.1A CN114770912A (en) | 2022-03-03 | 2022-03-03 | Micro-flow pipeline stretching system and stretching method |
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| US20190062152A1 (en) * | 2016-03-03 | 2019-02-28 | National University Of Singapore | Versatile, Flexible And Biocompatible Elastomeric Microtubes |
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| CN111378573A (en) * | 2020-03-20 | 2020-07-07 | 中国科学院长春光学精密机械与物理研究所 | Micro-pipeline nucleic acid amplification system |
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