CN114767386A - Hydrogel eye protection patch and preparation method thereof - Google Patents

Hydrogel eye protection patch and preparation method thereof Download PDF

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Publication number
CN114767386A
CN114767386A CN202210450956.6A CN202210450956A CN114767386A CN 114767386 A CN114767386 A CN 114767386A CN 202210450956 A CN202210450956 A CN 202210450956A CN 114767386 A CN114767386 A CN 114767386A
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China
Prior art keywords
hydrogel
layer
woven fabric
adhesive tape
fabric layer
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Pending
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CN202210450956.6A
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Chinese (zh)
Inventor
何杰
史丙华
姜志华
罗文典
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Changsha Hairun Biological Technology Co ltd
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Changsha Hairun Biological Technology Co ltd
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Priority to CN202210450956.6A priority Critical patent/CN114767386A/en
Publication of CN114767386A publication Critical patent/CN114767386A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/12—Bandages or dressings; Absorbent pads specially adapted for the head or neck
    • A61F13/122—Bandages or dressings; Absorbent pads specially adapted for the head or neck specially adapted for the face
    • A61F13/124—Bandages or dressings; Absorbent pads specially adapted for the head or neck specially adapted for the face specially adapted for the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00655—Plasters adhesive
    • A61F2013/00676—Plasters adhesive hydrogel

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The hydrogel eye-protecting patch comprises a hydrogel layer, a medical adhesive tape layer and a non-woven fabric layer, wherein one side of the non-woven fabric layer is hydrophilic, and the other side of the non-woven fabric layer is water-repellent; the medical adhesive tape layer completely covers the arrangement positions of the hydrogel layer and the non-woven fabric layer, and is provided with an adhesive edge exceeding the arrangement positions of the hydrogel layer and the non-woven fabric layer. The hydrogel eye protection patch disclosed by the invention has the advantages of simple structure, reasonable arrangement, firm adhesion and the like, and the preparation method of the hydrogel eye protection patch also has the advantages of simple steps, convenience in implementation and the like.

