CN114767616A - Micro-nano motor based transportation method and application thereof - Google Patents

Micro-nano motor based transportation method and application thereof Download PDF

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Publication number
CN114767616A
CN114767616A CN202210228425.2A CN202210228425A CN114767616A CN 114767616 A CN114767616 A CN 114767616A CN 202210228425 A CN202210228425 A CN 202210228425A CN 114767616 A CN114767616 A CN 114767616A
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micro
light
nano
nano motor
driven
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李宇超
李宝军
张垚
宋婉莹
赵亚楠
徐嘉祺
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Jinan University
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Jinan University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023

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  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention belongs to the technical field of micro-nano motors, and discloses a micro-nano motor based transportation method and application thereof. The transportation method is non-contact and comprises the following steps: (1) adding a light-driven micro-nano motor which rotates in a motion mode into a solution containing an object to be transported; (2) and driving the light-driven micro-nano motor to rotate at a set position by adopting a light potential well, so that the solution around the object to be transported generates a set flow field, and the object to be transported is driven to move to a target position in a non-contact manner. The invention can realize the directional transportation of the object to be transported in a non-contact way by driving the micro-nano motor to rotate by the potential trap, and is particularly suitable for drug delivery in the field of biomedicine.

Description

Micro-nano motor based transportation method and application thereof
Technical Field
The invention belongs to the technical field of micro-nano motors, and particularly relates to a micro-nano motor based transportation method and application thereof.
Background
The micro-nano motor is a micro-nano scale device capable of converting external energy (such as chemical energy, light energy, sound energy, magnetic energy and the like) into kinetic energy. The micro-nano material with the self-driving characteristic has extremely wide development prospect in the fields of chemistry, biology, medical treatment, environment and the like. For example, in the field of medicine, micro-nano motors are adopted to realize drug loading and directional transportation on a micro-nano scale. At present, the micro-nano motor basically loads goods and then moves to a target position to release the goods, and the micro-nano motor belongs to a contact type transportation mode. Then, the biocompatibility of most of the existing micro-nano motors is insufficient, so that the targeted transportation of the cargos to the cells is not facilitated.
Therefore, the invention hopes to develop a method capable of realizing non-contact transportation based on the micro-nano motor technology so as to meet the requirement of realizing cargo transportation to cells.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art described above. Therefore, the invention provides a transportation method based on a micro-nano motor and application thereof. The invention can realize the directional transportation of the object to be transported in a non-contact way, and is particularly suitable for drug delivery in the biomedical field.
The invention provides a transportation method based on a micro-nano motor, which is in a non-contact type and comprises the following steps:
(1) adding a light-driven micro-nano motor which rotates in a motion mode into a solution containing an object to be transported;
(2) and driving the light-driven micro-nano motor to rotate at a set position by adopting a light potential well, so that the solution around the object to be transported generates a set flow field, and the object to be transported is driven to move to a target position in a non-contact manner.
Preferably, the number of the light-driven micro-nano motors is 2 or more. When the number of the optical driving micro-nano motors is 2, the optical driving micro-nano motors are driven to rotate clockwise and anticlockwise through the photo potential traps respectively, the rotating speed of the optical driving micro-nano motors is adjusted, and an object to be transported can be better driven to move to a target position.
Preferably, the substance to be transported is a drug.
Preferably, the composition material of the light-driven micro-nano motor comprises an up-conversion material. Because the exciting light of the up-conversion material is near infrared light, the optical biological penetrability of the wave band is strong, the damage to organisms is small, and the cargo transportation on the cell layer surface is facilitated.
More preferably. The light-driven micro-nano motor is made of at least one of medium microspheres, cells and metal particles.
More preferably, the up-conversion material is a rare earth up-conversion luminescent material. Further preferably, the rare earth up-conversion luminescent material is NaYF 4: Yb3+/Er3+Micro rod particles.
Preferably, the shape of the light-driven micro-nano motor is at least one of a T shape, a star shape, a cross shape and a flower shape.
Preferably, the preparation method of the light-driven micro-nano motor comprises the following steps:
(1) dispersing the upconversion material in water to obtain an upconversion material suspension;
(2) and assembling the upconversion material in the upconversion material suspension by adopting an optical tweezers system to obtain the optical drive micro-nano motor.
The invention also provides application of the transportation method in the field of material transportation. The transportation method has a wide application prospect in the field of biological medicine, and after cells are added into a solution containing the medicine, the non-contact transportation method can be adopted to transport the medicine to the cells in a targeted manner.
Compared with the prior art, the invention has the following beneficial effects:
(1) the invention adopts the up-conversion material as the component material of the micro-nano motor, the exciting light is near infrared light, the optical biological penetrability of the wave band is strong, and the damage to the organism is small;
(2) the non-contact type transportation method based on the micro-nano motor can realize the directional transportation of the object to be transported in a non-contact manner by driving the micro-nano motor to rotate through the optical potential well, and is particularly suitable for drug delivery in the field of biomedicine.
Drawings
