CN114732779A - Whitening, moisturizing and bacteriostatic external composition as well as preparation method and application thereof - Google Patents
Whitening, moisturizing and bacteriostatic external composition as well as preparation method and application thereof Download PDFInfo
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- CN114732779A CN114732779A CN202210272725.0A CN202210272725A CN114732779A CN 114732779 A CN114732779 A CN 114732779A CN 202210272725 A CN202210272725 A CN 202210272725A CN 114732779 A CN114732779 A CN 114732779A
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Abstract
The invention discloses an external composition for whitening, moisturizing and inhibiting bacteria, a preparation method and application thereof, wherein the composition is W1/O/W2 type double emulsion; wherein, the W2 phase is an external water phase, the O phase is an intermediate oil phase, and the W1 phase is an internal water phase; the W1 phase comprises a yeast extract and/or lactobacillus fermentation product filtrate; the O phase comprises essential oil, oil and fat and lipophilic emulsifier; the W2 phase comprises a skin conditioning agent, a hydrophilic surfactant, a thickening agent and water; the external composition combines probiotics such as a yeast extract and a lactobacillus fermentation product filtrate with essential oil and grease, protects the probiotics from oxidation, can effectively regulate skin feel, and does not have greasy feeling. The external composition is prepared by a double-T-shaped microfluidic device, and double emulsion drops produced by the method have good uniformity and high wrapping rate.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an external composition for whitening, moisturizing and inhibiting bacteria, and a preparation method and application thereof.
Background
With the development of science and technology, the understanding of probiotics is more and more deep, and people find that the probiotics also has a good protection effect on the skin, can help the skin to resist the invasion of pathogenic bacteria and enhance the epithelial barrier function. Such as lactobacillus, has effects of improving skin diseases such as acne and dermatitis, repairing damaged skin, and slowing down skin aging. Currently, there are two main skin care products for probiotics: one is to directly utilize the metabolite of the probiotics, and the other is to add prebiotics (components which have promoting effect on the growth of the probiotics) as components into the product, thereby promoting the growth of the original probiotics of the skin. The existing skin care product added with the essential oil has higher manufacturing cost, and the essential oil can be supplemented with vegetable oil as a substrate, so that the risk of acne can be caused. However, combining prebiotics with essential oils and vegetable oils, which are not miscible, can result in unstable product texture, and dispersions formed from incompatible two-phase solutions can be made into oil-in-water or water-in-oil type dispersions, or double emulsions, i.e., smaller dispersions in immiscible two-phase dispersions.
The traditional double-emulsion drop preparation method is a two-step stirring method, namely, a hydrophobic emulsifier is added into the mixed solution to prepare W/O single emulsion, and then the single emulsion is placed into a water phase to be further changed into double-emulsion drops under the action of the emulsifier. In the method, the dispersed phase is broken into droplets under the action of shearing force and impact force generated by stirring and the droplets are distributed in the continuous phase, and the formation of the droplets is mainly related to factors such as a stress area, fluid physical properties, interfacial tension and the like. However, the fluid flow in the stirring area of the method is in a disordered state, and the spatial stress cannot be accurately regulated, so that the generated droplets are poor in uniformity, wide in size distribution and low in wrapping rate.
Disclosure of Invention
In order to overcome the defects of the prior art, one of the purposes of the invention is to provide an external composition for whitening, moisturizing and inhibiting bacteria, which is prepared by preparing prebiotics (a bifidus yeast extract and lactobacillus fermentation product filtrate), a skin conditioner and essential oil into W1/O/W2 type double emulsion, so that the skin feel is improved while the activity of probiotics is maintained; the invention also aims to provide a preparation method of the whitening, moisturizing and bacteriostatic external composition, wherein the double emulsion is prepared by a double-T-shaped microfluidic device, so that the W2 phase is uniformly wrapped on the innermost layer and is mutually isolated from the O phase and the W1 phase, and the activity of the components can be effectively kept; the invention also aims to provide application of the whitening, moisturizing and bacteriostatic external composition, which can be used as one of raw materials of cosmetics, added into cream, emulsion, essence and facial mask and has wide application range.