Description

Hydrogel eye-protecting patch and preparation method thereof
Technical Field
The invention relates to the technical field of eye patch structures, in particular to a hydrogel eye patch and a preparation method thereof.
Background
The medical eye patch is mainly used for the outside of eyes of general anesthesia operation patients or deep coma patients, provides a relatively closed humid environment for the patients, prevents exposed keratitis, can also be used for protecting eyes, relieving fatigue, eliminating dark circles and the like. There is not fixing device in the eye patch on the present market, and direct wet aquogel or wet film cloth lean on the tension of water to adsorb, however the product of this kind of form is very little because of the adhesion, and the user of service needs the position of lying on the back, and other positions eye patches drop or drop easily, also has with the help of other fixed modes if use eye-shade or bandeau to be fixed in the head, but is more troublesome like this.
Disclosure of Invention
The hydrogel eye protection patch is simple in structure, reasonable in arrangement and firm in adhesion, and a method for preparing the hydrogel eye protection patch is simple in steps and convenient to implement.
In order to solve the technical problems, the technical scheme provided by the invention is as follows:
a hydrogel eye-protecting patch comprises a hydrogel layer, a medical adhesive tape layer and a non-woven fabric layer, wherein one side of the non-woven fabric layer is hydrophilic, and the other side of the non-woven fabric layer is water-repellent, the non-woven fabric layer is arranged between the medical adhesive tape layer and the hydrogel layer, is attached and connected with the hydrogel layer through a hydrophilic surface, and is attached and connected with a sticky surface of the medical adhesive tape layer through a water-repellent surface; the medical adhesive tape layer completely covers the arrangement positions of the hydrogel layer and the non-woven fabric layer, and is provided with an adhesive edge exceeding the arrangement positions of the hydrogel layer and the non-woven fabric layer.
As a further improvement of the hydrogel eye protection patch:
the hydrogel layer comprises a hydrogel application sheet and hydrogel edge sealing, the hydrogel application sheet is attached to the hydrophilic surface of the non-woven fabric layer, the hydrogel edge sealing is connected to the edge of the non-woven fabric layer and is of an annular structure surrounding the hydrogel application sheet, and the thickness of the hydrogel edge sealing is larger than that of the hydrogel application sheet.
The sticking edge is a semi-surrounding structure which starts from the canthus position to the under-eye position and extends to the tail of the eye position.
The hydrogel eye-protecting mask also comprises a release film, wherein the release film is attached to the surface of the medical adhesive tape layer with the hydrogel layer and the non-woven fabric layer.
The middle part of the hydrogel eye-protecting patch is provided with a through hole which penetrates through the hydrogel layer, the non-woven fabric layer and the medical adhesive tape layer.
A method for preparing the hydrogel eye patch comprises the following steps:
s1: injecting glue: pouring/injecting the hydrogel solution into a hydrogel layer forming die, laying a non-woven fabric layer on the surface of the solution, and applying the hydrophilic surface on the solution with the water-repellent surface facing outwards;
s2: molding: repeatedly freezing and thawing the product obtained in the step S1 for 3-6 times to form a hydrogel layer with a non-woven fabric layer;
s3: and (3) completing: and sticking the water-repellent surface of the non-woven fabric layer to the corresponding medical adhesive tape layer, bagging and sterilizing.
As a further improvement of the above preparation method:
before step S1, step S0 is further included: preparing hydrogel: weighing 0.2kg of water-soluble chitosan and 2.0kg of glycerol, adding 15kg of purified water, stirring and dissolving to prepare a chitosan solution for later use; taking 2.0kg of polyvinyl alcohol, adding 5kg of purified water, heating to 90-95 ℃, stirring and dissolving to prepare a polyvinyl alcohol solution, and cooling; mixing the chitosan solution and the polyvinyl alcohol solution, and stirring uniformly for later use.
In the process of freezing and thawing, the freezing temperature is-20 ℃ to-40 ℃.
Compared with the prior art, the invention has the advantages that:
the hydrogel eye protection patch comprises a medical adhesive tape layer and a non-woven fabric layer, wherein one side of the non-woven fabric layer is hydrophilic, the other side of the non-woven fabric layer is water-repellent, the non-woven fabric layer is arranged between the medical adhesive tape layer and the hydrogel layer, the hydrophilic surface is attached and connected with the hydrogel layer, the water-repellent surface is attached and connected with the adhesive surface of the medical adhesive tape layer, the medical adhesive tape layer completely covers the arrangement positions of the hydrogel layer and the non-woven fabric layer, and an adhesive edge exceeding the arrangement positions of the hydrogel layer and the non-woven fabric layer is arranged. In the arrangement mode, due to the medical adhesive tape layer, compared with single hydrogel or additional fixing equipment, the medical adhesive tape can play a good fixing role, complex operation steps are avoided, a user can walk freely in the using process, and the using feeling of the user is optimized. And owing to adopted the hydrophilic non-woven fabrics layer of water, one side is refused, the hydrophilic side of non-woven fabrics layer can firmly be fixed together with the hydrogel layer, avoids the hydrogel layer to break away from, and inside liquid infiltration to the non-woven fabrics layer in the aquogel, but under the block of the surface of refusing water, can not see through the non-woven fabrics layer again, avoids liquid to moisten medical adhesive tape layer, leads to it to lose viscidity, just because so, the laminating that the water repellent surface of non-woven fabrics can be better is on medical adhesive tape layer, has further strengthened the adhesion effect.
The preparation method provided by the invention also has the advantages of simple steps and convenience in implementation.
Drawings
Fig. 1 is a schematic structural view of the hydrogel eye patch of example 1;
fig. 2 is a schematic cross-sectional view of the hydrogel eye patch of example 1;
fig. 3 is a schematic cross-sectional view of the hydrogel eye patch of example 2.
Illustration of the drawings: 1. a hydrogel layer; 11. a hydrogel dressing; 12. edge sealing of the hydrogel; 2. a medical adhesive tape layer; 21. pasting the edge; 3. a non-woven fabric layer.
Detailed Description