FIG. 1 is a representation of an upconverting material; wherein, the figure a is an optical image of the up-conversion material under a scanning electron microscope; figure b is a microscope bright field image of the upconverting material; figure c is a microscope dark field image of the upconverting material; figure d is a length distribution plot of the upconverting material.
FIG. 2 is a diagram of an experimental apparatus for assembling and rotating a light-driven micro-nano motor; wherein, the drawing a is a drawing of an optical tweezers system device: 1. the device comprises a near infrared laser, 2, an acousto-optic modulation component, 3, a beam expander, 4, a dichroic mirror, 5, a filter, 6, an inverted objective lens, 7, a sample chamber, 8, a condenser, 9, an illumination light source and 10, and a CCD (charge coupled device) connected with a computer; b1-b4 are experimental diagrams of the precise manipulation of the rotation of the upconverting material by a single potential well of an optical tweezers system; fig. c is a microscope image of the light-driven micro-nano motor with the up-conversion material forming a T-shaped structure; fig. d is a microscope image of the light-driven micro-nano motor with the star-shaped structure formed by the up-conversion material; panel e is a microscope image of the assembly of upconverting material and yeast; and f, forming a microscope image of the three-dimensional structure light-driven micro-nano motor by the up-conversion material and the medium microspheres.
FIG. 3 is an experimental diagram of the optical tweezers system controlling the rotation of the optical driving micro-nano motor; in a drawing a1-a4, a micro-nano motor is optically driven by a single potential trap rotating cross-shaped structure of an optical tweezers system; in the diagrams b1-b4, the micro-nano motor is driven to rotate and transport single polystyrene particles by controlling a flower-shaped structure through a plurality of potential wells of the optical tweezers system, the center of the micro-nano motor is driven by fixing light through a single potential well, and a circular photo-potential well array is additionally arranged.
Fig. 4 is an experimental diagram of arranging optical driving micro-nano motors into an array and transporting particles by using an optical tweezers system; the graph a is an experimental graph of polystyrene particles transported by two light-driven micro-nano motors; b1-b2 are experimental diagrams of a plurality of light-driven micro-nano motors for rotating transportation and changing the moving direction of polystyrene particles; fig. c1-c3 are experimental diagrams of targeted transportation of polystyrene particles to cells by two light-driven micro-nano motors.
Detailed Description
In order to make the technical solutions of the present invention more apparent to those skilled in the art, the following examples are given for illustration. It should be noted that the following examples are only preferred embodiments of the present invention, and are not intended to limit the scope of the claims of the present invention, and any modifications, substitutions, combinations, and alterations made without departing from the spirit and principle of the present invention are all included in the scope of the present invention.
The starting materials, reagents or apparatuses used in the following examples are, unless otherwise specified, either commercially available from conventional sources or can be obtained by known methods.
Example 1
The embodiment provides a light-driven micro-nano motor, and the motion mode of the light-driven micro-nano motor is rotation. The manufacturing method of the optical drive micro-nano motor comprises the following steps:
(1) 0.003g of upconverter material (NaYF 4: Yb) was weighed out3+/Er3+Micro-rod particles) into a centrifuge tube containing 1mL of ultrapure water, and then placing the centrifuge tube into an ultrasonic oscillator for oscillation so as to obtain an upconversion material suspension.
FIG. 1 shows the up-conversion material (NaYF 4: Yb) in this example3+/Er3+Micro rod particles). Wherein, the graph a is an optical image of the up-conversion material under a scanning electron microscope; figure b is a microscope bright field image of the upconverting material; figure c is a microscope dark field image of the upconverting material; figure d is a length distribution graph of the upconverting material.
(2) A20. mu.L aliquot of upconverting material suspension was taken with a pipette and dropped onto a slide, which was fixed to the stage of the optical tweezers system. A near-infrared laser emitting at 1064nm was turned on, the laser power was adjusted to 90mW to 150mW, the laser was modulated in an acousto-optic modulator, and then expanded in a beam expander. The laser beam is expanded and then irradiates the dichroic mirror, enters the inverted objective lens after being reflected, and is finally focused into a sample in the sample chamber. Two light potential wells are respectively arranged at positions, close to two ends, of the up-conversion material vertical to the direction of the optical axis, one light potential well is used for fixing a fulcrum of the micro-rod, and the other light potential well controls the micro-rod to rotate, so that the angle of the micro-rod can be changed, and subsequent assembly is facilitated. And arranging a light potential well to capture the other up-conversion material, moving the micro-rod to the central position of the fixed micro-rod along the direction of the optical axis, keeping the operation still for 6 to 10 minutes, and assembling the two micro-rods together under the action of the light potential well. And removing the optical potential well to obtain the assembled T-shaped structure optical drive micro-nano motor, and assembling the optical drive micro-nano motor in other shapes by adopting the same method. The rotating angle of the up-conversion material can be accurately controlled through the optical tweezers system, and the micro motor with a two-dimensional and three-dimensional structure can be formed by the micro motor, biological bacteria, medium microspheres and the like. The experimental process can be recorded by CCD and displayed on a computer in real time.
Fig. 2 is a diagram of an experimental apparatus for assembling and rotating the optical driving micro-nano motor. Wherein, the drawing a is a drawing of an optical tweezers system device: 1. the device comprises a near infrared laser, 2, an acousto-optic modulation component, 3, a beam expander, 4, a dichroic mirror, 5, a filter, 6, an inverted objective lens, 7, a sample chamber, 8, a condenser, 9, an illumination light source and 10, and a CCD (charge coupled device) connected with a computer; b1-b4 are experimental diagrams of the precise manipulation of the rotation of the upconverting material by a single potential well of an optical tweezers system; fig. c is a microscope image of the light-driven micro-nano motor with the up-conversion material forming a T-shaped structure; fig. d is a microscope image of the light-driven micro-nano motor with the star-shaped structure formed by the up-conversion material; panel e is a microscope image of the assembly of upconverting material and yeast; and f, showing a microscope image of the light-driven micro-nano motor with a three-dimensional structure formed by the up-conversion material and the medium microspheres.