One of the purposes of the invention is realized by adopting the following technical scheme:
a whitening, moisturizing and bacteriostatic external composition is W1/O/W2 type double emulsion; wherein, the W2 phase is an external water phase, the O phase is an intermediate oil phase, and the W1 phase is an internal water phase; the W1 phase comprises a yeast extract and/or lactobacillus fermentation product filtrate; the O phase comprises essential oil, oil and fat and lipophilic emulsifier; the W2 phase comprises skin conditioning agent, hydrophilic surfactant, thickening agent and water.
Further, the skin conditioner is one or more of kapok extract, schizophyllan, rice fermentation product filtrate and distiller's grains extract.
Still further, the oil is one or a combination of more than two of squalene, squalane, jojoba oil, prinsepia utilis royle oil, wheat germ oil, sunflower seed oil, cottonseed oil, corn oil, olive oil, tea tree oil, palm oil, soybean oil, rose hip oil, evening primrose oil, cod liver oil, pumpkin seed oil, safflower oil, camellia oil, clove stem and leaf oil, clove oil, eugenol, vitamin E succinate, vitamin E acetate and light liquid paraffin.
Further, the essential oil is one or more of rosemary essential oil, geranium essential oil, tea tree essential oil, frankincense essential oil, rose essential oil, lavender essential oil, chamomile essential oil, citronella essential oil and verbena essential oil.
Still further, the lipophilic emulsifier is one or more of acacia, lecithin, soybean phospholipid, sorbitan sesquioleate, sorbitan monostearate, polyethylene glycol dioleate, polyoxyethylene stearate, polyoxyethylene fatty alcohol ether, and polyoxyethylene (30) dipolyhydroxystearate.
Further, the hydrophilic surfactant is one or a combination of more than two of polyoxyethylene monolaurate, polyoxyethylene lauryl ether, polyoxyethylene monopalmitate, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, tween 60, tween 65, tween 80, tween 85, poloxamer, polyvinyl alcohol, sodium dodecyl sulfate, caprylic/capric polyethylene glycol glyceride, polyethylene glycol-15 hydroxystearate, polyethylene glycol 300, polyethylene glycol 400, ethanol, propylene glycol and stearyl alcohol.
Still further, the whitening, moisturizing and bacteriostatic external composition comprises the following raw materials in percentage by weight:
the W1 phase is 1-5 wt% of a yeast schizophyllum bifidum extract and 1-5 wt% of a lactobacillus fermentation product filtrate;
the O phase comprises 0.1-0.5 wt% of essential oil, 20-30 wt% of grease and 5-10 wt% of lipophilic emulsifier;
the W2 phase comprises 15-30 wt% of a skin conditioner, 5-10 wt% of a hydrophilic surfactant, 1-2 wt% of a thickening agent and water; make up to 100 wt% from the water in the W2 phase. Preferably, the skin conditioner is 5-10 wt% of kapok extract, 5-10 wt% of schizophyllan polysaccharide and 5-10 wt% of rice fermentation product filtrate and/or distiller's grains extract.
The second purpose of the invention is realized by adopting the following technical scheme:
the preparation method of the whitening, moisturizing and bacteriostatic external composition comprises the following steps:
1) injecting W1 phase fluid, O phase fluid and W2 phase fluid into a T-shaped micro-channel of the double-T-shaped micro-fluidic device along the same direction respectively; wherein, the double T-shaped micro-channel is provided with two T-shaped intersections;
2) mixing the W1 phase and the O phase at the first T-shaped intersection to obtain a first emulsion with the W1 phase wrapped by the O phase;
3) the first emulsion is mixed with W2 at the second T-shaped intersection, so that O phase fluid wrapping the W1 phase can form double emulsion in the W2 phase, and the whitening, moisturizing and bacteriostatic external composition is obtained.
Further, the wall surface of the channel at the first T-shaped intersection is a hydrophobic wall surface, so that the W1 phase can form monodisperse droplets in the O phase; the channel wall at the second T-intersection is a hydrophilic wall, allowing the O-phase fluid encapsulating the W1 phase to form a double emulsion in the W2 phase.
The third purpose of the invention is realized by adopting the following technical scheme:
the whitening, moisturizing and bacteriostatic external composition is applied, and the whitening, moisturizing and bacteriostatic external composition comprises but is not limited to cosmetics for preparing essence, emulsion, cream and facial mask.