In order to facilitate an understanding of the invention, reference will now be made in detail to the present preferred embodiments of the invention, examples of which are illustrated in the accompanying drawings, and the scope of the invention is not limited to the following specific embodiments.
Example 1:
as shown in fig. 1 and 2, the hydrogel eye-protecting patch of the embodiment includes a hydrogel layer 1, a medical adhesive tape layer 2, and a non-woven fabric layer 3 having one hydrophilic side and the other water-repellent side, where the non-woven fabric layer 3 is disposed between the medical adhesive tape layer 2 and the hydrogel layer 1, and is bonded to the hydrogel layer 1 through a hydrophilic surface, and bonded to a sticky surface of the medical adhesive tape layer 2 through a water-repellent surface; the medical adhesive tape layer 2 completely covers the arrangement positions of the hydrogel layer 1 and the non-woven fabric layer 3, and is provided with an adhesive edge 21 which exceeds the arrangement positions of the hydrogel layer and the non-woven fabric layer. In the arrangement mode, due to the medical adhesive tape layer 2, compared with a single hydrogel or an additional fixing device, the medical adhesive tape can play a good fixing role, complex operation steps are avoided, a user can walk freely in the using process, and the using feeling of the user is optimized. And owing to adopted the hydrophilic non-woven fabrics layer 3 that one side was refused water, the hydrophilic side of non-woven fabrics layer 3 can firmly be fixed together with hydrogel layer 1, avoid hydrogel layer 1 to break away from, and inside liquid penetration nonwoven fabrics layer 3 in the aquogel, but under the blockking of water repellent surface, can not see through non-woven fabrics layer 3 again, avoid liquid to moisten medical adhesive tape layer 2, lead to it to lose viscidity, just so, the laminating that water repellent surface of non-woven fabrics can be better is on medical adhesive tape layer 2, the effect of adhesion has further been strengthened.
In this embodiment, the nonwoven fabric layer 3 may be treated with different treatment processes on two side surfaces or bonded with different materials on two side surfaces to achieve the effects of hydrophilic one side and water repellent one side. When different treatment processes are adopted, one side of the water-repellent coating can be coated, and the other side of the water-repellent coating can be subjected to surface hydrophilic treatment, so that the surface hydrophilic treatment and the coating of the water-repellent coating belong to more conventional processes, and are not described herein again. When different fabrics are adopted, one side of the fabric can adopt a hydrophilic fabric such as cotton, and the other side of the fabric adopts a water repellent fabric such as PP (polypropylene), and the hydrophilic fabric and the PP (polypropylene) are jointed by physical entanglement between fibers, and the jointing process belongs to a conventional process and is not described herein.
In this embodiment, the hydrogel layer 1 includes a hydrogel sheet 11 and a hydrogel edge seal 12, the hydrogel sheet 11 is attached to the hydrophilic surface of the nonwoven fabric layer 3, the hydrogel edge seal 12 is connected to the edge of the nonwoven fabric layer 3, and for enclosing the annular structure of the hydrogel sheet 11, the thickness of the hydrogel edge seal 12 is greater than the thickness of the hydrogel sheet 11. The slightly thicker hydrogel edge seal 12 completely isolates the skin of the eye from the hydrogel patch 11 from the outside, enhances the sealing property, and blocks external microbial bacteria.
In this embodiment, the pasting edge 21 is a semi-surrounding structure starting from the corner of the eye to the under-eye position and extending to the tail of the eye, and does not involve the upper part of the eye, so that the firmness of the pasting can be ensured, eyebrows cannot be adhered when the eye paste is removed, and pain of users is avoided.
In this embodiment, the hydrogel eye-protecting patch further comprises a release film, and the release film is attached to the surface of the medical adhesive tape layer 2 with the hydrogel layer 1 and the non-woven fabric layer 3, so as to achieve the effect of isolation and sealing.
In the embodiment, the middle part of the hydrogel eye protection paste is not provided with the through hole, so that the eye protection paste is used for patients with general anesthesia operation or patients with deep coma, and the patients are unconscious in the use scene, so that the structure without the through hole is sealed, and the moisturizing effect of the eye protection paste can be ensured.
The method for preparing the hydrogel eye patch comprises the following steps:
s0: preparing a hydrogel: weighing 0.2kg of water-soluble chitosan and 2.0kg of glycerol, adding 15kg of purified water, stirring and dissolving to prepare a chitosan solution for later use; taking 2.0kg of polyvinyl alcohol, adding 5kg of purified water, heating to 90-95 ℃, stirring and dissolving to prepare a polyvinyl alcohol solution, and cooling; mixing chitosan solution and polyvinyl alcohol solution, and stirring uniformly for later use;
s1: injecting glue: pouring/injecting the solution obtained in the step S0 into a hydrogel layer 1 forming die, laying a non-woven fabric layer 3 on the surface of the solution, and applying a hydrophilic surface on the solution with the water-repellent surface facing outwards; so that the non-woven fabric is well contacted with the solution before gel forming in the next freezing and thawing process, the solution can permeate into the non-woven fabric and cannot permeate through the non-woven fabric, and the gel can be firmly integrated with the non-woven fabric and cannot be separated after the gel is formed by the freezing and thawing solution;
s2: molding: repeatedly freezing and thawing the product obtained in the step S1 for 3-6 times at the freezing temperature of-20 ℃ to-40 ℃ to form a hydrogel layer 1 with a nonwoven fabric layer 3;
s3: and (3) completing: and (3) sticking the water-repellent surface of the non-woven fabric layer 3 to the corresponding medical adhesive tape layer 2, bagging and sterilizing.
Example 2:
the present embodiment is substantially the same as embodiment 1, except that, as shown in fig. 3, a through hole penetrating through the hydrogel layer 1, the nonwoven fabric layer 3 and the medical tape layer 2 is formed in the middle of the hydrogel eye-protecting patch in the present embodiment. Although the arrangement mode is communicated with the environment, the effects of moisturizing and water replenishing of the product are influenced to a certain extent, the eye-using of a user is facilitated, and the activity of the user is not influenced.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above-described embodiments. It should be apparent to those skilled in the art that modifications and variations can be made without departing from the technical spirit of the present invention.