Example 2
In this embodiment, a single optical potential well and a plurality of optical potential wells are respectively arranged to rotate the optical driving micro-nano motor manufactured by the method in embodiment 1, and the specific method is as follows:
single light potential well: a photo potential trap is placed in the center of the assembled light-driven micro-nano motor with the cross structure, the laser power is set to 90mW, the light-driven micro-nano motor is stably captured and starts to rotate, the laser power is gradually adjusted, and the maximum laser power can be adjusted to 1 w. The results show that the light-driven micro-nano motor can be captured and rotated by utilizing a single light potential well, the rotating speed of the light-driven micro-nano motor can be adjusted by changing the laser power, and the rotating speed is flexibly adjusted.
A plurality of light potential wells: the light can be driven to drive the micro-nano motor to rotate through the plurality of potential wells, and the rotation direction of the light-driven micro-nano motor can be controlled. Firstly, moving a light potential well at the center of a pattern-structured light-driven micro-nano motor, turning on laser, fixing the micro motor, applying a circular light potential well, adjusting the diameter of the circular light potential well according to the diameter of the light-driven micro-nano motor to a diameter which can enable the light-driven micro-nano motor to stably rotate, dripping a polystyrene solution (the particle size of polystyrene is about 3 mu m) with the concentration of 0.5mg/mL into a sample bin when the light-driven micro-nano motor is stable in rotation, and driving the flow of surrounding fluid when the light-driven micro-nano motor rotates to drive polystyrene particles to move. The results show that the center of the light-driven micro-nano motor is fixed by using a single light potential well, and the circular light potential wells are added around the light-driven micro-nano motor, so that the rotating speed of the light-driven micro-nano motor can be changed by changing the laser scanning speed, and the rotating speed of the light-driven micro-nano motor is increased under the lower laser power.
Fig. 3 is an experimental diagram illustrating that an optical tweezers system is used to control light to drive a micro-nano motor to rotate. Wherein, a1-a4 shows that the micro-nano motor is optically driven by a single potential trap rotating cross-shaped structure of an optical tweezers system; in the diagrams b1-b4, the micro-nano motor is driven to rotate and transport single polystyrene particles by controlling a flower-shaped structure through a plurality of potential wells of the optical tweezers system, the center of the micro-nano motor is driven by fixing light through a single potential well, and a circular photo-potential well array is additionally arranged.
Example 3
In this embodiment, a plurality of light-driven micro-nano motors manufactured by the method in embodiment 1 are used to arrange and transport particles, and the particles are transported to a target position in a non-contact manner by using a flow field generated when the light-driven micro-nano motors rotate, and the specific method is as follows:
fig. 4 is an experimental diagram showing that the optical tweezers system is used to arrange the optical driving micro-nano motors into an array and transport particles. The graph a is an experimental graph of polystyrene particles transported by two light-driven micro-nano motors; b1-b2 are experimental diagrams of a plurality of light-driven micro-nano motors for rotating transportation and changing the moving direction of polystyrene particles; and fig. c1-c3 are experimental diagrams of targeted transportation of polystyrene particles to cells by two light-driven micro-nano motors.
As shown in a in fig. 4, a polystyrene solution (with a polystyrene particle size of about 3 μm) with a concentration of 0.5mg/mL is dropped into a sample bin, two circular optical potential wells in opposite directions are arranged on two assembled optical driving micro-nano motors, and the optical driving micro-nano motors respectively rotate clockwise and counterclockwise, so that polystyrene particles can be driven to move. As shown in b1 and b2 in fig. 4, when the number of the light-driven micro-nano motors is increased to 4, the positions of the light-driven micro-nano motors are adjusted, the left lower light-driven micro-nano motors are set to rotate clockwise, the light-driven micro-nano motors above and below the right are set to rotate anticlockwise, the laser scanning rate is adjusted to enable the rotating speed of the light-driven micro-nano motors to reach 4 revolutions per second, and the moving speed of polystyrene particles can reach 18 μm/s at most. By controlling the optical tweezers, the optical driving micro-nano motors can be arranged into different arrays, the transportation direction can be changed as required, and the polystyrene particles can be transported to a target position. As shown in FIG. 4, C1 to C3, cancer cell slides of cultured C127 cell line were taken, placed on a stage, and 1. mu.L of an upconverting material (NaYF 4: Yb) at a concentration of 3mg/mL was dropped onto the slides3+/Er3+Micro-rod particle) suspension, an up-conversion material is controlled by a light potential well to assemble an optical driving micro-nano motor, two light potential wells are arranged to capture the two optical driving micro-nano motors respectively, the optical driving micro-nano motor is moved to the side of a cell, a circular light potential well is added on the optical driving micro-nano motor to drive the optical driving micro-nano motor to start rotating, polystyrene particles are transported to the surface position of the cell from the vicinity of the cell, and therefore material transportation in the cell environment is achieved.
The embodiments of the present application have been described in detail with reference to the drawings, but the present application is not limited to the embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the gist of the present application. Furthermore, the embodiments and features of the embodiments of the present application may be combined with each other without conflict.