Compared with the prior art, the invention has the beneficial effects that:
(1) the external composition of the invention is W1/O/W2 type double emulsion; wherein, the W2 phase is an external water phase, the O phase is an intermediate oil phase, and the W1 phase is an internal water phase; the phase W1 comprises a secondary split yeast extract and/or a lactobacillus fermentation product filtrate; the O phase comprises essential oil, oil and fat and lipophilic emulsifier; the W2 phase comprises a skin conditioning agent, a hydrophilic surfactant, a thickening agent and water; the outermost layer is hydrophilic components which can obtain fresh skin feel, the middle oil layer (O phase) can play a role in slow release and activity protection on the secondary split yeast extract and lactobacillus fermentation product filtrate, the external composition disclosed by the invention enables probiotic products such as the secondary split yeast extract and lactobacillus fermentation product filtrate to be combined with essential oil and grease, the probiotic products and other active substances are protected from being oxidized, the skin feel can be effectively adjusted, and the greasy feel is avoided.
(2) The composition has the beneficial effects that the phase W1 is the split yeast extract and/or the lactobacillus fermentation product filtrate, the split yeast extract has the effects of ultraviolet damage resistance, repair, oxidation resistance and wrinkle resistance, the lactobacillus fermentation product filtrate is used as a metabolite of lactobacillus and has the effects of whitening, moisturizing and oxidation resistance, and the phase W1 is wrapped in the innermost layer, so that the moisturizing effect is lasting; the W2-phase skin conditioner is prepared from kapok extract, schizophyllan, rice fermentation product filtrate and/or distiller's grains extract, and has antioxidant, antibacterial and moisturizing effects; and the plant essential oil contained in the O phase has spectral antimicrobial activity and can inhibit and kill bacteria, fungi and viruses, so that the addition amount of a preservative in a system can be reduced, and the essential oil and the grease are compounded, so that the addition amount of the grease is reduced, and the using feeling of the whole composition is lighter and thinner.
(3) The external composition is prepared by a double-T type micro-fluidic device, and W1 phase, O phase and W2 phase fluids are respectively injected into a T type micro-channel of the double-T type micro-fluidic device along the same direction; wherein, the double T-shaped micro-channel is provided with two T-shaped intersections. The channel wall at the first T-intersection is a hydrophobic wall so that the W1 phase can form monodisperse droplets in the O phase; the second T-intersection was treated as a hydrophilic wall to allow the O-phase fluid encapsulating the W1 phase to form a double emulsion in the W2 phase. In the T-shaped channel of the device, the dispersed phase is broken into droplets at the node or the downstream of the node under the combined action of surface tension, shearing force of the continuous phase, viscous force at the tip of the node and the like, and the droplets are uniformly distributed in the continuous phase, so that the double-emulsion droplets produced by the method have good uniformity and high wrapping rate.
Drawings
FIG. 1 is a structural view of W1/O/W2 of the composition of the present invention;
fig. 2 is a schematic structural diagram of a double T-shaped microfluidic device.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and the detailed description, and it should be noted that any combination of the embodiments or technical features described below can be used to form a new embodiment without conflict.
Example 1
A whitening, moisturizing and bacteriostatic external composition is W1/O/W2 type double emulsion as shown in figure 1; wherein, the W2 phase is an external water phase, the O phase is an intermediate oil phase, and the W1 phase is an internal water phase; the composite material comprises the following raw materials in percentage by weight:
w1 phase is composed of 3 wt% of yeast extract and 4 wt% of lactobacillus fermentation product filtrate;
the O phase comprises 0.3 wt% of essential oil, 25 wt% of grease and 8 wt% of lipophilic emulsifier;
the W2 phase comprises 6 wt% of kapok extract, 8 wt% of schizophyllan, 6 wt% of rice fermentation product filtrate, 7 wt% of hydrophilic surfactant, 1 wt% of thickener and water; make up to 100 wt% from the water in the W2 phase. Wherein the grease is prepared from the following components in percentage by mass: 1: 2, rose hip oil, camellia oil, and squalane; the essential oil is rose essential oil; the mass ratio of the lipophilic emulsifier to the lipophilic emulsifier is 1: 1 lecithin and soybean lecithin; the hydrophilic surfactant is polyoxyethylene monolaurate.
