CN114748705A - 一种镀金属膜的聚合物支架及其制备方法 - Google Patents
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- A61L2420/00—Materials or methods for coatings medical devices
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Abstract
本发明公开了一种镀金属膜的聚合物支架及其制备方法,先用激光雕刻对聚合物纳米纤维管材进行雕刻,获得所需支架;然后利用低温等离子处理支架表面;最后在支架表面进行镀膜,工艺简单,操作简便,易于控制,有效改善聚合物支架的显影性,金属膜的厚度可调,成本低,同时提高了支架的机械性能,扩大了其使用范围。
Description
技术领域
本发明属于血管支架领域,具体涉及一种镀金属膜的聚合物支架及其制备方法。
背景技术
可降解支架包括可降解金属支架和高分子聚合物支架,经过一定周期后将逐步降解消失。其中,可降解金属支架多以Fe、Mg为基体材料,虽然机械性能优于聚合物支架,但这些金属支架的降解周期及降解产物类型仍需进一步研究;而可降解聚合物支架的降解产物在人体无副作用,但由于材料本身的限制,缺乏显影性,支撑强度小于金属支架,同时作为粘弹性材料,容易导致血栓形成。
针对聚合物支架显影较差的问题,目前大多通过压制铂标记点来改善,但由于材料本身较脆,容易出现断裂、脱落的问题,需要进一步的改进。
发明内容
为解决上述问题,本发明公开了一种镀金属膜的聚合物支架及其制备方法,工艺简单,操作简便,易于控制,有效改善聚合物支架的显影性,金属膜的厚度可调,成本低,同时提高了支架的机械性能,扩大了其使用范围。
为达到上述目的,本发明的技术方案如下:
一种镀金属膜的聚合物支架,其表面设有金属膜。
本发明所述的聚合物支架的材料为聚乳酸、聚丙烯或聚苯乙烯的其中一种聚合物。
本发明所述的聚合物支架,所述金属膜为钴、镍、钛、铜的其中一种金属或几种合金。
本发明所述的聚合物支架,所述金属膜的厚度为5nm-0.5μm。
本发明提供了一种镀金属膜的聚合物支架的制备方法,其工艺流程如下:
(1)用激光雕刻对聚合物纳米纤维管材进行雕刻,获得所需支架;
(2)利用低温等离子处理支架表面;
(3)在支架表面进行镀膜。
本发明所述的制备方法中,步骤(1)所述的聚合物纳米纤维管材的直径是2-8mm。
本发明所述的制备方法中,步骤(2)所述的低温等离子处理采用的等离子是Ar、N2、O2。
本发明所述的制备方法中,步骤(3)所述的镀膜方法是化学镀膜法。
本发明的有益效果为:
1.通过在支架表面镀金属膜能够有效改善聚合物支架的显影性,同时提高了支架的机械性能,扩大了其使用范围;
2.通过上述方法制备的含金属膜的支架成本相对较低,且通过调控低温等离子处理的参数以及还原剂的含量可以有效地调控金属膜的厚度,以便适应不同规格的支架需求;
3.低温等离子处理技术工艺简单,操作简便、易于控制,有效改善材料表面性质。
具体实施方式
下面结合具体实施方式,进一步阐明本发明,应理解下述具体实施方式仅用于说明本发明而不用于限制本发明的范围。
实施例1
一种镀金属膜的聚合物支架的制备方法,包括以下步骤:
1.用激光雕刻对聚乳酸管材进行雕刻,获得所需支架;
2.将支架置于异丙醇中超声清洗1min、干燥支架;
3.低温等离子体(Ar)处理聚乳酸材料表面:将支架置于反应腔内,待体系压力达到5Pa时通入Ar,调节流量至100mL/min,保持体系压力在20Pa,利用低温等离子处理使其具有亲水性官能团;
4.将支架浸入以1:1混合的氯化钯、氯化亚锡溶液中5min,使支架吸附钯、锡;
5.活化处理:将支架浸入的稀盐酸溶液(2mol/L)中3min;
6.采用化学镀膜法,对支架进行镀膜处理:将支架浸入含甲醛、镍的溶液中,利用甲醛作为还原剂沉积金属镍,待镀金属离子聚集在聚合物材料的表面,从而制得金属膜,本实施例制得的金属膜厚度为80nm,力学性能达到185MPa。
实施例2
一种镀金属膜的聚合物支架的制备方法,包括以下步骤:
1.用激光雕刻对聚丙烯管材进行雕刻,获得所需支架;
2.将支架置于异丙醇中超声清洗2min、干燥支架;
3.低温等离子体(O2)处理聚丙烯材料表面:将支架置于反应腔内,待体系压力达到5Pa时通入O2,调节流量至100mL/min,处理5min后取出,置于空气中20min,使自由基尽可能转化;
4.将支架浸入以1:1混合的氯化钯、氯化亚锡溶液中5min,使支架吸附钯、锡;
5.活化处理:将支架浸入的稀盐酸溶液(2mol/L)中3min;
6.采用化学镀膜法,对支架进行镀膜处理:将支架浸入含甲醛、镍的溶液中,利用甲醛作为还原剂沉积金属镍,待镀金属离子聚集在聚合物材料的表面,从而制得金属膜,本实施例制得的金属膜厚度为0.2μm,力学性能可达115MPa。