Claims (8)

1. A transportation method based on a micro-nano motor is characterized by being in a non-contact mode and comprising the following steps:
(1) adding a light-driven micro-nano motor which rotates in a motion mode into a solution containing an object to be transported;
(2) and driving the light-driven micro-nano motor to rotate at a set position by adopting a light potential well, so that the solution around the object to be transported generates a set flow field, and the object to be transported is driven to move to a target position in a non-contact manner.
2. The transportation method according to claim 1, wherein the number of the light-driven micro-nano motors is 2 or more.
3. The transportation method according to claim 1, wherein the substance to be transported is a drug.
4. The transportation method according to claim 1, wherein the constituent material of the light-driven micro-nano motor comprises an up-conversion material.
5. The transportation method according to claim 4, wherein the up-conversion material is a rare earth up-conversion luminescent material.
6. The transportation method according to claim 1, wherein the light-driven micro-nano motor is at least one of T-shaped, star-shaped, cross-shaped and flower-shaped.
7. The transportation method according to claim 1, wherein the preparation method of the light-driven micro-nano motor comprises the following steps:
(1) dispersing an upconverting material in water to obtain an upconverting material suspension;
(2) and assembling the upconversion material in the upconversion material suspension by adopting an optical tweezers system to obtain the optical drive micro-nano motor.
8. Use of the transport method according to claims 1-7 for targeted transport of a substance.
CN202210228425.2A 2022-03-07 2022-03-07 Micro-nano motor based transportation method and application thereof Pending CN114767616A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102268259A (en) * 2011-06-14 2011-12-07 中国科学院长春光学精密机械与物理研究所 Luminescent centre regionally doped rare earth upconversion luminescent material and preparation method thereof
CN102942933A (en) * 2012-11-30 2013-02-27 北京化工大学 In-water-phase monodisperse sodium yttrium tetrafluoride multi-color luminescent nanoparticle and preparation method thereof
US20190381490A1 (en) * 2016-11-07 2019-12-19 Hangzhou Tong-King Enviro-Tech Co., Ltd Composite photocatalysts, method for making the same and application thereof
CN113053556A (en) * 2021-03-10 2021-06-29 暨南大学 Biological micromotor array with reconfigurability and application thereof

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
CN102268259A (en) * 2011-06-14 2011-12-07 中国科学院长春光学精密机械与物理研究所 Luminescent centre regionally doped rare earth upconversion luminescent material and preparation method thereof
CN102942933A (en) * 2012-11-30 2013-02-27 北京化工大学 In-water-phase monodisperse sodium yttrium tetrafluoride multi-color luminescent nanoparticle and preparation method thereof
US20190381490A1 (en) * 2016-11-07 2019-12-19 Hangzhou Tong-King Enviro-Tech Co., Ltd Composite photocatalysts, method for making the same and application thereof
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