The preparation method of the whitening, moisturizing and bacteriostatic external composition comprises the following steps:
1) injecting W1 phase, O phase and W2 phase fluid into the T-shaped micro-channel of the double-T-shaped micro-fluidic device shown in the figure 2 along the same direction respectively; wherein, the double T-shaped micro-channel is provided with two T-shaped intersections;
2) mixing the W1 phase and the O phase at the first T-shaped intersection, wherein the wall surface of the channel at the first T-shaped intersection is a hydrophobic wall surface, so that the W1 phase can form monodisperse droplets in the O phase, and a first emulsion with the W1 phase wrapped by the O phase is obtained;
3) the first emulsion is mixed with W2 at the second T-shaped intersection, and the channel wall surface at the second T-shaped intersection is a hydrophilic wall surface, so that O phase fluid wrapping the W1 phase can form double emulsion in the W2 phase, and the whitening, moisturizing and bacteriostatic external composition is obtained.
Example 2
A whitening, moisturizing and bacteriostatic external composition is W1/O/W2 type double emulsion as shown in figure 1; wherein, the W2 phase is an external water phase, the O phase is an intermediate oil phase, and the W1 phase is an internal water phase; the composite material comprises the following raw materials in percentage by weight:
w1 phase is composed of 1 wt% of yeast extract and 1 wt% of lactobacillus fermentation product filtrate;
the O phase is 0.1 wt% of essential oil, 20 wt% of grease and 5 wt% of lipophilic emulsifier;
the W2 phase comprises 5 wt% of kapok extract, 5 wt% of schizophyllan, 5 wt% of distiller's grains extract, 5 wt% of hydrophilic surfactant, 1 wt% of thickening agent and water; make up to 100 wt% from the water in the W2 phase. Wherein the grease is prepared from the following components in percentage by mass: 1, vitamin E and squalane; the essential oil is prepared from the following components in percentage by mass of 1: 1: 1 tea tree essential oil, frankincense essential oil and rose essential oil; the lipophilic emulsifier is polyoxyethylene stearate; the hydrophilic surfactant is tween 80.
The preparation method of the composition for external use of this example was the same as that of example 1.
Example 3
A whitening, moisturizing and bacteriostatic external composition is W1/O/W2 type double emulsion as shown in figure 1; wherein, the W2 phase is an external water phase, the O phase is a middle oil phase, and the W1 phase is an internal water phase; the composite material comprises the following raw materials in percentage by weight:
the W1 phase is 5 wt% of the yeast extract and 5 wt% of the lactobacillus fermentation product filtrate;
the O phase is 0.5 wt% of essential oil, 30 wt% of grease and 10 wt% of lipophilic emulsifier;
the W2 phase is 10 wt% of kapok extract, 10 wt% of schizophyllan, 5 wt% of rice fermentation product filtrate, 5 wt% of distiller's grains extract, 10 wt% of hydrophilic surfactant, 2 wt% of thickening agent and water; make up to 100 wt% from the water in the W2 phase. Wherein the oil is jojoba oil and Prinsepia utilis Royle oil; the essential oil is lavender essential oil; the lipophilic emulsifier is polyethylene glycol dioleate; the hydrophilic surfactant is polyvinyl alcohol.
The preparation method of the composition for external use of this example was the same as in example 1.
Example 4
A whitening, moisturizing and bacteriostatic external composition is W1/O/W2 type double emulsion as shown in figure 1; wherein, the W2 phase is an external water phase, the O phase is a middle oil phase, and the W1 phase is an internal water phase; the composite material comprises the following raw materials in percentage by weight:
the W1 phase is 3 wt% of a schizosaccharomyces cerevisiae extract;
the O phase comprises 0.4 wt% of essential oil, 25 wt% of grease and 7 wt% of lipophilic emulsifier;
the W2 phase comprises 7 wt% of kapok extract, 6 wt% of schizophyllan, 8 wt% of rice fermentation product filtrate, 6 wt% of hydrophilic surfactant, 1.5 wt% of thickening agent and water; make up to 100 wt% from the water in the W2 phase. Wherein the grease is prepared from the following components in percentage by mass: 1 pumpkin seed oil and safflower oil; the essential oil is prepared from the following components in percentage by mass of 1: 1: 1 tea tree essential oil, lavender essential oil and verbena essential oil; the lipophilic emulsifier is polyethylene glycol dioleate; the hydrophilic surfactant is polyvinyl alcohol.
The preparation method of the composition for external use of this example was the same as that of example 1.