实施例3
一种镀金属膜的聚合物支架的制备方法,包括以下步骤:
1.用激光雕刻对聚苯乙烯管材进行雕刻,获得所需支架;
2.将支架置于异丙醇中超声清洗2min、干燥支架;
3.低温等离子体(CO2)处理聚苯乙烯材料表面:将支架置于反应腔内,调节流量至50mL/min,保持常压条件,利用低温等离子处理使其具有大量含氧自由基;
4.将支架浸入以1:1混合的氯化钯、氯化亚锡溶液中5min,使支架吸附钯、锡;
5.活化处理:将支架浸入的稀盐酸溶液(2mol/L)中3min;
6.采用化学镀膜法,对支架进行镀膜处理:将支架浸入含甲醛、镍的溶液中,利用甲醛作为还原剂沉积金属镍,待镀金属离子聚集在聚合物材料的表面,从而制得金属膜,本实施例制得的金属膜厚度为55nm,力学性能为92MPa。
本发明在聚合物材料表面涂覆金属膜使其兼具部分金属的特性,改善聚合物显影性,扩大材料的应用。
需要说明的是,以上内容仅仅说明了本发明的技术思想,不能以此限定本发明的保护范围,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰均落入本发明权利要求书的保护范围之内。
Claims (8)
1.一种镀金属膜的聚合物支架,其特征在于:聚合物支架表面设有金属膜。
2.根据权利要求1所述的一种镀金属膜的聚合物支架,其特征在于:所述的聚合物支架的材料为聚乳酸、聚丙烯或聚苯乙烯的其中一种聚合物。
3.根据权利要求1所述的一种镀金属膜的聚合物支架,其特征在于:所述金属膜为钴、镍、钛、铜的其中一种金属或几种合金。
4.根据权利要求1所述的一种镀金属膜的聚合物支架,其特征在于:所述金属膜的厚度为5nm-0.5μm。
5.根据权利要求1所述的一种镀金属膜的聚合物支架的制备方法,其特征在于:其工艺流程如下:
(1)用激光雕刻对聚合物纳米纤维管材进行雕刻,获得所需支架;
(2)利用低温等离子处理支架表面;
(3)在支架表面进行镀膜。
6.根据权利要求5所述的一种镀金属膜的聚合物支架的制备方法,其特征在于:步骤(1)所述的聚合物纳米纤维管材的直径是2-8mm。
7.根据权利要求5所述的一种镀金属膜的聚合物支架的制备方法,其特征在于:步骤(2)所述的低温等离子处理采用的等离子是Ar、N2、O2。
8.根据权利要求5所述的一种镀金属膜的聚合物支架的制备方法,其特征在于:步骤(3)所述的镀膜方法是化学镀膜法。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6322588B1 (en) * | 1999-08-17 | 2001-11-27 | St. Jude Medical, Inc. | Medical devices with metal/polymer composites |
CN105232193A (zh) * | 2015-08-19 | 2016-01-13 | 北京迈迪顶峰医疗科技有限公司 | 一种肺动脉支架 |
CN106492293A (zh) * | 2016-11-18 | 2017-03-15 | 南京理工大学 | 一种生物支架用钛微型管材的制备方法 |
CN107607071A (zh) * | 2017-09-26 | 2018-01-19 | 深圳市领先医疗服务有限公司 | 可降解药物涂层支架涂层厚度的测量方法 |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6322588B1 (en) * | 1999-08-17 | 2001-11-27 | St. Jude Medical, Inc. | Medical devices with metal/polymer composites |
CN105232193A (zh) * | 2015-08-19 | 2016-01-13 | 北京迈迪顶峰医疗科技有限公司 | 一种肺动脉支架 |
CN106492293A (zh) * | 2016-11-18 | 2017-03-15 | 南京理工大学 | 一种生物支架用钛微型管材的制备方法 |
CN107607071A (zh) * | 2017-09-26 | 2018-01-19 | 深圳市领先医疗服务有限公司 | 可降解药物涂层支架涂层厚度的测量方法 |
Non-Patent Citations (1)
Title |
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蔡珣 等主编: "《现代薄膜材料与技术》", 30 September 2007, 华东理工大学出版社 * |
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