Claims (8)

1. The utility model provides a aquogel eyeshield subsides, includes aquogel layer (1), its characterized in that: the medical adhesive tape is characterized by further comprising a medical adhesive tape layer (2) and a non-woven fabric layer (3) with one hydrophilic side and the other water-repellent side, wherein the non-woven fabric layer (3) is arranged between the medical adhesive tape layer (2) and the hydrogel layer (1), is attached and connected with the hydrogel layer (1) through a hydrophilic surface, and is attached and connected with a sticky surface of the medical adhesive tape layer (2) through a water-repellent surface; the medical adhesive tape layer (2) completely covers the arrangement positions of the hydrogel layer (1) and the non-woven fabric layer (3), and is provided with an adhesive edge (21) which exceeds the arrangement positions of the hydrogel layer and the non-woven fabric layer.
2. The hydrogel eye protector of claim 1, wherein: the hydrogel layer (1) comprises a hydrogel application sheet (11) and hydrogel edge seals (12), the hydrogel application sheet (11) is attached to the hydrophilic surface of the non-woven fabric layer (3), the hydrogel edge seals (12) are connected to the edges of the non-woven fabric layer (3) and are of an annular structure surrounding the hydrogel application sheet (11), and the thickness of the hydrogel edge seals (12) is larger than that of the hydrogel application sheet (11).
3. The hydrogel eye protector of claim 1, wherein: the sticking edge (21) is a semi-surrounding structure which starts from the canthus position to the under-eye position and extends to the tail of the eye position.
4. The hydrogel eye protector of claim 3, wherein: the medical adhesive tape is characterized by further comprising a release film, wherein the release film is attached to the surface of the medical adhesive tape layer (2) with the hydrogel layer (1) and the non-woven fabric layer (3).
5. The hydrogel eye patch according to claim 1, wherein: the middle part of the hydrogel eye-protecting patch is provided with a through hole which penetrates through the hydrogel layer (1), the non-woven fabric layer (3) and the medical adhesive tape layer (2).
6. A method for preparing the hydrogel eye patch according to any one of claims 1 to 5, comprising the steps of:
s1: injecting glue: pouring/injecting the hydrogel solution into a hydrogel layer (1) forming die, laying a non-woven fabric layer (3) on the surface of the solution, and applying the hydrophilic surface on the solution with the water-repellent surface facing outwards;
s2: molding: repeatedly freezing and thawing the product obtained in the step S1 for 3-6 times to form a hydrogel layer (1) with a non-woven fabric layer (3);
s3: and (3) completing: and (4) sticking the water-repellent surface of the non-woven fabric layer (3) to the corresponding medical adhesive tape layer (2), bagging and sterilizing.
7. The method for preparing the hydrogel eye patch according to claim 6, wherein step S1 is preceded by step S0: preparing hydrogel: weighing 0.2kg of water-soluble chitosan and 2.0kg of glycerol, adding 15kg of purified water, stirring and dissolving to prepare a chitosan solution for later use; taking 2.0kg of polyvinyl alcohol, adding 5kg of purified water, heating to 90-95 ℃, stirring and dissolving to prepare a polyvinyl alcohol solution, and cooling; mixing the chitosan solution and the polyvinyl alcohol solution, and stirring uniformly for later use.
8. The method of claim 6, wherein the hydrogel eye patch is formed by: in the process of freeze thawing, the freezing temperature is-20 ℃ to-40 ℃.
CN202210450956.6A 2022-04-26 2022-04-26 Hydrogel eye protection patch and preparation method thereof Pending CN114767386A (en)

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Application Number Priority Date Filing Date Title
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4730611A (en) * 1986-09-02 1988-03-15 Absorbent Cotton Company Medical dressing device
US5154928A (en) * 1989-02-23 1992-10-13 Uhra Laboratories Limited Wound dressing
CN1946826A (en) * 2004-04-22 2007-04-11 积水化成品工业株式会社 Gel adhesive composition
CN103494668A (en) * 2013-09-30 2014-01-08 长沙海润生物技术有限公司 Medical hydrogel moisturizing eye care mask and preparation method thereof
CN209332485U (en) * 2018-11-19 2019-09-03 江苏昌吉永生物科技股份有限公司 A kind of local visual hydrogel eye paste

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4730611A (en) * 1986-09-02 1988-03-15 Absorbent Cotton Company Medical dressing device
US5154928A (en) * 1989-02-23 1992-10-13 Uhra Laboratories Limited Wound dressing
CN1946826A (en) * 2004-04-22 2007-04-11 积水化成品工业株式会社 Gel adhesive composition
CN103494668A (en) * 2013-09-30 2014-01-08 长沙海润生物技术有限公司 Medical hydrogel moisturizing eye care mask and preparation method thereof
CN209332485U (en) * 2018-11-19 2019-09-03 江苏昌吉永生物科技股份有限公司 A kind of local visual hydrogel eye paste

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