Example 5
A whitening, moisturizing and bacteriostatic external composition is W1/O/W2 type double emulsion as shown in figure 1; wherein, the W2 phase is an external water phase, the O phase is an intermediate oil phase, and the W1 phase is an internal water phase; the composite material comprises the following raw materials in percentage by weight:
the W1 phase is 1-5 wt% of lactobacillus fermentation product filtrate;
the O phase comprises 0.2 wt% of essential oil, 22 wt% of grease and 9 wt% of lipophilic emulsifier;
the W2 phase comprises 7 wt% of kapok extract, 7 wt% of schizophyllan, 6 wt% of distiller's grains extract, 6 wt% of hydrophilic surfactant, 1 wt% of thickening agent and water; make up to 100 wt% from the water in the W2 phase. Wherein the oil is vitamin E acetate; the essential oil is prepared from the following components in percentage by mass of 1: 1: 1 geranium essential oil, myrrh essential oil and frankincense essential oil; the mass ratio of the lipophilic emulsifier to the lipophilic emulsifier is 1: 1 gum arabic and lecithin; the hydrophilic surfactant is polyoxyethylene lauryl ether.
The preparation method of the composition for external use of this example was the same as in example 1.
Comparative example 1
Comparative example 1 compared to example 1, the product formulation was the same but the specific preparation method was different.
The composition of comparative example 1 was also a double emulsion of type W1/O/W2, prepared by a process comprising the steps of:
1) completely dissolving the components in the W2 water phase, slowly adding into the O phase in a stirring state, and homogenizing and emulsifying to obtain a water-in-oil emulsion;
2) the water-in-oil emulsion was slowly added to the W2 phase in a stirred state, and then subjected to emulsification to obtain a double emulsion.
Comparative example 2
Comparative example 2 compared to example 1, the product formulation was the same except that: the W1 phase and the W2 phase of comparative example 2 were integrated and added simultaneously to prepare a W/O oil-in-water emulsion by a conventional mixing emulsification method.
Comparative example 3
Comparative example 3 compared to example 1, comparative example 3 was prepared without adding kapok extract, and the amounts of the remaining components added and the preparation method were the same as in example 1.
Comparative example 4
Comparative example 4 compared to example 1, comparative example 4 was prepared without addition of Schizophyllum commune polysaccharide, and the amounts of the remaining components added and the preparation method were the same as in example 1.
Comparative example 5
Comparative example 5 compared with example 1, comparative example 5 was prepared without adding rice fermented product filtrate, and the amounts of the remaining components added and the preparation method were the same as in example 1.
Performance test and Effect evaluation
One, high and low temperature storage stability test
The products of examples 1-5 and comparative examples 1-2 were stored at-5 ℃ for 24h, then at room temperature for 24h, and then placed in a thermostat at 40 ℃ for 24h, and the cycle was repeated 3 times in sequence, and the stability was observed, as shown in table 1.
TABLE 1 test results of high-temperature and Low-temperature storage stability of each group
As can be seen from table 1, the composition of the present invention prepared a double emulsion by a microfluidic process, and the stability of the emulsified system was better than that of the conventional mixing and stirring package.
Second, moisture retention test
The test method comprises the following steps: 5.0g each of the compositions of examples 1, 3 and 5 and comparative examples 3 to 5 was weighed, placed in weighing bottles, and left in an environment having a relative humidity of 43% and 81% at room temperature (24 to 30 ℃) for 24 hours, and the moisture retention rate was calculated according to formula (1).
In the formula, m0G, the mass of a sample to be detected; m isnMass of sample, g, after 24 hours of standing.
The moisturizing rate data for each group is shown in table 2.
TABLE 2 moisture retention data for each group
As is clear from Table 1, the moisture retention rate was the highest in example 1, and was decreased in examples 4 and 5 without adding the Schizosaccharomyces pombe extract and the lactic acid bacterium fermentation product filtrate, respectively. In comparative examples 3-5, the kapok extract, the schizophyllan and the rice fermentation product filtrate are not added, so that the moisture retention rate is greatly reduced, and the influence of the kapok extract, the schizophyllan and the rice fermentation product filtrate on the moisture retention rate is large. The kapok extract, the schizophyllan and the rice fermentation product filtrate can play the optimal moisturizing effect.
