CN114728011A - 包含类固醇二聚体的制品及其在治疗剂递送中的用途 - Google Patents

包含类固醇二聚体的制品及其在治疗剂递送中的用途 Download PDF

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Publication number
CN114728011A
CN114728011A CN202080067487.9A CN202080067487A CN114728011A CN 114728011 A CN114728011 A CN 114728011A CN 202080067487 A CN202080067487 A CN 202080067487A CN 114728011 A CN114728011 A CN 114728011A
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CN
China
Prior art keywords
article
straight
branched
chain
steroid
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Pending
Application number
CN202080067487.9A
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English (en)
Chinese (zh)
Inventor
伊恩·查尔斯·帕拉格
马修·亚历山大·约翰·斯坦森
J·保罗·桑特雷
温迪·艾莉森·奈马克
亚当·布鲁斯·戴利
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Ripple Therapeutics Corp
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Ripple Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ripple Therapeutics Corp filed Critical Ripple Therapeutics Corp
Publication of CN114728011A publication Critical patent/CN114728011A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080067487.9A 2019-07-25 2020-07-24 包含类固醇二聚体的制品及其在治疗剂递送中的用途 Pending CN114728011A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962878477P 2019-07-25 2019-07-25
US62/878,477 2019-07-25
PCT/IB2020/000620 WO2021014217A1 (en) 2019-07-25 2020-07-24 Articles comprising steroid dimers and their use in the delivery of therapeutic agents

Publications (1)

Publication Number Publication Date
CN114728011A true CN114728011A (zh) 2022-07-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080067487.9A Pending CN114728011A (zh) 2019-07-25 2020-07-24 包含类固醇二聚体的制品及其在治疗剂递送中的用途

Country Status (5)

Country Link
US (1) US20220289787A1 (https=)
EP (1) EP4003362A4 (https=)
JP (1) JP2022541341A (https=)
CN (1) CN114728011A (https=)
WO (1) WO2021014217A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111971292B (zh) 2018-02-02 2024-12-13 波纹疗法公司 包含类固醇二聚体的玻璃制剂及其用途
WO2020154815A1 (en) 2019-02-01 2020-08-06 Ripple Therapeutics Corporation Crystalline forms of dexamethasone dimers and uses thereof
US12509469B2 (en) 2019-08-07 2025-12-30 Ripple Therapeutics Corporation Compositions and methods for the treatment of pain and dependence disorders
WO2021220061A2 (en) 2020-05-01 2021-11-04 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders
WO2024013565A1 (en) * 2022-07-12 2024-01-18 Ripple Therapeutics Corporation Compositions and methods for improving vision
WO2025049690A1 (en) * 2023-08-29 2025-03-06 Orna Therapeutics, Inc. Circular polyethylene glycol lipids

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1046098A (zh) * 1989-03-09 1990-10-17 恩度康有限公司 部分熔合多肽小丸剂
WO1995020567A1 (en) * 1994-01-28 1995-08-03 University Of Kentucky Research Foundation Codrugs as a method of controlled drug delivery
US20030158598A1 (en) * 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
US20090124591A1 (en) * 2001-08-16 2009-05-14 The Trustees Of The University Of Pennsylvania Synthesis and Use of Cationic Steroids for Anti-Inflammatory Drug Therapy
CN105377319A (zh) * 2013-03-15 2016-03-02 界面生物公司 用于药物释放的化合物和组合物
CN108350022A (zh) * 2015-11-12 2018-07-31 内布拉斯加大学董事会 聚乙二醇缀合的糖皮质激素前体药物及其组合物和方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE106238T1 (de) * 1989-03-09 1994-06-15 Endocon Inc Teilweise geschmolzenes peptidpellet.
CN111971292B (zh) * 2018-02-02 2024-12-13 波纹疗法公司 包含类固醇二聚体的玻璃制剂及其用途

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1046098A (zh) * 1989-03-09 1990-10-17 恩度康有限公司 部分熔合多肽小丸剂
WO1995020567A1 (en) * 1994-01-28 1995-08-03 University Of Kentucky Research Foundation Codrugs as a method of controlled drug delivery
US20090124591A1 (en) * 2001-08-16 2009-05-14 The Trustees Of The University Of Pennsylvania Synthesis and Use of Cationic Steroids for Anti-Inflammatory Drug Therapy
US20030158598A1 (en) * 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
CN105377319A (zh) * 2013-03-15 2016-03-02 界面生物公司 用于药物释放的化合物和组合物
CN108350022A (zh) * 2015-11-12 2018-07-31 内布拉斯加大学董事会 聚乙二醇缀合的糖皮质激素前体药物及其组合物和方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VACLAV JANOUT ET AL: "Bioconjugate-Based Molecular Umbrellas", 《BIOCONJUGATE CHEMISTRY》, vol. 20, no. 2, pages 183 - 192, XP055787423, DOI: 10.1021/bc800296g *

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US20220289787A1 (en) 2022-09-15
EP4003362A4 (en) 2023-11-15
WO2021014217A1 (en) 2021-01-28
JP2022541341A (ja) 2022-09-22
EP4003362A1 (en) 2022-06-01

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