Third, test of whitening Performance
The preparation method of the solution to be detected comprises the following steps: weighing 1.0g of each sample, uniformly dispersing the samples by using distilled water, transferring the samples into a 100mL volumetric flask for constant volume, and respectively diluting the samples to be detected until the concentration of the samples is 5.0 mg/mL.
The method for measuring the tyrosinase inhibition rate comprises the following steps: respectively preparing a Phosphate Buffer Solution (PBS) with the pH value of 6.83, a tyrosinase solution with the mass concentration of 0.07mg/mL and an L-tyrosinase solution with the mass concentration of 1.0 mg/mL. Accurately preparing a solution to be detected 1: 2.0mL of PBS +0.5mL of tyrosinase solution +0.5mL of L-tyrosinase solution; and (3) liquid to be detected 2: 2.5mL PBS +0.5mL tyrosinase solution; solution to be tested 3: 0.5mL of a solution to be tested, 1.5mL of PBS, 0.5mL of tyrosinase solution and 0.5mL of tyrosine solution; and (4) a to-be-detected liquid: 0.5mL of the solution to be tested +2.0mL of LPBS +0.5mL of the tyrosinase solution. Preserving the temperature in a 37 ℃ water bath for 30min, immediately measuring the absorbance at 475nm, and respectively recording the absorbance as A1、A2、A3、A4. Tyrosinase inhibition was calculated according to formula (2). The data are shown in table 3.
I＝[(A1-A2)-(A3-A4)]/(A1-A2)×100％ (2)
Fourth, testing the oxidation resistance
The preparation method of the solution to be detected comprises the following steps: weighing 1.0g of each sample, uniformly dispersing the samples by using distilled water, transferring the samples into a 100mL volumetric flask for constant volume, and respectively diluting the samples to be detected until the concentration of the samples is 5.0 mg/mL.
Method for measuring DPPH-radical inhibition ratio: adding 3mL of the solution to be detected and 3mL of 0.2mmol/L DPPH-ethanol solution into the same test tube with a plug, shaking, standing in the dark at room temperature for 30min, and measuring the absorbance A at the wavelength of 517nmi1The absorbance A of the mixture of the extractant and 3mL each of the DPPH and ethanol solutions was measured by the same method01And absorbance A of the mixture of the solution to be detected and 3mL of absolute ethyl alcoholj1The inhibition ratio P is calculated according to the formula (3). The data are shown in table 3.
P＝[1-(Ai1-Aj1)/A01]×100％。
TABLE 3 inhibition of tyrosinase and free radical by the compositions of each group
| Group of | I/％ | P/％ |
| Example 1 | 72.7 | 95.3 |
| Example 4 | 66.5 | 90.1 |
| Example 5 | 68.2 | 91.8 |
| Comparative example 3 | 50.7 | 76.4 |
| Comparative example 4 | 53.0 | 78.2 |
| Comparative example 5 | 55.8 | 79.2 |
As is clear from Table 3, example 1 showed the highest inhibitory activity against tyrosinase and DPPH.radical, indicating that both whitening and antioxidant effects were the best. According to the whitening effect (the influence degree is from large to small), parameters influencing the whitening effect can be sequentially arranged as follows: kapok extract, schizophyllan and rice fermentation product filtrate. According to the antioxidant effect (the influence degree is from large to small), the parameters influencing the effect can be sequentially arranged as follows: kapok extract, schizophyllan and rice fermentation product filtrate. Therefore, the combination of the common bombax flower extract, the schizophyllum commune polysaccharide and the rice fermentation product filtrate can achieve the optimal whitening and antioxidant effects.
Fifth, bacteriostasis test
The products of example 1 and comparative examples 3-5 were tested for bacteriostatic effect by the filter paper sheet method, as shown in table 4.
TABLE 4 bacteriostatic effect of the respective groups of products
As can be seen from Table 4, the essential oil is added in the examples 1 and the comparative examples 3-5, so that the antibacterial effect is certain, but the kapok extract is not added in the comparative example 3, so that the antibacterial effect is greatly reduced, and therefore, the kapok extract has an inhibiting effect on Propionibacterium acnes and Staphylococcus epidermidis. The bacteriostatic effect of the filtrate of the schizophyllum commune polysaccharide and the rice fermentation product is not greatly influenced.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (10)
1. The external composition for whitening, moisturizing and bacteriostasis is characterized by being W1/O/W2 type double emulsion; wherein, the W2 phase is an external water phase, the O phase is a middle oil phase, and the W1 phase is an internal water phase; the W1 phase comprises a yeast extract and/or lactobacillus fermentation product filtrate; the O phase comprises essential oil, oil and fat and lipophilic emulsifier; the W2 phase comprises skin conditioning agent, hydrophilic surfactant, thickening agent and water.
2. The whitening, moisturizing and bacteriostatic external composition according to claim 1, wherein the skin conditioner is one or more of kapok extract, schizophyllan, rice fermentation product filtrate and distiller's grains extract.
3. The whitening, moisturizing and bacteriostatic composition for external use according to claim 1, wherein the oil is one or more of squalene, squalane, jojoba oil, prinsepia utilis royle oil, wheat germ oil, sunflower seed oil, cottonseed oil, corn oil, olive oil, tea tree oil, palm oil, soybean oil, rose hip oil, evening primrose oil, cod liver oil, pumpkin seed oil, safflower oil, camellia oil, clove stem and leaf oil, clove oil, eugenol, vitamin E succinate, vitamin E acetate and light liquid paraffin.
4. The whitening, moisturizing and bacteriostatic external composition according to claim 1, wherein the essential oil is one or more of rosemary essential oil, geranium essential oil, tea tree essential oil, frankincense essential oil, rose essential oil, lavender essential oil, chamomile essential oil, citronella essential oil and verbena essential oil.
5. The whitening, moisturizing and bacteriostatic external composition according to claim 1, wherein the lipophilic emulsifier is one or more of acacia, lecithin, soybean lecithin, sorbitan sesquioleate, sorbitan monostearate, polyethylene glycol dioleate, polyoxyethylene stearate, polyoxyethylene fatty alcohol ether, and polyoxyethylene (30) dipolyhydroxystearate.
6. The topical composition for whitening, moisturizing and bacteriostasis of claim 1, wherein the hydrophilic surfactant is one or more of polyoxyethylene monolaurate, polyoxyethylene lauryl ether, polyoxyethylene monopalmitate, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, tween 60, tween 65, tween 80, tween 85, poloxamer, polyvinyl alcohol, sodium lauryl sulfate, caprylic/capric polyethylene glycol glyceride, polyethylene glycol-15 hydroxystearate, polyethylene glycol 300, polyethylene glycol 400, ethanol, propylene glycol and stearyl alcohol.
7. The external composition for whitening, moisturizing and bacteriostasis according to claim 1, which comprises the following raw materials in percentage by weight:
the W1 phase is 1-5 wt% of the secondary split yeast extract and 1-5 wt% of the lactobacillus fermentation product filtrate;
the O phase comprises 0.1-0.5 wt% of essential oil, 20-30 wt% of grease and 5-10 wt% of lipophilic emulsifier;
the W2 phase comprises 15-30 wt% of a skin conditioner, 5-10 wt% of a hydrophilic surfactant, 1-2 wt% of a thickening agent and water; make up to 100 wt% from the water in the W2 phase.
8. The preparation method of the whitening, moisturizing and bacteriostatic external composition according to claims 1 to 7, which is characterized by comprising the following steps:
1) injecting W1 phase fluid, O phase fluid and W2 phase fluid into a T-shaped micro-channel of the double-T-shaped micro-fluidic device along the same direction respectively; wherein, the double T-shaped micro-channel is provided with two T-shaped intersections;
2) mixing the W1 phase and O phase at the first T-shaped intersection to obtain a first emulsion with the W1 phase wrapped by the O phase;
3) the first emulsion is mixed with W2 at the second T-shaped intersection, so that O phase fluid wrapping the W1 phase can form double emulsion in the W2 phase, and the whitening, moisturizing and bacteriostatic external composition is obtained.
9. The method for preparing a whitening, moisturizing and bacteriostatic external composition according to claim 8, wherein the wall surface of the channel at the first T-shaped intersection is a hydrophobic wall surface; the channel walls at the second T-intersection are hydrophilic walls.
10. The application of the whitening, moisturizing and bacteriostatic external composition according to claims 1 to 8, wherein the whitening, moisturizing and bacteriostatic external composition is used for preparing cosmetics such as essence, emulsion, cream and mask.
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